| Entries |
| Document | Title | Date |
|---|
| 20080199950 | Enhanced Bio-Assays By Using Gradient Nanotopgraphy - ABSTRACT A system and method for using gradient nanotopography to increase mammalian cell attachment and cell confinement on surfaces. A surface platform consisting of a thin film of gold possessing a gradient of topography on the surface and self-assembled monolayers of alkanethiols presenting desired functional groups is formed. A gradient in the chemical properties is induced in the terminal groups of the monolayer because of the continuous increase in the surface area and the anisotropy of gold film structure. The gradient nanotopraphy provides simultaneous control of two key properties, the presentation of the terminal functional groups and a continuous increase in the surface density of functional groups on the surface. This control provides for drug screening assays using adherent cell-based experiments. | 08-21-2008 |
| 20080227189 | Device for Pressurized Perfusion Especially for Culturing and/or Treating Cells - The invention relates to a device for pumping a fluid into a bioreactor. Polsatile pumping is made possible by valve arrangement so that growth of the cells in the bioreactor is increased. Pumping function can be achieved though several mechanisms. A piston can be displaced in a cylinder, especially by an electromagnet, wherein a permanent magnet or likewise an electromagnet can be arranged in the piston. The piston can also be displaced by compressed air. An elastic, hollow body can also be provided, wherein said hollow body can be deformed by mechanical electromagnetic forces so that pumping function is achieved by a change in volume. The pumping device can also be used as implant for assisting or replacing heart function. | 09-18-2008 |
| 20080254533 | Cell Expansion System and Methods of Use - Cell expansion systems are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second fluid flow paths associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. The hollow fibers have a hydrophilic interior surface and a hydrophobic exterior surface. Detachable flow circuits are also provided. | 10-16-2008 |
| 20080261299 | Pneumatic Bioreactor - A pneumatic bioreactor having a containment vessel which includes a semi-cylindrical concavity defined by the vessel bottom. A mixing apparatus includes a rotational mixer rotatably mounted within the containment vessel about a horizontal axis. The rotational mixer has buoyancy-driven mixing cavities which are fed by a gas supply beneath the rotational mixer. The mixing apparatus extends into the semi-cylindrical concavity to substantially fill that concavity. The rotational mixer is divided into two wheels with outer paddles extending axially outwardly and inner paddles extending axially inwardly on either side of each ring. Blades between the outer and inner paddles form impellers in the wheels to induce axial flow through the rings in opposite directions. The containment vessel may be of film and supported by a structural housing also having a semi-cylindrical concavity defined by the housing bottom. | 10-23-2008 |
| 20080268529 | Container for Nucleic Acid Amplification, Nucleic Acid Preparation Kit and Nucleic Acid Analyzer - The present invention relates to a technique of amplifying a target nucleic acid contained in a specimen, and further to a technique of analyzing the amplified target nucleic acid. The present invention provides a nucleic acid amplification container ( | 10-30-2008 |
| 20080268530 | Pneumatic Bioreactor - A pneumatic bioreactor having a containment vessel which includes a semi-cylindrical concavity defined by the vessel bottom. A mixing apparatus includes a rotational mixer rotatably mounted within the containment vessel about a horizontal axis. The rotational mixer has buoyancy-driven mixing cavities which are fed by a gas supply beneath the rotational mixer. The mixing apparatus extends into the semi-cylindrical concavity to substantially fill that concavity. The rotational mixer is divided into two wheels with outer paddles extending axially outwardly and inner paddles extending axially inwardly on either side of each wheel. Blades between the outer and inner paddles form impellers in the wheels to induce axial flow through the wheels in opposite directions. Stationary baffles fixed relative to the containment vessel are inclined toward the rotational mixer in the direction of rotation. The containment vessel may be of film and supported by a structural housing also having a semi-cylindrical concavity defined by the noosing bottom. | 10-30-2008 |
| 20080274541 | Disposable bioreactor system - A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force. | 11-06-2008 |
| 20080293131 | Culture observation equipment - The present application includes a culture chamber, an observation chamber having an optical system of observation to observe samples to be cultured in the culture chamber, and a movement stage provided at a boundary which separates the culture chamber and the observation chamber, functioning as a wall to maintain an environment of both of the chambers, bearing the samples, and moving the samples on a light axis of observation of the optical system of observation. Due to such an arrangement, a culture observation equipment which has good response and excellent environmental resistance can be achieved, preventing problems such as the overall size of the device became large, maintenance work was difficult, and device cost became expensive. | 11-27-2008 |
| 20080305539 | MEMBRANE SUPPORTED BIOREACTOR FOR CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS - Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO | 12-11-2008 |
| 20090004731 | Cell culture apparatus and a fabricating method of the same - A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenol A and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), α,α-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition. | 01-01-2009 |
| 20090035847 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR NUCLEIC ACID DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - Provided are a centrifugal force-based microfluidic device for separating and amplifying a nucleic acid of a target cell and a microfluidic system including the same. The microfluidic device includes a rotary platform; a target cell nucleic acid extraction unit; and a polymerase chain reaction (PCR) unit wherein in a microfluidic structure arranged in the platform and connected to the target cell nucleic acid extraction unit. | 02-05-2009 |
| 20090053800 | Biomass Treatment Apparatus - An apparatus was developed for treatment of biomass in which reactants are added to biomass and the biomass mixture is moved through the apparatus without compacting under force of a non-compacting piston. Treatment systems used in this reactor result in effectively treated biomass that is particularly suitable for subsequent saccharification to produce fermentable sugars. | 02-26-2009 |
| 20090053801 | Shallow multi-well plastic chip for thermal multiplexing - Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limitation has been overcome by forming a disposable plastic chip using a simple deformation process wherein one or more plastic sheets are caused, through hydrostatic pressure, to conform to the surface of a suitable mold. After a given disposable chip has been filled with liquid samples, it is brought into close contact with an array of heating blocks that seals each sample within its own chamber, allowing each sample to then be heat treated as desired. | 02-26-2009 |
| 20090061508 | Laminar flow reactor - A Laminar Flow reactor for large scale culturing or packaging of cell suspensions, three-dimensional tissue and other biological systems is disclosed. The Laminar Flow reactor consists of an upper housing and a lower housing. The housings are interconnected by a plurality of connectors and a plurality of rigid spacers, an inlet fluid, an outlet fluid, a fluid reservoir, and a means for transporting fluid within the system. During treatment, liquid media is transported from the fluid reservoir to the inlet manifold, which will in turn evenly distribute the media to each of the connected connectors and internal culture pockets. Laminar flow through the device is maintained by the cylindrical shape of the device and by bypasses. An outlet fluid manifold is also provided to ensure that each treatment chamber is evenly filled and to ensure that any air bubbles formed during treatment are removed from the treatment chambers. | 03-05-2009 |
| 20090075362 | Disposable Bioreactor Comprising a Sensor Arrangement - The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter ( | 03-19-2009 |
| 20090075363 | CELL CULTURE CONTAINER AND METHOD OF PRODUCING THE SAME - To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern includes cell culture portions and micro flow channels communicating with the cell culture portions. The bottom surface of each of the cell culture portions has a width 1.0 to 20 times an equivalent diameter of each of the cultured cells. A cell adhesion-inducing substance is formed only on the bottom surface and the side walls of the concave portion. | 03-19-2009 |
| 20090081770 | HIGH THROUGHPUT BIOREACTOR - A continuous flow bioreactor system that includes a bioreactor, an optional post-bioreactor preparation chamber, a cell sorter, and an optional pre-bioreactor preparation chamber in a closed loop, useful for enriching a heterogeneous cell population growing in the bioreactor with an isolated subpopulation of cells. | 03-26-2009 |
| 20090117647 | METHOD FOR ON-LINE OPTIMIZATION OF A FED-BATCH FERMENTATION UNIT TO MAXIMIZE THE PRODUCT YIELD - A method for on-line optimization of fed-batch fermentation unit containing bacteria and nutrients is disclosed. Parameters of the fermenter model used in optimization calculations are estimated periodically to reduce the mismatch between the plant and the calculated values. The updated fermenter model is used to calculate the optimum sugar feed rate to maximize the product yield. The method/fermenter model is implemented as a software program in a PC that can be interfaced to plant control systems for on-line deployment in an actual plant environment. An on-line optimization system is useful to the plant operating personnel, to maximize the product yield from the fed-batch fermenter unit. In another aspect, a plant control system to control a fed-batch fermentation based on the described method is also disclosed. | 05-07-2009 |
| 20090155892 | BIOREACTOR COMPRISING A RETAINING SYSTEM - Disclosed is a bioreactor in which a supporting wall ( | 06-18-2009 |
| 20090155893 | Methods and Apparatus for Amplification of DNA Using Sonic Energy - Apparatus and methods for amplification of DNA are provided that use sonic energy in place of conventional thermocyclers. In one embodiment, sonic energy is applied to a PCR cocktail to effect dissociation of double stranded DNA into single strands of DNA. A quiescence stage, where no sonic energy is applied, results in amplification of DNA. Repetition of the cycles of application of sonic energy and cessation of application of sonic energy results in DNA amplification. | 06-18-2009 |
| 20090162928 | INTEGRATED SAMPLE PROCESSING DEVICES - Sample processing devices may include compression structures that provide for the transfer of force from a platen to a platform such as a thermal block on which the sample processing device is located during processing. The sample processing devices may include a fill reservoir structure with various features such as arcuate edges, radially aligned exit channels, support structures, and selectively variable heights with a corresponding variable volume distribution. | 06-25-2009 |
| 20090215162 | Nucleic acid amplification device - This invention provides a nucleic acid amplification device whereby the abundance of a target molecule can be maintained before and after a step of separately amplifying a sample such that highly accurate analysis results that can be applied to gene expression analysis can be obtained. Also, a nucleic acid amplification device having a structure in which a plurality of minute reaction cells each comprising a set of a bead-retaining space capable of retaining a single analysis bead and a reagent reaction space retaining no bead but having a volume that is large enough to cause a reagent reaction therein are positioned so as to form a planar face is provided. | 08-27-2009 |
| 20090239291 | CULTURE VESSEL ALLOWING LARGE IN SITU SCALE UP - The present invention, in one aspect, provides a culture vessel which includes a body having at least a first edge at least partially perimetrically bounding the body, and at least a first seal extending from the first edge. The first seal is breachable and fluid-tight, and disposed obliquely to the first edge so as to subtend an acute angle therewith. The first seal separates the body into first and second chambers. Advantageously, with the subject invention, a culture vessel is provided which allows for volume expansion in situ. | 09-24-2009 |
| 20090263892 | Float valve for cell culture vessel - A cell culture vessel includes a housing defining a reservoir, an inlet and an outlet in fluid communication with the reservoir, a valve assembly, and an antimicrobial filter. The valve assembly includes (i) a side wall defining a passageway for fluid flow between the reservoir and the outlet, (ii) a floating element disposed in the passageway and configured to float on the culture medium, (iii) a stop feature configured to sealingly engage the floating element to prevent the culture medium from flowing from the reservoir through the outlet, and (iv) a capture feature configured to retain the floating element within the passageway and to allow fluid to flow from the reservoir through the passageway. The microbial filter is positioned such that air flowing in the outlet to the passageway passes through the filter. | 10-22-2009 |
| 20090269839 | Process of Producing Oil from Algae Using biological Rupturing - A process for production of biofuels from algae can include cultivating an oil-producing algae, extracting the algal oil, and converting the algal oil to form biodiesel. Extracting the algal oil from the oil-producing algae can include biologically rupturing cell wall and oil vesicles of the oil-producing algae using at least one enzyme such as a cellulose or glycoproteinase, a structured enzyme system such as a cellulosome, a virus, or combination of these materials. | 10-29-2009 |
| 20090311775 | Disposable Bioreactor for Culturing Cells in a Nutrient Medium - Disposable bioreactor for culturing cells in a nutrient medium, consisting of a reagent container which is sealable with a lid and which is capable of being subjected to a shaking process in a shaking device, where the reagent container is equipped with at least one web adjacent to the internal wall of the container, the web being arranged running vertically from the bottom upward, preferably in the shape of a helix. | 12-17-2009 |
| 20090311776 | Stirred tank bioreactor - The present invention is a disposable bioreactor formed of molded plastic. The bioreactor is presterilized and has a top and body sealed to each other. One or more ports are formed in the top and side of the housing. Preferably at least one port is below the liquid/air level for the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports or access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment location is also guaranteed through the use of the molded port features. The molded plastic allows for greater flexibility in material selection to reduce or eliminate lipid or cholesterol binding. | 12-17-2009 |
