Entries |
Document | Title | Date |
20080213344 | Wound dressing and method for controlling severe, life-threatening bleeding - This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site. | 09-04-2008 |
20080241229 | Preparation Method of an Anti-Microbial Wound Dressing and the Use Thereof - The present invention discloses a method for the preparation of an anti-microbial wound dressing comprises alkalizing chitosan fiber to obtain alkalized chitosan fiber which is then etherified with chloroacetic acid to produce carboxymethyl chitosan fiber. Said fiber is made into dressing by fiber opening, web formation and needling. Alternatively chitosan fiber can be made into chitosan non-woven fabric by non-woven technique first which is then carboxylmethylated. The fabric is then made into wound dressing by cutting, packaging and sterilizing. The present invention also discloses the uses of the anti-microbial wound dressing made according to said method. The dressing according to the present invention can be applied in surgical wound, burn, and other chronic wound. Said dressing, when covering wound, is able to prevent moisture losses in body fluid, provide a favorable moist environment necessary for wound healing and maintain a fluid-free, maceration-free, germ-free wound surface. Said dressing is antiphlogistic, hemostatic and antalgic and promotes wound healing. | 10-02-2008 |
20080254103 | Wound Dressings Comprising a Protein Polymer and a Polyfunctional Spacer - There is described a method of forming a wound dressing. The method comprises forming a protein polymer by reacting a protein with a polyfunctional spacer, or an activated derivative thereof. The polyfunctional spacer is preferably a polycarboxylic acid, especially a dicarboxylic acid, and protein polymers prepared using such spacers are suitable for a wide range of therapeutic applications, including use as wound dressings, for the delivery of therapeutically active agents to the body and as bioadhesives and sealants. | 10-16-2008 |
20080254104 | Advanced functional biocompatible polymeric matrix containing nano-compartments - The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein. | 10-16-2008 |
20080286346 | Wound Dressing - A wound dressing comprises a support provided with a first side which is oriented towards the surface which is to be treated and a second opposite side, the support comprising a metal having an antimicrobial effect. A least the first side of the support has a preparation for localized therapy. | 11-20-2008 |
20080286347 | BIOABSORBABLE SYNTHETIC NONWOVEN FABRIC HOLDING THROMBIN - A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis. | 11-20-2008 |
20080317829 | Method for the Production of a Wound Pad - The invention relates to a method for producing a wound pad, by means of which the permeability of the wound pad can be adjusted. The inventive method makes it possible to produce wound pads for a wide range of therapeutic applications. | 12-25-2008 |
20090010994 | Wound Dressing Comprising an Anti-Inflammatory Pain-Killing Agent and a Complex of Silver Ion and a Transitional Element of Group IV of the Periodic System of Elements - A wound dressing comprising one or more absorbent elements capable of absorbing wound exudates, a non-steroid anti-inflammatory pain-killing agent and a complex of silver ion and a transitional element of group IV of the periodic system of elements. | 01-08-2009 |
20090022779 | Phenytoin Formulations, and Uses Thereof in Wound Healing - A formulation of phenyloin suitable for topical application to a wound comprises a reservoir of phenyloin entrapped within a stabilising matrix, and an amount of dissolved phenyloin, wherein the dissolved phenyloin is in chemical equilibrium with the phenyloin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenyloin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention. | 01-22-2009 |
20090022780 | HYDROGEL - The invention is related to gel preparations capable of absorbing as well as releasing liquid, and the use of such gel preparations in the treatment of wounds. | 01-22-2009 |
20090028926 | Method and mixture for in vivo photochemical cross-linking of collagen - A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth. | 01-29-2009 |
20090028927 | POLY(VINYL ALCOHOL) - BACTERIAL CELLULOSE NANOCOMPOSITE - Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such composite materials. | 01-29-2009 |
20090035356 | MODIFIED BIODEGRADABLE POLYMERS, PREPARATION AND USE THEREOF FOR MAKING BIOMATERIALS AND DRESSINGS - The invention concerns a method for preparing a modified biodegradable polymer in aqueous medium comprising at least two steps. The first step is a reaction between an amino acid, a peptide or a polypeptide and maleic anhydride to form a compound having an unsaturated vinyl-carboxylic acid function. In the second reaction step, the unsaturated diacid obtained in the first step is reacted with a biodegradable polymer having at least one primary amine function, such as a fibrous protein or a glycosaminoglycan. The preferred polymer used is collagen or chitosan. The invention also concerns the modified biodegradable polymer obtained by the method. The invention further concerns a biomaterial or a dressing containing the modified biodegradable polymer having biocompatible, cytocompatible, hemostatic, bactericidal and wound healing properties, and its medical, biomedical, pharmaceutical or cosmetic use. | 02-05-2009 |
20090047331 | SUSTAINED RELEASE FILM FORMULATION FOR HEALING WOUND COMPRISING EPIDERMAL GROWTH FACTOR - The present invention relates to a sustained release film formulation for healing wound comprising epidermal growth factor, chitosan, viscosity modifiers, plasticizers, and stabilizers. Specifically, the present invention relates to a sustained release film formulation for healing wound comprising epidermal growth factor as an effective ingredient and chitosan as a main base, and additionally comprising one or more antioxidants selected from the group consisting of EDTA and vitamin C; one or more viscosity modifiers selected from the group consisting of hydroxypropylmethylcellulose, gellan gum and pullulan; and one or more plasticizers selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone thereto. When the present film is attached to wound site, it absorbs exudation from wound site, and so is changed to hydrogel to keep wound site humid, which is good for wound-healing. And, the present film has superior attachment property to human body, and antifungal activity. Thus, the present film has more merits than simple ointment/cream formulation. | 02-19-2009 |
20090047332 | METHODS FOR PRODUCING SILVER-BONDED ANTIMICROBIAL MOIST WOUND DRESSINGS AND MOIST WOUND DRESSINGS PRODUCED BY THE METHODS - A method for producing a silver-bonded antimicrobial moist wound dressing. A silver-containing compound is added to a 0.1-30% aqueous solution of an alkaline solvent to dissociate silver ions from the silver-containing compound, dissolving CMC in water or an organic solvent to obtain a CMC solution, the silver ion-containing solution is mixed with the CMC solution so that the hydrogen ions (H | 02-19-2009 |
20090053287 | POROUS DRESSING - A porous dressing is provided. The porous dressing includes a polymeric layer, a pharmaceutically active ingredient and a metal oxide. The polymeric layer has a porosity and a bio-compatibility, and the pharmaceutically active ingredient and the metal oxide distribute in one selected from a group consisting of in the polymeric layer, on a surface of the polymeric layer and a combination thereof. | 02-26-2009 |
20090060985 | PROCESS FOR THE PREPARATION OF PLANT EXTRACTS FOR TREATING SKIN DISORDERS AND ENHANCING HEALING OF WOUNDS - The present invention provides a process for the preparation of | 03-05-2009 |
20090068251 | METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING - Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds. | 03-12-2009 |
20090074843 | Use of epi-hne 1-4 - The invention relates to use of at least one of the compounds EPI-HNE 1, EPI-HNE 2, EPI-HNE 3 or EPI-HNE 4 for the manufacture of a medicament for treatment of chronic wounds or burns. The EPI-HNE 1-4 compounds are e.g. suitable for incorporation into a wound care device, such as a dressing. | 03-19-2009 |
20090081279 | Skin Dressings - A skin dressing is adapted, on activation, to release one or more S-nitrosothiols, preferably S-nitroso-L-glutathione. S-nitrosothiols decompose spontaneously to produce nitric oxide, which has beneficial effects on tissues, particularly in wound healing. | 03-26-2009 |
20090098193 | HEMOSTATIC COMPOSITIONS AND METHODS FOR CONTROLLING BLEEDING - The disclosure provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions include an article containing cellulose, e.g., cotton gauze, and a cross-linked polysaccharide ionically linked to the cellulose. Methods of making and using the hemostatic compositions are also provided. | 04-16-2009 |
20090117175 | HEMOSTATIC COMPOSITIONS AND THERAPEUTIC REGIMENS - The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to treat wounds. More specifically the present invention relates to hemostatic compositions that reduce the need for, and cost of, nursing care of patients with chronic wounds by reducing the frequency of wound dressing changes. | 05-07-2009 |
20090130185 | Anti-Microbial Compositions Comprising a Cationic Peptide and a Glycylglycine Endopeptidase - There is provided an anti-microbial composition comprising a cationic peptide and a glycineglycine endopeptidase. The composition has been found to be synergistic against bacteria, especially Gram positive bacteria such as | 05-21-2009 |
20090130186 | Wound dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan and incorporating silver nanoparticles - Silver nanoparticles are mixed with a chitosan solution, to form a chitosan/silver nanoparticle dispersion, which is then subjected to a freeze-drying process, to form a chitosan/silver nanoparticle matrix suitable for use as a wound dressing. | 05-21-2009 |
20090155341 | Medical device and a method for applying a biochemically active material on one or more body parts - A medical device having a sleeve-shaped elastic body which is rolled up to form an annular structure and may be rolled down to annularly contacting one or more body parts, such as limbs, a biochemically active material, such as a disinfecting material, added substantially to a portion of the sleeve-shaped elastic body, and a pressure-exerting element for rolling down the sleeve-shaped elastic body while applying an external pressure on a contact point between the portion and the one or more body parts. | 06-18-2009 |
