Class / Patent application number | Description | Number of patent applications / Date published |
623100380 | Absorbable in natural tissue | 71 |
20080249614 | Implantable medical devices fabricated from polymer blends with star-block copolymers - Implantable medical devices fabricated from polymer blends with star-block copolymers are disclosed. | 10-09-2008 |
20090082853 | BIODEGRADABLE DRUG DELIVERY MATERIAL FOR STENT - A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom. | 03-26-2009 |
20090088835 | IMPLANTABLE MEDICAL DEVICES FABRICATED FROM BLOCK COPOLYMERS - Medical devices, such as stents, fabricated at least in part from a polymer composite including a biodegradable elastomeric phase dispersed within a biodegradable polymeric matrix are disclosed. The composite is composed of a block copolymer including an elastomeric homopolymer block and a glassy polymer block. | 04-02-2009 |
20090138074 | DECELLULARIZED EXTRACELLULAR MATRIX OF CONDITIONED BODY TISSUES AND USES THEREOF - The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided. | 05-28-2009 |
20090171452 | Magnesium-Based Biodegradable Metallic Material - As a novel biodegradable metallic material the degradation speed of which in vivo can be controlled over a broad scope while achieving desired mechanical properties such as strength, work hardening and ductility without restricting the shape of an implant device, it is intended to provide a magnesium-based biodegradable metallic material which comprises Mg containing Mg as the major composition and having a concentration of inevitable impurities equal to or less than 0.05 atomic %, is free from precipitates or intermetallic compounds, and has an average grain size being regulated to equal to or less than ¼ of the minimum part of the material. | 07-02-2009 |
20090198320 | IMPLANT WITH A BASE BODY OF A BIOCORRODIBLE IRON ALLOY - An implant having a base body comprising entirely or in part a biocorrodible iron alloy wherein the base body of the implant comprises at least one of the following: (i) a biocorrodible iron alloy of formula (1): Fe—P where the amount of P in the alloy is from 0.01 to 5 wt %, and Fe plus impurities due to the production process account for the remainder of the alloy up to 100 wt %; or (ii) a biocorrodible iron alloy of the formula (2): Fe—Mn—X where the amount of Mn in the alloy is from 5 to 30 wt %, X stands for one or more elements selected from the group consisting of Pt, Pd, Ir, Rh, Re, Ru and Os, and the amount of X in the alloy is from 0 to 20 wt % and Fe plus impurities due to the production process account for the remainder of the alloy up to 100 wt %; or (iii) a biocorrodible iron alloy of formula (3): Fe-Z where Z is one or more elements selected from the group consisting of Pt, Ir and Os and the amount of Z in the alloy is from 5 to 30 wt %, and Fe plus impurities due to the production process account for the remainder of the alloy up to 100 wt %. | 08-06-2009 |
20090216316 | Bioabsorbable Stent With Layers Having Different Degradation Rates - A bioabsorbable stent including a stent scaffolding formed from polymer layers with different degradation rates is disclosed. The polymer layers include an abluminal layer, a luminal layer, and optionally one or more middle layers. A degradation rate of the layers increases from the luminal layer to the abluminal layer. | 08-27-2009 |
20090240323 | Controlled Degradation of Magnesium Stents - Implantable medical devices, more specifically stents, are described herein comprising magnesium based core structures whose elimination times are slowed by the appropriate polymer coating. Appropriate biodegradable polymers are selected which are suitable to provide a specific degradation time for the magnesium based core structure. Bioactive agents are incorporated into the polymer coating in order to aid in the therapeutic effect of the stent. | 09-24-2009 |
20090299464 | Reducing Bioabsorbtion Time of Polymer Coated Implantable Medical Devices Using Polymer Blends - Described herein is a system and method for reducing the risk of late thrombosis associated with drug eluting stent therapy. The stents described herein have polymeric blend coatings that can be tailored to have specific degradation times once implanted into the vasculature. The polymeric blends can have at least two polymers with different weight average molecular weights, thereby giving them degradation times that can tailored depending on the weight average molecular weights of the various polymers in the blend. The coatings can have bioactive agents dispersed on or within them which can be eluted in sync with the degradation time of the blended polymeric coating. | 12-03-2009 |
