The Board of Regents of the University of Texas System Patent applications |
Patent application number | Title | Published |
20160136205 | TARGETING TYPE I NKT CELLS TO CONTROL INFLAMMATION - Embodiments are directed to methods and compositions for modulating cytokine responses in subject infected by a pathogen. | 05-19-2016 |
20160131662 | PROTEIN AND ANTIBODY PROFILING USING SMALL MOLECULE MICROARRAYS - Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a tool for monitoring the state of the immune system of a patient. This may be a generally useful tool for the diagnosis of many types of disease states. Similar techniques are employed to detect the post-translational modification of specific proteins, a tool for the visualization of induction of signal transduction pathways in cells and tissues treated with drugs. Finally, aspects of the invention teach a method for the creation of simpler arrays with less than 100 features that are, nonetheless, effective for protein profiling experiments. | 05-12-2016 |
20160130669 | RECOMBINASE POLYMERASE AMPLIFICATION (RPA) METHOD FOR LEISHMANIA SPP. AND TRYPANOSOMA CRUZI - Certain embodiments are directed to a sensitive isothermal amplification test based on the recombinase polymerase amplification (RPA) method that is capable of detecting <2 parasites in a biological sample. | 05-12-2016 |
20160130217 | OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE - The present invention includes bis- and tris-benzamide compounds that block AR signaling and have anticancer activity. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided. | 05-12-2016 |
20160128311 | SCREEN AND USE OF THERAPEUTICS FOR PANCREATIC DUCTAL ADENOCARCINOMA - The present disclosure relates to methods for screening compounds for treating pancreatic ductal adenocarcinoma (PDA) using a mouse model with an Rgs16::GFP reporter. Also described are combination therapies for treating pancreatic ductal adenocarcinoma (PDA) using taxanes, gemcitabine and an Axl kinase inhibitor. | 05-12-2016 |
20160122348 | COMPOUNDS AND ANTI-TUMOR NQO1 SUBSTRATES - Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy. | 05-05-2016 |
20160115177 | HIGHLY POTENT INHIBITORS OF PORCUPINE - The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis. | 04-28-2016 |
20160109460 | Methods And Compositions For Determining Fortilin Levels - Certain embodiments are directed to method of measuring fortilin in a serum sample as a biomarker of in vivo apoptosis, which can be utilized to noninvasively assess the status of in vivo apoptosis in a subject. | 04-21-2016 |
20160095831 | USE OF HYDROGEN SULFIDE SYNTHESIS INHIBITORS FOR CANCER THERAPY - In certain aspects the methods comprise administering an inhibitor of hydrogen sulfide biosynthesis, a cystathionine-β-synthase (CBS) inhibitor, or a hydrogen sulfide neutralizing agent to a patient having a cancer associated with elevated production of hydrogen sulfide. | 04-07-2016 |
20160077093 | METHODS FOR DETECTING EHRLICHIA INFECTION - The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against | 03-17-2016 |
20160067333 | GENERATING PEPTOID VACCINES - The present invention provides for methods of identifying peptoid mimetics that will mimic B cell epitopes when delivered as vaccine compositions. One aspects of the invention is the use of monoclonal antibody that is broadly protective to select the mimetics, thereby identifying an epitope from a pathogen or other disease-causing agent that will be common among most or all variants of that pathogen or agent. | 03-10-2016 |
20160066934 | DEVICES AND METHODS FOR REMOVAL OF CALCULUS - Devices and methods for removal of calculus (including for example, kidney stones) are disclosed. In an embodiment, a device for removal of kidney stones includes a substantially sealable pouch that can be inserted into the kidney for capturing a kidney stone. The pouch is also designed to permit fragmentation of the kidney stone inside the pouch, while preventing kidney stone fragments from escaping from the pouch. As a result, the likelihood of dispersing stone fragments during fragmentation of a large stone is greatly lessened. | 03-10-2016 |
20160058779 | METHODS FOR TREATING VIRAL INFECTIONS USING HYDROGEN SULFIDE DONORS - Certain embodiments are directed to methods of treating respiratory infection by administering an H | 03-03-2016 |
20160032011 | HER3 SPECIFIC MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE - Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. | 02-04-2016 |
20160031803 | OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCERS - The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided. | 02-04-2016 |
20160030457 | TUMOR-SELECTIVE COMBINATION THERAPY - The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1. | 02-04-2016 |
20160024592 | SINGLE-CELL ANALYSIS AS A SENSITIVE AND SPECIFIC METHOD FOR EARLY PROSTATE CANCER DETECTION - Certain embodiments are directed to methods of measuring single cell levels of biomarkers associated with prostate cancer. | 01-28-2016 |
20160024207 | MONOCLONAL ANTIBODIES TARGETING EPCAM FOR DETECTION OF PROSTATE CANCER LYMPH NODE METASTASES - Embodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via surgical field near-infrared fluorescence (NIRF) imaging following (in the case of dual labeled agents) nuclear imaging for general localization. Currently, nodal staging of most cancers is performed following lymph node (LN) biopsy and dissection for subsequent pathological examination. | 01-28-2016 |
20160015636 | NOVEL LOW DENSITY LIPOPROTEIN NANOCARRIERS FOR TARGETED DELIVERY OF OMEGA-3 POLYUNSATURATED FATTY ACIDS TO CANCER - The presently disclosed LDL nanocarrier is an effective and appropriate transporter for DHA in biological systems. The LDL-DHA nanoparticle was shown to be preferentially cytotoxic to malignant liver cells. LDL-DHA nanoparticles show great promise as an anti-cancer agent. | 01-21-2016 |
20150374696 | WNT PROTEIN SIGNALLING INHIBITORS - The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis. | 12-31-2015 |
20150360201 | METAL-ORGANIC FRAMEWORKS FOR SELECTIVE SEPARATIONS - Disclosed herein are metal-organic frameworks (MOF) and uses thereof, including those comprising a repeat unit of the formula [Cu3(L1)2(H20)3] or [Cu3(L2)2(H20)3], wherein L1 is a ligand of the formula: (structurally represented), and where L2 is a ligand of the formula: (structurally represented). These are useful for many applications, including in the purification of hydrogen gas from production byproducts CH4 and C02, sensing, heterogeneous catalysis, drug delivery, lithium sulfide battery, membrane and analytical devices. | 12-17-2015 |
20150355172 | ADP-RIBOSE DETECTION REAGENTS - The present disclosure described fusion proteins between ADP-ribose binding domains and antibody Fc domains. This new class of reagents has considerable value as detection agents in assays designed at examining the biology of ADP-ribose. | 12-10-2015 |
20150328192 | RAPAMYCIN ANALOGS TARGETING PROTEASOME FUNCTION IN THE TREATMENT OF CANCER - The invention provides for treatment of cancers using a rapamycin analog, optionally including bortezomib. In particular, the invention addresses the treatment of bortezomib-resistant cancers using seco-rapamycin and optionally a second proteasome inhibitor. This invention relates to oncology and medicine, and more particularly to treatment of cancer. In particular, rapamycin analogs such as seco-rapamycin may be used advantageously to target the proteasome in cancer cells, optionally in conjunction with proteasome inhibitors such as bortezomib. | 11-19-2015 |
20150322143 | ANTIBODIES THAT BIND AMYLOID OLIGOMERS - Embodiments of the invention are directed to compositions and methods related to immunogenic compositions comprising the amino acid sequence of SEQ ID NO:1 and amyloid oligomer specific antibodies that specifically bind an oligomer comprising such a peptide. | 11-12-2015 |
20150307847 | CARDIAC REPAIR BY REPROGRAMMING OF CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES - The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair. | 10-29-2015 |
20150306253 | DUAL EMISSIVE METAL NANOPARTICLES AS RATIOMETRIC PH INDICATORS - In some aspects, the present disclosure provides a dual emissive pH response noble metal nanoparticle which produces a ratiometric fluorescence signal based upon changes in the pH. In another aspect, the noble metal nanoparticle may be used in bioimaging applications as well as to detect in vivo changes of pH. | 10-29-2015 |
20150292041 | METHODS AND COMPOSITIONS FOR IDENTIFYING ENTEROVIRUS - Certain embodiments of the invention include, but are not limited to PCR primer pairs, sequencing primers, and/or associated thermocycling protocols targeting a region identified by the inventors within the 5′ untranslated region of enteroviruses for the purpose of identifying, subtyping, and/or classifying of virus in samples using nucleic acid sequencing. The sequencing procedures can use nucleic acid templates, such as cDNA or PCR amplicons, as a template for sequencing in medium to high throughput format that is cost effective and easily deployed to other clinical microbiology laboratories. | 10-15-2015 |
20150276836 | METHODS AND DEVICES FOR MEASURING CONDUCTIVITY OF FLUIDS - A sensor for detecting the breakthrough of hardness in a water softener measures a change in the conductivity of elongated cation-exchange material in contact with the treated water. | 10-01-2015 |
20150273038 | COMPOSITIONS AND METHODS FOR ENTEROHEMORRHAGIC ESCHERICHIA COLI (EHEC)VACCINATION - Certain embodiments are directed to compositions comprising EHEC-specific antigens. In certain aspects EHEC O157:H7-specific antigen(s) are used as components of immunogenic compositions and vaccines. | 10-01-2015 |