20090162421 | DRUGS AS WELL AS THEIR PRODUCTION AND USE IN THE TREATMENT OF PAIN-ASSOCIATED NEUROPATHIES - The present invention relates to the use of tarenflurbil and/or a pharmaceutically tolerable salt or derivative thereof in enantiomerically-pure and/or essentially enantiomerically-pure form or a form that is enriched with respect to flurbiprofen racemate and/or a racemate of said salt or derivative, for the production of a drug for the treatment of pain-associated neuropathy, pain-associated neuropathy that is simultaneously accompanied by states of nociceptive pain, peripheral and/or predominantly peripheral neuropathic pain or central and/or predominantly central neuropathic pain. | 06-25-2009 |
20090169600 | Hydrogen Peroxide Delivery System - A delivery system, e.g. a skin dressing, comprising an upper component, comprising hydrogen peroxide, and a lower component in hydrated condition, such that when the upper and lower components are placed in contact with each other, hydrogen peroxide migrates towards the lower component is provided. | 07-02-2009 |
20090196909 | CARBON NANOTUBE CONTAINING MATERIAL FOR THE CAPTURE AND REMOVAL OF CONTAMINANTS FROM A SURFACE - There is disclosed an article and method of making an article for removing at least one contaminant from a solid surface. In one embodiment, the article comprises carbon nanotubes attached to a support media, such as a nonwoven mixture of PET and cotton. There is also disclosed a method of removing at least one contaminant from a solid surface, such as areas where microbial, particle, or static contamination is undesirable, including hospitals, clean rooms, kitchens, baths, or human hands. | 08-06-2009 |
20090202615 | Compositions for Treating Biofilms and Methods for Using Same - Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein. | 08-13-2009 |
20090220578 | Hydrogel composition and method for making the same - Disclosed is a hydrogel composition comprising water, a first crosslinked polymer, and a second crosslinked polymer, wherein the first crosslinked polymer comprises poly(ethylene oxide) and the second crosslinked polymer comprises a hydrophilic polymer other than poly(ethylene oxide), wherein the first crosslinked polymer and the second crosslinked polymer form an interpenetrating network (IPN). The hydrogel of the present invention has an attractive combination of water absorption and compressive strength. The hydrogel composition finds use as a drug delivery device. The invention also provides a method of preparing such hydrogel composition. | 09-03-2009 |
20090220579 | Gelatin Non-Woven Structures Produced by a Non-Toxic Dry Solvent Spinning Process - The present application discloses an alternative method for the formation of non-woven with fibers in the 1 to 200 μm range. Using an aqueous solution of gelatin (optionally with <30% of low molecular weight alcohol) the fibers are ejected utilizing pressurized air emitted from nozzle and the non-woven formed directly from the emitted thin fibers. | 09-03-2009 |
20090246260 | FIBRIN FOAM AND PROCESS - A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, is also sufficiently viscous to rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing. | 10-01-2009 |
20090246261 | FIBRIN FOAM AND PROCESS FOR MAKING - A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, will rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing. A fibrin foam may be made by injecting fibrinogen foam into a clotting protein, such as thrombin. | 10-01-2009 |
20090246262 | EASILY APPLIED FIELD DRESSING FOR WOUNDS - A method for treating wounds by adhering a wound dressing to a wound with a polymerizable alkyl cyanoacrylate composition, such that the wound dressing and cyanoacrylate composition seal the wound to inhibit bleeding and infection. The dressing may be in the form of a mitten. Also disclosed is injection of polymerizable cyanoacrylate into puncture wounds to seal the wounds and inhibit bleeding. | 10-01-2009 |
20090258058 | NOVEL SILICONE FILM FORMER FOR DELIVERY OF ACTIVES - The invention provides: a film-forming composition comprising a) a saccharide-siloxane copolymer; b) a crosslinking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent, or solvent mixture, wherein the saccharide-siloxane copolymer has the following formula: R | 10-15-2009 |
20090258059 | Stabilized foam for medical PSA substrate - The present invention provides a method for using a stabilized foam that is a crosslinked, closed cell polyolefin having a stabilizing layer and an adhesive layer. The method can be used for treating a wound, scrape, abrasion or skin puncture, for maintaining cleanliness of an operation incision site, suture site, catheter insertion site, or an intentional skin breach site, for monitoring electrical impulses during an EKG or for delivering electrical impulses in TENS or biofeedback therapy, and for reducing scar formation by softening collagen deposits. | 10-15-2009 |
20090263469 | BIGUANIDE-CONTAINING LIPOSOMES - The present invention relates to biguanide-containing liposomes and antiseptic preparations based on biguanide-containing liposomes, where the liposomes are characterised in that they are essentially free of lipids with anionic head groups, to the preparation of biguanide-containing liposomes and of the antiseptic preparations, and to their possible uses and to the products arising from their use, in particular wound dressings. | 10-22-2009 |
20090297587 | HYDROGEL WOUND DRESSING AND ITS METHOD OF PREPARATION - An improved hydrogel wound dressing and its preparation is disclosed. The ingredients used in the dressing are PAAS of 20˜30 wt %, PVA of 2˜6 wt % and water of 64˜78 wt %. The hydrogel wound dressings were formed by dissolution, casting films, radiation synthesis and sterilization. Compared with conventional hydrogel dressings the improved dressings displayed an enhanced degree of swelling. Cell growth factors may be incorporated into the dressings to be released slowly in the wound. | 12-03-2009 |
20090324695 | BIOCOMPATIBLE POLYMER CERAMIC COMPOSITE MATRICES - Biocompatible composites of flexible polymers/copolymers films and dispersed solid silica-based ceramic microparticles are provided. The composites uniquely combine material and drug delivery properties that are essential for wound dressings and drug delivery applications. The flexible copolymer films are preferably tyrosine-based polycarbonates, and the ceramic microparticles are biodegradable silica-based glass particles that are preferably processed by a sol-gel methodology. The copolymers and the ceramic microparticles independently can contain therapeutic agents, are independently capable of binding these agents, and can independently release such agents. It is sufficient that either the polymer or the ceramic contains therapeutic agents, although both may contain them. | 12-31-2009 |
20100015208 | ANTIBACTERIAL WOUND DRESSING - The present invention relates to wound dressings, in particular to an antibacterial wound dressing based on silvered gel-forming fabric and to a process for the manufacture of such a wound dressing. | 01-21-2010 |
20100021527 | COLLAGEN-RELATED PEPTIDES AND USES THEREOF AND HEMOSTATIC FOAM SUBSTRATES - The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof. The present invention also relates to novel hemostatic foam substrates, a method of manufacturing the foam substrates, and a method of stimulating hemostasis in a mammal using such foam substrates. | 01-28-2010 |
20100080841 | FIBROUS ARTICLES WITH ONE OR MORE POLYELECTROLYTE LAYERS THEREON AND METHODS FOR MAKING THE SAME - Fibrous articles having fibers coated with one or more polyelectrolyte layers are disclosed. Methods of making and using the fibrous articles are also disclosed. | 04-01-2010 |
20100129427 | Hemostatic Wound Dressings - Hemostatic wound dressings for substantially arresting the flow of severe, life threatening bleeding from a wound by rapidly adhering to the wound site, absorbing and concentrating and thickening the blood at the dressing blood interface and accelerating the natural clot formation beneath the dressing and finally, forming a strong seal that will substantially prohibits further flow of blood out of the wound site. These hemostatic wound dressings are formed of unique combinations of hemostatic dressing aspects which achieve wound seal strengths that are significantly higher than the sum of seal strengths expected from the individual aspects alone. Some embodiments also achieve these synergistic seal strengths by combining one hemostatic dressing with a non-hemostatic device. | 05-27-2010 |
20100143447 | WOUND OR TISSUE DRESSING COMPRISING LACTIC ACID BACTERIA - The present invention is directed to a wound or tissue dressing comprising a bacteria having the property of producing lactic acid from sugars by fermentation of the sugars. The bacteria preferably belongs to the family of lactic acid bacteria. The family of lactic acid bacteria refers to any bacteria belonging to a genus selected from the group consisting of | 06-10-2010 |
20100150989 | SUBSTRATES PROVIDING MULTIPLE RELEASES OF ACTIVE AGENTS - The present disclosure comprises a polymeric substrate that provides multiple releases of active agents. A substrate for multiple phase delivery of active agents is provided having a first polymer matrix layer having a first active agent disposed therein, a second polymer matrix layer having a second active agent disposed therein, and a coacervate layer disposed between the first polymer matrix layer and the second polymer matrix layer. Selected first and second active agents are included in the first and second polymer matrices such that as the first and second polymer matrices dissolve, the active agents are released. Multiple phase active agent release is achieved by constructing multiple layers of a polymer matrix containing an active agents formed with polymers having different solubility characteristics or with active agents at different concentration levels. | 06-17-2010 |
20100150990 | TREATMENT OF INFLAMMATION AND/OR ENDOTOXIC SHOCK - This invention provides the use of one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for treatment of inflammation and/or endotoxic shock and/or treatment of wounds and/or reduction of levels of inflammatory chemokines in a subject, and one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for use in the treatment of inflammation and/or endotoxic shock, and/or wounds, or for the reduction of levels of inflammatory mediators. | 06-17-2010 |
20100172958 | Wound dressing devices and methods - The present invention provides an absorbent wound dressing assembly that can be used to stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access. The wound dressing assembly is flexible so that it can be adapted and used to fit in narrow and small wound sites. Generally the wound dressing assembly comprises a flexible carrier material that is impregnated with a non-mammalian material for control of severe bleeding. The preferred non-mammalian material is poly [β-(1→4)-2-amino-2-deoxy-D-glucopyranose] more commonly referred to as chitosan. | 07-08-2010 |
