GENETIC MARKERS OF SCHIZOPHRENIA ENDOPHENOTYPES

Abstract

This document provides methods and materials related to genetic markers of schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD), (collectively referred to herein as "schizophrenia spectrum disorders" or SSDs). For example, methods for using such genetic markers to identify an SSD (e.g., SZ) endophenotype are provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of U.S. patent application Ser. No. 12/612,584, filed on Nov. 4, 2009, which is a continuation of International Patent Application No. PCT/US2009/058483, filed Sep. 25, 2009, which claims priority to U.S. Provisional Application Ser. No. 61/100,176, filed on Sep. 25, 2008, each of which are hereby incorporated by reference in their entirety.

TECHNICAL FIELD

[0003] This document provides methods and materials related to genetic markers of endophenotypes of schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD), (collectively referred to herein as "schizophrenia spectrum disorders" or SSDs). For example, this document provides methods for using such genetic markers to identify an SSD (e.g., SZ) endophenotype in a subject.

BACKGROUND

[0004] The schizophrenia spectrum disorders include schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). Schizophrenia (SZ) is considered a clinical syndrome, and is probably a constellation of several pathologies. Substantial heterogeneity is seen between cases, which is thought to reflect multiple overlapping etiologic factors, including both genetic and environmental contributions. SD is characterized by the presence of affective (depressive or manic) symptoms and schizophrenic symptoms within the same, uninterrupted episode of illness. SPD is characterized by a pervasive pattern of social and interpersonal deficits marked by acute discomfort with, and reduced capacity for, close relationships as well as by cognitive or perceptual distortions and eccentricities of behavior, beginning by early adulthood and present in a variety of contexts.

[0005] Endophenotypes are quantitative, continuously distributed traits, symptoms or disease dimensions s typically assessed by laboratory-based methods or clinical observation. The use of endophenotypes allows complex psychiatric illnesses like SZ to be divided into more stable, readily definable categories that are more amendable to identification of clear genetic associations, as they are generally more reflective of specific underlying biological processes. Identifying the genetic basis of specific endophenotypes also facilitates identification and development of new drugs that target the specific physiological deficits underlying disease. See Braff et al., Schiz. Bull. 33(1):21-32 (2007).

SUMMARY

[0006] This disclosure provides methods of determining severity of SZ endophenotypes in subjects diagnosed with SZ based on genetic variants in genes involved in a number of pathways including: glutamate signaling and metabolism, cell adhesion, cytoskeletal architecture, vesicle formation, and trafficking, G-protein coupled receptors, carrier proteins and transporters, cell cycle modulators, neuronal development, calcium/calmodulin signaling, neuropeptide signaling, and several additional genes identified by virtue of their interaction with genes in high impact pathways and their expression in the central nervous system. This disclosure provides methods and claims relating to determining the severity of an SSD endophenotype according to a subject's underlying genetic architecture. As described herein, methods for determining severity of an SSD endophenotype include evaluation of SNPs for genes relating to endophenotypes in SSDs including SZ, SPD, and SD.

[0007] In one aspect, this document features methods for determining a severity of a schizophrenia (SZ) endophenotype in a human subject. Methods can include determining the identity of an allele of at least one single nucleotide polymorphism (SNP) listed in Tables 1-3 in the subject; comparing the identity of the allele in the subject with a reference allele, wherein the reference allele is associated with a severity of a specific endophenotype; and determining the severity of the endophenotype in the subject, based on the comparison of the allele in the subject to the reference allele; thereby determining the severity of the schizophrenia endophenotype in the subject.

[0008] In another aspect, this document features methods for selecting a treatment for schizophrenia in a human subject. Methods can include determining the identity of an allele of at least one polymorphism listed in Tables 1-3 in the subject; comparing the identity of the allele in the subject with a reference allele, wherein the reference allele is associated with a severity of a specific endophenotype; determining the severity of the endophenotype in the subject, based on the comparison of the allele in the subject to the reference allele; and selecting a treatment for the subject based on the determined severity of the specific schizophrenia endophenotype for the subject.

[0009] A SZ endophenotype can be a quantitative trait that can be measured using one or more of PANSS Total composite score, PANSS Positive composite score, PANSS Negative composite score, and PANSS General Psychopathology composite score. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Total composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:417, 1471, 704, 419, 1602, 1401, and 1076. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Positive composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:1364, 1562, 534, and 1754. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Total composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:1504, 1401, 275, 165, and 129. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Total composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:688, 1882, 1751, and 1285.

[0010] A schizophrenia endophenotype can include one or more of: a Positive Symptom selected from the group consisting of P1--delusions, P2--conceptual disorganization, P3--hallucinatory behavior, P4--exitement, P5--grandiosity, P6--suspiciousness, P7--hostility; a Negative Symptom selected from the group consisting of N1--blunted affect, N2--emotional withdrawal, N3--poor rapport, N4--passive/appathetic social withdrawal, N5--difficulty in abstract thinking, N6--lack of spontaneity and flow of conversation, N7--stereotyped thinking; or a general psychopathology symptom selected from the group consisting of G1--somatic concern, G2--anxiety, G3--guilt feelings, G4--tension, G5--mannerisms and posturing, G6--depression, G7--motor retardation, G8--uncooperativeness, G9--unusual thought content, G10--disorentation, G11--poor attention, G12--lack of judgment and insight, G13--disturbance of volition, G14--poor impulse control, G15--preoccupation, and G16--active social avoidance.

[0011] Determining the identity of an allele can include obtaining a sample comprising DNA from the subject, and determining identity of the nucleotide at the polymorphic site. Determining the identity of the nucleotide can include contacting the sample with a probe specific for a selected allele of the polymorphism, and detecting the formation of complexes between the probe and the selected allele of the polymorphism, wherein the formation of complexes between the probe and the test marker indicates the presence of the selected allele in the sample. Determining the identity of an allele can include determining the identity of the nucleotide at position 31 of one of SEQ ID NOs: 1-1894. A reference allele can represent an allele in a subject or subjects who have a known severity of the endophenotype.

[0012] A subject can be a patient, i.e., a human patient, having or suspected of having SZ. A subject can have one or more risk factors associated with SZ. Risk factors associated with SZ can include one or more of: a relative afflicted with a schizophrenia spectrum disorder (SSD); and a genetically based phenotypic trait associated with risk for a SSD. Methods can further include selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele. Methods can further include stratifying a subject population for analysis of a clinical trial based on the identity of the allele in the subjects. Methods can further include confirming a severity of a SZ endophenotype using psychometric instruments. Methods can further include administering the selected treatment to the subject. A selected treatment can be an anti-psychotic drug, an anti-depressant drug, anti-anxiety drug, mood stabilizer, selective serotonin reuptake inhibitor (SSRI), psychotherapy, or a stimulant. A treatment can be a combination of an anti-psychotic drug, plus one or more of an anti-depressant drug, anti-anxiety drug, mood stabilizer, selective serotonin reuptake inhibitor (SSRI), psychotherapy, or a stimulant. A treatment can be psychotherapy. Methods can further include recording the identity of the allele in a tangible medium. A tangible medium can include a computer-readable disk, a solid state memory device, or an optical storage device.

[0013] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although methods and materials similar or equivalent to those described herein can be used to practice the invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.

[0014] The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims.

DETAILED DESCRIPTION

[0015] This document provides methods for determining severity of an endophenotype in a patient diagnosed with SZ based on evaluation of single nucleotide polymorphisms (SNPs) for genes relating to endophenotypes of SSDs including schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). As described herein, bioinformatic and genetic analyses provided evidence of association of the disclosed SNP alleles with severity of intermediate phenotypes, or "endophenotypes," in patients diagnosed with SZ.

DEFINITIONS

[0016] As used herein, an "endophenotype" is a quantitative psychiatric trait exhibited by patients diagnosed with SZ. One way that such traits can be measured is by clinical assessment made by administering the Positive and Negative Syndrome Scale (PANSS) (Kay et al., Schizophr. Bull. 13:261-276 (1987); Kay et al., Br. J. Psychiatry Suppl 59-67 (1989); Leucht et al., Schizophr. Res. 79:231-238 (2005)).

[0017] As used herein, an "allele" is one of a pair or series of genetic variants of a polymorphism at a specific genomic location. An "endophenotypic allele" is an allele that is statistically associated with severity of a specific endophenotype.

[0018] A "haplotype" is one or a set of signature genetic changes (polymorphisms) that are normally grouped closely together on the DNA strand, and are usually inherited as a group; the polymorphisms are also referred to herein as "markers." A "haplotype" as used herein is information regarding the presence or absence of one or more genetic markers in a given chromosomal region in a subject. A haplotype can consist of a variety of genetic markers, including indels (insertions or deletions of the DNA at particular locations on the chromosome); single nucleotide polymorphisms (SNPs) in which a particular nucleotide is changed; microsatellites; and minisatellites.

[0019] Microsatellites (sometimes referred to as a variable number of tandem repeats or VNTRs) are short segments of DNA that have a repeated sequence, usually about 2 to 5 nucleotides long (e.g., CACACA), that tend to occur in non-coding DNA. Changes in the microsatellites sometimes occur during the genetic recombination of sexual reproduction, increasing or decreasing the number of repeats found at an allele, changing the length of the allele. Microsatellite markers are stable, polymorphic, easily analyzed and occur regularly throughout the genome, making them especially suitable for genetic analysis.

[0020] "Copy number variation" (CNV), as used herein, refers to variation from the normal diploid condition for a gene or polymorphism. Individual segments of human chromosomes can be deleted or duplicated such that the subject's two chromosome carry fewer than two copies of the gene or polymorphism (a deletion or deficiency) or two or more copies (a duplication).

[0021] "Linkage disequilibrium" refers to when the observed frequencies of haplotypes in a population does not agree with haplotype frequencies predicted by multiplying together the frequency of individual genetic markers in each haplotype.

[0022] The term "chromosome" as used herein refers to a gene carrier of a cell that is derived from chromatin and comprises DNA and protein components (e.g., histones). The conventional internationally recognized individual human genome chromosome numbering identification system is employed herein. The size of an individual chromosome can vary from one type to another with a given multi-chromosomal genome and from one genome to another. In the case of the human genome, the entire DNA mass of a given chromosome is usually greater than about 100,000,000 base pairs. For example, the size of the entire human genome is about 3×10⁹ base pairs.

[0023] The term "gene" refers to a DNA sequence in a chromosome that codes for a product (either RNA or its translation product, a polypeptide). A gene contains a coding region and includes regions preceding and following the coding region (termed respectively "leader" and "trailer"). The coding region is comprised of a plurality of coding segments ("exons") and intervening sequences ("introns") between individual coding segments.

[0024] The term "probe" refers to an oligonucleotide. A probe can be single stranded at the time of hybridization to a target. As used herein, probes include primers, i.e., oligonucleotides that can be used to prime a reaction, e.g., a PCR reaction.

[0025] The term "label" or "label containing moiety" refers in a moiety capable of detection, such as a radioactive isotope or group containing same, and nonisotopic labels, such as enzymes, biotin, avidin, streptavidin, digoxygenin, luminescent agents, dyes, haptens, and the like. Luminescent agents, depending upon the source of exciting energy, can be classified as radioluminescent, chemiluminescent, bioluminescent, and photoluminescent (including fluorescent and phosphorescent). A probe described herein can be bound, e.g., chemically bound to label-containing moieties or can be suitable to be so bound. The probe can be directly or indirectly labeled.

[0026] The term "direct label probe" (or "directly labeled probe") refers to a nucleic acid probe whose label after hybrid formation with a target is detectable without further reactive processing of hybrid. The term "indirect label probe" (or "indirectly labeled probe") refers to a nucleic acid probe whose label after hybrid formation with a target is further reacted in subsequent processing with one or more reagents to associate therewith one or more moieties that finally result in a detectable entity.

