Entries |
Document | Title | Date |
20080199513 | SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE - A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism. | 08-21-2008 |
20080213343 | Oral, Quickly Disintegrating Film, which Cannot be Spit Out, for an Antiemetic or Antimigraine Agent - Film-form, single-layered, cavity-free preparation free of surfactants, effervescent additive and taste masker and comprising one or more film former(s), one or more gel former(s) and one or more active ingredient(s) from the group of anti-emetics and anti-migraine agents. | 09-04-2008 |
20080220053 | Process for the Preparation of Two and Three Dimensional Polymer Scaffolds - A process for the preparation of polymer scaffolds containing a pharmacologically and/or biologically active protein molecule involving the following steps: neutralisation of the scaffold with a basic substance or a buffer solution; drying the scaffold; imbibition of the scaffold with a predefined quantity of a pharmacologically and/or biologically active protein molecule. | 09-11-2008 |
20080220054 | MODULATION OF DRUG RELEASE RATE FROM ELECTROSPUN FIBERS - Disclosed are co-electrospun polymeric fibers comprising polymers comprising pharmaceutically active agents and/or biologically active agents and capable of release at a combined release rate. Also disclosed are processes for preparing polymeric fibers capable of release at a combined release rate. Also disclosed are processes of modulating delivery rate of pharmaceutically active agents and/or biologically active agents. Also disclosed are processes of delivering pharmaceutically active agents and/or biologically active agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-11-2008 |
20080233176 | HAEMOSTATIC COMPOSITION AND METHOD - The invention relates to a composition comprising: (a) one or more aminoacids selected from glycine, proline and hydroxyproline; (b) a source of calcium ions; and (c) water. The invention also extends to a dry composition comprising the aforementioned components (a) and (b). The compositions of the invention are useful for arresting bleeding of humans and other animals, in particular for accelerating haemostasis at the site of incisions made during surgical procedures. | 09-25-2008 |
20080241228 | Polypeptide Films and Methods - Disclosed herein are polypeptide multilayer films comprising a hybrid polypeptide comprising a first polypeptide segment and a second segment, the two segments being covalently joined by one or more non-peptidic linkages. The first segment comprises a polypeptide having a magnitude of net charge per residue of greater than or equal to 0.4, and a length of greater than or equal to about 12 amino acid residues. The second segment comprises a polypeptide or another polyelectrolyte. | 10-02-2008 |
20080260806 | Personal hygiene compositions and methods - A personal hygiene composition, which may be coated on a towelette, comprises an astringent, a humectant, and a botanical extract. In some embodiments, the botanical extract can be selected from the group consisting of | 10-23-2008 |
20080260807 | Water-Soluble Films Comprising Nicotine - A water-soluble film comprising nicotine, wherein said nicotine may be any pharmacologically effective form of nicotine present at one or more locations of the film defined by the application of a nicotine-containing fluid to at least one surface of a preformed water-soluble film. | 10-23-2008 |
20080260808 | DEVICE FOR SMOOTHING WRINKLES ON HUMAN SKIN - Device for smoothing wrinkles on human skin and for enabling skin sections between successive wrinkles to achieve prolonged contact with cosmetic and/or pharmaceutical substances carried by said device. | 10-23-2008 |
20080260809 | POLYETHYLENE OXIDE-BASED FILMS AND DRUG DELIVERY SYSTEMS MADE THEREFROM - The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. | 10-23-2008 |
20080286342 | Form of Administration Based on Crosslinked Hydrophilic Polymers - The invention relates to a film-shaped form of administration for topically administering at least one agent and/or nutrient to a living being. Said form of administration comprises at least one agent-containing and/or nutrient-containing layer that is based on crosslinked hydrophilic polymers which are crosslinked with at least one polyacrylic acid derivative. | 11-20-2008 |
20080286343 | Solid form - A solid form comprising at least one film enrobing a compacted fill material having at least one active material contained in a matrix and having low friability, a density of at least 0.5 g/ml based on the total solid volume of the solid form and a tensile strength less than 0.9 MPa and which exhibits a controlled release profile for release of the active material. Zero order release may be achieved. | 11-20-2008 |
20080286344 | Solid form - A solid form comprising at least one film enrobing a compacted fill material wherein:
| 11-20-2008 |
20080292682 | METHOD FOR TREATING ALLERGIC DERMATITIS - A method for treating oleoresin induced allergic dermatitis by topically contacting an affected area with a therapeutically effective amount of one or more biopolymers for a sufficient amount of time to enable the one or more biopolymers to have an effect and removing the one or more biopolymers from the affected area. The oleoresin can be urushiol, isosolenopsin A, or a combination thereof. The one or more biopolymer can be albumin. The one or more biopolymers can provide a localized anti-inflammatory effect. | 11-27-2008 |
20080292683 | Film shreds and delivery system incorporating same - Compositions are provided that include water soluble or water dispersible film shreds, a carrier and an active, such as, but not limited to a drug, flavoring agent or coloring agent. Also provided are methods of use of the film shreds, such as in improving the dissolution, stability, aesthetics, or taste of a composition or its components, and in reducing a disease risk associated with an active. | 11-27-2008 |
20080299182 | METHODS AND FORMULATIONS FOR TOPICAL GENE THERAPY - Formulations of viral vectors for topical application are disclosed as well as methods for making the same. Also disclosed are methods of treating a subject or diagnosing disease in a subject using the formulations of the present invention. | 12-04-2008 |
20080305152 | Methods of Inducing Melanogenesis in a Subject - Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-MSH analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors. | 12-11-2008 |
20080305153 | Antibacterial Sol-Gel Coating Solution, Method for Preparing Antibacterial Sol-Gel Coating Solution, Antibacterial Articles, and Method and Equipments for Preparing Antibacterial Articles - The invention relates to an antibacterial sol-gel coating solution, a process for preparing the antibacterial sol-gel coating solution, an antibacterial article, and a process and an apparatus for producing the antibacterial article. Said antibacterial sol-gel coating solution comprises a. at least one substance selected from the group consisting of Ti or Si-containing compounds capable of hydrolyzing to form a base film; b. a regulating agent capable of regulating the hydrolysis rate of the Ti or Si-containing compounds; c. an organic solvent; d. water; and e. at least one soluble compound of antibacterial metal selected from the group consisting of Ag, Cu, Mg, Zn, Sn, Fe, Co, Ni, and Ce; wherein a, b and a portion of c are first mixed to form a solution I, d and the rest of c are then mixed and added into solution I to form a dispersion II, and then e is added into dispersion II to form the antibacterial sol-gel coating solution. | 12-11-2008 |
20080311176 | Drug Condensation Aerosols And Kits - The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits. | 12-18-2008 |
20080311177 | Self Assembled Films for Protein and Drug Delivery Applications - Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. In some embodiments, decomposable thin films and methods of using such films allow proteins to be released over an extended period of time and/or retention of as much as 100% of function of released protein. | 12-18-2008 |
20080317826 | POROUS KERATIN CONSTRUCTS, WOUND HEALING ASSEMBLIES AND METHODS USING THE SAME - A porous keratin construct for use in wound healing is disclosed. The porous keratin construct may be used standing alone or in combination with a synthetic foam backing layer. Either the porous keratin construct or the porous keratin construct and synthetic foam combination may be used in a wound therapy such as negative pressure wound therapy. An assembly for use in negative pressure wound therapy may comprise a porous keratin construct or porous keratin construct and synthetic foam combination, a wound drape to encapsulate the wound and the porous keratin construct or porous keratin construct and synthetic foam combination, and a vacuum source in fluid communication with the wound drape to apply a negative pressure to the area encapsulated by the wound drape | 12-25-2008 |
20080317827 | Methods and Devices for Delivering Therapeutic Agents to Target Vessels - Methods of preparing devices for delivering at least one therapeutic agent to a target vessel in a mammal, the devices prepared by such methods, and uses of such devices for delivering a therapeutic agent, such as an antiproliferative agent, to a target vessel. | 12-25-2008 |
20080317828 | Fentanyl compound-containing edible patch to be applied to oral mucosa - There is provided a film-type edible oral mucosal patch comprising a main ingredient, a fentanyl compound, contained in a base comprising (A) a semi-synthetic water-insoluble polymer compound, (B) a semi-synthetic water-soluble polymer compound, (C) a synthetic water-soluble polymer compound, (D) a water-soluble polyhydric alcohol and (E) a pH-adjusting agent. The oral mucosal patch consists of substances accepted as the food additives or pharmaceutical additives approved for oral administration, and is industrially efficiently produced and easily and safely used. | 12-25-2008 |
20090004252 | Skin Coating Composition and Uses Thereof - The present invention relates to a composition for coating the skin wherein the composition forms a water-proof flexible film on the skin. Preferably, the flexible film is durable and is capable of remaining adhered to the skin for 1 to 3 days. The composition may include (i) one or more pigments and/or dyes, or (ii) one or more sunscreen agents or (iii) one or more therapeutic agents for preventing or treating disorders of the skin. The coating composition comprises resin and flexibilizer (platicizer). Any suitable type of natural or synthetic resin may be used, preferably the resin is shellac or other natural gum derivative. A suitable flexiblizer is an animal, vegetable, mineral or synthetic oil, preferably castor oil, pine oil, rosehip oil or soya bean oil or mixture thereof. The composition optionally includes a diluent such as ethanol, a cellulosic preparation such as ethyl cellulose, an anti-agglomerating or dispersing agent and a thickener. The composition may be in the form of a paste, cream, gel, liquid or aerosol and may be used as a bandage or artificial skin. | 01-01-2009 |
20090004253 | Composite device for the repair or regeneration of tissue - The present invention is directed to composite devices comprising a tissue-engineering scaffold and an anionic polysaccharide/structural protein coating. The composite devices are useful for the reparation and regeneration of tissue, particularly in the treatment of chronic wounds. | 01-01-2009 |
20090022778 | EXTERNAL PLASTER CONTAINING FLURBIPROFEN - In a plaster for external use for transdermal absorption in which an adhesive layer is laminated on a plastic backing, the adhesive layer contains a styrene-isoprene-styrene block copolymer (SIS), a tackifying resin and a softener which are essential ingredients, and further contains flurbiprofen blended as an active ingredient. The present plaster for external use is a flurbiprofen containing plaster for external use enabling long-term stable release of contained flurbiprofen, and having excellent stability and very high drug releasing property. | 01-22-2009 |
20090028925 | Novel Phosphinic Acid-Containing Thyromimetics - The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes. | 01-29-2009 |
20090047328 | CAFFEINE DELIVERY SYSTEMS - Described are caffeine-based delivery vehicles. A first delivery vehicle is a malleable strip that dissolves in an oral cavity. Buccal absorption provides a prompt mental and physical stimulation for the user. The strips are formulated with beneficial ingredients comprising caffeine, taurine and/or nitric oxide. The strips are contained in a small crush-proof package for convenience. A second delivery vehicle is a gel. The gel provides a prompt and sustained effect. The sustained effect based on gastric absorption of ingested gel that does not absorb through contact with a user's oral cavity. A high viscosity of the gel enhances the buccal absorption. Like the strips, the gel is formulated with beneficial ingredients comprising caffeine, taurine and/or nitric oxide. The gel is contained in packages having an integrated, re-sealable straw. | 02-19-2009 |
20090047329 | MESOCELLULAR OXIDE FOAMS AS HEMOSTATIC COMPOSITIONS AND METHODS OF USE - The present invention relates to hemostatic compositions comprising a mesocellular oxide foam and, optionally, a biologically active agent such as a procoagulant, as well as devices and methods of use to promote blood clotting. | 02-19-2009 |
20090053285 | Medicament Carrier Composition and Method Of Forming A Film Therefrom - A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250 C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film. | 02-26-2009 |
20090053286 | PRODUCTS AND METHODS FOR MAINTAINING OR INCREASING CERAMIDE LEVELS IN SKIN - Disclosed are methods and products such as wet wipes and absorbents capable of providing a skin health benefit when utilized in the intended fashion. More specifically, the products described herein comprise an agent, such as a botanical extract, which is capable of increasing the activity of sphingomyelinase according to a Sphingomyelinase Activity Screening Test and/or decreasing the activity of ceramidase according to a Ceramidase Activity Screening Test. By increasing the activity of sphingomyelinase and/or decreasing the activity of ceramidase, the agents in combination with the products described herein are able to maintain or increase the level of ceramides in the skin leading to improved skin health. | 02-26-2009 |
20090060984 | ANIONIC SURFACTANTS LETHAL TO GRAM-POSITIVE BACTERIA - Disclosed are surfactant compounds and compositions that are antimicrobial. Also provided are polymeric compositions incorporating the surfactant compounds. The polymeric compositions may be used to form antibacterial coatings on surfaces. | 03-05-2009 |
20090074841 | Medicament-based patch - A medicament-based patch comprises a release paper on the surface of a patch carrier, being defined to, from right to left, a first tear-down slice, a second tear-down slice, and a third tear-down slice. Each tear-down-slice correspondingly matches with an adjacent edge of another teardown slice through joints of concaves and convexes. A plurality of convex unit margins correspondingly matching with concave unit margins, and concave unit margins correspondingly matching with convex unit margins are respectively formed in an area where the second teardown slice is close to the adjacent edges of the first tear-down slice and third tear-down slice, so the two identical concave or convex margins are not symmetrical to make the release paper stably and securely adhere to a carrier. For the functional effect of a product, the curve is unlikely complicated to make a trouble to a user in tearing down a medicament-based patch. | 03-19-2009 |
20090074842 | Medicament patch - A medicament patch comprises a release paper that oppositely lies on the surface of a patch carrier. The release paper is defined to, from right to left, a first teardown slice, a second teardown slice, and a third teardown slice. Each teardown-slice correspondingly matches with an adjacent edge of another teardown slice through joints of concaves and convexes. A radian that is inwards depressed by degree is formed where the second teardown slice is close to the adjacent edges of the first teardown slice and third teardown slice. A curve is then formed to make the release paper stably and securely adhere to a carrier. However, for the functional effect of a product, the curve is unlikely complicated to make a trouble to a user in tearing down a medicament patch. | 03-19-2009 |
20090087475 | Non-Wovens With High Interfacial Pore Size And Method Of Making Same - A Nonwoven fibrous structures with a high interfacial pore size and substrates made therefrom are provided. The substrates may be used, for example, in wipes. In one embodiment, the wipes include a hydromolded pattern on one side. The hydromolded pattern has an average pore-size of the interface between two stacked wipes that is greater than 180 microns in radius. In addition, a method for manufacturing nonwoven fibrous structures with high interfacial pore size is also provided. | 04-02-2009 |
20090098190 | Use of Lactobacillus for Increasing the Absorption of a Metal Chosen From Fe, Zn, Ca and Ions Thereof - The present invention relates to the use of at least one strain of | 04-16-2009 |
20090098191 | Use of bases to stabilize transdermal formulations - Stabilized transdermal acid sensitive drug formulations and their associated methods of production and use are described. The formulations containing acid sensitive drugs can also an acrylic adhesive, and a pharmaceutically acceptable base. The formulations can further contain other adhesives, permeation enhancers, and other stabilizing compounds such as free radical inhibitors. | 04-16-2009 |
20090117173 | Antimicrobial glaze and poreclain enamel via double layer glaze with high zinc content - A cost-effective and practical antimicrobial glaze system and glazing process is disclosed herein. The antimicrobial glaze/enamel may comprise at least two layers: a base layer and a top layer. The base layer may contain a typical or normal glaze widely used in sanitary ware, having a low level of zinc oxide. The base layer glaze may be directly sprayed on the clay body surface. A thin top glaze layer is sprayed on top of the base glaze layer and the top layer may contain a high level of zinc oxide. | 05-07-2009 |
20090117174 | MODIFIED SORBITAN SILOXANE COMPOSITIONS AND USE THEREOF - The present disclosure generally relates to personal care compositions and wipes. More particularly, the disclosure relates to compositions and wipes for imparting a perceivable aesthetic feel to the skin of a user. To achieve the perceivable aesthetic feel, a modified sorbitan siloxane is incorporated into the compositions and wipes. | 05-07-2009 |
20090123525 | Adsorbent-Containing Hemostatic Devices - The present invention utilizes a combination of a porous carrier and an adsorbent such as a molecular sieve to make a more effective hemostatic device to treat wounds in mammalian animals. These hemostatic devices contain additives that do not inhibit hemostasis. | 05-14-2009 |
20090130180 | Preparation for External Use - A preparation for external use which, even when ingredients such as a drug, absorption accelerator, and plasticizer are contained therein in a large amount, is excellent in pressure-sensitive adhesive properties including cohesive force and which, when a drug is contained therein, enables the drug to have excellent percutaneous absorbability. The preparation for external use includes a pressure-sensitive-adhesive matrix layer, wherein the pressure-sensitive-adhesive matrix layer comprises a pressure-sensitive adhesive base comprising a hydroxylated polymer, a boron compound, and silicic acid. | 05-21-2009 |
20090130181 | Antibacterial Surface Treatments Based on Silver Cluster Deposition - Process to obtain antibacterial surfaces by silver deposition in the form of firmly bonded small particles and to the antibacterial substances obtained by aforementioned treatments. Silver deposition is obtained by surface impregnation of natural or synthetic material in an alcoholic solution with silver salt and, later, by their exposure to UV-rays until metal silver clusters form as a result of silver ions reduction on the material surface. The invention relates to the obtained antibacterial substances. | 05-21-2009 |
20090130182 | TOPICAL COMPOSITIONS FOR TREATING PAIN - Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness. | 05-21-2009 |
20090130183 | Bilayer Composition for the Sustained Release of Acetaminophen and Tramadol - The invention relates to a bilayer composition for the delivery of acetaminophen and tramadol over at least a twelve hour period following initial administration. A single administration of the bilayer composition can provide analgesia starting in less than half an hour to about one hour after initial administration with a duration of at least twelve hours after initial administration. | 05-21-2009 |
20090130184 | COMPOSITIONS AND METHODS FOR PREVENTING OR REDUCING POSTOPERATIVE ILEUS AND GASTRIC STASIS - Disclosed are compositions and methods for preventing or reducing postoperative ileus and gastric stasis. Such compositions comprise a combination of an oxidized regenerated cellulose component and a non-steroidal anti-inflammatory drug (NSAID) which functions as an inhibitor of cyclooxygenase enzyme (Cox) activity. Such methods comprise administering an effective amount of the composition directly to the serosal surfaces of the gastrointestinal and other visceral organs. | 05-21-2009 |
20090142388 | Patch preparation - The present invention aims at provision of a patch preparation having a small area and permitting adhesion for a long time. | 06-04-2009 |
20090142389 | HYDROGEL SHEET AND PRODUCTION METHOD THEREOF - Provided is a hydrogel sheet being excellent in strength and flexibility and having high water content in spite of comprising a smaller amount of polymer material; and a method for producing a hydrogel sheet which is convenient and has high productivity. More specifically, provided is a hydrogel sheet comprising (methyl vinyl ether/maleic acid) crosspolymer, low-substituted cellulose ether and water wherein the low-substituted cellulose ether has a molar substitution degree of | 06-04-2009 |
20090155339 | Biocompatible Antimicrobial Filament Material - The invention provides a biocompatible filament material having an antimicrobial finish, in particular in the form of a surficial layer, the finish comprising polyhexamethylenebiguanide (PHMB) as a nonspecifically antimicrobially active component, and also a process for producing the filament material, comprising the steps of:
| 06-18-2009 |
20090162420 | Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids - The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of producing the transdermal therapeutic system. | 06-25-2009 |
20090175926 | TOPICAL BURN TREATMENT - In some embodiments, a method of reducing the possibility of infection in a burn may include one or more of the following steps: (a) identifying a burn wound, (b) applying topically a molecular sieve agent to the burn wound, and (c) allowing the burn wound to scab over due to absorption of moisture. | 07-09-2009 |
20090196908 | EDIBLE FILM-STRIPS WITH MODIFIED RELEASE ACTIVE INGREDIENTS - The present invention is directed to an edible film that contains a modified release active ingredient. The active ingredient may be present in the edible film a variety of forms, including a modified release matrix, in a modified release particulate form, in microgel liquid filled beads or in a bilayer film. The present invention also includes edible films which comprise additional immediate release active ingredients. | 08-06-2009 |
20090202614 | METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS - The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications. | 08-13-2009 |
20090214621 | Electrostatic Patch For Allergen Screening And Applicator For Same - A dermal patch comprises a support having electrostatic properties, which is covered with or can be covered with a substance that is intended to be applied to the skin. The surface of the support that is in contact with the substance is provided with microreliefs. | 08-27-2009 |
20090214622 | Nanoporous Membrane and Method of Preparation Thereof - A nanoporous membrane structure characterised in that it has a hexagonal array of tubes with a substantially uniform inter-pore distance between the tubes wherein the distance is within the range from 10-500 nm and wherein the tubes may have a depth of up to 500 μm. | 08-27-2009 |
20090220577 | Moulded body for medically treating wounds - The invention relates to an absorbable and porous shaped article for the medical treatment of wounds, in particular large, deep wounds with heavy discharge, where the shaped article is in the form of a foam structure which includes a co- and/or terpolymer based on the monomers lactide, triethylene carbonate, ε-caprolactone and/or dioxan-2-one. | 09-03-2009 |
20090232873 | Personal Care Composition in the Form of an Article - Personal care compositions, especially those personal care compositions in the form of an article that is a porous, dissolvable solid structure. | 09-17-2009 |
20090232874 | FIBROUS MEMBRANE FOR BIOMEDICAL APPLICATION BASED ON POLY(ESTER-AMIDE)S - Electrospun biodegradable poly(ester-amide) fabric is especially suitable as a scaffold for tissue engineering and to incorporate drug for burn or wound healing treatment to accelerate healing, or to prevent tissue adhesion after surgery. | 09-17-2009 |
20090246258 | Antimicrobial and odor adsorbing textile - The antimicrobial and odor adsorbing fabric substrate has a surface and at least a portion of the surface is coated with a finish. The finish contains a compound selected from the group consisting of silver particle-containing compounds, silver ion-containing compounds, silver ion-generating compounds, and any combinations thereof, a hyperbranched polyethyleneimine derivative, potassium citrate, inorganic chloride, a polyurethane binder, and a cross-linking agent. The silver-ion containing compound is selected from the group consisting of silver zirconium phosphate, silver zeolite, silver glass, and any mixtures thereof or a conductive silver containing nanoparticle. The hyperbranched polyethyleneimine derivative is of the formula: | 10-01-2009 |
20090246259 | BIOCOMPATIBLE MATERIAL HAVING BIOCOMPATIBLE NON-WOVEN NANO- OR MICRO-FIBER FABRIC PRODUCED BY ELECTROSPINNING METHOD, AND METHOD FOR PRODUCTION OF THE MATERIAL - The present invention provides a biocompatible material, such as a guided tissue regeneration membrane (GTR membrane), a guided bone regeneration membrane (GBR membrane), a sheet material, a patch material, or a compensation material, which has a porous structure to allow transportation of the various factors to induce or facilitate the regeneration. The present invention also provides a manufacturing method for the biocompatible material. | 10-01-2009 |
20090258056 | SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE - A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism. | 10-15-2009 |