20100183701 | Wound Dressings comprising hydrated hydrogels and enzymes - A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin. | 07-22-2010 |
20100196448 | WOUND HEALING DRESSING AND METHODS OF MANUFACTURING THE SAME - Disclosed are a hydrogel dressing for covering or treating a wound and a method for preparing the same. The hydrogel dressing includes a matrix structure of a cross-linked mixture, and an elastic sheet coated with an elementary metal or ionic metal embodied in the matrix structure. The mixture comprises a hydrophilic polymer, about 0.5 to about 5 wt % of a photocatalyst agent and at least 80 wt % of water based on the total weight of the mixture. | 08-05-2010 |
20100209481 | NEW WOUND DRESSING COMPOSITIONS - A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds. | 08-19-2010 |
20100209482 | DRESSING SECURING SYSTEM - A dressing securing system for securing a dressing relative to a wound, the dressing securing system comprising a fabric composed of a resilient knitted material. | 08-19-2010 |
20100215722 | Tissue Regeneration II - The invention relates to tissue regeneration and to therapeutic compositions, formulations and dressings. | 08-26-2010 |
20100221311 | Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering - Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration. | 09-02-2010 |
20100221312 | Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering - Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration. | 09-02-2010 |
20100233247 | Dressing Material Comprising Active Substances - The present invention relates to a dressing material comprising a support material and at least one active substance from in each case | 09-16-2010 |
20100247613 | Dressing Modified to Receive Medicine - A laminated dressing defining an area adapted to receive and hold medicine. In one embodiment of the invention, the dressing comprises a contact layer and a backing layer, both fabricated from absorbent materials. The contact layer has an inboard surface and an opposing outboard surface defined. The outboard surface of the contact layer is adapted to be applied to a patient's skin surrounding a wound. The contact layer further defines a die-cut through-opening substantially in the center of the contact layer. Adhering to the inboard surface of the contact layer is the backing layer, which likewise has an inboard surface and an opposing outboard surface defined. Medicine is received in the area defined by the through-opening in the contact layer and the inboard surface of the backing layer. A polymer film covers the outboard surface of the backing layer to prevent the escape of medicine from the dressing through the backing layer. A removable release film covers the adhesive-covered outboard surface of the contact layer, the reception area and the medicine until the dressing is ready to be used. | 09-30-2010 |
20100247614 | HEMOSTATIC WOUND DRESSING - Hemostatic wound dressings that include cationic polymers and related hydrogels, methods for making and using the wound dressings. | 09-30-2010 |
20100255070 | COMPOSITIONS AND METHODS FOR PREVENTING, MINIMIZING AND HEALING SKIN IRRITATION AND TRAUMA - A composition for preventing, mitigating, and alleviating irritation and skin trauma is described. The composition contains calcium glycerophosphate and at least one skin compatible, film-forming component. The composition may be applied to the skin prior to application of an adhesive tape to reduce damage to the skin which is inflicted upon removal of the tape by forming a film on the skin. Upon removal of the adhesive tape from the skin, the film, rather than skin cells, is removed with the tape. The calcium glycerophosphate component of the composition also penetrates the skin and serves to alleviate any damage which may be inflicted on the skin. The composition may also be applied to the skin to prevent subsequent irritation, such as irritation inflicted by contact with poison ivy, clothing, jewelry, insect bites, a prosthetic, etc. A medical dressing which contains the composition is also included. Finally, methods for preventing and mitigating skin irritation and trauma using the inventive composition are described. | 10-07-2010 |
20100260823 | PREPARATION WITH MARINE COLLAGEN FOR PROTEASE INHIBITION - The invention relates to pharmaceutical preparations made from marine collagens for inhibiting matrix metalloproteases and the use of a marine collagen for production of a pharmaceutical preparation for inhibiting matrix metalloproteases. | 10-14-2010 |
20100285100 | COMPOSITIONS AND MEDICAL DEVICES FOR CONTROLLED RELEASE OF NITRIC OXIDE AND METHODS OF PRODUCTION THEREOF - The present disclosure describes compositions providing for controlled release of nitric oxide (NO) and methods for production of these compositions. In some embodiments, the compositions may include a biodegradable polymer and a nitric oxide-releasing material at least partially encapsulated by the biodegradable polymer. Nitric oxide-releasing materials may include, for example, diazeniumdiolates and nitric oxide contained within a zeolite, metal-organic framework or other porous material. In general, the compositions are spun into a porous fiber, which may be further annealed by heating in order to densify the fiber. Annealing may prolong the NO release profile. Medical devices containing the compositions described herein are also contemplated by the present disclosure. Medical devices include, for example, textiles, bandages and articles of clothing. | 11-11-2010 |
20100285101 | COMPOSITE NONWOVEN FIBROUS WEBS AND METHODS OF MAKING AND USING THE SAME - The disclosure relates to composite nonwoven fibrous webs including a population of sub-micrometer fibers having a median diameter less than one micrometer (μm), and a population of microfibers having a median diameter of at least 1 μm. At least, one of the fiber populations is oriented, and each composite nonwoven fibrous web has a thickness and exhibits a Solidity of less than 10%. The disclosure also relates to methods of making composite nonwoven fibrous webs, and articles including composite nonwoven fibrous webs made according to the methods. In exemplary applications, the articles may be used as gas filtration articles, liquid filtration articles, sound absorption articles, surface cleaning articles, cellular growth support articles, drug delivery articles, personal hygiene articles, or wound dressing articles. | 11-11-2010 |
20100285102 | COLLOIDAL COLLAGEN BURN WOUND DRESSING PRODUCED FROM JELLYFISH - The present invention relates to methods of forming wound dressings from jellyfish collagen. A jellyfish tissue is provided, after which an acid is added to produce a collagen-salt solution. The solution is mixed to form a viscous colloidal gel, and a film or a film/fabric composite is created from the gel. | 11-11-2010 |
20100291184 | WOUND DRESSING WITH APERTURED COVER SHEET - A wound dressing comprising an antimicrobial absorbent layer containing silver, and an apertured sheet covering the antimicrobial absorbent layer, wherein the apertured sheet is formed from a liquid-impermeable sheet material having an array of apertures therein, said apertures having a mean effective diameter of from about 0.5 mm to about 2 mm, and wherein the percentage open area of the apertured sheet is from about 7% to about 25%. The selection of apertures in this range provides enhanced antimicrobial efficacy. | 11-18-2010 |
20100310633 | CHITINOSANASE - A chitinosanase obtainable from the fungus | 12-09-2010 |
20110027344 | Alginate-Containing Wound Dressing, Method and Apparatus for Making the Same - Disclosed herein is a wound dressing. The wound dressing includes a first fiber layer and a second fiber layer stacked on and bound to the first fiber layer. The first fiber layer consists of a plurality of a first fiber that are made of an alginate wherein the first fibers are respectively bound with one another, and are substantially extended in parallel along a first direction. The second fiber layer consists of a plurality of a second fiber that are made of an alginate, wherein the second fibers are respectively bound with one another, and extend in parallel along a second direction that is not parallel to the first direction. The second layer is stacked on the first layer with the second fibers being bound with the first fibers. The first fibers and the second fibers respectively have a length such that the wound dressing has a breaking strength for at least 1.5 kg. | 02-03-2011 |
20110033520 | Antimicrobial Nanostructured Hydrogel Web Containing Silver - Robust polymeric hydrogels and a method to fabricate antimicrobial non-woven fibrous wound dressing with controlled silver release that may be used for anti-infective medical implants and anti-infective coating for implantable medical device. The hydrogels may be provided in non-woven fibrous wound dressing and anti-infective implantable medical devices, especially for reconstructive oral and bone surgery. | 02-10-2011 |
20110038920 | WOUND HEALING COMPOSITIONS AND TREATMENTS - Methods and compositions comprising an anti-ostepontin agent and/or a PDGF receptor blocker or antagonist, alone or in combination with one or more anti-connexin agents, for example, one or more anti-connexin polynucleotides and/or one or more anti-connexin peptides or peptidomimetics, are provided for the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications. | 02-17-2011 |
20110038921 | METHODS AND COMPOSITIONS FOR TEMPORAL RELEASE OF AGENTS FROM A BIODEGRADABLE SCAFFOLD - The present invention provides methods and compositions for sequentially and separately reducing infection and/or inflammation and regenerating tissue at a lesion site, by contacting the lesion site with a biodegradable scaffold that first delivers one or more agents at the lesion site to reduce infection and/or inflammation and then delivers one or more agents to regenerate tissue at the lesion site after inflammation is reduced. | 02-17-2011 |
20110045056 | HYDROGEL CO-POLYMER COMPOSITION AND ITS USES, FOR EXAMPLE AS A WOUND DRESSING - The present invention provides a hydrogel composition, preferably for the treatment of wounds, comprising a hydrophilic co-polymer carrying multiple pendant anionic groups, wherein the polymer is derived from a first monomer and a second monomer, wherein both monomers have an octanohwater partition coefficient Log P value of less than 0, and, the Log P value of the first monomer is greater (more positive) than the second monomer. Preferably the difference between the Log P value for the two monomers is at least 0.1, preferably at least 0.2. The difference between the Log P value for the two monomers is preferably less than 2. The weight ratio (w/w) of the first monomer/second monomer in the hydrogel composition is preferably equal to or more than about 1. The pendant anionic groups may be sulphonyl groups, e.g. sulphonic acid groups or salts thereof. The anionic group in both first and second monomers may be in salt form and the counterion for both monomers is preferably the same. | 02-24-2011 |