20150266960 | ANTIBODIES WITH ENGINEERED IGG FC DOMAINS - Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided. | 09-24-2015 |
20150250788 | 2,3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES FOR USE IN THE TREATMENT OF VIRAL INFECTIONS - Use of 2,3-dihydroquinazolin-4(1H)-one cyclic derivatives of formula (I) for the treatment of infection with viruses entering cells by endocytosis, especially filovirus such as Ebolavirus. | 09-10-2015 |
20150246174 | NANOCHANNELED DEVICE AND RELATED METHODS - A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate. | 09-03-2015 |
20150237870 | INHIBITION OF BIOFILM FORMATION WITH GENETICALLY ENGINEERED BACTERIOPHAGES - Embodiments are directed to engineered bacteriophages that produce polypeptides that interfere with or quench quorum sensing. In certain aspects the quorum quenching enzyme AiiA has a broad specificity for degrading substrates, small signal molecule acyl homoserine factories (AHL) that initiates the quorum sensing pathway with global impact for diverse bacteria in biofilm. Certain embodiments are directed to the engineered T7aiiA phage that effectively degraded AHL from diverse bacteria and inhibited formation of the mixed species biofilms containing | 08-27-2015 |
20150218239 | FCRN Antagonists and Methods of Use - Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions. | 08-06-2015 |
20150211007 | SELECTIVE INHIBITION OF POLYGLUTAMINE PROTEIN EXPRESSION - The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntington using nucleic acid analogs. Peptide nucleic acids and locked nucleic acids are particularly useful analogs. | 07-30-2015 |
20150175975 | Alphavirus Compositions and Methods of Use - Embodiments are directed compositions related to Eilat virus and uses thereof. Certain aspects are directed to the detection of non-Eilat entities using a chimeric Eilat alphavirus as a capture agent. | 06-25-2015 |
20150157633 | WNT PROTEIN SIGNALLING INHIBITORS - The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis. | 06-11-2015 |
20150152420 | COMPOUNDS AND METHODS FOR ALTERING RSV REPLICATION RATE - Provided herein are methods for altering respiratory syncytial virus (RSV) replication in a cell using oligonucleotides derived from tRNAs, also referred to as tRFs (tRNA-derived RNA Fragments). The oligonucleotides may be used to decrease or increase replication of RSV. Also provided herein are methods for treating a subject having or at risk of having an RSV infection, and animal models for evaluating viral and host factors in RSV pathogenesis. | 06-04-2015 |
20150110809 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) - Embodiments of the invention are directed to compounds that inhibit an activity of EP AC proteins and methods of using the same. The inventors have developed a sensitive and robust high throughput screening (HTS) assay for the purpose of identifying EPAC specific inhibitors (Tsalkova et al. (2012) PLOS ONE 7 (1):e30441). | 04-23-2015 |
20150100057 | FOOT, ANKLE AND LOWER EXTREMITY COMPRESSION AND FIXATION SYSTEM AND RELATED USES - In general, various embodiments of the present invention comprise an external fixation device, an internal fixation device, and a lower extremity stabilizer. The external fixation device is connected to the lower extremity stabilizer and the external fixation device is adjustably connected to the internal fixation device. The internal fixation device is capable of being attached to at least one bone in a patient's foot, ankle, and/or lower extremity. The system is capable of simultaneously compressing and stabilizing at least one bone for treating Charcot neuroarthropathy, fractures, revisional foot and ankle surgery including but not limited to malunions, nonunions, delayed unions, fibrous unions, avascular necrosis, resected osteomyelitis, incorporated autogenous and/or allogenic bone grafts for arthrodesis procedures, pseudoarthrosis and bones with decreased mineral density and cortical stiffness, and/or the like for any reconstructive and/or elective foot and ankle surgery where a compression arthrodesis is needed. The external fixation device and/or lower extremity stabilizer can be removed after a certain period of time, leaving the internal fixation system within the body for prolonged stabilization and maintenance of the arthrodesis site(s). | 04-09-2015 |
20150094343 | ORALLY BIOAVAILABLE CAFFEIC ACID RELATED ANTICANCER DRUGS - The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines. | 04-02-2015 |
20150087693 | MICRO-RNAS INVOLVED IN MACULAR DEGENERATION - The present invention relates to the involvement of miR function in the development of age-related macular degeneration (AMD). It is shown that miR-23, miR-24 and/or miR-27 are involved in pathologic neovascularization in AMD, and that agonism (miR-24) and inhibition (miR23/27) of the function of these molecules blocks events contributing to development and progression of disease. | 03-26-2015 |
20150061180 | SUPERFINE FIBER CREATING SPINNERET AND USES THEREOF - Apparatuses and methods for the production of superfine fibers. | 03-05-2015 |
20150057248 | BIVALENT AMPA RECEPTOR POSITIVE ALLOSTERIC MODULATORS - Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors. | 02-26-2015 |
20150023915 | TREATMENT FOR MELANOMA - The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include MEK inhibitors combination with cardiac glycosides. | 01-22-2015 |
20150011509 | COMPOUNDS AND ANTI-TUMOR NQO1 SUBSTRATES - Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy. | 01-08-2015 |
20150011507 | COMPOSITIONS COMPRISING LECITHIN OILS AND NSAIDS FOR PROTECTING THE GASTROINTESTINAL TRACT AND PROVIDING ENHANCED THERAPEUTIC ACTIVITY - A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration. | 01-08-2015 |
20140378558 | BIOMARKER FOR DETECTING CANCER - Methods for detecting colorectal cancer in a subject by detection of a galactose-containing 40 kDa molecule in a serum sample from the subject. Methods for quantifying the amount of a galactose-containing molecule in a serum sample are also provided. | 12-25-2014 |
20140377288 | COMPOSITIONS AND METHODS RELATED TO DNA DAMAGE REPAIR - The present invention provides compositions and methods for treating a cancer associated with elevated expression and/or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5. In some embodiments, the present invention provides compositions and methods for identifying elevated expression or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5. | 12-25-2014 |
20140371834 | GASTROINTESTINAL ELECTRICAL STIMULATION - The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract. | 12-18-2014 |
20140371132 | CODON SIGNATURE FOR NEUROMYELITIS OPTICA - The present invention provides for the diagnosis and prediction of neuromyelitis optica (NMO) in subject utilizing a unique a codon signature in B cells that has now been associated with NMO and not with any other autoimmune disease. More particularly, the method may comprise the steps of (a) providing a 10 B-cell containing sample from a subject, or DNA or RNA isolated therefrom; (b) determining the VH1 and/or VH4 structure of VH1NH4-expressing B-cells from said subject, (c) determining the mutational frequency VH1 and/or VH4 genes; (d) identifying the presence or absence of a codon signature associated with NMO or risk of NMO; and (e) selecting patients exhibiting said codon signature. | 12-18-2014 |
20140364467 | CHEMICAL INDUCERS OF NEUROGENESIS - The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy. | 12-11-2014 |
20140357608 | TACCALONOLIDE MICROTUBULE STABILIZERS - The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents. | 12-04-2014 |
20140356285 | COMPOSITIONS AND METHODS RELATED TO TISSUE TARGETING - Systems and reagents for identification, characterization and/or targeting of particular tissue or cell markers are disclosed. Methods and compositions for in vivo and in vitro targeting of particular targets are also disclosed. Peptides are employed for targeted delivery of therapeutic or imaging agents. | 12-04-2014 |
20140348853 | METHODS OF TREATING RICKETTSIA USING EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) INHIBITORS - Embodiments of the invention are directed to compounds that inhibit an activity of EPAC proteins and methods of using the same. | 11-27-2014 |
20140342466 | Nanoporous substrates for analytical methods - Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range. | 11-20-2014 |
20140336375 | ALLOSTERIC MODULATORS OF 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT2CR) - The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases. | 11-13-2014 |
20140323647 | SOFTENING MATERIALS BASED ON THIOL-ENE COPOLYMERS - Embodiments of the invention are directed to softening amorphous polymeric materials based on a combination of thiol, acrylate, ene and epoxy monomers. These materials can soften to the modulus of tissue, have a sharp transition and are highly tunable. The materials have a glassy modulus of 1-7 GPa and exhibit a rubbery plateau in modulus that can range from 100 MPa down to as low as 0.03 MPa, which is at or below the modulus of tissue. They have potential uses as materials for near net shape processing such as casting, stereolithography, reaction injection molding, fused deposition molding and various other forms of 3D printing. | 10-30-2014 |
20140323568 | OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCERS - The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided. | 10-30-2014 |
