Entries |
Document | Title | Date |
20080228253 | Surface modifying macromolecules with high degradation temperatures and uses thereof - The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties. | 09-18-2008 |
20090319016 | PROCESS FOR PRODUCTION OF POROUS BODY AND USES THEREOF - A process for producing a porous body with different physical properties in desired regions is provided by pore forming treatment, not by bonding two or more materials made porous beforehand, with, for example, an adhesive. Raw materials are prepared, each of which contains a polymer and a raw material preparation solvent. At least two types of the raw materials having different compositions are prepared. Thereafter, the respective raw materials are frozen into desired shapes to form frozen bodies thereof. The frozen bodies thus formed are brought into contact with each other to form an assembly thereof, the assembly is exposed to a condition under which the frozen bodies begin to melt, and the assembly is then freeze-dried. Thus, a porous body having regions different in physical properties can be obtained. Such a porous body can be used as, for example, an adhesion inhibitory material or a scaffold for a cell culture. | 12-24-2009 |
20100030313 | MEDICAL ARTICLES COMPRISING BIODEGRADABLE BLOCK COPOLYMERS - The present invention is directed to medial articles having bioerodible polymeric regions that contain biodegradable block copolymers. The biodegradable block copolymers include at least one first biodegradable polymer block and least one second biodegradable polymer block that differs from the first biodegradable polymer block. The bioerodible polymeric regions comprise a first phase domain formed from the at least one first biodegradable polymer block and a second phase domain formed from the at least one second biodegradable polymer block. At least one of the first and second phase domains is a discontinuous phase domain in the form of dispersed phase elements, substantially all of which have a longest cross-sectional dimension that is less than 1 micron. | 02-04-2010 |
20100042197 | PREPARATION OF HOLLOW CELLULOSE VESSELS - The present invention relates to an improved method for the preparation of hollow cellulose vessels produced by a microorganism, and hollow cellulose vessels prepared by this method. The method is characterized by the culturing of the cellulose-producing microorganisms being performed on the outer surface of a hollow carrier, and providing an oxygen containing gas on the inner side of the hollow carrier, the oxygen containing gas having an oxygen level higher than atmospheric oxygen. The hollow microbial cellulose vessels of the present invention are characterized by improved mechanical properties and can be used in surgical procedures to replace or repair an internal hollow organ such as the urethra, ureter, the trachea, a digestive tract, a lymphatic vessel or a blood vessel | 02-18-2010 |
20100106233 | BIONANOCOMPOSITE FOR TISSUE REGENERATION AND SOFT TISSUE REPAIR - The present invention provides a bionanocomposite including a pre-selected decellularized tissue crosslinked with a pre-selected nanomaterial. Also provided is a process for fabricating the bionanocomposite. Additionally, applications for using the bionanocomposite as soft tissue repair materials or scaffolds for tissue engineering are described. | 04-29-2010 |
20100168832 | SCAFFOLDS FOR ARTIFICIAL HEART VALVES AND VASCULAR STRUCTURES - The invention relates to scaffolds for artificial heart valves and vascular structures comprising a biocompatible block copolymer. A method and means for producing said scaffold are also provided. | 07-01-2010 |
20100174351 | CHEMICALLY AND BIOLOGICALLY MODIFIED MEDICAL DEVICES - Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate. | 07-08-2010 |