20110052663 | Hemostatic Sponge with Enzyme and Method of Manufacture - In one embodiment, a method of making a wound dressing comprises dissolving at least one hemostatic agent in at least one solvent to form a solution. The method continues by freeze drying the solution to form a sponge. The method further comprises including an enzyme in the sponge that enables a human body to readily degrade the hemostatic agent. | 03-03-2011 |
20110052664 | Antimicrobial Medical Dressings and Protecting Wounds and Catheter Sites - An antimicrobial medical dressing provides a combination of antimicrobial agents in various concentrations that protect against microorganisms, absorb exudates, and promote healing. The antimicrobial agents may include compositions of ethanol, hydrogen peroxide, and/or ethylenediaminetetraacetic acid. | 03-03-2011 |
20110052665 | HAEMOSTATIC MATERIAL - The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures. | 03-03-2011 |
20110064786 | NOVEL USE OF BASIC FIBROBLAST GROWTH FACTOR IN THE DE-DIFFERENTIATION OF ANIMAL CONNECTIVE TISSUE CELLS - De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The de-differentiation protocols described herein comprise culturing the differentiated cells with an amount of FGF2 to de-differentiate the cells. These de-differentiated cells may then be cultured and used for experimentation, amplification and clinical applications. The clinical applications include the use of the cells for tissue and cell based therapies. | 03-17-2011 |
20110070288 | COMPOSITE LAYERED HEMOSTASIS DEVICE - The present invention is directed to a hemostatic composite structure having a bioabsorbable fabric or non-woven substrate having at least two major oppositely facing surface areas and a continuous non-porous polymer-based film that is laminated on one major surface of said substrate. The bioabsorbable fabric substrate can be an oxidized polysaccharide and/or the non-woven substrate can be made from bioabsorbable, non-cellulosic derived polymers. The continuous non-porous polymer based film can be a bioabsorbable polymer. The present invention also relates to a method for providing hemostasis by applying a composite structure described herein onto a wound site in need of a hemostatic device wherein a major surface of the substrate without the film layer is applied onto the wound site. | 03-24-2011 |
20110097383 | APPARATUS AND METHODS FOR ENZYMATIC ESCHAROTOMY IN BURN INDUCED COMPARTMENT SYNDROME - Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn. The apparatus includes a flexible, water-impermeable generally cylindrical covering layer. The covering layer has an inner surface facing the limb and an outer surface. The covering layer has a proximal sealable open end through which the burned limb is inserted and a distal closed end. An enzymatic escharotomy agent is contained within the covering layer. The covering layer retains the enzymatic escharotomy agent in close proximity to the burned limb, and the apparatus is enclosed within a sterile sealed package evacuated from moisture. In use, the burned limb is enclosed within the apparatus, and the enzymatic escharotomy agent is activated in situ by contacting the agent with hydrating fluid, thereby inducing enzymatic escharotomy of the circumferential burn. | 04-28-2011 |
20110111012 | Nanomaterial wound dressing assembly - Wound dressing assemblies and methods of producing the wound dressing assemblies. The wound dressing assemblies various comprise individual layers of nanomaterials that have been formed according to an electrospinning process. | 05-12-2011 |
20110117178 | WOUND DRESSING COMPRISING A HYDROGEL MATRIX - The present invention relates to a multilayered wound dressing particularly for wound treatment in the granulation and epithelization phase. The wound dressing comprises
| 05-19-2011 |
20110123597 | Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering - Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration. | 05-26-2011 |
20110142910 | Clotting and Healing Compositions Containing Keratin Biomaterials - Disclosed are optimized keratin preparations for use in medical applications. Methods to produce optimized keratin preparations are provided for use in biomedical applications, particularly for the treatment of bleeding, and for the treatment of wounds. Also disclosed are surgical or paramedic aids comprising a substrate with keratin preparations provided thereon, and kits comprising keratin derivatives packaged in sterile form. | 06-16-2011 |
20110165221 | WOUND CARE - A method for treating a wound, and a dressing for wound care management comprising a three-dimensional body of glass-based fibers comprising one or more glass-formers selected from the group consisting of P | 07-07-2011 |
20110171283 | COMPOSITION CONTAINING AT LEAST ONE NUTRIVITE, AT LEAST ONE DISINFECTING OR DECONTAMINATING, AND/OR AT LEAST ONE PROTEASE-INHIBITING ACTIVE COMPOUND AND/OR ACTIVE COMPOUND COMPLEX - The present invention relates to a composition containing at least one nutritive, at least one disinfecting or decontaminating and/or at least one protease-inhibiting active compound and/or active compound complex for the external care and/or treatment of wounds of the human or animal body. | 07-14-2011 |
20110171284 | POVIDONE-IODINE AND SUCROSE WOUND HEALING DRESSING - The present invention relates to a composition and wound dressing for delivering a composition comprising povidone-iodine and sucrose mixture. The composition is gelled and, in one embodiment, is impregnated on a gauze or other like material for application to an exuding or non-exuding wound. | 07-14-2011 |
20110182970 | Nitric oxide sensors and systems - The present disclosure relates to nitric oxide sensors and systems. | 07-28-2011 |
20110217358 | COMPOSITIONS FOR THE PROPHYLAXIS AND TREATMENT OF DERMATOLOGICAL/MUCOSAL DISEASES, AND USES THEREOF - The present invention provides a composition containing a) clay material with a negative surface charge; b) magnesium ions and calcium ions both either incorporated within the clay material and/or added separately; c) water and/or non-aqueous solvent; d) substantially non-cationic carrier; where i) the mean particle size of the clay material is at least 5 nm; and ii) the total molar amount of magnesium ions is higher than the total molar amount of calcium ions. The present invention further relates to the use of said composition in the manufacture of a medicament for the prophylaxis and treatment of skin diseases, skin conditions, or mucosal diseases where the formation and/or recovery of epidermal/mucosal barrier function has beneficial effects. | 09-08-2011 |
20110217359 | PHARMACEUTICAL COMPOSITION FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF DECUBITI AND FIRST DEGREE BURNS AND TREATMENT METHOD - This invention relates to a pharmaceutical composition and method for preventing and treating decubitus by topical administration of a therapeutic dosage of a composition containing an antioxidant agent, an anesthetic and vasodilating agent, and an antifungal agent emulsified in a pharmaceutically acceptable carrier. | 09-08-2011 |
20110217360 | OCTENIDINE COMPOSITION - The invention relates to octenidine or a pharmaceutical salt thereof, in particular octenidine dihydrochloride, which is intended for mutual therapeutic administration of the octenidine in solution with a polyalcohol of formula 1: (H—C—OH) | 09-08-2011 |
20110274744 | PROCESS FOR PREPARING A SURFACE COATED BY CROSSLINKED POLYELECTROLYTE MULTILAYER FILMS AS A BIOMIMETIC RESERVOIR FOR PROTEINS - The invention relates to processes for coating a surface with a crosslinked polyelectrolytes multilayer film incorporating a protein, preferably a growth factor type protein. The invention also relates to crosslinked polyelectrolytes multilayer films obtained by this process, and a coated surface obtained therefrom. | 11-10-2011 |
20110280926 | WOUND DRESSING - The present invention relates to a multilayered wound dressing particularly for wound treatment in the granulation and epithelization phase. The wound dressing comprises
| 11-17-2011 |
20110280927 | COMPOSITION AND DRESSING WITH NITRIC OXIDE - A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydrocolloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer. | 11-17-2011 |
20110280928 | Wound Care Device Having Fluid Transfer Properties - This disclosure relates to wound care devices which are capable of one-way, directional flow of fluids and contaminants away from the wound site to the opposite side of the wound care device, which functions as a fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess fluid, and potentially even bacteria, and is carried out without loss of physical integrity of the wound care device itself. In addition to providing a uni-directional fluid transport mechanism, the wound care device may contain a topically applied silver-based antimicrobial finish which provides certain levels of antimicrobial agent to the wound in order to clear infection from the wound site and control bacterial growth in the wound care dressing. Exemplary topical antimicrobial finishes include silver ion-releasing compounds. | 11-17-2011 |
20110305745 | Pollulan regenerative matrix - Compositions and methods are provided for the manufacture and use of a pullulan-based collagen hydrogel film with controlled porosity. The hydrogel is fabricated with salt-induced phase inversion and cross-linking to form a reticular scaffold. This soft collagen scaffold displays excellent handling characteristics, durability, and a porous dermal-like ultrastructure that is maintained in vitro. Cells, including cells involved in tissue repair, are viably sustained within the scaffold. The hydrogel films are biodegradable, and find particular use in wound healing, where the hydrogel scaffold can be replaced by dermal cells over time. | 12-15-2011 |
20110311610 | TEMPERATURE REDUCING, HEALING WOUND DRESSING - The present invention relates to wound dressings having a wound contacting layer that contains a wound healing composition and which is adapted to maintain a temperature different from ambient, for example achieve and maintain a heat-absorbing effect on the underlying tissues. The specific physico-chemical structure of the devices of the invention allows fluid containment and absorption of wound secretions whilst avoiding skin macerations. | 12-22-2011 |