20090263467 | COMBINATION DRUG THERAPY USING ORALLY DISSOLVING FILM OR ORALLY DISINTEGRATING TABLET DOSAGE FORMS TO TREAT DRY MOUTH AILMENTS - A combination drug therapy can be administered to patients to treat xerostomia or dry mouth or Sjogren's syndrome in the form of orally dissolving film or orally disintegrating tablets. Some of the drugs could be synthetic origin and some drugs are obtained from natural sources. | 10-22-2009 |
20090263468 | METHODS AND COMPOSITIONS FOR WOUND HEALING - The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polymers to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound. | 10-22-2009 |
20090280160 | PHENYLEPHRINE PHARMACEUTICAL FORMULATIONS AND COMPOSITIONS FOR TRANSMUCOSAL ABSORPTION - Pharmaceutical compositions comprising phenylephrine or a pharmaceutically acceptable salt thereof and methods for administering the pharmaceutical compositions wherein the composition is formulated for systemic absorption of phenylephrine that avoids first pass metabolism. The compositions of the invention are formulated to be applied to oral mucosa of an animal to allow for enhanced systemic delivery of therapeutically active form of phenylephrine. | 11-12-2009 |
20090285875 | Infused Sponge Delivery System - A method for delivering active ingredients to a wet substrate from a flexible, three-dimensional, water-absorbent substrate material comprised of a web of substantially water-insoluble fibers into which is infused a solid anhydrous composition having a melting point of from about 45° C. to about 55° C. said anhydrous composition comprising (i) at least one surfactant selected from the group consisting of cationic quaternary surfactants, anionic surfactants or nonionic surfactants or one multi-lamellar liquid crystal emulsifier system, (ii) at least one fatty alcohol, (iii) at least one emollient selected from the group consisting of cosmetically-acceptable oils, esters and liquid triglycerides, (iv) at least one active ingredient and (v) optionally, a solid cleansing agent having a melting point from about 50° C. to about 70° C. Preferred active ingredients are skincare and haircare actives, including emollients, humectants, conditioning agents, sunscreens and sunblocks, and artificial tanning agents. | 11-19-2009 |
20090285876 | Natural butters reconstituted by transesterification with glycerin and its use in cosmetics applications - The invention provides a composition comprising reaction products from a reaction of a natural butter or natural oil such as shea butter with glycerin in the presence of a basic catalyst and wherein the reaction products retain the unsaponifiable portion of said natural butter or natural oil. The resulting reaction products are self-emulsifiable and are particularly useful in personal care, cosmetic, pharmaceutical, paper and textile applications. | 11-19-2009 |
20090291122 | Wound Care Treatment Product - The invention relates to a wound care treatment product on the basis of honey, wherein the wound care treatment product comprises raw, non-heated honey and an ozonated oil. | 11-26-2009 |
20090297586 | Tissue Products Having A Cooling Sensation When Contacted With Skin - Wiping products, such as facial tissues, contain a temperature change composition that can provide a cooling sensation when contacted with the skin of a user. The temperature change composition, for instance, can contain one or more phase change agents that undergo a phase change at slightly elevated temperatures. The phase change agents, in one embodiment, can have a relatively high heat of fusion. When undergoing a phase change, the phase change agents absorb heat and thereby provide a cooling feeling to the skin of a user. In one embodiment, the phase change agent comprises a straight chain hydrocarbon. Hydrocarbons useful as phase change agents include an octadecane, a nonadecane, a heptonoate, or mixtures thereof. | 12-03-2009 |
20090304778 | Diagnostics and Methods for Removal and Detection of Interferents - Described herein are substrates, methods, articles, and kits that are useful for removing interferents from samples for diagnostic purposes. The interferents are removed with phosphocellulose and cation exchange materials. These materials could also be used in vitro to improve the performance of a diagnostic assay or in vivo to remove the interferents. | 12-10-2009 |
20090311307 | Hydractive Recipe - The invention relates to a method for assembling an adhesive device comprising a first matrix-forming material with holes and a second material, the method comprising:
| 12-17-2009 |
20090311308 | SKINCARE COMPOSITIONS COMPRISING SALICYCLIC ACID - There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises salicylic acid or a salt thereof and hydrolysed milk protein. The composition is useful in the treatment of acne. | 12-17-2009 |
20090317450 | PHARMACOKINETICS OF IONTOPHORETIC SUMATRIPTAN ADMINISTRATION - Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described. | 12-24-2009 |
20090324693 | Delivery Product for Topical Compositions - A delivery product is used to deliver a skin composition to the skin of a user. The delivery product includes a thermo-responsive polymer film. The polymer film is solid at room temperature but, once contacted with the skin, increases in temperature and degrades. A skin composition is associated with the polymer film. The skin composition can be applied to a surface of the film or can be incorporated into the film. The skin composition is released by the polymer film for treating the skin of the user. | 12-31-2009 |
20090324694 | GASTRORETENTIVE DRUG DELIVERY SYSTEM COMPRISING AN EXTRUDED HYDRATABLE POLYMER - According to the present invention there is provided a pharmaceutical product for retention in the stomach. The product is produced by extrusion. The use of extrusion enables the product to take many useful forms. The product may comprise a sheet of hydratable polymer, the hydrated sheet being of a size which will not pass out of the stomach, for example a shaped sheet or a roll. The product may also comprise a scaled hollow tubular extrudate, for example a tube scaled at both ends. The product may comprise a filled capsule. | 12-31-2009 |
20100003311 | Antimicrobial Composition - Use of a composition comprising hyaluronic acid or a pharmaceutically acceptable salt thereof, in the manufacture of a topical medicament for antimicrobial treatment of the skin or mucosa. | 01-07-2010 |
20100008972 | Film for active ingredients dermal and transdermal administration - Single-layer film for active ingredients dermal and transdermal administration containing at least an active ingredient, a film-forming agent, and a hydrophilic adhesive polymer. | 01-14-2010 |
20100008973 | Compositions And Methods For Wound Healing - The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked α-gal epitopes for induction of recruitment of macrophages localized within or surrounding damaged tissue. The recruited macrophages and stem cells promote the repair and regeneration of the treated injured tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects. In some embodiments, the present invention provides treatments for injured tissues such as brain, peripheral nerve, muscle, cartilage, bone, gastrointestinal tract and dysfunctional endocrine tissues. | 01-14-2010 |
20100015207 | Methods for Treating Oral Cavity Infections with Chlorine Dioxide - Methods, devices, compositions, and systems for the alleviation of oral tissue infections by administration of chlorine dioxide are provided. | 01-21-2010 |
20100021526 | PH MODULATED FILMS FOR DELIVERY OF ACTIVES - The invention relates to pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film. | 01-28-2010 |
20100028406 | TOPICAL DRUG DELIVERY BY IONTOPHORESIS - The invention generally concerns methods of topical drag delivery. Delivery according to the invention may be via electrotransport of compounds through the skin, for example by iontophoresis. In certain embodiments improved methods for the delivery of compounds, such as antimicrobial agents are described. | 02-04-2010 |
20100028407 | LAYERED BIO-ADHESIVE COMPOSITIONS AND USES THEREOF - The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided. | 02-04-2010 |
20100028408 | Method for sterilizing unheated raw honey, a honey-based wound care preparation, a wound care treatment product, and a biscuit based on honey - The invention relates to a method for sterilizing raw, unheated honey, wherein the raw, unheated honey is sterilized by ozonizing it by using an ozone generator. The invention also relates to a honey-based wound care preparation, wherein said preparation comprises raw, unheated ozonized honey that has been ozonized by a method according to the invention. The invention also relates to a wound care treatment product comprising a honey-based preparation, wherein the said wound care treatment product comprises a preparation according to the invention. Finally, the invention relates to a biscuit based on honey and food fibres and/or by-products of food fibres, wherein the biscuit is prepared from ozonized food fibres and/or by-products of food fibres and raw, unheated ozonized honey that has been ozonized by a method according to the invention. | 02-04-2010 |
20100028409 | Barrier Membranes For Guided Bone Regeneration - A barrier membrane for guided bone regeneration and a method of manufacturing the same are provided. The barrier membrane for guided bone regeneration that is made of silver, gold, or gold alloy includes a substrate having texture including protrusions with a predetermined shape, a polymer layer formed by coating an upper surface of the substrate with polymer solution, and a bio-ceramic layer formed by coating a lower surface of the substrate. It is possible for the barrier membrane for guided bone regeneration to secure biocompatibility, exclusion and sealing of cells, space maintenance, connectivity with tissues, and easiness of using the barrier membrane which are required for guided bone/tissue regeneration (GBR/GTR). | 02-04-2010 |
20100028410 | IMMUNOGENIC COMPOSITIONS AND METHODS OF USE - Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism. | 02-04-2010 |
20100040672 | DELIVERY OF THERAPEUTICS - The present invention provides materials and devices for the controlled release of therapeutics, and methods for uses thereof. | 02-18-2010 |
20100040673 | HYGIENE TISSUE COMPRISING A MICROBE-INHIBITING COMPOSITION - A hygiene tissue ( | 02-18-2010 |
20100040674 | CONTROLLED DELIVERY OF BIOACTIVE AGENTS FROM DECOMPOSABLE FILMS - A decomposable thin film includes a plurality of multilayer units including a first layer having a first charge and a second layer having a second charge, wherein at least a portion of the multilayers includes a polymeric cyclodextrin associated with a bioactive agent, wherein decomposition of the thin film is characterized by sequential removal of at least a portion of the layers having the first charge and degradation of layers having the second charge and by release of the bioactive agent from a corresponding layers; wherein the decomposable thin film including at least one degradable polyelectrolyte layer that is hydrolyzable. | 02-18-2010 |
20100047321 | SILVER ANTIMICROBIAL COMPOSITION AND USE - Aqueous silver-containing composition is designed for use as an antimicrobial agent on fibers and fabrics. This composition includes silver halide particles, gelatin, and an additive that includes an N-heterocyclic acid having a pKa of from about 4 to about 9. The additive improves the redispersibility and shelf-life of the composition. | 02-25-2010 |
20100047322 | Combination antihypertensive wafer - Sheet-like dosage forms that quickly dissolve or disintegrate in an aqueous environment, for the application of active agent combinations for the treatment of hypertension. The dosage forms contain at least two active agents that are suitable for the treatment of hypertension. The antihypertensive agents are selected from the group that encompasses beta receptor blockers, alpha receptor blockers, calcium antagonists, ACE inhibitors, AT | 02-25-2010 |
20100047323 | CHITOSAN SOLUTION AND MEDICAL PREPARATION WITH CHITOSAN COATING FORMED FROM THE SOLUTION - A chitosan coating solution safe for oral administration, a water resistant chitosan coating film with reduced content of residual organic acid, and a coated medical preparation having the coating film are described. The preparation method includes incorporating a glycerin fatty acid ester into an aqueous chitosan solution prepared through dissolution with a volatile organic acid. The chitosan coating film is obtained by drying and solidifying the solution through film coating. The organic acid used in the dissolution remains in the coating film only minutely and the film is water resistant. When the chitosan coating solution (containing a glycerin fatty acid ester, and prepared through dissolution with a volatile organic acid) is coated, a film is formed therewith, and the organic acid volatilizes simultaneously, producing a chitosan water resistant coating film. Forming a known enteric coating film in combination with the outer coating film allows application to large-intestine drug delivery. | 02-25-2010 |
20100055153 | Multipurpose hydrogel compositions and products - Disclosed are sterile hydrogel compositions comprising polyvinyl alcohol (“PVA”), polyvinyl pyrrolidone (“PVP”), and a polysaccharide, wherein the combined amount of PVA and PVP present in the hydrogel compositions is from about 2% to about 12% weight by volume, based on the total volume of the composition, and wherein the hydrogel compositions has a gel fraction greater than or equal to 97%. Sterile hydrogel products including such sterile hydrogel compositions, and methods of making such sterile hydrogel compositions and sterile hydrogel products. | 03-04-2010 |
20100055154 | COAXIAL ELECTROSPUN FIBERS AND STRUCTURES AND METHODS OF FORMING THE SAME - Nanofibers and microfibers having a core and a polymer shell surrounding the core are provided. The shell includes a plurality of channels that extend from an outer shell surface to the core, and one or more agents, such as pharmacological materials, proteins, viruses, plasmid DNA, bacterial cells, drug-loaded nanoparticles, are encapsulated within the core. The one or more agents discharge from the core through the channels at a controlled rate. The channels are formed by porogen material within the polymer shell. | 03-04-2010 |
20100055155 | SOLID DEODORIZER FOR OSTOMY POUCHES - A solid deodorizer ( | 03-04-2010 |
20100062041 | SKIN SUNSTITUTES, PREPARATION METHODS AND USES THEREOF - Provided herein are skin substitutes suitable for use in a living subject for purpose of repairing damaged tissues, methods of producing the skin substitutes and their uses. A biocomposite membrane comprising poly(ε-caprolactone) (PCL) and at least one material selected from collagen and gelatin is provided. In one embodiment, the biocomposite is a 2-component membrane of PCL and gelatin. In another embodiment, the biocomposite is a 3-component membrane of PCL, collagen and gelatin. The bio-composite membrane may be used directly in vivo as a wound dressing, or as a support for cell growth on each side of the membrane to produce an in vitro cultivated artificial skin for future in vivo and/or in vitro applications. | 03-11-2010 |
20100062042 | Methods, Systems and Devices for Administration of Chlorine Dioxide - Devices, compositions, systems and methods for the non-cytotoxic delivery of chlorine dioxide to a tissue. | 03-11-2010 |
20100062043 | Methods, Systems and Devices for Administration of Chlorine Dioxide - Devices, compositions, systems and methods for the non-cytotoxic delivery of chlorine dioxide to a tissue. | 03-11-2010 |
20100062044 | Method and a product to reduce and treat problems associated with tinea pedis - A ring-shaped toe-patch is provided for treatment and prevention of tinea pedis, commonly known as athlete's foot. The toe-patches are made of rubber-foam, attached to a hydrophobic material for elimination of fungus like | 03-11-2010 |
20100068245 | PREPARATION AND STORAGE OF STABLE, BIOLOGICALLY ACTIVE MATERIALS - A method for the preparation of biologically active materials is presented. The invention involves taking a base material such as allografts, xenografts, polymers, metals, and ceramics and combining it with a biologically active agent, such as proteins, cytokines, growth factors, and enzymes after which it is irradiated with ionizing radiation to sterilize and stabilize the material. The resulting biologically active material may then be stored at ambient temperature while maintaining its biological activity and the structural integrity of the base material. The invention is particularly useful for eliciting desired biological responses in human and animal medicine, and in certain industrial applications. | 03-18-2010 |
20100068246 | Process for Providing a Quantity of a Particulate Material, Product and Apparatus - A process for providing a predetermined quantity of a particulate material in which the particulate material is deposited on a defined area of a sticky surface of a substrate. The process is suitable for deposition of particulate drug material on a substrate such as a strip form substrate which can then be compacted to provide a delivery device for delivering the predetermined quantity of the particulate material. Such a delivery device, and an apparatus to perform the process, comprise further aspects of the invention. | 03-18-2010 |
20100068247 | Method And System For Providing Targeted And Individualized Delivery Of Cosmetic Actives - A system and method are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. The captured image data is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolate, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user. | 03-18-2010 |
20100074943 | MEDICINAL COMPOSITION FOR TRANSDERMAL ABSORPTION, MEDICINAL COMPOSITION STORING UNIT AND TRANSDERMAL ABSORPTION PREPARATION USING THE SAME - An object of the invention is to provide a transdermal absorption preparation capable of sustaining the blood morphine concentration at an effective level over at least 48 hours, etc. This transdermal absorption preparation comprises a medicinal composition for transdermal absorption in which an active ingredient selected from morphine and salts thereof is blended in such an amount as corresponding to the saturation solubility or more in an active ingredient-holding vehicle having fluidity at a temperature around the human skin surface temperature and at least a portion of the active ingredient is held in a crystalline form, characterized in that, in the case where a preparation obtained from the above-described medicinal composition for transdermal absorption is applied to the uninjured skin of the back of a white rabbit having been shaven with electrical clippers for 72 hours, the available amount of the active ingredient per single dose of the preparation is from 10 mg to 400 mg in terms of morphine base, and the plasma concentrations of the active ingredient 24 hours and 48 hours after the application of the preparation under the above-described conditions are each at least 40 ng/mL in terms of morphine base, and so on. | 03-25-2010 |
20100092544 | Adhesive composition for patch and use thereof - The present invention provides an adhesive composition for patch, containing a rubber elastomer and a tackifier having a weight average molecular weight of 1200-2500, a patch having a support and an adhesive layer containing the composition, which is provided on at least one surface of the support, and a patch preparation having an adhesive layer containing a percutaneously absorbable drug (excluding bisoprolol). | 04-15-2010 |
20100092545 | POLYETHYLENE-OXIDE BASED FILMS AND DRUG DELIVERY SYSTEMS MADE THEREFROM - The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. | 04-15-2010 |
20100112036 | Cyanoacrylate-based liquid microbial sealant drape - The invention relates to methods of using compositions for forming microbial sealant drapes. In particular, the invention relates to the use of compositions of combinations of cyanoacrylates for the in situ formation of drapes that can be used in surgery to protect patients from surgical site infections. | 05-06-2010 |
20100119583 | SOLID DOSAGE FORM WITH A FILM CONTAINING AN ACTIVE SUBSTANCE, AS WELL AS ITS METHOD OF PRODUCTION - The present invention relates to a solid dosage form with at least one film ( | 05-13-2010 |
20100129426 | PROTECTIVE AGENT AGAINST DAMAGE OF BIOLOGICAL TISSUE CAUSED BY NEAR-INFRARED RAY AND PRODUCT COMPRISING THE SAME - The present invention is to provide a protective agent against damage of biological tissue caused by near-infrared rays which is capable of blocking the near-infrared rays from reaching not only skin but also deeper tissue than the skin tissue, preventing damage of such tissue caused by the near-infrared rays and preventing pathogenesis and development of various disease and acceleration of aging both of which are caused by the near-infrared rays, and a product using the protective agent. The protective agent against damage of biological tissue caused by near-infrared rays comprises a near-infrared ray penetration blocker that absorbs, reflects or scatters the near-infrared rays to prevent the damage of skin and deeper tissue than the skin in a living body caused by exposure with the near-infrared rays. | 05-27-2010 |
20100136091 | METHODS, SYSTEMS, AND COMPOSITIONS FOR EXTRACELLULAR MATRIX PRODUCTION - Compositions, methods, and kits for repair and production of extracellular matrix are provided. In the broad aspect, the composition comprises a ligand of α5β1 integrin attached to a surface of a nanoparticle composed of a protein, with a proviso that the protein is not fibronectin. | 06-03-2010 |
20100143445 | Dermatological/cosmetic skin depigmenting compositions - Depigmenting compositions having improved effectiveness in the dermatological or cosmetic treatment of pigmentation contain, in a physiologically acceptable medium, at least one compound selected from among rucinol and salts thereof, and at least one retinoid; such compositions are also useful in the prevention and/or dermatological treatment of skin hyperpigmentation, and also for the cosmetic treatment of photoinduced or chronological aging of the skin or of the skin appendages. | 06-10-2010 |
20100143446 | Novel skin moisturizing compositions - Novel skin moisturizing compositions are applied onto dry skin, particularly mild to moderately dry skin, are non-irritating and contain at least one natural moisturizing factor, | 06-10-2010 |
20100150987 | Method for Manufacturing Edible Film - The present invention provides a process for making an edible film having a substantially uniform distribution of components, which includes the steps of combining a water-based film polymer solution and a slurry-type mixture comprising a water-active component and a solvent; mixing the polymer solution and slurry-type mixture for about 10 minutes or less; dispensing the mixed solution and slurry-type mixture to form a film; and drying the film to evaporate the water and solvent. Films made by the process are also provided. | 06-17-2010 |
20100150988 | FILM-LIKE ORALLY ADMINISTERED MEDICATION AND MANUFACTURING METHOD THEREFOR - Film-like orally administered medications are provided which are less likely to be attached to the oral mucous membrane upon intake and can be easily detached therefrom even if attached thereto. A film-like orally administered medication ( | 06-17-2010 |
20100158985 | Porous structures of microbial-derived cellulose for in vivo implantation - This invention relates to polysaccharide materials and more particularly to microbial-derived cellulose having the porosity and containing pores of the desired size making it suitable for cellular infiltration during implantation and other desirable properties for medical and surgical applications. The invention also relates to the use of porous microbial-derived cellulose as tissue engineering matrices, human tissue substitutes, and reinforcing scaffolds for regenerating injured tissues and augmenting surgical procedures. The invention outlines various methods during and after fermentation to create porous microbial cellulose capable of allowing cell infiltration while preserving the physical properties of the microbial-cellulose. | 06-24-2010 |
20100158986 | Personal Care Composition Providing Quietness and Softness Enhancement, Methods of Preparing and Articles Using the Same - The present disclosure generally relates to personal care compositions and personal care products. More particularly, the disclosure relates to personal care compositions and personal care products that impart perceivable aesthetic benefits of increased softness, quietness and drapability to the skin or hair of a user. To achieve the perceivable aesthetic benefit, a protonated skin aesthetic agent selected from fatty acids, fatty alcohols, fatty acid derivatives, fatty alcohol derivatives, and/or combinations thereof, may be incorporated into the personal care compositions and personal care products. To produce the liquid composition, a deprotonated skin aesthetic agent is first provided. The deprotonated skin aesthetic agent is added to an aqueous liquid solution. The aqueous liquid solution is then acidified with an acidifying agent to protonate the deprotonated skin aesthetic agent. Finally, the aqueous liquid solution is incorporated onto a wipe substrate. | 06-24-2010 |
20100158987 | Adhesive Label With Bittering Agent and Fluidifying Agents for Natural Airway Secretions - Label for the outerwear for thinning of airway secretions, containing a bittering agent to reduce the likelihood of accidental ingestion. | 06-24-2010 |
20100158988 | CEREAL BETA GLUCAN COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF - Cereal β(1-3) β(1-4) glucan is used as a film or coating agent to produce clear, edible, biodegradable, delivery, lubricating, and protecting agents. Cereal β(1-3) β(1-4) glucans are distinctive polymers of glucose differentiated from other polymers by not only their source but also their physicochemical properties. The β(1-3) β(1-4) forms a matrix to sequester other materials, such as pharmaceutical, medical and therapeutic agents, flavours, fragrances. The technology has applications to essential oils and non-aqueous materials that are rendered deliverable by the β(1-3) β(1-4) glucan. The β(1-3) β(1-4) glucan films described may be consumed whereby they dissolve in the mouth in a controlled manner and may be used for the delivery of pharmaceutical, medical or confectionery products. | 06-24-2010 |
20100166832 | Silver coated nylon fibers and associated methods of manufacture and use - Silver coated nylon fibers are disclosed that can be used to make fabrics that are silver coated on one side of the fabric. Silver coated nylon fabrics provide an antimicrobial surface which remains on the surface and retains its antimicrobial characteristic until destroyed. The methods of adherence of the silver to the nylon fabric may be performed in a number of ways. The creation of a single fabric with one side silver coated and the other side being dyed or left natural is encompassed within this invention. In addition there can be more than two yarns creating the fabric such as the use of spandex to provide a more elastic garment. | 07-01-2010 |
20100166833 | Compositions, articles and methods for preventing or reducing tobacco-associated damage - Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed. | 07-01-2010 |
