Entries |
Document | Title | Date |
20080200518 | Substituted Cyclic Urea Derivatives - Certain novel phenyl substituted cyclic urea derivatives have unexpected insecticidal activity. These compounds are represented by formula I: where A, B a, D, b, E, G, c, d, J, X and R through R | 08-21-2008 |
20080214621 | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 - The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention compositions containing these compounds for the treatment of metabolic syndrome, diabetes, hyperglycemia obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula I wherein G | 09-04-2008 |
20080214622 | Substituted Triazole Derivatives As Oxytocin Antagonists - The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.). | 09-04-2008 |
20080214623 | N-(2,2-Dimethylpropyl)-6- -3-Pyridinecarboxamide - The present invention relates to a novel compound, processes for its preparation, compositions comprising the same and its use in the treatment of condition or diseases mediated by p38 kinase activity. | 09-04-2008 |
20080227824 | 5-(Phenylisoxazolylethoxy) - Triazol- 3 -Yl Substituted Pyridine Compounds for the Treatment of Neurological, Psychiatric or Pain Disorders - The present invention is directed to novel compounds of formula (I)/(II)/(III), their use in therapy and pharmaceutical compositions comprising said novel compounds. | 09-18-2008 |
20080242704 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors - The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Fit-3 inhibitors. | 10-02-2008 |
20080249135 | COMPOUNDS FOR ALZHEIMER'S DISEASE - The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH | 10-09-2008 |
20080255202 | Phenylthioacetic Acid Derivatives and Use Thereof - The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis. | 10-16-2008 |
20080255203 | HETEROCYCLIC COMPOUNDS AND THEIR METHODS OF USE - The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof. | 10-16-2008 |
20080287505 | SUBSTITUTED 2-METHYL-2-PHENOXY-N-PROPYL-PROPIONAMIDES AS CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING OBESITY - The present invention provides novel substituted 2-methyl-2-phenoxy-N-propyl-propionamides and derivatives thereof that are useful as cannabinoid receptor antagonists/inverse agonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders. | 11-20-2008 |
20080293775 | Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease - The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory-disorders, pharmaceutical compositions containing them, and processes for their preparation. | 11-27-2008 |
20080312286 | Indanone Potentiators of Metabotropic Glutamate Receptors - The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. | 12-18-2008 |
20090048305 | Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections - The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: | 02-19-2009 |
20090054491 | Use - The present invention relates to the use of compounds of formula II for the treatment or prevention of obesity. | 02-26-2009 |
20090062349 | 1-Hydroxycycloalkanecarboxamide derivatives - α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R | 03-05-2009 |
20090069385 | Antidiabetic Oxazolidinediones and Thiazolidinediones - Pyridinyloxyphenyl and pyridinyloxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes. | 03-12-2009 |
20090093523 | Tetrazole-substituted aryl amide derivatives and uses thereof - Compounds of the formula: | 04-09-2009 |
20090093524 | COMPOUNDS AND METHODS FOR MODULATING FXR - Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. | 04-09-2009 |
20090105307 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS - The invention relates to compounds of formula | 04-23-2009 |
20090124665 | Potassium Channel Inhibitors - The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. | 05-14-2009 |
20090124666 | TRPV1 ANTAGONISTS - Compounds of formula (I) | 05-14-2009 |
20090137636 | Reverse Isoxazoles - The present invention relates to polycyclic compounds, processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. | 05-28-2009 |
20090156643 | Substituted isoxazoline compound and pesticide - There is provided a novel pesticide, particularly an insecticide or an acaricide. A substituted isoxazoline compound of formula (1) or a salt thereof: | 06-18-2009 |
20090170907 | Chemical Compounds - This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. | 07-02-2009 |
20090176842 | SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS - The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses. | 07-09-2009 |
20090192197 | NOVEL OXAZOLIDINONE DERIVATIVES - The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as | 07-30-2009 |
20090203744 | NOVEL PYRIDINE DERIVATIVES - The present invention relates to novel pyridine derivatives of the formula (I), their stereoisomers, and their pharmaceutically acceptable salts, and compositions. The present invention more particularly provides novel pyridine derivatives of the general formula (I). | 08-13-2009 |