20090299465 | Absorbable / biodegradable tubular stent and methods of making the same - Medicated or unmedicated, absorbable/biodegradable, polymeric tubular stents for temporary placement in body lumens maintain patency and provide dimensional stability at the biological site. The stent design is based on a radially fluted, tubular form having grooves or flutes along its entire length for expansion to a predetermined diameter after deployment, using a balloon catheter, into a tubular body lumen through outward deformation of the fluted wall. | 12-03-2009 |
20090306770 | Tissue engineering of blood vessels - Method and apparatus for mapping the shape and dimensions of a 3-dimensional body, by applying to the 3-dimensional body a stretchable covering configured and dimensioned such that in its stretched condition it tightly engages and conforms to the shape and dimensions of the 3-dimensional body to be mapped. The stretchable covering carries a plurality of reference devices, such as bands and/or markers which are at known or determinable reference locations in an initial condition of the covering, and which change their locations in the stretched condition of the stretchable covering according to the shape and dimensions of the 3-dimensional body covered thereby. The locations of the markers on the stretchable covering are determined after the stretchable covering has been applied to the 3-dimensional body, and are utilized to produce a map of the shape and dimensions of the 3-dimensional body. | 12-10-2009 |
20090319031 | Bioabsorbable Polymeric Stent With Improved Structural And Molecular Weight Integrity - Various embodiments of the present invention include implantable medical devices such as stents manufactured from polymers, and more particularly, biodegradable polymers including biodegradable polyesters. Other embodiments include methods of fabricating implantable medical devices from polymers. The devices and methods utilize one or more stabilizers, where each stabilizer may be chosen from the following categories: free radical scavengers, peroxide decomposers, catalyst deactivators, water scavengers, and metal scavengers. | 12-24-2009 |
20100042205 | MEDICAL DEVICES HAVING ELECTRODEPOSITED CONDUCTIVE POLYMER COATINGS - According to one aspect, the present invention provides implantable or insertable medical devices that comprise a substrate and a coating over the substrate that comprises at least one type of conductive polymer and at least one type of additional polymer. | 02-18-2010 |
20100063583 | USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF INFLAMMATORY VASCULAR DISEASES - Disclosed herein are compositions and methods for treating inflammatory vascular diseases. Examples of inflammatory vascular disease include, but are not limited to, in-stent stenosis, coronary arterial diseases (CAD), angina, acute myocardial infarction, acute coronary syndrome, chronic heart failure (CHF), peripheral arterial occlusive diseases (PAOD), critical limb ischemia (CLI), cardiac, kidney, liver and intestinal ischemia, renal failure, cardiac hypertrophy, atherosclerosis, abdominal aortic aneurysm, vasculitis, carotid artery stenosis. | 03-11-2010 |
20100125328 | BIOABSORBABLE STENT - A medical device includes a support structure formed of a metal that is absorbable by a mammalian body. A polymer is disposed on the support structure in at least partially overlying relationship. The polymer has a thickness and a rate of absorption by a mammalian body such that said polymer is substantially completely absorbed, exposing the underlying portion of the support structure, before the underlying portion of the support structure is absorbed. In another embodiment, the medical device includes a support structure formed of a first material, the first material being absorbable by a mammalian body. An absorption inhibitor disposed on the support structure in at least partially overlying relationship and formed of a second material different from the first material. The second material being absorbable by the mammalian body The absorption inhibitor reducing a rate of absorption of the portion of the support structure. | 05-20-2010 |
