Entries |
Document | Title | Date |
20080200519 | TETRAHYDRONAPHTHALENYLAMIDES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS - The present invention relates to the compounds of formula I, | 08-21-2008 |
20080207699 | Pyrazole Derivatives -
Compounds of the formula (I), in which R | 08-28-2008 |
20080221167 | Selective Insecticides Based on Haloalkylnicotinic Acid Derivatives, Anthranilic Acid Diamides, or Phthalic Acid Diamides and Safeners - The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising | 09-11-2008 |
20080221168 | N-Thio-Anthranilamid Compounds and Their Use as Pesticides - N-Thio-anthranilamid compounds of Formula (I) wherein is a group selected from A1 and A2 wherein the variables and the indices are as defined per the description, processes for preparing the compounds (I), pesticidal compositions comprising compounds (I), use of compounds (I) for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of Formula (I). | 09-11-2008 |
20080234328 | ACQUEOUS NEONICOTINOID COMPOSITIONS FOR SEED TREATMENT - An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one nitroimino- or nitroguanidino-compound in free form or in agrochemically useful salt form and a blend of the following components, by weight: | 09-25-2008 |
20080234329 | Carboxamide compounds and their use as calpain inhibitors - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. | 09-25-2008 |
20080234330 | Carboxamide compounds and their use as calpain inhibitors - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. | 09-25-2008 |
20080234331 | Synergistic Insecticidal Mixtures for the Treatment of Seed - The invention relates to insecticidal mixtures containing, as active substances, at least two compounds from the series of the chloronicotinyl insecticides, and to the use of these mixtures for promoting plant growth. | 09-25-2008 |
20080255204 | Agrochemical Formulation for Improving the Action and Plant Compatibility of Crop Protection Agents - The present invention relates to novel agrochemical formulations for treating plants, which formulations comprise, as cosolvent, propylene carbonate, and, if appropriate, further additives, to a process for preparing these formulations and to their use for treating plants and/or their habitat and for increasing the efficacy and plant compatibility of crop protection agents. | 10-16-2008 |
20080255205 | Multi-cyclic compounds and methods of use - The present invention relates to compounds of Formulas I and II, | 10-16-2008 |
20080262044 | Pesticidal Mixtures - The present invention relates to a synergistically effective pesticidal composition which comprises, on the one hand, a bisamide and, on the other hand, known fungicidal active ingredients and which is accordingly very well suited to controlling undesirable animal pests such as insects and acarids and also undesirable phytopathogenic fungi. | 10-23-2008 |
20080262045 | Metalloproteinase Inhibitors - Compounds of the formula (I) wherein Z is SO | 10-23-2008 |
20080269299 | Soil-Wetting Insecticide - A soil-applied composition for controlling turf-damaging pests is an aqueous solution including a neonicotinoid insecticide, such as an imidacloprid-based insecticide, and a nonionic surfactant. The composition may also include a bio-stimulant to aid in turf recovery, a humectant, or both a bio-stimulant and a humectant. An effective amount of the composition may be applied to a region of soil or turf in order to control turf-damaging pests, such as white grubs. | 10-30-2008 |
20080275092 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - The present invention relates to compounds having the formula, | 11-06-2008 |
20080280954 | Method of Improving Wakefulness - The present invention relates to the use of certain imidazolylalkyl-pyridines as wakefulness compounds. | 11-13-2008 |
20080306119 | Method for the Protection of Materials - The present invention relates to the use of the compound A) 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile(fludioxonil) as a microbicide for the protection of engineering or industrial materials, to mixtures containing such compound, and to the use of such mixtures for the protection of engineering or industrial materials. | 12-11-2008 |
20080306120 | Azaindole inhibitors of aurora kinases - The present invention relates to a compound represented by Formula (I): | 12-11-2008 |
20080312287 | Compound and Methods For the Treatment of Cancer and Malaria - Formula (I): Where R | 12-18-2008 |
20080312288 | SOLID FORMS OF 2-CHLORO-4-[1-(4-FLUORO-PHENYL)-2,5-DIMETHYL-1H-IMIDAZOL-4-YLETHYNYL]-PYRIDINE - The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine. | 12-18-2008 |
20080312289 | Use of Cni-Sl Formulations for Controlling White Fly - Method of controlling eggs and nymphal stages of whitefly by the spray application of agrochemical formulations containing at least one insecticide from the series of the neonicotinyls, at least one fatty alcohol ethoxylate of the formula (I), at least one solvent from the group consisting of dimethyl sulphoxide, N-methylpyrrolidone and butyrolactone, and, if appropriate, additives. | 12-18-2008 |
20080312290 | Oil Based Suspension Concentrates - Agrochemical formulation comprising at least one room-temperature-solid active substance from the class of the neonicotinoids, at least one room-temperature-solid active substance from the class of the pyrethroids, at least one penetrant, at least one vegetable oil, cyclohexanone, at least one nonionic surfactant and/or at least one anionic surfactant, and one or more additives, process for producing it, and its use for controlling harmful organisms. | 12-18-2008 |
20080319023 | Insecticidal Compositions for Control of General Household Pests - The present invention relates to an insecticidal composition comprising a pyrethroid and a second insecticide selected from the group consisting of imidacloprid, nithiazine, thiamethoxam, dinotefuran, nitenpyram, thiacloprid, clothianidin and chlorfenapyr, with significantly improved knockdown and mortality characteristics when applied to general household pests. | 12-25-2008 |
20090018171 | IMIDAZOLE DERIVATIVES - The present invention relates to imidazole derivatives of formula I | 01-15-2009 |
20090030045 | FACTOR XA INHIBITORS - The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample. | 01-29-2009 |
20090036497 | ECTOPARASITE CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of ectoparasites, preferably hematophageous ectoparasites, on an animal by administering to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, or an N-oxide, or a pharmaceutically or veterinarily acceptable salt thereof, | 02-05-2009 |
20090036498 | FLY CONTROL METHOD - This invention relates to a method of treating myiasis of an animal by applying to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, an N-oxide or a pharmaceutically or veterinarily acceptable salts salt thereof | 02-05-2009 |
20090036499 | FLY CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of flies on an animal by applying to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, (3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide), or an N-oxide, or a salt thereof, | 02-05-2009 |
20090048306 | PYRIDINE DERIVATIVES - The present invention relates to compounds of the formula (I): | 02-19-2009 |
20090054492 | Heterocyclyethylcarboxamide Derivatives - A compound of general formula (I): | 02-26-2009 |
20090069386 | Liquid Composition, Process for Producing the Liquid Composition,and Ectoparasite Controlling Agent for Use in Mammals and Avians - A liquid composition comprising (a) 21 to 70 parts by weight of a solvent having no nitrogen atom and having a carbonyl or sulfonyl group in the molecule, (b) 30 to 78.9 parts by weight of at least one component selected from the group consisting of a non-cyclic alcohol, an alkylene glycol, a polyalkylene glycol, a triol, a glycol monoacetate and a glycol monoalkyl ether, (c) 0.001 to 30 parts by weight of a physiologically active ingredient, and (d) 0.001 to 49 parts by weight of water. | 03-12-2009 |
20090076090 | Treated Expanded Polystyrene Foam - Expanded polystyrene coated with at least one organic pesticide, methods for making expanded polystyrene coated with at least one organic pesticide, and molded articles made from expanded polystyrene coated with at least one organic pesticide is provided herein. | 03-19-2009 |
20090076091 | INDAZOLE-HETEROARYL DERIVATIVES - The invention relates to novel indazole derivatives as cited in claim | 03-19-2009 |