20090209596 | Oxazole Hydroxamic Acid Derivatives and Use Thereof - Provided are an oxazole hydroxamic acid derivative and a pharmaceutically useful salt thereof as a histone deacetylase inhibitor The oxazole hydroxamic acid derivative and pharmaceutically useful salt thereof, prepared in accordance with the present invention, can treat and/or prevent various cancers and inflammatory diseases caused by histone deacetylase. | 08-20-2009 |
20090286834 | Pyridine Analogues VI - The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y | 11-19-2009 |
20090306145 | Pyridylisoxazole Derivatives - This invention offers isoxazole derivatives represented by the following formula (I) | 12-10-2009 |
20090312370 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS - The invention relates to novel macrocyclic compounds of the formula | 12-17-2009 |
20100004292 | Iminooxazolidine Derivatives and Their Use - The present application relates to novel iminooxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders. | 01-07-2010 |
20100022597 | 2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11BETA-HSD1 INHIBITORS - The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions. | 01-28-2010 |
20100041705 | Organic Compounds - The present invention provides a compound of formula (I): | 02-18-2010 |
20100041706 | Compounds 501 - The present invention relates to a novel crystalline form of 4-(5-{( | 02-18-2010 |
20100041707 | INHIBITORS OF ION CHANNELS - Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel. | 02-18-2010 |
20100041708 | N-PHENYLARYLSULFONAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND AS ACTIVE INGREDIENT, SYNTHETIC INTERMEDIATE FOR THE COMPOUND AND PROCESS FOR IT'S PREPARATION - An N-phenylarylsulfonylamide compound of formula (I) | 02-18-2010 |
20100056581 | Substituted Piperidino Phenyloxazolidinones - The present invention relates to certain substituted piperidino phenyloxazolidinones. Specifically, the invention relates to geminally disubstituted piperidino phenyloxazolidinones having antimicrobial activity with improved pharmacokinetic profile. The invention also relates to processes for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating or preventing microbial infections using the compounds of the present invention. | 03-04-2010 |
20100063104 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF - It is intended to provide a compound represented by the formula (I): | 03-11-2010 |
20100076028 | Design and Synthesis of Novel Antimicrobials - The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups. | 03-25-2010 |
20100076029 | Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 03-25-2010 |
20100087491 | POLYCYCLIC COMPOUNDS - The invention relates to novel diaryl oxadiazole compounds of Formula I: | 04-08-2010 |
20100099716 | CETP INHIBITORS - Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: | 04-22-2010 |
20100113529 | DOSAGE REGIMEN FOR COMT INHIBITORS - The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders, wherein said medicament is administered according to a dosing regimen having a dosing periodicity ranging from about twice a day to about once every other day. | 05-06-2010 |
20100120864 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS - The invention relates to compounds of formula I | 05-13-2010 |
20100130559 | NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE - The present invention relates to a compound represented by formula (I), which has a GPR120 agonist action and thus is useful for treatment of diabetes mellitus or hyperlipidemia, or a pharmaceutically acceptable salt thereof. In the formula, (AA) represents a phenyl or the like, which may be substituted with a lower alkoxy group or the like; (BB) represents a divalent group or the like, derived by removal of two hydrogen atoms from a benzene which may be substituted with a halogen atom or the like; X represents a spacer having a main chain composed of 1-8 carbon atoms wherein 1-3 carbon atoms in the main chain may be substituted with an oxygen atom or the like; and Y represents a hydrogen atom or the like. | 05-27-2010 |
20100137372 | ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL - An isoxazoline compound represented by the formula (I): wherein the substituents are as defined in the description, has controlling activity against pests. | 06-03-2010 |
20100144797 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT - Novel pest control agents, particularly insecticides or miticides are provided. Isoxazoline-substituted benzamide compounds of General Formula (1) or a salt thereof: | 06-10-2010 |
20100152246 | 5-Oxoisoxazoles as inhibitors of lipases and phospholipases - The present invention relates to 5-oxoisoxazole derivatives of the formula I, the pharmaceutically usable salts thereof and the use thereof as medicinal substances. | 06-17-2010 |
20100152247 | MEDICAMENT FOR TREATING SCHIZOPHRENIA COMPRISING CILOSTAZOL - The invention relates to a medicament for preventing and/or treating schizophrenia which comprises as an active ingredient cilostazol or a pharmaceutically acceptable salt thereof. | 06-17-2010 |