[0027] The terms "target," "DNA target," or "DNA target region" refers to a nucleotide sequence that occurs at a specific chromosomal location. Each such sequence or portion is preferably at least partially, single stranded (e.g., denatured) at the time of hybridization. When the target nucleotide sequences are located only in a single region or fraction of a given chromosome, the term "target region" is sometimes used. Targets for hybridization can be derived from specimens which include, but are not limited to, chromosomes or regions of chromosomes in normal, diseased or malignant human cells, either interphase or at any state of meiosis or mitosis, and either extracted or derived from living or postmortem tissues, organs or fluids; germinal cells including sperm and egg cells, or cells from zygotes, fetuses, or embryos, or chorionic or amniotic cells, or cells from any other germinating body; cells grown in vitro, from either long-term or short-term culture, and either normal, immortalized or transformed; inter- or intraspecific hybrids of different types of cells or differentiation states of these cells; individual chromosomes or portions of chromosomes, or translocated, deleted or other damaged chromosomes, isolated by any of a number of means known to those with skill in the art, including libraries of such chromosomes cloned and propagated in prokaryotic or other cloning vectors, or amplified in vitro by means well known to those with skill; or any forensic material, including but not limited to blood, or other samples.

[0028] The term "hybrid" refers to the product of a hybridization procedure between a probe and a target.

[0029] The term "hybridizing conditions" has general reference to the combinations of conditions that are employable in a given hybridization procedure to produce hybrids, such conditions typically involving controlled temperature, liquid phase, and contact between a probe (or probe composition) and a target. Conveniently and preferably, at least one denaturation step precedes a step wherein a probe or probe composition is contacted with a target. Guidance for performing hybridization reactions can be found in Ausubel et al., Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (2003), 6.3.1-6.3.6. Aqueous and nonaqueous methods are described in that reference and either can be used. Hybridization conditions referred to herein are a 50% formamide, 2×SSC wash for 10 minutes at 45° C. followed by a 2×SSC wash for 10 minutes at 37° C.

[0030] Calculations of "identity" between two sequences can be performed as follows. The sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second nucleic acid sequence for optimal alignment and non-identical sequences can be disregarded for comparison purposes). The length of a sequence aligned for comparison purposes is at least 30% (e.g., at least 40%, 50%, 60%, 70%, 80%, 90% or 100%) of the length of the reference sequence. The nucleotides at corresponding nucleotide positions are then compared. When a position in the first sequence is occupied by the same nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.

[0031] The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. In some embodiments, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package, using a Blossum 62 scoring matrix with a gap penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.

[0032] As used herein, the term "substantially identical" is used to refer to a first nucleotide sequence that contains a sufficient number of identical nucleotides to a second nucleotide sequence such that the first and second nucleotide sequences have similar activities. Nucleotide sequences that are substantially identical are at least 80% (e.g., 85%, 90%, 95%, 97% or more) identical.

[0033] The term "nonspecific binding DNA" refers to DNA which is complementary to DNA segments of a probe, which DNA occurs in at least one other position in a genome, outside of a selected chromosomal target region within that genome. An example of nonspecific binding DNA comprises a class of DNA repeated segments whose members commonly occur in more than one chromosome or chromosome region. Such common repetitive segments tend to hybridize to a greater extent than other DNA segments that are present in probe composition.

Methods of Determining the Degree of Specific Endophenotypes

[0034] Quantitative traits, by definition, are measured by degree rather than simply presence or absence, like blood glucose or cholesterol. The genetically-based methods described herein can give a biological indication of the degree (or severity) of a phenotype a patient might show, and not be dependent upon the results of a particular psychiatric test done on one particular day. This is similar to testing for LDL receptor variants to understand why a person might have high cholesterol and how it would be best to treat the patient, rather than simply looking at cholesterol levels. In the SZ context, this is particularly important since a subject's presentation of disease may vary from day to day. For example, a subject with SZ may display more mania one day than the next; if a medical professional evaluates them on a day when they are displaying fewer symptoms of mania, an inappropriate treatment plan might be prepared.

[0035] Described herein are a variety of methods for identifying, predicting, or determining severity or degree of a subject's SSD (e.g., SZ) endophenotype. "Severity" includes the whole spectrum of expression of the endophenotype, including both positive and negative scores on the PANSS test, e.g., extremely severe expression to mild or substantially no expression of the endophenotype. As used herein, determining severity or degree of an SSD endophenotype is based on the presence or absence of one or more alleles associated with severity of the endophenotypes in patients diagnosed with SZ as described herein. Ascertaining whether the subject has such an allele is included in the concept of determining SSD (e.g., SZ) endophenotypes as used herein. The presence an allele associated with a particular severity indicates a specific genetic (biological) contribution to the particular endophenotype. Such contributions can be positive (tending to increase the degree of the endophenotype) or negative (tending to decrease the degree of the endophenotype) depending on the specific allele of the polymorphism.

[0036] As used herein, "determining the identity of an allele" includes obtaining information regarding the identity, presence or absence of one or more specific alleles in a subject. Determining the identity of an allele can, but need not, include obtaining a sample comprising DNA from a subject, and/or assessing the identity, presence or absence of one or more genetic markers in the sample. The individual or organization who determines the identity of the allele need not actually carry out the physical analysis of a sample from a subject; the methods can include using information obtained by analysis of the sample by a third party. Thus the methods can include steps that occur at more than one site. For example, a sample can be obtained from a subject at a first site, such as at a health care provider, or at the subject's home in the case of a self-testing kit. The sample can be analyzed at the same or a second site, e.g., at a laboratory or other testing facility.

[0037] Determining the identity of an allele can also include or consist of reviewing a subject's medical history, where the medical history includes information regarding the identity, presence or absence of one or more response alleles in the subject, e.g., results of a genetic test.

[0038] In some embodiments, to determine the identity of an allele described herein, a biological sample that includes nucleated cells (such as blood, a cheek swab or mouthwash) is prepared and analyzed for the presence or absence of preselected markers. Such diagnoses may be performed by diagnostic laboratories, or, alternatively, diagnostic kits can be manufactured and sold to health care providers or to private individuals for self-diagnosis. Diagnostic or prognostic tests can be performed as described herein or using well known techniques, such as described in U.S. Pat. No. 5,800,998.

[0039] Results of these tests, and optionally interpretive information, can be returned to the subject, the health care provider or to a third party payor. The results can be used in a number of ways. The information can be, e.g., communicated to the tested subject, e.g., with a prognosis and optionally interpretive materials that help the subject understand the test results and prognosis. The information can be used, e.g., by a health care provider, to determine whether to administer a specific drug, or whether a subject should be assigned to a specific category, e.g., a category associated with a specific disease endophenotype, or with drug response or non-response. The information can be used, e.g., by a third party payor such as a healthcare payer (e.g., insurance company or HMO) or other agency, to determine whether or not to reimburse a health care provider for services to the subject, or whether to approve the provision of services to the subject. For example, the healthcare payer may decide to reimburse a health care provider for treatments for an SSD if the subject has a particular response allele. As another example, a drug or treatment may be indicated for individuals with a certain allele, and the insurance company would only reimburse the health care provider (or the insured individual) for prescription or purchase of the drug if the insured individual has that response allele. The presence or absence of the response allele in a patient may be ascertained by using any of the methods described herein.

[0040] Alleles Associated with Severity of SSD Endophenotypes

[0041] This document provides methods for determining the degree of an SSD (e.g., SZ) endophenotype based on evaluation of single nucleotide polymorphisms (SNPs) for genes relating to endophenotypes of SZ-spectrum disorders including schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). The alleles described herein can be used both to determine patients who are likely to display higher or lower values for specific endophenotypes and to determine the contribution of genetic makeup and specific biological/cellular pathways to specific endophenotypes and severity thereof. Tables 1-3 and Table A list specific SNPs, variation of which is associated with variations in severity of specific endophenotypes. One of skill in the art will appreciate that other variants can be identified via TDT using families with multiple affected individuals or by Case/Control comparisons using the SNP markers presented herein. Using SNP markers that are identical to or in linkage disequilibrium with the exemplary SNPs, one can determine other alleles, including haplotypes and single SNP alleles in these genes relating response to an endophenotype of an SSD (e.g., of SZ). The allelic variants thus identified can be used equivalently to the exemplary SNPs, e.g., to determine a diagnosis of a specific endophenotype in a patient.

[0042] Markers in Linkage Disequilibrium (LD)

[0043] Linkage disequilibrium (LD) is a measure of the degree of association between alleles in a population. One of skill in the art will appreciate that alleles involving markers in LD with the polymorphisms described herein can also be used in a similar manner to those described herein. Methods of calculating LD are known in the art (see, e.g., Morton et al., Proc. Natl. Acad. Sci. USA 98(9):5217-21 (2001); Tapper et al., Proc. Natl. Acad. Sci. USA 102(33):11835-11839 (2005); Maniatis et al., Proc. Natl. Acad. Sci. USA 99:2228-2233 (2002)). Thus, in some cases, the methods can include analysis of polymorphisms that are in LD with a polymorphism described herein. Methods are known in the art for identifying such polymorphisms; for example, the International HapMap Project provides a public database that can be used, see hapmap.org, as well as The International HapMap Consortium, Nature 426:789-796 (2003), and The International HapMap Consortium, Nature 437:1299-1320 (2005). Generally, it will be desirable to use a HapMap constructed using data from individuals who share ethnicity with the subject. For example, a HapMap for African Americans would ideally be used to identify markers in LD with an exemplary marker described herein for use in genotyping a subject of African American descent.

[0044] Alternatively, methods described herein can include analysis of polymorphisms that show a correlation coefficient (r²) of value ≧0.5 with the markers described herein. Results can be obtained from on line public resources such as HapMap.org on the World Wide Web. The correlation coefficient is a measure of LD, and reflects the degree to which alleles at two loci (for example, two SNPs) occur together, such that an allele at one SNP position can predict the correlated allele at a second SNP position, in the case where r² is >0.5.

[0045] Identifying Additional Genetic Markers

[0046] In general, genetic markers can be identified using any of a number of methods well known in the art. For example, numerous polymorphisms in the regions described herein are known to exist and are available in public databases, which can be searched using methods and algorithms known in the art. Alternately, polymorphisms can be identified by sequencing either genomic DNA or cDNA in the region in which it is desired to find a polymorphism. According to one approach, primers are designed to amplify such a region, and DNA from a subject is obtained and amplified. The DNA is sequenced, and the sequence (referred to as a "subject sequence" or "test sequence") is compared with a reference sequence, which can represent the "normal" or "wild type" sequence, or the "affected" sequence. In some embodiments, a reference sequence can be from, for example, the human draft genome sequence, publicly available in various databases, or a sequence deposited in a database such as GenBank. In some embodiments, the reference sequence is a composite of ethnically diverse individuals.

[0047] In general, if sequencing reveals a difference between the sequenced region and the reference sequence, a polymorphism has been identified. The fact that a difference in nucleotide sequence is identified at a particular site that determines that a polymorphism exists at that site. In most instances, particularly in the case of SNPs, only two polymorphic variants will exist at any location. However, in the case of SNPs, up to four variants may exist since there are four naturally occurring nucleotides in DNA. Other polymorphisms, such as insertions and deletions, may have more than four alleles.

[0048] The methods described herein can also include determining the presence or absence of other markers known or suspected to be associated with an SSD (e.g., SZ) endophenotype, e.g., markers outside of a region identified herein, see, e.g., Harrison and Owen, Lancet, 361(9355):417-419 (2003). In some embodiments, the methods include determining the presence or absence of one or more other markers that are or may be associated with an SSD (e.g., SZ) endophenotype, e.g., in one or more genes, e.g., e.g., as described in WO 2009/092032, WO 2009/089120, WO 2009/082743, US2006/0177851, and US2009/0012371 incorporated herein in their entirety. See also, e.g., OMIM entry no. 181500 (SCZD).