20110318404 | Wound Dressing, Methods and Apparatus For Making Same and Storage and Use Thereof - Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury. | 12-29-2011 |
20120003293 | NITRIC OXIDE-RELEASING DRESSINGS - A wound dressing comprising nitric oxide gas producing component. | 01-05-2012 |
20120009241 | SKIN WOUND DRESSING AND PREPARING METHOD THEREOF - A skin wound dressing is disclosed. The skin wound dressing comprises Tremella polysaccharide and alginate and is used to cover on a skin wound to accelerate wound healing. The Tremella polysaccharide is isolated from a hot water extract of | 01-12-2012 |
20120064145 | WOUND DRESSING - The present invention discloses a wound dressing which may be a double-layer wound dressing, comprising a polymer material layer in combination with anti-infective antibiotics or anti-infective Chinese herb medicine at the upper layer of the wound dressing, and a porous carbon material layer capable of loading with skin-associated epithelial cells at the lower layer of the wound dressing. The wound dressing with the antibiotics can block effectively the invasion of bacteria in the external environment, thereby preventing the wound from secondary infection. While covering the wound site, the porous carbon material layer with the epithelial cells can thus provide the healthy epithelial cells and attract the surrounding healthy cells to aggregate for secreting collagen so as to promote the wound healing process. According to the present invention, there is an obviously enhancing effect on wound tissue regeneration, restoration and healing, and there is a grant development potential in clinical applications. | 03-15-2012 |
20120107388 | HEMOSTATIC COMPOSITION, APPARATUS, AND METHODS - The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile ( | 05-03-2012 |
20120114737 | SILICONE ACRYLATE HYBRID COMPOSITION AND METHOD OF MAKING SAME - A silicone acrylate hybrid composition includes the reaction product of a silicon-containing pressure sensitive adhesive composition, an ethylenically unsaturated monomer, and an initiator. The silicon-containing pressure sensitive adhesive composition includes acrylate or methacrylate functionality. A method of making the hybrid composition includes polymerizing the ethylenically unsaturated monomer and the silicon-containing pressure sensitive adhesive composition in the presence of the initiator. | 05-10-2012 |
20120148657 | Lipoxygenase and Its Use in Wound Healing - In general, the present invention relates to epidermal lipoxygenase obtained from axolotl and pharmaceutical compositions containing the same. In particular, in a first aspect the present invention relates to pharmaceutical compositions containing lipoxygenase obtained from axolotl or functional homologues thereof having a lipoxygenase activity, in particular for use in wound healing, bone healing or conditioning of injured tissue, e.g. in wound dressings. In a further aspect, the present inventions relates to cosmetical compositions containing said lipoxygenase. Finally, the present invention provides methods for identifying modulators of wound healing, scarring, etc. comprising the step of determining compounds able to alterate the lipoxygenase enzyme activity. | 06-14-2012 |
20120177720 | MULTI-LAYER WOUND DRESSINGS - A wound dressing includes one or more layers containing a first anti-microbial agent and optionally at least one of: a chelating agent, a second anti-microbial agent, a zinc-containing agent, a cell-signaling agent, and an additional active ingredient or agent. | 07-12-2012 |
20120189685 | WOUND DRESSING COMPRISING AN ANTI-INFLAMMATORY PAIN-KILLING AGENT AND A COMPLEX OF SILVER ION AND A TRANSITIONAL ELEMENT OF GROUP IV OF THE PERIODIC SYSTEM OF ELEMENTS - A wound dressing comprising one or more absorbent elements capable of absorbing wound exudates, a non-steroid anti-inflammatory pain-killing agent and a complex of silver ion and a transitional element of group IV of the periodic system of elements. | 07-26-2012 |
20120213843 | COMPOSITION FOR PROMOTING WOUND HEALING - A lipid layer forming wound healing promoting composition comprising volatile silicone oil, polar lipid, C | 08-23-2012 |
20120231063 | DRESSING COMPRISING ACTIVE COMPONENTS OF CENTELLA ASIATICA AND USE OF THE SAME - Provided is a dressing, comprising (a) a substrate layer and (b) an active layer, which is a nanofiber layer and comprises: (b1) at least one of gelatin and collagen; (b2) polyvinyl alcohol (PVA); and (b3) at least one of asiaticoside and a | 09-13-2012 |
20120251612 | Wound Healing Device, Method for Making the Same and Method for Treating a Wound - A wound healing device includes a mat of aligned nanofibers of polyaniline, o-aminobenzenesulfonic acid copolymer, polyvinyl alcohol and chitsosan oligossacaride. Method for fabricating the mat and treating wounds are also disclosed. | 10-04-2012 |
20120269879 | COMPOSITIONS COMPRISING HONEY AND A SUPER- ABSORBENT MATERIAL - A composition comprising honey and a super-absorbent material. A method of treating a lesion comprising applying a composition comprising honey and a super-absorbent material to the lesion. A method of manufacturing the composition of the invention, comprising: (a) providing at least one type of honey; (b) providing at least one super-absorbent material; and (c) combining the honey and super-absorbent material. | 10-25-2012 |
20120282320 | Hemostatic dressing - The present invention relates to the preparation of a hemostatic dressing in the form of a powder that is particularly applicable for stemming severe bleeding and for incorporation of the powder into dressings that can stabilize the site of tissue injury, and simultaneously act as an antimicrobial agent. | 11-08-2012 |
20120282321 | Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering - Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration. | 11-08-2012 |
20120294927 | WOUND DRESSING - The invention relates to a sterile wound dressing having a backing and a nonabsorbent elastomer wound contact layer, wherein the elastomer matrix is formed by a synthetic three-block elastomer, preferably a copolymer of polystyrene block and polyolefin block (SEPS, SEBS, SEEPS, etc.) or mixtures thereof, wherein the total polymer content is less than 3.2 wt %, in particular 3.0 wt % or less, preferably 2.6 wt % or less, and is plasticized by an apolar oil and/or petroleum jelly. | 11-22-2012 |
20120294928 | METHOD OF TREATING SCARS AND B-CATENIN-MEDIATED DISORDERS USING NEFOPAM COMPOUNDS - Methods of treating disorders mediated by β-catenin comprising administration of Nefopam compounds are provided In particular, the treatment of disorders arising from excessive or undesired expression of β-catenin is contemplated Said compounds include Nefopam, analogues thereof, prodaigs thereof, and salts and solvates of Nefopam The β-catenin mediated disorders are preferably selected from the group consisting of fibroproliferative disorders (such as scars, aggressive fibramtoses, and fibroses) and cancer (such as colon cancer, melanoma, liver cancer, ovarian cancer, endometrial cancer, medullobalstoma pilomatricomas, and prostate cancer) | 11-22-2012 |
20120308636 | Multi-Layer Antimicrobial Wound Dressing - A multi-layer antimicrobial wound dressing includes a wound-contacting layer and an antimicrobial layer. The wound contacting layer includes a biocompatible fibrous matrix that is made of an anionic polymer, and the antimicrobial layer is made of a cationic polymer that is connected to the wound-contacting layer via anionic-cationic interaction between the anionic polymer of the fibrous matrix and the cationic polymer of the antimicrobial layer. | 12-06-2012 |
20120308637 | COMPOSITIONS COMPRISING EXTRACTS OF BOSWELLIA, TEA TREE, ALOE AND LAVENDER OIL AND METHODS OF TREATING WOUNDS, BURNS AND SKIN INJURIES THEREWITH - Compositions for the treatment of sores, wounds, burns and other traumatized dermal tissues and skin injuries comprising | 12-06-2012 |
20120308638 | ANTIMICROBIAL PEPTIDES - The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity. | 12-06-2012 |
20130017246 | Switchable AdhesivesAANM Tunius; MatsAACI GoteborgAACO SEAAGP Tunius; Mats Goteborg SE - The present invention provides switchable adhesives comprising a mixture, in proportions by weight, of 20% to 98% of an adhesive, 2% to 80% of curable molecules and 0.05% to 10% of photoinitiator in which the weight proportion of the adhesive is calculated on the basis of its dry weight and wherein the adhesive includes an internal cross-linker for cross-linking the adhesive during drying to provide a cohesive strength of between 5 and 100 N/12.7×12.7 mm measured according to FINAT test method No. 18. Preferably, the adhesive and curable molecules are mutually soluble when dry, or the curable molecules and adhesive may be uniformly dispersed in each other. Preferably the amount of adhesive in the mixture is in the range 40% to 98% by weight, more preferably 60% to 95% by weight, even more preferably 70% to 85% by weight. Preferably the proportion of curable molecules in the mixture ranges from 2% to 60% by weight, more preferably 5% to 40% by weight, even more preferably 15% to 30 by weight. Preferably, the photoinitiator is present in the mixture in the proportions 0.5% to 5% by weight, more preferably 1% to 3% by weight. Such switchable adhesives are useful in medical dressings and other removable sheet products, and may be simply prepared by stirring the adhesive, the curable molecules and the photoinitiator together at room temperature. | 01-17-2013 |
20130028954 | HEMOSTATIC DRESSING - The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue. | 01-31-2013 |
20130034596 | USE OF SYNTHETIC POLYSULPHATED OLIGOSACCHARIDES AS CLEANING AGENTS FOR A WOUND - The present invention relates to the use of at least one compound selected among the synthetic polysulphated oligosaccharides having 1 to 4 ose units and to the salts and complexes thereof as cleaning agents for a wound. The invention can be used in particular for preparing bandages intended for cleaning wounds. | 02-07-2013 |
20130039968 | MATERIALS AND PROCESSES FOR PRODUCING ANTITOXIC FABRICS - The invention provides a novel method of generating fabrics with outstanding antitoxic properties. The antitoxic properties are imparted to the fabric by introducing an active agent such as an antimicrobial or antiviral agent to the fabric. The active agent may be introduced into the fabric at multiple stages of the manufacturing process. For nonwoven fabrics, the active agent can be introduced during web formation and/or during post-processing steps. The fabrics produced in accordance with the present invention have widespread utility. For instance, they can be used as wound dressings, gowns, drapes, air filters, protective clothing and wipes. | 02-14-2013 |
