| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 623100410 | Having living cell | 26 |
| 20080234801 | SYSTEMS AND METHODS OF PROMOTING ENGRAFTMENT OF A HYBRID CAROTID BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote engraftment of a hybrid carotid bypass vascular graft following implantation into a mammal's body by placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention prior to implantation of the hybrid carotid bypass vascular graft into the mammal's body. | 09-25-2008 |
| 20080234802 | SYSTEMS AND METHODS OF COATING A HYBRID CAROTID BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holders where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid carotid bypass vascular graft with a confluent monolayer of endothelial cells by immobilizing a plurality of endothelial cells on the hybrid carotid bypass vascular graft and placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention under conditions effective to promote the endothelial cells to form a confluent monolayer on the surface of the hybrid vascular graft. | 09-25-2008 |
| 20080234803 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID CAROTID BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid carotid bypass vascular graft by placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention under conditions effective to promote stem cells to differentiate into endothelial cells on a surface of the hybrid carotid bypass vascular graft. | 09-25-2008 |
| 20080234804 | SYSTEMS AND METHODS OF COATING A HYBRID CAROTID BYBASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid graft with a confluent monolayer of endothelial cells by immobilizing stem cells on a hybrid carotid bypass vascular graft, placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the stem cells to form a confluent monolayer on the surface of the hybrid vascular graft and in an environment to promote the stem cells to differentiate into endothelial cells. | 09-25-2008 |
| 20080234805 | HYBRID LOWER LIMB ARTERY BYPASS GRAFTS AND SYSTEMS AND METHODS FOR PRODUCING OR MODIFYING THE SAME - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can prepare a hybrid lower limb artery bypass vascular graft intended for implantation into a mammal by placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention prior to implantation of the hybrid lower limb artery bypass vascular graft into the mammal. | 09-25-2008 |
| 20080234806 | SYSTEMS AND METHODS OF COATING A HYBRID LOWER LIMB ARTERY BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid lower limb artery bypass vascular graft with a confluent monolayer of endothelial cells by immobilizing a plurality of endothelial cells on the hybrid lower limb artery bypass vascular graft and placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention under conditions effective to promote the endothelial cells to form a confluent monolayer on the surface of the hybrid vascular graft. | 09-25-2008 |
| 20080234807 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID LOWER LIMB ARTERY BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid lower limb artery bypass vascular graft by placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention under conditions effective to promote stem cells to differentiate into endothelial cells on a surface of the hybrid lower limb artery bypass vascular graft. | 09-25-2008 |
| 20080243235 | CELLULAR TRANSPLANT STENT - A cellular stent carries living therapeutic cellular material for implantation into a human or animal body and allows either localized or systemic delivery of the therapeutic products, while promoting engraftment, either on a tissue surface or its interior. The cells are contained within wells in the stent that are enclosed by inner and outer membranes that seal the cellular material within the stent until it is to be released. The outer membrane is preferably in the form of a thin, hard plastic sheet having a plurality of score lines, perforations, or other lines or weakening provided therein. The membrane may be embedded in a softer perimetral mount which retains it in position until the seal is to be broken. Rupture of the outer membrane ensures penetration of the cells into the interior of tissue or an organ in which the stent is implanted. | 10-02-2008 |
| 20080243236 | Method of conditioning a hybrid synthetic tubular structure to yeild a functional human hybrid hemodialysis access graft - A method of yielding a functional human hybrid hemodialysis access graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on at least one surface to yield the functional human hybrid hemodialysis access graft. Specifically, the method includes placing the hybrid synthetic tubular structure in a system capable of producing three dimensional dynamic conditions for a sufficient time to yield said functional human hybrid hemodialysis access graft. | 10-02-2008 |
| 20080243237 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID CAROTID BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid carotid bypass vascular graft by placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention under conditions effective to promote stem cells to form a confluent monolayer on the hybrid vascular graft. | 10-02-2008 |
| 20080243238 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID LOWER LIMB ARTERY BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid lower limb artery bypass vascular graft by placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid vascular graft. | 10-02-2008 |
| 20080243239 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID HEMODIALYSIS ACCESS GRAFT OR A HYBRID FEMORAL ARTERY BYPASS GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holders where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote stem cells to form a confluent monolayer on the hybrid graft. | 10-02-2008 |
| 20080262605 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID HEMODIALYSIS ACCESS GRAFT OR A HYBRID FEMORAL ARTERY BYPASS GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft. | 10-23-2008 |
| 20090105811 | Intravascular Devices for Cell-Based Therapies - Disclosed herein are vascular cell encapsulation devices that can deliver cell type(s) for the treatment of a disease or disorder. | 04-23-2009 |