[0049] Methods of Determining the Identity of an Allele

[0050] The methods described herein include determining the identity, presence or absence of alleles associated with a severity of specific SSD (e.g., SZ) endophenotype. In some cases, an association with severity of an SSD (e.g., SZ) endophenotype is determined by the presence of the same allele in both the subject and an affected reference individual, e.g., in an unrelated reference subject or a first or second-degree relation of the subject, and the absence of the allele in an unaffected reference individual. Thus the methods can include obtaining and analyzing a sample from a suitable reference individual. Samples that are suitable for use in the methods described herein contain genetic material, e.g., genomic DNA (gDNA). Genomic DNA is typically extracted from biological samples such as blood or mucosal scrapings of the lining of the mouth, but can be extracted from other biological samples including urine or expectorant. The sample itself will typically include nucleated cells (e.g., blood or buccal cells) or tissue removed from the subject. The subject can be an adult, child, fetus, or embryo. In some embodiments, the sample is obtained prenatally, either from a fetus or embryo or from the mother (e.g., from fetal or embryonic cells in the maternal circulation). Methods and reagents are known in the art for obtaining, processing, and analyzing samples. In some embodiments, the sample is obtained with the assistance of a health care provider, e.g., to draw blood. In some embodiments, the sample is obtained without the assistance of a health care provider, e.g., where the sample is obtained non-invasively, such as a sample comprising buccal cells that is obtained using a buccal swab or brush, or a mouthwash sample.

[0051] In some cases, a biological sample may be processed for DNA isolation. For example, DNA in a cell or tissue sample can be separated from other components of the sample. Cells can be harvested from a biological sample using standard techniques known in the art. For example, cells can be harvested by centrifuging a cell sample and resuspending the pelleted cells. The cells can be resuspended in a buffered solution such as phosphate-buffered saline (PBS). After centrifuging the cell suspension to obtain a cell pellet, the cells can be lysed to extract DNA, e.g., gDNA. See, e.g., Ausubel et al., 2003, supra. The sample can be concentrated and/or purified to isolate DNA. All samples obtained from a subject, including those subjected to any sort of further processing, are considered to be obtained from the subject. Routine methods can be used to extract genomic DNA from a biological sample, including, for example, phenol extraction. Alternatively, genomic DNA can be extracted with kits such as the QIAamp® Tissue Kit (Qiagen, Chatsworth, Calif.) and the Wizard® Genomic DNA purification kit (Promega). Non-limiting examples of sources of samples include urine, blood, and tissue.

[0052] The absence or presence of an allele associated with severity of an SSD (e.g., SZ) endophenotype as described herein can be determined using methods known in the art. For example, gel electrophoresis, capillary electrophoresis, size exclusion chromatography, sequencing, and/or arrays can be used to detect the presence or absence of the allele. Amplification of nucleic acids, where desirable, can be accomplished using methods known in the art, e.g., PCR. In one example, a sample (e.g., a sample comprising genomic DNA), is obtained from a subject. The DNA in the sample is then examined to determine the identity of an allele as described herein. The identity of the allele can be determined by any method described herein, e.g., by sequencing or by hybridization of the gene in the genomic DNA, RNA, or cDNA to a nucleic acid probe, e.g., a DNA probe (which includes cDNA and oligonucleotide probes) or an RNA probe. The nucleic acid probe can be designed to specifically or preferentially hybridize with a particular polymorphic variant.

[0053] Other methods of nucleic acid analysis can include direct manual sequencing (Church and Gilbert, Proc. Natl. Acad. Sci. USA 81:1991-1995 (1988); Sanger et al., Proc. Natl. Acad. Sci. USA 74:5463-5467 (1977); Beavis et al., U.S. Pat. No. 5,288,644); automated fluorescent sequencing; single-stranded conformation polymorphism assays (SSCP) (Schafer et al., Nat. Biotechnol. 15:33-39 (1995)); clamped denaturing gel electrophoresis (CDGE); two-dimensional gel electrophoresis (2DGE or TDGE); conformational sensitive gel electrophoresis (CSGE); denaturing gradient gel electrophoresis (DGGE) (Sheffield et al., Proc. Natl. Acad. Sci. USA 86:232-236 (1989)); denaturing high performance liquid chromatography (DHPLC, Underhill et al., Genome Res. 7:996-1005 (1997)); infrared matrix-assisted laser desorption/ionization (IR-MALDI) mass spectrometry (WO 99/57318); mobility shift analysis (Orita et al., Proc. Natl. Acad. Sci. USA 86:2766-2770 (1989)); restriction enzyme analysis (Flavell et al., Cell 15:25 (1978); Geever et al., Proc. Natl. Acad. Sci. USA 78:5081 (1981)); quantitative real-time PCR (Raca et al., Genet Test 8(4):387-94 (2004)); heteroduplex analysis; chemical mismatch cleavage (CMC) (Cotton et al., Proc. Natl. Acad. Sci. USA 85:4397-4401 (1985)); RNase protection assays (Myers et al., Science 230:1242 (1985)); use of polypeptides that recognize nucleotide mismatches, e.g., E. coli mutS protein; allele-specific PCR, and combinations of such methods. See, e.g., Gerber et al., U.S. Patent Publication No. 2004/0014095 which is incorporated herein by reference in its entirety.

[0054] Sequence analysis can also be used to detect specific polymorphic variants. For example, polymorphic variants can be detected by sequencing exons, introns, 5' untranslated sequences, or 3' untranslated sequences. A sample comprising DNA or RNA is obtained from the subject. PCR or other appropriate methods can be used to amplify a portion encompassing the polymorphic site, if desired. The sequence is then ascertained, using any standard method, and the presence of a polymorphic variant is determined. Real-time pyrophosphate DNA sequencing is yet another approach to detection of polymorphisms and polymorphic variants (Alderborn et al., Genome Research 10(8):1249-1258 (2000)). Additional methods include, for example, PCR amplification in combination with denaturing high performance liquid chromatography (dHPLC) (Underhill et al., Genome Research 7(10):996-1005 (1997)).

[0055] In order to detect polymorphisms and/or polymorphic variants, it will frequently be desirable to amplify a portion of genomic DNA (gDNA) encompassing the polymorphic site. Such regions can be amplified and isolated by PCR using oligonucleotide primers designed based on genomic and/or cDNA sequences that flank the site. PCR refers to procedures in which target nucleic acid (e.g., genomic DNA) is amplified in a manner similar to that described in U.S. Pat. No. 4,683,195, and subsequent modifications of the procedure described therein. Generally, sequence information from the ends of the region of interest or beyond are used to design oligonucleotide primers that are identical or similar in sequence to opposite strands of a potential template to be amplified. See e.g., PCR Primer: A Laboratory Manual, Dieffenbach and Dveksler, (Eds.); McPherson et al., PCR Basics: From Background to Bench (Springer Verlag, 2000); Mattila et al., Nucleic Acids Res., 19:4967 (1991); Eckert et al., PCR Methods and Applications, 1:17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. No. 4,683,202. Other amplification methods that may be employed include the ligase chain reaction (LCR) (Wu and Wallace, Genomics 4:560 (1989), Landegren et al., Science 241:1077 (1988), transcription amplification (Kwoh et al., Proc. Natl. Acad. Sci. USA 86:1173 (1989)), self-sustained sequence replication (Guatelli et al., Proc. Nat. Acad. Sci. USA 87:1874 (1990)), and nucleic acid based sequence amplification (NASBA). Guidelines for selecting primers for PCR amplification are well known in the art. See, e.g., McPherson et al., PCR Basics: From Background to Bench, Springer-Verlag, 2000. A variety of computer programs for designing primers are available, e.g., `Oligo` (National Biosciences, Inc, Plymouth Minn.), MacVector (Kodak/IBI), and the GCG suite of sequence analysis programs (Genetics Computer Group, Madison, Wis. 53711).

[0056] In some cases, PCR conditions and primers can be developed that amplify a product only when the variant allele is present or only when the wild type allele is present (MSPCR or allele-specific PCR). For example, patient DNA and a control can be amplified separately using either a wild type primer or a primer specific for the variant allele. Each set of reactions is then examined for the presence of amplification products using standard methods to visualize the DNA. For example, the reactions can be electrophoresed through an agarose gel and the DNA visualized by staining with ethidium bromide or other DNA intercalating dye. In DNA samples from heterozygous patients, reaction products would be detected in each reaction.

[0057] Real-time quantitative PCR can also be used to determine copy number. Quantitative PCR permits both detection and quantification of specific DNA sequence in a sample as an absolute number of copies or as a relative amount when normalized to DNA input or other normalizing genes. A key feature of quantitative PCR is that the amplified DNA product is quantified in real-time as it accumulates in the reaction after each amplification cycle. Methods of quantification can include the use of fluorescent dyes that intercalate with double-stranded DNA, and modified DNA oligonucleotide probes that fluoresce when hybridized with a complementary DNA.

[0058] In some embodiments, a peptide nucleic acid (PNA) probe can be used instead of a nucleic acid probe in the hybridization methods described above. PNA is a DNA mimetic with a peptide-like, inorganic backbone, e.g., N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, e.g., Nielsen et al., Bioconjugate Chemistry, The American Chemical Society, 5:1 (1994)). The PNA probe can be designed to specifically hybridize to a nucleic acid comprising a polymorphic variant indicative of an SSD (e.g., SZ) endophenotype.

[0059] In some cases, allele-specific oligonucleotides can also be used to detect the presence of a polymorphic variant. For example, polymorphic variants can be detected by performing allele-specific hybridization or allele-specific restriction digests. Allele specific hybridization is an example of a method that can be used to detect sequence variants, including complete haplotypes of a subject (e.g., a mammal such as a human). See Stoneking et al., Am. J. Hum. Genet. 48:370-382 (1991); and Prince et al., Genome Res. 11:152-162 (2001). An "allele-specific oligonucleotide" (also referred to herein as an "allele-specific oligonucleotide probe") is an oligonucleotide that is specific for particular a polymorphism can be prepared using standard methods (see Ausubel et al., Current Protocols in Molecular Biology, supra). Allele-specific oligonucleotide probes typically can be approximately 10-50 base pairs, preferably approximately 15-30 base pairs, that specifically hybridizes to a nucleic acid region that contains a polymorphism. Hybridization conditions are selected such that a nucleic acid probe can specifically bind to the sequence of interest, e.g., the variant nucleic acid sequence. Such hybridizations typically are performed under high stringency as some sequence variants include only a single nucleotide difference. In some cases, dot-blot hybridization of amplified oligonucleotides with allele-specific oligonucleotide (ASO) probes can be performed. See, for example, Saiki et al., Nature (London) 324:163-166 (1986).

[0060] In some embodiments, allele-specific restriction digest analysis can be used to detect the existence of a polymorphic variant of a polymorphism, if alternate polymorphic variants of the polymorphism result in the creation or elimination of a restriction site. Allele-specific restriction digests can be performed in the following manner. A sample containing genomic DNA is obtained from the individual and genomic DNA is isolated for analysis. For nucleotide sequence variants that introduce a restriction site, restriction digest with the particular restriction enzyme can differentiate the alleles. In some cases, polymerase chain reaction (PCR) can be used to amplify a region comprising the polymorphic site, and restriction fragment length polymorphism analysis is conducted (see Ausubel et al., Current Protocols in Molecular Biology, supra). The digestion pattern of the relevant DNA fragment indicates the presence or absence of a particular polymorphic variant of the polymorphism and is therefore indicative of severity of an SSD endophenotype. For sequence variants that do not alter a common restriction site, mutagenic primers can be designed that introduce a restriction site when the variant allele is present or when the wild type allele is present. For example, a portion of a nucleic acid can be amplified using the mutagenic primer and a wild type primer, followed by digest with the appropriate restriction endonuclease.

[0061] In some embodiments, fluorescence polarization template-directed dye-terminator incorporation (FP-TDI) is used to determine which of multiple polymorphic variants of a polymorphism is present in a subject (Chen et al., Genome Research 9(5):492-498 (1999)). Rather than involving use of allele-specific probes or primers, this method employs primers that terminate adjacent to a polymorphic site, so that extension of the primer by a single nucleotide results in incorporation of a nucleotide complementary to the polymorphic variant at the polymorphic site.

[0062] In some cases, DNA containing an amplified portion may be dot-blotted, using standard methods (see Ausubel et al., Current Protocols in Molecular Biology, supra), and the blot contacted with the oligonucleotide probe. The presence of specific hybridization of the probe to the DNA is then detected. Specific hybridization of an allele-specific oligonucleotide probe to DNA from the subject can be indicative of the presence of an allele associated with an SSD (e.g., SZ) endophenotype.

