Angelika
Angelika Banzhoff, Marburg DE
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20100034830 | Rabies vaccine - The invention provides for an immunogenic rabies vaccine comprising a reduced vaccine dose and methods of pre- and post-exposure immunization with a reduced dose. The concentration of rabies vaccine antigen per dose is preferably less than 2.5 IU/mL. | 02-11-2010 |
20110200635 | COMBINED INFLUENZA VACCINES FOR SEASONAL AND PANDEMIC PROTECTION - Current approaches to influenza vaccination focus either on seasonal strains or pandemic strains. Current seasonal vaccines typically include antigens from two influenza A strains (H1N1 and H3N2) and one influenza B strain. Current pandemic vaccines focus on H5N1 influenza A virus strains. It is an object of the invention to provide further and improved ways of preparing vaccines that can raise immunity against both seasonal and pandemic strains. | 08-18-2011 |
20140363468 | COMBINED INFLUENZA VACCINES FOR SEASONAL AND PANDEMIC PROTECTION - Current approaches to influenza vaccination focus either on seasonal strains or pandemic strains. Current seasonal vaccines typically include antigens from two influenza A strains (H1N1 and H3N2) and one influenza B strain. Current pandemic vaccines focus on H5N1 influenza A virus strains. It is an object of the invention to provide further and improved ways of preparing vaccines that can raise immunity against both seasonal and pandemic strains. | 12-11-2014 |
Angelika Beottger, Germering DE
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20110130449 | Assay for Monitoring Activity of Jmjd6 - The invention provides a method for assaying Jmjd6 activity. | 06-02-2011 |
Angelika Bierhaus, Heidelberg DE
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20120115789 | Methylglyoxal-Scavenging Compounds and Their Use for the Prevention and Treatment of Pain and/or Hyperalgesia - The present invention relates to compounds which inhibit or antagonize the binding of methylglyoxal (MG) and/or other reactive carbonyl species (RCS) to an arginine- or lysine- containing protein, preferably an arginine- or lysine-containing cellular protein, such as a sodium ion channel, e.g. the sodium ion channel Na(v)1.8. Preferred scavenger compounds are peptides comprising several or multiple repeats of the amino acid sequence motif Gly-Glu-X-Pro (GEXP), wherein X is Arg or Lys, and pharmaceutical compositions thereof. The present invention furthermore relates to the use of the compounds as scavenger or antagonists of methylglyoxal and/or related reactive carbonyl species (RCS). The present invention furthermore relates to the use of the compounds for the prevention and/or treatment of pain, hyperalgesia and pain related diseases, in particular pain and/or hyperalgesia caused by or associated with methylglyoxal and/or reactive carbonyl species (RCS). | 05-10-2012 |
Angelika Bodenteich, Wien AT
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20080226713 | Controlled Release Pharmaceutical Compositions of Tolperisone for Oral Administration - The invention relates to a tolperisone-containing pharmaceutical preparation with controllable active-substance release for oral administration, characterised in that the active substance tolperisone and/or a pharmaceutical salt thereof is embedded in a pharmaceutically compatible material. By selecting the pharmaceutically compatible materials in the preparation and accordingly in the coating of a tablet or granule, a specific release of active substance can be adjusted which is matched to the special genotype in the metabolisation of tolperisone. At the same time, as a result of the very uniform and persistent release of tolperisone, the in vivo inversion of enantiomerically pure tolperisone that is known from the art can be adjusted in favour of the R(−)tolperisone which is prominent in muscle-relaxing therapy. | 09-18-2008 |
Angelika Bonauer, Frankfurt DE
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20100324118 | Method for the Promotion of Angiogenesis, Vascularization, or Vascular Repair or for the Inhibition of Tumor Angiogenesis - The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92. | 12-23-2010 |
20120322856 | Method for Promoting Angiogenesis, Vascularization, or Vessel Repair or for the Inhibiting Tumor Angiogenesis - The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92. | 12-20-2012 |
20150018407 | METHOD FOR PROMOTING ANGIOGENESIS, VASCULARIZATION OR VESSEL REPAIR OR FOR INHIBITING TUMOR ANGIOGENESIS - The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92. | 01-15-2015 |
Angelika Daser, Frankfurt/main DE
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20090191556 | Method - The present invention relates to a novel method for the delivery of agents to tumour cells. In particular it relates to a method for the specific delivery of agents to the interior of tumour cells. Uses of the method are also described. | 07-30-2009 |
Angelika Domschke, Duluth, GA US
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20090039535 | Extended Wear Ophthalmic Lens - A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen. | 02-12-2009 |
20090046242 | Extended Wear Ophthalmic Lens - An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa. | 02-19-2009 |
20100238398 | Extended Wear Ophthalmic Lens - An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa. | 09-23-2010 |
20140022507 | Extended Wear Ophthalmic Lens - A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen. | 01-23-2014 |
Angelika Fischer, Dreieich DE
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20090270287 | OIL COMPOSITION FOR LUBRICATING AN EGR EQUIPPED DIESEL ENGINE AND AN EGR EQUIPPED DIESEL ENGINE COMPRISING SAME - The present invention is directed to a lubricating oil composition, a diesel engine comprising a lubricating oil composition, and a method of lubricating a diesel engine provided with an exhaust gas recirculation system, comprising lubricating said engine with a lubricating oil composition comprising an oil of lubricating viscosity, and a polymeric N-dispersant booster comprising monomer units of: | 10-29-2009 |
Angelika Fretzen, Somerville, MA US
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20090062207 | Methods and compositions for the treatment of gastrointestinal disorders - The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 03-05-2009 |
20090191611 | Methods and Compositions for the Treatment of Gastrointestinal Disorders - The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 07-30-2009 |
20090253634 | Methods and Compositions for the Treatment of Gastrointestinal Disorders - The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastnoesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g. constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 10-08-2009 |
20100048489 | Stable Solid Formulation of A GC-C Receptor Agonist Polypeptide Suitable for Oral Administration - Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 02-25-2010 |