20140319734 | REAL TIME MANUFACTURING OF SOFTENING POLYMERS - Embodiments of the invention is directed to a manufacturing process to mold and cast custom softening polymers into complex shaped devices, said process comprising the steps of: creating a 3D mold or shell; injecting the shell with a polymer or pre-polymer; cooling or curing the polymer in a short period of time; and forming a device. | 10-30-2014 |
20140315966 | Isoxazole Treatments for Diabetes - The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of diabetes. | 10-23-2014 |
20140315754 | METHODS AND COMPOSITIONS FOR ASSESSING AND TREATING CANCER - Embodiments are directed to methods and compositions for determining the level of DCLK1-S in a sample and treating a subject having elevated levels of DCLK1-S. | 10-23-2014 |
20140303239 | TELOMERASE MEDIATED TELOMERE ALTERING COMPOUNDS - The present disclosure is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogs thereof for the treatment of cancer and other hyperproliferative diseases. The described compounds can be converted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells. | 10-09-2014 |
20140296134 | METHODS AND USES FOR METABOLIC PROFILING FOR CLOSTRIDIUM DIFFICILE INFECTION - Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample. | 10-02-2014 |
20140291590 | HIGH PERFORMANCE LIGHT EMITTING DEVICES FROM IONIC TRANSITION METAL COMPLEXES - Embodiments of the invention are directed to single layer light-emitting electrochemical cells that are enhanced by ionic additives, and methods of manufacture. These devices exhibit high efficiency, rapid response and long lifetimes. | 10-02-2014 |
20140276611 | Trapping Sheaths and Guide Catheters - Introducer sheaths and (e.g., guide) catheters with inflatable trapping elements for trapping and/or stabilizing devices (e.g., guidewires, catheters, and/or the like) in a primary lumen of the sheath or catheter. Such sheaths and catheters may be configured for endovascular, endoscopic, laparoscopic, and/or urological procedures. | 09-18-2014 |
20140275189 | Methods for Modulating Bacterial Virulence and Related Compounds - The present invention relates to compounds and methods for the treatment of bacterial infections. The compounds and methods involve the disruption of the QseC signaling pathway which modulates the virulence of some bacteria. This methodology for treatment of bacterial infections reduces evolutionary pressure to develop resistance because the bacteria are not killed in the process. | 09-18-2014 |
20140273026 | Methods for Detecting Ehrlichia Infection - The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against | 09-18-2014 |
20140263278 | SOLAR SELECTIVE MULTILAYER COATING - The present invention provides a method for making a highly efficient and inexpensive solar selective coating. Coating consists of various carbon nanotube sheets composite layers, each performing a specific function by incorporating functional materials and components with proper structure. Joule heating of the described solar selective coating allows for efficient functionality even when solar energy is not available. | 09-18-2014 |
20140249152 | TREATMENT FOR GASTROPARESIS USING SEPIAPTERIN - The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor. | 09-04-2014 |
20140243738 | Fluid Balance Monitoring System with Fluid Infusion Pump for Medical Treatment - Novel fluid delivery systems are disclosed to improve the delivery of bio-compatible fluids to a patient. The systems can include a housing having a bladder pressurized by a pressurization unit so that fluid flow rate can be controlled, changed and/or monitored. The systems can also include a scale and/or a flow control unit. | 08-28-2014 |
20140243258 | METHODS AND COMPOSITIONS FOR TARGETING ADIPOSE CELLS IN MAMMALS - Methods and compositions are presented for use in diagnostic, imaging or targeting of therapeutic agents to treat obesity/adiposity-associated disorders, where such as compositions and methods identify and use peptides to selectively target adipose tissue stromal cells in mammals, both in vitro and in vivo. | 08-28-2014 |
20140235546 | Novel Peptide Inhibitors of Serotonin 5-HT2c Receptors:PTEN Interaction - The 5-HT 2C receptor is implicated in feeding, obesity, palatable food reward, metabolic disorders, drug addiction, anxiety, stress sensitivity, and depression. Embodiments of the invention are directed to modulation of the 5 -HT 2cR. Certain aspects are directed to therapies for the above referenced conditions. In certain aspects, therapeutic agents are identified that disrupt the 5-HT2cR:PTEN complex activating 5-HT2CR signaling. In certain aspects the complex is disrupted by a disrupter. The disrupter can be a peptide that displaces PTEN from the 5-HT 2cR:PTEN complex or inhibits the formation of the complex. | 08-21-2014 |
20140221724 | REAL-TIME IN VIVO RADIATION DOSIMETRY USING SCINTILLATION DETECTOR - Apparatus and methods for measuring radiation levels in vivo in real time. Apparatus and methods include a scintillating material coupled to a retention member. | 08-07-2014 |
20140220603 | COMPOSITIONS AND METHODS FOR DETECTING MICROBIAL INFECTIONS - Provided herein are vaccine compositions for control of | 08-07-2014 |
20140219097 | METHOD AND APPARATUS FOR CONGESTION-AWARE ROUTING IN A COMPUTER INTERCONNECTION NETWORK - The present disclosure relates to an example of a method for a first router to adaptively determine status within a network. The network may include the first router, a second router and a third router. The method for the first router may comprise determining status information regarding the second router located in the network, and transmitting the status information to the third router located in the network. The second router and the third router may be indirectly coupled to one another. | 08-07-2014 |
20140206693 | COMPOSITIONS AND METHODS FOR TREATING COLON CANCER - Certain embodiments are directed to methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway using an aldose reductase specific inhibitor. | 07-24-2014 |
20140195094 | Microcrawler and Conveyor Robots, Controllers, Systems, and Methods - Robots, controllers, systems, and methods for microcrawler robots (e.g., with stick-slip gaited locomotion and/or with power multiplexing between actuators). | 07-10-2014 |
20140194266 | Stretching Machine - Certain embodiments are directed to a machine that stabilizes the lumbar spine in anatomic position while stretching the hamstrings, tensor fascia lata, and lliotibial (IT) band. | 07-10-2014 |
20140193837 | LUMINESCENT NANOPARTICLE COMPOSITIONS - A composition is disclosed which is capable of being used for detection, comprising a noble metal nanoparticle. The inventive compositions exhibit little interaction with serum proteins while exhibiting pH-dependent adsorption onto live cell membranes. The nanoparticles of the claimed invention are capable of interacting with cell membranes, which in turn permits the advantages of nanoparticle bio-imaging to be extended to many pH dependent biological processes such as targeting acidic tumor microenvironment. | 07-10-2014 |
20140193009 | METHOD AND SYSTEM FOR ENHANCING THE INTELLIGIBILITY OF SOUNDS RELATIVE TO BACKGROUND NOISE - A novel dual-microphone speech enhancement technique is proposed that utilizes the coherence function between input signals as a criterion for noise reduction. The technique is based on certain assumptions regarding the spatial properties of the target and noise signals and can be applied to arrays with closely spaced microphones, where noise captured by sensors is highly correlated (e.g., inside a mildly reverberant environment). The proposed algorithm is simple to implement and requires no estimation of noise statistics. In addition, it offers the advantage of coping with situations in which multiple interfering sources located at different azimuths might be present. | 07-10-2014 |
20140180251 | NANOCHANNELED DEVICE AND RELATED METHODS - A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate. | 06-26-2014 |
20140162173 | SULFONATED PERFLUOROCYCLOPENTENYL POLYMERS AND USES THEREOF - An aspect of the invention is directed to a polymer comprising a sulfonated perfluorocyclopentyl compound. Another aspect of the invention is directed to a sulfonated copolymer comprising one or more sulfonated polymers. A further aspect of the invention is directed to membranes prepared from the polymers of the claimed invention. | 06-12-2014 |
20140155460 | MICRO-RNA'S THAT REGULATE MUSCLE CELLS - The present invention describes microRNAs that regulate the differentiation, proliferation and death of cardiac and skeletal muscles cells. These molecules represent unique targets in the developmental pathways of muscle cells. They also can be used as active agents to induce differentiation in progenitor cells, and their down-regulation permits the maintenance and expansion of progenitor cell populations. | 06-05-2014 |
20140150859 | IONICALLY RECONFIGURABLE ORGANIC PHOTOVOLTAIC AND PHOTONIC DEVICES WITH TUNABLE COMMON ELECTRODE - The present invention is directed to a novel type of monolithic hybrid technology. The invention is directed to photonic devices with a minimum of three (3) electrodes and by an inventive process for incorporating mobile ions into organic components of high performance organic photovoltaic (OPV) devices, organic photodetectors and other hybrid photonic devices (such as tandems of OPV), through a novel unique device architecture of a hybrid “Ionic-NT-OPV” structure, in which the ionic components are separated from the OPV by a common nanoporous charge collecting electrode (symbolically depicted as a nanotube: NT), permeable to ions of ionic component inside an inter-connected microchamber. | 06-05-2014 |