20100173948 | ANIMAL PEST CONTROL METHOD - Disclosed is a method for protecting an animal from a parasitic invertebrate pest comprising treating an animal orally or by injection with a pesticidally effective amount of a compound of Formula 1, | 07-08-2010 |
20100179194 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES - The present invention relates to novel aryl isoxazoline derivatives having excellent insecticidal activity as insecticides and represented by the formula: | 07-15-2010 |
20100179195 | ISOXAZOLINE INSECTICIDES - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 07-15-2010 |
20100184809 | Heterocyclic FXR Binding Compounds - The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds. | 07-22-2010 |
20100204280 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE - A compound of Formula, (I) or Formula: (II) | 08-12-2010 |
20100216845 | ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER - The present invention is concerned with novel isoxazole-pyridines of formula I | 08-26-2010 |
20100216846 | TRISUBSTITUTED 1,2,4 TRIAZOLES - The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). | 08-26-2010 |
20100222392 | INSECTICIDAL COMPOUNDS - A compound of formula (I) wherein A | 09-02-2010 |
20100240708 | Alpha-(N-Benzenesulfonamido)Cycloalkyl Derivatives - Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one or both of: (i) the functioning of a γ-secretase enzyme; or (ii) the production of β-amyloid. Such compounds may be beneficial in the treatment of Alzheimer's disease and other conditions. Representative compounds have the following formula I: | 09-23-2010 |
20100249191 | N-Methyl benzamide derivatives - Novel isoxazolines of the formula (I) | 09-30-2010 |
20100249192 | NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. | 09-30-2010 |
20100261759 | SUBSTITUTED OXAZOLIDINONES AND THEIR USE - The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders. | 10-14-2010 |
20100261760 | EP2 Receptor Agonists - The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor. | 10-14-2010 |
20100267775 | OXADIAZOLIDINEDIONE COMPOUND - A pharmaceutical agent having GPR40 receptor agonistic action, particularly a compound which is useful as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus. The present inventors have examined a compound having GPR40 receptor agonistic action, confirmed that an oxadiazolidinedione compound which has a substituent such as a benzyl group, etc. linked with a substituent such as a phenyl group, etc. through a linker at the 2-position of an oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity, and thus completed the invention. The oxadiazolidinedione compound has excellent insulin secretagogue action and anti-hyperglycemic action, and therefore can be used as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus. | 10-21-2010 |
20100273832 | INSECTICIDAL COMPOUNDS - A compound of formula (I): wherein A | 10-28-2010 |
20100298384 | NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS - The present invention relates to novel oxazolidinone compounds of formula (I) with antibacterial activity, their pharmaceutically acceptable salts, their stereoisomers, their prodrugs, pharmaceutical compositions comprising the same and to their use as therapeutic agents | 11-25-2010 |
20100331372 | PYRIDIN-2-YL DERIVATIVES AS IMMUNOMODULATING AGENTS - The invention relates to pyridine derivatives of Formula (I) | 12-30-2010 |
20110015236 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES - The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, preparation intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 01-20-2011 |
20110021573 | ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS - Described herein are compounds that are antagonists of PGD | 01-27-2011 |
20110021574 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in a subject, such as using the disclosed heterocyclic anti-cancer agents. | 01-27-2011 |
20110060011 | OXAZOLE COMPOUNDS COMPOSITIONS AND METHODS OF USE - The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer. | 03-10-2011 |
20110060012 | 4-[3-(ARYLOXY)BENZYLIDENE]-3-METHYL PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS - The present invention relates to compounds of Formula (I), wherein Ar is a 5-membered heteroaryl moiety and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity. | 03-10-2011 |
20110092547 | CHEMICAL COMPOUNDS 979 - Compounds of formula (I), or pharmaceutically-acceptable salts and/or pro-drugs thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, | 04-21-2011 |
20110105566 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES - The present invention relates to hydroximoyl-tetrazole derivatives, their process of preparation, preparation intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 05-05-2011 |