20110021419 | Methods and Compositions for the Treatment of Heart Failure and Other Disorders - Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described. | 01-27-2011 |
20110059903 | Formulations Comprising Linaclotide - The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions. | 03-10-2011 |
20110118184 | Treatments of Gastrointestinal Disorders - The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. | 05-19-2011 |
20120009225 | Stable Solid Formulation of Therapeutic Polypeptides Suitable for Oral Administration - Solid, stable formulations of therapeutic polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The therapeutic polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 01-12-2012 |
20120039949 | Stable Solid Formulations of GC-C Receptor Agonist Polypeptides Suitable for Oral Administration - Solid, stable formulations of GC-C receptor agonist polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The GC-C receptor agonist polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 02-16-2012 |
20120040892 | Methods and Compositions for the Treatment of Heart Failure and Other Disorders - Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described. | 02-16-2012 |
20120213846 | Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration - Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 08-23-2012 |
20130012454 | Orally Disintegrating Compositions of Linaclotide - The present invention relates to orally disintegrating or dissolving pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well to various methods and processes for the preparation and use of the compositions. | 01-10-2013 |
20130059797 | Linaclotide for the Treatment of Chronic Constipation - The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide. | 03-07-2013 |
20130085107 | Treatments for Gastrointestinal Disorders - The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. | 04-04-2013 |
20130130995 | Treatments for Gastrointestinal Disorders - Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein. | 05-23-2013 |
20130190238 | Treatments for Gastrointestinal Disorders - The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 07-25-2013 |
20130190239 | Formulations Comprising Linaclotide - The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions. | 07-25-2013 |
20130273169 | Stable Solid Formulation of GC-C Receptor Agonist Polypeptide Suitable for Oral Administration - Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 10-17-2013 |
20140005128 | TREATMENTS OF GASTROINTESTINAL DISORDERS | 01-02-2014 |
20140024593 | Treatments of Gastrointestinal Disorders - The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. | 01-23-2014 |
20140073571 | Treatments for Gastrointestinal Disorders - The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 03-13-2014 |
20140179607 | Treatments for Gastrointestinal Disorders - The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. | 06-26-2014 |
20140256634 | Treatments for Gastrointestinal Disorders - Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein. | 09-11-2014 |
20140287034 | Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration - Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 09-25-2014 |
20140323448 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 10-30-2014 |
20140342996 | Treatments for Gastrointestinal Disorders - The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation. | 11-20-2014 |
20140348942 | Treatments for Gastrointestinal Disorders - The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention. | 11-27-2014 |
20140349948 | Treatment of Chronic Constipation - The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide. | 11-27-2014 |
20140378393 | Stable Formulations of Linaclotide - The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions. | 12-25-2014 |
20150018353 | 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS - Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 01-15-2015 |
20150030697 | TREATMENTS FOR GASTROINTESTINAL DISORDERS - The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation. | 01-29-2015 |
20150031632 | Orally Disintegrating Compositions of Linaclotide - The present invention relates to orally disintegrating or dissolving pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions. | 01-29-2015 |
20150094265 | Treatments for Gastrointestinal Disorders - The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein. using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 04-02-2015 |
20150094272 | Treatments for Gastrointestinal Disorders - The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 04-02-2015 |
20150119328 | Treatments for Gastrointestinal Disorders - Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein. | 04-30-2015 |
20150132375 | Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration - Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug. | 05-14-2015 |
20150175599 | FAAH Inhibitors - The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1. | 06-25-2015 |
20150274712 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 10-01-2015 |
Angelika Fruhwirth, Innsbruck AT
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20110033416 | RNA Vaccines - The present invention relates to an RNA vaccine comprising an RNA molecule encoding an allergen or derivative thereof and uses thereof. | 02-10-2011 |
20140134129 | RNA Vaccines - A RNA vaccine containing a RNA molecule encoding an allergen or derivative thereof, in which the allergen is an allergen of | 05-15-2014 |
Angelika Glienke, Burgkemnitz DE
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20120253090 | SPHERICAL ZEOLITIC CATALYST FOR CONVERTING METHANOL INTO OLEFINS - A catalyst containing a pentasil-type alumosilicates and a binder, in the form of spheres having an average diameter between 0.3 and 7 mm, wherein the BET surface area of the catalyst ranges from 300 to 600 m | 10-04-2012 |
Angelika Gohle, Schwegenheim DE
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20090261032 | Filter element with active carbon coating - A filter element has a first filter layer that has an active carbon layer, a top cover layer connected to the active carbon layer and a bottom cover layer connected to the active carbon layer opposite the top cover layer, wherein the first filter layer is folded to a first bellows. At least one second filter layer having an active carbon layer, a top cover layer connected to the active carbon layer and a bottom cover layer connected to the active carbon layer opposite the top cover layer is provided. The at least one second filter layer is folded to a second bellows. The first and second bellows are folded identically. The at least one second filter layer is arranged on the first filter layer in a positive-locking way by fold alignment of the first and second bellows to form a composite of filter layers. | 10-22-2009 |
