| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 536230100 |
DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)
| 882 |
| 536250400 |
Separation or purification of polynucleotides or oligonucleotides
| 178 |
| 536250300 |
Synthesis of polynucleotides or oligonucleotides
| 126 |
| 536260100 |
Phosphorus containing N-glycoside wherein the N is part of an N-hetero ring
| 123 |
| 536280100 |
N-glycosides wherein the N is part of a six-membered hetero ring (e.g., diazines, etc.)
| 88 |
| 536270100 |
N-glycosides wherein the N is part of an N-hetero ring which hetero ring is part of a polycyclo ring system containing an N-hetero ring and an additional hetero ring (e.g., rebeccamycin, etc.)
| 65 |
| 536280600 |
N-glycosides wherein the N is part of a five-membered hetero ring (e.g., selenazole nucleosides, pyrrole nucleosides, etc.)
| 9 |
| 536290100 |
Nitrogen of N-glycoside is acyclic nitrogen
| 7 |
| 536250600 |
Nucleic acids which include two or three nucleotide units | 5 |
| 20090099351 | NYLON POLYRIBONUCLEOSIDES - The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I) | 04-16-2009 |
| 20100121045 | BIS-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS - The present disclosure describes bis-modified bicyclic nucleosides and oligomeric compounds that can be prepared comprising at least one of these bis-modified bicyclic nucleosides. More particularly, the bis-modified bicyclic nucleosides have at least one substituent group at the 5′-methylene and on the bridge methylene and can be chiral. These bis-modified bicyclic nucleosides are expected to be useful for enhancing one or more property of oligomeric compounds including for example enhancing nuclease resistance. | 05-13-2010 |
| 20110137021 | SULFUR TRANSFER REAGENTS FOR OLIGONUCLEOTIDE SYNTHESIS - The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones, 5-phenyl-3H-1,2,4-dithiazole-3-thiones, and derivatives thereof as novel, efficient sulfur-transfer reagents is disclosed. Sulfur transfer from these reagents to compounds containing a P(III) atom (e.g., triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite), was studied in solution by | 06-09-2011 |
| 20110190485 | SOLID-SUPPORTED ETHER DISULFIDES - The present invention provides for compounds of Formulas I-III, and salts thereof, | 08-04-2011 |
| 20130041144 | 5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM - Provided herein are novel 5′-(S)—CH | 02-14-2013 |
| 536250100 |
3`-5` linked RNA | 1 |
| 20100324277 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION - The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification. | 12-23-2010 |
| 20100324277 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION - The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification. | 12-23-2010 |
| 536250500 |
Homopolymers having repeating sequences of four or more identical nucleotide units | 1 |
| 20110288285 | Novel reagent compounds and methods of making same - The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine. | 11-24-2011 |
| 536250100 |
3-5 linked RNA | 1 |
| 20100324277 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION - The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification. | 12-23-2010 |
| 20100324277 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION - The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification. | 12-23-2010 |
| Entries |
| Document | Title | Date |
|---|
| 20080221314 | Heteromolecular metal-humic (chelate) complexes - Heteromolecular metal-humic organic complexes of the type: | 09-11-2008 |
| 20080227964 | 2'-silyl containing thiocarbonate protecting groups for RNA synthesis - Nucleoside monomers, nucleic acids, e.g., oligonucleotides and polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein. Aspects of the invention include 2′ silyl containing thiocarbonate protecting groups. Corresponding compositions and methods are provided. | 09-18-2008 |
| 20080255345 | IRNA Agents Targeting CCR5 Expressing Cells And Uses Thereof - The invention relates to iRNA agents that preferably include a modification that targets CC chemokine receptor 5 (CCR5). The invention also relates to methods of making and using such modified iRNA agents. | 10-16-2008 |
| 20080300393 | Nucleotide oligomer, nucleotide polymer, method for determining structure of functional substance and method for manufacturing functional substance - A modified nucleotide n-mer (where n is an integer of 2 or more) is used which comprises a nucleoside unit with a substituent group introduced into the base, wherein the substituent group is bound to the base via a triple bond. Novel nucleotide oligomers, nucleotide polymers, and nucleosides which can be used as raw materials or intermediates in the synthesis of this nucleotide oligomer and nucleotide polymer, as well as novel techniques for structural determination and manufacture of a functional substance having high affinity for a target, are provided. | 12-04-2008 |