20100137975 | ACTIVE-SUBSTANCE-COATED MEDICAL PRODUCT, METHOD FOR ITS PRODUCTION AND ITS USES - The present invention relates to a medical product that can be implanted or introduced into a vascular system of a human or animal organism, having an active substance coating according to the invention on the surface of the medical product, to a method for the production of a medical product that can be implanted or introduced into a vascular system of a human or animal organism, having an active substance coating according to the invention, to an active substance coating according to the invention for a medical product that can be implanted or introduced into a vascular system of a human or animal organism, to uses of the active substance coating according to the invention for the production of a medical product that can be implanted or introduced into a vascular system of a human or animal organism, and to a method for treatment of a stenosis, etc., in the vascular system of a human or animal organism. | 06-03-2010 |
20100145436 | Bio-erodible Stent - Endoprostheses such as stents are disclosed that are, or that include portions that are, bioerodible. | 06-10-2010 |
20100191323 | BIODEGRADABLE STENT GRAFT - A stent may help to reconstruct tissue in a vessel by causing the tissue to re-epithelialize. The stent may include a biodegradable frame and a sheet that coats the frame. The sheet may contain a biological material and may flex in unison with the frame in a radial direction. When placed in a vessel, the stent may at least partially conform to at least a portion of a vessel wall. The stent may be capable of being absorbed over a period of time, such as five years, one year, or six months. The stent may flex as the vessel wall dilates and constricts. The stent may be placed in any type of vessel including an artery and mobile vessels. The biodegradable frame may be made of a poly-lactide and/or magnesium. The sheet may contain a biological material including biologic arterial graft and/or an acellular dermal matrix. | 07-29-2010 |
20100222872 | Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers - Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed. | 09-02-2010 |
20100249912 | Intraluminal device with controlled biodegradation - An intraluminal device with controlled biodegradation is provided. The intraluminal device comprises a biodegradable tubular main body. An outer photodegradable layer is disposed over at least a portion of the intraluminal device. The photodegradable outer layer is chemically inert to the body fluids of the implanted region, thereby preventing premature biodegradation of the stent. Degradation of the outer photodegradable layer after a predetermined time occurs by irradiating the layer with UV light waves. After removal of the outer photodegradable layer, the tubular main body becomes exposed to its in vivo environment, thereby allowing biodegradation of the tubular main body. | 09-30-2010 |
20100331963 | Method of Making Suture-Less Hollow Scaffolds - A method of making a hollow organ tissue engineering scaffold for repairing organs. Specifically, the hollow organ tissue engineering scaffold is made from a nonwoven fabric having first and second biocompatible materials, wherein the first material has a lower melting temperature than the first, and the first material is at least partially melted to form the scaffolds. | 12-30-2010 |
20110022158 | Bioerodible Medical Implants - A medical implant includes a bioerodible portion adapted to degrade under physiological conditions. The bioerodible portion includes a bioerodible metal matrix and a salt or clay within the bioerodible metal matrix. | 01-27-2011 |
20110046721 | Biodegradable Metal-Polymer Composite Constructs For Implantable Medical Devices - Embodiments of the invention include biodegradable composites and medical devices including the same. In an embodiment the invention includes a biodegradable implantable medical device. The implantable medical device can include a biodegradable composite member including a polymeric matrix and a reinforcing metal disposed within the polymeric matrix. The biodegradable composite member can be configured to erode in vivo. In an embodiment the invention includes a method of making a biodegradable implantable device including contacting a polymer mixture with a reinforcing metal, the polymer mixture comprising a polymer that degrades under in vivo conditions and the reinforcing metal comprising a metal that produces substantially non-toxic erosion products. Other embodiments are included herein. | 02-24-2011 |
