Entries |
Document | Title | Date |
20080299651 | Thermal cycle for automatic performance of the polymerase chain reaction with close temperature control - A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction. | 12-04-2008 |
20090004732 | Chemical Temperature Control - Exothermic and/or endothermic chemical reactions in combination with phase change materials can produce output temperature(s) within strict tolerances without requiring expensive and complicated external equipment to generate and maintain an output temperature. Similarly, an exothermic phase change material, which generates heat as a consequence of crystallizing a supercooled liquid, can generate heat at a constant temperature, without requiring expensive and complicated external equipment, as a consequence of the liquid form of the exothermic phase change material being in equilibrium with the solid form of the exothermic phase change material. Numerous biological and chemical processes and/or diagnostic devices require a constant temperature or temperatures for set periods of time. An example completely non-instrumented diagnostic platform based on nucleic acid amplification is described, which is particularly suited for use in developing countries that may not have access to expensive and complicated external equipment. | 01-01-2009 |
20090011495 | Incubator Apparatus and Method - The present invention relates to a method of processing analyte using a portable incubator apparatus. The incubator apparatus | 01-08-2009 |
20090029454 | SAMPLE BLOCK APPARATUS AND METHOD FOR MAINTAINING A MICROCARD ON A SAMPLE BLOCK - A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control system operatively connected with the sample block. The upper surface of the sample block may include a plurality of channels, the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that a retention force is imparted on the microcard to urge the microcard toward the sample block. Methods of maintaining a microcard on a sample block of a thermal cycling device are also provided. | 01-29-2009 |
20090068728 | Cell incubator - A cell incubator having an observation unit to observe a cell incubation process comprises: a focus detecting unit to detect a focus position of an imaging optical system of the observation unit; an optimum focus selecting unit to select an optimum focus position based upon a plurality of images taken by moving the imaging optical system stepwise at a fine pitch along an optical axis direction from the focus position, based upon the focus position detected by the focus detecting unit; and a fluorescence observation unit to shoot a fluorescence image of the cells by moving the imaging optical system to the optimum focus position thus detected by the optimum focus selecting unit. | 03-12-2009 |
20090075365 | Culture Device - A culture device containing a culture vessel for culturing a cell, in which the culture device includes a thermostatic vessel having a stacker containing a plurality of culture vessels for culturing a cell, and an observation portion arranged to be isolated from an atmosphere at inside of the thermostatic vessel and having an object lens, an object lens drive portion, and a camera portion to observe a cell at inside of the culture vessel installed at an observation position at inside of the thermostatic vessel. | 03-19-2009 |
20090087903 | Temperature control device with a flexible temperature control surface - A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber. | 04-02-2009 |
20090117648 | VESSEL AND METHOD OF MANUFACTURE THEREOF - The invention concerns a novel sample tube and a method of manufacturing a such a sample tube. According to the method an oversized mould cavity is formed with an opposing pair of mould members of an injection moulding machine, the mould members being movable relative to each other and between which mould members the sample tube is formed. A volume of resin exceeding the prescribed volume of the sample tube is injected into the cavity and force is applied to said mould members in order to reduce the volume of said mould cavity for displacing molten polymer in the cavity and for compressing the polymer to form said sample tube. By means of the invention, sample tubes and vessels having ultra thin walls can be manufactured. | 05-07-2009 |
20090162929 | NUCLEIC ACID AMPLIFICATION APPARATUS AND THERMAL CYCLER - A thermal cycler is provided that may be used as a nucleic acid amplification apparatus. The cycler has at least three temperature zones that can be set at different temperatures, the temperature zones including a first temperature zone, an intermediate zone, and a second temperature zone. The cycler has a channel including a plurality of forward subchannels and a plurality of backward subchannels, with the forward subchannels being different from the backward subchannels in terms of cross-sectional area in the intermediate zone. The channel is configured to continuously flow a fluid alternately through one of the forward subchannels and one of the backward subchannels, so that the fluid travels repeatedly between the first temperature zone and the second temperature zone via the intermediate zone, whereby the fluid is thermally cycled while the fluid flows through the channel. | 06-25-2009 |