20140142605 | TISSUE DISSECTOR AND INCISOR - The device described herein facilitates interventional medical procedures, reduces the formation of skin tag, and increases the safety of such procedures relative to the operator and patient. | 05-22-2014 |
20140141390 | DUAL-CURE DENTAL RESINS AND ADHESIVES WITH INCREASED CURE AND COLOR-STABILITY AND LOW COLOR - Various embodiments of the present invention generally relate to a light-cure and dual-cure resin that have low color and is color stable over conventional light, self and dual-cured resins. Additionally, the light-cure resin has enhanced degree of cure over conventional light-cure resins. Finally, due to the low color and enhanced color stability of the dual-cure resins, their inherent property of having lower shrinkage stress as compared to light-cure resins can now be utilized in various dental applications and other resin applications. | 05-22-2014 |
20140128449 | OLIGONUCLEOTIDE MODULATION OF SPLICING - The present invention relates to the selective modulation of pre-mRNA splicing, in particular, for that involving alternative splicing in disease-related proteins such as those involved in Duschenne's Muscular Dystropy and Spinal Muscular Atrophy. | 05-08-2014 |
20140105933 | METHODS FOR ASSESSING CANCER RECURRENCE - Certain embodiments are directed to methods of identifying a subject having a higher risk of prostate cancer recurrence. The methods can include the step of measuring levels of one or more of FLIP, transcription factor Sp1, and transcription factor Sp3 in a prostate sample from the subject, wherein elevated levels of FLIP, transcription factor Sp1, and transcription factor Sp3 identify a subject as high risk for prostate cancer recurrence. | 04-17-2014 |
20140099256 | RADIOACTIVE LUMINESCENT NANOPARTICLE COMPOSITIONS - An embodiment of the invention is directed to a composition comprising a luminescent noble metal nanoparticle, wherein the surface of the noble metal nanoparticle is coated with a ligand, and wherein the noble metal nanoparticle is about 2 nm to 5 nm in diameter and further wherein a portion of the noble metal is present as its radioactive isotope. In an embodiment of the invention, the radioactive isotope is present at a concentration of up to 2% w/w of the noble metal. | 04-10-2014 |
20140093477 | MODULATING BACTERIAL MAM POLYPEPTIDES IN PATHOGENIC DISEASE - The disclosure relates to methods and compositions for preventing or inhibiting pathogenic bacterial infections in a subject caused by pathogenic bacteria expressing a multivalent adhesion molecule (MAM) polypeptide by administering to a subject a composition comprising a MAM polypeptide or a non-pathogenic bacterium expressing a MAM polypeptide, or a combination thereof. | 04-03-2014 |
20140087509 | MEMS-BASED CANTILEVER ENERGY HARVESTER - The claimed invention is directed to integrated energy-harvesting piezoelectric cantilevers. The cantilevers are fabricated using sol-gel processing using a sacrificial poly-Si seeding layer. Improvements in film microstructure and electrical properties are realized by introducing a poly-Si seeding layer and by optimizing the poling process. | 03-27-2014 |
20140080772 | TREATMENTS FOR MELANOMA - The present invention relates to mono- and combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include RO 31-8220, bafetinib, and cardiac glycosides. | 03-20-2014 |
20140073652 | Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof - Provided herein are methods and compounds for post-translational regulation of cytochrome P450 46A1 (CYP46A1) enzyme activity in the brain and retina. Also, a method for identifying a potential regulator of a CYP46A1 enzyme using crystal structures of the enzyme and a subsequent method for screening for a regulatory activity in the presence of CYP46A1 enzyme are provided. In addition, the regulator compounds that either inhibit or stimulate cholesterol hydroxylation by the CYP46A1 enzyme are provided. Further provided is a method of treating a pathoneurological condition associated with increased cholesterol levels in the brain and retina using the stimulatory compounds. | 03-13-2014 |
20140066392 | COMBINATION TREATMENTS FOR MELANOMA - The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include BRAF inhibitors such as PLX 4720 and PLX 4734 in combination with RO 31-8220, bafetinib or cardiac glycosides. | 03-06-2014 |
20140058190 | SYSTEM AND METHOD FOR CONTROLLING PUMP - Systems and methods including a motor or electromagnets to control the movement of one or more pistons in a pumping chamber. The pumping chamber may include a pump inlet and a pump outlet in fluid communication with the pumping chamber. Surfaces on a piston or pumping chamber may include hydrodynamic bearing surfaces. | 02-27-2014 |
20140056938 | Alphavirus Compositions and Methods of Use - Embodiments are directed compositions related to Eilat virus and uses thereof. | 02-27-2014 |
20140051906 | CHRONIC ELECTROACCUPUNCTURE USING IMPLANTED ELECTRODES - A method of providing an implantable stimulation system to achieve chronic or permanent electrical stimulation of acupuncture points to treat a variety of chronic disorders. | 02-20-2014 |
20140051751 | ENVIRONMENT-FRIENDLY ANTIFOULANTS FOR THE PREVENTION OF BIOFOULING - Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize compounds having a Lipophilic-Amide-Spacer-ElectroNegative (“LASEN”) structural motif, such as capsaicin, and compounds having a TetraHydroCannibinoid (“THC”) structural motif. The antifoulant compositions are non-toxic, and effective. | 02-20-2014 |
20140045799 | INOSITOL HEXAKISPHOSPHATE ANALOGS AND USES THEREOF - Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat a | 02-13-2014 |
20140023590 | NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF - Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH | 01-23-2014 |
20140018446 | Serum Biomarker Screen for the Diagnosis of Clinical and Preclinical Alzheimer's Disease - Certain embodiments are directed to methods of identifying dementia in subjects comprising, measuring serum levels of one or more of interferon gamma, IL-10, IL-12p40, IL-13, alpha 2 macroglobulin, beta 2 microglobulin, pancreatic polypeptide, prolactin, stem cell factor, thrombopoietin, and Von Willebrand Factor and identifying a subject as having dementia if the levels of the biomarkers is increased. | 01-16-2014 |
20140010841 | Attenuated Recombinant Alphaviruses Incapable of Replicating in Mosquitoes and Uses Thereof - The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions. | 01-09-2014 |
20130331426 | pH-SENSITIVE COMPOSITIONS FOR DELIVERY OF BETA LAPACHONE AND METHODS OF USE - Disclosed herein are compounds comprising a polymer conjugated with a pH-sensitive prodrug of beta-lapachone, wherein the compound is capable of forming a micelle, and wherein the pH-sensitive prodrug comprises a pH-sensitive linker selected from the group consisting of: an aryl imine and an aliphatic imine. Also provided are micelles comprised of such polymer-prodrug conjugates. Further provided are methods for treating cancer with the micelles. | 12-12-2013 |
20130302245 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS - Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent. | 11-14-2013 |
20130295580 | ORAL CANCER POINT OF CARE DIAGNOSTICS - A point of care diagnostic test, device and disposables for determining a patient risk for oral cancer in the same visit that a sample is collected. | 11-07-2013 |
20130274638 | METHODS AND APPARATUS FOR LOWERING INTRACRANIAL AND INTRASPINAL CORD PRESSURE - Apparatus and methods are provided for applying negative pressure to tissues of a patient that are transmitted to the vertebral venous system of the patient and thereby lowering intracranial pressure. Intracranial pressure is thus lowered easily without increasing the work of breathing, without needing to be intubated, and without breathing through a valve in patients with elevated increased intracranial pressure. | 10-17-2013 |
20130260503 | Methods and Apparatuses for Integrated Packaging of Microelectromechanical Devices - Microelectromechanical systems (MEMS) packages, packaged MEMS devices, and methods for making the same are disclosed. The method may include forming a chamber sacrificial layer above an insulating layer that is coupled to a wafer. The method further may include forming a packaging layer above the chamber sacrificial layer. The method additionally may include forming one or more openings through the packaging layer. The method also may include removing the chamber sacrificial layer through the one or more openings. The method may include forming a sealing layer above the packaging layer such that the sealing layer substantially seals the one or more openings to form a hermetic cavity. | 10-03-2013 |
20130253046 | METHODS OF TREATING CANCER COMPRISING TARGETING NQO1 - Disclosed herein are methods for determining whether an individual with cancer is suitable for a treatment with an NQO1 bioactivatable drug, predicting responsiveness of an individual with cancer to a treatment with an NQO1 bioactivatable drug, and treating an individual with cancer with an NQO1 bioactivatable drug composition. | 09-26-2013 |
20130243815 | INHIBITORS OF DSRNA-DEPENDENT PROTEIN KINASE (PKR) AS ENHANCERS OF BUNYAVIRUS LIVE-ATTENUATED VACCINES - Certain embodiments of the invention are directed to methods and compositions for inhibiting dsRNA-dependent protein kinase (PKR) and augmenting the immunogenicity of Bunyavirus live-attenuated vaccines. | 09-19-2013 |