| 20100003745 | CELL CULTURE VESSEL - A cell culture vessel for culturing adherent cells includes a channel allowing liquid to flow therethrough; a culture surface disposed on a wall of the channel, the culture surface allowing the adherent cells to adhere thereto; an inlet for introducing the liquid into the channel; an outlet for draining the liquid from the channel; a connecting portion communicating with the channel; and a connection receiving portion communicating with the channel. The cell culture vessel is capable of being connected to another cell culture vessel using the connecting portion or the connection receiving portion. When the connecting portion of the cell culture vessel is connected to a connection receiving portion of the other cell culture vessel, the culture surface of the cell culture vessel and a culture surface of the other cell culture vessel form a continuous culture surface. | 01-07-2010 |
| 20100009433 | CULTURING SYSTEM - The problem of a specimen being vibrated during supply or drainage of a liquid such as a culture solution can be avoided, thus allowing acquisition of a stable image. The invention provides a culturing system including a main container having an opening facing upward, accommodating a culture vessel containing a biological specimen, and having an inner space maintained at a predetermined incubation environment; and a nozzle fixed to the main container and inserted into the culture vessel through the opening of the culture vessel to supply or drain a liquid into or from the culture vessel. The main container includes a transparent portion through which the biological specimen in the main container can be externally observed. | 01-14-2010 |
| 20100028990 | STERILE BIOREACTOR BAG WITH INTEGRATED DRIVE UNIT - Flexible, sterilizable, disposable bioreactors are provided with integrated fluidic drive units that agitate media inside the bioreactor without introducing contamination. The bioreactor system ( | 02-04-2010 |
| 20100055773 | TISSUE PIECE PINCHING DEVICE AND CULTURE KIT - Under a state where the zipper | 03-04-2010 |
| 20100055774 | GAS PERMEABLE CELL CULTURE DEVICE AND METHOD OF USE - Gas permeable devices and methods are disclosed that provide more efficient cell culture. | 03-04-2010 |
| 20100086994 | Structure of fermentation apparatus - A fermentation apparatus includes a fermentation tank, an air-hole mesh board, a lift-up cover, a blender and a pressurization equipment. An opening is above fermentation tank, an oblique-board base is at the bottom of the fermentation tank, and a feed opening and an air outlet are on the fermentation tank. Two air inlet holes are on the oblique-board base to form a passage through the oblique-board base. Exhaustion holes are on a surface of the oblique-board base and interconnected with the passage. The air-hole mesh board is installed in the fermentation tank and between the feed opening and the oblique-board base. The lift-up cover is connected to the fermentation tank and disposed above the fermentation tank for covering the opening. The blender is between the lift-up cover and the air-hole mesh board. The pressurization equipment is connected to the air inlet hole for supplying a high-pressure gas into fermentation tank. | 04-08-2010 |
| 20100093073 | BIO-REACTOR - A bio-reactor for cultivating cells, comprising a culture vessel, at least one gas supply and/or liquid feed in addition to supply devices for gases and/or liquids enabling gases or liquids to be fed to the culture vessel. A mixture device, especially a Venturi nozzle is arranged between the supply device and gas supply or liquid feed in order to mix gas and/or liquid from the gas supply or liquid feed. | 04-15-2010 |
| 20100105130 | REACTION CONTAINER PLATE AND ITS REACTION PROCESSING EQUIPMENT - Intrusion of foreign matters from the outside of a reaction container plate and environmental contamination onto the outside are prevented. The reaction container plate ( | 04-29-2010 |
| 20100105131 | CIRCULATORY PACKED BED REACTOR - An improved circulatory packed bed reactor includes a fermentor, a ventilation system communicating with the fermentor through pipes, and a circulatory system. The fermentor has an upper pipe joint and a lower pipe joint. The circulatory system includes a pipe device and a cell-fixation device. The pipe device includes a circulating pipe outside the fermentor and circulating liquid pumps installed on the circulating pipe. The circulating pipe has one end connecting the upper pipe joint of the fermentor and communicating with the fermentor and another end connecting the lower pipe joint of the fermentor and communicating with the fermentor. The cell-fixation device is located in the fermentor. The cell-fixation device in the fermentor makes the cells in stationary state and submerge in the fermentation to perform deep submerged fermentation, which enhances the density of the fermented cells and cell's tolerance to toxicity, increases the output and the content of cell's secretions, and enables the cells re-utilization. | 04-29-2010 |
| 20100120134 | MICRO-ORGANISM PRODUCTION APPARATUS AND SYSTEM - A micro-organism production system having at least one micro-organism growth unit for maintaining therein micro-organisms in solution. Upon the receipt of a predetermined amount of live organisms, liquid and nutrients within the at least one micro-organism growth unit and the application of radiation thereto, the system produces the rapid growth of micro-organisms within the at least one micro-organism growth unit. | 05-13-2010 |
| 20100124779 | Two-Step Moulded Capillary - Reaction containers, such as plastic capillaries having an optimized volume-to-surface ratio that are suitable for real-time nucleic acid amplification (rtPCR) applications are disclosed as well as a method for the production of the reaction containers, in particularly the trtPCR plastic capillaries via a 2-step molding process. In the process, a capillary section is closed at one end, a tubular section is provided opened at both ends, and a linkage is provided between the capillary section and the tubular section, wherein the linkage is a fused joint designed to permanently link the open end of the capillary section to one of the open ends of the tubular section thus forming a reaction container having one opening, and in which the fused joint produces light scatter upon illumination. | 05-20-2010 |
| 20100144022 | Continuous Flow Bioreactor - The present invention is directed toward bioreactor systems capable of causing internal contents to have an angular motion throughout the bioreactor container without rotating the container. In one embodiment, the bioreactor system has a base platform, including three areas, a toroidal container removably attached to the base platform, a three separate members physically attached to the three areas, and a plurality of motors, where each of the motors is configured to cause an independent translational movement in each of the members and where the translation movement in each of the members causes a corresponding translational movement in a portion of the toroidal container proximate to the moving area. | 06-10-2010 |
| 20100151565 | CARTRIDGE FOR AUTOMATED MEDICAL DIAGNOSTICS - The present invention relates to a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a first component and a second component being connectable to each other, the first component comprising at least a first fluid opening and a first sealing surface and the second component comprising at least a second fluid opening and a second sealing surface. Upon connection of the first and second component the first and second fluid opening are placeable in fluid communication and the first and second sealing surfaces are placeable against each other to seal the fluid communication between the first and second fluid opening. The invention is characterized in that the cartridge comprises biasing means for biasing the second sealing surface in the direction of the first sealing surface. | 06-17-2010 |
| 20100159577 | AUTOMATIC CULTURE DEVICE, SLIDE VALVE, AND DISPOSABLE CONTAINER - A culture device includes: a housing accommodating therein a preservation container preserving a first solution liquid for cell culture, the housing having an opening for discharging the first solution liquid out of the housing; a cultivation container having an opening, in which the cell culture can be performed; and a slide valve provided between the housing and the cultivation container. The slide valve includes: a slide valve body; a connection hole formed in the slide valve body and capable of connecting the opening of the housing and the opening of the cultivation container; a first lid portion closing one open end of the connection hole; and a second lid portion closing the other open end of the connection hole. The first and second lid portion defines there-between a sealed space in the connection hole. The sealed space is capable of containing therein a second solution liquid for the cell culture. | 06-24-2010 |
| 20100203624 | THREE DIMENSIONAL DISPOSABLE BIOREACTOR - A bioreactor including a support, a container, means to secure the container on the support and nutrients and cell in the container. The container has top and bottom walls joined to form a chamber having a portion of the top and bottom walls joined by side walls; and end walls connected to the top and bottom walls forming a three dimensional container. The support is pivotally mounted to a base and driven about a single axis and the end walls of the container are transverse to the single axis. | 08-12-2010 |
| 20100221818 | Device for the extemporaneous preparation of active preparations - The invention relates to an autonomous portable device for the storage of at least two formulations and for the automatic extemporaneous preparation of an active solution from the two formulations, said device comprising: a first compartment for containment of a first formulation, a second compartment for containment of a second formulation, a retaining chamber which communicates at least with the first compartment by means of at least one transfer channel and which comprises at least one outlet channel for the active solution, manually triggered mixing and expelling means suitable for, after triggering, automatically: bringing the two formulations into contact, and expelling, via the outlet channel, at least a part of the active solution at the end of a minimum reaction time. | 09-02-2010 |
| 20100221819 | UPFLOW HYDROLYSIS REACTOR SYSTEM FOR HYDROLYZING CELLULOSE - A process for the enzymatic hydrolysis of cellulose to produce a hydrolysis product from a pre-treated cellulosic feedstock is provided. The process comprises introducing an aqueous slurry of the pre-treated cellulosic feedstock at the bottom of a hydrolysis reactor. Axial dispersion in the reactor is limited by avoiding mixing and maintaining an average slurry flow velocity of about 0.1 to about 20 feet per hour, such that the undissolved solids flow upward at a rate slower than that of the liquid. Cellulase enzymes are added to the aqueous slurry before or during the step of introducing. An aqueous stream comprising hydrolysis product and unhydrolyzed solids is removed from the hydrolysis reactor. Also provided are enzyme compositions which comprise cellulase enzymes and flocculents for use in the process. In addition, a kit comprising cellulase enzymes and flocculent is provided. | 09-02-2010 |
| 20100227387 | Structure and method for handling magnetic particles in biological assays - Magnetic handling structure ( | 09-09-2010 |
| 20100233795 | FERMENTATION VESSELS - A fermentation apparatus ( | 09-16-2010 |
| 20100233796 | FUEL CELL SYSTEM AND METHOD OF CONTROLLING SAME - A fuel cell system includes a fuel cell configured to generate electric power with a fuel gas and an oxygen gas fed to the fuel cell and to discharge exhaust gas including CO | 09-16-2010 |
| 20100255568 | CULTURING APPARATUS - A culturing apparatus has a culture vessel having a first elastic seal bonded on its upper surface and a culture space formed thereon, and a joint for supplying solution such as a medium to the culture vessel and a second elastic seal having microprojection formed at the lower face. The first elastic seal has a valve for supplying or discharging solution. The second elastic seal is formed with microprojection at the position corresponding to a valve for preventing a spill. The culture vessel and the joint are sucked between the first elastic seal and the second elastic seal, thereby forming an integral seeding device. | 10-07-2010 |
| 20100273250 | REACTION VESSEL, REACTION VESSEL LIQUID INTRODUCING DEVICE, LIQUID INTRODUCING AND REACTION MEASURING DEVICE, AND LIQUID INTRODUCING DEVICE - The invention relates to a reaction vessel, a reaction vessel liquid introducing device, a liquid introducing and reaction measuring device, and a liquid introducing device, and is directed to being able to perform temperature control of a liquid stored within the reaction vessel with a high accuracy and faithful responsiveness. The reaction vessel comprises: a storage chamber in which a liquid is storable, that has an opening part; a reaction chamber that is formed thinner or narrower than the storage chamber; and at least one flow passage that communicates between the storage chamber or the exterior and the reaction chamber. The reaction vessel is formed such that it is connectable to a liquid introducing section provided externally, and the liquid can be introduced into the reaction chamber by connecting to the liquid introducing section. | 10-28-2010 |
| 20100285574 | BIOMASS HYDROTHERMAL DECOMPOSITION APPARATUS AND METHOD - A biomass hydrothermal decomposition apparatus includes, a biomass feeder ( | 11-11-2010 |
| 20100285575 | BIOREACTOR - The invention relates to a bioreactor which comprises a closed housing with a housing wall and at least one chamber which is connected to the housing wall. The at least one chamber comprises a chamber inlet and outlet for respectively supplying and discharging material to and from the at least one chamber. The housing comprises a housing inlet for supplying material to the chamber inlet and a housing outlet for discharging treated material from the chamber outlet to the outside of the bioreactor. The bioreactor forms a closed volume in which a reactor pressure prevails in the bioreactor which is higher than the external pressure outside the bioreactor, in such a way that the bioreactor is self-supporting. | 11-11-2010 |
| 20100297748 | INTEGRATED FLUIDIC CIRCUITS - The invention generally relates to an integrated fluidic circuit. In certain embodiments, the circuit includes a main chamber having a withdrawal port, a carrier fluid occupying a volume in the chamber, in which the carrier fluid is immiscible with a sample fluid, and a plurality of liquid bridges disposed within the chamber. | 11-25-2010 |
| 20100297749 | METHODS AND SYSTEMS FOR BIOFUEL PRODUCTION - The present disclosure relates to methods and systems for biofuel production. Systems of integrated biorefineries (IBR) and methods of using IBRs for producing fuel compositions and other products are provided herein. The IBRs can use algae for generating biofeedstock to produce the fuel compositions. | 11-25-2010 |
| 20100323434 | Compartmentalized Nerve Culture System - The present invention relates generally to a compartmentalized nerve culture system. The compartmentalized nerve culture system has numerous applications including isolation of axons and cell bodies. The present invention has broad application for basic and pre-clinical research including, but not limited to, use in neuroscience, neuronal culture systems, co-culture systems, drug screening, morphological studies, and toxicology studies. | 12-23-2010 |