20110301694 | METALLIC IMPLANT WHICH IS DEGRADABLE IN VIVO - The invention relates to a medical implant made of a metallic material. After fulfilling its temporary support function, the implant is degraded by corrosion at a predetermined rate. Negative long-term effects are thus avoided. | 12-08-2011 |
20120065726 | BIOERODIBLE ENDOPROSTHESES AND METHODS OF MAKING THE SAME - A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects. | 03-15-2012 |
20120089221 | BIOABSORBABLE STENT WITH LAYERS HAVING DIFFERENT DEGRADATION RATES - A bioabsorbable stent and method of forming the same including a stent scaffolding formed from polymer layers with different degradation rates is disclosed. The polymer layers include an abluminal layer, a luminal layer, and optionally one or more middle layers. A degradation rate of the layers increases from the luminal layer to the abluminal layer. | 04-12-2012 |
20120116501 | Biodegradable Drug Delivery Material For Stent - A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom. | 05-10-2012 |
20120150282 | IMPLANT HAVING A PACLITAXEL-RELEASING COATING - An implant having a coating or a cavity filling comprising a PLGA polymer and taxane embedded therein, the release rate of the taxane after day two after implantation being ≦400 ng/day for a period of more than 10 consecutive days, characterized in that the PLGA polymer has a ratio of monomer units to each other of 60-99% lactic acid units to 40-1% glycolic acid units. | 06-14-2012 |
20120150283 | METHOD OF MAKING A STENT FORMED FROM CROSSLINKED BIOABSORBABLE POLYMER - A stent having a stent body made from a crosslinked bioabsorbable polymer is disclosed. A method of making the stent including exposing a tube formed from a bioabsorbable polymer to radiation to crosslink the bioabsorbable polymer and forming a stent body from the exposed tube is disclosed. The tube can include a crosslinking agent which induces crosslinking upon radiation exposure. Additionally or alternatively, the bioabsorbable polymer can be a copolymer that crosslinks upon exposure to radiation in the absence of a crosslinking agent. | 06-14-2012 |
20120330404 | Elastomeric Copolymer Coatings For Implantable Medical Devices - Implantable medical devices with elastomeric copolymer coatings are disclosed. | 12-27-2012 |
20130030518 | COATED DEVICES AND METHOD OF MAKING COATED DEVICES THAT REDUCE SMOOTH MUSCLE CELL PROLIFERATION AND PLATELET ACTIVITY - The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient. | 01-31-2013 |
20130035755 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE - The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ. | 02-07-2013 |
20130035756 | VASCULAR STENT HAVING A DUAL COATING STRUCTURE - Disclosed is a vascular stent which is inserted inside a blood vessel. The disclosed vascular stent includes: a first coating film comprising a restenosis inhibiting drug provided on the outside surface of the stent strut; and a second coating film comprising an internal-capsule cellularization promoting drug provided on the inside surface of the stent strut. In this way, restenosis and thrombosis can be prevented from occurring inside the stent. | 02-07-2013 |
20130060326 | IMPLANT MADE OF A BIODEGRADABLE MAGNESIUM ALLOY - An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li:0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight. | 03-07-2013 |
20130066417 | BIODEGRADABLE STENT - Degradable pure iron stent or iron alloy stent is provided. The stent is made containing 0.01 to 0.5 atom % of La, Ce or Sr. The stent is surface modified using ion implantation or plasma ion implantation to implant oxygen, nitrogen, La, Ce or Sr into the stent surface. The stent may also be manufactured by depositing a thin film of La, Ce, Sr, lanthana, ceria, strontia, iron or iron oxide onto the stent surface. The thickness of the deposited films is from 10 to 1000 nanometers with the grain size from 10 to 200 nanometers. The corrosion resistance of these stents is significantly increased, and the stents have good biocompatibility. The degradation of the stents is controllable. The stents can also provide sufficient support in blood vessel in 3-6 months after intervention and be degraded after 6 months. | 03-14-2013 |
20130138206 | PEDIATRIC APPLICATION OF BIOABSORBABLE POLYMER STENTS IN INFANTS AND CHILDREN WITH CONGENITAL HEART DEFECTS - Methods of treating congenital heart defects in infants and children with bioabsorbable polymer stents are described. The treatments reduce or eliminate the adverse affects of congenital heart defects or may be palliative. | 05-30-2013 |