20130240847 | MONOLITHIC PARALLEL MULTIJUNCTION OLED WITH INDEPENDENT TUNABLE COLOR EMISSION - A tandem organic light emitting diode (OLED) device comprised of multiple stacked single OLEDs electrically connected in parallel via transparent interlayer is recited herein. Transparent interlayers are coated by charge injection layers in order to enhance the charge injection efficiency and decrease the operation voltage. Transparent nanomaterials, such as carbon nanotube sheets (or graphene, graphene ribbons and similar conductive transparent nano-carbon forms) are used as Interlayers or outer electrodes. Furthermore, functionalization of carbon nanotubes inter layers by n-doping (or p-doping) converts them into common cathode (or common anode), further decreasing operation voltage of tandem. The development of these alternative interconnecting layers comprised of nanomaterials simplifies the process and may be combined with traditional OLED devices. In addition, novel architectures are enabled that allow the parallel connection of the stacked OLEDs into monolithic multi-junction OLED tandems. | 09-19-2013 |
20130240483 | NANOCHANNELED DEVICE AND RELATED METHODS - A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel. | 09-19-2013 |
20130240027 | MULTIJUNCTION HYBRID SOLAR CELL WITH PARALLEL CONNECTION AND NANOMATERIAL CHARGE COLLECTING INTERLAYERS - A tandem (or multijunction) hybrid photovoltaic device (PV) device comprised of multiple stacked single PVs connected in parallel with each other is described herein. Furthermore, nanomaterials are used as transparent charge collecting electrodes that allow both parallel connection via anode interlayer and also “inverted parallel” connection via cathode type interlayer of different types of solar cells. Carbon nanotube sheets are used as a convenient example for the charge collecting electrodes. The development of these alternative interconnecting layers simplifies the process and may be also used for combined organic PVs with traditional inorganic PVs and Dye Sensitized Solar Cells (DSSC). In addition, novel architectures are enabled that allow the parallel connection of the stacked PVs into monolithic multi-junction PV tandems. This new monolithic parallel connection architecture enables enhanced absorption of the solar spectrum and results in increased power conversions efficiency. Moreover, architectures where cells are stacked monolithically using a series connection can be coupled with cells to create mixed series and parallel connected tandem cells. | 09-19-2013 |
20130224371 | Method of Manufacturing Electrodes using Carbon nanotube Sheets - Growing spin-capable multi-walled carbon nanotube (MWCNT) forests in a repeatable fashion will become possible through understanding the critical factors affecting the forest growth. Here we show that the spinning capability depends on the alignment of adjacent MWCNTs in the forest which in turn results from the synergistic combination of a high areal density of MWCNTs and short distance between the MWCNTs. This can be realized by starting with both the proper Fe nanoparticle size and density which strongly depend on the sheet resistance of the catalyst film. Simple measurement of the sheet resistance can allow one to reliably predict the growth of spin-capable forests. The properties of pulled MWCNTs sheets reflect that there is a relationship between their electrical resistance and optical transmittance. Overlaying either 3, 5, or 10 sheets pulled out from a single forest produces much more repeatable characteristics. | 08-29-2013 |
20130224117 | LATENT VARIABLE APPROACH TO THE IDENTIFICATION AND/OR DIAGNOSIS OF COGNITIVE DISORDERS AND/OR BEHAVIORS AND THEIR ENDOPHENOTYPES - Certain embodiments are directed to methods of distinguish “target-relevant” variance in observed clinical and physiological measures from the variance in observed data that is unrelated to any target process. | 08-29-2013 |
20130216482 | METHODS AND COMPOSITIONS FOR NON-INVASIVE, DYNAMIC IMAGING OF INTESTINAL MOTILITY - Described are methods and composition for use in non-invasive imaging of intestinal structure and function. These methods can be used to identify, diagnose, assess, monitor and direct therapies for gastrointestinal diseases and disorders. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye excreted in bile into the intestinal tract to provide quantitative information regarding intestinal propulsion and function. | 08-22-2013 |
20130212975 | METHOD FOR AN ICE BUILDUP INHIBITOR - An ice buildup inhibitor is disclosed useful for preventing ice damming, in particular in conjunction with the use of a closed gutter. Heat escape through a roof made warm snow pack, causing it to melt and flow down toward the gutter. After moving away from the heated roof, the water may re-freeze and form an ice dam. In the ice buildup inhibitor may be configured to warm in the closed gutter, thereby preventing the formation of an ice dam. They ice buildup inhibitor may be configured to be easily installed onto an existing closed gutter, enabling responsive installation on only those homes experiencing ice damming. | 08-22-2013 |
20130210157 | Zn3(BDC)3[Cu(SalPycy)] AND Zn3(CDC)3[Cu(SalPycy)] - ENANTIOPURE MIXED METAL-ORGANIC FRAMEWORKS FOR SELECTIVE SEPARATIONS AND ENANTIOSELECTIVE RECOGNITION - Disclosed herein are mixed metal-organic frameworks, Zn | 08-15-2013 |
20130200921 | DATA TAG CONTROL FOR QUANTUM-DOT CELLULAR AUTOMATA - The present disclosure relates to methods and systems for data tag control for quantum dot cellular automata (QCA). An example method includes receiving data, associating a data tag with the data, communicating the data tag along a first wire-like element to a local tag decoder, reading instructions from the data tag using the local tag decoder, communicating the instructions to a processing element, communicating the data along a second wire-like element to the processing element, and processing the data with the processing element according to the instructions. A length of the first wire-like elements and a length of the second wire-like element are approximately the same such that communication of the instructions and the data to the processing element are synchronized. | 08-08-2013 |
20130197295 | TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY - Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heat energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy. | 08-01-2013 |
20130195814 | TISSUE-SPECIFIC DIFFERENTIATION MATRICES AND USES THEREOF - In some aspects, this invention provides a method of making a bone marrow-derived tissue-specific stem cell proliferation, expansion, isolation and rejuvenation extracellular matrix. In other aspects, this invention provides a method of making a tissue-specific fibroblast-derived stem cell differentiation extracellular matrix. Also provided are methods of using such a cell-derived preservation or differentiation matrices to induce tissue-specific differentiation of pluripotent cells, repair damaged tissue, and treat a subject having a physiologic deficiency using the same. | 08-01-2013 |
20130184345 | OLIGO-BENZAMIDE COMPOUNDS FOR USE IN TREATING CANCERS - The present invention provides bis- and tris-benzamide compounds in the treatment of breast, brain and ovarian cancers. | 07-18-2013 |
20130178835 | IDENTIFYING SYNTHETIC LIGANDS THAT BIND T-CELLS FROM PATIENTS HAVING AN AUTOIMMUNE DISEASE - The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations. | 07-11-2013 |
20130178506 | ISOXAZOLE TREATMENTS FOR DIABETES - The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of diabetes. | 07-11-2013 |
20130178370 | PROTEOMIC IDENTIFICATION OF ANTIBODIES - Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects, methods for determining amino acid sequences of serum antibody CDR3 and abundancy levels are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and the frequency thereof in biological samples are provided. Furthermore, the invention provides methods for identification and generation of antibodies or antigen-binding fragments that comprise highly-represented CDR domains. | 07-11-2013 |
20130172263 | VH4 CODON SIGNATURE FOR MULTIPLE SCLEROSIS - The present invention provides for the diagnosis and prediction of multiple sclerosis (MS) in subject utilizing a unique a codon signature in VH4 expressing B cells that has now been associated with MS and not with any other autoimmune disease. | 07-04-2013 |
20130164367 | TREATMENT OF NEURODEGENERATIVE DISEASE WITH CREB-BINDING PROTEIN - The present invention relates to improving cognition and treating of neurodegenerative disease using CREB-binding protein. The protein may be delivered to the brain by an expression vector, in particular a lentiviral vector. | 06-27-2013 |
20130150442 | OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCERS - The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided. | 06-13-2013 |
20130150308 | VH4 CODON SIGNATURE FOR MULTIPLE SCLEROSIS - The present invention provides for the diagnosis and prediction of multiple sclerosis (MS) in subject utilizing a unique a codon signature in VH4 expressiong B cells that has now been associated with MS and not with any other autoimmune disease. | 06-13-2013 |
20130143935 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR - The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively. | 06-06-2013 |
20130143885 | CHEMICAL INDUCERS OF NEUROGENESIS - The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy. | 06-06-2013 |