| 20100323435 | Injection System for Bio-fuel Reactor - The bio-fuel reactor injection system includes supplementing a biomass feedstock with a feedstock gas so that thermal conditions within the reactor body are optimized. The feedstock gas facilitates the flow of the feedstock through the feedstock injection system and maintains the feedstock below the feedstock's melting point until the feedstock is injected into the reactor body. In the preferred embodiment, the supplemental feedstock gas is nitrogen. The injection system also includes a plurality of screens that form a gas distributor plate. The gas distributor plate at least partially supports a fluidized bed within the reactor body. In the preferred embodiment, the nitrogen-supplemented feedstock is injected into the fluidized bed within the reactor. | 12-23-2010 |
| 20110003374 | BIOREACTOR - A bioreactor ( | 01-06-2011 |
| 20110014689 | Disposable Bio-Reactor System - A disposable bioreactor system with a focus on improving cell culture technology by introducing a disposable bioreactor bag which operates or functions in conjunction with a unique mechanism of external non-rotating gyrating motion that uses gravity in a natural way to make the fluid flow circumferentially in it. The bioreactor is eminently suitable to grow a variety of living cells and has the advantage of tangential flow to avoid clogging of filters. | 01-20-2011 |
| 20110027874 | Packed Bed for Nucleic Acid Capture and Amplification - A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation and annealing temperatures for PCR amplification. One embodiment provides an apparatus for DNA capture and amplification comprising a tubing or housing having a cavity, bed media in the cavity, and a heater operatively connected to the tubing or housing. | 02-03-2011 |
| 20110033918 | ROTATING BIOREACTOR - Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor. | 02-10-2011 |
| 20110111489 | SENSOR ADAPTER, METHOD FOR THE MANUFACTURE THEREOF, METHOD FOR THE USE OF A SENSOR IN THIS SENSOR ADAPTER AND BIOREACTOR WITH THIS SENSOR ADAPTER - A sensor adapter is described for the noninvasive positioning of a sensor, especially of an electrochemical sensor, in a medium. The sensor adapter comprises an accommodating channel, in which the sensor can be positioned and the one end region of which is closed off by a semipermeable membrane. Moreover, the sensor adapter comprises a hollow cylindrical sealing structure, which is disposed within the accommodating channel coaxially with the longitudinal axis of the latter and with which the sensor can be disposed gas tight adjacent to the semipermeable membrane. | 05-12-2011 |
| 20110129910 | COOLING DEVICE, AND ASSEMBLY, AND METHODS FOR LOWERING TEMPERATURE IN A CHEMICAL REACTION - Embodiments provide a cooling device. The cooling device comprises a container configured as a heat sink. The container is at least partially made from heat conducting material. The cooling device further comprises endothermic chemical material which is contained in the container. | 06-02-2011 |
| 20110129911 | Bioreactor Chamber - Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion. | 06-02-2011 |
| 20110136217 | Integrated Processes and Systems for Production of Biofuels Using Algae - A process for production of biofuels from biomass can include depolymerizing a biomass to form a feed. The feed can be formed by autotrophically growing algal biomass and extracting the feed therefrom. The algal feed can be converted to an algal oil by introducing the algal feed to an oil-producing algae under growth conditions sufficient to encourage formation of algal oil within the oil-producing algae. The algal oil can be extracted from the oil-producing algae and can further be converted to biodiesel. | 06-09-2011 |
| 20110151551 | BIOREACTORS - The present invention relates to improved single-use bioreactors comprising disposable plastic bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, and wherein the bioreactor bag is provided with a wrinkle preventing structure at each end of the clamping edges. The bag avoids formation of undesired wrinkles or creases which otherwise lead to fatigue of the plastic and eventually fracture. | 06-23-2011 |
| 20110151552 | BIOREACTORS - The present invention relates to improvements of bioreactor bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, wherein the top sheet is at least 5% longer than the bottom sheet between the clamping edges. The bioreactor bags provided by the invention avoid formation of undesired wrinkles or creases which otherwise may lead to fatigue of the plastic and eventually fracture. | 06-23-2011 |
| 20110159580 | METHOD FOR PREPARING PELLETS FROM RICE HUSK AND APPARATUS FOR REMOVING ODOR USING RICE HUSK PELLET BIO-MEDIA - A method for preparing pellets from rice husk includes: grinding rice husk; adding ammonia water to a mixture of ethylene vinyl acetate and poly(vinylacetate) to prepare a mixed liquid binder; mixing the mixed binder with the ground rice husk to obtain a binder/rice husk mixture; extruding the binder/rice husk mixture through an extruder; and cooling the extruded mixture at room temperature. | 06-30-2011 |
| 20110189764 | SINGLE USE DEVICE INCORPORATING A CONTAINER AND SCAFFOLD - The present invention relates to a single use device, alternatively called an assembly, that primarily comprises a single use container or bioreactor that incorporates a scaffold and is used in the growth, processing and/or preservation of cells, sterile fluid or related biopharmaceutical product and that may be at least partially sterilized by irradiation or exposure to ethylene oxide (ETO). | 08-04-2011 |
| 20110212513 | ISOLATOR FOR CELL CULTURE - An isolator for cultivating cells including a working chamber having a plurality of gloves arranged side by side into which operator's hands are inserted to operate cells, the working chamber being sectioned into at least an operation area for operating the cells, and an auxiliary working area for opening a packaged auxiliary instrument used to operate the cells, a gas supply unit that supplies gas into the working chamber so that the gas flows downwardly from an upper side in the working chamber, and a gas flow control unit for controlling the flow of the downwardly flowing gas so that the gas flows from the operation area to the auxiliary working area around the gloves, wherein the gas flow control unit has an exhaust hole portion that has an opened area for passing the gas therethrough and is provided at a lower portion of at least the auxiliary working area, and through which the gas in the auxiliary working area is exhausted. | 09-01-2011 |
| 20110212514 | METHOD AND APPARATUS FOR DISRUPTING CELLS AND AMPLIFYING NUCLEIC ACIDS USING GOLD NANORODS - Provided is a method of disrupting cells comprising adding gold nanorods to a solution containing cells and irradiating the gold nanorods with a laser to disrupt the cells. A method and an apparatus for continuously disrupting cells and amplifying nucleic acids in a single microchamber are also provided, wherein the method comprises introducing a solution containing cells and gold nanorods into a microchamber, irradiating a laser onto the gold nanorods to disrupt the cells, and amplifying a nucleic acid from the disrupted cells in the microchamber. | 09-01-2011 |
| 20110212515 | CULTURE/EXPOSURE DEVICE, IN PARTICULAR FOR CELL AND/OR BACTERIA CULTURES - In a culture/exposure device, in particular for cell and/or bacteria cultures, having receptacles ( | 09-01-2011 |
| 20110217764 | Rotating Bioreactor and Spool Harvester Apparatus for Biomass Production - An apparatus that exposes a biofilm growth surface to liquid media as it rotates. A biofilm growth substratum is wound around a rotatable body in the form of a non-rigid material capable of supporting biofilm growth. A harvester receives the biofilm laden substratum, collects the biofilm as a biomass and reloads the substratum onto the rotatable body. | 09-08-2011 |
| 20110229962 | TEMPERATURE-RESPONSIVE CELL CULTURE SUBSTRATE AND METHOD FOR PRODUCING THE SAME - A substrate having a pattern of two or more materials exhibiting different grafting efficiencies for a temperature-responsive polymer that varies its interaction with water in a temperature range of 0 to 80° C. by electron beam irradiation under the same conditions is grafted with the temperature-responsive polymer by simultaneously irradiating the surfaces of the materials with electron beams to obtain a temperature-responsive cell culture substrate. According to this method, a temperature-responsive cell culture substrate having a surface ( | 09-22-2011 |
| 20110229963 | STIRRER FOR A BIOREACTOR - A stirrer for a bioreactor has first and second opposed mountings fastened to the inner surfaces of opposite walls of the bioreactor and disposed along a common rotational axis. A first arm has an end connected to the first mounting for rotation about the rotational axis and for pivoting about a first pivot axis that is transverse to the rotational axis. A second arm has an end connected to the second mounting for rotation about the rotational axis and for pivoting about a second pivot axis that is transverse to the rotational axis. Ends of the arms are coupled for pivoting about at least one additional pivot axis that is transverse to the rotational axis. | 09-22-2011 |
| 20110269223 | CORROSION INHIBITION - The present invention relates to a methods, products and uses for inhibiting corrosion. A provided method comprises the steps of: a) subjecting cellulosic biomass to hydrolysis to obtain a hydrolysate liquid; b) optionally, subjecting the hydrolysate liquid from step a) to one or more of the steps of further hydrolysis, fermentation and/or distillation; and c) using the hydrolysate liquid from step a) or b) to inhibit corrosion. | 11-03-2011 |
| 20110287531 | Microalgae Growth Pond Design - A raceway pond for circulating microalgae in a fluid medium includes a plurality of interconnected channels. Each channel is straight and has a structured gradient, due to tilt or terracing, that moves the fluid medium along the raceway. In operation, the concentration of microalgae in the fluid medium is maintained substantially constant, and the depth of the fluid medium in the raceway is maintained below a pre-determined level. | 11-24-2011 |
| 20110300623 | PROCESS FOR ACCELERATED CAPTURE OF CARBON DIOXIDE - The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed. | 12-08-2011 |
| 20110312080 | POROUS FILMS BY A TEMPLATING CO-ASSEMBLY PROCESS - A method of making a composite includes providing a particle suspension comprising colloidal particles ( | 12-22-2011 |
| 20110312081 | REAGENT DISPENSING APPARATUS FOR ARRAY OF MICROFLUIDIC DEVICES - A reagent dispensing apparatus for loading reagents into a fixed array of microfluidic devices, each microfluidic device having a digital memory for data related to the reagents loaded into the microfluidic device, the reagent dispensing apparatus having a plurality of reagent vials each of the vials having an integrated circuit with memory storing data regarding the reagent in the vial, and a droplet dispenser, a mounting surface for detachably mounting the fixed array of microfluidic devices for movement relative to the vials, and, a control processor for operative control of the vials and the mounting surface, wherein, the control processor is configured to activate the droplet dispenser of the vial selected, move the vial into registration within one or more of the microfluidic devices within the fixed array and download the data from the integrated circuit to the digital memory of the one or more microfluidic devices. | 12-22-2011 |
| 20110312082 | DISPENSING APPARATUS FOR WAFER-SCALE DISPENSING OF REAGENTS - A reagent dispensing apparatus for loading reagents into a silicon wafer on which an array of lab-on-a-chip (LOC) devices are fabricated, each LOC device having a digital memory for data related to the reagents loaded into the LOC device, the reagent dispensing apparatus having a plurality of reagent vials each of the vials having an integrated circuit with memory storing data regarding the reagent in the vial, and a droplet dispenser, a mounting surface for detachably mounting the silicon wafer for movement relative to the vials, and, a control processor for operative control of the vials and the mounting surface, wherein, the control processor is configured to activate the droplet dispenser of the vial selected, move the vial into registration within one or more of the LOC devices on the silicon wafer and download the data from the integrated circuit to the digital memory of the one or more LOC devices. | 12-22-2011 |
| 20120003732 | MICROFLUIDIC CELL CULTURE SYSTEMS - A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. | 01-05-2012 |
| 20120003733 | MIXING CONTAINER COMPRISING A SHAFT BEARING IN THE UPPER PART - A mixing container includes a flexible container, mixing elements and an upper bearing having a rigid flange. The flange is provided with an insertion passage that fluidically communicates with the inside space on one end and with the outside of the container on the other end. The flange is fixed in a rigid and sealing manner to the upper part of the wall of the container around an insertion opening, the insertion passage and the insertion opening communicating fluidically. The flange also supports, on the inside thereof, an upper bearing that is arranged inside, adjacent to the insertion passage, without preventing the fluidic communication between the insertion passage and the insertion opening. The mixing container is used to receive a biopharmaceutical content to be mixed. | 01-05-2012 |
| 20120021503 | BIOMASS HYDROTHERMAL DECOMPOSITION APPARATUS, TEMPERATURE CONTROL METHOD THEREOF, AND ORGANIC RAW MATERIAL PRODUCTION SYSTEM USING BIOMASS MATERIAL - A biomass hydrothermal decomposition apparatus that feeds a solid biomass material | 01-26-2012 |
| 20120028345 | SOLID STATE FERMENTATION (SSF) SYSTEM - The present invention relates to a solid state fermentation system. The system comprises a fermenter module having plural port means for allowing inlet and outlet of substrate to be fermented and control module being operatively inter-engaged with said fermenter module in a manner so as to provide control of fermentation parameters. | 02-02-2012 |
| 20120034688 | True nucleic acid amplification - A system and method directed to DNA amplification with optional in situ purification, sequencing and/or detection, or a system compatible with integrated, post-amplification purification and or sequencing by capillary electrophoresis and other methods. The device is a single, helical channel formed of fused silica with heat zones defined about fixed arcs of the helix inner and/or outer circumference. The length of the helical channel and the cycle number and dwell time may be varied by altering the pitch of the helix within the cylindrical substrate. In another embodiment, the heat zone arcs lengths are also variable. In still another embodiment, multiple helical channels are available in parallel within the same structure. Separation channels may be integrated on the device for post-amplification purification and/or sequencing. One or more detection schemes may be provided on the device or seamlessly integrated with the device, for monitoring amplification and/or detecting specific products. | 02-09-2012 |
| 20120040448 | Microreactors With Connectors Sealed Thereon; Their Manufacturing - The present invention deals with microfluidic devices ( | 02-16-2012 |
| 20120058550 | BIOREACTORS COMPRISING FUNGAL STRAINS - Disclosed herein are compositions comprising an isolated cellulose degrading fungus. Also disclosed are culture compositions and bioreactor compositions comprising the cellulose degrading fungus. Further described herein are filtration and extraction devices comprising the cellulose degrading fungus. Still further disclosed are bioprocessing facilities for and methods for producing co-products resulting from one or more bioprocesses of the cellulose degrading fungus. | 03-08-2012 |