20100166834 | PREPARATIONS BASED ON FIBRINOGEN AND SULFATED POLYSACCHARIDES - The present invention provides a preparation comprising fibrinogen and a sulfated polysaccharide as a one component composition or as a kit of parts comprising fibrinogen and sulfated polysaccharide as separated components. | 07-01-2010 |
20100172957 | EFLUCIMIBE MEDICAMENTS FOR PREVENTING/TREATING A DISEASE DUE TO SEBACEOUS GLAND DYSFUNCTION IN HUMANS OR ANIMALS - Administration of at least one compound selected from (S)-2-dodecylsulfanyl-N-(4-hydroxy-2,3,5-trimethylphenyl)-2-phenylacetanilide (eflucimibe) of formula (I): | 07-08-2010 |
20100178318 | Composite Structure Including A Low Vinyl Acetate Layer - A composite structure suitable for making transdermal delivery devices includes in sequence: (a) a liner film layer; (b) a containment layer having from zero to 15 wt. % content of vinyl acetate repeating units, the layer including either a thermal bonding copolyester resin or a combination of an ethylene-vinyl acetate component and a nonpolar polymer; and (c) a polyester film layer less than 20 μm in thickness. A drug layer lies either between the liner film layer and the containment layer or within a concave depression in the containment layer. A composition including an ethylene-vinyl acetate component and an ABA block copolymer, wherein the A segments of the block copolymer are styrenic segments, is also provided. The composition includes between 1 and 15 wt. % of vinyl acetate repeating units, based on the total weight of composition exclusive of any solvents. | 07-15-2010 |
20100178319 | Topical Dermal Delivery Device For Nitric Oxide Delivery - A topical dermal delivery device, such as a patch, for topical delivery of nitric oxide (NO) to treatment sites of mammals is disclosed. In an embodiment the patch has three layers; a backing with an activation window, a absorbent core as a reservoir and an NO permeable membrane with an adhesive layer towards the skin. The NO donor is applied into the device as a solution prior to application through the activation window. The window is closed after activation and the lid and backing is non-permeable for NO in order to increase the partial pressure of NO and thus the concentration of dissolved NO. The patch is fixated on the area to be treated with an adhesive layer that also assures sufficient contact throughout the treatment. The generated NO moves within the patch and can escape through the NO permeable membrane towards the area to be treated. Depending on therapy needed, the patch release curve differs and is chosen accordingly. | 07-15-2010 |
20100178320 | NEW MEDICAL PRODUCTS - The present invention provides a wound care product comprising a wound care material and a polypeptide having wound care properties. In one embodiment, the wound care material comprises or consists of alginates, amorphous hydrogels, sheet hydrogels, hydrofibres, foams and mixtures thereof. In a further embodiment, the polypeptide having wound care properties is a cathelicidin, such as LL-37. The invention further provides methods of treatment of wounds using the products of the invention. | 07-15-2010 |
20100178321 | PRESSURE-SENSITIVE ADHESIVE COMPOSITION APPLICABLE TO NAIL AND ADHESIVE AGENT FOR NAIL - The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition. | 07-15-2010 |
20100189769 | Polypeptide Films and Methods - Disclosed herein are polypeptide multilayer films wherein a therapeutic agent is covalently linked to a first layer polypeptide. An advantage of such attachment is that the linked therapeutic agent can be controllably released from the multilayer film into the environment of the film upon the addition of a suitable stimulus. An advantage of the disclosed films and methods is enablement of environmentally-stimulated release under specific conditions. | 07-29-2010 |
20100196444 | DEVICES WITH CELLS CULTURED ON FLEXIBLE SUPPORTS - Methods and compositions provide suitable support material for culturing cells with a desirable metabolic activity. For example, keratinocytes directly grown on flexible supports show metabolic activity. Wound healing methods and compositions using the cells grown on flexible supports, wherein the cells exhibit increased metabolic activity are disclosed. | 08-05-2010 |
20100196445 | SYSTEMS AND METHODS FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS - The invention provides methods and devices for the delivery of therapeutic or biologically active agents to tissue, for example by facilitating the transport of said agents through the skin of a human or animal. Therapeutic agents include various botulinum neurotoxin (BoNT) and other biologically active agents, which can be delivered across the skin and into the dermis using multiple strategies including microneedle drug delivery, transport moieties, or penetration enhancers such as extracellular matrix-digestive enzymes. | 08-05-2010 |
20100196446 | Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface - The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc. | 08-05-2010 |
20100196447 | SILK BIOMATERIALS AND METHODS OF USE THEREOF - The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo. | 08-05-2010 |
20100203107 | Methods of Administering a Dermatological Agent to a Subject - Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications. | 08-12-2010 |
20100209479 | Compositions And Methods For Treating Cancer - The present invention relates to compositions and methods for treating cancer and, in particular, to composition and methods comprising nanostructures. In one embodiment, the present invention provides a composition comprising a mixture, the mixture comprising at least one nanoparticle and at least one chemotherapeutic. | 08-19-2010 |
20100209480 | GALENICAL FORMULATIONS OF ORGANIC COMPOUNDS - The present invention relates to a pharmaceutical oral fixed dose combination comprising
| 08-19-2010 |
20100215721 | POULTICE AND PROCESS FOR PRODUCING THE POULTICE - This invention provides a poultice, which can prevent both runover of a medicated layer and separation from a subject for which the poultice is applied, and a process for producing the poultice. A poultice ( | 08-26-2010 |
20100221305 | Formulations for coated microprojections containing non-volatile counterions - The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation. | 09-02-2010 |
20100221306 | ADHESIVE GEL SHEET FOR LIVING ORGANISMS AND SHEET FORM COSMETICS COMPRISING THE SAME - To provide an adhesive gel sheet for living organisms which may allow efficient permeation of the skin by carotenoid, and also provide a sheet-form cosmetic using the same, It is provided an adhesive gel sheet for living organisms which includes a hydrogel having a carotenoid-containing O/W emulsion, gelatin or a derivative thereof and a hydrophilic polymer, and further comprises a polyvalent inorganic salt, wherein the content of the polyvalent inorganic salt is 0.1% or less by mass of the entire mass of the hydrogel. It is preferable that the hydrophilic polymer be a polysaccharide that forms a thermoreversible gel. | 09-02-2010 |
20100221307 | ANTIVIRAL AGENTS, ANTIVIRAL FIBERS AND ANTIVIRAL FIBER STRUCTURES - Provided are antiviral agents that are effective in inactivating viruses, and fiber products and fiber structures carrying these antiviral agents. The antiviral agent effectives against influenza and comprises a metal phthalocyanine derivative represented by formula I. Fiber carries these antiviral agents. | 09-02-2010 |
20100221308 | ANTIMICROBIAL COMPOSITIONS AND USES THEREOF - The present invention includes compositions for preventing growth and proliferation of biofilm embedded microorganisms comprising: (a) a cationic polypeptide and (b) a bis-gaunide or a salt thereof. The invention further provides methods for preparing objects with such compositions, and objects and consumables (such as household cleaners) comprising such compositions. | 09-02-2010 |
20100221309 | FILM COMPOSITIONS FOR DELIVERY OF ACTIVES - The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain at least one active agent, which may be administered to a user topically, transmucosally, vaginally, ocularly, aurally, nasally, transdermally or orally. | 09-02-2010 |
20100221310 | MEDICAL PRODUCTS INCLUDING MODIFIED EXTRACELLULAR MATRIX MATERIALS - Described, in certain aspects, are medical products comprised of uniquely prepared remodelable extracellular matrix (ECM) materials retaining at least a portion of their native bioactivity. Also described are methods for forming and using such products. In one embodiment, an inventive product comprises a layer of remodelable ECM material modified through contact with periodic acid or a salt thereof. In some forms, such a modified ECM material layer includes non-native Schiff's base crosslinks within and/or between certain components of the ECM material (e.g., between two collagen molecules, two non-collagen molecules, and/or a collagen molecule and a non-collagen molecule). Other inventive products are comprised of various gels, foams, pastes, and formed, coherent, porous bodies at least containing ECM materials that have been modified in accordance with the present invention. | 09-02-2010 |
20100226964 | Highly Compactable and durable direct compression excipients and excipient systems - The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness. | 09-09-2010 |
20100233244 | Smoking Withdrawal Combination Wafer - The present invention relates to a quickly decomposing oral drug preparation, for the application of active ingredient combinations for smoking withdrawal, which contains nicotine, a nicotine salt, a nicotine derivative, or a substance that reacts to nicotine, in combination with another active ingredient, and the use of such a drug preparation for the treatment of smoking withdrawal, and the use of nicotine, and/or nicotine salts or derivatives, for the production of medications for the treatment of smoking withdrawal. The active ingredient that is to be administered, in combination, for this purpose is a centrally active ingredient, preferably an antidepressant for the fighting of psychic dependency in terms of a smoking withdrawal therapy. The administration of the active ingredient combination to the patient should be handled in a simple and reliable way and should exclude side effects to a large extent. | 09-16-2010 |
20100233245 | NANOPARTICLE COMPOSITION AND PROCESS THEREOF - The present invention relates to nanoparticle composition comprising cellulose nanofibers embedded with nanosized material. More particularly the present invention relates to cellulose nanofibers embedded with silver or iron oxide embedded silver. In addition the present invention is also related to the preparation of the cellulose nanofibers embedded with nanosized material. The nanoparticle composition is antibacterial in nature and can be utilized in various antibacterial applications. | 09-16-2010 |
20100233246 | ADHESIVE TISSUE REPAIR PATCH AND COLLAGEN SHEETS - The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples. | 09-16-2010 |
20100239639 | MEDICATED PATCH - A conventional medicated patch containing an anti-inflammatory agent causes a dermatitis or the like on rare occasion by excess irradiation with light. For overcoming the problem, a medicated patch is provided, which comprises an anti-inflammatory agent, BM-DBM as an ultraviolet absorber, and hexyl laurate as an agent for accelerating the migration of the ultraviolet absorber into the skin in an adhesive base material thereof. | 09-23-2010 |
20100239640 | SKIN-DERIVED PRECURSOR CELLS AND USES THEREOF - The invention features methods of inducing hair follicle formation in a mammal by transplantation of skin-derived precursors (SKPs) and keratinocytes into the skin of the mammal. The invention also features compositions and kits including SKPs and keratinocytes. In other aspects, the invention features methods for producing dermal sheets from SKPs, methods for using such sheets and dermal sheets produced by SKPs. | 09-23-2010 |
20100239641 | Warming vapor pad - A warming vapor pad to treat respiratory syncytial virus infections in babies, children and adults includes a fabric impregnated with a topical ointment providing medicated vapors to relieve a user's cough, with the fabric being superimposed on an elastic thermal wrap for application as a single layer on the user's chest. | 09-23-2010 |
20100239642 | COATING COMPOSITIONS - Described are coating compositions for marking substrates comprising a) a solvent, b) a salt of a phosphorus or boron containing acid and an amine or imine, c) a salt of a non-phosphorus and non-boron containing acid and an amine or imine, d) a binder, and e) optionally additional ingredients, their manufacture and use, wherein the above-mentioned salts can also be present in an encapsulated form as a kind of pseudo-pigment. Substrates coated by the above compositions can be marked by laser irradiation. | 09-23-2010 |
20100239643 | ANTI-ITCH SHEET - The present invention provides an anti-itch sheet suitable for curing and relieving itching caused by an insect bite or sunburn based on a novel finding, the anti-itch sheet comprising a sealing layer, and a fixing layer on a skin-contacting side of the sealing layer for facilitating the application of the sealing layer to the skin. | 09-23-2010 |
20100239644 | Method of Preparing Polymeric Adhesive Compositions Utilizing the Mechanism of Ineraction Between the Polymer Components - A method of selecting components for use in water-absorbing pressure-sensitive adhesive compositions is provided. The method involves selecting a film-forming polymer, a ladder-like non-covalent crosslinker that is capable of forming a ladder-like interpolymer complex with the film-forming polymer selected, and selecting a carcass-like non-covalent crosslinker that is capable of forming a carcass-like complex with at least one of the film-forming polymer selected or the ladder-like non-covalent crosslinker selected. The adhesive hydrogels provide high adhesion in a swollen state and bridge the gap between conventional pressure sensitive adhesives and bioadhesives. Methods for preparing and using the resulting compositions are also disclosed. | 09-23-2010 |
20100247608 | PHARMACEUTICAL COMPOSITIONS COMPRISING HGH FOR ORAL DELIVERY - The present invention relates to dosage forms of human growth hormone, the use of an absorption enhancer to allow absorption of human growth hormone into the systemic circulation in a biologically active form, in particular after oral administration, as well as the use of oral dosage forms comprising human growth hormone and an absorption enhancer for the treatment of human growth hormone deficiencies and disorders associated therewith. | 09-30-2010 |
20100247609 | PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions for oral administration, in particular administration as an oral delivery system to be swallowed directly or capable of disintegration in the oral cavity, comprising iron oxy-hydroxide in high loading. | 09-30-2010 |
20100247610 | GASTRIC RETAINED GABAPENTIN DOSAGE FORM - A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form. | 09-30-2010 |
20100247611 | TITANIUM DIOXIDE NANOTUBES FOR PRODUCTION AND DELIVERY OF NITRIC OXIDE AND METHODS FOR PRODUCTION THEREOF - The present disclosure describes compositions operable for releasing nitric oxide under photochemical conditions. The compositions include a titanium dioxide nanomaterial and a nitric oxide-releasing compound deposited on the titanium dioxide nanomaterial that is operable to release nitric oxide under photochemical conditions. Titanium dioxide nanomaterials include, for example, titanium dioxide nanotubes. To facilitate the photochemical release of nitric oxide, some embodiments of the compositions further include a semiconductor that is deposited on the titanium dioxide nanotubes. Both the semiconductor and the nitric oxide-releasing compound may be deposited on the interior surface, exterior surface, or both of the titanium dioxide nanotubes. A polymer may wrap the titanium dioxide nanotubes to protect the nitric oxide-releasing compounds from moisture. Also disclosed herein are methods for producing such compositions and medical devices obtained therefrom. | 09-30-2010 |
20100247612 | EXTRUDABLE AND EXTRUDED COMPOSITIONS FOR DELIVERY OF BIOACTIVE AGENTS, METHOD OF MAKING SAME AND METHOD OF USING SAME - A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. An extruded bioactive product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and a bioactive agent, the sheet being soluble in a user's mouth and resulting in sustained release of bioactive to the user. The sheet can be in a form that may be placed in contact with the mucosa of the user, and have an average dissolution time of 5 to 50 minutes for delivering the bioactive to the user. | 09-30-2010 |
20100255065 | METHOD FOR DIFFERENCIATING MESENCHYMAL STEM CELL AND CULTURING CHONDROCYTES USING ALGINATE COATED FIBRIN/HA COMPOSITE SCAFFOLD - The present invention relates to a method for differentiating mesenchymal stem cells and culturing chondrocytes using a fibrin/HA(hyaluronate) composite whose biocompatibility and durability are enhanced, and a therapeutic composition containing the fibrin/HA composite, and more particularly, to a method for culturing chondrocytes and differentiating mesenchymal stem cells into chondrocytes using an alginate-coated fibrin/HA composite gel and a composition for treating a cartilage disease and a composition for treating a disc disease using a fibrin/HA composite scaffold containing a fibrin degradation inhibitor. According to the present invention, disadvantages of the traditional fibrin/HA composite being reduced in size and easily degraded in a short time period during culture were overcome, so that cells can be cultured in a more stable environment. The treatment composition according to the present invention has superior biocompatibility and biodegradability and thus it can be used for effective treatment for cartilage diseases, and it can regenerate the nuclei pulposi of a new intervertebral disk unlike currently used surgical treatment of degenerative intervertebral disk disease, so that it is expected that fundamental treatment of disc diseases can be achieved. | 10-07-2010 |
20100255066 | ORALLY-ADMINISTERED AGENT - An orally-administered agent comprised of a laminated body having surface layers is provided. The laminated body comprises a medicine-containing layer containing a medicine and having surfaces; and at least one gel-forming layer provided on one of the surfaces of the medicine-containing layer as one of the surface layers of the laminated body. The at least one gel-forming layer includes a gel-forming agent to be swelled and gelatinized when absorbing a water-based liquid. A water absorption speed per 1 g of the gel-forming layer with respect to water of 37° C. is 0.5 g/(g·s) or higher. A gel fraction of the gel-forming layer is 20 mass % or more when the gel-forming layer is dipped into an aqueous solution of 0.9 mass % of sodium chloride having a temperature of 37° C. | 10-07-2010 |
20100255067 | Controlled Release Pharmaceutical Compositions of Pregabalin - A controlled release pharmaceutical composition which comprises therapeutically effective amount of pregabalin or salts thereof as active ingredient, a hydrophobic release controlling agent(s) and optionally other pharmaceutically acceptable excipients thereof. | 10-07-2010 |
20100255068 | HAIR-LIKE SHAPED HYDROGELS FOR SOFT TISSUE AUGMENTATION - Hair-like shaped crosslinked hydrogels and methods for preparing such crosslinked hydrogels and are provided. | 10-07-2010 |
20100255069 | COMPOSITIONS AND METHODS FOR TREATING ANGIOGENESIS-RELATED DISEASES, WOUNDS AND COSMETIC USE OF COMPONENTS OF ANGELICA SINENSIS, AND METHODS OF PREPARATION THEREOF - Compositions and methods for treating angiogenesis-related diseases and for skin care in mammals is disclosed that includes, as an active pharmaceutical agent, an effective amount of purified extract from | 10-07-2010 |
20100260819 | REDUCING POST-OPERATIVE ADHESION FORMATION WITH INTRAPERITONEAL GLUTAMINE - Intraperitoneal administration of glutamine reduces post-operative adhesion formation. | 10-14-2010 |
20100260820 | PLASTER FOR PLANTS WITH AN EXPANDED MATRIX - The invention relates to a plaster for applying systemic active substances to plants, the matrix thereof, that contains the active substance, is expanded and consists of in particular, a hot melt adhesive containing the active substance. Said plaster, based on its flexibility and adhesiveness, is suitable for applying active substances to the trunk or branches of trees. | 10-14-2010 |
20100260821 | Allergen Desensitization Method - The present application relates to a method for desensitization of allergic patients. More specifically it relates to an epicutaneous desensitization method, applicable to any type of allergens and of patients. The method of the invention is essentially non-invasive and does not require the use of adjuvants. Further, it may be easily applied and monitored by the actual patient. | 10-14-2010 |
20100266667 | MUCOSAL BIOADHESIVE SLOW RELEASE CARRIER FOR DELIVERING ACTIVE PRINCIPLES - A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation. | 10-21-2010 |
20100266668 | Manufacturing Dissolvable Dosage Forms - A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube ( | 10-21-2010 |
20100272782 | ACELLULAR TISSUE MATRIX COMPOSITIONS FOR TISSUE REPAIR - The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions. | 10-28-2010 |
20100278902 | STRONTIUM DOPED BIOACTIVE GLASSES - The invention relates to bioactive glasses containing or doped with strontium, to a method for preparing the same and to the use thereof in methods for bone repair or reconstruction. | 11-04-2010 |
20100285099 | VACCINATION BY TRANSCUTANEOUS TARGETING - The present invention relates to a method of vaccination via hair follicles that makes it possible to target vaccine components to the antigen-presenting cells in order to induce a protective and effective immune response against pathogens. | 11-11-2010 |
20100291183 | ENHANCED MOISTURE BARRIER IMMEDIATE RELEASE FILM COATING SYSTEMS AND SUBSTRATES COATED THEREWITH - The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed. | 11-18-2010 |
20100303891 | SUPRAMACROMOLECULAR POLYMER COMPLEXES PROVIDING CONTROLLED NITRIC OXIDE RELEASE FOR HEALING WOUNDS - A bio-adhesive supramacromolecular complex of the general formula: | 12-02-2010 |
20100310631 | FILAMENT BASED ON HYALURONIC ACID IN THE FORM OF FREE ACID AND METHOD FOR OBTAINING IT - The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions. | 12-09-2010 |
20100316693 | Method for preparing an antimicrobial cotton of cellulose matrix having chemically and/or physically bonded silver and antimicrobial cotton prepared therefrom - There is provided a method for preparing a natural cellulose-AgO matrix having antimicrobial activity without leaching silver from the cellulose-AgO matrix. The method comprises: introducing silver ions (Ag | 12-16-2010 |
20100316694 | NOVEL FILTER COMPOSITES FOR DRUG DETOXIFICATION - A filter and a method of forming a suture structure. The filter includes layered structure(s) interior to the filter. Each layered structure includes a carbon structure comprising carbon and a coating on a surface of the carbon structure. Each layered structure may further include a heparin layer that includes heparin and is on the coating. The coating of the filter includes cellulose, PMMA, PEMA, or PHEMA. The carbon structure may include an activated charcoal layer or carbon nanotube(s). The layered structure is configured to remove a contaminant flowing through the filter. The method of forming the suture structure includes forming a film on a suture that has been previously formed on a mammal. The film includes both a coating on the suture and a heparin layer that includes heparin and is on the coating. The coating of the suture structure includes cellulose, PMMA, PEMA, or PHEMA. | 12-16-2010 |
20100322996 | Fluid Absorbent Adhesive Articles - A fluid absorbing pressure sensitive adhesive composition and adhesive articles including the fluid absorbing adhesive that have particular utility in the medical field, and in particular, for use with wound dressings is provided. The adhesive composition has superior fluid handling capacity, moisture vapor transmission and skin adhesion. | 12-23-2010 |
20110002975 | PREOPERATIVE TREATMENT OF POST OPERATIVE PAIN - A method of treating postoperative pain in a patient undergoing a surgery is described. The method is based on preoperative administration of a buprenorphine-containing transdermal dosage form. The dosage form can be administered to the patient, for example, 1-4 days prior to surgery. Alternative embodiments of the invention include subsequent transdermal dosage forms to treat the postoperative pain. | 01-06-2011 |
20110008411 | METHOD OF TREATING PRURITIS - The present invention relates to a method of treating dermatologic pruritis. The skin involved with purities is covered with an organic cloth in order to make it more difficult to scratch. The contact of the organic cloth not only makes it difficult to scratch but adds a soothing feel thus lessening the tendency to need to scratch. | 01-13-2011 |
20110008412 | Oral Formulations for 5-HT-Receptor Agonists, Uses and Methods of Treatment Employing The Same - A pharmaceutically acceptable oral formulation comprising core material which comprises a therapeutically effective amount of a 5-HT-receptor agonist, or a pharmaceutically acceptable salt, solvate or derivative thereof, which core material is provided with a substantially water resistant coating comprising one or more substantially water resistant materials. | 01-13-2011 |
20110038916 | Sanitizers - The present invention provides sanitizer systems for improving personal hygiene and reducing the potential for the spread of disease. The sanitizer systems enable more thorough cleansing by providing mechanically removal of microbial agents and soil from the skin with an absorbent sheet. | 02-17-2011 |
20110038917 | THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING GRAM-NEGATIVE BACTERIAL INFECTIONS - The present invention relates to therapeutic compositions and methods of treatment that contain or employ at least two of: an oligomeric proanthocyanidin; a protease inhibitor; and/or a lactoferrin. The compositions of this invention may be in various forms depending upon the disease or condition to be treated. The compositions and methods of this invention are useful to treat a patient suffering from or susceptible to gram negative bacterial infections, including those associated with cystic fibrosis, ear infections and with wounds. | 02-17-2011 |
20110038918 | Composition For Transdermal Delivery of Fentanyl - A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl. | 02-17-2011 |
20110038919 | TEXTILE MATERIALS WITH ADHESIVE AND METHODS FOR USE THEREOF - Textile materials for management of skin health complications associated with skin folds, as well as adhesives for attaching the materials to the skin of a subject. The adhesive can be supplied separately from the material, for application post-production, or can be applied to the material during production. | 02-17-2011 |