20090186404 | APPARATUS FOR AMPLIFYING NUCLEIC ACIDS - Provided is a nucleic acid amplifying apparatus having a uniform distribution of reaction temperature in a reaction space. The nucleic acid amplifying apparatus includes a substrate providing a polymerase chain reaction (PCR) space, and a plurality of heating units disposed above or below the reaction space to transfer heat to the reaction space, wherein the heating unit includes a plurality of heating units arranged substantially in parallel with each other, and among the plurality of heating units, the heating units disposed adjacent outermost portions of the reaction space have the largest heat radiation quantity. | 07-23-2009 |
20090203120 | Thermal Cycling Apparatus and Method for Providing Thermal Uniformity - An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling. | 08-13-2009 |
20090209030 | Thermal Cycler - A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit material or a circuit board material. The second thermalcycler body section has a second face. A second cavity portion is formed in the second face. When the first cavity portion and the second cavity portion are positioned together they form a cavity. A thermalcycler unit is positioned in the cavity. The first thermalcycler body section and the second thermalcycler body section are connected together with the first face and the face opposed to each other and the thermalcycler unit operatively connected to the first cavity portion and the second cavity portion. | 08-20-2009 |
20090221064 | INCUBATOR FOR ISOLATOR - There is provided an incubator for an isolator, which is capable of reliably sterilizing a cultivation room of the incubator, a gas supply pipe and a sampling pipe. An incubator | 09-03-2009 |
20090286309 | Device for producing a biologically active substance - A device, a method and a system that are used for producing at least one biologically active substance. The device has at least one unit ( | 11-19-2009 |
20100015695 | METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS - A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate. | 01-21-2010 |
20100062522 | Incubation system with low temperature enclosure - An incubator is fitted with an enclosure which surrounds the incubator. A cold air generation system supplies relatively cold air to a space formed between enclosure and the incubator. The system supplying the cold air can be embodied in a cart or base upon which the incubator sits. The enclosure is also placed on the base in a manner such that it substantially envelops the incubator. The top of the cart has openings for egress of cold air and return of air so that air may circulate in a closed loop. The incubator, cold air supply system and enclosure present a solution for incubating samples in a nominal 20-25° C. temperature environment. The enclosure, which is preferably insulated, may include a void or opening which exposes doors or other access device of the incubator, allowing direct access to the samples in the incubator while the rest of the incubator is enveloped by the enclosure. | 03-11-2010 |
20100081191 | ANISOTROPIC HEAT SPREADER FOR USE WITH A THERMOELECTRIC DEVICE - A well block for use with a Polymerase Chain Reaction (PCR) Cycler may include a body for holding a plurality of specimen vials, a base for attaching the well block to a temperature control device, and a temperature plate coupled to the base. Further, the temperature plate may include an anisotropic material for transferring thermal energy between the body and the temperature control device. | 04-01-2010 |
20100112683 | Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control - A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction. | 05-06-2010 |
20100120138 | ENHANCED FEEDSTOCK FOR USE WITH MICRO-REFINERIES - An ethanol production system includes a feedstock distributor and a micro-refinery. The feedstock distributor can pre-ferment and pre-distill the feedstock so that the ethanol content can be between 15% and 50%. This processing can improve the ethanol production efficiency because less waste material is transported from the distributor to the micro-refineries and less time is needed by the micro-refineries to produce ethanol. | 05-13-2010 |
20100136675 | Incubation and Dry Storage Apparatus - An incubation and dry storage apparatus, especially for samples made of organic material, is provided. | 06-03-2010 |
20100136676 | MODULAR CONTINUOUS PRODUCTION OF MICRO-ORGANISMS - Process for the growing of micro-organism in an open and continuous system further being characterized by means for creating within said system a habitat in which natural, diverse and heterogeneous emicrobial communities can autonomously react and adapt to a changing environment | 06-03-2010 |