[0063] The methods can include determining the genotype of a subject with respect to both copies of the polymorphic site present in the genome. For example, the complete genotype may be characterized as -/-, as -/+, or as +/+, where a minus sign indicates the presence of the reference or wild type sequence at the polymorphic site, and the plus sign indicates the presence of a polymorphic variant other than the reference sequence. If multiple polymorphic variants exist at a site, this can be appropriately indicated by specifying which ones are present in the subject. Any of the detection means described herein can be used to determine the genotype of a subject with respect to one or both copies of the polymorphism present in the subject's genome.

[0064] Methods of nucleic acid analysis to detect polymorphisms and/or polymorphic variants can include, e.g., microarray analysis. Hybridization methods, such as Southern analysis, Northern analysis, or in situ hybridizations, can also be used (see Ausubel et al., Current Protocols in Molecular Biology, eds., John Wiley & Sons (2003)). To detect microdeletions, fluorescence in situ hybridization (FISH) using DNA probes that are directed to a putatively deleted region in a chromosome can be used. For example, probes that detect all or a part of a microsatellite marker can be used to detect microdeletions in the region that contains that marker.

[0065] In some embodiments, it is desirable to employ methods that can detect the presence of multiple polymorphisms (e.g., polymorphic variants at a plurality of polymorphic sites) in parallel or substantially simultaneously. Oligonucleotide arrays represent one suitable means for doing so. Other methods, including methods in which reactions (e.g., amplification, hybridization) are performed in individual vessels, e.g., within individual wells of a multi-well plate or other vessel may also be performed so as to detect the presence of multiple polymorphic variants (e.g., polymorphic variants at a plurality of polymorphic sites) in parallel or substantially simultaneously according to the methods provided herein.

[0066] Nucleic acid probes can be used to detect and/or quantify the presence of a particular target nucleic acid sequence within a sample of nucleic acid sequences, e.g., as hybridization probes, or to amplify a particular target sequence within a sample, e.g., as a primer. Probes have a complimentary nucleic acid sequence that selectively hybridizes to the target nucleic acid sequence. In order for a probe to hybridize to a target sequence, the hybridization probe must have sufficient identity with the target sequence, i.e., at least 70% (e.g., 80%, 90%, 95%, 98% or more) identity to the target sequence. The probe sequence must also be sufficiently long so that the probe exhibits selectivity for the target sequence over non-target sequences. For example, the probe will be at least 20 (e.g., 25, 30, 35, 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 or more) nucleotides in length. In some embodiments, the probes are not more than 30, 50, 100, 200, 300, 500, 750, or 1000 nucleotides in length. Probes are typically about 20 to about 1×10⁶ nucleotides in length. Probes include primers, which generally refers to a single-stranded oligonucleotide probe that can act as a point of initiation of template-directed DNA synthesis using methods such as PCR (polymerase chain reaction), LCR (ligase chain reaction), etc., for amplification of a target sequence.

[0067] The probe can be a test probe such as a probe that can be used to detect polymorphisms in a region described herein (e.g., polymorphisms as described herein). In some embodiments, the probe can bind to another marker sequence associated with SZ, SPD, or SD as described herein.

[0068] Control probes can also be used. For example, a probe that binds a less variable sequence, e.g., repetitive DNA associated with a centromere of a chromosome, can be used as a control. Probes that hybridize with various centromeric DNA and locus-specific DNA are available commercially, for example, from Vysis, Inc. (Downers Grove, Ill.), Molecular Probes, Inc. (Eugene, Oreg.), or from Cytocell (Oxfordshire, UK). Probe sets are available commercially such from Applied Biosystems, e.g., the Assays-on-Demand SNP kits Alternatively, probes can be synthesized, e.g., chemically or in vitro, or made from chromosomal or genomic DNA through standard techniques. For example, sources of DNA that can be used include genomic DNA, cloned DNA sequences, somatic cell hybrids that contain one, or a part of one, human chromosome along with the normal chromosome complement of the host, and chromosomes purified by flow cytometry or microdissection. The region of interest can be isolated through cloning, or by site-specific amplification via the polymerase chain reaction (PCR). See, for example, Nath and Johnson, Biotechnic. Histochem. 73(1):6-22 (1998); Wheeless et al., Cytometry 17:319-326 (1994); and U.S. Pat. No. 5,491,224.

[0069] In some embodiments, the probes are labeled, e.g., by direct labeling, with a fluorophore, an organic molecule that fluoresces after absorbing light of lower wavelength/higher energy. A directly labeled fluorophore allows the probe to be visualized without a secondary detection molecule. After covalently attaching a fluorophore to a nucleotide, the nucleotide can be directly incorporated into the probe with standard techniques such as nick translation, random priming, and PCR labeling. Alternatively, deoxycytidine nucleotides within the probe can be transaminated with a linker. The fluorophore then is covalently attached to the transaminated deoxycytidine nucleotides. See, e.g., U.S. Pat. No. 5,491,224.

[0070] Fluorophores of different colors can be chosen such that each probe in a set can be distinctly visualized. For example, a combination of the following fluorophores can be used: 7-amino-4-methylcoumarin-3-acetic acid (AMCA), TEXAS RED® (Molecular Probes, Inc., Eugene, Oreg.), 5-(and-6)-carboxy-X-rhodamine, lissamine rhodamine B, 5-(and-6)-carboxyfluorescein, fluorescein-5-isothiocyanate (FITC), 7-diethylaminocoumarin-3-carboxylic acid, tetramethylrhodamine-5-(and-6)-isothiocyanate, 5-(and-6)-carboxytetramethylrhodamine, 7-hydroxycoumarin-3-carboxylic acid, 6-[fluorescein 5-(and-6)-carboxamido]hexanoic acid, N-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a diaza-3-indacenepropionic acid, eosin-5-isothiocyanate, erythrosin-5-isothiocyanate, and CASCADE® blue acetylazide (Molecular Probes, Inc., Eugene, Oreg.). Fluorescently labeled probes can be viewed with a fluorescence microscope and an appropriate filter for each fluorophore, or by using dual or triple band-pass filter sets to observe multiple fluorophores. See, for example, U.S. Pat. No. 5,776,688. Alternatively, techniques such as flow cytometry can be used to examine the hybridization pattern of the probes. Fluorescence-based arrays are also known in the art.

[0071] In other embodiments, the probes can be indirectly labeled with, e.g., biotin or digoxygenin, or labeled with radioactive isotopes such as ³²P and ³H. For example, a probe indirectly labeled with biotin can be detected by avidin conjugated to a detectable marker. For example, avidin can be conjugated to an enzymatic marker such as alkaline phosphatase or horseradish peroxidase. Enzymatic markers can be detected in standard colorimetric reactions using a substrate and/or a catalyst for the enzyme. Catalysts for alkaline phosphatase include 5-bromo-4-chloro-3-indolylphosphate and nitro blue tetrazolium. Diaminobenzoate can be used as a catalyst for horseradish peroxidase.

[0072] In another aspect, this document features arrays that include a substrate having a plurality of addressable areas, and methods of using them. At least one area of the plurality includes a nucleic acid probe that binds specifically to a sequence comprising a polymorphism listed in any of Tables 1-3, and can be used to detect the absence or presence of said polymorphism, e.g., one or more SNPs, microsatellites, minisatellites, or indels, as described herein, to determine the identity of an allele. For example, the array can include one or more nucleic acid probes that can be used to detect a polymorphism listed in any of Tables 1-3. In some embodiments, the array further includes at least one area that includes a nucleic acid probe that can be used to specifically detect another marker associated with severity of an SSD (e.g., SZ), as described herein. In some embodiments, the probes are nucleic acid capture probes.

[0073] Generally, microarray hybridization is performed by hybridizing a nucleic acid of interest (e.g., a nucleic acid encompassing a polymorphic site) with the array and detecting hybridization using nucleic acid probes. In some cases, the nucleic acid of interest is amplified prior to hybridization. Hybridization and detecting are generally carried out according to standard methods. See, e.g., Published PCT Application Nos. WO 92/10092 and WO 95/11995, and U.S. Pat. No. 5,424,186. For example, the array can be scanned to determine the position on the array to which the nucleic acid hybridizes. The hybridization data obtained from the scan is typically in the form of fluorescence intensities as a function of location on the array.

[0074] Arrays can be formed on substrates fabricated with materials such as paper, glass, plastic (e.g., polypropylene, nylon, or polystyrene), polyacrylamide, nitrocellulose, silicon, optical fiber, or any other suitable solid or semisolid support, and can be configured in a planar (e.g., glass plates, silicon chips) or three dimensional (e.g., pins, fibers, beads, particles, microtiter wells, capillaries) configuration. Methods for generating arrays are known in the art and include, e.g., photolithographic methods (see, e.g., U.S. Pat. Nos. 5,143,854; 5,510,270; and 5,527,681), mechanical methods (e.g., directed-flow methods as described in U.S. Pat. No. 5,384,261), pin-based methods (e.g., as described in U.S. Pat. No. 5,288,514), and bead-based techniques (e.g., as described in PCT US/93/04145). The array typically includes oligonucleotide hybridization probes capable of specifically hybridizing to different polymorphic variants. Oligonucleotide probes that exhibit differential or selective binding to polymorphic sites may readily be designed by one of ordinary skill in the art. For example, an oligonucleotide that is perfectly complementary to a sequence that encompasses a polymorphic site (i.e., a sequence that includes the polymorphic site, within it or at one end) will generally hybridize preferentially to a nucleic acid comprising that sequence, as opposed to a nucleic acid comprising an alternate polymorphic variant.

[0075] Oligonucleotide probes forming an array may be attached to a substrate by any number of techniques, including, without limitation, (i) in situ synthesis (e.g., high-density oligonucleotide arrays) using photolithographic techniques; (ii) spotting/printing at medium to low density on glass, nylon or nitrocellulose; (iii) by masking, and (iv) by dot-blotting on a nylon or nitrocellulose hybridization membrane. Oligonucleotides can be immobilized via a linker, including by covalent, ionic, or physical linkage. Linkers for immobilizing nucleic acids and polypeptides, including reversible or cleavable linkers, are known in the art. See, for example, U.S. Pat. No. 5,451,683 and WO98/20019. Alternatively, oligonucleotides can be non-covalently immobilized on a substrate by hybridization to anchors, by means of magnetic beads, or in a fluid phase such as in microtiter wells or capillaries. Immobilized oligonucleotide probes are typically about 20 nucleotides in length, but can vary from about 10 nucleotides to about 1000 nucleotides in length.

[0076] Arrays can include multiple detection blocks (i.e., multiple groups of probes designed for detection of particular polymorphisms). Such arrays can be used to analyze multiple different polymorphisms. Detection blocks may be grouped within a single array or in multiple, separate arrays so that varying conditions (e.g., conditions optimized for particular polymorphisms) may be used during the hybridization. For example, it may be desirable to provide for the detection of those polymorphisms that fall within G-C rich stretches of a genomic sequence, separately from those falling in A-T rich segments. General descriptions of using oligonucleotide arrays for detection of polymorphisms can be found, for example, in U.S. Pat. Nos. 5,858,659 and 5,837,832. In addition to oligonucleotide arrays, cDNA arrays may be used similarly in certain embodiments.

[0077] The methods described herein can include providing an array as described herein; contacting the array with a sample (e.g., all or a portion of genomic DNA that includes at least a portion of a human chromosome comprising a response allele) and/or optionally, a different portion of genomic DNA (e.g., a portion that includes a different portion of one or more human chromosomes), and detecting binding of a nucleic acid from the sample to the array. Optionally, the method includes amplifying nucleic acid from the sample, e.g., genomic DNA that includes a portion of a human chromosome described herein, and, optionally, a region that includes another region associated with a diagnosis of an SSD, severity of an SZ endophenotype, or a predicted response to a method of treating SZ, SD, or SPD, prior to or during contact with the array.