| 20090248145 | METHOD OF FORMING A THREE-DIMENSIONAL STRUCTURE OF UNIDIRECTIONALLY ALIGNED CELLS - The present invention provides a method of forming a three-dimensional structure of unidirectionally aligned cells. The method comprises providing a substrate with a microchannel. The microchannel is defined by at least a pair of opposing lateral walls and a base. In at least a portion of the microchannel the distance between the pair of opposing lateral walls is within the micrometer range. A first plurality of cells is seeded in the microchannel and the cells are allowed to proliferate up to at least a density of at least 90%. Thereby contact guidance cues are provided by the pair of opposing lateral walls of the microchannel, such that the cells align unidirectionally. Thereby a first layer of aligned cells is also formed at the base of the microchannel. A second plurality of cells is seeded in the microchannel, which already comprises a first layer of aligned cells. When allowing cells of the second plurality of cells to proliferate up to at least substantial confluence, contact guidance cues are again provided by the lateral walls of the microchannel. The cells also align unidirectionally and form a second layer of aligned cells. | 10-01-2009 |
| 20090319033 | METHOD FOR ENDOTHELIAL CELL EXTRACTION FROM ADISPOSE TISSUES - Adipose tissue has proven to serve as an abundant, accessible, and rich source of endothelial or vascular endothelial cells suitable for tissue engineering. We describe a detailed method for the isolation and purification of endothelial cells using purified enzymes and antibody-based selection. The cells can be obtained from liposuction procedures and used in vascular grafts. | 12-24-2009 |
| 20100204783 | METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS - Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality. | 08-12-2010 |
| 20100305687 | NON-WOVEN MAT AND METHO OF PRODUCING SAME - A mat having a highly uniform porosity distribution is produced by consolidating 15 or more layers of melt blown webs (or the like) having different orientations. Control over the porosity is provided by using webs that exhibit a narrow, unimodal distribution of fiber diameters over the bulk of its distribution, such as in the top 80%. A compliance of the mats can be chosen by selecting a number and orientation of the webs. It is thus possible to produce mats that are good candidates for vascular grafts, for example. The uniformity of the porosity within the range of 6 μm to 30 μm permits seeding of the vascular graft with endothelial and smooth muscle cells. The mats have the demonstrated ability to retain, and support growth of, smooth muscle cells and endothelial cells. | 12-02-2010 |
| 20100331964 | Ex Vivo Remodeling of Excised Blood Vessels for Vascular Grafts - The present invention provides an ex vivo vascular remodeling methods and system by which an excised, small diameter blood vessel can be harvested and expanded to provide viable vascular grafts, as demonstrated at the physical and molecular levels, and as optimized in vivo. The tissue-engineered vessels generated by the present invention closely resemble native vessels in terms of structure, histologically, including endothelial coverage and intricate structural components such as the internal elastic lamina, viability (as measured with MTT assay and TUNEL analysis), and function (vasoactivity, mechanical and biomechanical properties). Thus, the resulting vascular grafts behave in a manner similar to native arteries in terms of mechanical integrity, and provide clinically relevant patency rates when implanted in vivo. Moreover, the ex vivo methods and system permit the precise control of the mechanical environment involving the excised vessel, while at the same time permitting carefully monitoring of the resulting growth/remodeling, thereby opening new avenues of research regarding the mechanical stimuli responsible for specific aspects of remodeling in vivo. | 12-30-2010 |
| 20110015723 | ADJUSTABLE STENOSIS AND METHOD THEREFOR - An adjustable stenosis provides a channel comprising an outer wall and an inner wall. The inner wall may comprise resiliently flexible material. A reservoir may be formed by the outer wall and inner wall. The flexibility of the inner wall allows the reservoir to expand into the channel to increase stenosis and to contract toward the outer wall to decrease stenosis. The reservoir may have a default expanded shape or a default contracted shape. The default shape may be maintained unless the pressure or amount of filler material in the reservoir is manipulated. The reservoir may have one or more chambers. The channel may be attached to a natural lumen or a graft or may be placed around the lumen or graft. | 01-20-2011 |
| 20110313513 | METHOD AND DEVICES FOR PREVENTING RESTENOSIS IN CARDIOVASCULAR STENTS - Described herein are devices and methods fabricating devices having nanostructures that allow adhesion or growth of one cell type, such as endothelial cells, more than another cell type, such as smooth muscle cells. In particular, stent covers having such nanostructures are described, and methods for fabricating these stent covers. Also described herein are methods for optimizing the nanostructures forming the devices. | 12-22-2011 |
| 20130172985 | CROSSLINKED HYDROGELS AND METHODS OF MAKING AND USING THEREOF - Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein. | 07-04-2013 |
| 20130289715 | MULTILAYERED IMPLANT MATERIALS DERIVED FROM AMNIOTIC MEMBRANE, METHODS OF MAKING THE MULTILAYERED IMPLANT MATERIALS, AND METHOD OF USING MULTILAYERED IMPLANT MATERIALS - Exemplary embodiments of the present disclosure provide for multi-layered implantation materials, methods of making a multi-layered implantation material, methods of forming a multi-layered implantation material, methods of forming a multi-layered implantation material having a spiral roll cross-section, and the like. | 10-31-2013 |
| 20150012083 | TUBULAR TISSUE-ENGINEERED CONSTRUCTS - The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs. | 01-08-2015 |
| 20150094799 | Extracellular Matrix Prostheses for Treating Damaged Biological Tissue - Mufti-sheet laminate structures having a first extracellular matrix (ECM) sheet member having a top cross-linked surface and a second ECM sheet member having a bottom surface, the second ECM sheet member being joined to the first ECM sheet member, wherein the first ECM sheet member top cross-linked surface is disposed proximate the second ECM sheet member bottom surface. | 04-02-2015 |
| 20150342720 | ARTIFICIAL HOLLOW BIOLOGICAL TISSUE NETWORK AND METHOD FOR PREPARATION THEREOF - A network ( | 12-03-2015 |