20100159582 | DISPOSABLE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) CHIP AND DEVICE - A polymerase chain reaction (PCR) device including a chip assembly, a plurality of chambers being provided in said chip assembly adapted to hold samples, heating means wherein said chip assembly being located on said heating means whereby said chip assembly is allowed to operatively rotate on said heating means, a rotary wheel aiding said chip rotation and wherein said heating means comprises of plural temperature zones in a manner that on rotation of said chip means said sample chamber is shifted from one temperature zone to another by means of a rotary-linear motion system. | 06-24-2010 |
20100173399 | FUEL PRODUCTION - An apparatus that includes a first reactor and a return mechanism. The first reactor has an inlet to receive a mixture comprising a first reactant, a second reactant, a reaction product, and an inert solvent that dissolves at least a portion of the first and second reactants, an enzyme to facilitate a reaction between the first and second reactants to generate more reaction product, and an outlet to output the reaction product, including the reaction product received at the inlet and the reaction product generated from the reaction between the first and second reactants. The return mechanism sends at least a portion of the reaction product from the outlet back to the inlet. | 07-08-2010 |
20100173400 | Thermal Cycler for PCR - An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. | 07-08-2010 |
20100173401 | CULTURE APPARATUS - A culture apparatus includes a culture chamber in which culture is cultured, a shelf plate included in the culture chamber, on which the culture is placed, and shelf rests in a left-and-right pair configured to support the shelf plate and a plurality of shelf supports configured to support the shelf rests. The shelf rests each include one piece supporting the shelf plate and the other piece supported by the shelf supports. The shelf rests are in an L-shape in a cross-sectional manner whose angle between the one piece and the other piece is an acute angle. The one piece is in line contact with a lower face of the shelf plate at an end of the one piece extending obliquely upward from a side face of the culture chamber toward the inside of the culture chamber. The culture chamber is supplied with sterilizing gas to be sterilized. | 07-08-2010 |
20100173402 | Methods and Compositions for Isolating Metastatic Cancer Cells, and Use in Measuring Metastatic Potential of a Cancer Thereof - The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells. | 07-08-2010 |
20100216229 | CELL CULTURE SYSTEM WITH MANIFOLD - A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves. | 08-26-2010 |
20100233798 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME - Provided are a centrifugal force-based microfluidic device, in which biochemical treatments of samples are executed, and a method of fabricating the centrifugal force-based microfluidic device. The centrifugal force-based microfluidic device is mountable on a rotatable device and includes: a disk-shaped portion; and an inlet hole defined within, configured to receive fluid from outside the centrifugal force-based microfluidic device having a first opening with a first inner diameter, and a second opening disposed on the first opening having a second inner diameter greater than the first inner diameter, and a depth of the second opening greater than a height of a fluid droplet formable in the second opening. | 09-16-2010 |
20100240124 | SAMPLE PROCESSING DEVICE COMPRESSION SYSTEMS AND METHODS - Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface. | 09-23-2010 |
20100285576 | Method to produce synthesis gas or liquid fuels from commingled algae and coal feedstock using a steam-hydrogasification reactor and a steam methane reformer with CO2 utilization through an algae farm - This invention involves the conversion of coal-algae or resid-algae commingled slurry feedstock into a high methane content product gas using a steam hydrogasification process. This gas is then reformed into synthesis gas (H | 11-11-2010 |
20110008881 | THERMAL CYCLING DEVICE WITH SELECTIVELY OPENABLE SAMPLE PORT - A device for thermal cycling a plurality of samples, the device including a chamber for housing a plurality of sample containers, the chamber having a selectively openable port, wherein one or more selected sample containers can be introduced to or withdrawn from the chamber through the port during thermal cycling. | 01-13-2011 |
20110033919 | METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME - A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented. | 02-10-2011 |
20110070637 | Thermal cycler - A thermal cycler includes a bearing element, a heating element, a first cooling element, and a temperature controller. The bearing element carries at least one reaction mixture. The heating element raises the temperature of the reaction mixture. The heating element includes a housing, at least one carbon nanotube structure and a pair of electrodes. The carbon nanotube structure and the pair of electrodes are accommodated in the housing. The pair of electrodes is electrically connected to the carbon nanotube structure. The first cooling element cools the temperature of the reaction mixture. The temperature controller is electrically connected to the heating element and the first cooling element. The temperature controller controls the operation of the heating element and the first cooling element | 03-24-2011 |