| 20090012279 | POLYNUCLEOTIDE LABELING REAGENT - The present invention provides a new labeling reagent for preparing modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N—SO | 01-08-2009 |
| 20090023904 | NUCLEIC ACID PURIFICATION INSTRUMENT - According to this invention, a nucleic acid purification instrument whereby it is possible to prevent dispersion of a mist that causes contamination upon discharge of a solution is realized. | 01-22-2009 |
| 20090118481 | High Affinity Nucleic Acid Ligands To Lectins - This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands. This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands. | 05-07-2009 |
| 20090118482 | COMPOUNDS AND METHODS FOR LABELING OLIGONUCLEOTIDES - The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. | 05-07-2009 |
| 20090192302 | 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS - The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance. | 07-30-2009 |
| 20090209747 | METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES - Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers. | 08-20-2009 |
| 20090281296 | PROCESS FOR THE PRODUCTION OF CONJUGATES FROM POLYSACCHARIDES AND POLYNUCELOTIDES - The present invention relates to a process for the production of a conjugate from a polynucleotide and a polysaccharide comprising the steps: a) provision of an aldonic acid of the polysaccharide or of a derivative thereof; b) reaction of the aldonic acid with an alcohol derivative, preferably a carbonate derivative of an alcohol, to an aldonic acid ester, preferably to an activated aldonic acid ester; and c) reaction of the aldonic acid ester with the polynucleotide, wherein the polynucleotide exhibits a functional amino group, wherein the reaction of the aldonic acid with the alcohol derivative in step b) takes place in a dry aprotic polar solvent. | 11-12-2009 |
| 20100174055 | ASSAY FOR BCR/ABL GENE REARRANGEMENT - The present invention provides a simple high-throughput assay for detecting bcr/abl translocations. The method includes qualitative PCR methods for identifying the particular amplified translocation (e1a2 or b2a3/b3a2) and real time PCR for quantifying an amount of bcr/abl transcript (e1a2, b2a3 and b3a2). Quantitative measurement of ber/abl transcript in accordance with the methods of the invention is useful for monitoring response to therapy. | 07-08-2010 |
| 20100216978 | WIREFRAME NANOSTRUCTURES - The present invention generally relates to nanotechnology and, in particular, to wireframe nanostructures which may be formed from nucleic acids. In various aspects, the invention relates to molecular structures having a plurality of vertices and pathways connecting the vertices, which may be formed from nucleic acids, including bundles or tubes of nucleic acids. Such molecular structures may form shapes such as icosahedrons, octahedrons, tetrahedrons, or other polyhedra, which may define an interior space. The interior space may be used, for example, to contain a molecule for further study, or to contain a molecule for drug delivery purposes. In some cases, the molecular structure may be stabilized using relatively short nucleic acid strands that interact with two or more nucleic acid portions within the structure, thereby substantially immobilizing the portions relative to each other. Other aspects of the invention relate to techniques for forming such molecular structures, techniques for using such molecular structures, techniques of promoting such molecular structures, kits involving such molecular structures, and the like. | 08-26-2010 |
| 20100216979 | 6-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS - The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance. | 08-26-2010 |
| 20110245478 | Method for the Synthesis of Oligonucleotide Derivatives - Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. | 10-06-2011 |
| 20120101266 | 18F-LABELED AZIDE COMPOUND, REAGENT FOR 18F-LABELING AND METHOD FOR 18F-LABELING OF ALKYNE COMPOUND USING SAME | 04-26-2012 |
| 20120165514 | SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES - The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α- | 06-28-2012 |
| 20140128586 | AMINO-LNA, THIO-LNA AND ALPHA-L-OXY-LN - A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved antisense properties. The novel oligonucleotides are composed of at least one LNA selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides. | 05-08-2014 |
| 20140275508 | ARTIFICIAL NUCLEIC ACIDS - Artificial nucleosides including 2-methyl-nucleobase-substituted butane-1,3-diol nucleosides are disclosed. Four different stereoisomers of such nucleosides are possible. Oligonucleotides made up of the artificial nucleosides form homoduplexes of greater stability than DNA duplexes and have a reduced ability to hybridize to DNA or RNA. | 09-18-2014 |