[0078] In some aspects, the methods described herein can include using an array that can ascertain differential expression patterns or copy numbers of one or more genes in samples from normal and affected individuals (see, e.g., Redon et al., Nature 444(7118):444-54 (2006)). For example, arrays of probes to a marker described herein can be used to measure polymorphisms between DNA from a subject having a known severity of an SSD (e.g., SZ) endophenotype, and control DNA, e.g., DNA obtained from an individual that does not have an SSD (e.g., SZ) endophenotype, or has a different severity of the SSD (e.g., SZ) endophenotype. Since the clones on the array contain sequence tags, their positions on the array are accurately known relative to the genomic sequence. Different hybridization patterns between DNA from an individual afflicted with a severe SSD (e.g., SZ) endophenotype and DNA from a normal individual (or an individual with SZ not displaying the endophenotype, or displaying a more or less severe degree of the endophenotype) at areas in the array corresponding to markers as described herein, indicate the severity of the endophenotype. Methods for array production, hybridization, and analysis are described, e.g., in Snijders et al., Nat. Genetics 29:263-264 (2001); Klein et al., Proc. Natl. Acad. Sci. USA 96:4494-4499 (1999); Albertson et al., Breast Cancer Research and Treatment 78:289-298 (2003); and Snijders et al., "BAC microarray based comparative genomic hybridization," in: Zhao et al. (eds), Bacterial Artificial Chromosomes: Methods and Protocols, Methods in Molecular Biology, Humana Press, 2002.

[0079] In another aspect, this document provides methods of determining the absence or presence of one or more alleles associated with severity of an SSD (e.g., SZ) endophenotype as described herein, using an array described above. The methods can include providing a two dimensional array having a plurality of addresses, each address of the plurality being positionally distinguishable from each other address of the plurality having a unique nucleic acid capture probe, contacting the array with a first sample from a test subject, and comparing the binding of the first sample with one or more references, e.g., binding of a sample from a subject who has a known severity of an SSD (e.g., SZ) endophenotype, and/or binding of a sample from a subject who has a different known severity of the endophenotype, e.g., is unaffected, e.g., a control sample from a subject who has SZ but displays the endophenotype to a more or less severe degree. In some embodiments, the methods can include contacting the array with a second sample from a subject who has a known severity of an SSD (e.g., SZ) endophenotype; and comparing the binding of the first sample with the binding of the second sample. In some embodiments, the methods can include contacting the array with a third sample from a cell or subject that does not display an SSD (e.g., SZ) endophenotype (e.g., a low score); and comparing the binding of the first sample with the binding of the third sample. In some embodiments, the second and third samples are from first or second-degree relatives of the test subject. In the case of a nucleic acid hybridization, binding with a capture probe at an address of the plurality, can be detected by any method known in the art, e.g., by detection of a signal generated from a label attached to the nucleic acid.

Schizophrenia Spectrum Disorders

[0080] The methods described herein can be used to determine severity of an endophenotype of a schizophrenia spectrum disorder (SSD) in an individual diagnosed with the SSD. The SSDs include schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). Methods for diagnosing SSDs are known in the art, see, e.g., the Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition ("DSM-IV"). See, e.g., WO 2009/092032, incorporated herein by reference.

Psychiatric Endophenotypes

[0081] A number of endophenotypes, i.e., intermediate phenotypes, that may more closely reflect biological mechanisms behind SZ, have been suggested, such as prepulse inhibition, structural abnormalities evident in MRI scans, specific domains of cognition (e.g., executive function), fine motor performance, and working memory, inter alia.

[0082] Endophenotypes also can include clinical manifestations such as hallucinations, paranoia, mania, depression, obsessive-compulsive symptoms, etc., as well as response or lack of response to drugs and comorbidity for substance and alcohol abuse. See, e.g., Kendler et al., Am J Psychiatry 152(5):749-54 (1995); Gottesman and Gould, Am J Psychiatry 160(4):636-45 (2003); Cadenhead, Psychiatric Clinics of North America 25(4):837-53 (2002); Heinrichs, Neuroscience & Biobehavioral Reviews 28(4):379-94 (2004); and Zobel and Maier, Nervenarzt. 75(3):205-14 (2004). There is now evidence that some candidate genes that were identified using DSM-IV type categorical definitions for "affected" individuals may influence specific endophenotypes, see, e.g., Baker et al., Biol Psychiatry 58(1):23-31 (2005); Cannon et al., Arch Gen Psychiatry 62(11):1205-13 (2005); Gothelf et al., Nat Neurosci 8(11):1500-2 (2005); Hallmayer et al., Am J Hum Genet. 77(3):468-76 (2005); Callicott et al., Proc Natl Acad Sci USA 102(24):8627-32 (2005); Gornick et al., J Autism Dev Disord 1-8 (2005). Thus, the methods described herein can be used to associate alleles with specific psychiatric endophenotypes.

[0083] Positive and Negative Syndrome Scale (PANSS)

[0084] The Positive and Negative Syndrome Scale (PANSS) is a comprehensive psychometric scale used to classify psychopathology for severe neuropsychiatric diseases, including SZ. It measures a number of psychiatric endophenotypes or dimensions using quantitative scales based on the scoring of patients by clinicians. It is widely used to classify patients into specific subtypes, and is commonly used for measuring the improvement of symptoms in response to clinical interventions (Kay et al., Schizophr. Bull. 13:261-276 (1987); Kay et al., Br. J. Psychiatry Suppl 59-67 (1989); Leucht et al., Schizophr. Res. 79:231-238 (2005)).

[0085] PANSS comprises 30 individual subscales. Seven constitute a Positive Symptom Scale, seven make up a Negative Symptom Scale, and the remaining 16 items make up a General Psychopathology Scale. The scores for these scales are arrived at by summation of ratings across component items. Therefore, the potential ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale (Source: The PANSS Institute). Detailed information on PANSS and Scoring Criteria can be found at www.panss.org or in the book Positive and Negative Syndromes in Schizophrenia, Stanley R. Kay, 1991, ISBN: 978-0-87630-608-6, Routledge, which is incorporated herein in its entirety by reference. Based on these sources, the methodology is summarized briefly below.

[0086] Each of the 30 items is accompanied by a specific definition as well as detailed anchoring criteria for all seven rating points. These seven points represent increasing levels of psychopathology, as follows:

[0087] 1--absent

[0088] 2--minimal

[0089] 3--mild

[0090] 4--moderate

[0091] 5--moderate severe

[0092] 6--severe

[0093] 7--extreme

The individual PANSS Individual subcales are described below.

[0094] P1. DELUSIONS--Beliefs which are unfounded, unrealistic and idiosyncratic.

[0095] P2. CONCEPTUAL DISORGANIZATION--Disorganized process of thinking characterized by disruption of goal-directed sequencing, e.g. circumstantiality, loose associations, tangentiality, gross illogicality or thought block.

[0096] P3. HALLUCINATORY BEHAVIOR--Verbal report or behavior indicating perceptions which are not generated by external stimuli. These may occur in the auditory, visual, olfactory or somatic realms.

[0097] P4. EXCITEMENT--Hyperactivity as reflected in accelerated motor behavior, heightened responsivity to stimuli, hypervigilance or excessive mood lability.

[0098] P5. GRANDIOSITY--Exaggerated self-opinion and unrealistic convictions of superiority, including delusions of extraordinary abilities, wealth, knowledge, fame, power and moral righteousness.

[0099] P6. SUSPICIOUSNESS/PERSECUTION--Unrealistic or exaggerated ideas of persecution, as reflected in guardedness, ad distrustful attitude, suspicious hypervigilance or frank delusions that others mean harm.

[0100] P7. HOSTILITY--Verbal and nonverbal expressions of anger and resentment, including sarcasm, passive-aggressive behavior, verbal abuse and assualtiveness.

[0101] N1. BLUNTED AFFECT--Diminished emotional responsiveness as characterized by a reduction in facial expression, modulation of feelings and communicative gestures.

[0102] N2. EMOTIONAL WITHDRAWAL--Lack of interest in, involvement with, and affective commitment to life's events.

[0103] N3. POOR RAPPORT--Lack of interpersonal empathy, openness in conversation and sense of closeness, interest or involvement with the interviewer. This is evidenced by interpersonal distancing and reduced verbal and nonverbal communication.

[0104] N4. PASSIVE/APATHETIC SOClAL WITHDRAWAL--Diminished interest and initiative in social interactions due to passivity, apathy, anergy or avolition. This leads to reduced interpersonal involvements and neglect of activities of daily living.

[0105] N5. DIFFICULTY IN ABSTRACT THINKING--Impairment in the use of the abstract-symbolic mode of thinking, as evidenced by difficulty in classification, forming generalizations and proceeding beyond concrete or egocentric thinking in problem-solving tasks.

[0106] N6. LACK OF SPONTANEITY AND FLOW OF CONVERSATION--Reduction in the normal flow of communication associated with apathy, avolition, defensiveness or cognitive deficit. This is manifested by diminished fluidity and productivity of the verbal interactional process.

[0107] N7. STEREOTYPED THINKING--Decreased fluidity, spontaneity and flexibility of thinking, as evidenced in rigid, repetitious or barren thought content.

[0108] G1. SOMATIC CONCERN--Physical complaints or beliefs about bodily illness or malfunctions. This may range from a vague sense of ill being to clear-cut delusions of catastrophic physical disease.

[0109] G2. ANXIETY--Subjective experience of nervousness, worry, apprehension or restlessness, ranging from excessive concern about the present or future to feelings of panic.

[0110] G3. GUILT FEELINGS--Sense of remorse or self-blame for real or imagined misdeeds in the past.

[0111] G4. TENSION--Overt physical manifestations of fear, anxiety, and agitation, such as stiffness, tremor, profuse sweating and restlessness.

[0112] G5. MANNERISMS AND POSTURING--Unnatural movements or posture as characterized be an awkward, stilted, disorganized, or bizarre appearance.

[0113] G6. DEPRESSION--Feelings of sadness, discouragement, helplessness and pessimism.

[0114] G7. MOTOR RETARDATION--Reduction in motor activity as reflected in slowing or lessening or movements and speech, diminished responsiveness of stimuli, and reduced body tone.

[0115] G8. UNCOOPERATIVENESS--Active refusal to comply with the will of significant others, including the interviewer, hospital staff or family, which may be associated with distrust, defensiveness, stubbornness, negativism, rejection of authority, hostility or belligerence.

[0116] G9. UNUSUAL THOUGHT CONTENT--Thinking characterized by strange, fantastic or bizarre ideas, ranging from those which are remote or atypical to those which are distorted, illogical and patently absurd.

[0117] G10. DISORIENTATION--Lack of awareness of one's relationship to the milieu, including persons, place and time, which may be due to confusion or withdrawal.

[0118] G11. POOR ATTENTION--Failure in focused alertness manifested by poor concentration, distractibility from internal and external stimuli, and difficulty in harnessing, sustaining or shifting focus to new stimuli.

[0119] G12. LACK OF JUDGMENT AND INSIGHT--Impaired awareness or understanding of one's own psychiatric condition and life situation. This is evidenced by failure to recognize past or present psychiatric illness or symptoms, denial of need for psychiatric hospitalization or treatment, decisions characterized by poor anticipation or consequences, and unrealistic short-term and long-range planning.

[0120] G13. DISTURBANCE OF VOLITION--Disturbance in the willful initiation, sustenance and control of one's thoughts, behavior, movements and speech.

[0121] G14. POOR IMPULSE CONTROL--Disordered regulation and control of action on inner urges, resulting in sudden, unmodulated, arbitrary or misdirected discharge of tension and emotions without concern about consequences.

[0122] G15. PREOCCUPATION--Absorption with internally generated thoughts and feelings and with autistic experiences to the detriment of reality orientation and adaptive behavior.

[0123] G16. ACTIVE SOClAL AVOIDANCE--Diminished social involvement associated with unwarranted fear, hostility, or distrust.

Differential Diagnosis and Optimizing Treatment

[0124] Each patient's disease manifestation and process is unique. PANSS provides a structured, objective way of describing the various aspects of psychopathology of a given patient. However, proper implementation of the PANSS requires highly trained personnel to conduct the assessment and to interpret the results, and there is potential for site to site variability, especially outside the research setting. Additionally, PANSS does not allow one to determine genetic (or biological) vs. environmental contributions to psychopathology, or which of the many possible genetic contributions are relevant to a particular patient.