20110052662 | ANTIBACTERIAL MATERIAL AND ANTIBACTERIAL FILM AND ANTIBACTERIAL MEMBER USING THE SAME - In one embodiment, an antibacterial material includes at least one microparticles selected from tungsten oxide microparticles and tungsten oxide complex microparticles. The microparticles, which are undergone a test to evaluate viable cell count by inoculating in a test piece, to which the microparticles are adhered in a range of 0.02 mg/cm | 03-03-2011 |
20110059155 | WATER RESISTANT PATCH PREPARATION - The present invention provides a water resistant patch preparation having a central part and a peripheral part, which preparation is comprised of a support and an adhesive layer comprising a drug, which is formed on one surface of the support, wherein at least a part of a lateral end of the adhesive layer in the peripheral part is located inside a lateral end of the support, and the adhesive layer in the peripheral part has a thickness smaller than that of the adhesive layer in the central part. | 03-10-2011 |
20110064784 | METHOD FOR PRODUCING A THREE-DIMENSIONAL MACROPOROUS FILAMENT CONSTRUCT BASED ON PHASE INVERSION AND CONSTRUCT THEREBY OBTAINED - The present invention relates to a method for producing a three-dimensional macroporous filament construct comprising interconnected microporous filaments showing a suitable surface roughness and microporosity. The method comprises the steps of: a) preparing a suspension comprising particles of a predetermined material, a liquid solvent, one or more binders and optionally one or more dispersants, b) depositing said suspension in the form of filaments in a predetermined three-dimensional pattern, preferably in a non-solvent environment, thereby creating a three-dimensional filament-based porous structure, c) inducing phase inversion, whereby said filaments are transformed from a liquid to a solid state, by exposing said filaments during the deposition of the filaments with a non-solvent vapour and to a liquid non-solvent, d) thermally treating the structure of step d) by calcining and sintering said structure. The invention further provides a three-dimensional macroporous filament construct comprising interconnected microporous filaments showing a specific surface roughness and microporosity. The invention also relates to various uses of the construct, including its use for the manufacture of a biomedical product, such as a synthetic bone implant or bone graft. | 03-17-2011 |
20110064785 | Nanostructure-Enhanced Platelet Binding and Hemostatic Structures - Methods, systems, and apparatuses for nanomaterial-enhanced platelet binding and hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce platelet binding, including platelet binding and the coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. Example embodiments include platelet binding devices, hemostatic bandages, hemostatic plugs, and hemostatic formulations. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers, silicon nanofibers, silicon dioxide nanofibers, and/or glass beads into a highly absorbent, gelling scaffold. The hemostatic materials and structures may be resorbable. | 03-17-2011 |
20110081401 | DERMAL PATCH COMPRISING CHONDRUS CRISPUS EXTRACT - The present invention relates to masks for dermal treatment or “patches”, based on a vegetal matrix, particularly red algae ( | 04-07-2011 |
20110086084 | Active Agent Containing Polymer Network Delivery Composition and Articles Using the Same - Delivery compositions and substrates for imparting a volatile active agent to a surface are disclosed herein. To achieve the delivery of the volatile component, a delivery composition of a polymer network and a volatile component incorporated into the polymer network to stabilize the volatile for extended periods of time. The delivery composition may also be present on a substantially dry substrate to deliver the active agent. The dry substrate may be selected from facial tissue, bath tissue, paper towel, or dinner napkin. The substantially dry substrate may also be reusable. | 04-14-2011 |
20110086085 | Carbohydrate Entrapped Active Agent Delivery Composition and Articles Using the Same - Delivery compositions and substrates for imparting a volatile active agent to a surface are disclosed herein. To achieve the delivery of the volatile component, a delivery composition of a carbohydrate matrix and a volatile component is incorporated into the carbohydrate matrix to stabilize the volatile for extended periods of time. The delivery composition further comprises a self-generating expelling agent to expel the volatile component onto the contaminated surface or skin upon addition of a triggering agent. | 04-14-2011 |
20110104240 | Nitric Oxide Device and Method for Wound Healing, Treatment of Dermatological Disorders and Microbial Infections - The present disclosure provides a device having a casing with a barrier surface and a contact surface and a composition in the casing having a nitric oxide precursor and an isolated enzyme or live cell expressing an endogenous enzyme, for converting the nitric oxide gas precursor to nitric oxide gas or having activity on a substrate that produces a catalyst that causes the conversion of the nitric oxide gas precursor to nitric oxide gas. The present disclosure also provides methods and uses for treating wounds, microbial infections and dermatological disorders and for preserving meat products. | 05-05-2011 |
20110104241 | PERCUTANEOUS ABSORPTION ENHANCER AND TRANSDERMAL PREPARATION USING THE SAME - Provided are a percutaneous absorption enhancer excellent in an enhancing effect on percutaneous absorption of a wide range of drugs and excellent in compatibility with an adhesive base, and a transdermal preparation using the percutaneous absorption enhancer. The percutaneous absorption enhancer includes a sulfosuccinate or a salt thereof and an alkyl glycoside or an alkyl thioglycoside. | 05-05-2011 |
20110104242 | CARTILAGE MATERIAL - Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect. | 05-05-2011 |
20110111011 | SUBLINGUAL APOMORPHINE - The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith. | 05-12-2011 |
20110117174 | ADHESIVE ARTICLE CONTAINING COLORANT AND/OR ACTIVE AGENT - The invention relates to adhesive articles containing at least one colorant and/or at least one active agent as well as to methods of using such articles on mucosis or keratin materials to achieve a desired result or benefit and to methods of making such adhesive articles. | 05-19-2011 |
20110117175 | SWEET ANALGESIC FOR USE IN MEDICAL PROCEDURES OR TREATMENTS - Sweet analgesics and compositions comprising a sweet analgesic and a delivery vehicle for reducing pain or discomfort associated with a medical procedure or treatment are disclosed. The sweet analgesic is administered or delivered to the intra-oral cavity of the patient prior to or during the medical procedure or treatment to increase the comfort of the patient. The sweet analgesic can be applied to a dental roll or pad and the roll or pad can be inserted between the cheek and gum of the patient to allow for the release of the sweet analgesic during the medical procedure or treatment. The dental roll or pad can be replaced as necessary to maintain the release of the sweet analgesic into the intra-oral cavity of the patient during the medical procedure or treatment. | 05-19-2011 |
20110117176 | HYDROPHILIC POLYPROPYLENE FIBERS HAVING ANTIMICROBIAL ACTIVITY - Polypropylene fibers and devices that include a fatty acid monoglyceride added to the polypropylene as a melt additive are described. A hydrophilic enhancer material can be advantageously added to the polypropylene as a melt additive to enhance the hydrophilicity of the fibers and devices. An antimicrobial enhancer material can be added to the fibers to enhance the antimicrobial activity. | 05-19-2011 |
20110117177 | Method for producing a multilayer compound on a CIP-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavities - Methods for producing a mono- or multilayer composite are provided in which one or several layers are applied onto a carrier material by coating, the coated mono- or multilayer composite is dried and rolled up, and the installation is subsequently cleaned. The air circuit in the drying oven is entirely set to fresh air supply, and the drying oven is configured to be cleaned in a controlled manner. All components of the drying oven that come into contact with the product do not have to be removed during cleaning, but can be cleaned-in-place using technology integrated into the drying oven. The drying oven Outer housing is designed so that it can be lifted upwardly. All assembly parts in the drying oven interior are designed to eliminate disassembling for cleaning purposes. Transport rollers within the drying oven are designed as hollow shafts and provided with spraying nozzles. | 05-19-2011 |
20110123595 | Personal Stimulating Wiping Systems - A wipe to stimulate a person. The wipe is permeated with a smelling salt solution. The smelling salt solution delivers an effective amount of ammonium gas to stimulate the respiratory system of the person. The smelling salt solution delivers an effective amount of alcohol to provide a cooling sensation on the skin. The wipe is contained in a container impermeably to prevent evaporation of the smelling salt solution and to delay transformation of the smelling salts solution to ammonium gas until the container may be opened by the person. Other embodiments and uses are disclosed. | 05-26-2011 |
20110129519 | Modafinil-Based Treatment For Premature Ejaculation - Methods and compositions comprising modafinil are described for treating premature ejaculation in a male individual. | 06-02-2011 |
20110135709 | ADHESIVE SKIN PATCH - The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms. | 06-09-2011 |
20110142909 | WATER-DISPERSIBLE AND MULTICOMPONENT FIBERS FROM SULFOPOLYESTERS - Disclosed are water-dispersible fibers derived from sulfopolyesters having a Tg of at least 25° C. The fibers may contain a single sulfopolyester or a blend of a sulfopolyester with a water-dispersible or water-nondispersible polymer. Also disclosed are multicomponent fibers comprising a water dispersible sulfopolyester having a Tg of at least 57° C. and a water non-dispersible polymer. The multicomponent fibers may be used to produce microdenier fibers. Fibrous articles may be produced from the water-dispersible fibers, multicomponent fibers, and microdenier fibers. The fibrous articles include water-dispersible and microdenier nonwoven webs, fabrics, and multilayered articles such as wipes, gauze, tissue, diapers, panty liners, sanitary napkins, bandages, and surgical dressings. Also disclosed is a process for water-dispersible fibers, nonwoven fabrics, and microdenier webs. The fibers and fibrous articles have further applications in flushable personal care and cleaning products, disposable protective outerwear, and laminating binders. | 06-16-2011 |
20110150972 | MEDICAL DEVICES HAVING IMPROVED PERFORMANCE - According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent. | 06-23-2011 |
20110159074 | Wipe Article Comprising Lotion Composition Comprising Omega-6 Fatty Acid And Method Of Improving Skin Barrier Function - A wipe article comprising a composition comprising omega-6 fatty acid. A method of improving skin barrier function of semi-occluded skin comprising the step of contacting the semi-occluded skin with a wipe comprising an omega-6 fatty acid. | 06-30-2011 |
20110159075 | COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE - Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures. | 06-30-2011 |
20110171282 | Materials Comprising Water-Soluble Polymer Particles and Methods of Making and Using Them - One aspect of the invention relates to new materials for storing, protecting, selectively releasing, and applying active ingredients (e.g. pharmaceuticals and other chemicals). In certain embodiments, the invention provides materials impregnated with water-soluble polymer particles which contain active ingredients which may be selectively released and dispensed in response to contact with water or another liquid. | 07-14-2011 |
20110195108 | ANTIVIRAL AGENT - An antiviral agent is provided which can inactivate a wide range of viruses. Products that include such an antiviral agent are also provided. | 08-11-2011 |
20110212156 | Use of a mixture of two or more enteric materials to regulate drug release via membrance or matrix for systemic therapeutics - Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by having a sustained release profile at lower pH and an accelerated dissolution profile at higher pH. | 09-01-2011 |
20110212157 | DERMAL DELIVERY - The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm. | 09-01-2011 |
20110212158 | IMMUNOCOMPATIBLE CHORIONIC MEMBRANE PRODUCTS - Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment. | 09-01-2011 |
20110217356 | CONTROLLED DELIVERY SYSTEM - Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of interest (e.g., in vivo or in vitro). In some embodiments, the composition is a composition formulated for controlled release of the compound of interest. | 09-08-2011 |
20110217357 | METHOD FOR SOLUBILIZING METRONIDAZOLE - Metronidazole is solubilized in an aqueous phase, by mixing same with niacinamide and at least two glycolic cosolvents; the resulting solutions and pharmaceutical compositions comprised thereof are useful for the treatment of dermatological conditions/afflictions, notably rosacea. | 09-08-2011 |
20110229551 | DRUG DELIVERY COMPOSITIONS AND METHODS USING NANOFIBER WEBS - Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prostheses, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, both non-biodegradable or biodegradable, and derived from synthetic or natural sources. | 09-22-2011 |
20110236464 | MEMBRANE - The invention relates to a membrane for supporting cells, especially RPE cells. The membrane is useful in the treatment of conditions such as age related macular degeneration. | 09-29-2011 |
20110236465 | MELT-EXTRUDED FILM - A mono-layer or multi-layer film wherein at least one of the layers has a thickness of at least 0.125 mm is produced from a melt-extruded polymer composition comprising a) a water-soluble polymer, b) an active ingredient and c) an adjuvant selected from the group consisting of mono- and disaccharides, sugar alcohols, low molecular weight water soluble polymers, and salts of cross-linked carboxymethylcellulose, with the proviso that the adjuvant c) is different from the water-soluble polymer a). | 09-29-2011 |
20110244019 | ABSORBENT FABRIC IMPLANT - Disclosed is a method and device for treating a tissue defect, disease or abnormality. The device includes an absorbent container adapted to be placed at a tissue site, the container constructed and arranged to absorb a bioactive solution prior to the placement at the tissue site and to carry the solution to the tissue site such that the solution interacts with the tissue and wherein the absorbent container is substantially free of a metal support structure. The method includes providing an absorbent container substantially free of a metal support structure, soaking the container in a bioactive solution such that the solution is absorbed by the container and placing the container at the tissue site such that the solution interacts with the tissue. | 10-06-2011 |
20110244020 | DRUG CONDENSATION AEROSOLS AND KITS - The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits. | 10-06-2011 |
20110244021 | ANTIMICROBIAL AND IMMUNOSTIMULATING COMPOSITION - A medical composition comprising an antimicrobially effective and immunostimulating amount of a combination of a β-glucan component and a silver-containing component is disclosed. The medical composition may be adapted for use topically or incorporated with a mesh material which may be further adapted for use as a wound dressing or as a surgical mesh. Methods for manufacturing the medical compositions described herein are also provided. The invention further provides methods for treating tissue damaged by wound or burn, and methods for treating or repairing tissue at a surgical site. | 10-06-2011 |
20110250257 | FIBROUS TISSUE SEALANT AND METHOD OF USING SAME - Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds. | 10-13-2011 |
20110262520 | LAYERED DRUG DELIVERY DEVICE - The layered drug delivery devices of the present invention have an outer side and an inner side. The device includes, in order from the outer side to the inner side, a first layer and a second layer. The first layer wherein the first layer is water insoluble, water swellable, and water permeable. The second layer includes a therapeutic amount of a water soluble drug and a water soluble mucoadhesive film. The second layer is disposed such that water passing through said first layer solubilizes the drug. The said solubilized drug then can permeate through a mucosal membrane when the inner side is in contact with the mucosal membrane. The drug delivery device is in sheet form. | 10-27-2011 |
20110262521 | MEDICAL DEVICE INCLUDING BACTERIAL CELLULOSE REINFORCED BY RESORBABLE OR NON RESORBABLE REINFORCING MATERIALS - The present invention relates to a medical device comprising: a reinforcing member; and bacterial cellulose on at least a portion of the reinforcing member. The invention also relates to a method for making such a medical device. | 10-27-2011 |
20110268784 | CLAY-BASED HEMOSTATIC AGENTS AND DEVICES FOR THE DELIVERY THEREOF - A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate. | 11-03-2011 |
20110274742 | Cartilage Repair Systems and Applications Utilizing A Glycosaminoglycan Mimic - The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and, in certain aspects, a fibrous or filamentous matrix. The hydrogels as described provide a support or scaffold that promotes, facilitates, and/or enhances progenitor or stem cell growth and/or differentiation. In addition, the hydrogel is useful for tissue, e.g., cartilage, regeneration and repair. | 11-10-2011 |
20110274743 | Medicament for the Treatment of Pain and Inflammation - The use of vitamin D3 for the manufacture of a medicament for the transdermal treatment of neurogenic inflammation and neuropathic pain (including peripheral neuropathic pain); also a method for the relief of neurogenic inflammation and neuropathic pain using this medicament. | 11-10-2011 |
20110280924 | Biodegradable filler for restoration of alveolar bones - A biodegradable filler for restoration of alveolar bones is disclosed, which includes: first cross-linked collagen fibers prepared from reacting Non-crosslinked collagen fibers with a cross-linking agent; and supporting particles which are biomedical ceramic particles, bioactive glass, or a combination thereof, and distributed among the first cross-linked collagen fibers. | 11-17-2011 |
20110280925 | Dual And Single Layer Dosage Forms - Provided is a dual-release, dual-adhesiveness flexible thin film dosage form comprising: a quick-release subfilm comprising an admixture of polymer, which comprises predominantly highly water-soluble polymer(s), and a bioactive agent, the polymers and other components of the quick-release subfilm adapted to provide 20 minute or less erodibility for the quick-release subfilm; and laminated against the quick-release subfilm, a sustained-release subfilm comprising an admixture of polymer, which comprises predominantly hydrophilic, bioadhesive polymer(s), and a second bioactive agent, which can be the same as the first, the polymers and other components of the sustained-release subfilm adapted to provide erodibility of 1 hours or more and 20 hours or less for the sustained-release subfilm, the dosage form having a thickness of 30 mil or less, and being more adhesive on the sustained-release side. | 11-17-2011 |
20110293690 | Biodegradable Polymer Encapsulated Microsphere Particulate Film and Method of Making Thereof - Films containing microsphere particles and processes for forming thereof are disclosed. The microsphere particles encapsulate one or more bioactive agents and may be deposited on a surface of medical devices or be used to form a medical device. | 12-01-2011 |
20110293691 | MULTIMODAL ADHESION BARRIER - Provided herein are multimodal barrier materials useful for preventing adhesions in a subject, which may include a collagen, a collagen deposition inhibitor and/or a chitosan. | 12-01-2011 |
20110311608 | STABLE CHITOSAN HEMOSTATIC IMPLANT AND METHODS OF MANUFACTURE - Implantable hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of implantable medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of internal bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, dressings, wound plugs, incision plugs, arteriotomy plugs, tissue fillers, sealers, sheets, rolls, combinations thereof, and the like. | 12-22-2011 |
20110311609 | Wound healing device - The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix. | 12-22-2011 |
20110318403 | Preparation and Use of Pouteria Lucuma Extract - A method of preparing | 12-29-2011 |
20120009240 | Films for Delivery of a Therapeutic Agent - The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the multilayer films are also disclosed. | 01-12-2012 |
20120021041 | TRANSDERMAL DELIVERY - Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval. | 01-26-2012 |
20120027837 | MULTILAYER COATING COMPOSITIONS, COATED SUBSTRATES AND METHODS THEREOF - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a first plurality of first units, each first unit comprising a protamine polypeptide. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for release and a first plurality of first unit; each first unit comprising a first layer and a second layer, wherein the first layer and the second layer are associated with one another. | 02-02-2012 |
20120027838 | FILAMENTS COMPRISING AN INGESTIBLE ACTIVE AGENT NONWOVEN WEBS AND METHODS FOR MAKING SAME - Filaments containing a filament-forming material and an additive, such as an ingestible active agent, nonwoven webs, and methods for making such filaments are provided. | 02-02-2012 |
20120034291 | NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS - The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass sition temperature of the silk film Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices. | 02-09-2012 |
20120034292 | Composition For Transdermal Delivery Of Fentanyl - A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl. | 02-09-2012 |
20120039982 | Bio-Sheet for Eye Tissue Repair - A bio-sheet applied on the eye tissue repair is disclosed. The bio-sheet comprises a biodegradable substrate formed of fish scales and has an epithelial cell layer formed thereon, wherein the fish scales are bony scales. | 02-16-2012 |
20120045500 | NOVEL DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM - Compounds of general formula (I): | 02-23-2012 |
20120058174 | FABRICATION OF INTERCONNECTED MODEL VASCULATURE - Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a non-woven fiber network comprising a plurality of fibers and a void space; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network. | 03-08-2012 |
20120058175 | Transdermal Preparation - Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer. | 03-08-2012 |
20120064144 | METHOD OF TREATING ECZEMA - The present invention relates to the treatment of eczema. More specifically, the invention relates to a new method of treating eczema through the epicutaneous route. In particular, the method of the invention comprises applying to a non eczematous area of the skin of the subject a skin patch device, comprising a composition, under conditions allowing a contact between said composition and the skin. The present invention also relates to the skin patch device. | 03-15-2012 |
20120070485 | METHOD FOR PRODUCING A DEVICE APPLICABLE TO BIOLOGICAL TISSUES, PARTICULARLY A PATCH FOR TREATING DAMAGED TISSUES, AND A DEVICE OBTAINED BY SAID METHOD - The present invention relates to a device consisting of cross-linked nanofibrillary fibrin supported on and rooted to a microporous nonwoven fabric consisting of a biocompatible synthetic polymer material. An active ingredient is advantageously dispersed in the fibrin layer. The fibrin layer does not have a haemostatic function, but is suitable for retaining the active ingredient and releasing it with controlled kinetics. The device forming the object of the invention, preferably in the form of patches, is useful for in vitro cell cultures or for treating tissues damaged by wounds or necrosis, such as cardiac walls bearing the sequelae of infarction, or a tissue damaged by a diabetic ulcer. The patch according to the invention can be manufactured by inducing the polymerisation of the fibrin, under suitable conditions, directly on the support layer, which is suitably impregnated with thrombin (at least in a superficial portion of its thickness), and which has been conveniently prepared by means of a spray phase-inversion technique. | 03-22-2012 |
20120076850 | Topical Patch For Pain Relief Using Cooling Agent - Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications. | 03-29-2012 |
20120082714 | TRANSDERMAL THERAPEUTIC SYSTEM WITH CRYSTALLIZATION-INHIBITING PROTECTIVE FILM (RELEASE LINER) - The invention relates to pharmaceutical formulations, in particular to transdermal therapeutic systems, which are characterized in that little or no active ingredient crystallizes out at the interface between the removable protective film (release liner) and the active-ingredient-containing matrix. | 04-05-2012 |
20120093912 | Biomimetic Nanofiber Web And Method And Device To Manufacture The Same - A method for forming nanofiber web comprises the steps of: mixing ( | 04-19-2012 |
20120100202 | MANUFACTURING OF SMALL FILM STRIPS - The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate via the use of individual pumps to deposit individual wet film products onto a substrate. | 04-26-2012 |
20120100203 | Fabrication of Biscrolled Fiber Using Carbon Nanotube Sheet - Fabrication of yarns or other shaped articles from materials in powder form (or nanoparticles or nanofibers) using carbon nanotube/nanofiber sheet as a platform (template). This includes methods for fabricating biscrolled yarns using carbon nanotube/nanofiber sheets and biscrolled fibers fabricated thereby. | 04-26-2012 |
20120107387 | LAMINATED SHEET AND PROCESS FOR PRODUCING THE SAME - A laminated sheet is produced by forming an adhesion layer permeable to a liquid component and contactable with a skin on at least one side of a liquid-retention layer comprising a nonwoven structural member and having an ability to absorb the liquid component. The adhesion layer comprises a nonwoven structural member comprising a fiber having a number-average fiber diameter of not more than 10 μm, and the thickness ratio of the adhesion layer relative to the liquid-retention layer is 1/4 to 1/100 as a ratio of the adhesion layer/the liquid-retention layer. The fiber of the nonwoven structural member of the adhesion layer may have a standard deviation of fiber diameter of not more than 5. The nonwoven structural member of the liquid-retention layer may comprise a fiber having a fiber diameter larger than that of the fiber of the adhesion layer. The laminated sheet has a liquid retentivity and a liquid releasability in a well-balanced manner, and has an excellent adhesion and an excellent fit to the skin in the state where the sheet is impregnated with a liquid component. | 05-03-2012 |