20100262215 | Method and Device to Treat and Prevent Dialysis Graft Failure - A treatment assembly is positioned along an AV-fistula and couples therapeutic energy to an adjacent area due to a material response to an applied energy field from a remotely located energy source. The treatment assembly may be delivered into the fistula through a hemodialysis needle, or may be secured to the fistula graft itself and implanted therewith in a patient. A cover provides a shield between an anastomosis area and blood flow. Another AV-fistula includes a valved reservoir that receives a fluid agent from a hemodialysis needle while moving the needle into or from the fistula; the agent leaks from the reservoir into the fistula lumen. Another valved fistula is adjustable between an open condition and closed conditions during and between hemodialysis treatments, respectively. Another AV-fistula has a bladder reservoir coupled to a second refillable fluid reservoir and is adapted to locally deliver a therapeutic agent into the fistula lumen. | 10-14-2010 |
20100292770 | ENDOVASCULAR GRAFT JOINT AND METHOD FOR MANUFACTURE - A joint and method for producing a joint in an endovascular graft. In one embodiment, a flap of a flexible material portion of an endovascular graft is folded about a portion of an expandable member to form a loop portion. The flap is secured in the loop configuration so that tensile force on the expandable member is transferred into a shear force on the fixed portion of the flap. | 11-18-2010 |
20110022148 | THERMO-MECHANICALLY CONTROLLED IMPLANTS AND METHODS OF USE - An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated temperatures above normal body temperature. The implant also has a plurality of particles dispersed in the structure that are adapted to convert incident radiation into heat energy when irradiated with electromagnetic radiation. The particles are in thermal contact with the structure such that exposure of the particles to incident radiation raises the temperature of the structure thereby changing the first material property relative to the first material property at normal body temperature. | 01-27-2011 |
20110077729 | DEVICES AND METHODS FOR CONTROL OF BLOOD PRESSURE - Apparatus and methods are described, including identifying a subject as suffering from hypertension. In response to the identifying (a) a radius of curvature of a first set of at least three regions of an arterial wall of the subject is increased at a given longitudinal location, while (b) allowing the first set of regions of the arterial wall to pulsate. A device is implanted inside the artery at the longitudinal location such that the device applies pressure to the arterial wall at a second set of at least three regions of the artery, but does not contact the first set of regions, the first set of regions and the second set of regions alternating with each other. Other embodiments are also described. | 03-31-2011 |
20110112620 | Single continuous piece prosthetic tubular aortic conduit and method for manufacturing the same - A prosthetic aortic conduit for replacing a root portion of an aorta is provided. The conduit comprises a continuous tubular conduit along a substantially common axis. A portion of the tubular conduit does not substantially deform in a longitudinal direction and has resilient means which allow said another portion of the conduit to be expandable in a lateral direction. The portion that is able to deform laterally mimics the function of the sinuses of Valsalva. The method of manufacturing such a conduit comprises the steps of having a continuous weave of rows of yarn or the equivalent with a change in tightness of the rows so that in some portion of the conduit it is expandable in the lateral direction and in some portion of the conduit it is expandable in the longitudinal direction. | 05-12-2011 |
20110112621 | PERCUTANEOUSLY DEPLOYED VASCULAR VALVES - Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel. | 05-12-2011 |
20110152992 | DEVICE AND METHOD FOR TACKING PLAQUE TO BLOOD VESSEL WALL USING WIRE MESH ANNULAR BAND - A plaque tack device for treating atherosclerotic occlusive disease is formed as a thin, annular band made of thin, flexible wire formed in a mesh structure having a plurality of barbs on its outer periphery. It has a width that is small relative to its diameter, to minimize the amount of foreign structure placed in the blood vessel. One or more tacks may be applied in positions along a plaque accumulation site as needed to stabilize the site and/or hold pieces of plaque out of the way of blood flow. The barbs of the tack may be pressed into the plaque and/or blood vessel walls by balloon expansion. Related methods of deployment and delivery devices are provided for insertion of the plaque tack in a compressed state into the blood vessel and expanding it back to its annular shape for holding plaque against the blood vessel walls. | 06-23-2011 |