[0125] Each of the PANSS composite scales and subscales can be considered a clinical endophenotype. The ability to link genetic profiles to these clinical endophenotypes, as described herein, will enable clinicians to refine a patient's diagnosis and develop a personalized therapeutic strategy for each patient. For example, the C allele of rs3096489, located in the COL25A1 gene, is associated with increased in the Negative Symptom of Increased Difficulty with Abstract Thinking as shown in the regression analysis in Table 2. By identifying these genetic contributions to specific endophenotypes, the physician can create a personalized diagnosis and treatment regime for the patient.

[0126] Results of the methods described herein (e.g., identifying a specific allele in a subject), and optionally interpretive information, can be returned to the subject, the health care provider or to a third party payor. The results can be provided, e.g., in the form of a report; thus, the methods can include preparing a report comprising the results of a method described herein, and identifying information regarding the subject, and optionally interpretive information (e.g., information regarding the association of the allele present in the subject with a particular endophenotype).

[0127] The results can be used in a number of ways. The information can be, e.g., communicated to the tested subject, e.g., with a diagnosis/prognosis and optionally interpretive materials that help the subject understand the test results and diagnosis/prognosis. The information can be used, e.g., by a health care provider, to determine whether a subject should be assigned to a specific category (e.g., a category associated with a specific disease endophenotype). The information can be used, e.g., by a third party payor such as a healthcare payer (e.g., insurance company or HMO) or other agency, to determine whether or not to reimburse a health care provider for services to the subject, or whether to approve the provision of services to the subject. For example, the healthcare payer may decide to reimburse a health care provider for treatments for SZ, SD, or SPD if the subject has an allele associated with a particular severity of an SSD endophenotype. In some embodiments, the results are used by a health care provider to select, change, or optimize treatment for the subject.

[0128] The addition of a genotype/allele profile which details a patient's individual predicted increased or decreased symptom burden for endophenotypes can provide the treating physician with valuable information required to create an enhanced, personalized treatment regimen for the patient. Thus, the methods described herein can be used to select an antipsychotic medication for the subject, according to treatment and clinical methods known in the art. For example, the methods can include selecting clozapine for positive symptom endophenotypes; quetiapine for subjects with hostility and aggression endophenotypes; olanzapine, clozapine, or amilsupride for negative symptom endophenotypes; and glutamate receptor modulators (several are presently in Phase III clinical trials) for cognitive endophenotypes.

[0129] Standard treatment regimens for the majority of patients diagnosed as having SZ typically include polypharmacy. See Pickar et al., PLoS ONE 3(9):e3150 (2008). Physicians often add antidepressants, mood stabilizers, and anti-anxiety medications to the customary treatment with antipsychotics. Additionally, non-medication based therapies such as electroconvulsive shock and cognitive behavioral therapy augment the drug treatment. Thus, in addition, the identification of endophenotypes by a method described herein can be used as an objective criterion to optimize selection of a second drug for administration to the subject. For example, if a patient's allele equates to a reference allele that indicates a likely increased burden for depression, the treating physician might choose to augment antipsychotic therapy with antidepressants. Similarly, an allele that indicates increased symptom burden of mania would suggest that the physician add a mood stabilizer to the patient's drug regimen. An allele associated with disorientation, inattention, lack of judgment or insight, preoccupation, or poor impulse control would indicate administration of a drug for ADHD, e.g., a non-stimulant (such as Atomoxetine (Strattera) or modafinil) or a stimulant, e.g., amphetamine methylphenidate (Ritalin, Metadate, Concerta), dextroamphetamine (Dexedrine), mixed amphetamine salts (Adderall), dextromethamphetamine (Desoxyn) or lisdexamfetamine (Vyvanse). Additional exemplary choices of drugs to be used in addition to an antipsychotic for treating a subject identified as having a specific endophenotype are shown below in Table 4. Changes in a patient's PANSS score and clinical endophenotype can be evaluated following the addition or subtraction of medications or non-medication based therapies with the goal of optimizing treatment for that patient. See, e.g., Chung et al., World J Biol Psychiatry 10(2):156-62 (2009); Hori et al., World J Biol Psychiatry August 25 E-Pub:1-5 (2009); Lipkovich et al., BMC Psychiatry 9:44 (2009); Hwang et al., Int Clin Psychopharmacol 24(4):189-98 (2009).

TABLE-US-00001 TABLE 4 Example Treatments for Specific Endophenotypes, e.g., in Combination with Anti-Psychotics Example Drug PANSS Item Treatment/Drug Class Trade name Generic name P1--delusions Cognitive Behavioral Therapy (CBT) P2--conceptual disorganization CBT P3--hallucinatory behavior CBT P4--exitement Mood stabilizer lithium, valproate, lamotrigine P5--grandiosity Mood stabilizer lithium, valproate, lamotrigine P6--suspiciousness Anti-anxiety benzodiazepines P7--hostility Anti-anxiety benzodiazepines N1--blunted affect SSRI Prozac Fluoxetine NMDA-R glycine, d- agonists cycloserine, and d-serine N2--emotional withdrawal SSRI Prozac Fluoxetine NMDA-R glycine, d- agonists cycloserine, and d-serine N3--poor rapport SSRI Prozac Fluoxetine NMDA-R glycine, d- agonists cycloserine, and d-serine N4--passive/appathetic SSRI Prozac Fluoxetine social withdrawal NMDA-R glycine, d- agonists cycloserine, and d-serine N5--difficulty in abstract thinking NMDA-R glycine, d- agonists cycloserine, and d-serine N6--lack of spontaneity and NMDA-R glycine, d- flow of conversation agonists cycloserine, and d-serine N7--stereotyped thinking NMDA-R glycine, d- agonists cycloserine, and d-serine G1--somatic concern SNRI Cymbalta duloxetine G2--anxiety Anti-anxiety benzodiazepines G3--guilt feelings SSRI Prozac fluoxetine G4--tension Mood stabilizer lithium, valproate, lamotrigine G5--mannerisms and posturing Mood stabilizer lithium, valproate, lamotrigine G6--depression SSRI Prozac Fluoxetine G7--motor retardation Dopaminergics G8--uncooperativeness Levomepromazine G9--unusual thought content CBT G10--disorentation ADHD Stratera, atomoxetine, treatment Ritalin methylphenidate G11--poor attention ADHD Stratera, atomoxetine, treatment; Ritalin methylphenidate cholinesterase inhibitors G12--lack of judgment and insight ADHD Stratera, atomoxetine, treatment; Ritalin methylphenidate cholinesterase inhibitors G13--disturbance of volition cholinesterase inhibitors G14--poor impulse control ADHD Stratera, atomoxetine, treatment; Ritalin methylphenidate beta-blockers lithium, valproate, mood stabilizers, lamotrigine G15--preoccupation ADHD Stratera, atomoxetine, treatment; Ritalin methylphenidate cholinesterase inhibitors G16--active social avoidance. CBT; cholinesterase inhibitors SSRI = selective serotonin reuptake inhibitors SNRI = serotonin-norepinephrine reuptake inhibitor ADHD = attention deficit hyperactivity disorder

[0130] In some cases, a medical or research professional can assess whether a subject has an allele contributing to a clinical endophenotype according to the methods provided herein. Medical professionals can be, for example, doctors, nurses, medical laboratory technologists, and pharmacists. Research professionals can be, for example, principle investigators, research technicians, postdoctoral trainees, and graduate students. A professional can be assisted by (1) determining whether specific polymorphic variants are present in a biological sample from a subject, and (2) communicating information about polymorphic variants to that professional.

[0131] Using information about specific polymorphic variants obtained using a method described herein, a medical professional can take one or more actions that can affect patient care. For example, a medical professional can record information in the patient's medical record regarding the presence or absence of an SSD (e.g., SZ) endophenotype. In some cases, a medical professional can record information regarding an SSD (e.g., SZ) endophenotype, or otherwise transform the patient's medical record, to reflect the patient's current medical condition. In some cases, a medical professional can review and evaluate a patient's entire medical record and assess multiple treatment strategies for clinical intervention of a patient's condition.

[0132] In some cases, a medical professional can initiate or modify treatment after receiving genetic information regarding endophenotype. In some cases, a medical professional can recommend a change in therapy. In some cases, a medical professional can enroll a patient in a clinical trial for, by way of example, detecting correlations between an allele as described herein and any measurable or quantifiable parameter relating to an endophenotype as described above.

[0133] A medical professional can communicate information regarding severity of an SSD (e.g., SZ) endophenotype to a patient or a patient's family. In some cases, a medical professional can provide a patient and/or a patient's family with information regarding SSDs and severity of endophenotype information, including treatment options, prognosis, and referrals to specialists. In some cases, a medical professional can provide a copy of a patient's medical records to a specialist.

[0134] A research professional can apply information regarding the presence of alleles associated with a severity of an SSD (e.g., SZ) endophenotype in a subject to advance scientific research. For example, a researcher can compile data on specific polymorphic variants. In some cases, a research professional can obtain information regarding the identity of an allele associated with a specific endophenotype in a subject as described herein to evaluate a subject's enrollment, or continued participation, in a research study or clinical trial. In some cases, a research professional can communicate information regarding a subject's alleles associated with severity of an SSD (e.g., SZ) endophenotype to a medical professional. In some cases, a research professional can refer a subject to a medical professional.

[0135] Any appropriate method can be used to communicate information to another person (e.g., a professional). For example, information can be given directly or indirectly to a professional. For example, a laboratory technician can input a patient's polymorphic variant alleles as described herein into a computer-based record. In some cases, information is communicated by making a physical alteration to medical or research records. For example, a medical professional can make a permanent notation or flag a medical record for communicating the risk assessment to other medical professionals reviewing the record. In addition, any type of communication can be used to communicate allelic, genotypic, severity of endophenotype, and/or treatment information. For example, mail, e-mail, telephone, and face-to-face interactions can be used. The information also can be communicated to a professional by making that information electronically available to the professional. For example, the information can be communicated to a professional by placing the information on a computer database such that the professional can access the information. In addition, the information can be communicated to a hospital, clinic, or research facility serving as an agent for the professional.

Articles of Manufacture

[0136] Also provided herein are articles of manufacture comprising a probe that hybridizes with a region of human chromosome as described herein and can be used to detect a polymorphism described herein. For example, any of the probes for detecting polymorphisms described herein can be combined with packaging material to generate articles of manufacture or kits. The kit can include one or more other elements including: instructions for use; and other reagents such as a label or an agent useful for attaching a label to the probe. Instructions for use can include instructions for diagnostic applications of the probe for assessing the severity of an SSD (e.g., SZ) endophenotype in a method described herein. Other instructions can include instructions for attaching a label to the probe, instructions for performing in situ analysis with the probe, and/or instructions for obtaining a sample to be analyzed from a subject. In some cases, the kit can include a labeled probe that hybridizes to a region of human chromosome as described herein.

[0137] The kit can also include one or more additional reference or control probes that hybridize to the same chromosome or another chromosome or portion thereof that can have an abnormality associated with a particular endophenotype. A kit that includes additional probes can further include labels, e.g., one or more of the same or different labels for the probes. In other embodiments, the additional probe or probes provided with the kit can be a labeled probe or probes. When the kit further includes one or more additional probe or probes, the kit can further provide instructions for the use of the additional probe or probes. Kits for use in self-testing can also be provided. Such test kits can include devices and instructions that a subject can use to obtain a biological sample (e.g., buccal cells, blood) without the aid of a health care provider. For example, buccal cells can be obtained using a buccal swab or brush, or using mouthwash.

[0138] Kits as provided herein can also include a mailer (e.g., a postage paid envelope or mailing pack) that can be used to return the sample for analysis, e.g., to a laboratory. The kit can include one or more containers for the sample, or the sample can be in a standard blood collection vial. The kit can also include one or more of an informed consent form, a test requisition form, and instructions on how to use the kit in a method described herein. Methods for using such kits are also included herein. One or more of the forms (e.g., the test requisition form) and the container holding the sample can be coded, for example, with a bar code for identifying the subject who provided the sample.