20090076092 | METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS - Disclosed is a method for disrupting reproductive performance of an adult arthropod pest comprising contacting the adult arthropod pest or its environment with a sub-lethal, reproduction-disruptive amount of a carboxamide arthropodicide, its N-oxide, or a salt thereof. | 03-19-2009 |
20090111857 | 1,2,4-TRIAZOLE ETHER DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. | 04-30-2009 |
20090118335 | Acid Secretion Inhibitor - The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. | 05-07-2009 |
20090118336 | PYRAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS - The invention concerns pyrazole derivatives of Formula I | 05-07-2009 |
20090131483 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE - The invention provides compounds of formula (I) wherein R | 05-21-2009 |
20090131484 | PREVENTIVE OR REMEDY FOR BOWEL DISEASE - [Problem] To provide a preventive or a remedy for various diarrheas caused by inflammatory colitis, irritable bowel syndrome and other factors. | 05-21-2009 |
20090137637 | Tetrazolyl-Methylene Amino Acid Derivatives - This invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein R | 05-28-2009 |
20090143440 | Pyrazoles Useful in the Treatment of Inflammation - There is provided compounds of formula (I), wherein R | 06-04-2009 |
20090149506 | INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT - The present invention relates to increasing the activity of crop protection compositions comprising anthranilic acid diamides through the addition of ammonium salts and/or phosphonium salts or through the addition of ammonium or phosphonium salts and penetrants, to the corresponding compositions, to processes for preparing them and to their use in crop protection. | 06-11-2009 |
20090163554 | Use of CNI-OD Formulations for Controlling White Fly - Method of controlling eggs and nymphal stages of whitefly by the spray application of oil-based suspension concentrates containing at least one insecticide from the neonicotinyl series, at least one penetrant from the alcohol ethoxylate series, at least one vegetable oil, at least one nonionic surfactant and, if appropriate one or more additives. | 06-25-2009 |
20090176843 | SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS - A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1: | 07-09-2009 |
20090176844 | CARBOXAMIDES - Novel carboxamides of the formula (I) | 07-09-2009 |
20090182015 | MICROCAPSULE FORMULATIONS - A method of producing microcapsule formulations wherein slurries containing imidacloprid suspended in water-immiscible organic solvents are wet-crushed, then, urethane-based macromolecular polymers are added to this, and the resultant mixture is dispersed as liquid drops in water, to form membranes on the interfaces of the liquid drops. | 07-16-2009 |
20090186924 | SUBSTITUTED ARYLPYRAZOLES - This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides. | 07-23-2009 |
20090192198 | INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME - The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids. | 07-30-2009 |
20090203745 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF - The present invention relates to compounds of formula (I) wherein: A is a radical selected from the group comprising aromatic heterocyclic 5-membered ring systems; Ar is a radical selected from the group comprising optionally substituted 5- and 6-membered aromatic ring systems, whereby the ring system contains 0, 1, 2 or 3 heteroatoms selected from the group comprising N, O and S; Z is a linker and Ψ is a radical of formula (II) and their use for the inhibition of integrin. | 08-13-2009 |
20090203746 | Synergistic Insecticidal Composition Containing Chloronicotynyle and Pyrethroids Compounds - A synergistic insecticidal composition is formed containing a Chloronicotynyle compound and a Pyrethroids compound. The Chloronicotynyle compound is provided in an amount preferably ranging from 0.1 to 5.0% by weight of the synergistic insecticidal composition. The Pyrethroids compound is provided in an amount preferably ranging from 1 to 60% by weight of the synergistic insecticidal composition. The synergistic insecticidal composition also preferably includes 35 to 98.90% by weight of conventional agriculturally acceptable carrier(s) and/or excipients. | 08-13-2009 |
20090209597 | IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX - This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. | 08-20-2009 |
20090209598 | Resorcine Derivatives and Their Use as Pesticides - This invention relates to resorcine derivatives of formula (I) wherein R | 08-20-2009 |
20090215832 | Method of Combating Turf Pests With a Combination of Imidacloprid and Bifenthrin - This invention relates to a method of controlling surface insect pests of turf using bifenthrin and imidacloprid. | 08-27-2009 |
20090247586 | CARBOXAMIDES FOR CONTROLLING MICRO-ORGANISMS IN PLANT AND MATERIAL PROTECTION - Novel carboxamides of the formula (I) | 10-01-2009 |
20090247587 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVES - The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate. | 10-01-2009 |
20090253751 | HYDRAZIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR - Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided. | 10-08-2009 |
20090258910 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, lck, SAPK2α, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and FLT4 kinases. | 10-15-2009 |
20090270460 | FXR AGONISTS - Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. | 10-29-2009 |
20090270461 | Fungicide n-cycloalkyl-carboxamide, thiocarboxamide and n-substituted-carboximidamide derivatives - The present invention relates to N-cycloalkyl-carboxamide, N-cycloalkyl-thiocarboxamide and N-cycloalkyl-N-substituted carboximidamide derivatives of formula (I) wherein A represents carbo-linked, 5-membered heterocyclyl groups, T represents O, S, NR | 10-29-2009 |
20090270462 | 2-SULFANYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS - The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof. | 10-29-2009 |
20090275617 | Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds - Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) | 11-05-2009 |
20090286835 | NOVEL COMPOUNDS - The present invention provides compounds of formula (I) | 11-19-2009 |
20090291984 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE - The disclosure relates to a compound of formula (1): | 11-26-2009 |
20090298887 | METHOD FOR IMPROVING HARVESTED SEED QUALITY - The present invention is directed to a method for improving the quality of seeds harvested from seed-producing plants. The method comprises treating the pre-planted seeds of the seed-producing plants with a seed treatment insecticide and treating the resulting plant with foliar applications of a foliar insecticide; or treating the pre-planted seeds of the seed-producing plants with a seed treatment insecticide; or treating seed-producing plants with foliar applications of a foliar insecticide. | 12-03-2009 |
20090298888 | Method of improving plant development and increasing the resistance of plants to soil-borne harmful fungi - The present invention relates to a method of improving plant growth and increasing the resistance of plants to soil-borne harmful fungi by directly admixing neonicotinoid-containing formulations into nutrient solutions conventionally employed in raising plants. | 12-03-2009 |
20090306146 | Nicotinyls, Pyrethroids, and Ketoenols as a Gel Formation or Foam Formulation for Perennial Cultures - Method of controlling insects with a gel or foam formulation containing at least one insecticidal active substance, characterized in that the agrochemical formulation is applied externally to the trunk of the plant to be protected. | 12-10-2009 |
20090306147 | BIOLOGICAL EFFICACY OF AGROCHEMICAL COMPOSITIONS ON APPLICATION IN THE GROWTH SUBSTRATE SUITABLE FORMULATIONS AND USE THEREOF - In soil applications, the action of crop protection compositions comprising active compounds from the classes of the neonicotinoids, the pyrethroids, the butenolides, the ketoenols, the phenylpyrazoles or the fungicides can be improved by adjuvants. The present invention describes corresponding methods and suitable compositions. | 12-10-2009 |
20090312371 | SUBSTITUTED ARYLPYRAZOLES - This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents. | 12-17-2009 |
20090318505 | FUNGICIDAL COMPOSITIONS - A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of formula (I) or a tautomer of such a compound; and component (B) and component (C) are pesticides as described in claim | 12-24-2009 |
20090326012 | Malononitrile Compounds - Compounds of formula I wherein X is O or S(═O) | 12-31-2009 |
