| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 536240100 | Non-coding sequences which control transcription or translation processes (e.g., promoters, operators, enhancers, ribosome binding sites, etc.) | 17 |
| 20080221316 | siRNA targeting ethanolamine Kinase I1 (EKI1) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to EKI1. | 09-11-2008 |
| 20080227967 | siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to RRM2. | 09-18-2008 |
| 20090124794 | hTERT GENE EXPRESSION REGULATORY GENE - Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated. | 05-14-2009 |
| 20090149642 | ENRICHED PREPARATION OF HUMAN FETAL MULTIPOTENTIAL NEURAL STEM CELLS - The present invention relates to a method of separating multipotential neural progenitor cells from a mixed population of cell types. This method includes selecting a promoter which functions selectively in the neural progenitor cells, introducing a nucleic acid molecule encoding a fluorescent protein under control of said promoter into all cell types of the mixed population of cell types, allowing only the neural progenitor cells, but not other cell types, within the mixed population to express said fluorescent protein, identifying cells of the mixed population of cell types that are fluorescent, which are restricted to the neural progenitor cells, and separating the fluorescent cells from the mixed population of cell types, wherein the separated cells are restricted to the neural progenitor cells. The present invention also relates to an isolated human musashi promoter and an enriched or purified preparation of isolated multipotential neural progenitor cells. | 06-11-2009 |
| 20090156796 | Metastatic colon cancer specific promoter and uses thereof - Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia. | 06-18-2009 |
| 20100210832 | BIDIRECTIONAL PROMOTERS IN NANNOCHLOROPSIS - Exemplary embodiments provided herein include novel promoters isolated from the microalgae, Nannochloropsis. These promoters drive gene expression in a bidirectional manner, and are especially useful for the genetic manipulation of Nannochloropsis and other organisms. The inventors herein successfully used these promoters (in both parallel and antiparallel orientations with respect to a Sh ble gene cassette) to impart zeocine-resistance to Nannochloropsis. | 08-19-2010 |
| 20110166336 | Identification of New Small RNAs and ORFs of E. Coli as Mediators of Cell and Intercell Regulation - The invention relates to new small RNAs and ORFs of | 07-07-2011 |
| 20110166337 | Maize Promoter P67 and Methods of Use - A promoter isolated from | 07-07-2011 |
| 20120046456 | METHOD FOR THE PRODUCING ALPHA-1, 6-BRANCHED ALPHA-1, 4-GLUCANS FROM SUCROSE - Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus | 02-23-2012 |
| 20130090463 | POLYNUCLEOTIDES HAVING PROMOTER ACTIVITY - The present invention relates to isolated polynucleotides having promoter activity the juse of the isolated polynucleotides for the procuction of a polypeptide. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing a desired polypeptide using the polypeptide having promoter activity. | 04-11-2013 |
| 20130131330 | BIDIRECTIONAL PROMOTERS IN NANNOCHLOROPSIS - Exemplary embodiments provided herein include novel promoters isolated from the microalgae, | 05-23-2013 |
| 20130289262 | ACP Promoter - Isolated nucleotide sequences encoding a promoter of the Acyl Carrier Protein (“ACP”). | 10-31-2013 |
| 20140121364 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 05-01-2014 |
| 20140213779 | RIBOSWITCHES - The present invention relates to a system comprising a genetic construct a riboswitch operably linked to a regulatory sequence, and a second genetic construct a coding sequence whose expression is capable of being regulated by a gene product of the first construct. Also provided is a genetic construct comprising one or more riboswitches for regulation of gene expression, wherein preferably a spacer sequence is provided downstream of the riboswitch to enhance expression of a coding sequence which is operably linked to a riboswitch. Ligands, kits, methods, host cells and expression systems are also provided. | 07-31-2014 |
| 20150025231 | COMPOSITIONS AND METHODS FOR MODULATION OF IKBKAP SPLICING - The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia. | 01-22-2015 |
| 20160083722 | COMPOSABILITY AND DESIGN OF PARTS FOR LARGE-SCALE PATHWAY ENGINEERING IN YEAST - Expression cassettes comprising promoter and terminator combinations are provided and can be used to tune gene expression. Synthetic yeast promoters and methods of making them also are provided. | 03-24-2016 |
| 20160177304 | CRISPR-BASED COMPOSITIONS AND METHODS OF USE | 06-23-2016 |