20140013941 | AIR FILTER OPERABLE FOR FILTERING CABIN AIR IN VEHICLES, AGRICULTURAL MACHINERY, CONSTRUCTION EQUIPMENT AND OTHER WORK MACHINES - The invention relates to an air filter element of a passenger compartment for the driver's cab of agricultural and work machines, in particular with spraying and atomizing devices for pesticides and fertilizers, comprising an adsorption filter layer with activated carbon, a fine filter layer in particular for separating aerosols and a circumferential sealing for separating the raw side from the clean side during installation into a filter housing. | 01-16-2014 |
Angelika Hanschmann, Frankfurt Am Main DE
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20100190751 | NOVEL COMBINATION OF NERAMEXANE FOR TREATMENT OF NERORDEGENERATIE DISORDERS - The present invention relates to combinations comprising neramexane and a Glutamate Release Inhibitor (GRI) and the use of such combinations in the treatment of neurodegenerative disorders. | 07-29-2010 |
20100234358 | NERAMEXANE FOR THE TREATMENT OF NYSTAGMUS - The present invention relates to the treatment of an individual diagnosed with nystagmus comprising administering to the individual an effective amount of a 1-aminoalkylcyclohexane derivative, for example neramexane or a pharmaceutically acceptable salt thereof, such as neramexane mesylate. | 09-16-2010 |
Angelika Hausser, Stuttgart DE
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20080300207 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 12-04-2008 |
20090018099 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 01-15-2009 |
20130177919 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 07-11-2013 |
20130196430 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 08-01-2013 |
20130197196 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 08-01-2013 |
20150140591 | CELL ENGINEERING USING RNAs - The invention concerns the field of cell culture technology. It concerns RNA having a specific sequence, expression vectors encoding said RNA, production host cell lines comprising said RNA, and methods of producing recombinant biopharmaceutical products using engineered host cell with altered levels of said RNAs, such as small non-coding RNAs, preferably microRNAs (miRNAs). The invention also relates to engineered host cells with altered levels in one or more of said RNAs. Those cell lines have improved secretion and/or growth characteristics in comparison to control cell lines. | 05-21-2015 |
Angelika Hilgenrainer, Miesbach DE
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20120098249 | SECURITY ELEMENT, SECURITY SYSTEM AND PRODUCTION METHODS THEREFOR - The invention relates to a security element for security papers, value documents or the like, with a carrier having an upper side and a lower side and comprising several reflective first micro-imaging elements flatly arranged in a first pattern, and second micro-imaging elements flatly arranged in a second pattern, a first microstructure object which contains several first microstructures which are arranged in a first microstructure pattern so adapted to the first pattern that the first microstructure object is imaged in magnified form in front of the upper side by means of the first micro-imaging elements, and a second microstructure object which contains several second microstructures which are arranged in a second microstructure pattern so adapted to the second pattern that the second microstructure object is imaged in magnified form in front of the underside by means of the second micro-imaging elements. | 04-26-2012 |
20120153607 | SECURITY ELEMENT FOR AN ARTICLE TO BE PROTECTED AND ARTICLE TO BE PROTECTED WITH SUCH A SECURITY ELEMENT - The invention relates to a security element for an article to be protected, having an upper face and a lower face, one or more imaging optical arrangements, which all image a respective associated object to a magnified scale only in front of the upper face, wherein the one optical arrangement or at least one of the optical arrangements comprises a plurality of reflective micro-imaging elements arranged two-dimensionally in a first pattern, and the associated object is in the form of a microstructure object having a plurality of microstructures, which are arranged in a microstructure pattern so matched to the first pattern that the microstructure object is imaged to a magnified scale in front of the upper face by means of the reflective micro-imaging elements. On both its upper face and its lower face the security element has an adhesive layer ( | 06-21-2012 |
Angelika Hoffmann, Berlin DE
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20100219333 | METHOD AND KIT FOR CALIBRATING A PHOTOLUMINESCENCE MEASUREMENT SYSTEM - The invention is directed to a method and a kit for calibrating a photoluminescence measurement system, in particular a fluorescence measurement system. The kit includes a number of fluorescence standards i and their corrected and certified fluorescence spectra I | 09-02-2010 |
Angelika Hofmann, Muenchen DE
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20150254487 | 2D BARCODE SCANNER - A 2D barcode scanner ( | 09-10-2015 |
Angelika Keller, Bohl-Iggelheim DE
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20100004348 | EXPANDABLE STYRENE POLYMERS AND FOAMS WITH DECREASED WATER ABSORPTION - The present invention relates to an expandable styrene polymer which comprises athermanous particles and has been coated with a hydrophobicizing agent, which comprises from 10 to 90% by weight of at least one triester of at least one fatty acid with a polyhydric alcohol, as component A, from 5 to 70% by weight of at least one monoester of a fatty acid with a polyhydric alcohol, as component B, from 5 to 80% by weight of at least one metal salt of a fatty acid, as component C, from 5 to 50% by weight of at least one silicate, as component D, and from 0 to 30% by weight of at least one antistatic agent, as component E, and the entirety of components A to E of the hydrophobicizing agent amounts to 100% by weight, to a process for preparation of expandable styrene polymer, via coating of an expandable styrene polymer, which comprises athermanous particles, with a hydrophobicizing agent, to a foam produced from this expandable styrene polymer, and also to the use of a hydrophobicizing agent for coating of expandable styrene polymers comprising athermanous particles. | 01-07-2010 |
Angelika Koschany, Munchen DE
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20120067344 | RESPIRATORY MASK, RESPIRATORY MASK ARRANGEMENT, RESPIRATION SYSTEM AND PACKAGING UNIT - A respiratory mask for artificially ventilating a patient, having: a nose receiving chamber; first and second fastening tabs each being arranged on respective nose wing portions of the nose receiving chamber and a third fastening tab being arranged on a nose root portion of the nose receiving chamber. A respiratory mask arrangement can include such a respiratory mask; a hat arranged on the head of the patient; and fastening means which cooperate with the fastening tabs and with the hat in order to fix the respiratory mask to the head of the patient. A respiration system can include such a respiratory mask arrangement; and a respiration device for producing a continuous positive airway pressure. A packaging unit can include such a respiratory mask having a border with a peripheral groove; a sealing means which is arranged in the peripheral groove and a protective film for covering the sealing means. | 03-22-2012 |
