Entries |
Document | Title | Date |
20080200513 | Pyridine N-Oxides As Antiviral Agents - The present invention relates to pyridinone derivatives of formula (I): | 08-21-2008 |
20080214617 | Carbamate compounds - Carbamate compounds having a structure represented by formula I (where R | 09-04-2008 |
20080221166 | AMINOAMIDES AS OREXIN ANTAGONISTS - The present invention relates to compounds of formula I | 09-11-2008 |
20080255198 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR - The present invention relates to compounds of formula (I) | 10-16-2008 |
20080280952 | Pyridine Derivatives as Connabinoid Receptor Modulators - The present invention relates to novel pyridine derivatives such as compounds of the formula (I): | 11-13-2008 |
20080280953 | Agents Used for the Treatment of Seeds - The present invention relates to inter alia the use of known compounds for the treatment of seed. | 11-13-2008 |
20080300281 | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas - This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy. | 12-04-2008 |
20080306117 | EP4 RECEPTOR ANTAGONISTS - A compound of formula (I): | 12-11-2008 |
20090005420 | Inhibitors of Matrix Metallaproteinases - The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith. | 01-01-2009 |
20090012127 | Thiophene-2-Carboxamide Derivatives as Alpha 7 Nicotinic Receptor Modulators - Compounds of Formula (I) wherein E, A and R1 are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same. | 01-08-2009 |
20090018168 | THERAPEUTIC SUBSTITUTED CHLOROCYCLOPENTANOLS - Disclosed herein is a compound having a formula | 01-15-2009 |
20090018169 | Sulfonamide Derivatives for the Treatment of Bacterial Infections - This present invention is related to sulfonamide derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of bacterial infections such as tuberculosis. | 01-15-2009 |
20090023781 | Haloalkyl Containing Compounds as Cysteine Protease Inhibitors - The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them. | 01-22-2009 |
20090023782 | INCREASING PLANT VIGOR - Compositions and processes for improving plant vigor are disclosed. | 01-22-2009 |
20090062346 | DEUTERIUM-ENRICHED TIPRANAVIR - The present application describes deuterium-enriched tipranavir, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 03-05-2009 |
20090069382 | Bicyclic Angiotensin II Agonists - There is provided a compound of formula I, | 03-12-2009 |
20090105306 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS - The present invention relates compounds of formula (I) | 04-23-2009 |
20090143437 | EP4 RECEPTOR ANTAGONISTS - Compounds of formula (X): | 06-04-2009 |
20090163549 | Pharmaceutical Composition Comprising an Amide Derivative - The present invention provides a novel modulator of the TRPV1-receptor function, comprising a compound of the formula; wherein ring A is an optionally substituted carbocycle or heterocycle, ring B is an optionally substituted benzene ring or an optionally substituted 6-membered heteroaromatic ring containing N atom, a dashed line means existence or absence of a bond, n is 1 or 2, R | 06-25-2009 |
20090170902 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE - Compounds of formula (I), salts and solvates thereof are provided: | 07-02-2009 |
20090176836 | Cyclic Ketal Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease - The present invention is directed to cyclic ketal compounds of formula (I) | 07-09-2009 |
20090176837 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS - Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders such as memory deficits and schizophrenia, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, inflammatory disorders such as psoriasis and rheumatoid arthritis, eye disorders and depression. | 07-09-2009 |
20090209590 | Histone Deacetylase and Tubulin Deacetylase Inhibitors - In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes—“isotubacin” class and “isoisotubacin” class—all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention. | 08-20-2009 |
20090215827 | INHIBITORS OF CXCR2 - The invention relates to compounds of the formula I | 08-27-2009 |
20090215828 | Substituted indole derivatives - Substituted indole derivatives, processes for the preparation thereof, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted indole derivatives to treat pain and other conditions and for other medical purposes. | 08-27-2009 |
20090215829 | THIOPHENE CARBOXAMIDES AS INHIBITORS OF THE ENZYME IKK-2 - The invention relates to thiophene carboxamides of formula (I), | 08-27-2009 |
20090221643 | 4-PHENYL-3-(2-PROPYLSULFONYLAMINO) TETRAHYDROFURAN DERIVATIVES WHICH POTENTIATE GLUTAMATE RECEPTORS AND ARE USEFUL IN THE TREATMENT OF SCHIZOPHRENIA - Compounds of formula (I), salts and solvates thereof are provided: | 09-03-2009 |
20090253749 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS - The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. | 10-08-2009 |
20090258904 | Epithiolone Analogues - Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain. | 10-15-2009 |
20090258905 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS - Compounds of formula (I): | 10-15-2009 |