| 20120064617 | SYSTEM AND METHOD FOR CONTINUOUS FERMENTATION OF ALGAE - The present invention is a method for fermentation of algae or algaefaction method. The method includes feeding a hydrocarbon composition into a gasifier and pre-heating a biomass stream from a fermentation reactor. The biomass stream includes a liquid portion, a catalyst, and a biomass solids portion ranging between 15-92% by weight of the biomass stream. The biomass solids portion is algae or algal solids. The biomass stream is pre-heated to a temperature range between 200° F. and 500° F. Both the syngas and the pre-heated biomass stream are injected as a mixture into a reactor, where the mixture is separated into a gas component, liquid component, and solids component. The solids component is algal crude, which can be collected for processing as transportation fuels. The gas component is a lower temperature syngas, which can also be collected for processing as electricity or transportation fuels. | 03-15-2012 |
| 20120070887 | Cell Visualization System for Multi-Layer Cell Culture Device - The present invention relates generally to a multi-layer system for containing cells in culture, and a system for visualizing cells cultured in the multi-layered system. More specifically, the present invention relates to a multi-layer cell culture device having a specialized bottom plate and a microscope adaptor which can accommodate a microscope to allow microscopic visualization of cells cultured in the device. | 03-22-2012 |
| 20120070888 | Horizontal Array Bioreactor for Conversion of Syngas Components to Liquid Products - A membrane supported bioreactor arrangement and method for anaerobic conversion of gas into liquid products including membrane modules having hollow fibers, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for retaining a porous biolayer about the outer surface of the membrane wall and a less permeable hydration layer around the hollow fiber lumen; a membrane vessel for retaining the membrane modules in a process gas for formation of the biolayer on the outer surface of the hollow fiber wall by interaction of microorganisms with a process gas and for the production of a liquid product, wherein the membrane vessel retains the membrane modules in a common horizontal plane; provides a seal between contents of the membrane tank and ambient atmosphere; and includes a liquid supply conduit for communicating the process liquid with the hollow fiber lumens of the hollow fibers. | 03-22-2012 |
| 20120077262 | LIQUID REFLUX HIGH-SPEED GENE AMPLIFICATION DEVICE - The present invention provides a liquid reflux reaction control device comprising:
| 03-29-2012 |
| 20120083029 | ROTATING CULTURE VESSEL AND AUTOMATIC CELL CULTURE APPARATUS USING SAME - Disclosed is a rotating culture vessel based on a rotating culture technology using an RWV, by which cell seeding, liquid medium exchange, quality control and so on can be automated and degassing can be conducted simultaneously with liquid medium exchange without disturbing the cells under culture. Also disclosed is an automatic cell culture apparatus using the same. A rotating culture vessel, which contains cells and a liquid culture medium, to be attached to a horizontal rotating shaft of a rotating culture device to three-dimensionally culture the cells, wherein one or more inlets/outlets for supplying cells and a liquid culture medium at the early stage and then taking out the cultured cells, are formed at appropriate position of a flat cylindrical culture container; at least one pair of a supply port and a discharge port for liquid medium exchange is provided on the outer circumferential cylindrical face of the culture container. | 04-05-2012 |
| 20120100602 | BIOREACTOR SYSTEM FOR MECHANICAL STIMULATION OF BIOLOGICAL SAMPLES - The subject application provides an apparatus for applying mechanical loading to a biological sample, said apparatus comprising: a bioreactor device configured to house the biological sample, and a load application unit for applying mechanical loading to the biological sample housed in the bioreactor device, said load application unit including: a) a first sliding arm for applying mechanical displacement to the biological sample in the bioreactor device in a first predetermined direction; and b) a guide rail coupled to the first sliding arm to limit movement of the first sliding arm such that the first sliding arm moves only in the first predetermined direction when displaced. | 04-26-2012 |
| 20120129249 | STIRRING APPARATUS FOR STIRRING MICROORGANISMS IN A CULTURING MEDIUM - The invention provides a stirring apparatus for stirring microorganisms such as, an alga in a culturing medium. The stirring apparatus includes one or more supporting structures. The stirring apparatus further includes a plurality of paddle units operatively connected to the one or more supporting structures. The plurality of paddle units are submerged in the culturing medium holding the microorganisms. Further, the plurality of paddle units are configured to rotate for stirring the microorganisms in the culturing medium. In response to the rotation of the plurality of paddle units, the stirring apparatus propels in the culturing medium. | 05-24-2012 |
| 20120142087 | REACTOR FOR THE ANAEROBIC DIGESTION OF BIOMASS - A reactor for the anaerobic digestion of biomass, includes: a gas-tight tank that is accessible by a sealed door designed for the intake of the biomass, the tank being designed in the form of a garage; equipment for heating the biomass provided e.g. at the walls of the tank; a biogas-tapping connection; and equipment for draining the seepage liquid. According to the invention, the lower walls ( | 06-07-2012 |
| 20120156767 | PCR DEVICE - PCR device ( | 06-21-2012 |
| 20120156768 | PRESSURE AND CIRCULATION CULTURE APPARATUS AND PRESSURE AND CIRCULATION CULTURE SYSTEM - The pressure and circulation culture apparatus includes a holder (culture chamber part), a pressure transmission part and a culture solution circulation line (culture circuit). The holder is a means that reserves culture solution and that holds a cultured object. The pressure transmission part is a means that communicates with the holder and transmits an external pressure to the culture solution. The culture solution circulation line is a means that is connected to the holder via the pressure transmission part, and circulates the culture solution through the holder via the pressure transmission part. Such a structure is included, and an external pressure is made to operate on the culture solution via the pressure transmission part to allow pressure on the cultured object in the holder and circulation of the culture solution in the holder. | 06-21-2012 |
| 20120164720 | BIOGAS PLANT AND SERVICE DEVICE FOR A BIOGAS PLANT - A biogas plant and a servicing device for a biogas plant having a servicing unit and a servicing section, the biogas plant includes a fermenter tank with a fermentation section and a gas section at an interior space of the fermenter tank. The fermenter tank is closed gas-tight by a gas closing wall disposed at the fermenter tank. The servicing unit is provided with a movable sealing device having at least one retention wall of a flexible material and when installed as intended can be moved between an inoperative position and a sealing position. The sealing device is suitable to separate the servicing section substantially gas-tight from the gas section in the sealing position. | 06-28-2012 |
| 20120164721 | CELL CULTURE APPARATUS - A cell culture apparatus has four sections, including a cell culture chamber, refrigerator, control unit, and intermediate chamber. The cell culture chamber includes a culture vessel base as a holding member for holding and installing a culture vessel, a microscope for photographing a cell image within the culture vessel, and a drive base which has drive mechanisms such as a pump and a valve to be connected to a flow channel having a closed structure including a tank. With the drive base within the cell culture chamber as the center, the rotatable culture vessel is arranged in the horizontal direction and the refrigerator in which the culture medium base containing the cell fluid and culture medium is installed is arranged in the vertical direction. The arrangement configuration is space-saving and provides a short distance between the instruments. | 06-28-2012 |
| 20120178153 | pH SENSOR INTEGRATION TO SINGLE USE BIOREACTOR/MIXER - A pH sensing bioreaction system is provided. The system includes a bioreaction container having a plastic wall and a pH sensor attached to the plastic wall. The pH sensor includes a sensor body having a flange that is sealingly attached to the plastic wall. The sensor body has a reference electrolyte therein and a first sensing element disposed in the reference electrolyte. The first sensing element is configured to contact both the reference electrolyte and a sample solution inside the bioreaction container. A second sensing element is positionable into an interior of the bioreaction container. The pH sensor has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container, and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container. | 07-12-2012 |
| 20120178154 | ORGANIC MATERIAL PRODUCTION SYSTEM USING BIOMASS MATERIAL AND METHOD - An organic material production system using biomass material includes: a hydrothermal decomposition apparatus that causes the biomass material and hot compressed water to countercurrently contact with each other and undergo hydrothermal decomposition, so as to separate the lignin component and the hemicellulose component from a biomass solid residue; a cellulose enzymatic saccharification device that treats, cellulose in the biomass solid residue, so as to enzymatically saccharify the cellulose to a first sugar solution containing hexose; an alcohol fermenter that produces alcohols by fermentation using the obtained first sugar solution; a sulfuric acid decomposition device that decomposes the hemicellulose component in hot water discharged from the hydrothermal decomposition apparatus, which contains the eluted lignin component and the eluted hemicellulose component, so as to decompose the hemicellulose component to a second sugar solution containing pentose; and a second alcohol fermenter that produces, using the second sugar solution containing pentose, alcohols by fermentation. | 07-12-2012 |
| 20120178155 | ROTATING CELL SEEDING MODULE - An apparatus and method is described for seeding cells on a sample or specimen. The cells may be selectively and locally seeded on an upper and lower surface of a planar sample or specimen or on either or both of an interior luminal surface and exterior surface of a hollow sample or specimen. The apparatus includes a chamber suitable for cell seeding, cell growth, and cell conditioning. | 07-12-2012 |
| 20120184026 | INTEGRATED PROCESSING PLANTS - An integrated plant comprising: (a) one or more lignocellulose processing units producing one or more sugar streams and one or more lignin streams; (b) one or more lignin-processing units processing one or more of said lignin streams into a lignin product; and (c) one or more sugar processing units processing one or more of said sugar streams into a sugar product; (d) at least one transfer mechanism transferring one or more of said sugar stream(s) to one or more of said sugar processing units over a distance of 5 km or less; and (e) at least one transfer mechanism transferring said lignin stream from one or more of said lignocellulose processing units to one or more of said lignin processing units over a distance of 5 km or less. | 07-19-2012 |
| 20120202279 | ONSITE INTEGRATED PRODUCTION FACTORY - An onsite integrated production factory having an electrolytic plant, an ethanol plant, a vegetable plant, a culturing plant, and a power generation unit. The onsite integrated production facility is arranged so that fresh water, sulfuric acid or caustic soda produced by and received from the electrolytic plant is used in the ethanol plant to produce and output oxalic acid, sodium oxalate, fuel bioethanol. The oxalic acid or sodium oxalate produced in and received from the ethanol plant is used for removing calcium contained in the sea water in the electrolytic plant. The vegetable plant produces vegetables for generation and outputting of oxygen by receiving the carbon dioxide generated during the fermentation process in the ethanol plant and fresh water from the electrolytic plant. The culturing plant has a fishery farm or reef for using the oxygen generated in the vegetable plant. | 08-09-2012 |
| 20120208265 | 3D MICROSTRUCTURING FOR GENERATING MIXED STRUCTURES AND CHANNEL STRUCTURES IN MULTILAYER TECHNOLOGY FOR USE IN OR FOR THE CONSTRUCTION OF REACTORS - The present invention relates to a channel structure for a bioreactor, biochemical reactor, chemical reactor or a reformer comprising a plurality of individual layers stacked on one another and having a respective plurality of openings which pass completely through the respective individual layer and which are characterized in that at least two directly adjacent individual layers each have at least one layer section whose openings are arranged in the form of a pattern respectively regular in two dimensions and in that at least two of the layer sections provided with such a pattern in this manner of directly adjacent individual layers overlap at least in part, wherein the openings of the two at least partly overlapping layer sections are rotated and/or offset with respect to one another in the overlap region. | 08-16-2012 |
| 20120214226 | INSERT FOR CELL CULTURES - An insert for cell cultures has a hollow housing ( | 08-23-2012 |
| 20120220024 | REACTION VESSEL - A reaction vessel assembly for use with thermal cyclers is described. The assembly includes a reaction vessel and a casing defining a cavity. In a first configuration, the casing receives the reaction vessel within the cavity, to act as a protective casing for the reaction vessel. In a second configuration, the casing engages with a mouth of the reaction vessel, to close the vessel. In this configuration, the casing may also act as a handle. In preferred embodiments, the reaction vessel is in the form of a capillary tube, and/or may include an integrated collimating lens. Certain embodiments also include an RFID tag. | 08-30-2012 |
| 20120220025 | PROCESS FOR ACCELERATED CAPTURE OF CARBON DIOXIDE - The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed. | 08-30-2012 |
| 20120220026 | GAS TEMPERATURE/HUMIDITY REGULATION METHOD AND GAS SUPPLY DEVICE - When a gas containing an amount of water vapor equivalent to that contained in the gas at the desired temperature Td and the desired relative humidity Hd is assumed, and the temperature of the gas when its relative humidity is 100% is defined as an intermediate target temperature Tc, Tc can be calculated from Td and Hd. The gas is mixed with water vapor to increase the temperature of the gas to the intermediate target temperature Tc while increasing the relative humidity of the gas to 100%. The gas heated to the intermediate target temperature Tc is heated to the desired temperature Td while maintaining the amount of water vapor contained therein so as to regulate the relative humidity of the gas to the desired relative humidity Hd. Gas maintained at the desired temperature and the desired humidity can thus be stably supplied. | 08-30-2012 |
| 20120225476 | SYSTEMS FOR THE UTILIZATION OF RUMINANT ANIMAL METHANE EMISSIONS - A process for the utilization of the methane produced by enteric fermentation, specifically to a process that utilizes methane produced by ruminant animals through enteric fermentation as a source of carbon and/or energy for the directed production of methane-based goods or processes is provided. | 09-06-2012 |