20100004293 | CRYSTALLINE FORMS OF ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS - The present invention provides novel crystals of Compound I, pharmaceutical compositions containing such novel form and a method of treating p38 kinase associated conditions, including rheumatoid arthritis, using such novel form. | 01-07-2010 |
20100010048 | Fungicide 2-pyridyl-methylene-carboxamide derivatives - The present invention relates to 2-pyridyl-methylene-carboxamide derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions: | 01-14-2010 |
20100010049 | Novel Tyrosinase inhibitors and pharmaceutical/cosmetic applications thereof - Compounds corresponding to the following general formula (I): | 01-14-2010 |
20100010050 | FORMULATIONS FOR THE CONTROLLED RELEASE OF AGROCHEMICAL ACTIVE AGENTS - There have been found novel compositions for the controlled release of agrochemical active substances, containing at least one agrochemical active substance, cellulose ester and calcium carbonate. | 01-14-2010 |
20100010051 | SUSPENSION CONCENTRATES - The present invention relates to novel suspension concentrates of certain agrochemically active compounds, to a process for preparing these formulations and to their use for applying the active comprised therein. | 01-14-2010 |
20100016373 | IMIDAZOLE CARBOXAMIDES - The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same. | 01-21-2010 |
20100022598 | Substituted inmidazoles as bombesin receptor subtype-3 modulators - Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes. | 01-28-2010 |
20100022599 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula: | 01-28-2010 |
20100035934 | PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS - This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. | 02-11-2010 |
20100035935 | ANTHRANILAMIDE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM - Anthranilamide compounds, a process for their production, and pesticides containing these compounds as active ingredients. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way. | 02-11-2010 |
20100041709 | SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The present invention relates to compounds corresponding to formula (I): | 02-18-2010 |
20100048638 | HEPARAN SULFATE INHIBITORS - Provided herein are heparan sulfate inhibitors, including modulators of heparan sulfate glycosylation, heparan sulfate sulfation, and/or heparan sulfate epimerization. | 02-25-2010 |
20100048639 | OXADIAZOLE DERIVATES AS S1P1 RECEPTOR AGONISTS - The present invention relates to novel oxadiazole compounds of formula (I) | 02-25-2010 |
20100048640 | HYDRAZIDE COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING AGENT CONTAINING THE SAME - Disclosed is a hydrazine compound represented by the formula (1) below, which has an excellent control activity against a harmful arthropod. (1) (In the formula, R | 02-25-2010 |
20100056582 | Modulators of LXR - Compounds of the invention, such as compounds of formula (I): | 03-04-2010 |
20100063105 | PHARMACEUTICAL USES AND SYNTHESIS OF NICOTINANILIDE-N-OXIDES - Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies. | 03-11-2010 |
20100063106 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME - Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs. | 03-11-2010 |
20100063107 | HYDROXY METHYL PHENYL PYRAZOLYL UREA COMPOUNDS USEFULL IN THE TREATMENT OF CANCER - The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide and alternative forms thereof (e.g., salts, solvates, hydrates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them; and methods for treating cancer using them. | 03-11-2010 |
20100069442 | PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. | 03-18-2010 |
20100076030 | METHODS OF TREATING RHEUMATOID ARTHRITIS - Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I: | 03-25-2010 |
20100087492 | SYSTEMIC TREATMENT OF BLOOD-SUCKING AND BLOOD-CONSUMING PARASITES BY ORAL ADMINISTRATION OF A PARASITICIDAL AGENT - Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies. | 04-08-2010 |
20100093808 | SALT AND POLYMORPH OF A DPP-IV INHIBITOR - The invention is concerned with (2S)-1-{[1,1-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile fumarate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV. | 04-15-2010 |
20100099717 | SUSPENSION CONCENTRATES FOR IMPROVING THE ROOT ABSORPTION OF AGROCHEMICAL ACTIVE INGREDIENTS - It is possible to increase the uptake of active compounds from crop protection compositions using suitable adjuvants, and thus to improve the action of crop protection agents. The present invention describes suitable adjuvants, methods and compositions. | 04-22-2010 |
20100113530 | S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA - Methods and compositions for treating, managing, and/or preventing cerebral malaria are disclosed. | 05-06-2010 |
20100120865 | Organic compounds - The present invention concerns a compound of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, wherein the groups Ri-Rs are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase. | 05-13-2010 |
20100120866 | PROCESS FOR PRODUCING AMIDE COMPOUND - There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (III): wherein R | 05-13-2010 |
20100120867 | METHOD OF TREATMENT - Improvements in the treatment of patients suffering from frequent heartburn are provided by a treatment regimen comprising administration of an effective daily amount of lansoprazole or a pharmaceutically acceptable salt thereof for up to 14 days. | 05-13-2010 |
20100130560 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES - The present invention relates 2-pyridyl-methylene-thiocarboxamide or 2-pyridyl-methylene-N-substituted-carboximidamide derivatives of formula (I) wherein A represents a carbo-linked 5-membered heterocyclyl group; T represents S, N—R | 05-27-2010 |
20100130561 | CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS - The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide. | 05-27-2010 |
20100137373 | PESTICIDAL COMPOSITION COMPRISING A STRIGOLACTONE DERIVATIVE AND AN INSECTICIDE COMPOUND - A composition comprising at least a strigolactone derivative (a) of general formula: | 06-03-2010 |
20100137374 | SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES - Disclosed is a solid arthropodicide composition comprising by weight
| 06-03-2010 |
20100144798 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 06-10-2010 |
20100152248 | ISCHEMIC DISORDER OR DISEASE INHIBITORS - The invention relates to the use of at least on inhibitor selected from the group consisting of raf-, protein kinase C(PKC)-, MEK1/2-, or ERK1/2-inhibitors, for the manufacturing of a medicament to be administrated from 1 up to 12 hours after initiation of an ischemic disease. | 06-17-2010 |
20100160383 | PYRAZOLE CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND ITS PREPARATION - A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an application for resisting cannabinoid CB1 receptor are provided. | 06-24-2010 |
20100160384 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS - Compounds of the formula I: | 06-24-2010 |
20100173949 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF - The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). | 07-08-2010 |
20100179196 | COMPOSITIONS AND METHODS FOR DEPLOYING A TRANSGENIC REFUGE AS A SEED BLEND - Methods and compositions for deploying refuge seeds together with transgenic crop seeds are provided. The refuge seeds can be non-transgenic seeds of a similar variety to that of the transgenic crop seeds, or the refuge seeds can be a transgenic variety. | 07-15-2010 |
20100197738 | FLY CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of flies on an animal by applying to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, (3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide), or an N-oxide, or a salt thereof, | 08-05-2010 |
20100204281 | ECTOPARASITE CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of ectoparasites, preferably hematophageous ectoparasites, on an animal by administering to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, or an N-oxide, or a pharmaceutically or veterinarily acceptable salt thereof, | 08-12-2010 |
20100210690 | N-(PYRAZOLE-3-YL)-BENZAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS - Novel heterocyclic compounds of the formula I | 08-19-2010 |
20100210691 | Compositions for the Control of Plant Pests - The present invention provides a composition comprising imidacloprid and metalaxyl. The compositions of the present invention find use as pesticides. | 08-19-2010 |