20110196467 | BLOOD VESSEL WRAP | 08-11-2011 |
20110196468 | INTRAVASCULAR DEVICES FOR TREATING BLOOD VESSELS AND A METHOD OF USING SUCH DEVICES - A medical implant for occluding a blood vessel. The medical implant comprises a cup shaped elastic blood impermeable membrane sized and shaped for substantially occluding a lumen of a blood vessel, at least one scaffolding element mounted, sized and shaped for being attached at least one blood clot forming in front of the elastic blood impermeable membrane, and at least one anchoring element having a tip directed outward from the center of the cup shaped elastic blood impermeable membrane. | 08-11-2011 |
20110218606 | Methods for Stabilizing Femoral Vessels - The invention provides methods for stabilizing the femoral artery. | 09-08-2011 |
20110264184 | SLEEVE AND TUBING DEVICE FOR RESTRICTING AND CONSTRICTING ANEURYSMS AND A SYSTEM AND METHOD FOR USING SUCH A DEVICE - A sleeve device, system and method are provided for restricting and/or constricting aneurysms. More particularly, a sleeve and/or a double-walled sleeve is located in or on a vessel in the location of an aneurysm. When placed around the outside of a vessel, is used to constrict the aneurysm containing portion of the vessel. Optionally, a saddle portion can be disposed outside of the vessel to hold the sleeve in a desired location. When placed inside the vessel, the sleeve is provided to bypass blood flowing through the aneurysm. If desired, the sleeve may be constructed as a double-walled sleeve that can be inflated to apply pressure to and/or in the vessel. | 10-27-2011 |
20120046725 | Method for Providing an Aid for Use in the Therapeutic Treatment of a Somatic Subject - Blood flow turbulence or stationary blood can occur in vessels of the body, in particular following surgical interventions or minimally invasive interventional procedures, and this can lead to the formation of thrombi. A model of such vessels is obtained on the basis of a 3D image dataset, a simulation is then performed and a check carried out to determine whether turbulence or stationary blood can be demonstrated in the simulation. The model is then modified, successively where necessary, until the simulation reveals no more turbulence. Then, on the basis of the most recently modified model that results in no turbulence and no stationary blood, an aid is provided, in particular a specific aid such as e.g. a stent produced or a screen display presented. | 02-23-2012 |
20120303108 | EMBOLIZATION DEVICE AND A METHOD OF USING THE SAME - Non-expandable space-occupying devices for treating voids within the body are disclosed. The devices can have multiple non-expandable space-occupying elements connected to a flexible leader. Methods of making and using the devices are also disclosed. | 11-29-2012 |
20130006342 | EXPRESSION SIGNATURE IN PERIPHERAL BLOOD FOR DETECTION OF AORTIC ANEURYSM - We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA. | 01-03-2013 |
20130053938 | SURFACE PROTECTIVE AND RELEASE MATRICES - A molecular plasma deposition (MPD) method in combination with an atomic layer deposition (ALD) procedure is used to produce amorphous, nonconformal thin metal film coatings on a variety of substrates. The films are porous, mesh-like lattices with imperfections such as pinholes and pores, which are useful as scaffolds for cell attachment, controlled release of bioactive agents and protective coatings. | 02-28-2013 |
20130053939 | METHOD FOR MANUFACTURING CYLINDRICAL NITINOL OBJECTS FROM SHEET - An article cut from a metallic sheet, has a first pattern of struts forming a plurality of inner apexes situated substantially within a plane that contains the plurality of the inner apexes. There is a second pattern of struts forming a plurality of outer apexes that are situated substantially within the plane containing the inner apexes. Each outer apex has at least one strut in common with an adjacent inner apex. There is also described a method of forming a non-planar three dimensional structure by patterning a planar sheet of material to form an article having a plurality of inner apexes, a plurality of outer apexes with a common curvilinear strut between an inner apex and an adjacent outer apex. Thereafter, everting the article into a non-planar three dimensional structure with the inner apexes at one end of the structure and the outer apexes at another end of the structure. | 02-28-2013 |