| 20120238010 | AUTOMATED BIOLOGICAL GROWTH AND DISPENSING APPARATUS - An automated biological growth and dispensing apparatus utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for agitation may be integral and removable with the growing tank or may be adapted for a quick connection and disconnection with the growing tank. The growing tank may be disposable and each new growing tank may be provided as a sealed container including a starting amount of a biomass and/or nutrient. | 09-20-2012 |
| 20120258526 | PACKING MATERIAL COMPRISING STARCH-MODIFIED POLYURETHANE FOR THE BIOFILTRATION OF ORGANIC COMPOUNDS PRESENT IN GASEOUS OR LIQUID EFFLUENTS, PRODUCTION METHODS THEREOF AND BIOFILTRATION SYSTEM - The invention relates to a packing material for biofilters, having a polyurethane polymer and starch. The packing material is resistant to compaction, can sorb pollutant organic compounds and reduces the start-up time of the biofilter. The packing material can be used as a substrate in the biofiltration of volatile and/or semi-volatile organic compounds present in gaseous or liquid effluents. | 10-11-2012 |
| 20120270307 | BIOGAS DESULFURIZATION DEVICE - A biogas desulfurization device comprises an anaerobic system, a desulfurization liquid circulating system, an oxygen supply device and a desulfurization system, wherein the anaerobic system is used for generating biogas and filling the generated biogas into the desulfurization system, the desulfurization liquid circulating system is used for filling the desulfurization liquid into the desulfurization system and recycling the desulfurization liquid that has undergone the desulfurization operation, the oxygen supply device is used for filling air into the desulfurization system, and the desulfurization system which comprises at least one stage desulfurization tower group is used for carrying out the desulfurization operation on the biogas from the anaerobic system, the desulfurization operation is conducted by the desulfurization liquid received from the desulfurization liquid circulating system in an aerobic environment. The biogas desulfurization device can reduce the amount of hydrogen sulfide in the biogas to less than 10 ppm while eliminating secondary pollution. | 10-25-2012 |
| 20120270308 | Pressing Arrangement for a Cover, in Particular in a Laboratory Apparatus, and Method for Pressuring by Using a Pressing Arrangement - The invention relates to a pressing arrangement for a cover, in particular in a laboratory thermostat, having at least: a first component disposed to exert an excitation force, a second component, in particular a plate component disposed to exert a pressing force Fz in at least one target position, a transmission device disposed for transmitting force from the first component to the second component, characterized in that the transmission device comprises a transmission component disposed to be driven by the first component and to drive the second component, and the transmission device comprises at least one elastic tensioning member disposed to be driven by the first component so as to change its tension and to drive the transmission component, and the transmission device or the transmission component causes the setting of the pressing force Fz in dependence on the target position. The invention further relates to a corresponding method for pressuring. | 10-25-2012 |
| 20120276622 | APPARATUS AND METHOD FOR HIGH-THROUGHPUT MICRO-CELL CULTURE WITH MECHANICAL STIMULATION - A method and apparatus for high-throughput micro-cell culture with mechanical stimulation is disclosed. In one embodiment, the apparatus includes a cell culture vessel and a fluid pressure supply unit. The cell culture vessel has a membrane, a culture medium chamber, and a pressure chamber; and the fluid pressure supply unit that has a fluid pressure supply device and a control device is connected fluidly to the pressure chamber. When the fluid pressure in the pressure chamber changes, the membrane vibrates accordingly to generate a mechanical stimulation to the cultured cells in a controllable manner. In another embodiment, the control device can be an electro-magnetic valve. | 11-01-2012 |
| 20120288927 | BIOMASS TREATMENT DEVICE - A biomass treatment device (A) includes a hot compressed water reaction device ( | 11-15-2012 |
| 20120295342 | PREVENTION OF CONTAMINATION OF FEED RESERVOIRS & FEED LINES IN BIOREACTOR SYSTEMS - A method to prevent contamination of feed line(s) and nutrient feed reservoir(s) is disclosed. In this method a heated zone is established in the feed line close to the location where the feed line connects to the bioreactor. The heated zone prevents back growth of cells from the bioreactor back into the feed line and further into the feed reservoir. | 11-22-2012 |
| 20120295343 | CLOSURE ASSEMBLY FOR CELL CULTURE APPARATUS - A closure assembly for a cell culture apparatus includes a port and a snap cap. The port has an annular sidewall defining an opening in communication with a cell culture chamber of a cell culture apparatus. The sidewall has (i) external threads for cooperating with internal threads of a twist cap and (ii) an annularly protruding snap cap engagement feature. The snap cap has a top and an annular sidewall extending from the top. The sidewall of the snap cap has an inwardly annularly projecting element configured to engage with the annularly protruding snap cap engagement feature of the port such that, when fully engaged, the snap cap is not readily removed from the port by unaided human force. | 11-22-2012 |
| 20120301954 | SENSOR ATTACHMENT ARRANGEMENT FOR FLEXIBLE BAGS - An attachment arrangement for providing a sensor in a flexible bag, said attachment arrangement comprising:
| 11-29-2012 |
| 20120309082 | MICRO-FLUID SUPPLYING DEVICE HAVING GAS BUBBLE TRAPPING FUNCTION - A micro-fluid supplying device having a gas bubble trapping function. The micro-fluid supplying device includes: a fluid supplier including a fluid having a biomaterial; a trap chamber in which a gas bubble is removed from the fluid supplied from the fluid supplier; and a fluid discharger which externally discharges a material supplied from the trap chamber. Material properties of a side wall and a bottom of an inside of the trap chamber are different from each other. The side wall has a better property of wetting with respect to the fluid supplied from the fluid supplier than the bottom. | 12-06-2012 |
| 20120322140 | Non-Contact Radiant Heating and Temperature Sensing Device for a Chemical Reaction Chamber - An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber without direct physical contact between a heating device and the reaction chamber, or between a temperature sensor and the reaction chamber. A plurality of chemical reaction chambers can simultaneously or sequentially be heated independently and monitored separately. | 12-20-2012 |
| 20120322141 | Reaction chip, reaction method, temperature controlling unit for gene treating apparatus and gene treating apparatus - The reaction chip of the present invention has a plurality of recesses | 12-20-2012 |
| 20120329146 | Lignin-Solvent Fuel and Method and Apparatus for Making Same - The present invention is a process and apparatus for forming various bio-products from cellulosic plant material. The plant material is subjected to a pulping step in which lignin is extracted from the material by an aqueous lignin solvent to form a lignin-solvent mixture and purified cellulose. The lignin-solvent mixture can be separated from the water to form a high energy density fuel that can be used independently or combined with biodiesel. The purified cellulose can be used in conventional processes, e.g., paper making, or can be converted to fermentable sugars with a cellulase enzyme to produce other bio-products depending on the operating conditions of the fermenter. The bio-products produced by the fermenter can include the solvent that may be recycled for use in extracting the lignin. | 12-27-2012 |
| 20130034898 | CONTINUOUS CULTURING DEVICE - A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas. The device is particularly useful for culturing bone cells for dental implants or bone reconstruction. | 02-07-2013 |
| 20130045530 | SELF-FOLDING SUB-CENTIMETER STRUCTURES - A sub-centimeter structure includes a first structural component, a second structural component arranged proximate the first structural component, and a joint connecting the first and second structural components. The joint includes a material that has a first phase that is substantially rigid to hold the first and second structural components in a substantially rigid configuration while the material is in the first phase. The material of the joint has a second phase such that the joint is at least partially fluid to allow the first and second structural components to move relative to each other while the material is in the second phase. The joint interacts with the first and second structural components while the material is in the second phase to cause the first and second structural components to move relative to each other. And, the first and second structural components include a polymer. | 02-21-2013 |
| 20130052724 | Ethanol and Protein Feed Plant Production System Using Whey Permeate - The present invention is a system for producing ethanol and yeast protein feed by fermenting whey permeate, a dairy waste product using four types of tanks: an inoculation tank, a seeding tank, a propagation tank, and a fermentation tank. Whey permeate and various chemicals are added to each of the tanks before being heated. The fermentation process for producing ethanol and yeast protein feed from whey permeate lasts 24 hours. | 02-28-2013 |
| 20130052725 | SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS - A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 10 | 02-28-2013 |
| 20130071916 | SYNTHETIC COATING FOR CELL CULTURE - A method for coating a surface of a cell culture article includes dissolving a polymer having a covalently attached polypeptide in an aqueous solution to produce a polymer solution. The polymer is formed from monomers selected to form a polymer having a linear backbone, wherein the polymer is crosslink free. The weight percentage of the polypeptide relative to the polymer conjugated to the polypeptide is sufficiently high to render the polymer conjugated to the polypeptide water soluble. The aqueous solution is substantially free of organic solvents. The method further includes (i) disposing the polymer solution on the surface of the cell culture article to produce a coated article; and (ii) subjecting the coated article to sufficient heat or electromagnetic radiation to attach the polymer conjugated to a polypeptide to the surface of the cell culture article. | 03-21-2013 |
| 20130078712 | Nucleic Acid Amplifier and Nucleic Acid Inspection Device Employing the Same - A nucleic acid amplifier comprises a holder | 03-28-2013 |
| 20130084631 | REAGENT RESERVOIR SYSTEM FOR ANALYTICAL INSTRUMENTS - The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation. | 04-04-2013 |
| 20130089923 | DEVICE FOR RAPIDLY DETECTING MICROORGANISMS - The disclosure includes: a coating composition, comprising a powdered cold-water-soluble gelling agent and surface-modified nanoparticles disposed in the powdered cold-water-soluble gelling agent; a coated film that includes a transparent film coated with the coating composition; and a device for growing microorganisms, including the coated film releasably attached to at least a portion of a body member that includes a self-supporting and water-proof substrate. | 04-11-2013 |
| 20130102068 | CULTURE APPARATUS AND METHOD OF REPLACING CULTURE MEDIUM - There is provided a culture apparatus including: a first pipe having a discharge channel formed at one end thereof; a second pipe having a suction channel formed at one end thereof; and a connection channel connecting the first and second pipes. | 04-25-2013 |
| 20130115687 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA - The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample. | 05-09-2013 |
| 20130122579 | FERMENTER FOR A BIOGAS PLANT - A fermenter for a biogas plant which operates with wet fermentation includes a fixed casing which surrounds a reaction space, an inlet for biomass and an outlet for the fermentation reside. A wall is arranged inside the casing, which separates the inlet from the outlet. | 05-16-2013 |
| 20130122580 | CULTURE VESSEL FOR FORMING AGGREGATED CELL MASS - The present invention provides a culture vessel for forming an aggregated cell mass which has at least two wells, wherein the wells are made from a light-shielding member and an inner surface of the wells is subjected to treatment to impart cellular non-adhesiveness. | 05-16-2013 |
| 20130130369 | SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS - Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples. | 05-23-2013 |
| 20130137168 | BIOCHIP - There is provided a biochip including a first substrate having a plurality of biological materials disposed thereon at predetermined intervals; first coupling units respectively extending from both ends of the first substrate and rotatably connected to the first substrate; and a second substrate including first groove portions formed in both ends thereof, the first coupling units being respectively inserted into the first groove portions. | 05-30-2013 |
| 20130137169 | MICROCHIP AND METHOD OF PRODUCING THE SAME - Provided is a microchip including a plurality of substrates, a reaction zone configured to function as a reaction site of a reaction, and a circumferential path on a circumferential part of the reaction zone with an inside of the circumferential path being at a pressure negative to atmospheric pressure, in which the circumferential path is disposed on at least one side of at least one of the substrates bonded together. | 05-30-2013 |
| 20130137170 | Multi-Tube Biofilter System for Treating Waste Gas - Disclosed is a multi-tube biofilter system for treating waste gas. The multi-tube biofilter system includes a multi-tube biofilter and a nutrient solution supply system. The multi-tube biofilter includes an outer casing, at least two reticulated tubes disposed in the outer casing, a packing medium portion, and a nutrient solution spraying system. The outer casing is opened to define a gas inlet, a gas outlet, and a water outlet therein. The packing medium portion is attached to an outer surface of each of the reticulated tubes, wherein a liquid entering end of the nutrient solution spraying system is in communication with the nutrient solution supply system via a pipeline, and solution spraying ends of the nutrient solution spraying system face the reticulated tubes. | 05-30-2013 |
| 20130143313 | SEPARATIVE HARVESTING DEVICE - A harvesting device for capturing a biological product directly by binding the secreted biological product with a resin, discarding the nutrient medium and eluting the biological product as a concentrated solution, eliminating the steps of sterile filtration and volume reduction, thus allowing one to combine the steps of recombinant expression and separation of a biological product. The method allows loading of resin for column-purification, eliminating all steps of perfusion process and maintaining a sink condition of a toxic product in nutrient medium to optimize productivity of host cells. The instant invention also allows harvesting of solubilized inclusion bodies after the cells have been lysed and refolding of proteins inside the bioreactor. | 06-06-2013 |
| 20130164831 | MULTILAYER FILM AND CELL CULTURE CONTAINER - Provided are a multilayer film having excellent gas permeability and excellent handling properties and hence is suited for forming a cell culture container, and a cell culture container formed by using the same. | 06-27-2013 |