20100222393 | MUSCARINIC RECEPTOR ANTAGONISTS - Compounds of Formula (I), wherein represents a single bond when G is —OH and double bond when G is —O; R | 09-02-2010 |
20100222394 | METHOD FOR PRODUCING PYRAZOL-3-YL-BENZAMIDE DERIVATIVE - The present invention provides a more efficient industrial method for producing a pyrazol-3-yl-benzamide derivative expressed by a formula useful as medicine: | 09-02-2010 |
20100227893 | INSECTICIDE COMPOSITIONS - Insecticide compositions which comprise one or not less than two kinds of compounds being selected from a compound represented by the formula [I]: | 09-09-2010 |
20100249193 | Nematicidal, Insecticidal and Acaricidal Active Ingredient Combinations Comprising Pyridyl-ethylbenzamides and Insecticides - The present invention relates to novel active ingredient combinations which consist of fluopyram and further known active insecticidal ingredients, and are very suitable for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in seed treatment. | 09-30-2010 |
20100249194 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF - Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): | 09-30-2010 |
20100273833 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS - The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R | 10-28-2010 |
20100286211 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS - The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant | 11-11-2010 |
20100286212 | Treating and Preventing Viral Infections - Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using the compounds and their compositions in treating or preventing viral infections. | 11-11-2010 |
20100317700 | PESTICIDAL COMPOSITIONS - To provide a formulation composition which improves the controlling effect of an anthranilamide compound against pests. A pesticide composition which is a concentrated composition containing an anthranilamide compound as a pesticidal active ingredient, a dispersant and a hydrophilic organic solvent, characterized in that when the composition is diluted with water, the anthranilamide compound precipitates as solid particles in water. | 12-16-2010 |
20110003862 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases - Compounds of the formula (I), inhibit D-amino acid oxidase and hence find use in treating degenerative and psychiatric diseases. | 01-06-2011 |
20110015237 | SOLID COMPOSITION FOR PEST CONTROL - To provide an anthranilamide formulation compound for improving pest controlling effects. | 01-20-2011 |
20110021575 | PENETRATION ENHANCERS FOR INSECTICIDAL AGENTS - Polyalkylene oxide derivates of the formula (I), | 01-27-2011 |
20110034516 | AMINOPYRAZOLE DERIVATIVES - The invention relates to aminopyrazole derivatives of formula (I), | 02-10-2011 |
20110034517 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF - The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors. | 02-10-2011 |
20110046185 | Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof - The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs. | 02-24-2011 |
20110046186 | 1-Substituted Pyridyl-Pyrazolyl Amide Compounds and Uses Thereof - The present invention discoses a kind of 1-substituted pyridyl-pyrazolyl amide compounds and uses thereof. The compounds have structures as represented by the general formula I, wherein the definitions of each substituent showed in the specification. The compounds of formula I are novel and have excellent insecticidal and fungicidal activities and can be used for controlling insect pest and diseases. | 02-24-2011 |
20110060013 | THIAZOLES AND PYRAZOLES USEFUL AS KINASE INHIBITORS - The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention. | 03-10-2011 |
20110077274 | SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS - A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1: | 03-31-2011 |
20110086887 | Oil-Based Suspension Concentrates - The present invention relates to new, oil-based suspension concentrates of active agrochemicals, to a process for producing these formulations and to their use for applying the active substances comprised. | 04-14-2011 |
20110086888 | Fungicidally Active Compound Combinations - The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula | 04-14-2011 |
20110086889 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R | 04-14-2011 |
20110130427 | PESTICIDAL COMPOSITION - To improve the controlling effects of anthranilamide compounds against pests. A pesticidal composition comprising, as active ingredients, an anthranilamide compound or its salt, and a polyoxyalkylene phosphoric acid ester surfactant, and a method for controlling a pest by using such a composition, are provided. Further, a method for improving the pesticidal effects of an anthranilamide compound or its salt, as an active ingredient, by means of a polyoxyalkylene phosphoric acid ester surfactant, is provided. | 06-02-2011 |
20110136874 | FUNGICIDAL N-(2-PYRIDYLPROPYL) CARBOXAMIDE DERIVATIVES AND THEIR OXA, AZA AND THIA ANALOGUES - The present invention relates to fungicide N-(2-pyridylpropyl)carboxamide derivative and its oxa, aza and thia analogues of formula (I), their process of preparation and intermediate compound for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 06-09-2011 |
20110152325 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. | 06-23-2011 |
20110160250 | CRYSTALLINE FORMS OF A FACTOR XA INHIBITOR - The present invention provides crystalline forms of a mesylate salt of the compound 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide and pharmaceutical compositions and methods thereof. | 06-30-2011 |
20110178133 | CALCIUM RECEPTOR MODULATING AGENTS - The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I. | 07-21-2011 |
20110178134 | Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof - The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome. | 07-21-2011 |
20110178135 | SALTS AND CRYSTALLINE FORMS OF A FACTOR XA INHIBITOR - The present invention provides salts and crystalline forms of the compound 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide, and pharmaceutical compositions and method of use thereof. | 07-21-2011 |
20110201649 | AGRICULTURAL COMPOSITION - Provided is an agricultural composition comprising a compound represented by the formula (I) or a salt thereof or a hydrate thereof, for controlling a plant disease due to a plant pathogen: | 08-18-2011 |
20110201650 | CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF - A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof. | 08-18-2011 |
20110224262 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 09-15-2011 |
20110230525 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula: | 09-22-2011 |
20110257231 | ANTHRANILAMIDE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM - Anthranilamide compounds, a process for their production, and pesticides containing these compounds as active ingredients. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way. | 10-20-2011 |
20110263655 | METHOD FOR CONTROLLING INSECTS IN PLANTS - The invention relates to a method for controlling woolly apple aphid insect comprising contacting the insect or a locus, where control of the insect is desired, with a combination of at least one neonicotinoid compound and at least one benzoylphenyl urea compound. | 10-27-2011 |
20110269800 | P38 MAP KINASE INHIBITORS - There is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, including all tautomers thereof, compositions comprising the same, use of said compound and compositions for treatment, in particular for the treatment of asthma and COPD, and processes for the preparation of said compound. | 11-03-2011 |
20110306643 | TRIGLYCERIDE-CONTAINING DORMANCY SPRAYS - There is described a suspension concentrate, containing the following components:
| 12-15-2011 |
20110306644 | METALLOENZYME INHIBITOR COMPOUNDS - The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. | 12-15-2011 |
20110306645 | Novel ortho-substituted arylamide derivatives - The present invention relates to novel ortho-substituted arylamide derivatives of the general formula (I) | 12-15-2011 |
20110319452 | CYANO ANTHRANILAMIDE INSECTICIDES - This invention provides compounds of Formula 1, N-oxides and suitable salts thereof | 12-29-2011 |
20120010249 | Anthranilic diamide derivatives having cyclic side-chains - The present invention relates to novel anthranilic diamide derivatives of the general formula (I) | 01-12-2012 |
20120010250 | Anthranilamide derivatives as pesticides - The present invention relates to novel anthranilamide derivatives of the general formula (I) | 01-12-2012 |