20130172974 | MODIFIED SURFACE FOR AN IMPLANTABLE DEVICE AND A METHOD OF PRODUCING THE SAME - Implantable devices, such as stents, having a surface modified with TiN | 07-04-2013 |
20130253629 | DEVICES AND METHODS FOR PERFUSING AN ORGAN - The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region. | 09-26-2013 |
20130310912 | COVALENT MODIFICATION OF METAL SURFACES - The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials. | 11-21-2013 |
20140058496 | DECELLULARIZED BIOLOGICALLY-ENGINEERED TUBULAR GRAFTS - This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts. | 02-27-2014 |
20140257450 | TUBE WITH MODIFIED INNER WALL SURFACE USING PLASMA AND A PREPARATION METHOD THEREOF - The present invention relates to a preparation method of a tube and a transplantable polymer tube prepared by such method, which includes modifying the inner surface of a tube using plasma. A preparation method of a tube may include preparing a tube, modifying the inner surface of the tube using microplasma so as to have reactivity, forming a thin film layer on the modified surface of the tube to prevent aging or impart adhesiveness, and modifying the surface of the thin film layer using microplasma so as to enhance cell adhesion thereon. | 09-11-2014 |
20140277328 | COMPOSITE MATERIAL AND USES THEREOF - A composite material for a medical implant includes a matrix of magnesium or magnesium alloy, and a catalyst which is dispersed within the matrix. The catalyst has the capacity to reduce an amount of hydrogen gas released from the matrix when the matrix is being degraded inside the patient. | 09-18-2014 |
20140379062 | IMPLANTABLE PROSTHETIC DEVICE FOR CONNECTION TO A FLUID FLOW PATHWAY OF A PATIENT AND METHODS OF USING THE SAME - An implantable prosthetic for connection to a fluid flow pathway of a patient. The prosthetic is comprised of a primary tube structure which is in communication with a plurality of secondary tube structures each of which contains filters for trapping embolic particles, such as blood clots, air bubbles, thrombus. etc. within a fluid flow pathway within a patient. The prosthetic also contains a monitoring device to non-invasively the flow of fluids through a patient's fluid flow pathway. | 12-25-2014 |
20150080998 | MAGNESIUM-ALUMINUM-ZINC ALLOY, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF - A magnesium alloy and to a method for the production thereof and implants made thereof. The magnesium alloy includes up to 6.0% by weight Zn, and preferably 2.0 to 4.0% by weight Zn, 2.0 to 10.0% by weight Al, and preferably 3.0 to 6.0% by weight Al, where % by weight Al≧% by weight Zn shall apply, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, and the matrix of the alloy is solid solution hardening due to Al and An and is also particle hardening due to the intermetallic phases formed of Mg and Al. | 03-19-2015 |
20150315681 | NOVEL NITINOL ALLOYS AND USES THEREOF IN SURGICAL IMPLANTS - The current invention provides novel nitinol alloys, particularly, nitinol alloys containing a third metallic element referred to as ternary nitinol alloys. Accordingly, the current invention provides nitinol alloys including, but not limited to, Nickel-Titanium-Chromium (NiTiCr) and Nickel-Titanium-Tantalum (NiTiTa). The current invention also provides implants manufactured from the ternary nitinol alloys. The implants comprise the ternary nitinol alloys and are, optionally, surface treated to promote anti-thrombogenicity and biocompatibility, for example, through magnetoelectropolishing (MEP). Accordingly, the current invention provides nitinol alloys and implants comprising the nitinol alloys that reduce the risk of clotting due to stagnant blood flow, eliminate flushing, and minimize infection and damage to blood vessels. | 11-05-2015 |
20160000978 | FUNCTIONAL FILM - A functional film that is applied to a surface of a medical apparatus or a biomaterial includes a film of Ti-doped tetrahedral amorphous carbon (ta-C:Ti film). | 01-07-2016 |
20160166327 | BEDSIDE INTERFACE FOR PERCUTANEOUS CORONARY INTERVENTION PLANNING | 06-16-2016 |