20110081713 | System and Apparatus for Feeding, Solubilizing, Growing and Discharging a Biological Material - Apparatus useful for feeding a particulate starter material comprising nutrient and bacteria to a mixing tank, for solubilizing the starter material inside the mixing tank, for promoting growth of the bacteria and for discharging an aqueous slurry comprising the bacteria from the mixing tank. The apparatus preferably has a gravity-flow feeder and discharge port, does not require a pump, and comprises disposable parts. | 04-07-2011 |
20110129914 | THERMOCYCLING OF A BLOCK COMPRISING MULTIPLE SAMPLE - The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a system and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in a microtiter plate format. | 06-02-2011 |
20110136219 | THERMAL CYCLING APPARATUS AND METHOD FOR PROVIDING THERMAL UNIFORMITY - An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling. | 06-09-2011 |
20110183411 | SELF-STERILIZING AUTOMATED INCUBATOR - A method and system for self-sterilizing an automated incubator is disclosed. The internal temperature of the automated incubator is elevated by forcing hot air to flow into the internal incubation chamber, wherein all mechanics and electronics associated with the automated plate mover are outside the internal incubation chamber. During sterilization, the heating system of the automated incubator will force hot air to flow over the internal surfaces of the incubator, thereby reducing contaminating microorganism resistance by inducing dehydration. | 07-28-2011 |
20110189765 | INCUBATOR - An incubator including a cultivating chamber for cultivating cultures, a water supply control unit for supplying water into the cultivating chamber through a water supply passage and adjusting the humidity of the inside of the cultivating chamber, and a filter provided in the water supply passage. | 08-04-2011 |
20110212516 | FLOW-BASED THERMOCYCLING SYSTEM WITH THERMOELECTRIC COOLER - Thermocycling system, including methods and apparatus, for performing a flow-based reaction on a sample in fluid. The system may include a plurality of segments defining at least two temperature regions, and also may include a plurality of heating elements configured to maintain each temperature region at a different desired temperature. At least one of the heating elements may be a thermoelectric cooler operatively disposed to transfer heat to and/or from a temperature region The system further may include a fluid channel extending along a helical path that passes through the temperature regions multiple times such that fluid flowing in the channel is heated and cooled cyclically. | 09-01-2011 |
20110263010 | INCUBATOR DEVICE AND METHOD - The invention provides an incubation device, comprising an incubator chamber ( | 10-27-2011 |
20110318824 | CARTRIDGE SYSTEM FOR CHEMICAL PROCESSING - An end portion of a head has a recess having an inner shape corresponding to a dome shape of a well when the well is in an expanded state. The radius of curvature of the recess is larger than the radius of curvature of the dome shape of the well. Moreover, the depth of the recess is smaller than the height of the dome shape of the well. Therefore, the head first contacts the apex of the well, and the contact area gradually expands toward the outer periphery. At this time, a gap is generated between the head and the cartridge around the well. Thus, the air between the head and the well is expelled from around the well as the head is pressed against the well. | 12-29-2011 |
20120058552 | SAMPLE PROCESSING UNITS, SYSTEMS, AND RELATED METHODS - Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided. | 03-08-2012 |
20120083030 | INCUBATOR - An incubator comprising: a culture chamber configured to accommodate culture; a dish structure configured to contain a liquid; an ultrasonic vibrator provided in a part of the dish structure, the ultrasonic vibrator configured to atomize the liquid; and a gas-liquid contact structure configured to bring the atomized liquid into contact with air in the chamber to be cultured. | 04-05-2012 |
20120122201 | Gas Flow Rate And Liquid Level Monitoring Apparatus - An incubator ( | 05-17-2012 |
20120184028 | Micro IVF chamber - A micro IVF chamber that enables rapid filling, hermetic sealing, and custom gas environment control for secure cell extraction, fertilization, culturing, insemination, macro and microscopic content examination, post examination rapid refilling, return to optimal gas levels and pH values, with direct view of cell in conventional microscopes while maintaining culture environment, designed for use in any incubator and multiple devices per shelf for optimum efficiency while maintaining integrity of individual devices and patient-culture identity in a simple one-sample clamp-and-go device is disclosed. | 07-19-2012 |