20130045269 | FORMULATIONS AND METHODS FOR WOUND TREATMENT - The present application relates to formulations and methods for treating wounds, including chronic wounds. Suitably, the formulations comprise antibiotics and lawsonia inermis extract in various amounts. In embodiments, the formulations are formulated as sprays or gels that can be applied directly to the wound or to a wound dressing that is then applied to the wound. | 02-21-2013 |
20130064878 | WOUND HEALING COMPOSITIONS AND METHODS - The invention provides a method of accelerating the healing process of a skin or subdermal wound. The method can include administering to a mammal afflicted with a skin or subdermal wound an effective amount of a gelatinase inhibitor, or a pharmaceutically acceptable salt thereof, wherein the gelatinase inhibitor is effective to accelerate the healing process of the skin wound. The method is particularly effective when the mammal is suffering from diabetes. The gelatinase inhibitor can be topically administered, for example, in the form of a cream, gel, lotion, ointment, salve, or solution. | 03-14-2013 |
20130078300 | BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF - Novel bioabsorbable and/or biocompatible polyurethanes, polyureas, polyamideurethanes and polyureaurethanes with tunable physical, mechanical properties and hydrolytic degradation profiles are provided for use in biomedical applications such as stents, stent coatings, scaffolds, foams, and films. The disclosed polymers may be derived from biocompatible and/or bioabsorbable polyisocyanates. The present invention also relates to new and improved methods for the preparation of the biocompatible and/or bioabsorbable polyisocyanates. | 03-28-2013 |
20130084324 | ADHESION PREVENTION FABRIC - The present invention is directed to an adhesion prevention fabric having a first absorbable oxidized regenerated cellulose nonwoven fabric and a second absorbable oxidized regenerated cellulose woven or knitted fabric. Further disclosed is an adhesion prevention fabric that is useful for adhesion prevention in the presence of blood. | 04-04-2013 |
20130101661 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME - Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein. | 04-25-2013 |
20130108682 | WOUND CARE PRODUCT COMPRISING A CATHELICIDIN POLYPEPTIDE | 05-02-2013 |
20130108683 | COMPOSITIONS AND METHODS FOR TREATING PARTIAL AND FULL THICKNESS WOUNDS AND INJURIES | 05-02-2013 |
20130108684 | HEMOSTATIC COMPOSITION, APPARATUS, AND METHODS | 05-02-2013 |
20130136785 | ACTIVE SUBSTANCE-RELEASING WOUND DRESSING - The invention relates to a wound dressing, comprising a liquid-absorbing substrate having active substance depots contained therein, wherein the active substance depots comprise particles of at least one active substance which are encapsulated in a silicone shell. The invention further relates to a wound dressing according to the invention for use as a means for treating wounds and to the use of a wound dressing according to the invention for producing a means for treating wounds. | 05-30-2013 |
20130149368 | BIOCELLULOSE DRESSING AND METHOD FOR PREPARING THE SAME - A biocellulose dressing contains a high content of a humectant with superior absorbency and promotes wound healing. The biocellulose dressing contains 10-20% (w/w) of water, 5-30% (w/w) of a microbial cellulose and 50-80% (w/w) of a humectant. A method for preparing dressing is also disclosed. | 06-13-2013 |
20130156844 | METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS - The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications. | 06-20-2013 |
20130189346 | WOUND DRESSING - The instant disclosure relates to a wound dressing, which includes a plurality of hydrogel particles and a dressing. The hydrogel particles are granular colloids capable of absorbing and releasing the fluid, and the hydrogel particles are disposed to fill up the wound entirely. The dressing is covered on the wound to seal the hydrogel particles inside the wound. Thus, the wound dressing can maintain the appropriate balance of moisture in the wound environment to promote healing. | 07-25-2013 |
20130195958 | PROCESS FOR THE PRODUCTION OF PATCHES OR DERSSINGS OF AUTOLOGOUS SKIN THROUGH CULTIVATION OF AUTOLOGOUS KERATINOCYTES AND FIBROBLASTS WITH AUTOLOGOUS SERUM FOR THE GENERATION OF SKIN - The process in general is based on taking a sample of skin and a sample of blood from the patient and based on these two elements skin is cultured, being placed on a collagen patch to produce a dressing which is subsequently placed on the patient requiring same. | 08-01-2013 |
20130243847 | ACTIVATED CREATININE AND PRECURSORS THEREOF AS ANTIBACTERIAL AGENTS, COMPOSITIONS AND PRODUCTS CONTAINING SUCH AGENTS AND USE THEREOF - Creatinine, creatinine precursors or the pharmaceutically acceptable salts thereof are activated to function as an antibacterial agent which has broad spectrum activity and is beneficially used in a variety of applications, such as antimicrobial wound dressings, compositions for topical delivery of the antibacterial agent and for preventing and/or inhibiting the occurrence or spread of bacterial infection, as well as the growth of odor-causing bacteria, to name a few. | 09-19-2013 |
20130251782 | TOPICAL APPLICATION OF INGENOL MEBUTATE WITH OCCLUSION - The present invention relates to formulations of ingenol mebutate and methods of preparation and use thereof. More specifically, the invention relates to formulations of ingenol-3-mebutate applied to the skin with occlusion, and methods for treating or preventing diseases or conditions. | 09-26-2013 |
20130287837 | SOLID DRESSING FOR TREATING WOUNDED TISSUE - Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings. | 10-31-2013 |
20130315979 | Glucan Gels - The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×10 | 11-28-2013 |
20130330397 | Wound Care Products with Peracid Compositions - Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound. | 12-12-2013 |
20130337037 | HEMOSTATIC COMPOSITIONS AND THERAPEUTIC REGIMENS - The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to treat wounds. More specifically the present invention relates to hemostatic compositions that reduce the need for, and cost of, nursing care of patients with chronic wounds by reducing the frequency of wound dressing changes. | 12-19-2013 |
20130344129 | INFLAMMATION-REGULATING COMPOSITIONS AND METHODS - The various embodiments provide a composition that provides local control over inflammation. The composition localizes the activities of the cytokine-neutralizing antibodies to the site of inflammation through covalent attachment to hydrophilic matrices. The various embodiments including a hydrophilic polymer, a ligand binding moiety covalently attached to the polymer, and optionally, a cellular adhesion peptide covalently attached to the polymer. The hydrophilic polymer may be a glycosaminoglycan such as hyaluronan. The cellular adhesion peptide may be linear RGD peptide sequence covalently attached to the polymer. The ligand binding moiety may be a monoclonal antibody covalently attached to the polymer. The antibody may be selected from the group consisting of an anti-IL-1β, an anti-IL-6, an anti-TNF-α, and combinations thereof. The polymer functions as a substrate or matrix for cell migration and tissue regeneration. The RGD peptide functions to promote cellular proliferation, migration and attachment to the polymer. The monoclonal antibody functions to inhibit the inflammatory response. | 12-26-2013 |
20140044770 | Compositions and Methods for Modulating BRD4 Bioactivity - Compositions and methods for increasing or decreasing DNA repair are provided. Composition includes a Brd4 polypeptide, fragment, fusion, or variant thereof. The fusion protein can include a protein transduction, a targeting domain, or a combination thereof to enhance delivery of the fusion protein to the interior of a particular target cell, such as a cancer cell. Inhibitory nucleic acids that target a Brd4 mRNA and antibodies that target a Brd4 polypeptide are also disclosed. The inhibitory nucleic acid or antibody can target a sequence or epitope on Brd4 isoform B that is absent on Brd4 isoform A and Brd4 isoform C. Methods for increasing or decreasing the sensitivity of cells to a DNA damaging agent, methods of treating cancer, and methods of determining cells' sensitivity to a DNA damaging agent are also disclosed. | 02-13-2014 |
20140050774 | WOUND TREATMENT THERAPY - The wound treatment therapy deactivates pathogenic microorganisms within the wound environment without disrupting the cell walls. The wound treatment therapy of this invention combines the application of stabilized hypochlorous acid compound with the application of a hydrophobic wound dressing. The application of hypochlorous acid provides the initial anti-microbial agent, which disrupts and eradicates biofilm, as well as, deactivates the harmful pathogenic organisms within the wound environment. The application of the hydrophobic wound dressing, which is designed to bind harmful hydrophobic microorganisms and toxins, provides a mechanical vehicle for physically removing deactivated hydrophobic microorganisms form the wound environment with each dressing change. | 02-20-2014 |
20140056963 | EXTENDED PRODUCTION OF NITRIC OXIDE FROM A MICROENCAPSULATED NITRITE SALT AND AN AQUEOUS ACIDIFIED GEL - Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form | 02-27-2014 |
20140086976 | Compositions containing protein polymers and vaccinia virus, and methods of use thereof - Provided herein are compositions containing a vaccinia virus and a protein polymer, and articles of manufacture thereof. Also provided are diagnostic and therapeutic methods using the compositions or articles of manufacture. | 03-27-2014 |
20140086977 | TIGHT JUNCTIONS MODULATORS - The present invention relates to a new therapy targeted at the restoration or improvement of tight junction function. Aberrant TJ function, is characteristic of many chronic skin diseases. The inventors demonstrated that plant polyphenols or flavonoids and Cis-urocanic acid modulates tight junction structure and function in mammalian keratinocytes and provided tight junction modulators, pharmaceutical compositions and methods for preventing or treating impaired tight junction function in stratified mammalian epithelia. | 03-27-2014 |