20120010251 | PEST CONTROLLING COMPOSITION - The present invention provides a pest controlling composition comprising, as active ingredients, an amide compound of the formula (I) and a pyrethroid compound; and so on. | 01-12-2012 |
20120022112 | USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS - The present invention relates to the use of anthranilamide derivatives of the general formula (I) | 01-26-2012 |
20120035220 | Method of Fungal Pathogen Control in Grass or Turf - Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides. | 02-09-2012 |
20120035221 | Method of Fungal Pathogen Control in Grass or Turf - Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides. | 02-09-2012 |
20120035222 | Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyr- idine - The present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations. | 02-09-2012 |
20120071516 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity. | 03-22-2012 |
20120071517 | 2-PYRIDINYLETHYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES - The invention discloses a compound of general formula (I) | 03-22-2012 |
20120088795 | FACTOR XA INHIBITORS - The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample. | 04-12-2012 |
20120088796 | COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF - The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals. | 04-12-2012 |
20120095057 | PYRAZOLE COMPOUND - Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like. | 04-19-2012 |
20120101133 | PROCESS FOR PREPARING TETRAZOLE-SUBSTITUTED ANTHRANILAMIDE DERIVATIVES AND NOVEL CRYSTAL POLYMORPHS OF THESE DERIVATIVES - The present invention relates to a process for preparing tetrazole-substituted anthranilamide derivatives of the formula (I) | 04-26-2012 |
20120108639 | NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND - The present invention provides a compound having excellent regulating action on blood lipid level that is represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein, in one embodiment, A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; R | 05-03-2012 |
20120115911 | SEED INDEX SYSTEM FOR TREATING AGRICULTURAL SEEDS - Seed index system and methods for treating agricultural seeds with one or more seed care products employing a size-adjusted application rate based on the size of the seeds. Such size-adjusted application rates can be determined by a supplier of seed care products and communicated to an applicator who applies the seed care product to a quantity of seeds. Such size-adjusted application rates can be in the form of a chart, an equation, or a calculator. | 05-10-2012 |
20120129892 | NOVEL PHARMACEUTICALLY ACCEPTABLE SALTS OF 4-(1H-IMIDAZOL-4-YLMETHYL)PYRIDINE AND THEIR THERAPEUTICAL USES - The present invention concerns novel pharmaceutical compositions of immethridine, in particular of novel pharmaceutically acceptable salts thereof, such as the dioxalate salt of immethridine, as well as its therapeutical uses and novel process of preparation. | 05-24-2012 |
20120129893 | Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas - Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se. | 05-24-2012 |
20120136030 | COMBINATIONS OF MEK INHIBITORS AND RAF KINASE INHIBITORS AND USES THEREOF - This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-β. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders. | 05-31-2012 |
20120136031 | P38MAP KINASE INHIBITOR - The present invention relates to a compound of formula (I): | 05-31-2012 |
20120157500 | JAK INHIBITION BLOCKS RNA INTERFERENCE ASSOCIATED TOXICITIES - The instant invention provides a method for treating patients by administering a JAK inhibitor. The instant invention provides a method for treating patients by administering a JAK inhibitor wherein the JAK inhibitor is a JAK2 inhibitor. The instant invention provides a method for treating patients by administering a JAK inhibitor wherein the JAK inhibitor is selected from selected from Jak2-IA, AG490, Pyridone 6, WP1066, LS104, TG101209, TG101348, CP690,550, CP352,664, INCB18424, WHI-P154, CMP6, SB1518, XL019, CEP-701, INCB20, AUH-6-96 and AZ960. | 06-21-2012 |
20120184583 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 07-19-2012 |
20120196905 | SYNTHETIC COMPOUNDS AND METHODS TO DECREASE NICOTINE SELF-ADMINISTRATION - Methods and small molecule compounds for smoking and CNS disease harm reduction are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate or solvate thereof: | 08-02-2012 |
20120202853 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS - The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R | 08-09-2012 |
20120208853 | PEST CONTROL COMPOSITION - The present invention provides a pest control composition comprising, as active ingredients, an amide compound of the formula (I) [(I) where in R1 and R3 represent, for example, a C1-C6 alkyl group; R2 represent, for example, a Hydrogen atom, a C1-C6 alkyl group; R4 represent, for example, a halogen atom, a C1-C6 alkyl group; R5 represent, for example, a halogen atom, a cyano group; R6 and R7 represent, for example, a halogen atom] and pyriproxyfen; and so on. | 08-16-2012 |
20120214849 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula: | 08-23-2012 |
20120225910 | Substituted Heteroaryls - The present invention provides Formula (1A) compounds | 09-06-2012 |
20120232117 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME - The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis. | 09-13-2012 |
20120245204 | Unknown - Heteroarylpiperidine and -piperazine derivatives of the formula (I) | 09-27-2012 |
20120270906 | CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF - A method relieves both nociceptive pain and neuropathic pain and has fewer side effects. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof. | 10-25-2012 |
20120283298 | METHODS FOR TREATING MEMORY IMPAIRMENT - Methods for administering a therapeutically effective amount of a somatostatin receptor-4 (SSTR4) agonist in order to treat learning and memory impairment for Alzheimer's disease is disclosed. | 11-08-2012 |
20120289551 | MINERALOCORTICOID RECEPTOR ANTAGONISTS - Mineralocorticoid receptor antagonists, of which the following is exemplary. | 11-15-2012 |
20120302608 | Novel Imidazole Derivatives Useful for the Treatment of Arthritis - The present invention provides compounds of the formula below: | 11-29-2012 |
20120302609 | Pyrazolines for the Modulation of PKM2 - The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder. | 11-29-2012 |
20130005775 | METHODS OF TREATING ULCERATIVE COLITIS - Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed. | 01-03-2013 |
20130005776 | METALLOENZYME INHIBITOR COMPOUNDS - The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. | 01-03-2013 |
20130040995 | NOVEL COMPOUNDS - There is provided inter alia a compound of formula (I): | 02-14-2013 |
20130053419 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS - Compounds which are sulfonamido 3,4-diarylpyrazole derivatives, or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is their use as prodrugs. | 02-28-2013 |
20130065928 | BIOMARKERS FOR PI3K-DRIVEN CANCER - Disclosed is the discovery that the mTORC2 complex plays a role in the regulation of PKN3 phosphorylation at the turn motif threonine; and the use of the phosphorylation status of the turn motif threonine of PKN3 as a biomarker. In some embodiments, the phosphorylation status of the turn motif threonine of PKN3 is determined using an antibody that specifically binds to the turn motif threonine of a PKN3 protein, such as an anti-phosphoT860 antibody. In some embodiments, the invention relates to methods for screening compounds that have cancer therapeutic potential, methods for diagnosing cancer, methods for determining the prognosis of a patient suffering from cancer, methods for stratifying patients in a clinical trial, methods for treating a patient suffering from cancer, and methods for determining the effectiveness of a particular treatment regimen. | 03-14-2013 |
20130072525 | NITRATE AND DIAZENIUMDIOLATE DERIVATIVES OF PIOGLITAZONE - Nitrate ester and diazeniumdiolate derivatives of pioglitazone are described. They have valuable properties in the treatment of vascular and metabolic diseases, for example type 2 diabetes. | 03-21-2013 |
20130079375 | MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES - Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D | 03-28-2013 |
20130085164 | Imidazole Derivatives - The present application provides novel imidazole compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer. | 04-04-2013 |
20130109723 | PESTICIDAL COMPOSITION AND ITS USE | 05-02-2013 |