20110112149 | EPOTHILONE ANALOGUES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR USE AND THEIR PREPA RATIONS - The present invention relates to novel 15-membered thiazole lactone or lactam polyketide compounds, their pharmaceutical compositions, their use and their preparations. The disclosed compounds relate to those of general formula I, their preparations and their use for preparing therapeutical compositions used as cell inhibitors. | 05-12-2011 |
20110144164 | Pyridone derivatives as NK3 antagonists - The present invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds. | 06-16-2011 |
20110166184 | INSECTICIDAL COMPOUNDS - A compound of formula (I): wherein A | 07-07-2011 |
20110178132 | PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL - Disclosed is a pyridine compound represented by general formula (I). | 07-21-2011 |
20110184026 | C4-SUBSTITUTED ALPHA-KETO OXAZOLES - The invention provides a series of C4-substituted oxazole compounds having an alpha keto side chain at the 2 position, for example, compounds of formula I. The compounds can inhibit fatty acid amide hydrolase and can be useful for treatment of malconditions modulated by fatty acid amide hydrolase. The invention further provides methods of making compounds of formula I, useful intermediates in the preparation of compounds of formula I, and methods of using compounds of formula I and compositions thereof. | 07-28-2011 |
20110190353 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES - The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 08-04-2011 |
20110224261 | CRYSTALLINE FORM OF 4-(5--4-METHYL-4H-1,2,4-TRIAZOL-3-YL)PYRIDINE - The present invention relates to a novel crystalline form of 4-(5-{(IR)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine. Further, the present invention also relates to the use of the novel crystalline form for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it. | 09-15-2011 |
20110237629 | AMINO ACID ESTER PRODRUGS AND THE USE THEREOF - The present application relates to amino acid ester prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitriles, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders. | 09-29-2011 |
20110245296 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS - Heteroaromatic compounds of Formula I: | 10-06-2011 |
20110275678 | New Pyridine Derivatives as Leptin Receptor Modulator Mimetics - The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias. | 11-10-2011 |
20110288131 | INSECTICIDAL COMPOUNDS - A compound of formula (I) wherein A | 11-24-2011 |
20110294855 | Active Compound Combinations - The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) the compound 3-(difluoromethyl)-N-[2-(1,1,2,3,3,3-hexafluoro propoxy)phenyl]-1-methyl-1H-pyrazole-4-carboxamide of formula (I) and/or the compound 3-(di fluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide of formula (II) and (B) at least one azolylmethyloxirane of formula (III). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. | 12-01-2011 |
20110294856 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE - This invention relates to novel oxadiazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. | 12-01-2011 |
20110294857 | INHIBITOR OF CASEIN KINASE 1DELTA AND CASEIN KINASE 1EPSILON - There is provided an inhibitor that inhibits casein kinase 1δ and casein kinase 1ε, and thus, there is also provided a pharmaceutical agent useful for the treatment and/or prevention of a disease, with the pathological condition of which the mechanism of activation of casein kinase 1δ or casein kinase 1ε is associated. Particularly, the above-described inhibitor is used to provide a pharmaceutical agent useful for the treatment of circadian rhythm disorder (including sleep disorder), central neurodegenerative disease, and cancer. | 12-01-2011 |
20110301204 | ADMINISTRATION REGIME FOR NITROCATECHOLS - The present invention relates to novel dosage regimens for compounds of formula I: where the substituents are as defined in the specification. | 12-08-2011 |
20110301205 | ISOXAZOLE DERIVATIVES FOR USE AS FUNGICIDES - The present invention relates to isoxazole compounds of formula (I) having fungicidal activity, to agricultural compositions comprising them, and to the use of said compounds and compositions in agriculture for the control of microbial pests, particularly fungal pests, on plants. | 12-08-2011 |
20120004268 | INSECTICIDAL COMPOSITIONS COMPRISING CYCLIC CARBONYLAMIDINES - Compositions comprising at least one cyclic carbonylamidine of the formula (I) | 01-05-2012 |
20120015981 | Active compound combinations - The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) the compound 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide of formula (I) and/or the compound 3-(difluoromethyl)-1-methyl-N-(2′.4′.5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide of formula (II) and (B) at least one azolylmethyloxirane of formula (III). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. | 01-19-2012 |
20120035218 | PEST CONTROL COMPOSITION | 02-09-2012 |
20120035219 | Compound for the Treatment of Tuberculosis - (5R)-3-[4-[1-[(2S)-2,3-dihydroxypropanoyl]-3,6-dihydro-2H-pyridin-4-yl]-3,5-difluoro-phenyl]-5-(isoxazol-3-yloxymethyl)oxazolidin-2-one, or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, for use in the treatment of | 02-09-2012 |