20120114736 | ZEOLITE COMPOSITE MATERIALS FOR WASTE ODOR CONTROL - A composite material for environmental odor control is useful in controlling odors from waste, for example, as an alternative daily cover for landfills and in composting applications. The composite material includes a fiber web and a zeolite containing metals to promote absorption of odorous gas. | 05-10-2012 |
20120121686 | BIODEGRADABLE COMPOSITIONS HAVING PRESSURE SENSITIVE ADHESIVE PROPERTIES - A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue. | 05-17-2012 |
20120128753 | MEDITOWEL PRE-PACKAGED MEDICATED MUSCLE AND JOINT PAIN RELIEF WIPE - Single use, substrate uniformly impregnated with an anhydrous muscle and joint pain relief solution for the use of aseptically delivering a single dose of a muscle and joint pain relief solution to the area of pain. Solution and substrate is contained encapsulated within a heat sealed foil enclosure that is stable for at least five years. | 05-24-2012 |
20120128754 | TREATMENT OF EYE DISCOMFORT BY TOPICAL ADMINISTRATION OF A COOLING AGENT TO THE EXTERNAL SURFACE OF THE EYELID - The present invention pertains generally to the field of ocular treatment, and more specifically to the use of a liquid cooling agent composition comprising a cooling agent for the treatment of (e.g., the alleviation of symptoms of; the amelioration of) eye discomfort. The preferred cooling agent is (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarboxylic acid 2,3-dihydroxy-propyl ester (referred to herein as CPS-030). The liquid cooling agent composition is topically administered to at least a portion of the external surface of the eyelid (preferably the closed eyelid) of the eye to be treated. Preferably, the liquid cooling agent composition is carried on or in a wipe, pad, or towelette, for example, an eye wipe. | 05-24-2012 |
20120141575 | Collagen For Use In The Treatment Of Skin Diseases - The invention relates to collagen for use in the treatment of inflammatory and degenerative skin diseases and damage to the skin connected therewith, such as in particular in the treatment of psoriasis, dermatitis, neurodermitis, rosacea, urticaria (hives), pruritus (itching), skin eczema and actinic keratosis. In particular, the invention relates to freeze-dried collagen in the form of layered dressings, sheets, pads or masks for the aforementioned use. | 06-07-2012 |
20120148656 | SHEET-FORM PREPARATION AND METHOD FOR PRODUCING THE SAME - The present invention provides a sheet-form preparation that can be easily dissolved intraorally, allows the dissolution time thereof to be easily controlled, and can stably contain a drug except an allergenic protein from cedar pollen. The sheet-form preparation contains water, gelatin, and a drug except an allergenic protein from cedar pollen. | 06-14-2012 |
20120156278 | SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE - A method of regenerating tissue in a living organism. The method includes the act of contacting an affected area of the living organism with a solid-fibrin web, the solid-fibrin web comprising platelets that release growth factors about one minute after contact to regenerate the tissue in the living organism. | 06-21-2012 |
20120171274 | TRANSDERMAL PATCH - The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester. | 07-05-2012 |
20120171275 | Local administration of gallium compositions to treat pain - Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms. | 07-05-2012 |
20120177718 | WOUND-COVERING MATERIAL - A new wound-covering material that protects and repairs a wound area caused by an operation, trauma, burn, and the like is provided. The present invention relates to a wound-covering material comprising thrombin, fibrinogen and a bioabsorbable supporting material. The wound-covering material may further be overlaid with a covering material for retaining moisture. The wound-covering material may be consisted of a kit of either (1) a bioabsorbable supporting material holding thrombin, and fibrinogen; or (2) a bioabsorbable supporting material holding thrombin, and a bioabsorbable supporting material holding fibrinogen; or (3) thrombin, fibrinogen and a bioabsorbable supporting material. Besides, each of the kits may be combined with a covering material for retaining moisture. | 07-12-2012 |
20120183594 | Method of increasing photosynthesis and reducing ozone - A method of protecting plants from ozone by applying to the photosynthetically active portions of said plants a particle film containing particles, an effective amount of a volumizing and two or more of nitrogen-rich carbonaceous materials which destroy ozone, microbial fertilizer which promotes microbial growth in the particle film, and ozone-reactable carbonaceous materials coated on the particles. | 07-19-2012 |
20120183595 | Transdermal Pharmaceutical Delivery Composition - A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent. | 07-19-2012 |
20120189684 | Skincare Compositions - This invention relates to skincare compositions, in particular compositions effective in the treatment of acne vulgaris, and to methods of treatment of the skin that involve the application of such compositions, wherein the compositions comprise salicylic acid or a salt thereof in combination with at 2 actives selected from the group consisting of lactic acid or a salt thereof; glycyrrhizinic acid or a salt or derivative thereof; bisabolol; cetylhydroxyproline palmitamide; allantoin; niacinamide; and epilobium angustifolium extract. | 07-26-2012 |
20120195953 | Fibrin sealant (FIBRINGLURAAS) consisting of a kit of lyophilized high concentrate fribinogen intentionally enriched and preserved with fibronolysis inhibitor A1AT - Fibrin sealant (FIBRINGLURAAS®) consisting of a kit of lyophilized high concentrate fribinogen intentionally enriched and preserved with fibronolysis inhibitor A1AT, either non-heated or heating to at least 1° C. and above, preferably at least 101° C., and lyophilized thrombin used to compound glue membrane, the diameter of which is less than 10 micrometers the actual size of the glue membrane of the fibrin sealant (FIBRINGLURAAS®) is from 0.6 μm, to 101° C. heating 0.005 micrometers. Thrombin, a protein, contains good healthy cells. High concentrate fibrinogen, another protein, contains good healthy cells. AFOD (HDL ApoA1), another protein, contains good healthy cells and its topical applications for all solid tumor cancers. | 08-02-2012 |
20120195954 | Method of Reducing Appetite - Provided, among other things, is a method of reducing dietary intake comprising: | 08-02-2012 |
20120195955 | SUBLINGUAL FILMS - The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith. | 08-02-2012 |
20120207811 | Textile material for management of skin health complications associated with skin folds, and its method of use - A device configured to manage skin health within a skin fold includes a textile material having an antimicrobial silver complex and a liquid translocation feature. The liquid translocation feature is characterized by a transportation of at least 1.0 gram of liquid moisture over at least a 12 cm length of the textile material such that the textile material is configured to concurrently treat moisture accumulation and intertrigo within the skin fold. | 08-16-2012 |
20120207812 | SKINCARE COMPOSITIONS COMPRISING SALICYCLIC ACID - There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises salicylic acid or a salt thereof and hydrolysed milk protein. The composition is useful in the treatment of acne. | 08-16-2012 |
20120207813 | RAPIDLY ACTING DRY SEALANT AND METHODS FOR USE AND MANUFACTURE - Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties. | 08-16-2012 |
20120207814 | AQUEOUS PATCHES CONTAINING DICLOFENAC SODIUM - An aqueous patch containing diclofenac sodium, wherein the patch contains a homogeneous mixed solution of diclofenac sodium, wherein the solution is obtained by mixing crotamiton, diclofenac sodium and water in the mixture ratio of crotamiton/diclofenac sodium of 8.0 or less and the mixture ratio of (water+crotamiton)/diclofenac sodium of 3.0-20.0. | 08-16-2012 |
20120213842 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS - The subject invention relates to novel micoparticulate and soluble forms of flavonoids, and their synthesis. The invention also includes novel formulations of such flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations. | 08-23-2012 |
20120225110 | PATCH AND PATCH PREPARATION - A patch according to an embodiment of the present invention includes a support and a pressure-sensitive adhesive layer provided on at least one surface of the support. The pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing a monomer mixture containing (a) a (meth)acrylic acid alkyl ester, (b) a hydroxyl group-containing monomer, and (c) a diketone group-containing monomer. | 09-06-2012 |
20120231062 | ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS - Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions. | 09-13-2012 |
20120251610 | NICOTINE-CONTAINING PATCH PREPARATION - An object of the present invention is to provide a nicotine-containing patch preparation which enables to suppress degradation of nicotine and coloring of the patch preparation. The present invention provides a patch preparation comprising a support and an adhesive layer on its at least one surface, wherein the adhesive layer comprises an adhesive polymer, nicotine and a stabilizer, and the stabilizer is at least one kind selected from the group consisting of butylhydroxyanisole (BHA), propyl gallate (PGA), dibutylhydroxytoluene (BHT) and 2-mercaptobenzimidazole (MBI). | 10-04-2012 |
20120251611 | SUPER-HYDROPHILIC STRUCTURES - A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film. | 10-04-2012 |
20120258164 | TRANSDERMAL GRANISETRON - Adhesive patches for the transdermal administration of granisetron, comprise an acrylic adhesive containing non-acidic nucleophilic moieties which substantially increase flux of granisetron across the skin. | 10-11-2012 |
20120263780 | Carbohydrate Entrapped Active Agent Delivery Composition and Articles Using the Same - Delivery compositions and substrates for imparting a volatile active agent to a surface are disclosed herein. To achieve the delivery of the volatile component, a delivery composition of a carbohydrate matrix and a volatile component is incorporated into the carbohydrate matrix to stabilize the volatile for extended periods of time. The delivery composition further comprises a self-generating expelling agent to expel the volatile component onto the contaminated surface or skin upon addition of a triggering agent. | 10-18-2012 |
20120276188 | BIOMATERIALS MADE FROM HUMAN HAIR - A hydrogel that comprises denatured human hair biomolecules intermolecularly crosslinked with disulfide bonds to form a hydrogel. The hydrogel may be prepared by reduction and denaturation of hair to provide keratins and other hair biomolecules that are crosslinked by the disulfide bonds to provide a firm, flexible, and useful biomaterial. | 11-01-2012 |
20120282318 | SHEET FOR CORNEAL TRANSPLANTS - The present invention relates to a sheet for corneal transplants comprising corneal endothelial cells on a gelatin hydrogel, which is obtainable by seeding and culturing corneal endothelial cells on a gelatin hydrogel coated with collagen. The sheet of the present invention is extremely useful as a sheet for corneal transplants not only for its biocompatibility and biodegradability, but also for its high transparency. | 11-08-2012 |
20120282319 | LOTIONED WIPE PRODUCT TO REDUCE ADHESION OF SOILS OR EXUDATES TO THE SKIN - An anti-stick agent that may be incorporated into an aqueous medium to assist in the prevention of soils and bodily exudates adhering to the skin. A substrate may be utilized to assist in delivering the anti-stick agent to the skin. | 11-08-2012 |
20120294926 | TWO OR MORE VOLATILE SOLVENT-CONTAINING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS - The present invention is drawn to adhesive formulations and methods of drug delivery. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least two volatile solvents, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 11-22-2012 |
20120301535 | COMBINATION PEPTIDE-NANOPARTICLES AND DELIVERY SYSTEMS INCORPORATING SAME - Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms. | 11-29-2012 |
20120301536 | ANTI-MICROBIAL TISSUE PAPER AND PROCESS TO MANUFACTURE SAME - An antimicrobial paper includes a paper web having a grammage between 10 and 60 grams per square meter, a cationizing agent in a concentration ranging between 0.05 wt % and 5 wt %, an antimicrobial agent in a concentration ranging between 0.01 wt % and 3 wt %, the antimicrobial agent and the cationizing agent being added on the paper web having a consistency above 15 wt %, the antimicrobial paper having an antimicrobial agent release of above about 0.01 wt % when wetted. | 11-29-2012 |
20120308635 | MELT EXTRUDED THIN STRIPS CONTAINING COATED PHARMACEUTICAL - A composition suitable for hot melt extrusion to form thin strips containing active pharmaceutical ingredients is provided. The composition has 10 to 75% by weight of polyethylene oxide having a molecular weight of from 70,000 to 230,000 Daltons; 5 to 35% of a sugar alcohol having a melting point in excess of 75° C.; 5 to 20% by weight of polyethylene glycol having a molecular weight of from 100 to 4,000 Daltons; and 10 to 75% by weight of coated active pharmaceutical ingredient (API). | 12-06-2012 |
20120315318 | TRANSDERMAL PREPARATION - A transdermal preparation comprising a multivalent metal chloride, a basic drug having an amino group, and an ester group-containing base material, is useful because of its excellent drug content stability. | 12-13-2012 |
20120315319 | GUIDED BONE REGENERATION MEMBRANE AND MANUFACTURING METHOD THEREOF - A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electro spinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability. | 12-13-2012 |
20120321690 | ADHESIVE PATCH - The present invention provides a patch having a backing and a pressure-sensitive adhesive layer on the backing, wherein the pressure-sensitive adhesive layer contains a pressure-sensitive adhesive base composed of a polymer having a hydroxyl group, a drug, polyvinylpyrrolidone and a multivalent metal chloride. | 12-20-2012 |
20120328688 | BIOCOMPATIBLE FILM WITH VARIABLE CROSS-SECTIONAL PROPERTIES - A biocompatible film includes a single layer having a plurality of components, at least one of the plurality of components having a predetermined non-uniform distribution in the thickness direction of the single layer. The at least one of the plurality of components that has a non-uniform distribution in the thickness direction of the single layer may have a substantially uniform distribution in the longitudinal and lateral directions of the single layer. The biocompatible film can be made by depositing a fluid composition including a film forming material and at least one other component immiscible with the film forming material and having a density different than the film forming material into a single layer, and drying the single layer such that the at least one other component has a predetermined non-uniform distribution in the thickness direction of the single layer after drying. | 12-27-2012 |
20120328689 | DEODORIZING PAPER AND METHOD - A deodorizing paper substrate is provided that has a base sheet that incorporates between 3%-15% of sodium bicarbonate. The deodorizing particles remove malodors from any environment. An associated method of manufacture is also provided. | 12-27-2012 |
20130004560 | Polymer Nanofilm Coatings - Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications. | 01-03-2013 |
20130011462 | MELT EXTRUDED NICOTINE THIN STRIPS - A thin strip for oral ingestion is between 0.05 millimeters and 2.00 millimeters thick. It includes 10 to 80% by weight of polyethylene oxide having a molecular weight of from 70,000 to 300,000 daltons. It further includes 5 to 50% by weight of a sugar alcohol having a melting point in excess of 75 C and 5 to 30% by weight of polyethylene glycol having a molecular weight of from 200 to 1,000 daltons. Lastly it includes 1 to 30% by weight of a carboxy vinyl polymer cross linked with an allyl ether of pentaerythritol, and 1 to 10% by weight of an organic acid addition salt of nicotine. | 01-10-2013 |
20130011463 | METHOD AND DEVICE FOR SYNOVIAL CELL-CHARGED COLLAGEN MEMBRANE OR GEL - An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device. | 01-10-2013 |
20130017245 | SOLID PREPARATIONAANM Takano; YouichiAACI Itabashi-kuAACO JPAAGP Takano; Youichi Itabashi-ku JP - The present invention relates to a solid preparation having an easily controllable elution property of a drug, and a method for improving dissolution of a drug. | 01-17-2013 |
20130028953 | Transdermal Delivery Systems for Sufentanil - Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided. | 01-31-2013 |
20130034595 | Local administration of gallium compositions to treat pain - Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms. | 02-07-2013 |
20130039967 | ORAL DOSAGE FORMS - The invention relates to specific three layer dosage forms for oral administration of pharmaceutical active substances. | 02-14-2013 |
20130045267 | METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION - Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen presenting cells (e.g., dendritic cells and Langertians cells), by either increasing or decreasing expression of claudin-1 and/or claudin-23. Also provided are transdermal formulations that decrease expression of claudin-1 and/or claudin-23, thereby diminishing tight junction formation in cells expressing claudin-1 and/or claudin-23, as well as a transdermal patch for delivering the same. | 02-21-2013 |
20130045268 | ABUSE-RESISTANT MUCOADHESIVE DEVICES FOR DELIVERY OF BUPRENORPHINE - The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized. | 02-21-2013 |
20130064875 | COMPOSITION FOR ENHANCING TRANSDERMAL ABSORPTION OF A DRUG AND PATCH PREPARATION - The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug. | 03-14-2013 |
20130064876 | PROCESS OF TREATMENT OF FIBERS AND/OR TEXTILE MATERIALS - A process of treatment of textile materials containing microcapsules of active ingredients, the fibers and/or textile materials resulting from this process and their cosmetic or pharmaceutical use and/or their use as a repellent. | 03-14-2013 |
20130064877 | COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL - A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl. | 03-14-2013 |
20130071464 | COMPOSITION COMPRISING PHOSPHONIC ACID POLYMER FOR USE AS TISSUE ENGINEERING FIBROUS SCAFFOLD - A fibrous tissue scaffold wherein fibres of the scaffold comprise a phosphonic acid polymer. The fibres preferably incorporate a vinylphosphonic acid—acrylic acid copolymer, and may further include polycaprolactone. There is further described medical implant coating comprising a phosphonic acid polymer, a biocompatible fibre comprising a phosphonic acid polymer and a biocompatible polymer comprising polycaprolactone and a phosphonic acid polymer. | 03-21-2013 |
20130078299 | Transdermal Patches Having Ionized Beam Crosslinked Polymers and Improved Release Characteristics - Crosslinked hydrogel-based transdermal pharmaceutical formulations. The hydrogel transdermal formulations. Transdermal patches are useful for administering a variety of drugs to patients. The transdermal patches here employ crosslinked-hydrogels generated through irradiation, thus eliminating any residual effects associated with chemical- or UV-based crosslinking procedures. The transdermal patches may be formed from a variety of high-molecular weight polymeric compounds and include substantial levels of water to improve skin tolerance by the patient. The transdermal patches may also include transcutol as a solvent for the drug, which has been found to increase the effectiveness of drug delivery. The present disclosure also provides for methods of loading a drug into a transdermal formulation after the crosslinking of the hydrogel, thus improving stability and bioavailability through avoiding exposure of the drug to the radiation used in the crosslinking procedure. The transdermal patches here are particularly effective in delivering lidocaine to patients in need thereof. | 03-28-2013 |
20130089595 | Controlled Release Formulations - The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or controlled release of the incorporated compounds as the hydrogel is degraded in the body. | 04-11-2013 |
20130095165 | STABILIZERS FOR HEMOSTATIC PRODUCTS - A hemostatic product that includes a dextran support, at least one hemostatic agent and at least one hemostatic agent stabilizer. The at least one hemostatic agent is selected from the group consisting of thrombin and fibrinogen. The at least one hemostatic agent is associated with the dextran support. The at least one hemostatic agent stabilizer is associated with the at least one hemostatic agent. | 04-18-2013 |
20130095166 | ADHESIVE COMPOSITION FOR MEDICAL USE, PATCH FOR MEDICAL USE, AND METHOD FOR PRODUCING THE COMPOSITION - An adhesive composition for medical use of the present invention includes an acrylic copolymer, a medicament having a carboxyl group, and a base, the acrylic copolymer is prepared by copolymerization of a monomer mixture containing 0.1 to 2 mass % of an ethylenically unsaturated carboxylic acid monomer as a monomer A, 58 to 99.9 mass % of an alkyl(meth)acrylate ester having an alkyl group of 4 to 12 carbon atoms as a monomer B, 30 mass % or less of an alkyl(meth)acrylate ester having 1 to 3 carbon atoms as a monomer C, and 30 mass % or less of a monomer having an ethylenically unsaturated group other than those of the monomers A to C (the total of monomers A to D is taken as 100 mass %) as a monomer D, and the content of sulfuric acid in the acrylic copolymer is 700 ppm by mass or less. | 04-18-2013 |
20130095167 | CUSTOMIZED COMPOSITIONS AND USES THEREOF - The present invention relates to a customized composition comprising three-dimensional (3D) nanofiber webbing. The present invention further relates to the process of producing the composition comprising 3D nanofiber webbing and uses thereof such as treatment of age-related macular degeneration or regeneration/repair of tissue. | 04-18-2013 |
20130101659 | CELL SHEET FOR MYOCARDIAL REGENERATION, METHOD OF PRODUCING THE SAME, AND METHOD OF USING THE SAME - Provided are a cell sheet and a three-dimensional structure thereof that include at least mesenchymal stem cells and myoblasts isolated from a cell culture support and that are to be applied to heart disease. Use of the cell sheet and the three-dimensional structure thereof including mesenchymal stem cells and myoblasts can notably improve cardiac functions compared with a conventional technology, i.e., use of cell sheets composed of myoblasts only or mesenchymal stem cells only. Furthermore, the cell sheet itself has high strength, and the transplantation procedure is also improved. | 04-25-2013 |
20130115267 | COMPOSITIONS AND METHODS FOR REDUCING EDEMA - The invention provides compositions and methods for the treatment and/or reversal of an edema, e.g., including a central nervous system (CNS) edema, e.g., a brain or a spinal edema, edema in a burned or an injured tissue such as skin, or any tissue edema. In alternative embodiments, the invention provides compositions and methods for a direct treatment and reversal of an edema, e.g., CNS, brain or spinal edema, including a membrane transport device, in vitro and in vivo characterization of edema, and the sensitive early optical detection of the edema, e.g., tissue, CNS or cerebral edema. | 05-09-2013 |
20130115268 | Methods of Administering a Dermatological Agent to a Subject - Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications. | 05-09-2013 |
20130122076 | Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease - The present invention relates to a method and device for treating patients with a Protein Misfolding Disease by chronically administering an effective dose of a thormbolytic reagent over an intermittent period of time. The thrombolytic reagents degrade the misfolded proteins that accumulate and that can become toxic in such patients. The administration is administered transdermally via a transdermal patch that is equipped with an ultrasound transducer for enhancing the penetration of the thrombolytic reagent into the bloodstream of a patient by increasing the permeability of the patient's skin. | 05-16-2013 |
20130122077 | SKIN PATCHES AND SUSTAINED-RELEASE FORMULATIONS COMPRISING LOFEXIDINE FOR TRANSDERMAL AND ORAL DELIVERY - This invention relates to a sustained release oral and transdermal pharmaceutical formulations and delivery systems comprising lofexidine. The invention is also directed to methods of treatment comprising administering lofexidine in a sustained release manner. Such methods can involve administration of the lofexidine containing compositions described herein. Compositions of lofexidine formulated for sustained release delivery are provided. Also provided are methods for the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine. The methods may provide treatment for a variety of conditions amenable to amelioration by lofexidine administration. The methods utilize lofexidine compositions formulated for transdermal and sustained release oral delivery for administration of lofexidine in an amount effective for the treatment of the drug indications. | 05-16-2013 |
20130122078 | COLLAGEN-CONTAINING CELL CARRIER - The present invention relates to a method for the implantation of biological material into an organism. | 05-16-2013 |
20130129807 | COLLAGEN-BASED IMPLANTS FOR SUSTAINED DELIVERY OF DRUGS - The disclosure provides collagen-based constructs for use in drug delivery. | 05-23-2013 |
20130142860 | MATERIAL COMPOSITIONS WHICH COMPRISE ADULT STEM CELLS OBTAINED FROM EXOCRINE GLANDULAR TISSUE, IN PARTICULAR FOR USE IN REGENERATIVE MEDICINE - The invention relates to material compositions comprising adult stem cells obtained from exocrine gland tissue and a supporting matrix having the shape of a thread structure and/or of a net. The supporting matrix preferably consists of a plastic material which is physiologically acceptable and degradable in the body. The material compositions of the invention are in particular suited for use in regenerative medicine, e.g. for regeneration of injured or damaged myocard tissue. | 06-06-2013 |
20130156843 | Artificial Hair Filament Having Antibacterial and Antifungal Properties, Method and Device for Preparing the Same - An artificial hair filament having a core/sheath structure is provided. The artificial hair filament has excellent antibacterial and antifungal effects since antibacterial and antifungal nanoparticles are included in the sheath structure of the artificial hair filament. Here, the antibacterial and antifungal effects can last for a long period of time. A contact-type drug-treating roller and an ultrasonic spraying machine can be used to provide the artificial hair filament with the antibacterial and antifungal effects. In the artificial hair filament, the sheath structure is formed so that the sheath structure occupies 5 to 20% of an entire filament diameter, thereby exhibiting desirable antibacterial and antifungal effects. Therefore, degradation of the antibacterial properties and antifungal properties with time can be prevented. | 06-20-2013 |