20140099357 | Biologically Efficacious Compositions, Articles of Manufacture and Processes for Producing and/or Using Same - Compositions, solid polymeric compositions, and/or articles of manufacture are provided that can include a polymer matrix having a plurality of ion-exchange particles distributed therein. Products by process are provided that can include prior to solidifying the polymeric precursors, blending the precursors with ion-exchange particles to form a mixture, and solidifying the mixture to form a solid polymeric composition product. Solid polymeric composition production methods are also provided that can include providing a plurality of ion-exchange particles, prior to solidifying the polymeric precursors, blending the precursors with the ion-exchange particles to form a mixture, and solidifying the mixture to form a solid polymeric composition. Article of manufacture production methods are provided that can include incorporating a solid polymeric composition into an article of manufacture, the solid polymeric composition including a polymer matrix and a plurality of ion-exchange particles distributed therein. | 04-10-2014 |
20140112973 | BIOCOMPATIBLE AND BIODEGRADABLE GRADIENT LAYER SYSTEM FOR REGENERATIVE MEDICINE AND FOR TISSUE SUPPORT - The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same. | 04-24-2014 |
20140120153 | Methods and Compositions for Improved Delivery Devices - The present invention comprises methods and compositions for delivery devices More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment. | 05-01-2014 |
20140127283 | COMPOSITIONS COMPRISING HONEY AND A SUPER- ABSORBENT MATERIAL - A composition comprising honey and a super-absorbent material. A method of treating a lesion comprising applying a composition comprising honey and a super-absorbent material to the lesion. A method of manufacturing the composition of the invention, comprising: (a) providing at least one type of honey; (b) providing at least one super-absorbent material; and (c) combining the honey and super-absorbent material. | 05-08-2014 |
20140134229 | APPARATUSES, METHODS, AND COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF CHRONIC WOUNDS - According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a homogenous mixture, such as a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension or applied on a carrier material, such as a bandage, gauze, foam, sponge, hydrogel, hydrocolloid, hydrofiber, occlusive dressing, adhesive composition or scaffold. Methods for producing such a topical composition and carrier material with the topical composition applied thereto are also disclosed. | 05-15-2014 |
20140141057 | Adhesive or Hydrocolloid Containing Vegetable Oil - Various compositions including vegetable oil are described. The compositions also include either or both of an adhesive component and a hydrocolloid component. The vegetable oil imparts a skin-soothing property in the resulting compositions. The compositions can be used in a wide range of medical products and consumer healthcare goods. | 05-22-2014 |
20140141058 | USE OF OLIGOSACCHARIDE COMPOUNDS FOR THE PREVENTION AND TREATMENT OF PATHOLOGICAL SCARS - The present invention relates to a compound selected among the synthetic polysulphated oligosaccharides having 1 to 4 ose units and the salts and complexes thereof to be used for the treatment of wounds resulting in pathological scars selected among hypertrophic, retractile or atrophic scars. Said use is preferred in particular in patients that have a predisposition to developing hypertrophic, retractile or atrophic scars. According to a second aspect, the invention also relates to said compound for the use thereof in order to inhibit the differentiation of fibroblasts into myofibroblasts during the cicatrisation of wounds resulting in pathological scars selected among hypertrophic, retractile or atrophic scars. | 05-22-2014 |
20140220103 | HEMOSTATIC DRESSING FOR ARTERIAL BLEEDING - A wound treatment system having a formulation to retard bleeding. In particular, the wound treatment system includes medical device, e.g. bandage, which can be adapted for internal or external use. The wound treatment system includes a fabric substrate having a formulation, wherein the formulation includes chitosan, kaolin, fibrinogen, and thrombin. | 08-07-2014 |
20140242148 | ANTIMICROBIAL MATERIALS AND METHODS - The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products. | 08-28-2014 |
20140242149 | High-Viscosity Silicone Adhesive - Provided in various embodiments are high viscosity, shear-thinning silicone compositions that can be pattern coated directly onto a substrate and silicone compositions having high-density particles suspended in an adhesive gel. The silicone compositions contain a thixotropic additive, such as a hydrogenated vegetable oil. The silicone compositions may be applied on a substrate for use in medical devices or wound dressings. | 08-28-2014 |
20140271797 | Topical Copper Ion Treatments and Methods of Treatment Using Topical Copper Ion Treatments in the Dermatological Areas of the Body - Copper ion treatments for dermatological areas of the body include solutions, creams, lotions, gels, foams, wound dressings, skin patches and suture material, each containing copper ions that bring about therapeutic effects when the copper ion treatments are applied to dermatological tissue. Methods of treating dermatological areas of the body include treatments for use on the skin and nails to treat conditions including disease, infection, inflammation, damaged or injured tissue, tissue needing to be sutured, rashes and other undesirable dermatological conditions. | 09-18-2014 |
20140314830 | BACTERIALLY FORMED MICROCIN S, A NEW ANTIMICROBIAL PEPTIDE, EFFECTIVE AGAINST PATHOGENIC MICROORGANISMS, E.G. ENTEROHEMORRHAGIC ESCHERICHIA COLI (EHEC) - The present invention relates to a new isolated polypeptide nominated microcin S, isolated nucleic acid molecules encoding the microcin S polypeptide and primers and probes hybridizing to the nucleic acid molecules. The invention also relates to plasmids and cells comprising the nucleic acid molecules, an antibody binding to the polypeptide, compositions as well as methods for producing and using the polypeptides. The present invention further relates to medical uses for treating or preventing microbial infections, functional gastrointestinal disorders or treating a tumor. The invention further relates to a method for preserving food and a method for coating dressing material. | 10-23-2014 |
20140335149 | WOUND-HEALING PROMOTING MATERIAL - The object of the present invention is to provide a means for utilizing cells that have effects on wound healing as wound-healing promoting materials by efficiently concentrating such cells within a short period of time. The present invention provides a wound-healing promoting material which comprises a sheet-like porous body having on its surface at least leukocytes and/or platelets, a method for producing the same, a device for producing the same, and a method for treating wound sites using the same. | 11-13-2014 |
20140341969 | WOUND DRESSING - The invention relates to a sterile wound dressing having a backing and a nonabsorbent elastomer wound contact layer, wherein the elastomer matrix is formed by a synthetic three-block elastomer, preferably a copolymer of polystyrene block and polyolefin block (SEPS, SEBS, SEEPS, etc.) or mixtures thereof, wherein the total polymer content is less than 3.2 wt %, in particular 3.0 wt % or less, preferably 2.6 wt % or less, and is plasticized by an apolar oil and/or petroleum jelly. | 11-20-2014 |
20140377331 | ANTIMICROBIAL WOUND-COVERING MATERIAL AND METHOD FOR MANUFACTURING SAME - The present invention relates to an antimicrobial wound dressing comprising chitosan-silver nanoparticles and a preparation method thereof The antimicrobial wound dressing is prepared by coating a wound dressing with chitosan and silver and drying the coated wound dressing and has an excellent property of releasing silver nanoparticles in a sustained manner. | 12-25-2014 |
20150010612 | BIODEGRADABLE NON-WOVEN MATERIAL FOR MEDICAL PURPOSES - The invention relates to a biodegradable fleece containing (i) at least one polymer for inducing primary haemostasis, (ii) at least one non-proteinogenic, low-molecular, water-soluble activator of secondary haemostasis, and (iii) at least one non-proteinogenic, low-molecular, water-soluble inhibitor of fibrinolysis. The invention also relates to a method for producing a biodegradable fleece, in which (i) a fluidised fiber raw material, and additives if applicable, is placed in a container, (ii) the container is made to rotate, (iii) the fluidised fiber raw material is dispensed from the container by means of centrifugal forces, whereby fibers or filaments are formed, and (iv) a biodegradable fleece is produced from the fibers or filaments. The invention also relates to the use of said biodegradable fleece as a local haemostatic agent. | 01-08-2015 |
20150024029 | COMPOSITION AND DRESSING WITH NITRIC OXIDE - A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydrocolloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer. | 01-22-2015 |
20150030663 | NEW WOUND DRESSING COMPOSITIONS - A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds. | 01-29-2015 |
20150037392 | LIQUID-PERMEABLE PRIMARY DRESSING HAVING A FRACTION OF HEAVY METAL - The present invention relates to a fluid-permeable primary dressing in strip form, having pores, perforations or honeycomb lattices, which enable the passage of fluid, further having a content of at least one heavy metal present in elemental or ionic form. | 02-05-2015 |
20150044272 | WOUND DRESSINGS, METHODS AND APPARATUS FOR MAKING SAME AND STORAGE AND USE THEREOF - Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury. | 02-12-2015 |
20150071985 | HAEMOSTATIC WOUND DRESSING - Haemostatic wound dressings are described. The dressings comprise a non-colloidal porous dressing material, and a plurality of fibrinogen-binding peptides immobilised to the non-colloidal porous dressing material, wherein each fibrinogen-binding peptide comprises: an amino acid sequence Gly-Pro-Arg-Xaa (SEQ ID NO: 1) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Val, preferably Pro, Sar, or Leu; or an amino acid sequence Gly-His-Arg-Xaa (SEQ ID NO: 2) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Pro. The dressings are able to accelerate haemostasis without requiring enzymatic activity. In particular, the dressings to do not rely on the action of exogenous thrombin, and can be stored long-term at room temperature in solution. Methods of making the dressings, and use of the dressings to control bleeding are also described. | 03-12-2015 |
20150079152 | COMPOSITION AND DRESSING FOR WOUND TREATMENT - The invention provides methods and compositions for wound treatment and/or blood clot formation, e.g., arresting the flow of blood from an open wound. The methods and compositions provide for promoting and accelerating wound healing and optionally provide for inhibition of microbial infection and/or a local analgesic effect. | 03-19-2015 |