20120041031 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS - Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist. | 02-16-2012 |
20120071515 | NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF - The present invention discloses a nitropyridinyl ethyleneimine compound as shown in the formula I and a preparation method of the same, as well as use of the compound in manufacture of a prodrug and in manufacture of a drug for treating a tumor. | 03-22-2012 |
20120095056 | 2,5-DISUBSTITUTED TETRAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS - This invention relates to novel tetrazole derivatives of formula (I), which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. | 04-19-2012 |
20120108638 | PYRIDIN-4-YL DERIVATIVES - The invention relates to pyridine derivatives of Formula (I), wherein A, R | 05-03-2012 |
20120129891 | SULFONE DERIVATIVE - Provided are a compound having an excellent hypoglycemic action, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause an increase in the blood sugar level due to abnormal sugar metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed. | 05-24-2012 |
20120136029 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 2-ARYL PYRIDYLAZOLES - A 2-aryl-pyridylazole compound and derivatives useful in slowing the growth of cancer cells are disclosed. Also disclosed are methods of synthesizing the compound, methods of using pharmaceutical compositions containing the compound as an ingredient to slow the growth of cancer cells, and methods of treating cancer patients with pharmaceutical compositions containing the compound as an ingredient. | 05-31-2012 |
20120142739 | NOVEL OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS - The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. | 06-07-2012 |
20120190713 | ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS - The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: | 07-26-2012 |
20120196902 | SULFOXIMINES AS KINASE INHIBITORS - The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. | 08-02-2012 |
20120196903 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS - The invention relates to compounds of formula I | 08-02-2012 |
20120196904 | NITROCATECHOL DERIVATIVES AS COMT INHIBITORS - New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders. | 08-02-2012 |
20120202852 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS - The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved. | 08-09-2012 |
20120208852 | Heterocyclic-substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof - The present application relates to new, heterocyclyl-substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders. | 08-16-2012 |
20120214848 | [1,2,4]OXADIAZOL-3-YL ACID SALTS AND CRYSTALLINE FORMS AND THEIR PREPARATION - The present invention relates to salts and crystalline forms of [1,2,4]oxadiazol-3-yl]-phenoxy}-cycloalkyl carboxylic acids, processes for their preparation, pharmaceutical compositions comprising such compounds, and methods of using them. | 08-23-2012 |
20120232116 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS - The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of the NR1 H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds. | 09-13-2012 |
20120258986 | OLEFIN CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF - The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic). | 10-11-2012 |
20120258987 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS - Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases. | 10-11-2012 |
20120302607 | C4-SUBSTITUTED ALPHA-KETO OXAZOLES - The invention provides a series of C4-substituted oxazole compounds having an alpha keto side chain at the 2 position, for example, compounds of formula I. The compounds can inhibit fatty acid amide hydrolase and can be useful for treatment of malconditions modulated by fatty acid amide hydrolase. The invention further provides methods of making compounds of formula I, useful intermediates in the preparation of compounds of formula I, and methods of using compounds of formula 1 and compositions thereof. | 11-29-2012 |
20130012546 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES - The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 01-10-2013 |
20130012547 | INSECTICIDAL COMPOUNDS - The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests. | 01-10-2013 |
20130131115 | PEST CONTROL COMPOSITION - A pest control composition comprising a hydrazide compound shown by formula (1) below (in the formula, G, M, Q | 05-23-2013 |
20130131116 | PEST CONTROL COMPOSITION - A pest control composition comprising a hydrazide compound shown by formula (1) below (in the formula, G, M, Q | 05-23-2013 |
20130131117 | PEST CONTROL COMPOSITION - A pest control composition comprising a hydrazide compound shown by formula (1) below (in the formula, G, M, Q | 05-23-2013 |