20090281145 | ALLOSTERIC ENHANCERS OF THE A1 ADENOSINE RECEPTOR - The present invention provides compounds of formula (I) | 11-12-2009 |
20090306142 | METHODS TO CONTROL QoI-RESISTANT FUNGAL PATHOGENS - Processes and compositions have been discovered that are suitable for controlling a pathogen induced disease in a plant that is at risk of being diseased from a pathogen resistant to a Qo inhibitor. Such processes and compositions comprise contacting said plant(s) with a composition comprising an effective amount of a Qi inhibitor. | 12-10-2009 |
20100004290 | INSECTICIDAL N-SUBSTITUTED (HETEROARYL)CYCLOALKYL SULFOXIMINES - N-Substituted (heteroaryl)cycloalkyl sulfoximines are effective at controlling insects. | 01-07-2010 |
20100035932 | NOVEL FORMYL PEPTIDE RECEPTOR LIKE 1 AGONISTS THAT INDUCE MACROPHAGE TUMOR NECROSIS FACTOR ALPHA AND COMPUTATIONAL STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF THEREOF - The present invention provides compounds of structural formula (I), which are agonists of formyl peptide receptor (FPR), particularly formyl peptide receptor like 1 (FPRL1). The present invention also provides the therapeutic use of the compounds of formula (I). | 02-11-2010 |
20100048636 | Aspartic Protease Inhibitors - The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors. | 02-25-2010 |
20100056578 | INSECTICIDAL N-SUBSTITUTED SULFOXIMINES - N-Substituted sulfoximines are effective at controlling insects. | 03-04-2010 |
20100056579 | INSECTICIDAL N-SUBSTITUTED SULFOXIMINES - N-Substituted sulfoximines are effective at controlling insects. | 03-04-2010 |
20100069440 | PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE - Disclosed are compounds of the formula I: | 03-18-2010 |
20100087487 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES - The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved. | 04-08-2010 |
20100130556 | EP2 RECEPTOR AGONISTS - A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R | 05-27-2010 |
20100144794 | INSECTICIDAL N-SUBSTITUTED (6-HALOOALKYLPYRIDIN-3-YL)-ALKYL SULFOXIMINES - N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects. | 06-10-2010 |
20100152244 | SELF-EMULSIFYING FORMULATION OF TIPRANAVIR FOR ORAL ADMINISTRATION - A self-emulsifying formulation of tipranavir for oral administration. | 06-17-2010 |
20100152245 | INSECTICIDAL N-SUBSTITUTED (6-HALOOALKYLPYRIDIN-3-YL)-ALKYL SULFOXIMINES - N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects. | 06-17-2010 |
20100168176 | NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME - Compounds having the following general formula, pharmaceutical compositions comprising the compounds, and methods of treating cancer, obesity, and microbial infections using such compositions: wherein: R1=H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, cyanomethyl, —OCH3, OC(O)CH3 or OC(O)CF3 R2=-OCH2C(O)NHNH—R5, where R5 is (a) phenyl, optionally substituted with one or more of halogen, C1-C8 alkyl, optionally substituted with halogen, —OH, —OR6, where R6 is C1-C8 alkyl, optionally substituted with halogen, or (b) 2-, 3-, or 4-pyridyl, optionally substituted with halogen, —OH, —OR6, where R6 is C1-C8 alkyl, optionally substituted with halogen, or (c) a heterocycle selected from the group consisting of imidazole, thiazole, benzimidazole, benzoxazole, benzthiazole, tetrazole, triazole, and aminothiazole; or (d) —C(O)R7, where R7 is a C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, or a heterocycle selected from the group consisting of pyridyl, imidazole, thiazole, benzimidizole, benzoxazole, benzthiazole, tetrazole, triazole, and aminothiazole; and R3 and R4, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. | 07-01-2010 |
20100168177 | Stable insecticide compositions - Insect controlling compositions including an N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compound and an organic acid or a salt thereof exhibit increased stability. | 07-01-2010 |
20100168178 | Stable insecticide compositions and methods for producing same - Insect controlling compositions including an N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compound exhibiting increased stability, along with methods for preparing same, are disclosed. | 07-01-2010 |
20100168179 | 6-ALKENYL-, 6-ALKINYL- AND 6-EPOXY-EPOTHILONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE IN PHARMACEUTICAL PREPARATIONS - This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R | 07-01-2010 |
20100173943 | INSECTICIDAL COMPOSITIONS WITH IMPROVED ACTION - The present invention relates to enhancement of the action of crop protection compositions comprising enaminocarbonyl compounds by the addition of ammonium salts and/or phosphonium salts or by the addition of ammonium or phosphonium salts and penetrants, to the corresponding compositions, to processes for their production and to their use in crop protection. | 07-08-2010 |
20100197737 | ACTIVE AGENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES - The present invention relates to novel active substance combinations which contain firstly at least one known compound of the formula (I) | 08-05-2010 |