20150079153 | Cell Suspension and Use Thereof - The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. The cellular suspension can include viable and functioning cells at various stages of differentiation, including undifferentiated/progenitor cells and differentiated cells, as well as those in between. In certain embodiments, the cellular suspension can be subjected to a stress to induce a heat shock response therein, or be exposed to an exogenously supplied agent such as heat shock protein or a fragment thereof, hyaluronic acid, platelet-enriched plasma, and/or growth factors. The cellular suspension can be applied directly to a patient's recipient site for in vivo regeneration, or be cultured or seeded to a matrix for in vitro growth/regeneration. | 03-19-2015 |
20150098985 | WOUND DRESSINGS FOR THE CONTROLLED RELEASE OF THERAPEUTIC - A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme, wherein the activities of both the wound healing therapeutic agent and the inhibitor are increased by contacting the wound dressing material with a would fluid containing the protease enzyme. For example, the enzyme may be a matrix metalloproteinase, the therapeutic agent may be a reactive oxygen scavenger, and the inhibitor may be a tissue inhibitor of metalloproteinase (TIMP). | 04-09-2015 |
20150104496 | COMPOSITION CONTAINING AT LEAST ONE NUTRIVITE, AT LEAST ONE DISINFECTING OR DECONTAMINATING, AND/OR AT LEAST ONE PROTEASE-INHIBITING ACTIVE COMPOUND AND/OR ACTIVE COMPOUND COMPLEX - The present invention relates to a composition containing at least one nutritive, at least one disinfecting or decontaminating and/or at least one protease-inhibiting active compound and/or active compound complex for the external care and/or treatment of wounds of the human or animal body. | 04-16-2015 |
20150118283 | Wound Dressing with an Antimicrobial Effect - The invention relates to a wound dressing which is particularly suitable for therapeutically dressing wounds. Said wound dressing comprises at least one wound covering layer and at least one sorbent based on an activated carbon which has a biocidal and/or biostatic, in particular antimicrobial effect and/or finish. | 04-30-2015 |
20150118284 | SOLID DRESSING FOR TREATING WOUNDED TISSUE - Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue. | 04-30-2015 |
20150125512 | ANTIBACTERIAL SHEET MATERIAL THAT CAN BE USED AS A WOUND DRESSING AND METHOD FOR PRODUCING SAME - A sheet material that can be used as a wound dressing and contains elemental metal particles. | 05-07-2015 |
20150297661 | ANALGESIC COMPOSITIONS AND METHODS OF USE - The invention relates to the fields of pharmacology and medicine, and provides anesthetic compositions and methods for the treatment of pain using compositions comprising Tea tree oil and one or more additional agent. The invention relates to analgesic compositions for the treatment of pain associated with a variety of disorders or conditions, particularly oral or dental disorders or conditions such as alveolar osteitis or dental caries. | 10-22-2015 |
20150306274 | Haemostatic Material - The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures. | 10-29-2015 |
20150320826 | TREATMENT OF INFLAMMATION AND/OR ENDOTOXIC SHOCK - This invention provides the use of one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for treatment of inflammation and/or endotoxic shock and/or treatment of wounds and/or reduction of levels of inflammatory chemokines in a subject, and one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for use in the treatment of inflammation and/or endotoxic shock, and/or wounds, or for the reduction of levels of inflammatory mediators. | 11-12-2015 |
20150328284 | COMPOSITIONS AND METHODS COMPRISING TOLL LIKE RECEPTOR (TLR) STIMULATING AGENTS FOR PROPHYLAXIS AND THERAPY FOR DAMAGE TO DERMAL EPITHELIUM - Provided are compositions and methods for prophylaxis and/or therapy of dermal damage. The compositions and methods involve Toll like receptor (TLR) agonists that can inhibit the formation or accelerate healing of dermal damage, and/or inhibit inflammation at near the location of the dermal damage. The TLR agonists can be TLR2 and/or TLR5 agonists. The compositions and methods are suitable for prophylaxis and/or therapy of dermal damage caused by radiation, or non-radiation thermal injury such as burns caused by contact with heated surfaces or heated objects, light, and for disruptions in integument resulting in cuts, such as incisions, or punctures. The compositions can be used topically, subcutaneously or systemically. Articles of manufacture coated or impregnated with TLR agonist(s) are also provided. | 11-19-2015 |
20150352245 | METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES - Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings. | 12-10-2015 |
20150367019 | HEMOSTATIC COMPOSITIONS AND METHODS - Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques. | 12-24-2015 |
20160038442 | MATERIALS AND METHODS FOR CONTROLLING INFECTIONS WITH NEGATIVE PRESSURE WOUND THERAPY - The subject invention provides a method for promoting wound healing and preventing an infection or treating an existing infection with negative pressure wound therapy, said method comprising the steps of providing a sterile disinfectant composition comprising an active agent comprising chlorhexidine and administering the sterile disinfectant composition to the wound site prior to, during and/or following negative pressure wound therapy. The subject invention also provides a kit comprising the sterile disinfectant composition and, optionally, devices for administration of the sterile disinfection composition to the site with negative pressure wound therapy. | 02-11-2016 |
20160045635 | ANTI-MICROBIAL FOAMS CONTAINING POLYMER-STABILIZED SILVER NANOPARTICLES - An absorbent wound dressing comprises a hydrophilic porous substrate and polymer-stabilized silver nanoparticles distributed throughout the porous substrate. The silver nanoparticles have a particle size d | 02-18-2016 |
20160067290 | ENTEROCOCCUS FAECALIS BACTERIOPHAGE AND USES THEREOF - Bacteriophages are provided that infect strains of | 03-10-2016 |
20160082142 | Dressing System - The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain. | 03-24-2016 |
20160101207 | WOUND DRESSING COMPRISING AN ANTIMICROBIAL COMPOSITION - Methods, processes and compositions are provided for improved wound dressings comprising an antimicrobial composition. The wound dressings maintain conformability and strength, as well as antimicrobial performance, upon use after storage. | 04-14-2016 |
20160101210 | COMPOSITIONS COMPRISING HONEY AND A SUPER-ABSORBENT MATERIAL - A composition comprising honey and a super-absorbent material. A method of treating a lesion comprising applying a composition comprising honey and a super-absorbent material to the lesion. A method of manufacturing the composition of the invention, comprising: (a) providing at least one type of honey; (b) providing at least one super-absorbent material; and (c) combining the honey and super-absorbent material. | 04-14-2016 |
20160106878 | Wound Dressings and Applications Thereof - In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation. | 04-21-2016 |
20160106879 | ANTISEPTIC WOUND DRESSING - The invention relates to an antiseptic material, in particular as a wound dressing, containing a carrier material and at least one antiseptic together with a surfactant, wherein the carrier material is equipped with a cyclodextrin or cyclodextrin derivative that is loaded in the antiseptic or antiseptics. | 04-21-2016 |
20160113962 | GROWTH CONTROL OF ORAL AND SUPERFICIAL ORGANISMS USING GALLIUM COMPOUNDS - The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a gallium compound to an affected area. In particular, the present invention provides methods for treating or preventing dental caries, vaginal infections, skin infections, and so forth. Gallium compounds can be formulated as toothpaste, mouthwash, cream, ointment, gel, solution, eye drops, suppository, and the like. Furthermore, the invention provides methods for controlling microbial growth on environmental surfaces, including those of toothbrush, denture, dental retainer, contact lens, catheter, food stuff, and so forth. In addition, the present invention provides animal feeds which contain gallium compounds that promote the animal growth and prevent the animals from infections as well as protect consumers from post processing infections. | 04-28-2016 |
20160129049 | PURIFIED AMNIOTIC MEMBRANE COMPOSITIONS AND METHODS OF USE - Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases. | 05-12-2016 |
20160136323 | ANTIMICROBIAL HYDROCOLLOID DRESSING CONTAINING SEQUESTERED PEROXIDE AND PREPARATION THEREOF - This disclosure provides for an antimicrobial pressure sensitive adhesive composition that includes a sequestered peroxide source and devices that incorporate such a composition. | 05-19-2016 |
20160136328 | FENESTRATION KITS FOR MAKING FENESTRATED PLACENTAL TISSUE ALLOGRAFTS AND METHODS OF USING THE SAME - Described herein are fenestrated placental tissue allografts, methods for using the same for treating wounds that produce an exudate and to promote the healing process, and apparatus and kits for making the same that minimize or eliminate cross-contamination with placental tissue from other placental donors. | 05-19-2016 |
20160143944 | ANTIMICROBIAL COMPOSITIONS COMPRISING HYPOCHLOROUS ACID AND SILVER - The present invention relates to methods and compositions for treating a surface characterized by microbial infection or colonization. Particularly, the methods of the present invention involve applying a hypohalous acid (e.g., hypochlorous acid) composition and a silver additive. The present invention is useful, for example, in disinfecting or cleaning a mammalian tissue, such as a wound or burn, or disinfecting or cleaning a hard surface, such as a medical device. | 05-26-2016 |
20160151533 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | 06-02-2016 |
20160158403 | A WOUND DRESSING - The present invention relates to an impregnated wound dressing having an outer membrane overlay layer and to a method of production thereof. In particular the dressing comprises a core layer that has been impregnated with a wound healing agent, such as honey, and an outer membrane overlay layer. | 06-09-2016 |
20160166726 | NON ADHERENT HEALING INTERFACE AND ASSOCIATED COMPRESS AND DRESSING | 06-16-2016 |
20160193379 | HEMOSTATIC COMPOSITIONS AND THERAPEUTIC REGIMENS | 07-07-2016 |
20160199343 | COMPOUNDS AND FORMULATIONS FOR THE TREATMENT OF WOUNDS | 07-14-2016 |
20190142992 | ABSORBENT ALIPHATIC POLYURETHANE FOAM PRODUCT | 05-16-2019 |