20130171231 | Heat Patch For Insomnia - Provided in the present invention are a composition for treating or ameliorating insomnia and methods of making and using the same. | 07-04-2013 |
20130171232 | Heat Patch for Parkinson's Disease - Provided in the present invention are a composition for treating or ameliorating Parkinson's and methods of making and using the same. | 07-04-2013 |
20130177622 | Medicament for the Treatment of Pain and Inflammation - The use of vitamin D3 for the manufacture of a medicament for the transdermal treatment of neurogenic inflammation and neuropathic pain (including peripheral neuropathic pain); also a method for the relief of neurogenic inflammation and neuropathic pain using this medicament. | 07-11-2013 |
20130177623 | Preparation Rich in Growth Factor-Based Fibrous Matrices for Tissue Engeering, Growth Factor Delivery, and Wound Healling - Activated platelet-rich plasma (aPRP) is electrospun into fibrous matrices which are used to deliver components of aPRP to a site of action in a sustained manner. The electrospun matrices are used, for example, for tissue engineering applications and for the treatment of wounds. | 07-11-2013 |
20130183365 | Wound Healing Device and Method - The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof. | 07-18-2013 |
20130189344 | HUMAN LUBRICATION GEL - Human lubricating gels, methods and kits for delivering a therapeutic agent to a target tissue site beneath the skin of a patient utilizing human lubricating gel are provided, the human lubricating gel being capable of adhering to the target tissue site and comprising one or more biodegradable formulations containing an effective amount of the therapeutic agent. In various embodiments, the human lubricating gel is sprayable and hardens after contacting the target tissue site. | 07-25-2013 |
20130189345 | WOUND CARE SYSTEM AND BACTERIDICAL METHODS AND DEVICES - A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO | 07-25-2013 |
20130195953 | METHODS AND FORMULATIONS FOR ADMINISTRATION OF ANTI-INFLAMMATORY COMPOUNDS - The invention relates to resolvins and their use as anti-inflammatory compounds. The resolvins may be administered in a variety of forms, including drug depots comprising polymers or lipids. The pharmaceutical formulations of the present invention may be used to treat a variety of conditions including acute pain and chronic pain. | 08-01-2013 |
20130195954 | FILMS AND PARTICLES - Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses. | 08-01-2013 |
20130195955 | Implants Containing BMP-7 - Osoteogenic implants, and related compositions, methods and kits. The implants comprise a biodegradable scaffold comprising a polycaprolactone matrix and tricalcium phosphate particles within the matrix. The implants further include a formulation comprising BMP-7. | 08-01-2013 |
20130195956 | Transdermal Hormone Delivery - Compositions and devices for transdermal hormone delivery are disclosed. The compositions and devices include desogestrel and enable delivery of effective amounts of progestin without the use of skin permeation enhancers. | 08-01-2013 |
20130195957 | PATCH AND METHOD FOR ENHANCING ADHESION FORCE OF THE SAME - A patch comprising a support and an adhesive agent layer, wherein the adhesive agent layer comprises at least one selected from the group consisting of tolterodine acetate and salts thereof. | 08-01-2013 |
20130202674 | TISSUE PATCH - Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. | 08-08-2013 |
20130202675 | SYSTEMS AND METHODS FOR THE FABRICATION OF TISSUE PATCHES - Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. | 08-08-2013 |
20130202676 | CROSS-LINKED DEHYDRATED PLACENTAL TISSUE GRAFTS AND METHODS FOR MAKING AND USING THE SAME - Described herein are tissue grafts produced by contacting dehydrated placental tissue grafts with a cross-linking agent. The tissue grafts described herein provide barrier and prevent the migration of a bioactive agent from the wound. Thus, the tissue grafts enhance wound healing while preventing the undesirable migration of a bioactive agent from the wound. Methods for making and using the cross-linked grafts are also described herein. | 08-08-2013 |
20130202677 | PATCH - Provided is a patch that ensures high storage stability of donepezil or a salt thereof and allows stable transdermal administration of the donepezil or salt thereof in an amount that provides a pharmaceutical effect. The patch includes a substrate | 08-08-2013 |
20130216603 | PHARMACEUTICAL COMPOSITIONS AND DELIVERY DEVICES COMPRISING STINGING CELLS OR CAPSULES - A pharmaceutical composition is provided. The pharmaceutical composition comprises as an active ingredient a tropane alkaloid drug or a muscarinic receptor antagonist and stinging cells or capsules. | 08-22-2013 |
20130224280 | TRANSDERMAL COMPOSITIONS AND METHODS FOR TREATING STRETCH MARKS - A transdermal delivery device for treating or preventing scars, such as stretch marks, comprising a composition comprising vitamin E, hyaluronan, biotin, | 08-29-2013 |
20130230577 | SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES - The present invention concerns the treatment of serotonergic dysregulation disorders and/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-HTP) therefor. | 09-05-2013 |
20130236528 | ALLERGEN INHIBITOR, ALLERGEN-INHIBITING PRODUCT, ALLERGEN INHIBITING METHOD, AND USE AS ALLERGEN INHIBITOR - The present invention provides an allergen inhibitor which effectively prevents allergens from reacting with specific antibodies, mitigates the allergic symptoms or prevents appearance thereof, and is less likely to cause unpredictable discoloration and discoloration under usual conditions. The allergen inhibitor of the present invention comprises an allergen-inhibiting compound including a linear polymer having at least one of substituents represented by the formulas (1) to (3) at a side chain. Thus, the allergen inhibitor of the present invention shows excellent allergen-inhibiting effects. | 09-12-2013 |
20130243846 | PRESS-CONTACT TYPE IMMERSING INTERLAYER TISSUE - A press-contact type soaked interlayer tissue includes face towel sheets. The face towel sheet comprises two layers of face towel sheet parts ( | 09-19-2013 |
20130251780 | HEMOSTATIC MATERIAL CONTAINING NANO-FIBER CONTAINING SYNTHETIC COLLAGEN - A hemostatic material as a high-performance medical material is described, which is capable of stopping bleeding in short time and is easy to handle and produce. The hemostatic material contains a nano-fiber that contains: a polymer, and a polypeptide having a peptide fragment represented by formula (1): | 09-26-2013 |
20130251781 | Composition and Method for Treating Connective Tissue Damage - The present invention provides a composition, and a method of use thereof, for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues. | 09-26-2013 |
20130259918 | ADHESIVE LABEL WITH BITTERING AGENT AND FLUIDIFYING AGENTS FOR NATURAL AIRWAY SECRETIONS - Label for the outerwear for thinning of airway secretions, containing a bittering agent to reduce the likelihood of accidental ingestion. | 10-03-2013 |
20130259919 | SURGICAL DEVICE FOR SKIN THERAPY OR TESTING - A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft. | 10-03-2013 |
20130259920 | PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE - A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein. | 10-03-2013 |
20130266633 | Transdermal Therapeutic System - The present invention relates to Transdermal Therapeutic Systems having a silicone adhesive layer, to Transdermal Therapeutic Systems providing specific plasma concentrations, to their manufacture and use. | 10-10-2013 |
20130273138 | TRANSDERMAL FORMULATIONS OF GERANYLGERANYLACETONE - Provided herein is a pharmaceutical formulation comprising at least one geranylgeranyl acetone in the form of a transdermal patch. Also provided herein are methods of treating neural diseases or disorders by administering such pharmaceutical formulations. | 10-17-2013 |
20130273139 | TRANSDERMAL DELIVERY SYSTEMS - Disclosed are bupivacaine transdermal delivery systems, and related methods. | 10-17-2013 |
20130273140 | Controlled Release Formulations - The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or controlled release of the incorporated compounds as the hydrogel is degraded in the body. | 10-17-2013 |
20130280318 | Tissue Scaffolds for Controlled Release of Active Agents - Tissue scaffolds of polymer microfiber or nanofiber mesh which release an active agent supportive of alignment, proliferation and matrix deposition of selected musculoskeletal cell over time are provided. Methods for production and use of these tissue scaffolds in treatment of musculoskeletal tissue injuries are also provided. | 10-24-2013 |
20130280319 | Compositions, methods and kits for therapeutic treatment with wet spun microstructures - Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold. | 10-24-2013 |
20130280320 | Method For Producing Articles of Plant Origin Impregnated With a Liquid Plant Substance - The present invention relates to a method for producing articles impregnated with at least one plant substance from at least one plant, characterized in that it comprises the following steps:
| 10-24-2013 |
20130287834 | ANTI-ADHERENT FORMULATION INCLUDING A CATIONIC OR NONIONIC ACRYLATE CO-POLYMER - Liquid formulations having anti-adherent properties are disclosed herein. The liquid anti-adherent formulation described herein acts to prevent the adherence of menses and/or fecal material to the skin in the labial and perianal regions during and after menstruation or defecation, respectively. The liquid anti-adherent formulation contains a carrier, a polymer selected from a nonionic acrylate co-polymer, cationic acrylate co-polymer, and combinations thereof. Anti-adherent formulation is found to be effective if a menses leave-on percentage as defined within the Menses Leave-On Percentage Test method described herein was less than 6.2% after two insults. | 10-31-2013 |
20130287835 | METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS - The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications. | 10-31-2013 |
20130287836 | HIGH STRENGTH CHITIN COMPOSITE MATERIAL AND METHOD OF MAKING - The present invention is directed to a composite laminar material with high mechanical strength and methods of fabricating the material. The invention also provides a method of attaching a medical implant device to tissue. | 10-31-2013 |
20130295158 | COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL - A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl. | 11-07-2013 |
20130309294 | NEW ORAL DISSOLVING FILMS FOR INSULIN ADMINISTRATION, FOR TREATING DIABETES - Provided are orally administrable thin film dosage forms adapted to adhere to a mucosal tissue of a patient, wherein said film comprises mixtures of polymers and insulin. | 11-21-2013 |
20130315975 | USE OF KERATINOCYTES AS A BIOLOGICALLY ACTIVE SUBSTANCE IN THE TREATMENT OF WOUNDS, SUCH AS DIABETIC WOUNDS, OPTIONALLY IN COMBINATION WITH A DPP-4 INHIBITOR - The invention relates to new keratinocytes which may be cultured in vitro and the use thereof for preparing a product which can be used to treat acute and chronic wounds, in combination with a DPP-4 inhibitor. | 11-28-2013 |
20130315976 | PATCH PREPARATION - The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water. | 11-28-2013 |
20130315977 | TRANSDERMAL PATCH - The present invention relates to an external preparation for transdermal administration, which remarkably enhances the skin permeability of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (compound A). The adhesive preparation of the present invention has an adhesive layer formed on one surface of a support, and the adhesive layer contains (i) compound A or a physiologically acceptable acid addition salt thereof, (ii) an adhesive, (iii) lactic acid, and (iv) an additive containing a particular permeation enhancer, whereby remarkably superior skin permeability is provided. | 11-28-2013 |
20130315978 | PATCH AND PATCH PREPARATION - The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug. | 11-28-2013 |
20130323297 | Local administration of gallium compositions to treat pain - Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms. | 12-05-2013 |
20130337031 | TOPICAL FORMULATIONS, SYSTEMS AND METHODS - The present disclosure is drawn to topical formulations, transdermal systems, and related methods. In one embodiment, a topical formulation is provided that includes a local anesthetic, a first compound, and a second compound. The first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate. | 12-19-2013 |
20130337032 | Topical Patch For Pain Relief Using Cooling Agent - Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications. | 12-19-2013 |
20130337033 | NITRIC OXIDE-RELEASING COMPOSITIONS AND METHODS - The invention relates to nitric oxide-releasing compositions comprising polyacrylonitrile polymers that are diazeniumdiolated, and to medical devices comprising such compositions, as well as to methods of making and using the compositions and medical devices. | 12-19-2013 |
20130337034 | BIOFUNCTIONALIZED MAGNETIC NANOWIRES - Magnetic nanowires can be used as an alternative method overcoming the limitations of current cancer treatments that lack specificity and are highly cytotoxic. Nanowires are developed so that they selectively attach to cancer cells via antibodies, potentially destroying them when a magnetic field induces their vibration. This will transmit a mechanical force to the targeted cells, which is expected to induce apoptosis on the cancer cells. | 12-19-2013 |
20130337035 | PLACENTAL TISSUE GRAFTS - A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion. | 12-19-2013 |
20130337036 | METHOD OF USING FIBROUS TISSUE SEALANT - Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds. | 12-19-2013 |
20130344128 | METHOD FOR TREATING OCULAR DEMODEX - The present invention relates to a method for treating a disorder chosen from ocular | 12-26-2013 |
20140017294 | Infused Carbohydrate Based Gel Pad for Sustained Oral Transmucosal Delivery - The present invention provides an infused carbohydrate based gel pad comprising: glucose polymer syrup, sugar, a hydrocolloid gelling agent, salt, acid, water and an infusing compound for oral transmucosal delivery wherein the gel pad (i) provides transmucosal delivery of active ingredients of the infusing compound into the bloodstream over a predetermined period of time; and (ii) possesses the property of adhesion to gum line tissue of an oral cavity and lack of adhesion to buccal tissue of the oral cavity. The present invention further provides a method of making the infused carbohydrate based gel. | 01-16-2014 |
20140017295 | HEMOSTATIC MATERIAL - A medical material having high hemostatic ability, which is easy to handle and shows improved productivity, is described. | 01-16-2014 |
20140017296 | Adhesive Patch - A patch for covering a portion of the anatomical surface of a living being, said patch being able to adhere to the skin or mucosa, and/or a wound, said patch comprising a backing layer and a layer of a skin-friendly adhesive for adhering to the skin or mucosa, wherein said adhesive comprises hydrocolloid particles and zinc sulphate particles, wherein the ratio between the hydrocolloid particles and the zinc sulphate particles is from 4 to 22 w/w. | 01-16-2014 |
20140023695 | PATCH PREPARATION - A patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein the adhesive layer contains 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine or a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid, sesame oil and one or more kinds of stabilizers selected from 2-mercaptobenzimidazole, 2,6-di-tert-butyl-4-methylphenol and propyl gallate. | 01-23-2014 |
20140030314 | TREATMENT OF SKIN DISEASE - The present invention is drawn to compositions, systems, and methods of treating skin disease. In one example, the composition includes a peroxygen, a transition metal or alloy thereof, and optionally, an alcohol and/or a drug. The composition can be packaged as part of a two-part system. | 01-30-2014 |
20140037710 | METHOD FOR PRODUCING PATCH, AND PATCH - A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug:the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15. | 02-06-2014 |
20140050773 | COMPOUND COMPRISING ALPHA-MSH FOR USE IN ENDODONTIC REGENERATION - The present invention concerns a compound comprising an α-MSH peptide, coupled to a polypeptide consisting of a chain of about 15 to about 400 amino acids, for use in endodontic regeneration and/or for the treatment of dental inflammatory diseases. The invention further concerns pharmaceutical compositions, in particular nanostructured compositions, comprising such a compound. | 02-20-2014 |
20140065200 | NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE - In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile. | 03-06-2014 |
20140065201 | COMPOSITE MATERIAL FOR TISSUE REPAIR - The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site. | 03-06-2014 |
20140065202 | COMPOSITE FILM - A composite film comprises a drug sustained-release portion and an adhesive portion which are layered on each other. The drug sustained-release portion has film-like drug layers and a film-like biodegradable polymer layer. The drug sustained-release portion has the drug layer, the biodegradable polymer layer, and the drug layer in this order from the adhesive portion side. Each drug layer is a drug form containing a drug of a predetermined concentration or more. The drug is released from the drug layer exposed. When the drug layer disappears, a biodegradable polymer of the biodegradable polymer layer starts to degrade and/or dissolve. When the biodegradable polymer layer disappears, the drug is released from the drug layer adjoining the adhesive portion. A plurality of pores are formed in the adhesive portion. The pores retain water due to capillary force. | 03-06-2014 |
20140072611 | Methods and Compositions for Treating Post-Cardial Infarction Damage - Compositions for delaying, attenuating or preventing cardiac remodeling following cardiac injury contain fibroblast cells in a dosage providing an effective amount to delay, attenuate or prevent cardiac remodeling following cardiac injury. These cells are obtained by biopsy, preferably from the patient, then cultured and proliferated prior to use. It has been discovered that certain subpopulations of these cells are even better suited for repair or regeneration of tissue, the cells exhibiting properties similar to stem cells or multipotent cells. In a preferred embodiment, the cells are administered to delay, attenuate or prevent cardiac remodeling following cardiac injury. | 03-13-2014 |
20140072612 | ROLLED COLLAGEN CARRIER - The invention relates to a process for the preparation of a rolled compressed collagen carrier and a process for un-rolling said rolled compressed collagen carrier. Said rolled compressed collagen carrier is ready for use in minimally invasive surgery. The invention also relates to a rolled compressed collagen carrier for use in the prevention or treatment of injury associated with performing minimally invasive surgery. | 03-13-2014 |
20140079757 | ORAL DRUG DELIVERY FORMULATIONS - The invention generally relates to the preparation and use of consumable products for delivering a bioactive agent to an oral cavity of a mammal. In certain embodiments, the invention provides a consumable product that releases a bioactive agent within an oral cavity of a mammal, the product including a polymer matrix and one or more bioactive agents, in which the matrix is of a heterogeneous thickness. | 03-20-2014 |
20140079758 | ELECTROSPUN MATERIAL COVERED MEDICAL APPLIANCES AND METHODS OF MANUFACTURE - A medical appliance or prosthesis may comprise one or more layers of electrospun nanofibers, including electrospun polymers. The electrospun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Electrospun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. | 03-20-2014 |
20140079759 | FIBROUS POLYMER SCAFFOLDS HAVING DIAMETRICALLY PATTERNED POLYMER FIBERS - Fibrous polymer scaffolds having at least one layer of diametrically patterned fibers, as well as methods of manufacture, are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Fabrication systems and methods for producing such scaffolds including apparatuses and processes are also provided. | 03-20-2014 |
20140079760 | Phenyl Ester Side Chains to Increase Polymer Resorptivity - The present invention relates to polymers modified to increase their resorbability. In particular, the polymers of the invention have phenyl ester side chains which are good leaving groups and which thereby increase the resorption rate of the polymer relative to the same polymer, for example, bearing a comparable amount of an alkyl ester side chain. Such polymers are generally water insoluble, but when modified are able to solubilize drugs and upon degradation and resorption, release those in a physiological environment in a controlled and/or sustained manner. | 03-20-2014 |
20140120151 | Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use - The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof. | 05-01-2014 |
20140120152 | Scaffold Delivery of Immune Suppressors and Transplant Material for Control of Transplant Rejection - The present invention provides compositions, devices, and methods for the coordinated delivery of transplant material and immune suppressors for control of transplant rejection. In particular embodiments, immune suppression cells (e.g., regulatory T cells) and transplant material (e.g., cells, tissue, etc.) are provided within a delivery scaffold for transplant into a subject. | 05-01-2014 |
20140127281 | PROPYNYLAMINOINDAN TRANSDERMAL COMPOSITIONS - Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix which includes the propynylaminoindan, a pressure sensitive adhesive that includes an acrylate copolymer and a cationic acrylic copolymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions. | 05-08-2014 |
20140127282 | Membrane - The invention relates to a membrane for supporting cells, especially retinal pigmented epithelial (RPE) cells. The membrane is useful in the treatment of conditions such as age related macular degeneration. The membrane may also be used to support retinal pigmented epithelial cell precursors and retinal cell derivative cells formed from the differentiation of RPE on the membrane. | 05-08-2014 |
20140141056 | LIDOCAINE-CONTAINING HYDROGEL PATCH - A lidocaine-containing hydrogel patch comprising:
| 05-22-2014 |
20140147489 | RAPIDLY DISSOLVING FILM FOR DELIVERY OF AN ACTIVE AGENT - A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent. | 05-29-2014 |
20140161865 | PATCH AND METHOD FOR PRODUCING THE SAME - A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form. | 06-12-2014 |
20140161866 | STRUCTURES AND METHODS FOR DELIVERING TOPICAL COMPOSITIONS - A system for topically administering a chemical agent to a human body. The chemical agent may be mixed with a carrier and the form a tangible application device. The carrier may be compound or a physical structure such as an absorbent material. | 06-12-2014 |
20140161867 | METHOD OF TOPICALLY APPLYING GLYCOPYRROLATE SOLUTION USING ABSORBENT PAD TO REDUCE SWEATING - This invention relates to a convenient and safe product and method of applying glycopyrrolate topically in order to reduce excessive sweating in localized areas for those who suffer from this condition. This invention also relates to combining oral and topical delivery of glycopyrrolate to reduce excessive sweating and minimize side effects. This invention also relates to a convenient and safe product and method of applying glycopyrrolate topically to areas of compensatory sweating after endoscopic thoracic sympathectomy. | 06-12-2014 |
20140161868 | TRANSDERMAL DELIVERY SYSTEM KIT - A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin. | 06-12-2014 |
20140170204 | Multilayer Thin Film Drug Delivery Device and Methods of Making and Using the Same - Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject. | 06-19-2014 |
20140170205 | ROPINIROLE-CONTAINING PATCH AND PACKAGE THEREOF - A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer satisfies the following two conditions:
| 06-19-2014 |
20140170206 | COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL - A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl. | 06-19-2014 |
20140178457 | BINDER AND PROCESS FOR PRODUCING FABRICS CONTAINING CYCLODEXTRINS FIXED BY SAID BINDER - The application concerns a Binder (comprising sulfamic acid, ammonium sulfamate and ammonium sulfate) and process of production of fabrics containing cyclodextrins fixed to the binder. The technology allows fixing a binder to natural, synthetic or artificial fibers, and, by means of a thermal processes, to fix cyclodextrins to the same binder, giving rise to fabrics suitable to incorporate active principles and to release them along with time. Peculiar characteristics of the binder are its abilities to interact with several types of fabric, independently of their composition, and with several types of cyclodextrin. Other peculiarities of embodiments are: the ability to produce functionalized fabrics, adapted to be weighted with desired molecules and release them gradually along time, with a process that does not alter the original characteristics of the fabric; the possibility of repeating several times the weighting of such molecules, so as to be able to define such fabrics as “reloadable” or “rechargeable.” | 06-26-2014 |
20140178458 | MEDICINAL SKIN PROTECTION COMPOSITION WITH AN ACTIVE INGREDIENT COMBINATION WHICH IMPROVES THE SKIN BARRIER - A medicinal skin protection composition is disclosed with an active ingredient combination that specifically serves to care for aging skin that is exposed to difficult environmental conditions. The active ingredient combination obligatorily includes the components almond oil, linseed oil fatty acids, amino acids, and creatine. The medicinal skin protection composition can be used for aging skin in the form of creams, lotions etc., and also for a variety of incontinence articles, such as sanitary towels or nappies. | 06-26-2014 |
20140186421 | EXTENDED BUPRENORPHINE TRANSDERMAL DELIVERY COMPOSITIONS AND METHODS FOR USING THE SAME - Aspects of the invention include extended transdermal delivery devices for delivering buprenorphine to a subject for an extended period of time, where the transdermal delivery devices include buprenorphine, an α-hydroxy acid and a pressure sensitive adhesive. In certain instances, buprenorphine, α-hydroxy acid and the pressure sensitive adhesive are provided as a single matrix layer formulation. Also provided are methods of using the subject extended transdermal delivery devices, as well as kits containing the extended transdermal delivery device. | 07-03-2014 |
20140186422 | PROPYNYLAMINOINDAN TRANSDERMAL COMPOSITIONS - Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix which includes the propynylaminoindan, a pressure sensitive adhesive that includes an acrylate copolymer and a cationic acrylic copolymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions. | 07-03-2014 |