20100210689 | THERAPEUTIC SUBSTITUTED CHLOROCYCLOPENTANOLS - Disclosed herein is a compound having a formula | 08-19-2010 |
20100222389 | NOVEL MICROBIOCIDES - Compounds of the formula (I), in which the substituents are as defined in claim | 09-02-2010 |
20100240705 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS USED AS INSECTICIDES - The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. | 09-23-2010 |
20100240706 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES - The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) | 09-23-2010 |
20100267774 | P38 MAP KINASE INHIBITORS - Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: formula (I) wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R | 10-21-2010 |
20100280076 | DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS - A compound corresponding to general formula (I): | 11-04-2010 |
20100286207 | Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same - The present invention is related to new 2-oxo-cyclic compound, the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases. | 11-11-2010 |
20100311795 | 1,3-DIOXANE CARBOXYLIC ACIDS - The present invention relates to novel 1,3-dioxane carboxylic acids of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. | 12-09-2010 |
20110003860 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES - The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents. | 01-06-2011 |
20110039894 | SUBSTITUTED ENAMINOTHIOCARBONYL COMPOUNDS - The present application relates to novel substituted enaminothiocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. | 02-17-2011 |
20110105565 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - Provided herein are highly water soluble, thiazolidinone derivative compounds and glycine hydrazide derivative compounds that inhibit the ion transport activity of the cystic fibrosis transmembrane conductance regulator (CFTR). The compounds, and compositions comprising the compounds, described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea. The compounds may also be used for inhibiting expansion or preventing formation of cysts in persons who have polycystic kidney disease. | 05-05-2011 |
20110136872 | STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF - The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders. | 06-09-2011 |
20110178129 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 07-21-2011 |
20110207778 | Active compound combination comprising azadirachtin and a substituted enaminocarbonyl compound - Disclosed are novel active compound combinations comprising at least one substituted enaminocarbonyl compound and azadirachtin, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids. Methods of controlling insects and acarids are also disclosed. | 08-25-2011 |
20110281915 | Thienodithiine Derivatives - The present invention relates to new thienodithiine derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these thienodithiine derivatives. | 11-17-2011 |
20110306639 | HYDROCARBYLIDENE NITROHYDROZINECARBOXIMIDAMIDES AND A METHOD FOR MAKING THE SAME, AS WELL AS THEIR USES AS AN INSECTICIDE - The present invention discloses hydrocarbylidene nitrohydrozinecarboximidamides and the use thereof as well as a method for making the same. The structural general formula of the compounds are shown in formula I, wherein, R1 is C1-C10 saturated and/or unsaturated aliphatic hydrocarbonyl, benzyl, substituted benzyl, halogenated picolyl, halogenated thiazolyl methyl, tetrahydrofuryl methyl or oxazolyl methyl; R2 is hydrogen, C1-C5 saturated and/or unsaturated aliphatic hydrocarbonyl, phenyl, substituted phenyl, pyridyl or substituted pyridyl; R3 is hydrogen, C1-C10 saturated and/or unsaturated aliphatic hydrocarbonyl, furyl, phenyl, substituted phenyl, benzyl or substituted benzyl. The tests of insecticidal activity show that the hydrocarbylidene nitrohydrozinecarboximidamides shown by formula (I) have high preventive efficiency against insect pests of plants, such as aphid, plant hopper, cotton bollworm, asparagus caterpillar, and the like, and can be used as plant insecticides. | 12-15-2011 |
20120059038 | POLYKETIDE COMPOUND | 03-08-2012 |
20120059039 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE - Septic shock is known to lead to, at the end stage, systematic inflammatory reaction syndrome and multiple organ failure (MOF) and cause the patients' death. In both diseases, the patient dies finally of MOF, and the infiltration by inflammatory cells plays a key role for MOF. Thus, development of therapeutic agents for septic shock by suppressing the infiltration by inflammatory cells has been desired. | 03-08-2012 |
20120108636 | Allosteric Enhancers of th A1 Adenosine Receptor - The present invention provides compounds of formula (I) | 05-03-2012 |
20120157498 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS - The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. | 06-21-2012 |