| 20130171724 | CHEMICAL REACTION VESSELS - Chemical reaction vessels are disclosed herein. An example method includes forming a reaction chamber between two pliable sheets and dividing the reaction chamber into a plurality of chambers. The reaction chamber is to have a substantially planar base, and the reaction chamber is to hold a fluid for a chemical reaction. | 07-04-2013 |
| 20130189771 | CELL CULTURE DEVICE - A cell culture device has a chamber bottom, a wall section and a lid that enclose a culture chamber. A first electrode in the chamber bottom extends over a cell culture area of the culture chamber onto which cells are to be cultured. A second electrode in the lid is aligned with the first electrode and extends over an area in the lid corresponding to the cell culture area. A stimulation pulse generator applies stimulation pulses over the electrodes to form an electric field with a homogenous current density in the cell culture area. | 07-25-2013 |
| 20130196422 | SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS - Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples. | 08-01-2013 |
| 20130210131 | FILTER DEVICE FOR FACILITATING CHARACTERIZING BEHAVIOR OF CELLS - A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well. | 08-15-2013 |
| 20130230914 | CULTURE CONTAINER FOR ADHERENT CELLS AND METHOD FOR PRODUCING CULTURE CONTAINER FOR ADHERENT CELLS - A culture bag for culturing adherent cells is provided without requiring a highly clean production environment and a complex production step such as a masking step. An adherent cell culture vessel that is formed of a polyolefin is configured so that part or the entirety of the inner surface of the culture vessel has a static water contact angle of 95° or more, and has an advancing contact angle and a receding contact angle that satisfy the inequality “advancing contact angle−receding contact angle>25°” when water runs down along the inner surface. | 09-05-2013 |
| 20130252323 | MIXING DEVICE FOR CREATING AN OUTPUT MIXTURE BY MIXING A FIRST MATERIAL AND A SECOND MATERIAL - A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber. | 09-26-2013 |
| 20130260449 | THERMAL CYCLER AND CONTROL METHOD OF THERMAL CYCLER - A thermal cycler includes an attachment unit having an insertion opening for insertion of a reaction container including a channel filled with a reaction solution containing reverse transcriptase enzyme and a liquid having a lower specific gravity than that of the reaction solution and being immiscible with the reaction solution, a first heating unit that heats a first region of the channel, a second heating unit that heats a second region of the channel nearer the insertion opening than the first region, a drive mechanism that switches arrangement of the attachment unit, the first heating unit, and the second heating unit between a first arrangement and a second arrangement, and the control unit performs the first heating unit to be a temperature at which reverse transcription reaction progresses and the second heating unit to be a temperature at which the reverse transcriptase enzyme is not deactivated. | 10-03-2013 |
| 20130267018 | METHOD FOR PREPARING PELLETS FROM RICE HUSK AND APPARATUS FOR REMOVING ODOR USING RICE HUSK PELLET BIO-MEDIA - A method for preparing pellets from rice husk includes: grinding rice husk; adding ammonia water to a mixture of ethylene vinyl acetate and poly(vinylacetate) to prepare a mixed, liquid binder; mixing the mixed, binder with the ground rice husk to obtain a binder/rice husk mixture; extruding the binder/rice husk mixture through an extruder; and cooling the extruded mixture at room temperature. | 10-10-2013 |
| 20130288358 | MICROFLUIDIC CARTRIDGE - The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent. | 10-31-2013 |
| 20130288359 | CALIBRATABLE SENSOR UNIT FOR REACTION VESSELS - The invention relates to a reaction vessel with a sensor unit. The reaction vessel comprising a reaction space configured to be connected with the sensor unit that comprises at least one sensor device configured to be calibrated, at least one compartment containing a calibrating agent, and a housing. The sensor unit is arranged to calibrate the at least one sensor device by contact with the calibrating agent before chemical or physical parameters of a measurement substance are measured, wherein the at least one sensor device is further configured such that the relative movement between the at least one sensor device and the at least one compartment is irreversible. The at least one sensor device is movable relative to the at least one compartment from an initial position into a measurement readiness position. The reaction vessel and the sensor unit can be sterilised or are sterilised jointly. | 10-31-2013 |
| 20130309761 | APPARATUS FOR PRODUCING SACCHARIDE SOLUTION THAT USES BIOMASS AS FEEDSTOCK - There is provided an apparatus for treating a biomass feedstock at a high temperature, including a cooling means for cooling a biomass treated liquid at a high temperature; an enzymatic saccharification tank for saccharifying a cooled treated liquid with an enzyme; a solid-liquid separation apparatus for removing water-slightly soluble substances contained in a saccharide solution taken out from the enzymatic saccharification tank and a foreign substance removing unit provided with a microfiltlation (MF) membrane; a dilution tank, disposed downstream of the foreign substance removing unit, for diluting the saccharide solution from which the water-slightly soluble substances are removed by adding water thereto; a water separation unit, provided with a reverse osmosis (RO) membrane, for removing water from the diluted saccharide solution so as to obtain concentrated saccharide solution. | 11-21-2013 |
| 20130323829 | BIOLOGICAL SAMPLE HOLDER AND METHOD OF ASSEMBLING SAME - Embodiments of the invention relate to a biological sample holder and for holding biological samples. Conventionally, processing of biological samples, which may be stored on a biological sample storage medium, is done manually with samples being tested individually. However, handling of the samples is difficult and time consuming; greater demand for storage and extraction of genetic material has led to a requirement for greater throughput. In embodiments of the present invention, there is provided a biological sample holder comprising a chamber holding a biological sample storage medium, the chamber comprising one or more openings for receiving a liquid when inserted therein. This provides a means of holding a biological sample which is easy to handle and suitable for automation, for example in an array of such holders, allowing processing of multiple biological samples in parallel. | 12-05-2013 |
| 20130337553 | TRANSPLANTATION GUIDE AND TRANSPLANTATION DEVICE - The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein:
| 12-19-2013 |
| 20140017776 | DEVICES AND METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION BY ENRICHING RARE CELLS - The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of cells based on size and affinity, recovery of cells in locations on the microfluidic device, release of cells from the microfluidic device, flow of sample through the microfluidic device, and retention of rare cells from a sample obtained from a patient having a condition. | 01-16-2014 |
| 20140038278 | METHODS FOR GASIFICATION OF CARBONACEOUS MATERIALS - The present disclosure is generally directed to process of gasification of carbonaceous materials to produce synthesis gas or syngas. The present disclosure provides improved methods of gasification comprising adding a molecular oxygen-containing gas and optionally adding water into said gasifier. This disclosure is also directed to process of production of one or more alcohols from said syngas via fermentation or digestion in the presence of at least one microorganism. | 02-06-2014 |
| 20140045253 | MULTI-COMPARTMENT DEVICE FOR CELL CLONING AND METHOD OF PERFORMING THE SAME - The problems associated with the traditional methods and devices in the field of cell cloning have been solved by the multi-compartment device and method in the present invention. The device combines the advantages of a traditional petri-dish and a traditional microplate. The multi-compartment device in the present invention comprises sidewalls, which are taller than openings of the multi-compartments. The cells in the suspension flow across the multi-compartments and seed inside the compartments during a plating process. The multi-compartment device in the present invention allows easier plating process, changing conditioned medium, and cell colony detachment and transfer. The multi-compartment device also minimizes the risk of cross-contamination during cloning process and during cell colony transfer. The invention also provides an exemplary method of using the multi-compartment device for cell cloning. In one aspect of the method, the multi-compartment device may be tilted before or after adding the cell suspension during plating process. | 02-13-2014 |
| 20140045254 | CELL SELF-ASSEMBLY ARRAY CHIP AND MANUFACTURING METHOD THEREOF - A cell self-assembly array chip comprises a first substrate, a second substrate and a plurality of spacer elements. The first substrate, the spacer elements and the second substrate are stacked to be one in turn, wherein the spacer elements are annularly arranged at interval and disposed on the second substrate, so as to define a cell self-assembly region and at least one drawing channel. Furthermore, because the liquid portion of cell suspension horizontally and radially passed the drawing channel outward and the radially outward pulling force generated by the evaporation effect of the liquid portion, so as to cause the cells are arranged by the cell self-assembly array to the cell self-assembly region. The present invention further provides a manufacturing method of a cell self-assembly array chip to solve the conventional problems which is difficult to culture living cells and not easy to apply optical observation. | 02-13-2014 |
| 20140045255 | THERMAL CYCLER AND THERMAL CYCLING METHOD - A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the rotational axis is shorter than the distance between the other end portion of the biotip and the rotational axis, a heating unit heats a first end portion of the biotip, a rotating unit rotates the holder, and a controller that controls the rotation speed of the rotating unit. The controller has a first mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes smaller than the gravity, and a second mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes greater than the gravity. | 02-13-2014 |
| 20140051159 | Micro-Fluidic Modules on a Chip for Diagnostic Applications - A chip having a substrate for amplifying genetic material includes a substrate heater having a plurality of substrate heating resistors. The heating resistors define a first temperature zone for maintaining a first temperature, a second temperature zone for maintaining a second temperature below the first temperature, and a third temperature zone for maintaining a third temperature between the first and second temperatures, on the substrate. A flow path formed on the substrate allows conveying of reactions to the first temperature zone, the third temperature zone, and the second temperature zone so as to undergo denaturing, annealing, and extension, respectively, according to a polymerase chain reaction process, for at least one cycle. | 02-20-2014 |
| 20140051160 | MICRO DROPLET OPERATION DEVICE AND REACTION PROCESSING METHOD USING THE SAME - Micro droplets are accurately placed in a reaction well. The reaction well ( | 02-20-2014 |
| 20140057343 | ENERGY PRODUCTION SYSTEMS UTILIZING RUMINANT ANIMAL METHANE EMISSIONS - A process for the utilization of the methane produced by enteric fermentation, specifically to a process that utilizes methane produced by ruminant animals through enteric fermentation as a source of carbon and/or energy for the directed production of methane-based goods or processes is provided. | 02-27-2014 |
| 20140057344 | SEPARATION APPARATUS AND USE THEREOF - Separating apparatus, comprising a sedimentation settler and a collection vessel disposed underneath and being in fluid communication with the sedimentation settler, the collection vessel forming a receiving chamber having an outlet at or adjacent to the chamber bottom and having an inlet opening, wherein the collection vessel is arranged such the flow direction of the fluid in the area underneath the sedimentation settler is substantially in line with the direction of the channels of the sedimentation settler. | 02-27-2014 |
| 20140073044 | STRIPPING ABSORPTION MODULE - In a process, a portion of a liquid mixture flow is vaporized to produce a vapor and a depleted flow of liquid. The vapor is introduced to a brine which is adapted to exothermically absorb one or more components therefrom, and heat is withdrawn, to produce at least a flow of heat and a flow of brine which is enriched in the one or more components. The heat previously withdrawn is transferred, to drive the vaporization. This transfer can be associated with the change of a working fluid from a gaseous into a liquid state. In this case, the heat withdrawal involves the change of the working fluid from the liquid to the gaseous state. In the liquid state, the working fluid flows only by one or more of gravity, convection and wicking. In the gaseous state, the working fluid flows only by one or more of diffusion and convection. | 03-13-2014 |
| 20140087454 | Hepatic Lobule-Like Bioreactor - The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing | 03-27-2014 |
| 20140099705 | Cell Culture And Gradient Migration Assay Methods And Devices - A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system. | 04-10-2014 |
| 20140113360 | CELL CHIP CONTAINER FOR STORING CELL CHIP - There is provided a cell chip including: a first substrate provided with a culture region receiving a bio-material and a humidity control space storing water for maintenance of humidity; a second substrate coupled to the first substrate; and a first wall member surrounding the culture region. | 04-24-2014 |
| 20140113361 | PLANT FOR PRODUCTION OF BIOGAS - The present disclosure refers to a plant ( | 04-24-2014 |
| 20140120606 | ASEPTIC BLOW, FILL AND SEAL METHODS OF FABRICATING TEST SAMPLE CONTAINERS AND ASSOCIATED SYSTEMS AND CONTAINERS - Methods of fabricating a culture container include: (a) forming a parison; (b) introducing flowable (e.g. colorimetric) sensor material into the parison; (c) blow molding the parison into a container body; and (d) curing the sensor material so that it attaches to an inner surface of the container body. The methods can also include adding sterile growth media into the container and sealing the container shut with an elastomeric stopper and crimped seal/cap. The process can be aseptic so that autoclaving the container is not required. | 05-01-2014 |
| 20140120607 | Multi-Layered Cell Culture Vessel - A multi-layered cell culture vessel is provided herein which includes a body enclosing a closed volume. The body includes at least one insert layer located within the closed volume to separate portions thereof, and at least one port allowing communication with the closed volume from exteriorly of the body. At least one grip may be provided which protrudes from the body. Additional features may include the use of a side port which is disposed transversely to a longitudinal axis of the body, including being disposed to intersect a gap located adjacent to each of the insert layers. This arrangement allows for the preparation and removal of cell culture medium without obstruction from the insert layers. Additionally, the end of the body may be formed with tapered portions that channel flow towards an end port thereby allowing for a relatively well-defined stream to be poured from the device as needed. | 05-01-2014 |