20130131118 | PEST CONTROL COMPOSITION - A pest control composition comprising a hydrazide compound shown by formula (1) below (in the formula, G, M, Q | 05-23-2013 |
20130137729 | USE OF LEVODOPA, CARBIDOPA AND ENTACAPONE FOR TREATING PARKINSON'S DISEASE - The present disclosure provides a method for the treatment of Parkinson's disease comprising simultaneously or sequentially administering to a patient in need of treatment of Parkinson's disease a dosage form comprising
| 05-30-2013 |
20130137730 | INHIBITOR OF CASEIN KINASE 1DELTA AND CASEIN KINASE 1E - There is provided a novel oxazolone derivative having inhibitory activity against casein kinase 1δ and casein kinase 1ε. In addition, the present inhibitor inhibits casein kinase 1δ and casein kinase 1ε, and thus there is also provided a pharmaceutical agent useful for the treatment and/or prevention of diseases, with the pathological conditions of which the activation mechanism of casein kinase 1δ or casein kinase 1ε is associated. There is further provided a pharmaceutical agent useful for the treatment of particularly, circadian rhythm disorder (including sleep disorder), central neurodegenerative disease, and cancer. | 05-30-2013 |
20130158076 | Methylene Urea Derivatives - The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 06-20-2013 |
20130190361 | SUBSTITUTED OXADIAZOLE COMPOUNDS - Disclosed are compounds of Formula (I): | 07-25-2013 |
20130203817 | Novel Inhibitors of LYN Kinase - The invention includes novel compounds that inhibit LYN kinase activity. The invention further includes a method of treating, ameliorating or preventing cancer in a subject in need thereof, wherein the cancer is dependent on LYN kinase activity. | 08-08-2013 |
20130267563 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA or IB: wherein HY, R | 10-10-2013 |
20130281492 | NOVEL OXAZOLIDINONE DERIVATIVES - The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as | 10-24-2013 |
20130289077 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES - The present invention relates to hydroximoyl-heterocycle derivatives of formula (I) | 10-31-2013 |
20130296381 | ISOXAZOLE DERIVATIVES FOR USE AS FUNGICIDES - The present invention relates to isoxazole compounds of formula (I) having fungicidal activity, to agricultural compositions comprising them, and to the use of said compounds and compositions in agriculture for the control of microbial pests, particularly fungal pests, on plants | 11-07-2013 |
20130296382 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS - Heteroaromatic compounds of Formula I: | 11-07-2013 |
20130317068 | SUBSTITUTED 1,2,4-TRIAZOLE COMPOUNDS AS A SEED TREATMENT TO CONTROL PESTS - Methods of using substituted 1,2,4-triazole compounds as a seed treatment to control pests, such as insects and mites. | 11-28-2013 |
20130317069 | 2,4-(SUBSTITUTED AROMATIC)-1,3-OXAZOLINE COMPOUNDS AS A SEED TREATMENT TO CONTROL PESTS - Methods of using 2,4-(substituted aromatic)-1,3-oxazoline compounds as a seed treatment to control pests, such as insects and mites. | 11-28-2013 |
20130324578 | ADMINISTRATION REGIME FOR NITROCATECHOLS - A compound of formula (I) | 12-05-2013 |
20130331416 | DOSAGE REGIMEN FOR COMT INHIBITORS - The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders, wherein said medicament is administered according to a dosing regimen having a dosing periodicity ranging from about twice a day to about once every other day. | 12-12-2013 |
20130338196 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING - Compounds are disclosed that are effective in inhibition of fatty acid amide hydrolase, an enzyme responsible for catabolism of endogenous cannabinoids such as anandamide. The compounds are useful as analgesic compounds and as sleep-inducing compounds, that can be orally administered, and that can have a relatively long duration of effect. Methods of preparation of the compounds are also provided. The compounds are conformationally constrained analogs of heterocyclylketones such as oxazolylketones. | 12-19-2013 |
20140005229 | FUNGICIDAL AQUEOUS SUSPENSION COMPOSITION FOR AGRICULTURE AND HORTICULTURE | 01-02-2014 |
20140005230 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES | 01-02-2014 |
20140024682 | PHARMACEUTICAL COMPOUNDS - This invention relates to novel substituted nitrocatechol derivatives, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them. | 01-23-2014 |
20140039013 | Composition for Inhibition of Insect Host Sensing - The present invention provide chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit host targeting functions in insects such as mosquitoes. Method of employing such agents, and articles incorporating the same, are also provided. | 02-06-2014 |
20140045900 | ADMINISTRATION REGIME FOR NITROCATECHOLS - A compound of formula (I) where R | 02-13-2014 |
20140057951 | SUBSTITUTED OXAZOLIDINONES AND THEIR USE - The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders. | 02-27-2014 |
20140057952 | NOVEL OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS - The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. | 02-27-2014 |