20130150953 | Kits Including Implantable Medical Devices and Antioxidants - Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices. | 06-13-2013 |
20130184809 | Disintegrating stent and method of making same - A temporary stent endoprosthesis that does not require an interventional procedure for removal. The disintegrating stent is preferably made from a bioabsorbable polymer, such as by braiding polymer monofilaments into a tubular mesh shape, and the polymer has fracture initiation sites within it that promotes the disintegration of the stent into small pieces that are harmlessly transported out of the body by the vessel contents. Fracture initiation sites may be created by controlling the heterogenous structure of amorphous and crystalline regions, by introducing internal or surface fracture initiation sites, or use of multiple strands with small section size. | 07-18-2013 |
20130218263 | Medical Device with Regioselective Structure-Property Distribution - A medical device such as a stent having selected regions with different material properties than other regions is disclosed. Selection and modification of the regions may be based on facilitating a desired mechanical behavior and/or therapeutic prophylactic property of the device. | 08-22-2013 |
20130261736 | MULTILAYER BIOABSORBABLE SCAFFOLDS AND METHODS OF FABRICATING - A bioabsorbable scaffold composed of a multilayer structure of alternating layers of different polymers is disclosed. The multilayer structure can have 20 to 1000 layers and the individual thickness of the layers can be 0.2 to 5 microns. A method of making the scaffold including a layer multiplying extrusion process is disclosed. | 10-03-2013 |
20130325108 | BIODEGRADABLE MEDICAL IMPLANTS, POLYMER COMPOSITIONS AND METHODS OF USE - Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail. | 12-05-2013 |
20140018907 | POLYMER-BIOCERAMIC COMPOSITE IMPLANTABLE MEDICAL DEVICE WITH DIFFERENT TYPES OF BIOCERAMIC PARTICLES - Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed. | 01-16-2014 |
20140074224 | COATING OF FAST ABSORPTION OR DISSOLUTION - A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided. | 03-13-2014 |
20140142686 | BIODEGRADABLE STENT FORMED WITH POLYMER-BIOCERAMIC NANOPARTICLE COMPOSITE AND METHOD OF MAKING THE SAME - The present invention relates to biodegradable medical devices such as stents manufactured from biodegradable polymeric-bioceramic nanoparticle composites. The invented medical devices include at least one bioceramic nanoparticle dispersed in at least one biodegradable polymer, wherein the said biodegradable polymers include biodegradable polyesters. The device and methods to disperse one or more bioceramic nanoparticle, wherein the said bioceramic nanoparticle include, but are not limited to, amorphous calcium phosphate (ACP), dicalcium phosphate (DCP), tricalcium phosphate (TCP), pentacalcium hydroxyl Apatite(HAp), tetracalcium phosphate monoxide(TTCP) and combinations or analogues thereof. Other embodiments include methods of fabricating biodegradable stent with said polymeric-nanoparticle composites. | 05-22-2014 |
20140180398 | Bioabsorbable Medical Devices and Methods of Use Thereof - One aspect provides implantable medical devices including a bioabsorbable structure having a surface and having a coating layer on at least a portion of the surface. In certain embodiments, the coating layer includes a releasable bioactive and provides for a controlled absorption of the bioabsorbable structure upon implantation in a human or veterinary patient. Another aspect provides methods treating a disease including implanting such a device in a vessel of a human or veterinary patient. | 06-26-2014 |
20140222133 | MAGNESIUM ALLOY AND RESORBABLE STENTS CONTAINING THE SAME - The present invention is directed to a magnesium alloy comprising dysprosium, being degradable under physiological conditions and which is particularly suitable for the production of absorbable stents and to stents made thereof. | 08-07-2014 |
20140236284 | Bioerodible Magnesium Alloy Microstructures for Endoprostheses - A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes. | 08-21-2014 |
20140236285 | STENT FABRICATION VIA TUBULAR CASTING PROCESSES - Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape. | 08-21-2014 |