| 20140120608 | MULTI-LAYERED CELL CULTURE VESSEL WITH MANIFOLD GRIPS - The disclosure provides a multi-layered cell culture vessel having a rectangular shape with a top a bottom sides and ends, where the sides are longer than the ends. The vessel has hand grips and ports at each end of the rectangular vessel. The ports allow fluid entering into the vessel to flow into the multiple cell culture layers through a manifold. The ports may be incorporated into the hand grips. | 05-01-2014 |
| 20140127795 | SYSTEM AND METHOD TO SIMULATE HEMODYNAMICS - A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling. | 05-08-2014 |
| 20140127796 | INSTRUMENTS FOR BIOLOGICAL SAMPLE-TO-ANSWER DEVICES - Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. | 05-08-2014 |
| 20140134715 | MICRO-PUMP - There is provided a micro-pump including: a bottom substrate; a flow path forming substrate coupled to the bottom substrate and including an inlet having a fluid introduced therein and an outlet having the fluid ejected therefrom; and a valve substrate coupled to the flow path forming substrate and including at least one valve controlling the fluid to be introduced and ejected. | 05-15-2014 |
| 20140141503 | CELL CULTURE SUBSTRATE HAVING UNIFORM SURFACE COATING - An article for culturing cells includes (i) a substrate having a surface; (ii) a plurality of pillars extending from the surface of the substrate; and (iii) a polymeric coating disposed on the surface of the substrate between the pillars, forming a plurality of mini-menisci on the surface of the substrate between the plurality of pillars. The mini-menisci may have diameters of from about 20 to about 250 micrometers. The plurality of pillars are spaced apart from one another in a manner to encourage cell growth on the mini-menisci rather than the on top of the pillars. Such articles may effectively address issues associated with the meniscus effect on a global scale. | 05-22-2014 |
| 20140147914 | BIOTIP - A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 Ω·cm and 5×10 | 05-29-2014 |
| 20140162350 | Method of Manufacturing a Sample Chamber - The invention comprises a method of manufacturing a sample chamber, comprising the steps of: providing a first ( | 06-12-2014 |
| 20140186940 | Nano-PCR: Methods and Devices for Nucleic Acid Amplification and Detection - Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying stress to a nucleic acid. These methods can provide one or more benefits over conventional PCR methods including: precision control over the PCR process; generally improved fidelity; improved accuracy over problematic sequences such as GC-rich or tandem repeat regions; greater sequence length; increased reaction yield; reduced experimental time; greater efficiency; lower cost; greater portability; and, robustness to various environmental parameters, such as temperature, pH, and ionic strengths. | 07-03-2014 |
| 20140186941 | CELL CULTURE VESSEL, AND CULTURE DEVICE EQUIPPED WITH SAME - Disclosed is a cell culture vessel of the present invention, which is composed of a space enclosed by a housing that supports a medium and a cell attachment part, disposed on the bottom surface of the space, that attaches and supports the cells, the cell attachment part having a cell immobilizing mechanism that guides the cells in the space to the cell attachment part to immobilize there and a cell detachment mechanism that detaches the cells attached in the cell attachment part, the cell immobilizing mechanism having a step of applying a voltage to an electrode disposed in the cell attachment part to generate a heterogeneous electric field in the space, and the cell detachment mechanism having a step of applying a voltage to an electrode disposed in the cell attachment part to induce electrolyte in the space. | 07-03-2014 |
| 20140193896 | High Efficiency and High Precision Microfluidic Devices and Methods - New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available. | 07-10-2014 |
| 20140206077 | PROCESSING BIOMASS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is saccharified in a vessel by operation of a jet mixer, the vessel also containing a fluid medium and a saccharifying agent. | 07-24-2014 |
| 20140242684 | SYSTEM FOR HYDROLYZING A CELLULOSIC FEEDSTOCK SLURRY USING ONE OR MORE UNMIXED AND MIXED REACTORS - Provided is a system for hydrolyzing a cellulosic feedstock slurry. The system comprises one or more unmixed reactors for receiving and partially hydrolyzing the cellulosic feedstock slurry so as to produce a mixture of partially hydrolyzed slurry. The unmixed reactors may be plug flow reactors. One or more mixed reactors are downstream of the unmixed reactors for continuing the hydrolysis of the mixture of the partially hydrolyzed slurry. The one or more unmixed and mixed reactors may be connected in series, parallel or a combination thereof. | 08-28-2014 |
| 20140242685 | INLET VALVE FOR CHAMBER SYSTEMS AND SAMPLE CONTAINERS, AND CHAMBER SYSTEMS AND SAMPLE CONTAINERS WITH SUCH INLET VALVES - An inlet valve charges an inner chamber of a system or sample container with liquid and has a first pipetting axis, an inlet opening, it supplies liquid by a laboratory pipette that is automatically reclosed and also has a valve body with a blocking element, a pressing part and a throat, a valve space enclosing the valve body at least partly near the throat, a spring mechanism and a sealing element. The throat connects the blocking element to the pressing part and has an open passage region which opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body can be brought to an open position by pressing the pressing part against the spring mechanism. | 08-28-2014 |
| 20140295539 | CONTAINER FOR CULTURING CELLS HAVING NANOSTRUCTURES, AND PREPARATION METHOD THEREOF - A container for culturing cells having nanostructures according to the present invention comprises a cell culture surface onto which adult stem cells are adhered so as to be proliferated and differentiated, wherein the cell culture surface comprises nanostructures placed thereon at regular intervals, the nanostructures comprise nano-pillars protruded from the cell culture surface, the width of the nano-pillars is 40-500 nm, and the height of the nano-pillars is 10 nm-1 μm. | 10-02-2014 |
| 20140308738 | MICROFLUIDIC DEVICE WITH INTEGRATED STIRRING STRUCTURE AND MANUFACTURING METHOD THEREOF - A microfluidic device, comprising: a semiconductor body, having a first side and a second side, opposite to one another in a first direction; and at least one well, configured for containing a fluid, extending in the semiconductor body starting from the first side and being delimited at the bottom by a bottom surface. The microfluidic device further comprises a stirring structure integrated in the well at the bottom surface, the stirring structure including a first stirring portion coupled to the semiconductor body and provided with at least one first suspended beam configured for being moved in a second direction so as to generate, in use, agitation of the fluid present in said well. | 10-16-2014 |
| 20140322803 | Carbon Sequestration Methods and Systems, and Compositions Produced Thereby - Aspects of the invention include methods of removing carbon dioxide (CO | 10-30-2014 |
| 20140329305 | DEVICES, METHODS, AND SYSTEMS FOR NUCLEIC ACID AMPLIFICATION - A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic and/or electromagnetic treatment. Also, a microfluidic device comprising at least one microcapillary device having a sample retaining element, at least one surface of which exhibits hydrophobicity, hydrophilicity, electromagnetic force exertion and electrostatic force exertion. Also, a microfluidic device comprising a first element having a hydrophilic pattern comprising at least a first sample retaining element. Also, a method comprising supplying a sample to a channel between a first element and a second element, and inducing in the first element at least one hydrophilic pattern by electrets or by internal or external electrodes to provide a charged surface. | 11-06-2014 |
| 20140377854 | MICROFLUIDIC APPARATUS, METHOD, AND APPLICATIONS - A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a nucleic acid purification step. A microfluidic device includes a dedicated liquid-liquid extraction process vessel, a nucleic acid purification process component, and a nucleic acid amplification reactor. A liquid-liquid extraction and nucleic acid purification kit includes a microfluidic device capable of performing both a liquid-liquid extraction process and a nucleic acid purification process, including a dedicated liquid-liquid extraction process vessel, an immiscible liquid or a precursor phase thereof disposed in the vessel, a nucleic acid purification process component, a nucleic acid amplification reactor fluidically, and a supply of reagents suitable to enable the liquid-liquid extraction process and the nucleic acid purification process. | 12-25-2014 |
| 20150072407 | MULTILAYER TISSUE CELL CULTURE VESSEL - The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells. | 03-12-2015 |
| 20150099293 | BUOYANT PROTEIN HARVESTING DEVICE - A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification. | 04-09-2015 |
| 20150099294 | Method and Apparatus for Reducing CO2 in a Stream by Conversion to a Syngas for Production of Energy - A system and method for producing Syngas from the CO | 04-09-2015 |
| 20150111292 | PROCESSES AND SYSTEMS FOR DISCHARGING AMINE BYPRODUCTS FORMED IN AN AMINE-BASED SOLVENT - Embodiments of a process for discharging amine byproducts formed in an amine-based solvent are provided. The process comprises the steps of contacting the amine-based solvent with flue gas comprising carbon dioxide, oxygen, nitrogen, NO | 04-23-2015 |
| 20150125946 | Horizontal Immersion Cover Type Carbon Supplement Device and Carbon Supplement Method Used for Microalgae Culture in Open Pond - The invention relates to the field of mass cultivation of microalgae and specifically relates to a horizontal submerged cover type carbon supplement device and carbon supplement method for cultivating microalgae in an open pond. The horizontal submerged cover type carbon supplement device for cultivating microalgae in an open pond, comprises: one or more than two covers and gas distributors, wherein the gas distributor is arranged at the bottom of the open pond and the cover is arranged above the gas distributor; the cover, in form of a cylinder with openings at both ends, is arranged along the flow direction of the culture solution, the two ends of the cover being a culture solution inlet and a culture solution outlet respectively; the gas distributor is kept away from the culture solution outlet of the cover by more than 40 cm. According to the invention, when microalgae cells are cultivated in the open pond, carbon dioxide can be effectively utilized for carbon supplement, so production cost is greatly reduced. | 05-07-2015 |
| 20150125947 | MICROFLUIDIC DEVICE - The invention provides a new microfluidic device and method for performing operations on droplets. The invention extends to microfluidic systems comprising one or more of the microfluidic devices. | 05-07-2015 |
| 20150132837 | MICROFLUIDIC DEVICES FOR RELIABLE ON-CHIP INCUBATION OF DROPLETS IN DELAY LINES - The present invention relates generally to droplet creation, fusion and sorting, and incubation for droplet-based microfluidic assays. More particularly, the present invention relates to delay-lines, which allow incubation of reactions for precise time periods. More particularly, the present invention relates to delay lines for incubations up to three hours, while reducing back-pressure and dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay line. | 05-14-2015 |
| 20150291924 | FERMENTER OF A BIOGAS SYSTEM - Digester of a biogas plant including a digester wall and a digester interior and a digester roof inclined to the horizontal and flexible in design and including an agitator device for stirring a substrate in the digester interior. The agitator device comprises a guiding unit, a support unit, and an adjustable agitating unit accommodated at the guiding unit. The support unit is fastened to the digester wall for supporting the guiding unit. The agitating unit is provided to be height-adjustable and an adjustment device is provided for displacing the agitating unit. The top end of the guiding unit extends up to and beyond a top end of the digester wall and terminates beneath the digester roof within the digester interior. | 10-15-2015 |
| 20150291926 | PLATFORM SYSTEM FOR IN VITRO CELL CO-CULTIVATION WITH AUTOMATIC TRAPPING FUNCTION - The present disclosure illustrates a platform system for in vitro cell co-cultivation with automatic trapping function. The platform system aims to develop a bio-chip applied in cell culture systems, and has several features. The first feature is that this co-cultivation platform can construct a micro environment suitable for culture of various cells. The second feature is dynamic perfusion. The microfluidic system is used to dynamically replace the culture medium, in order to maintain an appropriate environment for the growth of cells. The third feature is the automatic trapping. The cells to be cultured can be trapped in a suitable location according to the flow resistance, so that the damaged on the cell caused by manual operation can be minimized. | 10-15-2015 |
| 20150307828 | BIOREACTOR VESSELS AND ASSOCIATED BIOREACTOR SYSTEMS - A bioreactor vessel ( | 10-29-2015 |
| 20150321194 | SELF-LOADING MICROFLUIDIC DEVICE AND METHODS OF USE - Microfluidic devices and methods for conducting chemical assays and biological assays using microfluidic devices are disclosed. The microfluidic devices do not require external connections, tethers, tubing, valves and actuators. The microfluidic devices are useful in methods for analyzing a wide variety of chemical and biological assays such as, for example, molecule-molecule interactions, enzyme-substrate interactions, molecule identification, minimum inhibitory concentrations, therapeutically effective amounts, and toxic amounts | 11-12-2015 |
| 20150336363 | MULTILAYER FILM COMPRISING A CONTACT LAYER, CORE LAYER AND OUTER LAYER FOR THE WALL OF A SINGLE-USE POUCH - A multilayer film includes a contact layer, a core layer, and an outer layer, the contact and core layers being integral with a first tie layer; and the outer and core layers being integral with a second tie layer; the contact layer includes a copolymer of ethylene and α-olefin having a density from 0.870 to 0.910 g/cm | 11-26-2015 |
| 20150344831 | STIMULATION-RESPONSIVE MATERIAL AND CELL CULTURE CONTAINER MADE THEREOF - A stimulation-responsive material comprises regions of pH-responsive polymer and regions of temperature-responsive polymer, the regions existing at different locations. | 12-03-2015 |
| 20150345689 | ASEPTIC CONNECTORS FOR BIO-PROCESSING CONTAINERS - Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel or component. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel or component via an aseptic connector affixed to the vessel or component. The aseptic peripheral connection assembly may include a carrier, an applicator, and a removable hermetic sealing tab. | 12-03-2015 |
| 20150360450 | MULTILAYER FILM COMPRISING A CORE LAYER AND AN OUTER LAYER FOR THE WALL OF A SINGLE-USE POUCH - A multilayer film for manufacturing a pouch, includes: a core layer, and an outer layer, wherein:
| 12-17-2015 |
| 20150360843 | FILM COMPRISING A CONTACT LAYER FOR THE WALL OF A SINGLE-USE POUCH - A film for manufacturing a pouch includes a contact layer including (A) a copolymer of ethylene and α-olefin having a density in the range of 0.870 g/cm | 12-17-2015 |
| 20150361387 | BIOCHEMICAL CARTRIDGE, AND BIOCHEMICAL CARTRIDGE AND CARTRIDGE HOLDER SET - A cartridge sealed from ambient air is used to send a liquid without causing the liquid to contact the fluid inside the cartridge. Inside of the cartridge | 12-17-2015 |