20140186423 | Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease - The present invention relates to a method and device for treating patients with a Protein Misfolding Disease by chronically administering an effective dose of a thrombolytic reagent and/or a thrombolytic reagent regulator over an intermittent period of time. The thrombolytic reagents degrade the misfolded proteins that accumulate and that can become toxic in such patients. The thrombolytic reagent regulators increase the catalytic efficiency of the thrombolytic reagents to reduce the amount of thrombolytic reagents necessary for an effective dose. The administration is administered transdermally via a transdermal patch that is equipped with an ultrasound transducer for enhancing the penetration of the thrombolytic reagent and thrombolytic reagent regulator into the bloodstream of a patient by increasing the permeability of the patient's skin. | 07-03-2014 |
20140186424 | MULTI-POLYMER COMPOSITIONS FOR TRANSDERMAL DRUG DELIVERY - Multi-polymer compositions for the transdermal delivery of drugs, such as amine-functional drugs, in a flexible, finite form are described. The compositions comprise a polymer matrix that includes a drug or a pharmaceutically acceptable salt thereof and a polymer matrix comprising acrylic polymer(s), polyisobutylene polymer(s) and styrene-isoprene-styrene block copolymer(s). Methods of manufacturing and methods of using the compositions also are described. | 07-03-2014 |
20140186425 | LAYERED ADHESIVE CONSTRUCT - A layered adhesive construct includes a backing layer and a layer of a pressure sensitive, hot melt processable adhesive composition. The adhesive composition includes a polar plasticising oil or a combination of polar plasticising oils in a content above 10% (w/w), and 10-50% (w/w) of a polar polyethylene copolymer. The polyethylene copolymer has a melt flow index below 2 g/10 min (190° C./21.1N), and the polar plasticising oil is a liquid rosin derivative, animal oils and derivatives, esters, ethers, glycols, poly propylene oxide, or alpha-butoxy-polyoxypropylene. | 07-03-2014 |
20140186426 | CATALYTIC DELIVERY NANOSUBSTRATES (CDNS) FOR HIGHLY EFFICIENT DELIVERY OF BIOMOLECULES - This invention relates, e.g., to a molecular delivery system comprising A. a substrate having a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the substrate, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises, encapsulated therein, a molecule of interest, and on its surface, multiple copies of second member of the binding pair. Methods of using the molecular delivery system to deliver a molecule of interest to a cell are also described. | 07-03-2014 |
20140186427 | ORODISPERSIBLE FILMS FOR THE MANUFACTURING OF INDIVIDUALISED MEDICINE OR FOR LARGE SCALE PRODUCTION - The present invention pertains to oral applicable therapeutic dosage forms, in particular to orodispersible films. The present invention especially is directed to orodispersible films comprising a base layer substantially free of therapeutically active agents and a top layer comprising the desired therapeutically active agents. The present invention also concerns suitable base layers for such orodispersible films as well as therapeutical uses thereof and methods for manufacturing them. | 07-03-2014 |
20140193477 | COLLAGEN BASED MATERIALS AND USES RELATED THERETO - This disclosure relates to materials fabricated from collagen and uses relates thereto. Typically, layers of collagen are stretched during a curing period and optionally coated or impregnated with an elastin like protein. In certain embodiments, these materials can be used in tissue repair or arranged into cylinders and utilized as a prosthetic vascular graft. | 07-10-2014 |
20140199367 | Topical Transdermal Method for Delivering Nutrients Through the Skin for Expeditied Wound Healing and Skin Rejuvenation - The present invention relates to liquid application for skin rejuvenation created from specific amino acids, lipids, nucleic acids and vitamins. This collection of molecules delivers precisely the factors necessary to a specific site requiring healing; a direct intervention system to most expeditiously remodel skin with building blocks. This delivery is a transdermal topical delivery and healing is via specific molecules that engender a false autocoid reaction rapidly followed by an incremental healing-anti-inflammatory response augmented by very specific GRAS ingredients in the invention and also recruited from the body to this needy site. Energy is brought to site by transdermally delivered protons and enhanced by the local vascular flow initiated by transdermal molecules. | 07-17-2014 |
20140205651 | HYGIENE TISSUE - A hygiene tissue includes a composition including one or more lactic acid producing bacterial strains and a lipid phase including at least one lipid, wherein the lipid is selected from the group having olive oil, canola oil, coconut oil, palm kernel oil, peanut oil, soy bean oil, Dimethicone, paraffin oil, and petrolatum; and a matrix impregnated by the composition. | 07-24-2014 |
20140212471 | BONE FIBER COMPOSITIONS - An osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is provided. The mixture is visible under X ray and remodels more easily than comparable mixtures of demineralized bone matrix and surface demineralized cortical bone chips. The osteoinductive implantable compositions comprises demineralized bone fibers in an amount from about 30 vol % to about 45 vol % and mineralized bone fibers in an amount from about 55 vol % to about 70 vol %. The osteoinductive implantable compositions can be delivered in delivery systems including mesh coverings for administration at surgical sites. A method of treating a bone defect caused by injury, disease, wounds, or surgery utilizing the osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is also provided. | 07-31-2014 |
20140220099 | BIODEGRADABLE POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY - The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9 m+p+q=1 whereby m or p could be 0 n is about 5 to about 300; (pref. 50-200) R | 08-07-2014 |
20140220100 | VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION - The invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity comprising (i) HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter. | 08-07-2014 |
20140220101 | SUBSTANTIALLY DRY NICOTINAMIDE PADS FOR TREATMENT OF SKIN INFLAMMATION - A substantially dry nonwoven pad is provided containing a formulation comprising nicotinamide in an amount between about 1% to about 10% w/w based on the total weight of the formulation and at least one water-soluble gritty polymer in an amount between about 10% to about 75% w/w based on the total weight of the formulation. The nicotinamide-containing pad is used topically for treatment of skin inflammation, in one easy step. In a method for treating skin inflammation, including acne, rosacea, and acne scars (hyperpigmentation), the nicotinamide-containing pad is moistened, then applied to the skin treatment area using gentle scrubbing, followed by rapid absorption of the formulation by the skin, and rinsing the skin with water. | 08-07-2014 |
20140220102 | ECTOCORNEA-LIKE SHEET AND METHOD OF CONSTRUCTING THE SAME - It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained. | 08-07-2014 |
20140234393 | ADHESIVE PATCH - Provided is an adhesive patch which has excellent rivastigmine storage stability and an increased skin permeability of rivastigmine to such an extent that the amount of percutaneous absorption required for treating Alzheimer's disease is obtained. | 08-21-2014 |
20140242145 | CHITOSAN NANOFIBER FOR ANIONIC PROTEIN DRUG DELIVERY, METHOD OF PREPARING THE SAME, AND PHARMACEUTICAL PREPARATION FOR TRANSMUCOSAL ADMINISTRATION COMPRISING THE CHITOSAN NANOFIBER - A chitosan nanofiber for delivering an anionic protein drug, a method of preparing the same, and a pharmaceutical preparation for transmucosal administration including the chitosan nanofiber are provided. The chitosan nanofiber including an anionic protein drug in a core and chitosan in a shell is prepared by coaxial electrospinning an aqueous solution of the anionic protein drug through an inner nozzle and a solution of the chitosan or a chitosan derivative through an outer nozzle. | 08-28-2014 |
20140242146 | FILAMENT BASED ON HYALURONIC ACID IN THE FORM OF FREE ACID AND METHOD FOR OBTAINING IT - The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions. | 08-28-2014 |
20140242147 | ADSORBENTS FOR ORAL ADMINISTRATION - The present invention aims to provide an adsorbent for oral administration comprising ACF that has high adsorption or removal performance by adsorbing or removing toxic substances in the living body greatly and rapidly. The present invention is an adsorbent for oral administration comprising activated carbon fibers for treating or preventing kidney diseases or dialysis complications. | 08-28-2014 |
20140248330 | DEVICE FOR TRANSDERMAL ADMINISTRATION OF DRUGS INCLUDING ACRYLIC POLYMERS - A transdermal delivery system is provided where the drug delivery rates, onset and profiles of at least one active agent are controlled by selectively manipulating the monomeric make up of an acrylic-based polymer in the transdermal drug delivery system. The drug carrier composition may be comprised of (a) one or more acrylic-based polymers having one or more different monomers selected from the group consisting of hard and soft monomers; (b) one or more silicone-based polymers; and (c) one or more active agents where the device provides a desired solubility for the active agent and controls drug delivery rates, onset and profiles of at least one active agent. | 09-04-2014 |
20140248331 | Polyhydroxyalkanoate Medical Textiles and Fibers - Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties. | 09-04-2014 |
20140255464 | MULTI-LAYER BIODEGRADABLE DEVICE HAVING ADJUSTABLE DRUG RELEASE PROFILE - Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents. | 09-11-2014 |
20140271784 | DECELLULARIZED OMENTUM MATRIX AND USES THEREOF - Methods for defatting omentum and processes for preparing an acellular omentum, i.e., devitalized or decellularized omentum, comprising extracellular matrix for implantation into a mammalian system. Constructs for medical applications comprising decellularized omentum are also described. More specifically, mesh reinforced omentum biomatrix for soft tissue repair is described. | 09-18-2014 |
20140271785 | BIOACTIVE POROUS BONE GRAFT IMPLANTS - Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling. | 09-18-2014 |
20140271786 | BIOACTIVE POROUS BONE GRAFT COMPOSITIONS IN SYNTHETIC CONTAINMENT - Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling. | 09-18-2014 |
20140271787 | CONTINUOUS SINGLE LAYER FILM STRUCTURE INCLUDING DISCRETE DOMAINS - Disclosed herein is a soft, flexible, continuous, single-layer structural directional active delivery device such as a film product with discrete domains useful for controlled administration of the active to a patient. The discrete domains are substantially inseparable from one another, have different rates of dissolution and advantageously offer superior adhesion to the body of the patient while administering the active directionally and effectively. | 09-18-2014 |
20140271788 | SUBLINGUAL AND BUCCAL FILM COMPOSITIONS - The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent. | 09-18-2014 |
20140271789 | SUBLINGUAL AND BUCCAL FILM COMPOSITIONS - The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent. | 09-18-2014 |
20140271790 | FASCIA FIBROUS COMPOSITIONS AND METHODS FOR THEIR USE AND MANUFACTURE - Embodiments of the present invention encompass fascia, fat, and dermis fibrous compositions, and methods for their manufacture and use. In a first aspect, embodiments of the present invention encompass methods for obtaining a fascia fiber for use in producing a biotextile. Exemplary methods may include treating a cadaveric fascia tissue with acetone, and obtaining the fascia fibers from the treated fascia tissue. In some cases, methods may include processing the fascia fibers to produce the fibrous fascia biotextile. | 09-18-2014 |
20140271791 | ORAL ENERGY PRODUCTS INCLUDING ENCAPSULATED CAFFEINE - A composition for human consumption includes a base composition having a pH of about 2 to about 5 and encapsulated caffeine dispersed throughout at least a portion of the base composition. The encapsulated caffeine can be a caffeine complex. The base composition can include a liquid or a food. An oral pouch product includes a porous pouch wrapper, an inner botanical filling material contained within the pouch wrapper, and encapsulated caffeine dispersed throughout at least a portion of the oral pouch product. The encapsulated caffeine is included in the composition and/or the oral pouch product an amount sufficient to release about 50 mg to about 200 mg of caffeine. The composition can provide immediate release of caffeine and/or release of caffeine over an extended period of time. | 09-18-2014 |
20140271792 | METHYLPHENIDATE TRANSDERMAL COMPOSITIONS WITH RUBBER-BASED ADHESIVES - Transdermal compositions comprising methylphenidate in a polymer matrix comprising a rubber-based pressure-sensitive adhesive are disclosed, such as a polymer matrix comprising styrene-isoprene-styrene or polyisobutylene polymers. Method of making such compositions, and therapeutic methods using them also are disclosed. | 09-18-2014 |
20140271793 | THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS - The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits. | 09-18-2014 |
20140271794 | ANTIMICROBIAL FOAM MEDICAL PATCH AND METHOD OF MAKING THE SAME - A foam medical patch is provided including a foam substrate having integrated therein an antimicrobial material comprising a silane quaternary ammonium salt. The antimicrobial material is substantially free from arsenic, silver, tin, heavy metals and polychlorinated phenols. The silane quaternary ammonium salt includes 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. | 09-18-2014 |
20140271795 | NANOFIBROUS MATERIALS AS DRUG, PROTEIN, OR GENETIC RELEASE VEHICLES - The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment. | 09-18-2014 |
20140271796 | OXYBUTYNIN-CONTAINING TRANSDERMAL ABSORPTION PREPARATION - A transdermal absorption preparation containing at least one drug selected from oxybutynin and pharmaceutically acceptable salts thereof and 0.05% by mass or more of a sterol selected from cholesterols, cholesterol derivatives and cholesterol analogs, relative to a total amount of the transdermal absorption preparation. | 09-18-2014 |
20140287020 | SURGICAL DEVICE FOR SKIN THERAPY OR TESTING - A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft. | 09-25-2014 |
20140294917 | THERMOSET AND THERMOPLASTIC FIBERS AND PREPARATION THEREOF BY UV CURING - In one embodiment, this invention is directed to a method of preparing a thermoset or thermoplastic polymer fiber comprising the following sequential steps: (i) providing a monomeric or oligomeric mixture, wherein said monomeric or oligomeric mixture comprises monomers or oligomers which polymerize by radiation; (ii) optionally heating or cooling said monomeric or oligomeric mixture for obtaining optimal viscosity; (iii) pumping said monomeric or oligomeric mixture through a spinneret, die or any other nozzle type; and (iv) radiating said monomeric or oligomeric mixture with a radiation source under room temperature, wherein said thermoset or thermoplastic polymer fibers are formed. | 10-02-2014 |
20140302116 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes a substrate; and a multilayer film coated on the substrate, wherein adjacent layers of the multilayer film are associated with one another via one or more non-covalent interactions, wherein the multilayer film comprises a first nucleic acid agent present at a loading density, and further wherein the multilayer film is characterized in that, when the structure is placed on a subject so that the multilayer film contacts cells, the first nucleic acid agent is released with a profile characterized by a feature selected from the group consisting of 1) being a burst-free release; 2) being a sustained release; and 3) exhibiting in vitro and/or in vivo biological effectiveness. | 10-09-2014 |
20140302117 | TISSUE PRODUCTS INCLUDING A TEMPERATURE CHANGE COMPOSITION CONTAINING PHASE CHANGE COMPONENTS WITHIN A NON-INTERFERING MOLECULAR SCAFFOLD - Wiping products, such as facial tissues, contain a temperature change composition that can provide a cooling sensation when contacted with the skin of a user. The temperature change composition includes a phase change material and a non-interfering molecular scaffold. The phase change materials, in one embodiment, can have a relatively high heat of fusion. When undergoing a phase change, the temperature change composition absorbs heat and thereby provides a cooling feeling or cooling sensation to the skin of a user. | 10-09-2014 |
20140308335 | TRANSDERMAL PREPARATION - The present invention provides transdermal absorption preparation having a support, and a drug-containing adhesive layer formed on the support, wherein a drug-containing adhesive layer contains donepezil or a salt thereof, and a higher fatty acid salt. | 10-16-2014 |
20140314828 | MOISTURE-ABSORBING AND DEODORIZING FIBER, METHOD FOR MANUFACTURING THE SAME, AND FIBER STRUCTURE CONTAINING THE SAME - In the prior art, there has not been provided a fiber that can quickly and persistently deodorize and absorb the smell and the damp feeling due to body fluid generated from the body. The present invention provides a fiber having such property, and specifically provides a moisture-absorbing and deodorizing fiber, characterized in that, a basic polymer is ionically-bonded in an amount of 0.2 to 4 mmol/g as an amount of amino group onto the surface of a moisture-absorbing fiber having a crosslinked structure and also having 3 to 8 mmol/g of carboxyl group. | 10-23-2014 |
20140314829 | PERACID-GENERATING COMPOSITIONS - Described herein are tooth whitening strips comprising an hydratable adhesive film having a granular bleaching ingredient attached thereto, wherein upon hydration, the granular bleaching ingredient releases hydrogen peroxide which is used by an enzyme catalyst having perhydrolytic activity to enzymatically produce an effective amount of peracid bleaching agent from an acyl donor substrate. Methods of making and use the tooth whitening strips are also provided. | 10-23-2014 |
20140322299 | Controlled Release of Active Using pH - Dissolvable polymeric compositions are described which when exposed to certain pH conditions, controllably release one or more actives. The active agents can be nearly any active agent such as chlorhexidine gluconate (CHG). Also described are products using such compositions such as dressings. In addition, methods of controllably releasing one or more actives are described. | 10-30-2014 |
20140335148 | BIOACTIVE SUBSTANCE-CONTAINING NANOFIBERS AND USES THEREOF - An ultrafine fiber comprises a ceramic-based fibrous body and a biologically active substance encapsulated in the body, substantially encapsulated in the body, or surface-attached to the body. In an example, an ultrafine fiber comprises a core comprising a biologically active substance and a ceramic-based shell surrounding or substantially surrounding the core. | 11-13-2014 |
20140348898 | LOCAL ADMINISTRATION OF GALLIUM COMPOSITIONS TO TREAT PAIN - Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms. | 11-27-2014 |
20140356411 | PLASMONIC-MAGNETIC BIFUNCTIONAL NANOTUBES FOR BIOLOGICAL APPLICATIONS - The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated. | 12-04-2014 |
20140363483 | PHARMACEUTICAL USE OF A COMPOSITION INCLUDING A CARBONACEOUS MATERIAL AND AN ACTIVE PARTICLE - A method of treating or preventing | 12-11-2014 |
20140363484 | FIBROUS BIO-DEGRADABLE POLYMERIC WAFERS SYSTEM FOR THE LOCAL DELIVERY OF THERAPEUTIC AGENTS IN COMBINATIONS - The present invention is related to flexible, fibrous, biocompatible and biodegradable polymeric wafer; consists of more than one polymeric fibers, each one loaded with different therapeutic agents having mutually exclusive synergistic activity. The wafer is capable of delivering the drugs locally in to the diseased site like tumor, inflammation, wound, etc., in a controlled and sustained fashion for enhanced therapeutic effect. The combination of drugs loaded in the wafer is chosen in such a way that the second or consecutive drugs will enhance or improve the therapeutic effect of the first drug. | 12-11-2014 |
20140363485 | WIPE AND METHODS FOR IMPROVING SKIN HEALTH - The present invention relates to methods and products, such as wet wipes and absorbent articles, that are capable of imparting a health benefit when used in the intended fashion. More specifically, the products described herein comprise one or more botanical compounds, which are capable of selectively controlling the balance of flora on the skin. The compounds may enhance the adherence of healthy flora to the surface of skin or mucosa, inhibit the growth of problem flora on or around the skin surface, or inhibit the adherence of problem flora to the surface of skin or mucosa, or any combination thereof. | 12-11-2014 |
20140370074 | ADHERING COMPOSITION AND METHODS OF APPLYING THE SAME - A method of in-situ adhering comprising providing pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; spreading a layer of the pre-gel onto a first surface; adding a solid support, comprising at least one cross linking agent capable of interacting with the water miscible polymer to the pre-gel; and allowing the pre-gel to cure and adhere onto the first surface. | 12-18-2014 |
20140377328 | INTRAORAL SOLUBLE-TYPE FILM PREPARATION - Provided is an intraoral soluble-type film preparation in which an unpleasant taste of a drug is masked. The intraoral soluble-type film preparation comprises a drug layer containing: a drug having a bitter taste and/or an astringent taste; an alkyl sulfate at a content of ¾ mol or more with respect to 1 mol of the drug; and a water-soluble polymer. | 12-25-2014 |
20140377329 | SUBLINGUAL FILMS - The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith. | 12-25-2014 |
20140377330 | Bioactive Hydrogel - The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds. | 12-25-2014 |
20150017224 | METHOD FOR PRODUCING A TISSUE PAPER SHEET MATERIAL CONTAINING AN ADJUVANT SUBSTANCE FOR THE TREATMENT OF ALLERGIC RHINITIS, AND THE PRODUCT OBTAINED - The following steps are provided for producing a sheet cellulose material, for instance a handkerchief, comprising at least one adjuvant substance for the treatment of allergic rhinitis:
| 01-15-2015 |
20150024028 | TRANSDERMAL THERAPEUTIC SYSTEM HAVING IMPROVED LONG-TERM WEARING COMFORT - The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. | 01-22-2015 |
20150030661 | Multilayer Films and Uses Thereof - The invention provides, inter alia, multilayer films of alternating layers of a glycosylated polymer (e.g. a mucin) and a lectin, as well as methods of making and using these films. The films can be adapted for, inter alia, delivery of a biologically active agent providing a non-toxic substrate to support cell growth, replication, and/or maintenance as well as detecting a microorganism and/or reducing microorganism adherence to a surface. | 01-29-2015 |
20150030662 | Generation of Brown Adipose Tissue (BAT) from Mesenchymal Cells - Methods of generating functional human brown adipocytes, comprising exposing human stem cells, progenitor cells, or white adipocytes to culture with an differentiation cocktail that comprises one or more browning agents (e.g., one or more macromolecular crowders), and optionally one or more adipogenic agents, are described, as are populations of human brown adipocytes generated by the methods, and uses for the populations. Methods of generating functional human brown adipocytes in an individual, such as by administering a pharmaceutical composition comprising an differentiation cocktail, are also described. | 01-29-2015 |
20150037390 | SELF-ASSEMBLING BIS-UREA COMPOUNDS FOR DRUG DELIVERY - Cationic, anionic, and/or zwitterionic bis-urea compounds self-assemble by non-covalent interactions in aqueous solution to form high aspect ratio nanofibers. The nanofibers reversibly bind drugs by non-covalent interactions, forming drug compositions for exhibiting sustained release of the drug. | 02-05-2015 |
20150037391 | Local administration of gallium compositions to treat pain - Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms. | 02-05-2015 |
20150064231 | Oral film containing opiate enteric-release beads - A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines. | 03-05-2015 |
20150086608 | MATRIX AND DEVICE AND USE THEREOF FOR OPTICALLY-CONTROLLED RELEASE OF CHEMICALS - A porous polymeric matrix and a device for optically-controlled release of chemicals allow a controlled and localized administration of a chemical species, by exploiting the thermosensitivity of amphiphilic supramolecular structures used as reservoir without this requesting a direct heating, at the same time by guaranteeing a precise dosage and positioning of the release of the chemical species. | 03-26-2015 |
20150086609 | ADHESIVE LABEL WITH BITTERING AGENT AND FLUIDIFYING AGENTS FOR NATURAL AIRWAY SECRETTIONS - Label for the outerwear for thinning of airway secretions, containing a bittering agent to reduce the likelihood of accidental ingestion. | 03-26-2015 |
20150098979 | METHOD FOR IMPARTING ENDURING BENEFICIAL FEATURES TO FLOCKED SURFACES - A method of imparting enduring beneficial features to a hard flocked surface of an article is provided. The method includes encapsulating a desired beneficial agent as a core material in a polymeric microcapsule, and transferring polymeric microcapsule to the surface by a dipping, spraying, or padding application. The beneficial agent, after getting transferred to the surface of a hard flocked article, imparts long lasting performance, provides fragrance and may protect an article from odor, insect, pest, fungi, bacteria, viruses, and the like. The polymeric microcapsules deliver long lasting benefits to surfaces with flocking, such as clothes hangers. Also described is a process for manufacture of flocked items with benefit delivering polymer microcapsules, without the need for binders or adhesives. Benefit agents are released with shear force on the flocked surface, so they are released when used and provide long-lasting performance. | 04-09-2015 |
20150098980 | Dexmedetomidine Transdermal Delivery Devices and Methods for Using the Same - Aspects of the invention include transdermal delivery devices for delivering dexmedetomine to a subject, where the transdermal delivery devices include a single layer matrix dexmedetomine composition. Transdermal delivery devices according to certain embodiments include dexmedetomidine and a pressure sensitive adhesive provided as a single layer formulation. Also provide are methods of using the subject transdermal delivery devices to deliver dexmedetomidine to a subject, as well as kits containing the transdermal delivery devices. | 04-09-2015 |
20150098981 | Methods and Compositions for Transdermal Delivery of a Non-Sedative Amount of Dexmedetomidine - Aspects of the invention include methods for applying to a subject a transdermal delivery device configured to deliver a non-sedative amount of a dexmedetomidine composition. In practicing methods according to certain embodiments, a non-sedative amount of a dexmedetomidine composition is transdermally applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to a subject. Also provided are transdermal delivery devices having a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices. | 04-09-2015 |