Angelika Krenkow, Munich DE
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20100026988 | ONLINE SENSOR FOR MONITORING CHEMICAL CONTAMINATIONS IN HYDRAULIC FLUIDS - An online sensor for monitoring chemical contaminations in hydraulic fluids, having a receiving device for the fluid to be monitored, the device having observations windows disposed on two opposite sides, is characterized in that the online sensor has an IR emitter and an IR detector comprising at least two, preferably four detector fields for IR spectroscopy, wherein the fields are disposed opposite of each other on both observations windows. This provides a sensor that is capable of detecting the maintenance-relevant parameters of hydraulic fluids based on phosphate esters online, which is to say without having to withdraw the same from the airplane's hydraulic system and remove the same as a sample. | 02-04-2010 |
20120170025 | ONLINE SENSOR FOR MONITORING CHEMICAL CONTAMINATIONS IN HYDRAULIC FLUIDS - An online sensor for monitoring chemical contamination in a phosphate ester-based hydraulic fluid includes a receiving unit for the hydraulic fluid having two viewing windows arranged on opposite sides, an IR emitter, and an IR detector having four detector fields for IR spectroscopy, with the IR emitter and the IR detector being arranged on the two viewing windows in a mutually opposed manner. The online sensor also includes an optical filter having four fields for IR transmission bands with different wave numbers being provided between one viewing window and the IR detector for qualitative and quantitative evaluation of the contaminations, wherein a first IR transmission band has a wave number of 3400 cm-1, a second IR transmission band has a wave number of 3500 cm-1, a third IR transmission band has a wave number of 3600 cm-1, and a fourth IR transmission band is provided as a reference field. | 07-05-2012 |
Angelika Leukling, Bochum DE
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20110275528 | MARKER SEQUENCES FOR INFLAMMATORY PROSTATE DISEASES, PROSTATE CARCINOMA AND THEIR USE - The present invention relates to novel marker sequences for inflammatory prostate diseases, prostate carcinoma and the diagnostic use thereof together with a method for screening of potential active substances for inflammatory prostate diseases, prostate carcinoma by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for inflammatory prostate diseases, prostate carcinoma, in particular a protein biochip and the use thereof. | 11-10-2011 |
Angelika Lueking, Bochum DE
Patent application number | Description | Published |
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20120264634 | Marker Sequences for Pancreatic Cancer Diseases, Pancreatic Carcinoma and Use Thereof - The present invention relates to novel marker sequences for pancreatic cancer diseases, pancreatic carcinoma and the diagnostic use thereof together with a method for screening of potential active substances for pancreatic cancer diseases, pancreatic carcinoma by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for pancreatic cancer diseases, pancreatic carcinoma, in particular a protein biochip and the use thereof. | 10-18-2012 |
20130029864 | BIOMARKERS FOR ALZHEIMER'S DISEASE - The invention relates to novel marker sequences for Alzheimer's disease, in particular Alzheimer's dementia, and their diagnostic use including a screening method in order to identify potential drugs for the treatment/prophylaxis of Alzheimer's disease by means of the said novel marker sequences. Moreover, the invention relates to a diagnostic device comprising said novel marker sequences for diagnosing Alzheimer's disease, particularly a protein array (chip) and its use hereto. | 01-31-2013 |
20130217591 | Marker Sequences for Inflammatory Prostate Diseases, Prostate Carconoma and Their Use - The present invention relates to novel marker sequences for inflammatory prostate diseases, prostate carcinoma and the diagnostic use thereof together with a method for screening of potential active substances for inflammatory prostate diseases, prostate carcinoma by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for inflammatory prostate diseases, prostate carcinoma, in particular a protein biochip and the use thereof. | 08-22-2013 |
20130244897 | Marker Sequences for Multiple Sclerosis and Use Thereof - The invention relates to novel marker sequences for multiple sclerosis and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for multiple sclerosis diseases the marker sequences. The invention further relates to a diagnostic device containing such marker sequences for multiple sclerosis, especially to a protein biochip and the use thereof. | 09-19-2013 |
20130303395 | MARKER SEQUENCES FOR SYSTEMIC LUPUS ERYTHEMATOSUS AND THE USE THEREOF - The invention relates to novel marker sequences for systemic lupus erythematosus and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for systemic lupus erythematosus diseases using said marker sequences. The invention further relates to a diagnostic device containing such marker sequences for systemic lupus erythematosus, especially to a protein biochip and the use thereof. | 11-14-2013 |
20140018245 | MARKER SEQUENCES FOR MULTIPLE SCLEROSIS AND USE THEREOF - The invention relates to novel marker sequences for multiple sclerosis and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for multiple sclerosis diseases using said marker sequences. The invention further relates to a diagnostic device containing such marker sequences for multiple sclerosis, especially to a protein biochip and the use thereof. | 01-16-2014 |
20140179557 | MARKER SEQUENCES FOR DIAGNOSING PROSTATE CANCER, AND USE THEREOF - The present invention relates to novel marker sequences for prostate carcinoma while excluding inflammatory prostate diseases or diabetes or polymorbidity and relates to their diagnostic use including a method for screening potential active substances for such prostate diseases by means of these marker sequences. The invention furthermore relates to a diagnostic device including such marker sequences for prostate carcinoma, in particular a protein biochip and its use. | 06-26-2014 |
20140309133 | Novel Method for Diagnosis of High-Affinity Binders and Marker Sequences - The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterisation and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal. | 10-16-2014 |
20140371095 | NOVEL METHOD FOR IDENTIFYING SPECIFIC MARKER SEQUENCES FOR PROSTATE CANCER - The present invention relates to a novel method for identifying specific marker sequences for diagnosis of prostate cancer and/or for prognosis in prostate cancer, and to the use of the specific marker sequences identified with the aid of this method. | 12-18-2014 |