20120258528 | CULTURE APPARATUS - A culture apparatus comprising: a fan configured to circulate air inside a culture chamber in a predetermined direction in the culture chamber; a duct configured to guide air circulating inside the culture chamber along a wall face inside the culture chamber from an upper part to a lower part of the culture chamber; and a gas generator detachable from a predetermined position at a lower part of the duct, the gas generator being configured to take in air discharged from a lower part of the duct and discharge together with the air taken in a hydrogen peroxide gas to sterilize the inside of the culture chamber generated from a hydrogen peroxide solution into the culture chamber. | 10-11-2012 |
20120264206 | Device for the Carrying Out of Chemical or Biological Reactions - The invention relates to a device for performing biological reactions in a nucleic acid sample. The device can comprise a reaction vessel receiving element that includes a plurality of reaction vessel holders and a gastight jacket or equalization plate containing a fluid changeable between liquid and gaseous states. The gastight jacket or equalization plate can be configured to provide temperature equalisation among the reaction vessel holders. The reaction vessel receiving element can also include at least one Peltier element, a cooling element, and a controller configured to cycle the device through a predetermined time-temperature profile via heating and cooling. | 10-18-2012 |
20120270309 | THERMAL CYCLER - A thermal cycler for incubating reaction mixture, the thermal cycler including:(1) a heat block for holding and heating reaction containers which contain the reaction mixture, the heat block being a double-layered structure of a lower layer heat block and an upper layer heat block; and (2) a thermal control means for controlling a temperature of the lower layer heat block and a temperature of the upper layer heat block independently and respectively and keeping the temperature of the upper layer heat block higher than the temperature of the lower layer heat block while incubating the reaction mixture. Since the thermal cycler prevents the occurrence of the condensation of water or other components of the reaction mixture in the reaction container and the thermal differences based on the installation positions of the reaction containers, the PCR method and the other enzyme reaction can be performed in a good repeatability. | 10-25-2012 |
20120309083 | METHODS AND APPARATUSES FOR CONVECTIVE POLYMERASE CHAIN REACTION (PCR) - The present invention provides a method and apparatus for amplifying a nucleic acid sequence by polymerase chain reaction (PCR). The method comprises placing a PCR sample in a container which is heated by only a single heat source that provides a high temperature for denaturation in the bottom of the PCR sample, while annealing and extension automatically occur in different regions of the PCR sample due to the convection induced by a temperature gradient descending from the bottom of the PCR sample to the surface of the PCR sample. | 12-06-2012 |
20130059372 | SAMPLE PROCESSING UNITS, SYSTEMS, AND RELATED METHODS - Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided. | 03-07-2013 |
20130078713 | Thermal Cycler For PCR - An assembly for cycling vials of reaction mixtures through a series of temperature excursions is provided. The assembly can include a sample block for receiving the vials, a plurality of thermoelectric devices, a heat sink, and a clamping mechanism positioned to clamp the thermoelectric devices between the sample block and heatsink. The assembly can also include a thermal connector having a first end and a second end, the first end in close contact with the sample block and the second end in close contact with the heatsink to provide a thermal path between the sample block and the heatsink, the thermal connector being positioned to reduce thermal gradients across the sample block. The assembly can further include means for connecting the assembly to a computing apparatus for controlling the temperature excursions of the assembly. | 03-28-2013 |
20130078714 | CULTURE APPARATUS PROVIDED WITH HEAT PIPE - A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas in the culture vessel; a humidifying pan disposed on the bottom of the culture vessel and positioned inside the duct; a heat pipe having a heat insulating section, a heat input section disposed at one end of the heat insulating section and a heat dissipation section disposed at the other end of the heat insulating section. The heat pipe is attached to the culture apparatus with the heat dissipation section being disposed outside the culture apparatus, the heat insulating section passing through the heat insulating box main body and the inner box, and the heat input section being disposed in a gas passage in the duct. | 03-28-2013 |