20130143227 | REGULATION OF WNT/BETA-CATENIN SIGNALING - A composition and method for detecting the ability of a compound to modulate the activity of LGR4, LGR5, or LGR6 receptors in a cell. LGR4, LGR5, and LGR6 are capable of activating the Wnt/β-catenin signaling system which plays essential roles in embryonic development and in the self-renewal and maintenance of adult stem cells. | 06-06-2013 |
20130140950 | MEMS-BASED CANTILEVER ENERGY HARVESTER - The claimed invention is directed to integrated energy-harvesting piezoelectric cantilevers. The cantilevers are fabricated using sol-gel processing using a sacrificial poly-Si seeding layer. Improvements in film microstructure and electrical properties are realized by introducing a poly-Si seeding layer and by optimizing the poling process. | 06-06-2013 |
20130131628 | DEVICE AND METHOD FOR SUSTAINED RELEASE OF THERAPEUTIC AGENT - Devices and methods for administering a therapeutic agent, comprising an implantable delivery device. Exemplary embodiments comprise a reservoir in fluid communication with a channeled member, and a solid matter therapeutic agent disposed within the reservoir. | 05-23-2013 |
20130131076 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS - This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome. | 05-23-2013 |
20130116547 | Measurement of Anaplerotic Flux by Hyperpolarization Transfer - Methods and composition for metabolic imaging are provided. For example, in certain aspects, methods for hyperpolarization transfer combined with hyperpolarization are provided. Furthermore, the invention provides methods for detecting magnetic resonance signals for biological processes such as anaplerosis. | 05-09-2013 |
20130096111 | Methods Involving Aldose Reductase Inhibitors - Embodiments of the invention include methods and compositions involving aldose reductase inhibitors for the treatment of inflammation, including uveitis and asthma. | 04-18-2013 |
20130093497 | TUNNEL FIELD EFFECT TRANSISTOR (TFET) WITH LATERAL OXIDATION - A vertical-mode tunnel field-effect transistor (TFET) is provided with an oxide region that may be laterally positioned relative to a source region. The oxide region operates to reduce a tunneling effect in a tunnel region underlying a drain region, during an OFF-state of the TFET. The reduction in tunneling effect results in a reduction or elimination of a flow of OFF-state leakage current between the source region and the drain region. The TFET may have components made from group III-V compound materials. | 04-18-2013 |
20130090571 | METHODS AND SYSTEMS FOR MONITORING AND PREVENTING PRESSURE ULCERS - The present invention relates generally to the prevention and treatment of pressure ulcers and a platform for monitoring, prevention and management of pressure ulcer using a pressure mapping system that records a patient's bed posture, tracks different limbs along with associated statistical pressure image data and produces a summary report for care givers after data analysis and risk assessment. The methodology allows care givers to utilize the stress data and schedule the repositioning of the patient more effectively. The invention relates to creation and using algorithms and analytics for monitoring, prevention and management of pressure ulcers which include time-stamped whole-body pressure distribution data collection and profiling; posture classification, limb detection and tracking; quality of turn and risk assessment; turning schedule and nursing staff utilization for pressure ulcer management; and patient status reporting system customized for caregivers. | 04-11-2013 |
20130089498 | COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELLS BASED ON PEPTIDE BINDING - Methods and compositions are described for classifying cells and/or peptides that associate or bind with a particular characteristic pattern to a plurality of cells or cell lines. Aspects of the invention also include the use of peptide(s) having an appropriate binding characteristic to deliver a drug to a cell or cell population. | 04-11-2013 |
20130086370 | COMBINED BRANCH TARGET AND PREDICATE PREDICTION - Embodiments provide methods, apparatus, systems, and computer readable media associated with predicting predicates and branch targets during execution of programs using combined branch target and predicate predictions. The predictions may be made using one or more prediction control flow graphs which represent predicates in instruction blocks and branches between blocks in a program. The prediction control flow graphs may be structured as trees such that each node in the graphs is associated with a predicate instruction, and each leaf associated with a branch target which jumps to another block. During execution of a block, a prediction generator may take a control point history and generate a prediction. Following the path suggested by the prediction through the tree, both predicate values and branch targets may be predicted. Other embodiments may be described and claimed. | 04-04-2013 |
20130071418 | Physicochemical (PCP) Based Consensus Sequences and Uses Thereof - Provided herein is a computational method for designing a PCP-consensus protein for a family of related proteins. The method uses a consensus alignment of a protein domain common to all the related proteins, which may or may not be substantially biased, from which an average value of p, e.g., 5, physicochemical properties are calculated for each amino acid in the alignment. The PCP-consensus protein has a sequence derived from an alignment of protein domains from a family of related proteins, said sequence containing one or more motifs common to all of the proteins. Also provided are the PCP-consensus proteins, kits comprising the same, datasets of aligned consensus sequences used to derive the PCP-consensus proteins and methods of eliciting an immune response, diagnosing or treating an infectious disease using the same. | 03-21-2013 |
20130064091 | METHOD AND APPARATUS FOR CONGESTION-AWARE ROUTING IN A COMPUTER INTERCONNECTION NETWORK - The present disclosure relates to an example of a method for a first router to adaptively determine status within a network. The network may include the first router, a second router and a third router. The method for the first router may comprise determining status information regarding the second router located in the network, and transmitting the status information to the third router located in the network. The second router and the third router may be indirectly coupled to one another. | 03-14-2013 |
20130059906 | METHODS AND COMPOSITIONS FOR INFLUENCING TUMORS USING MICRORNA-185 AS A TUMOR SUPPRESSOR - The present invention is directed to the use of microRNA-185 (miR-185) as a tumor suppressor. Embodiments of the invention are directed to the use of miR-185 to modulate the expression of tumor-causing genes and to treat subjects. | 03-07-2013 |
20130046151 | SYSTEM AND METHOD FOR REAL-TIME MEASUREMENT OF SLEEP QUALITY - An embodiment of the invention is directed to a method for the real time monitoring and measurement of sleep quality of a subject comprising the steps of; obtaining information from the subject using sensory signals; analyzing the information contained within the signals using signal processing and artificial intelligence; and using the analyzed information to create a protocol to improve the sleep quality of the subject. Another embodiment of the invention is directed to a system for real time monitoring and measurement of sleep quality of a subject comprising: a means for obtaining sensory information from the subject; a means for transmitting the sensory information; a means for analyzing the sensory information; and a means for creating a protocol to improve the sleep quality of the subject. | 02-21-2013 |
20130041247 | OPTOACOUSTIC / PHOTOACOUSTIC / ACOUSTIC IMAGING SYSTEM USING PROBE BEAM DEFLECTION - Embodiments of the invention are directed to a non-contact optical method using a probe beam deflection technique (PBDT) to detecting acoustic waves transiting an acoustic coupling medium. | 02-14-2013 |
20130035284 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES - The present invention concerns methods and compositions involving small molecule inhibitors for the treatment or prophylaxis of flavivirus infection, such as dengue virus and West Nile virus. | 02-07-2013 |
20130028914 | Antibodies that Bind Tau Oligomers - Embodiments of the invention are directed to compositions and methods related to Tau oligomers and Tau oligomer specific antibodies. | 01-31-2013 |
20130024208 | Advanced Multimedia Structured Reporting - Embodiments of methods, systems, and apparatuses for generating a composited multimedia-based report are described. In one embodiment, a method includes capturing a medical image configured to be displayed on a medical image display device. The present methods may be independent of the medical image display, and may be able to capture images from any proprietary medical image viewer. The method may also include capturing description data related to the medical image. Additionally, the method may include processing the medical image and the description data related to the medical image on a data processing device. Also, the method may include storing the medical image and the description data related to the medical image in a data storage device. | 01-24-2013 |
20130023529 | Methods Involving Aldose Reductase Inhibitors - Embodiments of the invention include methods and compositions involving aldose reductase inhibitors for the treatment of inflammation, including uveitis and asthma. | 01-24-2013 |
20130023031 | Pseudoinfectious Flavivirus and Uses Thereof - The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the | 01-24-2013 |