20150197820 | MARKER SEQUENCES FOR INFLAMMATORY PROSTATE DISEASES, PROSTATE CARCINOMA AND THEIR USE - The present invention relates to novel marker sequences for inflammatory prostate diseases, prostate carcinoma and the diagnostic use thereof together with a method for screening of potential active substances for inflammatory prostate diseases, prostate carcinoma by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for inflammatory prostate diseases, prostate carcinoma, in particular a protein biochip and the use thereof. | 07-16-2015 |
Angelika Lüking, Bochum DE
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20090246203 | METHOD FOR IMMUNOADSORPTION BY MEANS OF AUTOANITGENS - The invention relates to a novel method for immunoadsorption therapy of human autoimmune diseases by means of immobilized or fixed autoantigens. | 10-01-2009 |
20100261881 | MARKER SEQUENCES FOR RHEUMATOID ARTHRITIS AND USE THEREOF - The present invention relates to new marker sequences for rheumatoid arthritis and the diagnostic use thereof together with a method for screening of potential active substances for rheumatoid arthritis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for rheumatoid arthritis, in particular a protein biochip and the use thereof. | 10-14-2010 |
20100280224 | MARKER SEQUENCES FOR MULTIPLE SCLEROSIS AND USE THEREOF - The present invention relates to new marker sequences for multiple sclerosis and the diagnostic use thereof together with a method for screening of potential active substances for multiple sclerosis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for multiple sclerosis, in particular a protein biochip and the use thereof. | 11-04-2010 |
20100331201 | PROTEIN BIOCHIP FOR THE DIFFERENTIAL SCREENING OF PROTEIN-PROTEIN INTERACTIONS - The present invention relates to a system of protein binders containing at least one protein binder presented in at least one native form and at least one non-native form and its use including a method for discrimination and/or differential screening of suitable protein binders in native and non-native form. | 12-30-2010 |
20110184375 | MARKER SEQUENCE FOR NEURODEGENERATIVE DISEASES AND THE USE THEREOF - The present invention relates to new marker sequences for neurodegenerative diseases and the diagnostic use thereof together with a method for screening of potential active substances for neurodegenerative diseases by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for neurodegenerative diseases, in particular a protein biochip and the use thereof. | 07-28-2011 |
Angelika Lüking, Bochum DE
Patent application number | Description | Published |
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20090124509 | Protein-biochip for validating binding agents - The invention relates to an arrangement of proteins containing at least one cDNA-expression library and to the use thereof as a protein-biochip, in particular for validating binding agents and protein binding agents and to a method for determining in a simultaneous manner quantitative variables. | 05-14-2009 |
20090246203 | METHOD FOR IMMUNOADSORPTION BY MEANS OF AUTOANITGENS - The invention relates to a novel method for immunoadsorption therapy of human autoimmune diseases by means of immobilized or fixed autoantigens. | 10-01-2009 |
20100261881 | MARKER SEQUENCES FOR RHEUMATOID ARTHRITIS AND USE THEREOF - The present invention relates to new marker sequences for rheumatoid arthritis and the diagnostic use thereof together with a method for screening of potential active substances for rheumatoid arthritis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for rheumatoid arthritis, in particular a protein biochip and the use thereof. | 10-14-2010 |
20100280224 | MARKER SEQUENCES FOR MULTIPLE SCLEROSIS AND USE THEREOF - The present invention relates to new marker sequences for multiple sclerosis and the diagnostic use thereof together with a method for screening of potential active substances for multiple sclerosis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for multiple sclerosis, in particular a protein biochip and the use thereof. | 11-04-2010 |
20100331201 | PROTEIN BIOCHIP FOR THE DIFFERENTIAL SCREENING OF PROTEIN-PROTEIN INTERACTIONS - The present invention relates to a system of protein binders containing at least one protein binder presented in at least one native form and at least one non-native form and its use including a method for discrimination and/or differential screening of suitable protein binders in native and non-native form. | 12-30-2010 |
20140371098 | MARKER SEQUENCES FOR BREAST CANCER AND THE USE THEREOF - The present invention relates to a method for identifying marker sequences for breast cancer, the marker sequences identified with the aid of this method and diagnostic use thereof, diagnostic devices containing marker sequences for breast cancer, in particular an arrangement and a protein array, and use thereof. The invention also relates to method for the screening of potential active agents for the treatment and prevention of breast cancer by means of these marker sequences. | 12-18-2014 |
20150024962 | MARKER SEQUENCES FOR MULTIPLE SCLEROSIS AND USE THEREOF - The present invention relates to new marker sequences for multiple sclerosis and the diagnostic use thereof together with a method for screening of potential active substances for multiple sclerosis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for multiple sclerosis, in particular a protein biochip and the use thereof. | 01-22-2015 |
20150087548 | MARKER SEQUENCES FOR RHEUMATOID ARTHRITIS AND USE THEREOF - The present invention relates to new marker sequences for rheumatoid arthritis and the diagnostic use thereof together with a method for screening of potential active substances for rheumatoid arthritis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for rheumatoid arthritis, in particular a protein biochip and the use thereof. | 03-26-2015 |
20150177247 | METHOD FOR IDENTIFYING MARKER SEQUENCES FOR GYNAECOLOGICAL MALIGNANT TUMOURS - The present invention relates to a method for identifying marker sequences for gynaecological malignoma, the marker sequences identified with the aid of this method and diagnostic use thereof, diagnostic devices containing marker sequences for gynaecological malignoma, in particular an arrangement and a protein array, and use thereof. The invention also relates to method for the screening of potential active agents for the treatment and prevention of gynaecological malignoma by means of these marker sequences. | 06-25-2015 |
20150293120 | MARKER SEQUENCES FOR RHEUMATOID ARTHRITIS - The present invention relates to a novel method for identifying marker sequences for rheumatoid arthritis, the novel marker sequences discovered with the aid of the method, and the diagnostic use thereof. The invention also relates to diagnostic devices containing such marker sequences for rheumatoid arthritis, in particular a protein biochip or beads (pellets), and use thereof. | 10-15-2015 |