| 20150376563 | CONTAINER, TRANSPORT DEVICE, USE AND METHOD - One aspect relates to a container for inserting into a holding device, comprising: a wall that is flexible at least in some areas, which wall is squashed, at least in some areas, in a transport condition in a direction opposite to a stretching direction; a handling unit connected to the wall, which is designed to come into engagement with a complementary handling unit of a transport device; a securing unit which in a transport condition hinders stretching of the wall of the bioreactor container along the stretching direction, wherein the container can, when the securing unit is released, be extended at least in some areas along the stretching direction, as well as a transport device, a use and a method. | 12-31-2015 |
| 20160002584 | CELL CULTURE DEVICE - An automatic culture device which employs closed-system culture vessels and in which, when a passage part ( | 01-07-2016 |
| 20160023210 | INLET VALVE FOR CHAMBER SYSTEMS AND SAMPLE CONTAINERS, AND CHAMBER SYSTEMS AND SAMPLE CONTAINERS WITH SUCH INLET VALVES - An inlet valve charges an inner chamber with liquid and has a first axis and an inlet opening with a tool that automatically recloses. The inlet valve has a valve body with a blocking element, and a pressing part; a valve space enclosing the valve body at least partly; a spring mechanism and a sealing element. An open passage region opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body of the inlet valve can be brought to an open position by pressing the pressing part against the resistance of the spring mechanism. Chamber systems and sample containers with such inlet valves are also disclosed. | 01-28-2016 |
| 20160032950 | TENSION CLAMP DEVICES - A mechanical clamping device can include at least two contact faces, a first of the contact faces configured to travel in response to an applied force, each contact face configured to contact a sample when loaded into the mechanical clamping device. The device can further include a load element configured to cause the two contact faces to apply a clamping force to the sample when loaded into the mechanical clamping device. | 02-04-2016 |
| 20160040107 | BIOREACTOR CONNECTORS - Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached. | 02-11-2016 |
| 20160040108 | Perfusion Bioreactor with Tissue Flow Control and Live Imaging Compatibility - A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation. | 02-11-2016 |
| 20160040116 | PROCESSING BIOMASS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce a product or intermediate, e.g., energy, a food, a fuel, or a material. | 02-11-2016 |
| 20160053220 | APPARATUS AND METHODS FOR THE SIMULTANEOUS PRODUCTION OF COMPOUNDS - The present invention provides an apparatus and methods for simultaneously producing different compounds in various ratios under set conditions. | 02-25-2016 |
| 20160068793 | MANUFACTURING WITHIN A SINGLE-USE CONTAINER - A manufacturing assembly has at least a sterilizable chamber containing at least one of a three-dimensional printing device (additive manufacturing), a Computer Numerical Controlled (CNC) finishing head (subtractive manufacturing), a vacuum-forming unit, an injection-molding unit, a laser-cutting unit, a ultrasonic-welding unit, a robotic arman analysis device, a sampling device or a combination thereof. A plurality of individual sterilizable chambers may be aseptically connected into a network of sterilizable chambers that provides additional functionality for the manufacturing assembly. A sterilizable printer assembly may include at least one printing head, a printing platform, and a driving mechanism adapted to perform a movement of the at least one printing head relative to the printing platform along three degrees of freedom; a printer housing enclosing the printer assembly in a sterile manner, at least one aseptic connector fluidly connected to a corresponding one of the at least one printing head. | 03-10-2016 |
| 20160083680 | BIOMATERIAL HANDLING DEVICE - A biomaterial handling device is described that will provide for functionality for performing both IVF procedures and washing techniques in a single device. Disclosed embodiments provide increased protection to biomaterial samples during processing and handling. Embodiments of the invention reduce labor intensive processes for both IVF and washing treatments and address reduced risks of contamination of biological samples by providing an increasingly sterile environment. | 03-24-2016 |
| 20160083682 | Unitary 3D Culture Device - A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas. The device is particularly useful for culturing bone cells for dental implants or bone reconstruction. | 03-24-2016 |
| 20160089674 | THERMAL CYCLER - A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 Ω·cm and 5×10 | 03-31-2016 |
| 20160096176 | MICROFLUIDIC STRUCTURE - A microfluidic structure comprising a thermoplastic portion ( | 04-07-2016 |
| 20160102282 | APPARATUS FOR APPLYING ELECTRIC FIELD - An apparatus for applying an electric field includes: a base, on which an internal region is defined, a plurality of electrodes disposed to face each other in parallel in the internal region of the base, and a sample plate disposed between the plurality of electrodes. | 04-14-2016 |
| 20160107160 | Microfluidic Size-Exclusion Devices, Systems, and Methods - Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided. | 04-21-2016 |
| 20160115432 | Symbiotic Algae System - According to present disclosure, there is disclosed an algae growth and cultivation system that provides a cost-efficient means of producing algae biomass as feedstock for algae-based products, such as, biofuel manufacture, and desirably impacts alternative/renewable energy production, nutrient recovery from waste streams, and valued byproducts production. The system as discussed herein is an integrated systems approach to wastewater treatment, algal strains selection for byproducts production, and recycle of algal-oil extraction waste or additional algae harvested as feedstock for fertilizer production. Embodiments of a system as discussed herein present an economically viable algae production system and process that allows algae-derived products such as biofuels, fertilizer, etc. to compete with petroleum products in the marketplace. | 04-28-2016 |
| 20160122700 | DISPERSING FEEDSTOCKS AND PROCESSING MATERIALS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is dispersed in a liquid medium and then saccharified. | 05-05-2016 |
| 20160129446 | MICROFLUIDIC DEVICES WITH INTEGRATED RESISTIVE HEATER ELECTRODES INCLUDING SYSTEMS AND METHODS FOR CONTROLLING AND MEASURING THE TEMPERATURES OF SUCH HEATER ELECTRODES - The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one aspect, the present invention provides a method for controlling the temperature of a heater electrode associated with a microfluidic channel of a microfluidic device, wherein power applied to the heater electrode is regulated by varying the duty cycle of a pulse width modulation (PWM). In another aspect, the present invention a controller configured to compute the temperature of the heater electrode during the power-on portion of the duty cycle and the during the power-off portion of the duty cycle and to adjust the duty cycle as necessary to achieve a desired temperature in the heater electrode. | 05-12-2016 |
| 20160130549 | MICROBIAL PRODUCTION OF MULTI-CARBON CHEMICALS AND FUELS FROM WATER AND CARBON DIOXIDE USING ELECTRIC CURRENT - The invention provides systems and methods for generating organic compounds using carbon dioxide as a source of carbon and electrical current as an energy source. In one embodiment, a reaction cell is provided having a cathode electrode and an anode electrode that are connected to a source of electrical power, and which are separated by a permeable membrane. A biological film is provided on the cathode. The biological film comprises a bacterium that can accept electrons and that can convert carbon dioxide to a carbon-bearing compound and water in a cathode half-reaction. At the anode, water is decomposed to free molecular oxygen and solvated protons in an anode half-reaction. The half-reactions are driven by the application of electrical current from an external source. Compounds that have been produced include acetate, butanol, 2-oxobutyrate, propanol, ethanol, and formate. | 05-12-2016 |
| 20160138084 | CARTRIDGE SET - A cartridge set includes: a first package; a cleaning container that is accommodated and sealed in the first package while accommodating and sealing a cleaning solution for cleaning a nucleic acid-binding solid-phase carrier to which nucleic acid adheres; an elution container that is accommodated and sealed in the first package while accommodating and sealing an elution solution which elutes the nucleic acid from the nucleic acid-binding solid-phase carrier; a second package; and a reaction container that is accommodated and sealed in the second package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction. The first package has water permeability that is lower than that of the cleaning container and the elution container. The second package has water permeability that is lower than that of the reaction container. | 05-19-2016 |
| 20160138085 | CARTRIDGE SET - A cartridge set includes: a first package; a cleaning container that is accommodated and sealed in the first package while accommodating and sealing a cleaning solution for cleaning a nucleic acid-binding solid-phase carrier to which nucleic acid adheres; a second package; an elution container that is accommodated and sealed in the second package while accommodating and sealing an elution solution which elutes the nucleic acid from the nucleic acid-binding solid-phase carrier; a third package; and a reaction container that is accommodated and sealed in the third package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction, in which the first package has water permeability that is lower than that of the cleaning container, the second package has water permeability that is lower than that of the elution container, and the third package has water permeability that is lower than that of the reaction container. | 05-19-2016 |
| 20160145554 | INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS - The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems. | 05-26-2016 |
| 20160145557 | Reactor vessel useful for performing multiple pretreatments - The present invention provides for a reactor vessel comprising a reaction chamber comprising an inner surface configured for performing multiple pretreatments. | 05-26-2016 |
| 20160145558 | CO-INCUBATING CONFINED MICROBIAL COMMUNITIES - This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices. | 05-26-2016 |
| 20160145560 | DEVICE FOR MICROBIAL CULTIVATION WITH OPTIONS FOR FIELD STERILIZATION AND GAS GENERATION - A microbiological cultivation method, and a device for its use is equipped with field-capable system for producing optimal culture conditions for aerobic, microaerobic and anaerobic microbes. They are further equipped with possibilities for independent clean up and sterilization, as well as for gas supply, generation and regulation. This device and method can be used for clinical, environmental and industrial microbial monitoring tasks. | 05-26-2016 |
| 20160145561 | BIOREACTOR SYSTEM WITH A TEMPERATURE SENSOR - A bioreactor system comprising a base station comprising a control system, a tray arranged to be provided on the base station and arranged to house a bioreactor bag, wherein said base station comprises at least one temperature sensor means and in that said tray comprises at least one opening for receiving said temperature sensor means such that it will contact a surface of a bioreactor provided in the tray. | 05-26-2016 |
| 20160151749 | RECEPTACLE COMPRISING A SHAFT HOUSING | 06-02-2016 |
| 20160152936 | BIOREACTOR CONSUMABLE UNITS | 06-02-2016 |
| 20160152938 | A TEMPERATURE SENSOR MEANS AND A BIOREACTOR SYSTEM COMPRISING A TEMPERATURE SENSOR MEANS | 06-02-2016 |
| 20160160167 | WORKING CHAMBER - A working chamber including: a body case including a work space in an interior thereof; a supply unit configured to supply gas through a supply filter provided at the upper front of the work space; a louver that guides gas to a back surface side of the work space after the gas passes through the supply filter; and an illuminating means positioned lower than the louver and in front of the louver, at least one surface of the louver, which faces the illuminating means, being a reflection surface. | 06-09-2016 |
| 20160177512 | FINE CELLULOSE FIBER SHEET | 06-23-2016 |
| 20160186124 | CELL CULTURING SYSTEM FOR CULTIVATING ADHERENT CELLS AND LIQUID SUPPLY INTERFACE COMPRISING A CELL CULTURE CONTAINER - The invention relates to a liquid supply interface ( | 06-30-2016 |
| 20160194589 | CELL CULTURE BAG WITH INTERNAL DIALYSIS MEMBRANE | 07-07-2016 |
| 20160194595 | SYSTEMS FOR INACTIVATING FLUID CULTURES THROUGH HEATING | 07-07-2016 |
| 20160195081 | ELECTRONICALLY CONTROLLED DIAPHRAGM PUMP | 07-07-2016 |
| 20160201021 | DEVICE FOR THE ASEPTIC EXPANSION OF CELLS | 07-14-2016 |
| 20160250635 | MICROFLUIDIC CARTRIDGE | 09-01-2016 |
| 20190144810 | A DEVICE FOR CELL CULTURE | 05-16-2019 |
| 20190144811 | INSTALLATION FOR BIOTECHNOLOGICAL APPLICATIONS, WITH CARRIER FOR THE MOUNTING OF COMPONENTS | 05-16-2019 |
| 20220135923 | DYNAMIC POLYMER SURFACES FOR SCREENING, ENRICHMENT, AND HARVESTING OF CELLS AND OTHER SOFT COLLOIDAL PARTICLES - Dynamic polymer surfaces are provided that include alternating micropatterns of adhesive domains and environmental stimuli-responsive repulsive domains, where application of a select environmental stimulus activates polymer structures of the repulsive domains to change conformation with respect to the adhesive domains. The dynamic polymer surfaces are useful for sorting, screening, and enriching target particles (such as cells) in a sample and for culturing and harvesting cells. Products, such as cell culture systems, including the dynamic polymer surfaces are also provided. | 05-05-2022 |
| 20220135925 | CONTINUOUS AUTOMATED PERFUSION CULTURE ANALYSIS SYSTEM (CAPCAS) AND APPLICATIONS OF SAME - A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. | 05-05-2022 |
| 20220135926 | BIOPROCESS DEVICE ASSEMBLY AND INOCULATION METHOD - A bioprocess device assembly includes at least a first bioreactor and a second bioreactor, and a transfer system for transferring a certain volume of a medium contained in the first bioreactor into the second bioreactor. A biomass sensor is associated to the first bioreactor. A control unit is configured for receiving measurement data from the biomass sensor and controlling the transfer system. An inoculation method makes use of such a device assembly wherein the biomass sensor measures at least one parameter of biomass contained in the first bioreactor; the biomass sensor sends measurement data to the control unit; and the control unit evaluates the measurement data and, based on an evaluation of the measurement data decides whether the viable cell density is sufficient for inoculation, determines a necessary inoculation volume, and controls the transfer system to transfer the determined inoculation volume from the first bioreactor into the second bioreactor. | 05-05-2022 |
| 20220135928 | DEVICE AND METHOD FOR DETERMINING OPERATION CONDITION OF BIOREACTOR - Disclosed are a method and a device for determining an operating condition of a bioreactor. Each of the method and the device receives N experimental data sets, models the bioreactor using the N experimental data sets to construct a bioreactor model, and determines an optimal operation condition based on an operation scheme of the bioreactor, using the constructed bioreactor model. | 05-05-2022 |