20120208851 | FORMULATIONS - Colloidal suspensions comprising a therapeutic agent and squalene. Squalene binds to certain compounds, such as gacyclidine, much more tightly than other drug carriers, such as polylactic glycolic acid. Including squalene in the particulate phase sequesters the therapeutic agent and provides superior stability at room or body temperature. | 08-16-2012 |
20120225908 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES - The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents. | 09-06-2012 |
20120270904 | CO-CRYSTAL OF 4-FURAN-2(5H)-ONE WITH OXALIC ACID AND USE THEREOF AS PESTICIDE - The invention relates to a new co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one with oxalic acid, and also to processes for preparation thereof and use. | 10-25-2012 |
20120283294 | CO-CRYSTAL OF 4-FURAN-2(5H)-ONE WITH BENZOIC ACID AND USE THEREOF AS PESTICIDE - The invention relates to a new co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino} furan-2(5H)-one with benzoic acid, to processes for the preparation thereof and use thereof. | 11-08-2012 |
20130005774 | TOPICAL FOAM COMPOSITION - The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase. | 01-03-2013 |
20130079373 | Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands - The invention relates to substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders. | 03-28-2013 |
20130123304 | PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE - Disclosed are compounds of the formula I: | 05-16-2013 |
20130190356 | BENZYL SULFONAMIDE DERIVATIVES AS RORC MODULATORS - Compounds of the formula I: | 07-25-2013 |
20130289073 | CHEMICAL INHIBITORS OF CHOLESTEROL BIOSYNTHESIS AND VENOUS ANGIOGENESIS - This invention relates, e.g., to a compound, aplexone, and pharmaceutically acceptable salts and solvates, and functional variants, thereof. Methods of using the compounds and pharmaceutical compositions comprising them, e.g. to inhibit angiogenesis and to reduce cellular cholesterol levels, are also included. | 10-31-2013 |
20130296372 | USE OF PRO-FUNGICIDES OF UK-2A FOR CONTROL OF SOYBEAN RUST - The present disclosure is related to the field of agrochemicals, including profungicides of UK-2A and their use to control soybean rust. | 11-07-2013 |
20130296373 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-07-2013 |
20130296374 | USE OF PRO-FUNGICIDES OF UK-2A FOR CONTROL OF BLACK SIGATOKA - The present disclosure is related to the field of agrochemicals, including profungicides of UK-2A and their use to control Black Sigatoka. | 11-07-2013 |
20130296375 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-07-2013 |
20130317067 | PESTICIDAL MIXTURES WITH IMPROVED PROPERTIES - The present invention relates to novel pesticidal compositions comprising the crystalline modification I of 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one and a fungicidally active compound that show surprisingly good insecticidal, acaricidal, nematicidal and fungicidal activities. In particular, these compositions are suited for the treatment of seed. | 11-28-2013 |
20140018395 | Controlled Release Auris Sensory Cell Modulator Compositions and Methods for the Treatment of Otic Disorders - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 01-16-2014 |
20140031394 | CYCLIC SULFONIUM SALT, PROCESS FOR PRODUCTION OF SAME, AND alpha-GLUCOSIDASE INHIBITOR COMPRISING SAME - Provided is a novel cyclic sulfonium salt compound which is useful for the prevention or treatment of diabetes and the like. The present invention relates to a novel cyclic sulfonium salt compound represented by general formula (I) or (II), an isomer or solvate of the compound, or a pharmaceutically acceptable salt of the compound or the isomer or solvate. The present invention also relates to an α-glucosidase inhibitor, a pharmaceutical composition for preventing or treating diabetes, and an anti-diabetes food, each of which comprises the compound represented by general formula (I) or (II) and the like. | 01-30-2014 |
20140135362 | INSECTICIDAL N-SUBSTITUTED (6-HALOALKYLPYRIDIN-3-YL)-ALKYL SULFOXIMINES - N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects. | 05-15-2014 |
20140187587 | SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS - A fungicidal composition containing a fungicidally effective amount of (a) the compound of Formula I, (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate, and (b) fluxapyroxad, provides synergistic control of selected fungi. | 07-03-2014 |
20140187588 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The disclosure relates to macrocyclic picolinamides of Formula (I) and to the use of these compounds as fungicides. | 07-03-2014 |
20140187589 | FUNGICIDAL COMPOSITIONS FOR CONTROLLING LEAF SPOTS IN SUGAR BEETS - A new method for the control and prevention of sugar beet leaf spot caused by | 07-03-2014 |
20140187590 | SYNERGISTIC FUNGICIDAL COMPOSITIONS - A synergistic fungicidal mixture contains a fungicidally effective amount of a compound of Formula I, (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate, and at least one triazole fungicide wherein Formula I is | 07-03-2014 |
20140200245 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 07-17-2014 |