Angelika Merthan, Konstanz DE
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20140197066 | COMPOSITE FILM FOR PRODUCTION OF MOULDED PACKAGING, METHOD FOR PRODUCTION OF A COMPOSITE FILM AND A MOULDED PACKAGING, AND MOULDED PACKAGING - A laminated film for production of molded packaging, in particular blister packs, with a layer structure comprising an inner first plastic layer, in particular of HDPE, an aluminum layer, which is connected with the first plastic layer by way of a connecting layer, and on the side opposite the first plastic layer is connected, preferably by way of a primer layer and a further connecting layer, to a second plastic layer, in particular comprising OPA. The second plastic layer is connected to a PET layer by way of a connecting layer and that the PET layer has a thickness between 150 μm and 300 μm, preferably a thickness between 200 μm and 300 μm. | 07-17-2014 |
Angelika Mueller, Jena DE
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20090042773 | P13 kinase gamma inhibitors for the treatment of anaemia - This present invention is related to the use of selective PD Kinase gamma inhibitors for the manufacture of a medicament for the treatment of disorders related to erythrocyte deficiency. Specifically, the present invention is related to the use of selective PI3 Kinase gamma inhibitors, e.g. substituted azolidinone-vinyl fused-benzene derivatives for the treatment of an anaemia, including haemolytic anaemia, aplastic anaemia and pure red cell anaemia. (I) wherein A, X, Y | 02-12-2009 |
Angelika Muscate-Magnussen, Hamburg DE
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20090032400 | Use of support materials in capillary electrochromatography - Use of a support material for capillary electrochromatography (CEC), characterized in that the support material has a porous design and a surface which consists of an outer surface and a pore surface, wherein the outer surface has regions of different derivatization and/or functionality from that of the pore surface. | 02-05-2009 |
Angelika Namberger, Altenmarkt A.d. Alz DE
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20080314374 | Cooking Appliance, Especially Top-Mounted Cooking Appliance, and Method for Controlling a Cooking Appliance - A cooking appliance, especially a top-mounted cooking appliance including a muffle that defines a cooking space and is provided with a muffle access opening; a door pivotably mounted to the muffle for movement into and our of a covering relation with the access opening; a driving device in operative engagement with the door; a control device operatively associate with the driving device for controlling door movement; and an arrangement for determining a door displacement parameter during door movement, wherein a determined door displacement parameter is used as a reference parameter for a function of the appliance. | 12-25-2008 |
20090001069 | Cooking Appliance, Especially Built-In Wall Cooking Appliance, and Method For Controlling a Cooking Appliance - A cooking appliance including a high-level cooking appliance having a muffle including a muffle compartment defining a cooking compartment with a muffle opening, a door for movement between an open and closed relationship with the muffle opening and a drive device controlled by a control device for moving the door, the cooking appliance including a detector for determining a trapping condition wherein an object becomes trapped as the door is being moved, wherein the detector is configured for detecting the trapping state by comparing a door movement parameter with a threshold value associated with door movement. | 01-01-2009 |
Angelika Osbon, Allen, TX US
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20100163349 | ELEVATOR HOISTWAY INSTALLATION GUIDE SYSTEMS, METHODS AND TEMPLATES - A template for accurately positioning structural components of elevator(s) in a elevator hoistway(s), or of elevator hoistway walls or partitions in a building, includes a thin, flexible sheet of material adapted to be placed on a floor of elevator hoistway(s), has indicia on the flexible sheet of material to show locations, and points of attachment, of elevator structural components which are to be installed in the elevator hoistway(s). Tensioning elements attachable to the flexible sheet of material may be used to square up the flexible sheet of material. The template may be made by forming a thin, flexible sheet of material, providing indicia on the flexible sheet of material, and by providing tensioning elements to square up the flexible sheet of material. The flexible template may be placed on the floor of the elevator hoistway(s), squared, and the squared up template used as a guide to install the major elevator structural components. The template may, alternatively, be made of a substantially rigid, e.g., corrugated, sheet material and employ interconnected sections. | 07-01-2010 |
Angelika Pauls-Von Heyden, Stuttgart DE
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20110184302 | MEDICAL DETECTION DEVICE FOR THE DETECTION OF SLEEP APNEA AND/OR SLEEP HYPOPNEA - A medical detection device for detecting breathing disruptions during sleep includes a fastening arrangement for attaching a detecting arrangement to the human body, having at least one microphone for detecting breathing sounds and a logic arrangement configured to evaluate the breathing sounds. | 07-28-2011 |
Angelika Polity, Bad Nauheim DE
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20150203398 | THERMOCHROMIC GLASS COMPRISING A COATING OF NEUTRAL-COLOUR VANADIUM DIOXIDE - The invention relates to a coating of glass with thermochromic vanadium dioxide. The colouration of the vanadium dioxide is shifted from bronze to neutral (colourless) by a doping with alkaline earth metals, for example Ca, Sr and Br. The thermochromic effect is maintained at the same time. | 07-23-2015 |
Angelika Preetz, Werne DE
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20130197252 | Preparation of Tri-Alkyl Gallium or Tri-Alkyl Indium Compounds - Trialkyl metal compounds, such as trialkyl gallium and indium compounds, are prepared in high yield and high purity by the addition of a trialkyl aluminum compound to a mixture prepared by adding a metal trihalide, e.g., GaCl | 08-01-2013 |
Angelika Preetz, Rostock DE
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20110004005 | RHODIUM-PHOSPHORUS COMPLEXES AND THEIR USE IN RING OPENING REACTIONS - The present invention is directed to novel rhodium-phosphorus complexes of formula: [Rh(PP′)(solv) | 01-06-2011 |
Angelika Richter, Braunschweig, DE DE
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20090137641 | Potassium Channel Activators for the Prevention and Treatment of Dystonia and Dystonia-Like Symptoms - The present invention is directed to the prevention, reversal and medical treatment of dystonia and dyskinesia as well as other diseases related to movement disorders, both in human beings and animals by administering a neuronal potassium channel opener such as flupirtine, retigabine or maxipost. | 05-28-2009 |