20130089924 | CULTURE APPARATUS HAVING HEATERS - A culture apparatus includes a heat insulating box main body having an inner box and a heat insulating door, a culture vessel, a duct and a circulation blower forcing convection of a gas such as air in the culture vessel, a humidifying pan disposed on a bottom portion of the culture vessel within the duct, and heaters disposed on the outer side of the inner box and on the inner side of the heat insulating door, for heating the inside of the culture vessel. The culture apparatus is configured such that a rapid heater is provided on the downstream side of the circulation blower inside the duct, and the rapid heater is activated if a temperature in the culture vessel is decreased below a prescribed temperature, thereby rapidly regaining the prescribed temperature. | 04-11-2013 |
20130115691 | THERMO-CONDUCTIVE CELL CULTURE DISH HOLDER - The present invention describes various devices for holding cell culture dishes in a secure manner and to ensure rapid and uniform heat transfer to and from the cell culture dish. | 05-09-2013 |
20130164832 | MICROFLUIDIC DEVICES HAVING A REDUCED NUMBER OF INPUT AND OUTPUT CONNECTIONS - Provided herein are systems and methods for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. For example, provided herein is a device with three groups of independently controllable components, where the first group includes a first lead and a first heater configured to heat a valve; where the second group includes a second lead and a second heater configured to heat a reaction chamber; where the third group includes a third lead and the first and second heaters; and where the first heater is independently controllable via a combination of the first lead and the third lead, and the second heater is independently controllable via a combination of the second lead and the third lead. | 06-27-2013 |
20130230915 | Pasting Edge Heater - An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module. | 09-05-2013 |
20130273646 | INCUBATOR AND CARRIER SYSTEM - An incubator includes: a mount table having placed thereon a container, a holding member holding the container, or a storage member storing the holding members in a vertical-multi-stage manner; a carrying-in door on one side-face of the incubator including first and second antennas in an interior; a discrimination unit to determine that the container or holding member is placed on the table if radio waves are transmitted/received between the first antenna and a tag of the container or holding member, and determine that the storage member is placed if radio waves are transmitted/received between the second antenna and the tag of the holding member in the storage member; and a warning unit to warn if the container or holding member is placed thereon and a specified storage destination is a place for storage member, or the storage member is placed and the destination is a place for holding member. | 10-17-2013 |
20130330818 | THERMAL CYCLER - A thermal cycler includes: a first mounting unit and a second mounting unit which are cylindrical; a temperature gradient forming unit which forms a temperature gradient along mounting directions of the first mounting unit and the second mounting unit; and a driving mechanism which rotates the first mounting unit, the second mounting unit, and the temperature gradient forming unit around a rotating shaft having a component perpendicular to a direction in which gravity is applied and a component intersecting the mounting directions of the first mounting unit and the second mounting unit, wherein the first mounting unit and the second mounting unit are disposed on opposite sides to each other with the rotating shaft interposed therebetween, the mounting direction of the first mounting unit and the mounting direction of the second mounting unit are in the same direction. | 12-12-2013 |
20140030802 | Conditioning chamber for storing samples in a time-controlled manner and method for storing samples in a time-controlled manner - The invention relates to an air-conditioning space ( | 01-30-2014 |
20140051161 | Micro-Fluidic Modules on a Chip for Diagnostic Applications - A micro-fluidic device includes a plurality of heaters on a substrate for heating the substrate. The plurality of heaters define a plurality of temperature regions having distinct temperatures on the substrate. A flow feature layer is formed above the substrate to define a channel extending across the substrate through each temperature region. As fluid is repeatedly pumped within the channel, it flows from one temperature region to a next temperature region to undergo thermal cycling. | 02-20-2014 |
20140193898 | SYSTEM FOR PRODUCING A BIOGAS - A method for producing a biogas is provided. The method includes the steps of providing a polyculture of aquatic plants to a growth system; continuously providing water, carbon dioxide, air and nutrients to the polyculture contained within the growth system; growing the polyculture for a time sufficient to produce an aquatic plant-based biomass; withdrawing a portion of the aquatic plant-based biomass contained within the growth system; and treating the withdrawn aquatic plant-based biomass to produce a biogas. | 07-10-2014 |