20140257465 | STENTS HAVING CONTROLLED ELUTION - Provided herein is a device comprising a stent and a coating on the stent; wherein the coating comprises at least one polymer and at least one active agent; wherein at least part of the active agent is in crystalline form. | 09-11-2014 |
20140277396 | Bioabsorbable Stent With Hydrothermal Conversion Film and Coating - A stent includes a bioabsorbable metal, a hydrothermal conversion film covering the bioabsorbable metal, and a coating covering the hydrothermal conversion film. A method for manufacturing a stent includes forming a stent body comprising a bioabsorbable metal, forming a hydrothermal conversion film over surfaces of the stent body, and coating the hydrothermal conversion film with an overcoat. | 09-18-2014 |
20140309725 | OPTIMIZED DRUG-ELUTING STENT ASSEMBLY - A stent assembly including a stent configured to be positioned in a body lumen, and a knitted stent jacket including an expansible mesh structure having a coverage area of less than 25%, having approximate aperture diameters greater than 20 micrometers, and surrounding an external surface of the stent and coaxially associated therewith, wherein the stent assembly elutes an amount of an active pharmaceutical agent. | 10-16-2014 |
20140324158 | BIOSORBABLE ENDOPROSTHESIS - A biosorbable magnetisable endoprosthesis, may be useful in the therapy of restenosis. A method for the treatment of prevention of restenosis or a disease of thecoronary artery, comprises fitting a patent with an endoprosthesis according to the invention, which has either been magnetized prior to placement in the body or which is magnetized in situ, and administering to the patient magnetized cells capable of repairing an artery. | 10-30-2014 |
20140343667 | BIOABSORBABLE BIOMEDICAL IMPLANTS - A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 150 μm. Methods for making the bioabsorbable biomedical implant, including the methods for making the fiber-reinforced polymer composite materials for the tubular scaffold, are also disclosed. | 11-20-2014 |
20140379072 | Tissue-Engineered Vascular Graft and Its Fabrication Approach - Tissue-engineered vascular graft is designed to be used in cardiovascular surgeries, especially in coronary artery bypass grafting and peripheral vessels reconstruction procedures. Two-phase electrospinning technique was employed to fabricate a biodegradable polymer graft composed of the porous tubular scaffold supplemented by biologically active molecules, incorporated directly into the matrix walls in order to promote regeneration process of the patient's own vessel wall. | 12-25-2014 |
20150025619 | BIODEGRADABLE ENDOPROSTHESES AND METHODS FOR THEIR FABRICATION - The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen. | 01-22-2015 |
20150045876 | DISSOLVABLE OR DEGRADABLE ADHESIVE POLYMER TO PREVENT STENT MIGRATION - A stent having an inner surface and an outer surface, at least a portion of the outer surface of the stent comprising a dissolvable adhesive polymer or a degradable adhesive polymer disposed on at least a portion of the outer surface of the stent, the adhesive is activated by exposure to an aqueous environment, the dissolvable adhesive polymer dissolves over time in an aqueous environment, the dissolvable adhesive polymer or the degradable adhesive polymer has a surface tack of about 2 psi to about 14 psi. | 02-12-2015 |
20150057745 | METHODS OF TREATMENT WITH DRUG DELIVERY AFTER BIODEGRADATION OF THE STENT SCAFFOLDING - Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots. | 02-26-2015 |
20150066135 | Bioerodible Composites for Endoprostheses - A bioerodible endoprosthesis includes a composite including a matrix comprising a bioerodible magnesium alloy and a plurality of ceramic nanoparticles within the matrix. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns. The microstructure can be produced by one or more equal-channel high-strain processes. | 03-05-2015 |
20150073535 | Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina - Methods of treating coronary artery disease (CAD) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed. | 03-12-2015 |
20150073536 | Assessment of a drug eluting bioresorbable vascular scafford - A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment. | 03-12-2015 |