20090318507 | Potassium Channel Activators for the Prevention and Treatment of Dystonia and Dystonia Like Symptoms - The present invention is directed to the prevention, reversal and medical treatment of dystonia and dyskinesia as well as other diseases related to movement disorders, both in human beings and animals by administering a neuronal potassium channel opener such as flupirtine, retigabine or maxipost. | 12-24-2009 |
Angelika Schingale, Regensburg DE
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20140048325 | CONTACT SURFACE ARRANGED ON A CARRIER FOR CONNECTING TO A COUNTER CONTACT SURFACE ARRANGED ON A FURTHER CARRIER, AND DEVICE COMPRISING A CONTACT SURFACE AND A COUNTER CONTACT SURFACE CONNECTED THERETO - A contact area is provided on a carrier for connection to a mating contact area on a further carrier using an adhesive containing conductive particles. The contact area includes at least one recess forming a drain channel for the adhesive, extending from one edge of the contact area to an opposing edge and having a width being less than an average diameter of the particles. Alternatively, the contact area includes boreholes extending from a main surface to an opposing main surface and having diameters being approximately equal to or smaller than the average diameter of the particles in at least one direction and a cavity is formed in the carrier beneath the contact area. Alternatively, integral moldings forming a turf structure are provided on the contact area and distances between the moldings are equal to or smaller than the average diameter of the particles in at least one direction. | 02-20-2014 |
Angelika Schmidt, Selfkant DE
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20100044070 | INSULATED WIRES FOR USE IN ELECTRONIC EQUIPMENT - The invention relates to insulated wires for use in electronic equipment, comprising an electrically conductive core and an insulating layer and/or a insulating jacket consisting of a flame retardant thermoplastic composition surrounding the electrically conductive core, wherein the flame retardant thermoplastic composition comprises (A) a thermoplastic polymer comprising a copolyester elastomer and/or a copolyamide elastomer, (B) a metal salt of a phosphinic acid of the formula [R | 02-25-2010 |
20100249287 | FLAME RETARDANT THERMOPLASTIC COMPOSITION AND MOULDED PART MADE THEREOF - The invention relates to a flame retardant thermoplastic composition comprising (i) a thermoplastic elastomer comprises a copolyester elastomer comprising (a) hard blocks and soft blocks consisting of segments of hard and soft polyester polymers linked by urethane groups and/or (b) hard blocks consisting of segments of a hard polyester polymer and soft blocks consisting of a long chain aliphatic dicarboxylic acid residue and/or a long chain aliphatic diol residue, wherein the hard and soft blocks are optionally linked by urethane and/or ester groups and (ii) a halogen free flame retardant system comprises a nitrogen containing flame retardant. The invention further relates to moulded parts made from the said composition. | 09-30-2010 |
20100307822 | FLEXIBLE FLAME RETARDANT INSULATED WIRES FOR USE IN ELECTRONIC EQUIPMENT - The invention relates to an insulated wire for use in electronic equipment, comprising an electrically conductive core and an insulating layer and/or an insulating jacket consisting of a flame retardant elastomeric composition surrounding the electrically conductive core, wherein the flame retardant elastomeric composition comprises a elastomeric polymer selected from the group consisting of styrenic block copolymers, thermoplastic elastomers and combinations thereof; and a metal salt of a phosphinic acid of the formula [R | 12-09-2010 |
20120018189 | FLEXIBLE FLAME RETARDANT INSULATED WIRES FOR USE IN ELECTRONIC EQUIPMENT - The invention relates to an insulated wire for use in electronic equipment, comprising an electrically conductive core and an insulating layer and/or an insulating jacket consisting of a flame retardant elastomeric composition surrounding the electrically conductive core, wherein the flame retardant elastomeric composition comprises a elastomeric polymer selected from the group consisting of styrenic block copolymers, olefinic thermoplastic elastomers and combinations thereof; and a metal salt of a phosphinic acid of the formula [R | 01-26-2012 |
20120035303 | NON-BLOOMING FLAME RETARDANT THERMOPLASTIC COMPOSITION - This invention relates to a flame retardant thermoplastic composition comprising a thermoplastic polymer composition; a flame retardant containing a phosphorus containing anion; a borate; and an acid scavenger. | 02-09-2012 |
20120128977 | POLYMER COMPOSITION AND CABLE COVER OF THAT COMPOSITION - Flame retardant polymer composition comprising: A) a copolyester elastomer containing a) hard polyester segments made up of repeating units derived from an aliphatic diol and an aromatic dicarboxylic acid, b) soft polyester segments containing repeating units derived from an aliphatic carbonate, B) 0-30 parts of one or more further polymers, C) 1-15 parts of a halogen containing flame retardant. D) 0-15 parts of a halogen-free flame retardant, wherein sum of the components A, B, C and D is 100 parts. | 05-24-2012 |
20130206448 | FLAME RETARDANT INSULATED ELECTRICAL WIRE - An insulated wire, comprising an electrical conductive core and an insulating layer of a polymer composition surrounding the electrically conductive core, which polymer compositions contains: (A) a metal salt of a phosphinic acid and/or a diphosphinic acid and or a polymer thereof, (B) ammoniumpolyphosphate (C) an oligomer or a polymer of a triazine derivative. | 08-15-2013 |
Angelika Schmitt, Worms DE
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20130129658 | Rheology Modifying and Setting Polymer, Composition thereof and Method for Making It - The invention relates to a polymer suited for modifying the styling performance and the rheology of a cosmetic preparation, a composition thereof, a method of making it as well as the use of said polymer and the composition respectively. The copolymer comprises at least one non-ionic ethylenically unsaturated C1-C4 (meth)acrylate as monomer A; an ethylenically unsaturated monomer B having as hydrogen bond donor an amide group, said ethylenically unsaturated monomer B being an ethylenically unsaturated monomer having a cyclic amide moiety, as monomer B1 and/or, an ethylenically unsaturated monomer having an acyclic amide group, as monomer B2; at least one ethylenically unsaturated carboxylic acid as monomer C; a macromonomer D; optionally at least one cross-linker E; and optionally at least one further monomer F. | 05-23-2013 |
Angelika Schneider, Feldkirchen, Bavaria DE
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20150326395 | METHOD FOR SETTING UP A SECURE CONNECTION BETWEEN CLIENTS - The invention relates to a method for authorising a second client (C | 11-12-2015 |