20130123306 | Inhibition of Mitogen-activated Protein Kinases in Cardiovascular Disease - The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic material with a mitogen-activated protein kinase (MAPK) pathway inhibitor. The present invention further relates to vascular devices comprising a MAPK pathway inhibitor. | 05-16-2013 |
20130131119 | N-[(HET)ARYLETHYL)] PYRAZOLE(THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES - The present invention relates to fungicidal N-[(het)arylethyl)] pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogues, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 05-23-2013 |
20130131120 | THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR NEUROPATHIC PAIN - A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which agent does not produce any new side effects on the central nervous system. The therapeutic agent or a prophylactic agent for neuropathic pain includes as effective ingredients a cyclohexane derivative, represented by the following formula, or a pharmaceutically acceptable salt thereof or a prodrug thereof, and a calcium channel α2δ ligand. | 05-23-2013 |
20130143929 | FUNGICIDAL IMIDAZOLES - Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, | 06-06-2013 |
20130190362 | ARTHROPODICIDAL ANTHRANILAMIDES - This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof | 07-25-2013 |
20130190363 | THERAPEUTIC AGENT FOR NEUROLOGICAL DISEASES - An object of the present invention is to provide a pharmaceutical agent useful for treating and preventing neurological disease, having satisfactory solubility and oxidative stress-mediated cell death suppressive activity as well as capable of exhibiting excellent blood-brain barrier permeability. The present invention is directed to an acylaminoimidazole derivative represented by general formula (I) or a salt thereof, and a pharmaceutical and a therapeutic or preventive agent for neurological disease containing the same, as an active ingredient. | 07-25-2013 |
20130190364 | PEST CONTROLLING COMPOSITION AND METHOD FOR CONTROLLING PEST - The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more diamide compound(s) selected from Group (A) shows an excellent controlling activity on a pest. Group (A): a group consisting of a compound of Formula (2): wherein a combination of R | 07-25-2013 |
20130197037 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITOR - The present invention relates to a compound of formula (I): | 08-01-2013 |
20130203818 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity. | 08-08-2013 |
20130203819 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS - The present invention relates to compounds of Formula (I): | 08-08-2013 |
20130210863 | SYNERGISTIC INSECTICIDAL MIXTURES - The present invention relates to synergistic insecticidal mixtures comprising a) a Pyrethroid insecticide (preferably bifenthrin), b) a Neonicotinoid insecticide (preferably imidacloprid) and c) a Benzoylphenyl urea insecticide (preferably novaluron) and to the related compositions and methods of controlling insects. | 08-15-2013 |
20130210864 | N-BENZYL HETEROCYCLIC CARBOXAMIDES - The present invention relates to N-benzyl heterocyclic carboxamides derivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 08-15-2013 |
20130225638 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF - Disclosed are imidazole derivatives as represented by formula (I), and preparation method and use thereof. The compounds can inhibit cyclooxygenase and treat diseases mediated by cyclooxygenase. | 08-29-2013 |
20130253011 | INSECTICIDAL COMPOUNDS - The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests wherein A | 09-26-2013 |
20130253012 | Pyrazole Compounds for Controlling Invertebrate Pests - The present invention relates to a method for controlling invertebrate pests, in particular arthropod pests and nematodes, by using pyrazole compounds of formula I and the salts thereof, the tautomers thereof, the N-oxides thereof and the salts of the tautomers or N-oxides thereof, | 09-26-2013 |
20130289078 | CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS - The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide. | 10-31-2013 |
20130324579 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS - The present invention relates to pyrazole and imidazole derivatives of formula (I) wherein U, V, L, X, Y, R | 12-05-2013 |
20130331417 | INSECTICIDAL MIXTURES WITH IMPROVED PROPERTIES - The present invention relates to novel pesticidal compositions comprising the crystalline modification I of 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino} furan-2(5H)-one and a insecticide, acaricide or nematicide that show surprisingly good insecticidal, acaricidal, nematicidal and fungicidal activities. In particular, these compositions are suited for the treatment of seed. | 12-12-2013 |
20140005231 | FUNGICIDAL HETEROCYCLIC CARBOXAMIDES | 01-02-2014 |
20140018396 | COMBINATION OF SULFONAMIDE COMPOUND - The object of the present invention is to discover a combination of preventive or therapeutic drugs for glaucoma or ocular hypertension, which is useful as a preventive or therapeutic agent for glaucoma or ocular hypertension. By combining isopropyl(6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate with other preventive or therapeutic drug for glaucoma or ocular hypertension, their intraocular pressure lowering effects are complemented and/or enhanced each other. As for the administration form, these drugs may be administered concomitantly or may be administered as a combination drug. | 01-16-2014 |
20140045901 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF - Disclosed are imidazole derivatives as represented by formula (I), and preparation method and use thereof. The compounds can inhibit cyclooxygenase and treat diseases mediated by cyclooxygenase. | 02-13-2014 |
20140051729 | COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS - Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. Embodiments of the methods disclosed herein include administering therapeutically effective amounts to subjects suffering from a degenerative muscle condition, such as, for example, subjects suffering from sarcopenia and subjects suffering from muscular dystrophy, including subjects suffering from Duchenne Muscular Dystrophy and Becker Muscular Dystrophy. | 02-20-2014 |
20140088152 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE - The present invention provides a composition comprising a pyrazole derivative compound and a pharmaceutically acceptable salt thereof. The composition is remarkably effective for preventing and treating cardiovascular diseases. | 03-27-2014 |
20140088153 | N-(3-CARBAMOYLPHENLY)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF FOR CONTROLLING ANIMAL PESTS - The invention relates to compounds of the general formula (I) | 03-27-2014 |
20140107162 | COMPOSITIONS AND METHODS FOR CONTROLLING PESTICIDE RESISTANT PESTS - Provided are compositions comprising (i) a neonicotinoid; and (ii) a compound of formula (I) or (II), preferably wherein the composition is a pesticide composition, for example an insecticide composition. Also provided is use of a compound of formula (I) or (II) as a neonicotinoid synergist and use of a compound of formula (I) or (II) in combination with a neonicotinoid. Further provided are methods for controlling pests. | 04-17-2014 |
20140128434 | METHOD OF ADMINISTRATION AND TREATMENT - This invention relates to a method of treating cancer in a human in need thereof by determining the presence or absence of a detectable amount of a gene product of the Neurofibromin-2 (NF2) gene in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. This invention also relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a functional isoform 1 protein of the NF2 gene, or a functional fragment thereof, in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. | 05-08-2014 |
20140128435 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS - The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R | 05-08-2014 |
20140142143 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands - The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions. | 05-22-2014 |
20140142144 | Oxazolidinone Compounds and Their Uses in Preparation of Antibiotics - The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by Formula I. The oxazolidinone compounds of the invention, which are new compounds obtained through numerous screening, have significant antibacterial activity against bacteria such as drug-resistant | 05-22-2014 |
20140155436 | CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES - The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly. | 06-05-2014 |