20140273200 | Apparatus for optimizing temperature for fermentation process inside of a variety of enclosures. - An apparatus designed to be placed inside of variety of enclosures to control the temperature inside of the enclosure to create optimal fermentation conditions, consisting of: heater, controller, temperature sensor and optionally a fan. The apparatus fits inside of an independent enclosures of various sizes and types, typically thermally insulated such as existing coolers. Such apparatus placed inside an enclosure can create optimal temperature inside the enclosure for fermentation of various yeast and bacteria as would be used for example in preparation of foods such as yogurt, kimchi, kefir and proofing of baked goods. | 09-18-2014 |
20140287489 | Micro-Incubation Systems For Microfluidic Cell Culture And Methods - A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems. | 09-25-2014 |
20140329307 | Method and Device for Conducting Biochemical or Chemical Reactions at Multiple Temperatures - Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction volumes through various reaction zones having different temperatures on a microfluidics apparatus. The devices comprise a microfluidics apparatus comprising appropriate actuators capable of moving reaction droplets or reaction volumes through the various reaction zones. | 11-06-2014 |
20140356940 | WASTE BIOFERMENTER, BASED ON TEMPERATURE CONTROL BY MEANS OF HEATING AND COOLING AN ADDED LIQUID OR GASEOUS SOLUTION FOR ENERGY-USE OPTIMIZATION - The present invention comprises a waste-bio-fermenter device based on temperature control by means of heating and cooling an added liquid or gaseous solution, for energy-use optimization. The device makes it possible to utilize, for energy purposes, biomass and gases that result from anaerobic biodigestion in the thermophilic phase, said device differing from biodigesters currently offered in the market in that its temperature control is monitored, resulting in a shorter fermentation time, better quality, for energy-use purposes, of the produced dry material, and a high yield. The waste bio-fermenter has an elongate form and is built in a metallic structure comprising double partition lateral walls, sloping bottom to allow the solution runoff, and a ceiling with a hatchway. In the space between the partition walls heating of the liquid or gaseous solution placed therein occurs and then the heat present in the solution is transmitted to the internal cell. | 12-04-2014 |
20150010996 | CELL CULTURE DEVICE HAVING CULTURE MEDIUM REPLACEMENT FUNCTION - Provided is a small-scale cell culture apparatus having a culture medium replacement function for culturing cells in a small number of Petri dishes, the cell culture apparatus being capable of performing automatic replacement of the culture medium and cell culture within the same cavity and significantly reducing the apparatus cost. At least one set of upper and lower discs is arranged inside an incubator chamber | 01-08-2015 |
20150024479 | Thermal Cycling Apparatus and Method for Providing Thermal Uniformity - An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling. | 01-22-2015 |
20150037879 | THERMAL CYCLER AND THERMAL CYCLING METHOD - A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the rotational axis is shorter than the distance between the other end portion of the biotip and the rotational axis, a heating unit heats a first end portion of the biotip, a rotating unit rotates the holder, and a controller that controls the rotation speed of the rotating unit. The controller has a first mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes smaller than the gravity, and a second mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes greater than the gravity. | 02-05-2015 |
20150050725 | Laboratory Incubator Having Improved Moisture Distribution - The present invention relates to a laboratory incubator, more particularly, a gassing incubator, comprising an outer housing incorporating a door and an inner housing surrounding an internal chamber, which comprises a floor, a ceiling, three side walls and a lateral surface that is capable of being closed by said door or by an additional, inner door, and in which a flow channel is present, which comprises at least one air inlet opening in an end region and at least one air outlet opening in a different end region, wherein said at least one air outlet opening is formed such that effluent air is guided along at least one of the side walls and/or the lateral surface in the peripheral region of the internal chamber, and wherein a water reservoir capable of being heated is disposed within the flow channel such that air flowing in the flow channel is passed across or through said water reservoir. | 02-19-2015 |
20150056692 | Spouted Bed Bio-Reactor System - The invention describes a novel spouted bed bioreactor system (SBBS) for the removal of Benzene, Toluene, Ethyl-benzene, o-,m-,p-Xylene (BTEX) from a contaminated air stream. Organic-degrading bacteria, | 02-26-2015 |
20150314294 | SYSTEM AND METHODS FOR MAKING AND PROCESSING EMULSIONS - An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion. | 11-05-2015 |
20150328638 | INTEGRATED SYSTEM FOR PROCESSING MICROFLUIDIC SAMPLES, AND METHOD OF USING SAME - This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus. | 11-19-2015 |
20160010048 | CULTURE APPARATUS | 01-14-2016 |