20140066483 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS - Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist. | 03-06-2014 |
20140107161 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES - The present invention provides compounds of formula (I) wherein R | 04-17-2014 |
20140135364 | PESTICIDAL COMPOSITIONS - Pesticidal compositions and their uses are disclosed. | 05-15-2014 |
20140206726 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES - The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 07-24-2014 |
20140213616 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS - The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: | 07-31-2014 |
20140243375 | ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS - The present invention provides compounds of formula I wherein G | 08-28-2014 |
20140296296 | Biaryl-Propionic Acid Derivatives and their Use as Pharmaceuticals - The present invention relates to compounds of the formula I, | 10-02-2014 |
20140323524 | Anti-Proliferative Compounds and Methods for Using the Same - Disclosed herein are anti-proliferative compounds which find use in inhibiting the growth of cancer cells. Also provided herein are methods for using these compounds for inhibiting growth of cancer cells. Also provided herein are methods for using these compounds for treating a subject for hyperproliferative conditions, including without limitation the treatment of hematopoietic cancers. | 10-30-2014 |
20140350057 | CHEMICAL COMPOUND USEFUL AS INTERMEDIATE FOR PREPARING A CATECHOL-O-METHYLTRANSFERASE INHIBITOR - There is disclosed a methylated intermediate which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate. | 11-27-2014 |
20140350058 | FUNGICIDAL 3-[(PYRIDIN-2-YLMETHOXYIMINO)(PHENYL)METHYL]-2-SUBSTITUTED-1,2,- 4-OXADIAZOL-5(2H)-ONE DERIVATIVES - The present invention relates to 3-[(pyridin-2-ylmethoxyimino)(phenyl)methyl]-2-substituted-1,2,4-oxadiazol-5(2H)-one derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 11-27-2014 |
20140350059 | NOVEL OXAZOLIDINONE DERIVATIVES - The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as | 11-27-2014 |
20150299143 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE COMPOUNDS - The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease. | 10-22-2015 |
20150299146 | TETRAZOLINONE COMPOUND AND APPLICATIONS THEREOF - The compound represented by formula (1): | 10-22-2015 |
20150336903 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE - The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications. | 11-26-2015 |
20150359783 | PHARMACEUTICAL FORMULATIONS COMPRISING NITROCATECHOL DERIVATIVES AND METHODS OF MAKING THEREOF - The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined herein and salts, esters, hydrates, solvates and derivatives thereof and methods of making said compositions and pharmaceutical formulations. | 12-17-2015 |
20160000078 | FUNGICIDAL 3--OXADIAZOLONE DERIVATIVES - The present invention provides 4-substituted-3-{phenyl[(heterocyclylmethoxy)imino]methyl}-1,2,4-oxadiazol-5(4H)-one derivatives of formula (I) | 01-07-2016 |
20160000083 | METHOD FOR CONTROLLING PHYTOPATHOGENIC FILAMENTOUS FUNGI OTHER THAN OOMYCETE MICROORGANISMS - Phytopathogenic filamentous fungi other than oomycete microorganisms are controlled using at least one compound selected from among tetrazoyloxime derivatives represented by formula (I) and salts thereof | 01-07-2016 |
20160002215 | PYRIDINE DERIVATIVES AS REARRANGED DURING TRANSFECTION (RET) KINASE INHIBITORS - This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity. | 01-07-2016 |
20160009699 | DOSAGE REGIMEN FOR COMT INHIBITORS | 01-14-2016 |
20160009700 | CHEMICAL COMPOUND USEFUL AS INTERMEDIATE FOR PREPARING A CATECHOL-O-METHYLTRANSFERASE INHIBITOR | 01-14-2016 |
20160031866 | PYRIDIN-4-YL DERIVATIVES - The invention relates to compounds of the Formula (I), Formula (I) wherein R | 02-04-2016 |
20160039773 | FUMARATE ANALOGS AND USES THEREOF - Aspects of the present disclosure include compounds that find use for the treatment of a variety of autoimmune and inflammatory diseases and disorders. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes. | 02-11-2016 |
20160102072 | FUNGICIDAL COMPOSITIONS - The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. | 04-14-2016 |
20160145235 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES - The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulphide and aryl sulphoxide derivatives have the general structure (I) | 05-26-2016 |
20160194292 | TRIAZOLONE COMPOUNDS AND USES THEREOF | 07-07-2016 |
20160249617 | TETRAZOLINONE COMPOUND AND USE THEREOF | 09-01-2016 |
20190142804 | FLUOROALKYL-SUBSTITUTED ARYLTRIAZOLE DERIVATIVES AND USES THEREOF | 05-16-2019 |
20190144423 | AMIDE-SUBSTITUTED PYRIDINYLTRIAZOLE DERIVATIVES AND USES THEREOF | 05-16-2019 |
20190144436 | ADMINISTRATION REGIME FOR NITROCATECHOLS | 05-16-2019 |
20220135550 | SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS - Disclosed are compounds of Formula (I): | 05-05-2022 |