Patent application number | Description | Published |
20100035344 | SOLUTIONS FOR TISSUE ENGINEERING AND METHODS OF USE - The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided. | 02-11-2010 |
20100222877 | Tissue Engineered Human Pulmonary Valves with Cyclic Pressure Bioreactor Accelerated Seeding Strategies and Methods For Assessing Inflammatory Potential of Putative Scaffolds for Tissue Engineered Heart Valves - The invention provides for bioengineered or tissue engineered heart valves that are more efficiently recellularized and/or have a decreased inflammatory potential. The heart valves are generally decellularized and then recellularized using autologous cells wherein the valves are subjected to pulsatile motion during the recellularization process. Tissue engineered heart valves subjected to the pulsatile motion are characterized by having at least 20% of the cells that remain on or in said previously decellularized tissue two weeks after the recellularization process are located below or interior to the basement membrane of said tissue. A method of making bioengineered tissues having these characteristic is also disclosed. Further provided is a bio-assay and related method for determining the inflammatory potential of a tissue. | 09-02-2010 |
20130280319 | Compositions, methods and kits for therapeutic treatment with wet spun microstructures - Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold. | 10-24-2013 |
20140148915 | GENERATING CK19-POSITIVE CELLS WITH HAIR-LIKE STRUCTURES FROM WHARTONS JELLY - A method of differentiating cells into CK19-positive cells capable of producing hair follicle-like and hair structure-like can include: providing a tissue scaffold; seeding cells into the scaffold, the cells being capable of differentiation; incubating the scaffold having the cells in a cell growth media; and incubating the scaffold having the cells in an osteogenic differentiation medium sufficient for CK19-positive cells to be generated in the scaffold. The tissue scaffold can be a decellularized Whartons' jelly matrix. The cell growth media excludes osteogenic differentiation components: dexamethasone, β-glycerophosphate, 1α,25-hydroxyvitamin D3, and ascorbic acid 2-phosphate. The osteogenic differentiation medium includes the osteogenic differentiation components. The cells can be mesenchymal cells, such as WJMSCs. | 05-29-2014 |
20150064780 | DISPOSABLE SINGLE USE SELF-CONTAINED CYCLIC PRESSURE AND FLOW BIOREACTOR SYSTEM - The present invention provides for a bioreactor system ( | 03-05-2015 |
Patent application number | Description | Published |
20090170722 | Methods of constructing and screening diverse expression libraries - The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the libraries are derived from two or more diverse characterized genomes. | 07-02-2009 |
20100166835 | Compositions and uses thereof for the treatment of wounds - The present invention provides a topical composition comprising (i) an amount of an AP-1 signaling inhibitor sufficient to reduce, delay or prevent apoptosis and/or necrosis induced by dermal wounding and/or to induce and/or enhance proliferation of a cell; and (ii) a suitable carrier or excipient e.g., a topical carrier or excipient or other carrier or excipient for dermal application. For example, the AP-1 signaling inhibitor is a peptide analog comprising the sequence set forth in SEQ ID NO: 104. The present invention also provides a method of treating a dermal wound comprising topically administering said topical composition to a subject suffering from a dermal wound. | 07-01-2010 |
20110218118 | PEPTIDE MODULATORS OF CELLULAR PHENOTYPE AND BI-NUCLEIC ACID FRAGMENT LIBRARY - The present invention provides a non-hybrid screening method for the identification and/or isolation of a peptide that is capable of modulating a phenotype in a cell, tissue or organism. For example, the non-hybrid screening method identifies a peptide that is derived from an organism that is unrelated to the cell, tissue or organism. Alternatively, or in addition, the non-hybrid screening method identifies a peptide that is capable of rescuing the cell, tissue or organism from cell death or inducing a cell, tissue or organism to grow. The present invention also provides a non-hybrid screening method for identifying a peptide that is useful for treating a disease and/or disorder. | 09-08-2011 |
20120178649 | METHODS OF CONSTRUCTING AND SCREENING DIVERSE EXPRESSION LIBRARIES - The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the libraries are derived from two or more diverse characterized genomes. | 07-12-2012 |
Patent application number | Description | Published |
20100000575 | Method Of On-Line Cleaning Of A Heat Exchanger In An Ethanol Plant - A method for on-line cleaning of a heat exchanger in an ethanol plant, including providing heat exchanger, wherein said heat exchanger has an inlet, and an internal surface, wherein said internal surface has accumulated undesired solids; providing an antifoaming agent to said inlet, during normal operation; providing a caustic to said inlet, during normal operation, and cleaning the internal surface of said accumulated undesired solids, during normal operation is provided. | 01-07-2010 |
20100000576 | Method of Cleaning Beer Preheaters In An Ethanol Plant - A method for cleaning exchangers including providing a heat exchanger with a liquid contact side and a vapor contact side, providing acid to clean the liquid contact side, and providing caustic to clean the vapor contact side is provided. In the method, the exchanger may be a beer preheater. In the method, the acid may be sulfamic acid. In the method, the liquid contact side may be the beer side. In the method, the exchanger may be a plate-in-frame heat exchanger or a a shell-and-tube heat exchanger. In the method, the acid may be provided from a central storage tank. In the method, there may be a recirculation pump. In the method, the acid may be provided from a local storage tank. | 01-07-2010 |
20100000849 | Method Of Prevention Of Ethanol In Rectification Column Bottoms In An Ethanol Plant - A method for preventing ethanol buildup in a column including providing a column with a bottom temperature and a next temperature above the bottom; providing a first advisory, wherein said first advisory comprises a temperature difference between said bottom temperature and said next temperature above the bottom that exceeds a first predetermined value, wherein a first action is taken should this first advisory occur; providing a second advisory, wherein said second advisory comprises a temperature depression of said bottom temperature of a second predetermined value, wherein a second action is taken should this second advisory occur, and providing a third advisory, wherein said third advisory comprises a temperature depression of said bottom temperature of a third predetermined value, wherein a third action is taken should this third advisory occur is provided. | 01-07-2010 |
20100000850 | Method Of Improving Rectifier Column Performance In An Ethanol Plant - A method for improving rectifier column performance including positioning a temperature controller on the rectifier column feed tray, wherein said temperature controller is outside the fusel draw region, and controlling distillate composition or temperature, wherein said control is cascaded to the rectifier column flow control is provided. | 01-07-2010 |