Databases and Reports

[0139] Also provided herein are databases that include a list of polymorphisms as described herein, and wherein the list is largely or entirely limited to polymorphisms identified as useful for determining severity of an SSD (e.g., SZ) endophenotype as described herein. The list is stored, e.g., on a flat file or computer-readable medium. The databases can further include information regarding one or more subjects, e.g., whether a subject is affected or unaffected, clinical information such as endophenotype, age of onset of symptoms, any treatments administered and outcomes (e.g., data relevant to pharmacogenomics, diagnostics or theranostics), and other details, e.g., about the disorder in the subject, or environmental or other genetic factors. The databases can be used to detect correlations between a particular severity of an SSD (e.g., SZ) endophenotype and the information regarding the subject.

[0140] The methods described herein can also include the generation of reports, e.g., for use by a patient, care giver, payor, or researcher, that include information regarding a subject's response allele(s), and optionally further information such as treatments administered, treatment history, medical history, predicted response, and actual response. The reports can be recorded in a tangible medium, e.g., a computer-readable disk, a solid state memory device, or an optical storage device.

[0141] Engineered Cells and Methods of Screening

[0142] Also provided herein are engineered cells that harbor one or more polymorphism described herein, e.g., one or more polymorphisms associated with severity of one or more SSD (e.g., SZ) endophenotypes. Such cells are useful for studying the effect of a polymorphism on physiological function, and for identifying and/or evaluating potential therapeutic agents such as anti-psychotics for the treatment of specific SSD endophenotypes. Methods of using such cells to identify candidate therapeutics for the treatment of SZ are known in the art, e.g., contacting the cells with a test compound and assaying for an effect of the test compound on the cell. The methods can also include detecting an effect of a polymorphism described herein on the activity or levels of a gene or protein associated with that polymorphism, to identify a target for therapeutics.

[0143] As one example, included herein are cells in which one of the various alleles of the genes described herein has be re-created that is associated with a particular severity of an SSD (e.g., SZ) endophenotype. Methods are known in the art for generating cells, e.g., by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell, e.g., a cell of an animal. In some cases, the cells can be used to generate transgenic animals using methods known in the art.

[0144] The cells are preferably mammalian cells (e.g., neuronal type cells) in which an endogenous gene has been altered to include a polymorphism as described herein. Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, U.S. Pat. No. 5,272,071; WO 91/06667, published in May 16, 1991.

EXAMPLES

[0145] The invention is further described in the following examples, which do not limit the scope of the invention described in the claims.

Example 1

Novel Markers Associated with Overall Psychiatric Endophenotypes in SZ

[0146] The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), a large federally funded clinical trial designed to assess the efficacy of antipsychotics in a real world setting, is a valuable resource for determining the role of genes in drug response (Stroup et al., Schizophr. Bull. 29:15-31 (2003); Lieberman et al., N. Engl. J. Med. 353:1209-1223 (2005)). As part of the CATIE trial, SNP genotyping was performed for roughly half of the trial participants (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)). When combined with disease status, PANSS scores, and clinical drug response data, the genotyping data allows the identification of genetic variants (e.g., SNPs) that are statistically associated with specific endophenotypes.

[0147] The design of the CATIE study has been described in detail by others (see, e.g., Stroup et al., Schizophr. Bull. 29:15-31 (2003); Lieberman et al., N. Engl. J. Med. 353:1209-1223 (2005)). Briefly, 1460 subjects were randomly assigned one of several antipsychotics and those who did not respond or chose to quit their current medication were re-randomized to another drug. Details regarding SNP genotyping and quality control have been recently published (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)).

[0148] Genotype and phenotype data for the CATIE trial were made available to qualified researchers through the NIMH Center for Collaborative Genetic Studies on Mental Disorders. Data for 417 patients with schizophrenia and 419 unaffected controls self reported as having exclusively European ancestry were evaluated. This same patient population was described in a recent study by Sullivan and coworkers, which confirmed that there is no hidden stratification in the sample (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)).

[0149] For the CATIE study, individual cases were diagnosed as having SZ based on DSM-III/IV criteria.

[0150] Confirmation of SNP Effects on Psychiatric Endophenotypes

[0151] Genotype and PANSS phonotype data were evaluated for 417 SZ patients enrolled in the CATIE trial. Following a period of drug wash-out, the CATIE study investigators rated each participant at baseline for psychopathology using the PANSS.

[0152] Each of the individual and composite scores is a quantitative trait that can be assessed using quantitative statistical genetics methods. Genetic analysis to determine the influence of haplotypes on quantitative PANSS values was performed using the PLINK 1.03 whole genome analysis toolset developed by Purcell and coworkers (Purcell et al., Am. J. Hum. Genet. 81:559-575 (2007). For dichotomous values, PLINK calculates P values for the allele-specific chi-squared test and the odds ratio (OR; or relative risk) associated with the minor allele. For quantitative values, PLINK performs a linear regression using an additive model for the minor allele.

[0153] Tables 1-3 report results for specific SNP alleles that affect quantitative endophenotypes for SZ, along with Beta values and P values for the particular alleles of SNPs listed therein. The Beta, beta weight from the regression, measures the impact of the SNP allele on the particular scale. A positive Beta means that the allele for the test SNP increases the score for that measure of psychopathology by the stated Beta value, while a negative Beta means that the allele for the test SNP decreases the score that for that measure of psychopathology by the stated Beta value.

[0154] Table 1 shows selected examples for PANSS Total score, and Table 2 shows selected examples for Positive Symptoms subscale, Negative Symptoms subscale, and the General Psychopathology subscale, analyzed as quantitative traits in PLINK using linear regression.

[0155] Table 3 shows selected examples for the individual PANSS components. The component evaluated in each row is identified by one of the following abbreviations: Positive Symptoms: P1--delusions, P2--conceptual disorganization, P3--hallucinatory behavior, P4--exitement, P5--grandiosity, P6--suspiciousness, P7--hostility; Negative Symptoms: N1--blunted affect, N2--emotional withdrawal, N3--poor rapport, N4--passive/appathetic social withdrawal, N5--difficulty in abstract thinking, N6--lack of spontaneity and flow of conversation, N7--steryotyped thinking; General Psychopathology Symptoms: G1--somatic concern, G2--anxiety, G3--guilt feelings, G4--tension, G5--mannerisms and posturing, G6--depression, G7--motor retardation, G8--uncooperativeness, G9--unusual thought content, G10--disorentation, G11--poor attention, G12--lack of judgment and insight, G13 disturbance of volition, G14--poor impulse control, G15-preoccupation, G16--active social avoidance.

[0156] Table A lists the chromosome and position for each SNP, by SEQ ID NO.; the genomic position is relative to NCBI Human Genome Reference Assembly Build 36.3.