Angelika Schulz, Leverkusen DE
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20140066535 | METHOD FOR PRODUCING FLEXIBLE POLYURETHANE FOAM MATERIALS - The present invention relates to a method for producing flexible polyurethane foams, wherein an isocyanate component (component B) is used which comprises polyether carbonate polyol, and to the isocyanate component itself. The invention also provides an NCO-terminated, urethane group-comprising prepolymer obtainable by reaction of one or more polyisocyanates (B1) with one or more polyether carbonate polyols. | 03-06-2014 |
20150307647 | PROCESS FOR PRODUCING FLEXIBLE POLYURETHANE FOAMS WITH HIGH COMFORT VALUE AND LOW HYSTERESIS LOSSES - The present invention relates to a process for producing flexible polyurethane (PUR) foams with high comfort value and low hysteresis losses produced by reacting organic polyisocyanates containing di- and polyisocyanates of the diphenylmethane (MDI) group with polyoxyalkylene polyethers. | 10-29-2015 |
Angelika Sokolowa, Tiberias IL
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20150338575 | COATED OPTICAL FIBRES HAVING IMPROVED FEATURES - A waveguide for high efficiency transmission of high energy light useful in ablation procedures at predetermined bandwidths over predetermined distances comprising: an optical fiber core; a silanization agent; layered cladding surrounding the optical fiber core comprising: a first thin metal layer comprising at least two types of metals the first thin metal layer covalently bonded to the core and a second thin metal layer bonded to the second metal layer; and a catalyst component; wherein the silanization agent comprising organofunctional alkoxysilane molecule, such as 3-aminopropyltriethoxysilane (APTS), is a self supporting bridge between the surface of the optical fiber and the first metal layer; the first metal layer is uniformly chemisorbed onto the surface of the optical fiber by means of covalent Si—O—Si bonds with the optical fiber; further wherein the catalyst component derived from an activation solution for enhancing the layered cladding upon the optical fiber. | 11-26-2015 |
Angelika Sticlaru, Erlangen DE
Patent application number | Description | Published |
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20120117205 | Automatic Connectivity Analysis For A DICOM Network - A method, a computer program product, a system and a connectivity analyzer are disclosed for determining available communication functionalities during the configuration of a DICOM node in a DICOM network. According to an embodiment of the invention the available communication functionalities are registered automatically by way of test communication requests and analysis of the test communication responses. Following the analysis the result containing the detected communication functionalities can be provided automatically. The result is preferably provided in the configuration phase and already prior to the entry into operation of the respective DICOM node. | 05-10-2012 |
20140201341 | AUTOMATIC CONNECTIVITY ANALYSIS FOR A DICOM NETWORK - A method, a computer program product, a system and a connectivity analyzer are disclosed for determining available communication functionalities during the configuration of a DICOM node in a DICOM network. According to an embodiment of the invention the available communication functionalities are registered automatically by way of test communication requests and analysis of the test communication responses. Following the analysis the result containing the detected communication functionalities can be provided automatically. The result is preferably provided in the configuration phase and already prior to the entry into operation of the respective DICOM node. | 07-17-2014 |
Angelika Stocklinger, Salzburg AT
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20090098167 | PHL P 1 Allergen Derivative - Method for producing derivatives of wild-type protein allergen Phl p 1 with reduced allergenic activity compared to the wild-type allergen, comprising the following steps: providing wild-type protein allergen Phl p 1, fragmenting said wild-type protein allergen into at least three fragments, wherein at least one fragment of said at least three fragments comprises at least one T-cell epitope and said at least three fragments have a reduced allergenic activity or lack allergenic activity and rejoining said at least three fragments in an order differing from the order of the fragments in the wild-type allergen. | 04-16-2009 |
Angelika Szokalska, Lodz PL
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20130317102 | Novel Esters of (Acyloxymethyl)Acrylamide, a Pharmaceutical Composition Containing Them, and Their use as Inhibitors of the Thioredoxin - Thioredoxin Reductase System - The subject of the present invention are novel esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them and their use in the production of drugs for the prophylaxis or treatment of oncogenic diseases and diseases connected with increased cell proliferation. | 11-28-2013 |
Angelika Zimmermann, Ueberlingen DE
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20150274295 | HOLDING DEVICE FOR A DISPLAY AND/OR OPERATING UNIT FOR ATTACHING IN AN AIRCRAFT AND DISPLAY AND OPERATING DEVICE WITH A HOLDING DEVICE - A holding device for a display and/or operating unit for use in an aircraft on an aircraft seat is proposed, with a holding arm and an attachment device and a coupling unit for connecting the display and/or operating unit, wherein one end region of the holding arm is provided on the attachment device so as to be pivotable about an axis of rotation and the coupling unit for pivotably connecting the display and/or operating unit is provided on the opposite end region of the holing arm, and wherein the holding arm can take up a use position and a storage position on the attachment device. According to the invention, a spiral spring unit is arranged between the attachment device and the holding arm is such a manner that a torque is exerted on the holding arm by the spiral spring unit. | 10-01-2015 |
20150274296 | HOLDING DEVICE FOR A DISPLAY AND/OR OPERATING UNIT FOR USE IN AN AIRCRAFT AND DISPLAY AND OPERATING DEVICE WITH A HOLDING DEVICE - A holding device for a display and/or operating unit for use in an aircraft on an aircraft seat is proposed, with a holding arm and an attachment device and a coupling unit for connecting the display and/or operating unit, wherein one end region of the holding arm is provided on the attachment device so as to be pivotable about an axis of rotation and the coupling unit for pivotably connecting the display and/or operating unit is provided on the opposite end region of the holing arm, and wherein the holding arm can take up a use position and a storage position on the attachment device. According to the invention, a touch-latch system with a locking position and an unlocking position is arranged between the attachment device and the holding arm. | 10-01-2015 |