20160010049 | CULTURE APPARATUS | 01-14-2016 |
20160017271 | CELL CULTURING DEVICE, CULTURING VESSEL, AND HOLDING VESSEL - In culture vessels for producing biological samples, it is possible to prevent decrease in a temperature at the time of taking out the culture vessels from an automatic culture apparatus and during delivery of the culture vessels which have been taken out from the automatic culture apparatus. This invention includes a culture vessel | 01-21-2016 |
20160108355 | SACCHARIFICATION REACTION APPARATUS - A saccharification-reaction apparatus includes: a reactor which causes a saccharification-reaction of a raw material; and a raw material charging device which charges the raw material into the reactor at a predetermined interval; the reactor includes: a heating steam feeder which increases a temperature of the raw material charged from the charging device to a saccharification-reaction temperature; and a feeding mechanism which sequentially feeds each of the charged raw materials toward an outlet-port in a predetermined short period of time while causing the saccharification-reaction of each raw material under a high temperature and pressure; the raw material charging-device charges into the reactor, the raw material with a suitable bulk density for a saccharification-reaction speed of the reactor; in this manner, the saccharification-reaction apparatus charges the raw material in a hydrolytic saccharification state into the reactor by the raw material charging device; and hydrolytically saccharifying the raw material efficiently in the reactor. | 04-21-2016 |
20160114327 | SYSTEM FOR THERMAL CYCLING OF MICROFLUIDIC SAMPLES - A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a thermal chuck in thermal communication with the heating element. The thermal chuck comprises a heating surface operable to make thermal contact with the microfluidic device. The heating surface is characterized by a temperature ramp rate between 2.5 degrees Celsius per second and 5.5 degrees Celsius per second and a temperature difference between a first portion of the heating surface supporting a first portion of the microfluidic device and a second portion of the heating surface supporting a second portion of the microfluidic device is less than 0.25° C. | 04-28-2016 |
20160160168 | INCUBATOR CONVEYING SYSTEM, INCUBATOR DEPOSITORY AND ISOLATOR SYSTEM - The present invention includes a conveyor body which partitions a plurality of storage chambers, a connection opening connected to an external device, and a conveying chamber that connects the plurality of storage chambers to the connection opening, a plurality of incubators detachably stored in the plurality of incubators, a conveyor device that conveys one of the plurality of incubators from the storage chamber to the connection opening, and an environment control device that individually controls an interior environment of the plurality of incubators by supplying and discharging gas to and from each incubator. | 06-09-2016 |
20160175843 | BIOCHEMICAL REACTOR | 06-23-2016 |
20160177248 | PIVOTING PRESSURIZED SINGLE USE BIOREACTOR | 06-23-2016 |
20160186122 | CULTURE APPARATUS - A culture apparatus that cultivates a culture, which includes an outer case, an inner case configured with metal plates inside the outer case, a heater outside the inner case, and a door, which opens/closes an opening formed in front faces of the inner cases, includes: shelf rests on which side parts of a bottom plate of a shelf are to be placed, the shelf rests formed by pressing on side plates of the inner case; and a heat transfer sheet attached to an outer surface of at least one of the side plates and configured to transfer heat of the heater to the inner case, the heat transfer sheet including slits, intermittently formed, to bend the sheet to depressions of the outer surface of the side plate at positions corresponding to the shelf rests, after the heat transfer sheet is attached to the outer surface. | 06-30-2016 |
20160194596 | Incubator Chamber | 07-07-2016 |
20160376540 | INCUBATION APPARATUS - An incubation apparatus, including a temperature-controlled room adjusted to be a predetermined environment condition, and incubating a sample of an incubation container inside the temperature-controlled room, includes a carrying apparatus, an imaging section, and an image analyzing section. The carrying apparatus carries the incubation container in the temperature-controlled room. The imaging section photographs a whole of the incubation container inside the temperature-controlled room. The image analyzing section analyses an operation state of the incubation apparatus or an incubating environment state of the sample based on a total observing image of the incubation container photographed at the imaging section, and outputs an error signal notifying an abnormality of the operation state or the incubating environment state in accordance with the analysis result. | 12-29-2016 |
20180024109 | Tissue Culture Tray and System for the In Vitro Testing and Characterization of Magnetically-Induced Rotation and Translational Motion of Magnetic Particles | 01-25-2018 |