20130022223 | AUTOMATED METHOD OF CLASSIFYING AND SUPPRESSING NOISE IN HEARING DEVICES - The claimed invention is directed to a real-time noise classification and tuning system for cochlear implant and other hearing device applications. The system is capable of automatically selecting the optimized parameters of a noise suppression algorithm in response to different noisy environments. The feature vector and the classifier deployed in the system to automatically identify the background noise environment are selected so that the computation burden is kept low to achieve a real-time throughput. The results reported herein indicate improvement in speech enhancement when using this intelligent real-time hearing device system. | 01-24-2013 |
20130018088 | METHODS AND COMPOSITIONS FOR ANTI-EGFR TREATMENT - In some embodiments, the present invention provides methods for enhancing the sensitivity of cancer cells to anti-EGFR treatment, wherein the method comprises the introduction of a miR-200 miRNA to the cancer cells. In other embodiments, the present invention provides methods for treating cancer by exposing the cancer cells to an anti-EGFR composition after the above-mentioned enhancement step. In other embodiments, the present invention provides methods for assessing and enhancing the sensitivity of cancer cells to anti-EGFR treatment. In various other embodiments, the present invention provides compositions and expression vectors for practicing the afore-mentioned methods. | 01-17-2013 |
20130005690 | S-NITROSYLATION OF GLUCOSYLATING TOXINS AND USES THEREFOR - Provided herein are methods for ameliorating the pathophysiology cysteine protease exotoxin comprising the step of administering to said individual an effective dose of an S-nitrosylating agent and an inositol phosphate or analog thereof. | 01-03-2013 |
20130004473 | Methods and Biomarkers for the Detection of Dengue Hemorrhagic Fever - The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF. | 01-03-2013 |
20130001814 | SUPERFINE FIBER CREATING SPINNERET AND USES THEREOF - Apparatuses and methods for the production of superfine fibers. | 01-03-2013 |
20130000653 | Arm Movement Restraining and Permission Cord for Patients Receiving Cardiac Pacemakers and Similar Implants - An arm movement restraining and permission cord apparatus is disclosed for patients receiving cardiac pacemakers and similar implants to prevent patients for arm movements that may result in health risk due to leads being pulled out from the heart muscle. | 01-03-2013 |
20120321637 | COMBINATION CANCER THERAPY WITH HERV INHIBITION - Embodiments are directed to compositions and methods related combination therapy with HERV inhibition. | 12-20-2012 |
20120289796 | Noninvasive, Accurate Glucose Monitoring with OCT By Using Tissue Warming and Temperature Control - A new OCT system and method are disclosed, where the system includes a probe equipped with a heating element and a high heat conductive member to warm a tissue site to be scanned to an elevated and/or to maintain the elevated tissue temperature with a temperature variation of less than or equal to 1° C. to improve an accuracy and reliability of an OCT glucose concentration value other long measurement durations. The new OCT system and method can also be equipped with pressure components to reduce a pressure exerted on the tissue site to a minimal constant pressure. | 11-15-2012 |
20120282578 | SYSTEM FOR STRATEGIC MEMORY AND REASONING (SMART) - A cognitive strategy instruction program focusing specifically on the ability to reason, abstract, and generalize information for more efficient learning is described herein. The combination of the strategies in tandem with the intensive presentation and process-related (rather than content-related) approach are unique to the SMART program of the present invention. The SMART approach encompasses various cognitive processes in succession, such as working memory, attention, and synthesis of pre-existing knowledge with new information in contrast to most current cognitive interventions focus on specific aspects of cognition such as working memory in isolation. The SMART program of the present invention can be extended with slight modifications if necessary to adults, particularly in senior citizens to enhance one or more cognitive processes. | 11-08-2012 |
20120276520 | ASSAY FOR MUTATIONS IN STEM CELLS AND THEIR DERIVATIVES - The present invention provides methods to assess the genetic safety of stem cells, whether endogenous embryonic stem cells, somatic or adult stem cells, or artificially induced stem cells from non-pluripotent cells, and their differentiated derivatives for use in human medicine, and the applications of modified stem cells to testing environmental or potential genetic or epigenetic modulators such as culture media formulations, substrates or scaffolds, additives, reagents, processes, and processing materials used to prepare stem cells for use. | 11-01-2012 |
20120258936 | INOSITOL HEXAKISPHOSPHATE ANALOGS AND USES THEREOF - Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat a | 10-11-2012 |
20120251565 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING BURKHOLDERIA INFECTION - The present invention provides a protein or a fragment or a variant of said protein, wherein the protein, fragment, or variant is capable of producing a protective immune response in an animal, wherein the immune response is protective against infection by | 10-04-2012 |
20120245128 | RAPID DETECTION AND QUANTIFICATION OF MODIFICATION OF MEDICINAL COMPOUNDS AND DRUG RESISTANCE ACTIVITY - The present disclosure in general relates to methods, systems, and apparatus for identifying modification of a medicinal compound exposed to a sample for use in determining which treatment to provide to a subject in need thereof. | 09-27-2012 |
20120238609 | Methods for Treating COPD - Embodiments of the invention include methods and compositions involving aldose reductase inhibitors for treating COPD. | 09-20-2012 |
20120220482 | COMPOSITIONS AND METHODS FOR SCREENING PEPTOID LIBRARIES - Certain embodiments are directed to methods for screening synthetic libraries and characterizing the resultant hits that combines many of the attractive features of bead library screening and microarray-based analysis in a seamless fashion. | 08-30-2012 |
20120219972 | DIAGNOSIS AND TREATMENT OF EHRLICHIOSIS - The present invention provides an isolated | 08-30-2012 |
20120207711 | INFECTIVITY-ENHANCED CONDITIONALLY-REPLICATIVE ADENOVIRUS AND USES THEREOF - A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to specific promoter control or mutations in E1a or E1b genes. | 08-16-2012 |
20120207186 | TERAHERTZ QUANTUM CASCADE LASERS (QCLS) - Quantum cascade lasers (QCLs), and methods of manufacture of QCLs, comprising an active portion. In some embodiments, the active portion can comprise: a plurality of tensiley strained quantum barrier layers, each comprising Ga | 08-16-2012 |
20120190975 | NANOPARTICLES FOR USE IN TUMOR DIAGNOSIS AND THERAPY - The present invention relates to diagnostic and therapeutic nanoparticles. More particularly, the present invention relates to creating a copper (Cu)-based nanoparticle and a method for making the same. The Cu-based nanoparticles can further be incorporated with additional therapeutic or diagnostic compounds and used for the diagnosis and treatment of tumors. | 07-26-2012 |
20120189877 | COMPOSITE CARBON FIBER ELECTRODES INCORPORATING POROUS HIGH SURFACE AREA CARBON - The claimed invention uses activated carbon fibers that incorporate porous carbon with a suitable pore size to maximize capacitance. The porous carbon material is prepared using a template, followed by incorporation into a matrix polymer and electrospinning of the mixture. Subsequent thermal treatments retain the fiber form, and a composite carbon fiber incorporating templated porous carbon is attained. The resulting electrode is binder free and 100% electrochemically active. Energy densities up to 41 Wh/kg in energy density 1.5 kW/kg in power density (electrode weight only) have been achieved. | 07-26-2012 |
20120180802 | SHAPE MEMORY DEVICES AND THEIR USE IN CONTROLLING DEVICE-ENVIRONMENT INTERACTIONS - The invention is directed to shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof. The invention is further directed to methods of controlling the nature of the interaction of a shape memory device with the environment in which it is operating. | 07-19-2012 |
20120179055 | METHOD AND DEVICE FOR EARLY DETECTION OF HEART ATTACK - A device and method for heart performance characterization and abnormality detection is disclosed herein. The device and method analyze and characterize cardiac electrophysiological signals which help in the diagnosis of myocardial ischemia in advance of a heart attack. | 07-12-2012 |
20120171222 | METHODS AND COMPOSITIONS INVOLVING NUCLEOTIDE REPEAT DISORDERS - The present invention concerns the methods and compositions involving nucleic acids with long repeat sequences. In some embodiments of the invention, there are methods for generating such a nucleic acid, and in other methods, there are methods for using such a nucleic acid to screen for candidate therapeutic compounds. Furthermore the present invention relates to methods of screening for Notch inhibitors and other substances that may be used to treat muscle loss and wasting. | 07-05-2012 |