20140163075 | MODULATION OF THE UBIQUITIN-PROTEASOME SYSTEM (UPS) - The invention relates to the field of 26S proteasome inhibition, activation and modulation and to identify compounds which activate 26S proteasome in live cells and a method of treating autoimmune diseases, cancer, inflammation and neurogenerative disorders by inhibition, activation and modulation of the 26S proteasome. | 06-12-2014 |
20140163076 | Use of Active Substance Combinations Having Insecticidal Properties for Controlling Animal Pests from the Stink Bug Family - The present invention relates to the use of active substance combinations which consist firstly of known cyclic ketoenols and secondly of further known insecticidal active substances, for controlling animal pests from the stink bug family (Pentatomidae). | 06-12-2014 |
20140171469 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 06-19-2014 |
20140194473 | IMIDAZOLE FUNGICIDES - Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, | 07-10-2014 |
20140221432 | COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ARTHROPODS - The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising an amide compound represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of neonicotinoid compounds selected from the group (A) consisting of imidacloprid, clothianidin, thiamethoxiam, dinotefuran, acetamiprid, thiacloprid and nitenpyram, shows an excellent controlling efficacy on harmful arthropods. | 08-07-2014 |
20140243376 | O-AMINO BENZONITRILE COMPOUNDS, METHOD FOR PREPARING SAME AND USES THEREOF - It relates to an anthranilonitrile compound, and to the process for preparing the said anthranilonitrile compound, and to its use. The anthranilonitrile compound has a chemical general formula (I). The compound of the general formula (I) has excellent pesticidal activity, can be used to control pests, and has more than 98% of mortality in 3 days to diamondback moth and pink borer. | 08-28-2014 |
20140249187 | COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ARTHROPODS - The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising an carboxylic acid represented by a formula (I) wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of pyrazole compounds selected from the group (A) consisting of chlorantraniliprole, cyantraniliprole and a compound represented by a formula (II), shows an excellent controlling efficacy on harmful arthropods. | 09-04-2014 |
20140256771 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity. | 09-11-2014 |
20140275176 | Compounds and uses thereof for the modulation of hemoglobin - Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation. | 09-18-2014 |
20140275177 | COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ARTHROPODS - The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising an amide represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of pyrazole compounds selected from the group (A) consisting of chlorantraniliprole, cyantraniliprole and a compound represented by a formula (II), shows an excellent controlling efficacy on harmful arthropods. | 09-18-2014 |
20140288128 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described. | 09-25-2014 |
20140288129 | PRMT1 INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described. | 09-25-2014 |
20140288130 | COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ARTHROPODS - The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising an amide represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of pyrazole compounds selected from the group (A) consisting of chlorantraniliprole, cyantraniliprole and a compound represented by a formula (II), shows an excellent controlling efficacy on harmful arthropods. | 09-25-2014 |
20140288131 | COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ARTHROPODS - The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful anthropods. A composition for controlling harmful arthropods comprising an amide represented by a formula (I) wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of pyrazole compounds selected from the group (A) consisting of chlorantraniliprole, cyantraniliprole and a compound represented by a formula (II), shows an excellent controlling efficacy on harmful arthropods. | 09-25-2014 |
20140296297 | Materials Having Embedded Insecticides and Additives - The present invention concerns polymeric material containing at least an embedded insecticidally active ingredient and an additive, which are released at room temperature. It similarly concerns materials produced from this polymer, for example in the form of self-supporting film/sheet, threads, wovens, fabrics, textiles, nets, curtains and pellets. The invention further concerns processes for producing such polymeric material and also the use of the self-supporting film/sheet, threads, wovens, fabrics, textiles and nets and curtains produced from the material for protecting humans, animals and plants and buildings, machines and packaging against arthropods, particularly for controlling insects. | 10-02-2014 |
20140296298 | COMPOSITION AND METHOD FOR CONTROLLING HARMFUL ARTHROPODS - The present invention provides a composition for controlling harmful arthropods having an excellent controlling harmful arthropods comprising an amide represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of pyrazole compounds selected from the group (A) consisting of chlorantraniliprole, cyantraniliprole and a compound represented by a formula (II), shows an excellent controlling efficacy on harmful arthropods. | 10-02-2014 |
20140303212 | METHOD FOR TREATING NEURODEGENERATION USING A p38MAPK INHIBITOR - Ataxia-telangiectasia (A-T) is a progressive degenerative disorder that results in major neurological disability. In A-T patients, necropsy has revealed atrophy of all cerebellar cortical layers with extensive Purkinje and granular cell loss. We have previously identified an increase in phospho-p38MAPK levels, which was accompanied by downregulation of Bmi-1 and upregulation of p21, as key components of the mechanism causing defective proliferation of neural stem cells (NSCs) isolated from subventricular zone (SVZ) of Atm-null mice. Our results demonstrate that restoration of NSCs by pharmacologic inhibition of p38MAPK signaling has the potential to treat neurological defects of A-T. This study provides new insights into the therapeutic strategy targeting NSCs rather than replacing impaired neurons not only for A-T, but for other neurodegenerative disorders as well. | 10-09-2014 |
20140309262 | ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES - Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. | 10-16-2014 |
20140315957 | ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention relates to novel substituted thioimidazolidinone compounds and pharmaceutical compositions comprising such compounds for treatment of androgen receptor-associated diseases or disorders, such as prostate cancer, benign prostatic hypertrophy, male hair loss, muscle loss, acne and hirsutism. | 10-23-2014 |
20140329864 | Crystalline salts of R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid - The invention relates to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid which is in a crystalline form or in at least partially crystalline form as a monohydrate or anhydrate, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). | 11-06-2014 |
20140329865 | Pesticidal Mixtures - The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) wherein B | 11-06-2014 |
20140336225 | KINASE MODULATORS FOR THE TREATMENT OF CANCER - Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines. | 11-13-2014 |
20140336226 | Salt Of (R)-3-(6-Amino-Pyridin-3-Yl)-2-(1-Cyclohexyl-1H-Imidazol-4-Yl) Ethyl Propionate - The invention relates to the salt of naphthalene-1,5-disulfonic acid with (R)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)ethyl propionate, which can be represented by the following structural formula of formula (I), to methods for the production thereof, to drugs containing said salt, and to the use of said drugs to treat diseases that are accompanied by thromboses, embolisms, hypercoagulability, or fibrotic changes. | 11-13-2014 |
20140343106 | Sodium Salt Of (R)-3-[6-Amino-Pyridin-3-Yl]-2-(1-Cyclohexyl-1H-Imidazol-4-Yl)-Propionic Acid - The invention relates to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid, and to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). | 11-20-2014 |
20140364458 | USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT - A composition comprising a compound of formula (I): | 12-11-2014 |