20150098982 | Methods and Compositions for Managing Pain Comprising Dexmedetomidine Transdermal Compositions - Aspects of the invention include methods of managing pain in a subject by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a pain relieving effective amount of dexmedetomidine to a subject experiencing pain. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver an amount of dexmedetomidine effective to manage pain in the subject. Also provided are transdermal delivery devices configured to deliver dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices. | 04-09-2015 |
20150098983 | Methods and Compositions for Treating Withdrawal Syndromes Using Non-Sedative Dexmedetomidine Transdermal Compositions - Aspects of the invention include methods of treating withdrawal syndrome by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a non-sedative amount of dexmedetomidine to a subject diagnosed as having withdrawal syndrome. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to treat withdrawal syndrome in the subject. Also provided are transdermal delivery devices configured to deliver a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices. | 04-09-2015 |
20150098984 | NANOLITHOGRAPHY USING LIGHT SCATTERING FROM PARTICLES AND ITS APPLICATIONS IN CONTROLLED MATERIAL RELEASE - The present disclosure provides hollow nanostructures, methods of forming thereof, and methods of delivery of further nanomaterials utilizing the hollow nanostructures. The hollow nanostructures can be formed by illuminating particles, such as spherical particles, to create a scattering pattern that can be captured on, for example, a photoresist. Thus formed nanoparticles can have a substantially frusto-conical shape that can be tailored based on a variety of factors, including, for example, particle size, particle shape, light exposure characteristics, and light polarization. | 04-09-2015 |
20150104494 | METHODS FOR REPAIR OF EAR CANAL TISSUE DEFECTS - Disclosed herein are methods of repairing ear canal tissue defects by administering non-basic fibroblast growth factor (FGF) to the ear canal tissue defect. Also disclosed are delivery devices to administer said non-basic FGF. | 04-16-2015 |
20150118281 | Compositions and Methods For Modulation of Vascular Structure and/or Function - The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a β-1-4 conformation. | 04-30-2015 |
20150118282 | TRANSDERMALLY ABSORBABLE PREPARATION CONTAINING ROTIGOTINE - A method for preventing the precipitation of rotigotine crystals, including a step of mixing rotigotine and one or more crystallization prevention agents selected from the group consisting of fatty alcohols, fatty acids, fatty acid esters, fatty acid amides, and the derivatives thereof, and to a transdermally absorbable preparation that includes rotigotine and crystallization prevention agents. | 04-30-2015 |
20150125510 | DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF - A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby. | 05-07-2015 |
20150125511 | STERILE COMPOSITION - A sterile composition which comprises a protein and an aliphatic polyester containing the protein and is sterilized with radiation. In this sterile composition, the structure and function (activity) of the protein are retained. | 05-07-2015 |
20150132360 | MULTI-LAYERED ANTI-ADHESION DEVICE - Compositions and methods are provided for preparing an adhesion barrier in the form of a foldable or flexible biodegradable polymer matrix that effectively reduces, prevents or treats adhesions in a patient in need thereof. In one embodiment, the matrix comprises a first porous layer comprising collagen and a second porous layer comprising collagen and dextran, wherein the dextran is loaded in the second layer in an amount of from about 5% to about 90% by weight based on a total weight of the matrix. In some embodiments, the matrix prevents or reduces cell growth into the matrix so as to reduce or prevent adhesions. In some embodiments, the matrix is in a sheet or strip form that can be folded into a tube form. | 05-14-2015 |
20150132361 | HEMOSTATIC PRODUCTS - A method of inducing hemostasis in a wound. A hemostatic product is applied to a wound. The hemostatic product includes at least one hemostasis component. The hemostatic product is retained with respect to the wound by positioning a hydrogel material at least partially over the hemostatic product. At least a portion of the hemostatic product is dissolved. Hemostasis is induced in the wound with the at least one hemostasis component. The hydrogel material is separated from the wound. Substantially all of the hemostatic product remains on the wound. | 05-14-2015 |
20150140063 | HYDROPHOBIC CERAGENIN COMPOUNDS AND DEVICES INCORPORATING SAME - A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a C Log P value of at least 6.0, 6.25, 6.5, 7.5, 8.5, or 10. | 05-21-2015 |
20150140064 | NANOSCALE COLLAGEN PARTICLES AND MEMBRANES - Nano scale collagen particles can be obtained from an embrittling and attrition process that reduces the size of collagen particles to the nano scale. These nano scale collagen particles have many favorable properties such as providing beneficial and enhanced properties for cell seeding and wound healing. The nano scale collagen particles can be included in biocompatible (e.g., biostable or biodegradable) compositions and are useful for wound treatment and management, as well as in cell cultures and tissue engineering implants. | 05-21-2015 |
20150147380 | COCHLEATES MADE WITH SOY PHOSPHATIDYLSERINE - Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B. | 05-28-2015 |
20150147381 | HOMEOPATHIC THERAPEUTIC METHOD AND COMPOSITIONS - The present invention relates to compositions including a homeopathic aqueous substance active (HASA) and at least one hydrophilic gelling agent, the HASA comprises a homeopathic compound at a potency of 30C or higher and an uninhibited aqueous composition. The present invention also relates to methods of preparing a hydrophilic HASA-gel matrix. The method includes combining a homeopathic compound and an uninhibited aqueous composition to produce a HASA; combining the HASA with at least one hydrophilic gelling agent; and thereafter, forming the hydrophilic HASA-gel matrix by use of at least one of a thickening agent, a crosslinking agent, or a polymerization agent. | 05-28-2015 |
20150290248 | FIBROUS COMPONENT FOR HEALTH, PERFORMANCE, AND AESTHETIC TREATMENT - Described herein are methods for initiating or enhancing tissue generation and tissue regeneration in a subject. The method generally involves applying at a desired site in the subject by a non-surgical technique a composition composed of a fibrous component, wherein the fibrous component comprises fibers having a diameter between 100 nm and 10 μm. The fibrous component can be used alone or in combination with one or more additional agents depending upon the application. The methods described herein have numerous applications in the medical and cosmetic surgery industry. | 10-15-2015 |
20150306028 | LAMINATED FILM AND METHOD FOR LAMINATING FILMS - The inventive concept relates to a laminated film and a method of laminating films, and the disclosed laminated film includes at least two films sequentially stacked and bonded to each other, wherein each of the films may be each independently a gastric film or an enteric film. | 10-29-2015 |
20150306093 | TRANSDERMAL DELIVERY SYSTEM - The invention relates to a method of treating pain in a patient by applying a transdermal therapeutic system for the transdermal administration of buprenorphine for 7 days on the skin of a patient, said transdermal therapeutic system comprising a buprenorphine-containing self-adhesive layer structure comprising A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing matrix layer on said buprenorphine-impermeable backing layer, the matrix layer comprising a) a polymer base, b) buprenorphine, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the polymer base, and C) a skin contact layer on said buprenorphine-containing matrix layer comprising a polymer-based pressure-sensitive adhesive, and optionally wherein the buprenorphine-containing self-adhesive layer structure contains said buprenorphine in an amount of less than 0.8 mg/cm2 buprenorphine base or an equimolar amount of a pharmaceutically acceptable salt thereof. | 10-29-2015 |
20150306227 | POLYMERS INCLUDING ACTIVE AGENTS - Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members. | 10-29-2015 |
20150306277 | BIODEGRADABLE TISSUE COMPOSITION WITH BIODEGRADABLE CROSS-LINKERS - Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed. | 10-29-2015 |
20150313236 | SYNERGISTIC COMBINATION OF A LENACIL AND IPBC FOR DRY FILM PROTECTION - A synergistic antimicrobial composition containing lenacil and 3-iodine-2-propenyl-butylcarbamate is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition. | 11-05-2015 |
20150315726 | FABRICATION OF BISCROLLED FIBER USING CARBON NANOTUBE SHEET - Fabrication of yarns or other shaped articles from materials in powder form (or nanoparticles or nanofibers) using carbon nanotube/nanofiber sheet as a platform (template). This includes methods for fabricating biscrolled yarns using carbon nanotube/nanofiber sheets and biscrolled fibers fabricated thereby. | 11-05-2015 |
20150320838 | COMPOSITION AND FORMULATION FOR TOPICAL TREATMENT OF INFLAMMATION AND TISSUE DAMAGE - The present invention relates to a composition for use in the treatment by topical administration of inflammatory diseases associated with tissue degeneration and/or tissue damage in humans or animals, comprising dehydrated avian egg albumen. | 11-12-2015 |
20150328277 | ORAL TRANSMUCOSAL DELIVERY OF GLATIRAMER ACETATE - The present invention provides an oral patch comprising:
| 11-19-2015 |
20150342998 | COMPOSITIONS AND METHODS - The invention relates generally to the fields of biology and life sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in morselized amniotic membrane tissue and morselized umbilical cord tissue preparations. | 12-03-2015 |
20150343111 | HEMOSTATIC TEXTILE - A hemostatic textile comprising glass fibers circular knit with bamboo-sourced rayon fibers in a tubular fashion. The knitted textile is scoured and dried to shrink the bamboo-sourced rayon relative to the glass fibers and to orient the glass fibers exteriorly of the bamboo-sourced rayon fibers such that when the hemostatic textile is administered to a wound, the glass fibers are the first to come in contact with any wound fluid, for example blood. This orientation aids in the activation of the hemostatic response which leads to faster clot times and improved overall wound-healing. A method of manufacturing and utilizing the hemostatic textile is also provided. | 12-03-2015 |
20150359763 | USE OF 3-BROMOPYRUVATE AS A CONTRACEPTIVE - Disclosed herein are methods of inhibiting sperm motility. In some embodiments, a method of inhibiting sperm motility includes contacting a sperm with an effective amount of 3BP, thereby inhibiting sperm motility. Also disclosed herein are methods of contraception. In some embodiments, a method of contraception includes administering an effective amount of 3BP to the vagina so that sperm in contact with 3BP change their swimming patterns, which are incompatible with fertilization, thus preventing pregnancy. In one embodiment, a method includes topical application of 3BP to the penis in an amount effective to cause complete loss of motility of ejaculated sperm during sexual intercourse, thereby achieving contraception. In some examples, 3BP is administered as a spermicide in the forms of a jelly (gel), films, sponges, foams and timed-release mesh. In some examples, condoms are coated with 3BP-containing lubricant to achieve contraception. | 12-17-2015 |
20150366832 | CARBIDOPA/LEVODOPA GASTRORETENTIVE DRUG DELIVERY - A gastroretentive drug formulation for the sustained release of an active agent in the gastrointestinal tract comprises an internal layer or compartment comprising an active agent and one or more pharmaceutical excipients, of which at least one is a polymer and two membranes forming together an envelope around the inner membrane, each membrane comprising at least one polymeric combination of an enteric polymer which is not soluble in gastric juice, and an hydrophilic swelling polymer, and at least one plasticizer. | 12-24-2015 |
20150367041 | METHOD FOR MANUFACTURING NANO-HYDROXYAPATITE/POLY(LACTIC ACID) HYBRID NANO-COMPOSITE MEMBRANE MAT, NANO-HYDROXYAPATITE/POLY(LACTIC ACID) HYBRID NANO-COMPOSITE MEMBRANE MAT MANUFACTURED THEREBY, AND AIR-JET SPINNING APPARATUS THEREFOR - Provided is a preparing method of a nano hydroxyapatite/poly(lactic acid) hybrid nanocomposite membrane mat including: mixing a hydroxyapatite powder with poly(lactic acid) in a solvent; and preparing a hydroxyapatite/poly(lactic acid) composite mat on a substrate by nozzle-injecting the mixture obtained in the mixing by an air-jet spinning method. | 12-24-2015 |
20150374640 | UNIFORM FILMS FOR RAPID-DISSOLVE DOSAGE FORM INCORPORATING ANTI-TACKING COMPOSITIONS - The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent. | 12-31-2015 |
20150374878 | ANGIOGENIC DEVICES FOR WOUND CARE - Devices, such as dressing and implants, for treatment of chronic wounds comprising controlled delivery systems for butyric acid or salts, polymers, or derivatives thereof are provided. These devices are particularly useful when it is desirable to promote angiogenesis in a chronic wound. In the preferred embodiment, the implants are resorbable, provide a temporary scaffold for the in-growth of cells, tissues, and blood vessels to help regenerate the extracellular matrix, and deliver butyric acid to the chronic wound. The dressings and implants may also contain one or more antibiotics to treat or prevent infection in the wound, and/or inhibitors of proteases to modulate protease activity in the wound. | 12-31-2015 |
20160008294 | TRANSDERMAL DELIVERY SYSTEM | 01-14-2016 |
20160008295 | COMPOSITIONS AND METHODS FOR TREATING ROSACEA | 01-14-2016 |
20160015653 | FILMS AND DRUG DELIVERY SYSTEMS MADE THEREFROM - The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. The invention further relates to edible multi-layer films that dissolve in water. In particular, the edible multi-layer films have a first water-soluble film layer and one or more additional water-soluble film layers in at least partial face-to-face engagement with the first film layer. | 01-21-2016 |
20160015654 | ADHESIVE COMPOSITION FOR MEDICAL USE, PATCH FOR MEDICAL USE, AND METHOD FOR PRODUCING THE COMPOSITION - An adhesive composition for medical use of the present invention includes an acrylic copolymer, a medicament having a carboxyl group, and a base, the acrylic copolymer is prepared by copolymerization of a monomer mixture containing 0.1 to 2 mass % of an ethylenically unsaturated carboxylic acid monomer as a monomer A, 58 to 99.9 mass % of an alkyl(meth)acrylate ester having an alkyl group of 4 to 12 carbon atoms as a monomer B, 30 mass % or less of an alkyl(meth)acrylate ester having 1 to 3 carbon atoms as a monomer C, and 30 mass % or less of a monomer having an ethylenically unsaturated group other than those of the monomers A to C (the total of monomers A to D is taken as 100 mass %) as a monomer D, and the content of sulfuric acid in the acrylic copolymer is 700 ppm by mass or less. | 01-21-2016 |
20160015655 | TRANSDERMAL ESTROGEN DEVICE AND DELIVERY - Described are transdermal drug delivery systems for the transdermal administration of estrogen, comprising a polymer matrix and estrogen. Methods of making and using such systems also are described. | 01-21-2016 |
20160022600 | Enhanced Drug Delivery from Adhesives - Various adhesive compositions are described which comprise one or more active agents such as pharmaceutical agents. The adhesive compositions exhibit enhanced release characteristics. The incorporation of one or more absorbents in particular proportions and/or in conjunction with certain components improves release and release characteristics of active(s). Also described are related methods of improving release of biologically active agents from adhesives and related methods of use of the compositions and articles using such compositions. | 01-28-2016 |
20160022800 | TRANSCUTANEOUS DOSAGE FORMULATION - Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a subject, including applying, to at least a portion of the subject's post-auricular region, a topical delivery system including a therapeutically effective amount of a topical pharmaceutical composition comprising at least one active agent and a pharmaceutically acceptable carrier and/or adjuvant. The topical pharmaceutical composition can include a topical immunogenic composition. The topical delivery system can further include a flexible substrate in communication with the topical immunogenic composition. The subject can be a pediatric subject. | 01-28-2016 |
20160030624 | METHODS AND COMPOSITIONS FOR WOUND HEALING - The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound. | 02-04-2016 |
20160030634 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion. | 02-04-2016 |
20160038629 | Adhesive Properties - Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions. | 02-11-2016 |
20160038645 | POLYMERIC MESH WITH SELECTIVE PERMEABILITY, FOR THE REPAIR AND REGENERATION OF TISSUES - The present application describes a polymeric mesh for the repair and regeneration of tissues from an organism that comprises pores wherein at least 70% of the pores of the said mesh have a size smaller than the one required to confine the cells of the said tissues, and wherein at least 70% of the pores of the said mesh has a size superior than the one needed for the passage of interstitial fluids of the said tissues; the degradation time of the said polymeric mesh within the organism is at least 8 weeks; the said polymeric mesh has an apparent tensile strength superior than 1 MPa; the said polymeric mesh has an apparent elastic modulus superior than 0.1 MPa. The mesh described in this application allows that the “new tissue” formed presents very similar properties to the ones of the damaged tissue. | 02-11-2016 |
20160051510 | ORAL DISSOLVABLE FILM THAT INCLUDES PLANT EXTRACT - Films (ODFs) that include botanical extract are provided, as well as methods of making and using the same. | 02-25-2016 |
20160051595 | EXTERNAL-USE MEDICAMENT FOR CLEANING AND CARE OF THE OVARIES, VAGINA AND VULVA - An external-use agent for cleaning and caring ovaries, vagina and vulva, which is produced by medical raw materials consisting of propolis extract, zedoary oil, and mint leaf filtrate is provided. On the basis of different properties of each natural Chinese herbal material, using supercritical CO | 02-25-2016 |
20160067318 | FREE-STANDING BIODEGRADABLE PATCH - Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents. | 03-10-2016 |
20160067371 | FIBRINOGEN-BASED TISSUE ADHESIVE PATCHES - A novel fibrinogen-based tissue adhesive patch is disclosed. The patch comprises a backing made from a non-permeable biocompatible polymer film into which a fibrinogen-based sealant is incorporated. In preferred embodiments of the invention, the fibrinogen-based sealant comprises fibrinogen, thrombin, and CaCl | 03-10-2016 |
20160067379 | EXTRACELLULAR MATRIX FOR THE TREATMENT OF INTESTINAL DISEASE AND METHODS THEREOF - A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate. | 03-10-2016 |
20160074335 | FIBER/GRANULE COMPLEX FOR TREATMENT OF THE GI TRACT - A method for treating a gastrointestinal (GI) tract including providing a fiber/granule complex made of non-absorbable fibers having granules attached thereto, and ingesting the fiber/granule complex orally, wherein the fiber/granule complex treats materials in the GI tract as it passes through the GI tract, the fiber/granule complex not being substantially absorbed by the GI tract. | 03-17-2016 |
20160082068 | Topical Transdermal Method for Delivering Nutrients Through the Skin for Expeditied Wound Healing and Skin Rejuvenation - The present invention relates to liquid application for skin rejuvenation created from specific amino acids, lipids, nucleic acids and vitamins. This collection of molecules delivers precisely the factors necessary to a specific site requiring healing; a direct intervention system to most expeditiously remodel skin with building blocks. This delivery is a transdermal topical delivery and healing is via specific molecules that engender a false autocoid reaction rapidly followed by an incremental healing-anti-inflammatory response augmented by very specific GRAS ingredients in the invention and also recruited from the body to this needy site. Energy is brought to site by transdermally delivered protons and enhanced by the local vascular flow initiated by transdermal molecules. | 03-24-2016 |
20160089328 | SUBLINGUAL APOMORPHINE - The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith. | 03-31-2016 |
20160095821 | ABUSE-RESISTANT MUCOADHESIVE DEVICES FOR DELIVERY OF BUPRENORPHINE - The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized. | 04-07-2016 |
20160095851 | SUBLINGUAL APOMORPHINE - The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith. | 04-07-2016 |
20160101101 | SUBLINGUAL APOMORPHINE - The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith. | 04-14-2016 |
20160101126 | COMPOSITIONS COMPRISING NANOPARTICLES AND APOPTOTIC AGENTS AND METHODS OF USE - Compositions comprising nanoparticles, such as silver or gold nanoparticles or carbon nanotubes (CNTs), and apoptotic agents are described. The nanoparticles can significantly enhance the cancer chemotherapeutic effects of the apoptotic agents. In particular, a highly increased anti-tumor activity has been demonstrated for the combination of etoposide and CNTs against HeLa cells compared to the administration of either etoposide alone or nanoparticles alone. Data provided by flow cytometry, Caspase 3 and other methods, suggest a strong interaction between the nanoparticles and the cellular structure, which can result in the improved effectiveness of chemotherapeutic agents. These findings provide potential new cancer therapies by carefully selecting the right combination of cytostatic drugs and nanostructural materials which synergistically provide significantly greater curative rates. | 04-14-2016 |
20160101204 | Soluble Fibrous Structures and Methods for Making Same - Soluble fibrous structures and more particularly soluble fibrous structures that contain one or more fibrous elements, such as filaments, having one or more fibrous element-forming materials and one or more active agents present within the fibrous elements, wherein the fibrous structure exhibits improved dissolution properties compared to known soluble fibrous structures, and method for making such improved fibrous structures are provided. | 04-14-2016 |
20160120986 | DELIVERY SYSTEMS - Disclosed herein are delivery systems including coated and uncoated yarns, yarn precursors, threads, fibers, and other substrates for the constant or near-constant release of active compounds, as well as methods for manufacturing such delivery systems. The yarns, yarn precursors, threads, fibers, and other substrates can include a cross-linked hydrophobic elastomer and an active compound. One or more coatings that are impermeable or substantially impermeable to the active compound may partially or fully occlude the yarn or substrate to control release rates of the active compound. The delivery systems may be used in a variety of applications, including the making of articles of clothing, textiles, and fabrics, and may be used in methods of treating various conditions and diseases. | 05-05-2016 |
20160128947 | BIOADHESIVE FILMS FOR LOCAL AND/OR SYSTEMIC DELIVERY - Bioadhesive films suitable for topical, local, and systemic drug delivery and methods for making the same. The films may incorporate one or more polymeric layers that enable delivery of a specific, desired dosage, to a specific, desired location over a specific, desired time period. | 05-12-2016 |
20160128948 | PATCH - Provided is a patch that ensures high storage stability of donepezil or a salt thereof and allows stable transdermal administration of the donepezil or salt thereof in an amount that provides a pharmaceutical effect. The patch includes a substrate | 05-12-2016 |
20160128949 | TRANSDERMAL DRUG DELIVERY DEVICE INCLUDING AN OCCLUSIVE BACKING - A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer. | 05-12-2016 |
20160136322 | GELATIN SPONGE COMPRISING AN ACTIVE INGREDIENT, ITS PREPARATION AND USE - The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof. | 05-19-2016 |
20160151299 | SUBLINGUAL FILMS | 06-02-2016 |
20160158160 | NANOFIBROUS MATERIALS AS DRUG, PROTEIN, OR GENETIC RELEASE VEHICLES - The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment. | 06-09-2016 |
20160166703 | Carrier Molecule Compositions and Related Methods | 06-16-2016 |
20160168407 | INK FOR LASER IMAGING | 06-16-2016 |
20160174564 | BIOCIDE-FREE PREWETTED SPONGE CLOTH | 06-23-2016 |
20160184192 | SALINE NOSE WIPE AND METHODS OF MANUFACTURE AND USE - The present invention generally relates to a wet wipe or sheet that is suitable for contacting the skin and removing mucus from the skin. More specifically, the present invention relates to a wet wipe having an aqueous saline component suitable for dissolving and removing mucus in combination with the fabric matrix of the wet wipe. Typically, the fabric matrix of the wet wipe has a capacity of about 125 grams of solution per square meter, and it is impregnated with the aqueous saline solution to a level at or below approximately 80% of the absorbent capacity of the matrix. | 06-30-2016 |
20160184312 | TRANSDERMAL ADMINISTRATION SYSTEM FOR USE IN THE TREATMENT OF CHRONIC BRONCHOPULMONARY DISEASES - Transdermal administration system comprising doxofylline as the active ingredient, for use in the treatment of bronchopulmonary diseases having a broncho-obstructive component. | 06-30-2016 |
20160193157 | Delivery System for Active Agents | 07-07-2016 |
20160198725 | COMPOSITIONS AND METHODS FOR CONTROL OF MARINE ECTOPARASITES | 07-14-2016 |
20170231919 | DELIVERY SYSTEMS | 08-17-2017 |
20170231936 | DERMAL THERAPEUTIC SYSTEM WITH HIGH ADHESIVITY | 08-17-2017 |
20180023255 | TISSUE PAPER | 01-25-2018 |
20190142762 | Method for Producing Articles of Plant Origin Impregnated With a Liquid Plant Substance | 05-16-2019 |
20220133644 | MICROCELL SYSTEMS FOR DELIVERING BENEFIT AGENTS - A benefit agent delivery system whereby benefit agents can be released over a period of time and/or a variety of different benefit agents can be delivered from the same system and/or different concentrations of benefit agents can be delivered from the same system. The benefit agent delivery system includes a plurality of microcells, wherein the microcells are filled with a formulation comprising a benefit agent and an organic solvent. The microcells include an opening, and the opening is spanned by a porous diffusion layer. Different microcells may be loaded with different benefit agents, thereby providing a mechanism to deliver different, complimentary, or incompatible benefit agents. | 05-05-2022 |