20150094798 | BIORESORBABLE MEDICAL DEVICES AND METHOD OF MANUFACTURING THE SAME - An intermixed particulate bioresorbable material including cathodic particles and anodic particles bound to each other, wherein the anodic and cathodic particles are made respectively of an anodic and a cathodic material, the anodic and cathodic materials forming a galvanic couple. The anodic and cathodic particles are present in a predetermined ratio and the anodic particles, cathodic particles and predetermined ratio are such that bioresorption of said stent is promoted by galvanic corrosion between said anodic and cathodic materials. Also, a medical device, such as a stent, manufactured using the bioresorbable material and a method of manufacturing the bioresorbable material and the medical device. | 04-02-2015 |
20150119976 | EXTRAVASCULAR DEVICE FOR LIMITING BLOOD FLOW ADJACENT AN ARTERIOVENOUS FISTULA - A medical device that can be wrapped around a segment of an artery downstream of an arteriovenous fistula. The wrap, when used in this manner, creates a stenosis for reducing retrograde flow at the fistula. Sutures are positioned in holes present in the upper and lower halves or connecting ends of the wrap, after which the sutures are pulled to oppose the two sides in order to create a stenosis. When the surgeon is satisfied that the stenosis is appropriate, the sutures are tied in place. | 04-30-2015 |
20150313735 | Bioabsorbable Stent and Treatment That Elicits Time-Varying Host-Material Response - Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters. | 11-05-2015 |
20150352261 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE - The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ. | 12-10-2015 |
20150359648 | HIGH MOLECULAR WEIGHT POLYLACTIDE AND POLYCAPROLACTONE COPOLYMER AND BLENDS FOR BIORESORBABLE VASCULAR SCAFFOLDS - Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state. | 12-17-2015 |
20160022408 | Decellularization Method and System and Decellularized Tissue Formed Thereby - Systems and methods that establish a pressure differential across a tissue wail to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time. | 01-28-2016 |
20160038315 | TREATMENT OF CARDIAC DISEASES THAT PROMOTE EPICARDIAL ARTERY ENLARGEMENT WITH BIORESORBABLE SCAFFOLDS - Methods of treating coronary artery disease (CAD) and a cardiac disease that stimulates enlargement of the epicardial artery with a bioresorbable scaffold in a patient in need thereof are disclosed. Methods of treating CAD and an event that precipitates enlargement of the epicardial artery with a bioresorbable scaffold in a patient in need thereof are disclosed. | 02-11-2016 |
20160128825 | TISSUE ENGINEERING OF BLOOD VESSELS - Method and apparatus for mapping the shape and dimensions of a 3-dimensional body, by applying to the 3-dimensional body a stretchable covering configured and dimensioned such that in its stretched condition it tightly engages and conforms to the shape and dimensions of the 3-dimensional body to be mapped. The stretchable covering carries a plurality of reference devices, such as bands and/or markers which are at know or determinable reference locations in an initial condition of the covering, and which change their locations in the stretched condition of the stretchable covering according to the shape and dimensions of the 3-dimensional body covered thereby. The locations of the markers on the stretchable covering are determined after the stretchable covering has been applied to the 3-dimensional body, and are utilized to produce a map of the shape and dimensions of the 3-dimensional body. | 05-12-2016 |
20160157988 | DRUG DELIVERY DEVICE FOR PERIPHERAL ARTERY DISEASE - A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces. | 06-09-2016 |
20160157989 | Graft Devices and Methods of Fabrication - A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft device between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion. | 06-09-2016 |
20160374838 | DRUG-ELUTING COATINGS ON POLY(DL-LACTIDE)-BASED SCAFFOLDS - Stents including a poly(D,L-lactide)(PDLLA)-based scaffold and PDLLA based therapeutic layer are disclosed. The PDLLA based scaffold may be amorphous and may include a primer layer. Methods of applying the PDLLA-based coating to the scaffold are disclosed with solvent processing methods using a solvent blend are also disclosed. Methods of removing residual solvent from a PDLLA-base coating that also condition the scaffold are disclosed. Methods of treating restenosis that release drugs to prevent restenosis without interfering with the natural positive remodeling of a vessel are disclosed. | 12-29-2016 |