20150011592 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands - The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions. | 01-08-2015 |
20150025116 | PROCESS FOR PREPARING TETRAZOLE-SUBSTITUTED ANTHRANILAMIDE DERIVATIVES AND NOVEL CRYSTAL POLYMORPHS OF THESE DERIVATIVES - The present invention relates to a process for preparing tetrazole-substituted anthranilamide derivatives of the formula (I) | 01-22-2015 |
20150057315 | Methods for Treatment of 16P11.2 Microdeletion Syndrome - Subjects that have a 16p11.2 microdeletion syndrome are treated by administering compositions that include mGluR inhibitors, including mGluR antagonists that include mGluR negative allosteric modulators. Administration of compositions employed in the methods of the invention can treat psychiatric, including neuropsychiatric disorders, cognitive impairments, attention, obesity, intellectual disability and seizure disorders. | 02-26-2015 |
20150094342 | DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME - The invention relates to diaminoaryl derivatives substituted by carbamate, salts thereof and a pesticidal composition containing the same, which exhibit superior pest control effects against various insect pests of insect species, in particular against moths such as the diamondback moth or | 04-02-2015 |
20150105430 | METHODS OF TREATING OR PREVENTING NEUROPATHIC PAIN - A method treats or prevents neuropathic pain with a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which agent does not produce any new side effects on the central nervous system. The therapeutic agent or a prophylactic agent used in the method includes as effective ingredients a cyclohexane derivative or a pharmaceutically acceptable salt thereof or a prodrug thereof, and a calcium channel α2δ ligand. | 04-16-2015 |
20150111925 | SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS - The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel. | 04-23-2015 |
20150111926 | SYNERGISTIC PESTICIDAL COMPOSITIONS AND RELATED METHODS - A pesticidal composition comprises a synergistically effective amount of an ecdysone receptor agonist compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio)propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by insects comprises contacting the plant with the synergistic pesticidal composition. | 04-23-2015 |
20150133506 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF - Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): | 05-14-2015 |
20150141465 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN - Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation. | 05-21-2015 |
20150148381 | SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES - The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing. | 05-28-2015 |
20150289502 | PENETRANTS FOR AGROCHEMICAL FORMULATIONS - An agrochemical formulation comprising a penetrant and an agrochemical active. The penetrant is an esterified and/or etherified polyol alkoxylate obtainable by directly esterifying and/or etherifying a polyol alkoxylate. There is also provided a method of making the penetrant comprising alkoxylation of a polyol, and esterification or etherification of the formed poyol alkoxylate. The penetrant is suitable for use in agrochemical formulations to enhance penetration of the active across a leaf cuticle. | 10-15-2015 |
20150299120 | Spirohydantoin compounds and their use as selective androgen receptor modulators - The present invention relates to a compound of formula (I-1) in free form or in pharmaceutically acceptable salt form | 10-22-2015 |
20150335625 | PYRIDONYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF - The invention provides pyridonyl guanidine compounds that inhibit F | 11-26-2015 |
20150351400 | Processes for the Preparation of Pesticidal Compounds - The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds. | 12-10-2015 |
20150351402 | NOVEL MICROBIOCIDES - Compounds of formula (I) wherein the other substituents MBG, HetAr, R | 12-10-2015 |
20150376163 | Anthranilamide Compounds, Their Mixtures and the Use Thereof as Pesticides - Compounds of formula (I) | 12-31-2015 |
20160016942 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS C-FMS KINASE INHIBITORS - The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives. | 01-21-2016 |
20160029637 | TERMITICIDE COMPOSITION AND METHODS FOR TREATING TERMITES - A termiticide concentrate comprising a termiticide composition comprising a phenylpyrazole, such as fipronil and a neonicotinoid, such as imidacloprid, wherein the composition is dispersed in an aqueous medium to form the termiticide concentrate. The concentrate containing the combination of active termiticides provides an increased efficacy not exhibited by either active when used alone. | 02-04-2016 |
20160029638 | SPOT-ON PESTICIDE COMPOSITION COMPRISING A NEONICOTINOID AND A PYRETHROID - A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of active components, the active components being a combination of a neonicotinoid and a pyrethroid, and optionally comprising an insect growth regulator, in doses and proportions which are parasiticidally effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area. | 02-04-2016 |
20160031863 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF - Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. | 02-04-2016 |
20160046585 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN - There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin. | 02-18-2016 |
20160067234 | PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX - Phenyl triazole derivative (specifically, 1-[6-[[5-(2-fluorophenyl)-3-methyl-triazol-4-yl]methoxy]-3-pyridyl]imidazole-4-carbonitrile or a pharmaceutically acceptable salt thereof), pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound is in particular considered useful for the treatment of central nervous system diseases and disorders which are responsive to modulation of GABA | 03-10-2016 |
20160075691 | 4,5- DIHYDROPYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY - The present invention relates to 4,5-dihydropyrazole derivatives of the formula (I) | 03-17-2016 |
20160095841 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK - The present invention relates to a compound of formula (I): | 04-07-2016 |
20160115152 | Novel Compounds - There is provided inter alia a compound of formula (I): | 04-28-2016 |
20160122305 | Topical Compositions and Methods of Use Thereof - The invention is generally directed to compositions useful for improving the aesthetic appearance of human skin and the use of those compounds for improving the appearance of human skin, including improving skin tone, reducing the appearance of dark circles under the eyes, and reducing inflammation in the skin. The compositions typically comprise adrenergic receptor agonists. | 05-05-2016 |
20160122334 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 05-05-2016 |
20160128330 | Stable Suspension Concentrate Formulation for Water-Soluble Compounds - The present invention is directed to an insecticidal water based suspension concentrate formulation comprising a water-soluble insecticide selected from the group consisting of N-cyanomethyl-4-(trifluoromethyl)nicotinamide and (EZ)-1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylidineamine and at least one water-soluble salt selected from the group consisting of magnesium sulfate (hydrated and anhydrous forms) and sodium sulfate, wherein the water-soluble insecticide is present in an insecticidally effective amount and methods of use. | 05-12-2016 |
20160130248 | (+)-5-(3,4-DIFLUOROPHENYL)-5-[(3-METHYL-2-OXOPYRIDIN-1(2H)-YL)METHYL]IMIDA- ZOLIDINE-2,4-DIONE AND DRUG CONTAINING SAME - Provided is (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imidazolidine-2,4-dione or a salt thereof. Also provided is a drug containing as the active ingredient (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imidazolidine-2,4-dione or a salt thereof. | 05-12-2016 |
20160152602 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | 06-02-2016 |
20160166556 | METHODS OF TREATING PULMONARY HYPERTENSION | 06-16-2016 |
20160174556 | DERMAL COMPOSITIONS | 06-23-2016 |
20160174559 | ARTHROPOD PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS | 06-23-2016 |
20160198703 | A NOVEL AQUEOUS SUSPOEMULSION AND A PROCESS FOR PREPARING THE SAME | 07-14-2016 |
20190144418 | POLYMORPH OF BENZAMIDE COMPOUND AND PREPARATION METHOD AND APPLICATIONS THEREOF | 05-16-2019 |
20220135553 | KCNT1 INHIBITORS AND METHODS OF USE - The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein. | 05-05-2022 |