20120168630 | LIQUID SCINTILLATOR FOR 3D DOSIMETRY FOR RADIOTHERAPY MODALITIES - A liquid scintillator detector for three-dimensional dosimetric measurement of a radiation beam is provided wherein a volumetric phantom liquid scintillator is exposed to the radiation beam to produce light that is captured by the cameras that provide a three-dimensional image of the beam. | 07-05-2012 |
20120164139 | Dopamine 3 receptor agonist and antagonist treatment of gastrointestinal motility disorders - Provided herein are methods of treating gastrointestinal motility disorders by targeting the dopamine 3 receptor (D3R). A D3R agonist is administered to a subject to decrease gastrointestinal motility to treat the disorder. A D3R antagonist is administered to a subject to decrease gastrointestinal motility to treat the disorder. | 06-28-2012 |
20120148591 | Antibodies That Bind Amyloid Oligomers - Embodiments of the invention are directed to compositions and methods related to immunogenic compositions comprising the amino acid sequence of SEQ ID NO:1 and amyloid oligomer specific antibodies that specifically bind an oligomer comprising such a peptide. | 06-14-2012 |
20120142102 | ISOLATION OF HUMAN UMBILICAL CORD BLOOD-DERIVED MESENCHYMAL STEM CELLS - Human umbilical cord blood (UCB) contains mesenchymal stem cells (MSCs) that have higher multipotentiality than adult marrow-derived MSCs. However, it has been difficult to obtain these cells because the frequency of MSCs in UCB is extremely rare (0.4-30 out of 1×10 | 06-07-2012 |
20120135408 | UNC-45A SPLICE VARIANTS BASED CANCER DIAGNOSTICS AND THERAPEUTICS - Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed. | 05-31-2012 |
20120115746 | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING IRRITABLE BOWEL SYNDROME - Compositions and methods for diagnosing and treating CVH and CVH-associated disorders are disclosed. Genes differentially expressed in CVH tissues relative to normal tissues are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used as markers of CVH. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products. | 05-10-2012 |
20120114636 | LOW MOLECULAR WEIGHT CYCLIN E (LMW-E) AS A BIOMARKER FOR PERSONALIZATION OF CANCER THERAPIES - Methods are disclosed for predicting a patient response to anti-Her2 therapy or anti-aromatase therapy. In certain embodiments, the methods involve the identification of low molecular weight cyclin E (LMW-E) in cancers, such as breast cancer cells, as a predictive and prognostic marker. In further embodiments, LMW-E expression by a cancerous or pre-cancerous cell may be used to predict response to an aromatase inhibitor and/or CDK2 inhibitor, and determination of LMW-E expression may be used in the personalization of cancer therapies. | 05-10-2012 |
20120114079 | RADIO ARCHITECTURE FOR AN ULTRA LOW POWER RECEIVER - An ultra low power radio receiver architecture based on phase locked loop is provided. Embodiments of an ultra low power radio receiver architecture based on phase locked loop can detect a complex modulated MSK signal with only a single path receiver chain. According to an embodiment of the present invention, the overall power consumption of the radio receiver in the present invention can be reduced by almost fifty percent compared to that of the conventional complex path radio receiver architecture. The radio receiver architecture of the invention is suitable for the ultra low power radio application such as wireless sensor networks (WSN). | 05-10-2012 |
20120100181 | Attenuation of Encephalitogenic Alphavirus and Uses Thereof - The present invention is drawn to generating attenuated and less cytopathic forms of New World alphaviruses that can be used in immunogenic compositions as vaccines against both Old and New World alphaviruses. In this regard, the present invention discloses that the N-terminal, ˜35-aa-long peptide of VEEV, EEEV and, most likely, of WEEV capsid proteins plays the most critical role in the downregulation of cellular transcription and development of cytopathic effect. The identified, VEEV-specific peptide, C | 04-26-2012 |
20120095443 | NANOCHANNELED DEVICE AND RELATED METHODS - A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate. | 04-19-2012 |
20120089794 | METHODS AND DEVICES FOR DETERMINING QUALITY OF SERVICES OF STORAGE SYSTEMS - Methods and systems for allowing access to computer storage systems. Multiple requests from multiple applications can be received and processed efficiently to allow traffic from multiple customers to access the storage system concurrently. | 04-12-2012 |
20120070846 | METHODS FOR DETECTING MOLECULE-MOLECULE INTERACTIONS WITH A SINGLE DETECTION CHANNEL - A single molecule or molecule complex detection method is disclosed in certain aspects, comprising nano- or micro-fluidic channels. | 03-22-2012 |
20120065521 | NEEDLE BIOBSY IMAGING METHOD - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample. | 03-15-2012 |
20120065495 | NEEDLE BIOBSY IMAGING SYSTEM - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample. | 03-15-2012 |
20120064372 | METHOD FOR IMPARTING ANTIMICROBIAL ACTIVITY TO A MEDICAL DEVICE - A method for imparting broad spectrum antimicrobial activity to a medical device. The medical device is sequentially contacted with a first antimicrobial component, such as an antiseptic, and thereafter with a second antimicrobial component, such as a mixture of antibiotics. The first component may be a guanidium compound, such as chlorhexidine. The second component may be a mixture of a tetracycline, such as minocycline, and a rifamycin, such as rifampin. | 03-15-2012 |
20120064143 | INHIBITION OF MAMMALIAN TARGET OF RAPAMYCIN - Disclosed are microcapsules that include an inhibitor of the mammalian target of rapamycin (mTOR) within the microcapsules, and pharmaceutical compositions and kits that include the microcapsules. Also disclosed are methods for treating or preventing an age-related disease, condition, or disorder in a subject that involve administering to a subject a pharmaceutically effective amount of microcapsules that includes an inhibitor of mTOR within the microcapsules. | 03-15-2012 |
20120043501 | Polyamine/Alkali Salt Blends for Carbon Dioxide Removal From Gas Streams - Novel solvents and methods of use for the removal of CO | 02-23-2012 |
20120014424 | COMMUNICATING CHANNEL STATE INFORMATION USING PREDICTIVE VECTOR QUANTIZATION - Techniques are generally described here for communicating channel state information using predictive vector quantization. In some examples, a method may include measuring channel state information based, at least in part, on signals received over a communications channel. An error vector may be calculated between the measured channel state information and predicted channel state information. The error vector may be quantized, and subsequent channel state information may be predicted based, at least in part, on the quantized error vector. | 01-19-2012 |
20120005028 | AD AUCTION OPTIMIZATION - The present disclosure generally relates to ad auction optimization. In some examples, methods, systems, and computer programs for ad auction optimization using machine learning algorithms to estimate a likelihood that a consumer will purchase an advertised product and balance long term and short term goals to determine modeled data for a keyword in an auction are described. | 01-05-2012 |
20110319759 | OPTICALLY GUIDED NEEDLE BIOPSY SYSTEM USING MULTI-MODAL SPECTROSCOPY - The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement. | 12-29-2011 |
20110319338 | PEPTIDES THAT BIND EUKARYOTIC TRANSLATION INITIATION FACTOR 4E - Methods, compositions and kits for treating proliferative and non-proliferative diseases associated with abnormal protein synthesis. Chimeric peptide constructs are comprised in compositions and kits for use in the treatment of proliferative diseases, such as ovarian cancer, and for inhibiting protein synthesis in a tumor cell compared to a non-tumor cell. | 12-29-2011 |
20110318313 | Modulation of Splenocytes in Cell Therapy for Traumatic Brain Injury - The invention provides methods for treating traumatic brain injury. The invention is generally directed to treating traumatic brain injury by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4 | 12-29-2011 |
20110313538 | BI-LAYERED BONE-LIKE SCAFFOLDS - Disclosed are biomedical scaffolds that may be used, for example, for treatment of bone diseases and bone repair. Methods of preparing such scaffolds are also disclosed. These scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Also disclosed are kits that include the scaffolds set forth herein. | 12-22-2011 |
20110313415 | Medical Devices, Apparatuses, Systems, and Methods - Apparatuses and systems for enabling electrical communication with a device positionable within a body cavity of a patient. Apparatuses and systems for magnetically positioning a device within a body cavity of a patient. Medical devices. Methods of use. | 12-22-2011 |
20110311558 | Recombinant Bone Marrow Stromal Antigen-2 in the Treatment of Autoimmune Diseases - Methods, compositions and kits are disclosed for inhibiting interferon production and modulating immune responses, particularly an autoimmune response. In certain embodiments, the methods involve administering an effective amount of a BST2 protein or a nucleic acid encoding an BST2 protein to treat an autoimmune disease or disorder. | 12-22-2011 |
20110306948 | METHODS AND COMPOSITIONS RELATED TO TH-1 DENDRITIC CELLS - Certain embodiments of the invention are directed to methods for inducing an immunologic response to a tumor in a patient using mature dendritic cells transfected with a nucleic acid composition encoding one or more tumor antigens and loaded with a corresponding tumor antigen composition. | 12-15-2011 |