20140243374 | Novel Sulfonamides - This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase. | 08-28-2014 |
20140275171 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 09-18-2014 |
20140323523 | Positive allosteric modulators of nicotinic acetylcholine receptor - The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor. | 10-30-2014 |
20140371274 | BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention relates to novel compounds, their use in the prevention or treatment of symptoms and disorders associated with the bradykinin B | 12-18-2014 |
20150038535 | Thiophene-carboxamides useful as inhibitors of protein kinases - The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. | 02-05-2015 |
20150080432 | INSECTICIDAL N-SUBSTITUTED (6-HALOALKYLPYRIDIN-3-YL)-ALKYL SULFOXIMINES - N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects. | 03-19-2015 |
20150094339 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY - The invention relates to compounds of macrocyclic picolinamides of Formula I suitable to control or prevent growth of fungi. | 04-02-2015 |
20150094340 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 04-02-2015 |
20150105429 | BENZYL SULFONAMIDE DERIVATIVES AS RORC MODULATORS - Compounds of the formula I: | 04-16-2015 |
20150126559 | NOVEL ANTI-CANCER COMPOUNDS - The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R | 05-07-2015 |
20150133503 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING TUBERCULOSIS - The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1; and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle | 05-14-2015 |
20150291573 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES - The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders. | 10-15-2015 |
20150322051 | Macrocyclic picolinamides as fungicides - This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-12-2015 |
20150361072 | PYRIDINE DERIVATIVES AS SOFT ROCK INHIBITORS - The present invention relates to new kinase inhibitors of Formula (I) or a stereoisomer, tautomer, racemic, salt, hydrate, or solvate thereof, and more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including Respiratory and Gastro-Intestinal diseases. | 12-17-2015 |
20160007601 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | 01-14-2016 |
20160007602 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | 01-14-2016 |
20160037774 | SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS - A fungicidal composition containing a fungicidally effective amount of a compound of Formula I, (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate, and at least one fungicide selected from the group consisting of prothioconazole, epoxiconazole, cyproconazole, myclobutanil, prochloraz, metconazole, difenconazole, tebuconazole, tetraconazole, fenbuconazole, propiconazole, fluquinconazole, flusilazole, flutriafol, and fenpropimorph. | 02-11-2016 |
20160130261 | ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS - This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers. | 05-12-2016 |
20160176806 | NOVEL COMPOUNDS | 06-23-2016 |
20160183526 | FUNGICIDAL COMPOSITIONS - Described herein are fungicidal compositions in the form of emulsifiable concentrates that comprise a first fungicidal compound, optionally, at least one additional fungicidal compound, two or more surfactants and a water immiscible organic solvent comprised of a mixture of organic compounds including an acetate ester, an N,N-dialkylcarboxamide and at least one of a ketone and an alcohol. The compositions are homogeneous, stable upon storage, and upon dilution in water form stable emulsions that can be sprayed onto plants to control important fungal diseases. | 06-30-2016 |
20160183527 | FUNGICIDAL COMPOSITIONS - Described herein are fungicidal compositions in the form of an emulsifiable concentrates that include a first fungicidal compound, optionally, at least one additional fungicidal compound, two or more surfactants and a water immiscible organic solvent comprised of a mixture of organic compounds including at least one acetate ester, at least one N,N-dialkylcarboxamide and at least one of a ketone and an alcohol, and methods of use of such compositions to control important fungal diseases of plants. | 06-30-2016 |
20160183528 | FUNGICIDAL COMPOSITIONS - Described herein are fungicidal compositions in the form of an emulsifiable concentrates that include a first fungicidal compound, optionally, at least one additional fungicidal compound, two or more surfactants and a water immiscible organic solvent comprised of a mixture of organic compounds including at least one acetate ester and at least one N,N-dialkylcarboxamide. The compositions are homogeneous, stable upon storage, and upon dilution in water form stable emulsions that can be sprayed onto plants to control important fungal diseases. | 06-30-2016 |
20220133698 | a-SYNUCLEIN AGGREGATE BINDING AGENT AND IMAGING METHOD - The present invention provides an α-synuclein aggregate binding agent that has high binding selectivity for an α-synuclein aggregate. | 05-05-2022 |