Other Embodiments

[0157] It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

TABLE-US-00002 TABLE 1 Alleles Influencing Total PANSS Sequence NCBI Gene ID RS # Allele Beta P KIF1B 3 1555849 G 2.66 0.0467 CGN 16 1547832 A -3.95 0.0421 RALGPS2 32 12076230 G -3.02 0.0169 USH2A 42 7548730 C 2.92 0.0239 RYR2 66 2779400 A -2.62 0.0355 CHRM3 69 16838637 G 2.40 0.0397 FMN2 86 10926257 T 5.23 0.0181 AGBL4-C1ORF165 91 319965 A 2.78 0.0262 SCP2 98 3766762 C -6.05 0.0383 ELTD1 100 17102632 T 3.37 0.0425 HPCAL1 105 16856020 T 4.55 0.0102 NTSR2 108 4669767 C -2.99 0.0158 RAB3GAP1 112 16831315 C 4.04 0.0490 KYNU 130 10176234 A 2.57 0.0375 ARHGAP15 141 13031917 C 2.65 0.0353 FMNL2 144 2164402 G -3.03 0.0327 KCNJ3 149 2961962 C -2.71 0.0244 PKP4 158 2528582 G -3.43 0.0072 PKP4 159 2711072 C 2.73 0.0354 SCN3A 165 11677254 C -3.94 0.0018 SCN9A 169 7589835 A 4.64 0.0134 PDE1A 177 13400054 C -3.25 0.0367 PDE1A 190 9332425 T -2.50 0.0493 NRP2 203 955395 T -3.37 0.0064 NRP2 205 6435306 A -2.70 0.0272 PIP5K3 207 10497899 T -9.28 0.0055 SAG 220 2304773 A 5.04 0.0106 SAG 221 894100 A 2.74 0.0406 KLHL29 225 6727901 G -2.60 0.0383 KLHL29 227 7560892 A -2.50 0.0392 KCNK3 228 7584568 G -2.55 0.0404 DPYSL5 231 540490 T 2.63 0.0320 DPYSL5 232 3769138 G 2.47 0.0442 SLC8A1 246 417614 A 2.70 0.0427 SLC8A1 247 2072531 T -2.48 0.0411 SLC8A1 248 417591 G 3.06 0.0352 SLC8A1 249 11885401 C 3.92 0.0329 PLEKHH2 254 2288710 C 5.00 0.0393 C2ORF34 261 1067378 A -3.54 0.0120 C2ORF34 264 1067402 T -3.20 0.0284 C2ORF34 265 698792 A -3.09 0.0330 C2ORF34 266 698823 G -2.93 0.0318 C2ORF34 267 698827 G -2.72 0.0467 C2ORF34 275 3738980 C -4.91 0.0037 PRKCE 277 6748375 C 2.89 0.0155 FBXO11 281 12620679 C -2.57 0.0379 PSME4 282 805391 T -3.54 0.0029 ACYP2 287 918357 G 2.62 0.0282 ACYP2 288 12615749 G -4.46 0.0165 ACYP2 290 17045754 C -4.22 0.0195 CTNNA2 301 2566539 T -2.94 0.0297 CTNNA2 302 1971766 A -2.75 0.0288 CTNNA2 307 895388 T -4.50 0.0439 CTNNA2 312 6547316 T 2.52 0.0451 DDEF2 316 10204214 T 4.32 0.0174 PLCXD2 320 1513331 C 3.64 0.0362 PLCXD2 323 6784753 C -2.69 0.0308 KALRN 327 16835912 C 3.37 0.0065 CPNE4 330 10934970 C 6.26 0.0438 CPNE4 331 13319291 G 2.57 0.0419 CPNE4 336 9289395 G 3.12 0.0187 RAB6B 340 6765093 G 3.07 0.0112 CLSTN2 356 9836487 G 2.76 0.0251 CLSTN2 358 4683499 G 2.85 0.0256 SLC7A14 372 6788596 G -3.22 0.0130 PLD1 377 7633686 G -4.21 0.0222 HTR3D 385 939334 G 2.63 0.0430 HTR3D 386 6779545 A 3.28 0.0102 IL1RAP 394 6791374 C -5.85 0.0128 RARB 400 17525900 C -4.17 0.0416 STAC 413 17186340 T 4.22 0.0484 ULK4 415 1495698 C 3.37 0.0094 ULK4 417 1691966 G 4.37 0.0003 ULK4 419 13069172 G 4.24 0.0004 ERC2 447 885211 A -2.83 0.0249 FHIT 454 639244 G 3.50 0.0068 FHIT 455 2253211 C 2.64 0.0283 FHIT 456 2121865 T 2.61 0.0359 CADPS 471 13313979 A -2.74 0.0387 CADPS 474 17280557 A -3.33 0.0236 CADPS 475 17280571 T -3.21 0.0187 CADPS 477 11925708 A -2.91 0.0163 MAGI1 482 2371948 A 7.83 0.0451 GBE1 490 7622741 G 3.30 0.0118 GBE1 491 6769230 A 3.27 0.0133 GBE1 492 2307058 T 2.96 0.0259 GBE1 494 7613144 T 2.90 0.0290 GBE1 498 2680245 A -2.44 0.0446 HTR1F 500 1027689 T 5.15 0.0121 ANK2 517 29306 G 3.14 0.0233 ANK2 518 29311 A 4.00 0.0040 INPP4B 528 2667101 G 2.61 0.0376 INPP4B 529 2667108 C 8.45 0.0314 INPP4B 532 336329 G 8.45 0.0314 INPP4B 534 2276942 A 4.56 0.0322 POU4F2 538 1979903 C -5.99 0.0175 FSTL5 543 6825091 A 3.12 0.0229 FSTL5 544 7442468 C 2.85 0.0358 TLL1 557 11942650 G -6.56 0.0244 PALLD 559 17054309 A -3.49 0.0344 PALLD 564 3109206 T -2.74 0.0255 PALLD 565 11930576 C -2.63 0.0380 PALLD 566 4425335 G -2.92 0.0417 ODZ3 572 2675532 C 3.79 0.0030 ENPP6 574 6830766 G -2.79 0.0260 ENPP6 577 4340829 A -2.65 0.0364 ENPP6 578 6815145 A -2.57 0.0486 ENPP6 579 17584049 C -3.47 0.0057 KIAA1239 592 2973226 C -2.48 0.0387 KIAA1239 593 1382979 A -2.88 0.0372 LIMCH1 598 4343753 T 3.30 0.0201 NPFFR2 614 17775309 G -2.83 0.0283 SCARB2 616 17001533 C -3.95 0.0274 SCD5 621 7684732 C -3.76 0.0163 SCD5 622 17006038 C -4.16 0.0121 PDLIM5 632 6812098 C 3.30 0.0380 SLC2A9 643 7671266 T -3.12 0.0334 FBXL17 646 11242664 G 3.29 0.0410 KCNN2 654 1457762 A 2.56 0.0346 HSD17B4 662 246968 A -2.49 0.0354 SNX2 669 12109789 G 2.49 0.0444 SNX2 670 10519715 A 3.11 0.0183 SNX24 672 6888023 T 3.11 0.0180 SNX24 673 246286 T -2.76 0.0328 SNX24 674 246266 C -2.73 0.0345 DNAH5 686 10513155 A 2.82 0.0289 DNAH5 691 13154455 G 3.35 0.0082 ODZ2 704 2337017 C -6.04 0.0004 ODZ2 707 7714651 A -4.53 0.0148 ODZ2 708 1421989 G -5.09 0.0015 ODZ2 711 6868169 G 2.88 0.0246 CDH10 722 3822429 T -3.57 0.0032 SLC45A2 723 35388 T -2.72 0.0199 CMYA5 753 11960229 C 3.66 0.0275 CMYA5 754 6880680 C 5.09 0.0115 CMYA5 755 3828611 G 5.34 0.0158 SEMA5A 770 11134354 A -3.63 0.0162 NKAIN2 794 1832252 G 2.47 0.0424 NKAIN2 796 1031881 C -4.54 0.0044 NKAIN2 797 687667 A -3.12 0.0487 UTRN 817 11155367 A 3.10 0.0467 SYNE1 819 718527 A 2.96 0.0146 ATXN1 841 909786 G -2.89 0.0172 SLC17A4 844 9358890 G 8.10 0.0048 SLC17A1 845 1324082 A -3.20 0.0299 BTN3A1 851 17610161 A -4.15 0.0202 ELOVL5 867 9474507 A 3.73 0.0259 KLHL32 882 1737646 A -4.54 0.0199 CUX1 885 2960266 A 2.63 0.0354 CUX1 886 2694158 T 3.06 0.0170 CADPS2 892 2428769 G -2.82 0.0281 EXOC4 910 6954842 A 2.81 0.0384 DGKI 916 980796 A -2.74 0.0389 CNTNAP2 928 6963627 T 2.45 0.0457 CNTNAP2 931 11972784 C 3.19 0.0238 CNTNAP2 934 10952682 G 3.24 0.0202 CNTNAP2 935 6953679 A 3.57 0.0107 CNTNAP2 936 700320 A 3.89 0.0040 CHN2 958 7781003 T -2.79 0.0332 CRHR2 965 2190242 C 3.49 0.0166 BMPER 979 7806522 C -3.72 0.0046 BMPER 981 12672492 A -2.99 0.0345 CDC2L5 989 9639817 T 2.54 0.0432 CACNA2D1 1037 12531682 T -3.63 0.0071 CACNA2D1 1039 2237524 G -3.87 0.0058 CACNA2D1 1040 7788848 A -3.38 0.0128 PCLO 1054 4129230 T 3.91 0.0028 PCLO 1055 10240976 T 3.07 0.0119 SEMA3E 1057 17287452 T -4.42 0.0227 SEMA3E 1061 1972459 C -2.71 0.0381 SEMA3A 1063 6965990 A 3.20 0.0092 SEMA3A 1064 11976072 T 3.05 0.0127 SEMA3A 1066 7806871 G -3.06 0.0131 SEMA3A 1067 17298417 C -2.88 0.0190 SEMA3A 1069 3801629 G 2.81 0.0237 SEMA3A 1070 727651 G 2.57 0.0378 ADAM22 1076 1688886 G 4.01 0.0012 ADAM22 1077 2282948 C 3.51 0.0055 ADAM22 1078 2282949 C 3.40 0.0066 ADAM22 1083 4140919 G 3.35 0.0471 NXPH1 1086 6962955 A -2.97 0.0163 DYNC1I1 1093 6968143 G 4.08 0.0412 GRHL2 1096 13275653 C -2.71 0.0346 GRHL2 1097 4734037 C -3.86 0.0120 NCALD 1098 1131862 G -3.80 0.0101 NCALD 1101 2226401 C -3.66 0.0125 ZFPM2 1104 1481026 T 3.17 0.0283 FER1L6 1126 4355755 T -2.85 0.0397 FER1L6 1127 7838453 A -3.59 0.0024 FER1L6 1133 7819868 G 3.30 0.0069 COL22A1 1150 4475485 T -4.12 0.0408 CSMD1 1179 4487803 G 3.28 0.0112 CSMD1 1180 17065933 A -2.94 0.0425 CSMD1 1182 7829968 T 3.21 0.0237 CSMD1 1185 7014880 A -2.75 0.0204 SFRP1 1188 4736959 C 2.58 0.0407 SFRP1 1189 11781990 A 2.82 0.0353 MCPH1 1197 1530408 C 3.54 0.0247 MCPH1 1209 2515435 G 2.86 0.0247 KCNB2 1227 13251896 G -2.61 0.0327 KCNB2 1230 2196904 C -2.70 0.0378 KCNB2 1232 13277104 G -2.53 0.0397 MMP16 1236 6994019 T -3.07 0.0256 MMP16 1238 3844198 A -2.99 0.0331 MMP16 1241 4548227 A -3.15 0.0177 GABBR2 1245 1930139 G -3.17 0.0258 ABL1 1273 10901294 T -4.94 0.0394 OLFM1 1278 665748 A 6.28 0.0044 OLFM1 1279 542172 A 6.02 0.0064 KIAA1797 1285 12338810 T -4.00 0.0135 KIAA1797 1286 12336110 A -3.94 0.0163 KIAA1797 1288 16938162 C 3.99 0.0016 KIAA1797 1289 10511687 G 3.87 0.0020 KIAA1797 1294 10511693 G 3.60 0.0094 KIAA1797 1298 7030990 G 3.66 0.0105 KIAA1797 1299 4977881 A 3.38 0.0125 KIAA1797 1300 4468020 T 3.24 0.0162 TEK 1308 2273719 T -3.63 0.0418 PIP5K1B 1317 4745375 T 3.21 0.0184 PCSK5 1329 914367 T -3.25 0.0118 NTRK2 1335 1187321 A 4.47 0.0069 NTRK2 1336 1187328 G 3.46 0.0409 ATE1 1363 7086628 C -2.76 0.0196 ATE1 1364 1219505 T -3.04 0.0093 MYO3A 1380 3781117 C -3.63 0.0401 KCNMA1 1401 7897566 C 4.28 0.0006 ELMOD1 1419 683266 A 2.66 0.0404 MICAL2 1422 10765929 T -2.82 0.0286 ARNTL 1430 7107711 C -3.27 0.0325 SPON1 1440 10832170 T 2.59 0.0336 SPON1 1441 1406356 A 2.70 0.0285 SPON1 1442 7116296 T -2.45 0.0472 INSC 1445 1792571 A 3.42 0.0146 C11ORF49 1453 12796744 T -2.44 0.0483 DLG2 1466 6592202 C -3.34 0.0072 DLG2 1467 4451754 A -3.43 0.0068 DLG2 1469 11234194 C -2.80 0.0278 DLG2 1471 11234222 A -4.38 0.0004 DLG2 1474 6592211 A -3.49 0.0044 DLG2 1475 7101454 C -3.35 0.0067 KCNC2 1503 10735985 G 2.70 0.0349 KCNC2 1504 2471664 C 3.44 0.0209 NAV3 1510 10859620 G -2.87 0.0220 NAV3 1513 1012088 G 3.39 0.0127

NAV3 1515 7295890 C 3.30 0.0152 ITGBL1 1532 4772403 T -2.73 0.0378 ITGBL1 1535 1436261 C -3.57 0.0159 FGF14 1538 7334753 C 2.84 0.0230 FGF14 1539 9518534 T 2.71 0.0305 FGF14 1540 10508075 A 2.49 0.0455 N4BP2L2 1543 206337 A 3.64 0.0169 N4BP2L2 1544 1081796 A 3.26 0.0422 N4BP2L2 1545 169600 A 2.86 0.0471 TRPC4 1562 3812837 C 3.67 0.0069 TRPC4 1563 1538146 T 3.40 0.0102 TRPC4 1564 9594238 C -3.51 0.0315 FNDC3A 1567 2181539 G 3.11 0.0179 FNDC3A 1568 1983805 G 2.86 0.0285 SLAIN1 1573 1343911 A -3.64 0.0227 SLAIN1 1575 9318496 T 3.29 0.0475 SLAIN1 1576 1146920 C 4.21 0.0023 SLAIN1 1577 8000788 T 4.37 0.0206 SLAIN1 1578 10507874 G 4.22 0.0235 GPC5 1585 9556229 G 5.01 0.0107 GPC6 1588 9516222 G 3.28 0.0370 GPC6 1595 9561551 C -3.18 0.0257 NPAS3 1602 6571604 C -5.66 0.0006 NPAS3 1603 6571605 A -4.86 0.0024 SAMD4A 1617 8006657 A 2.82 0.0254 RGS6 1624 36318 G 2.73 0.0291 RGS6 1625 11158926 T 2.49 0.0392 CCDC88C 1642 4904770 T -3.07 0.0493 BCL11B 1650 2614463 T 2.44 0.0429 RYR3 1654 2572175 A -2.54 0.0380 RYR3 1658 11638307 A -2.97 0.0499 C15ORF41 1663 8024344 C -4.39 0.0190 TBC1D2B 1682 2241885 C 2.87 0.0222 TBC1D2B 1684 11634607 T 3.53 0.0061 TBC1D2B 1685 2867985 A 2.67 0.0456 ARNT2 1688 4628923 C -3.39 0.0133 ARNT2 1689 11072931 T -3.48 0.0356 ARNT2 1691 4778615 T -3.63 0.0271 KIFC3 1697 8058401 G -2.74 0.0441 KIFC3 1698 1559404 T -4.24 0.0213 CDH13 1719 11150496 T 2.79 0.0246 CDH13 1722 2059230 T 2.55 0.0461 USP10 1732 8060725 A 3.56 0.0055 CA10 1749 11652641 G -3.48 0.0220 MSI2 1751 8066677 G -3.11 0.0158 SDK2 1754 1846334 A -3.32 0.0086 OSBPL1A 1758 275857 C 7.89 0.0075 CDH7 1781 8092259 G 2.55 0.0466 PTPRM 1798 8089695 C 5.08 0.0245 KIAA0802 1803 12386117 A -4.72 0.0055 MACROD2 1809 6079395 G 2.65 0.0309 PTPRT 1836 6065487 A -2.54 0.0436 KCNB1 1844 6095546 A -2.82 0.0441 CDH4 1847 4812313 G -2.65 0.0485 PLCB4 1859 6077505 C -2.74 0.0322 SLC37A1 1871 401396 C -2.39 0.0418 SLC37A1 1872 381899 A -2.75 0.0456 ARFGAP3 1876 6002963 G -3.00 0.0178 PACSIN2 1882 4140554 C -3.67 0.0027 PACSIN2 1883 7291153 C -3.47 0.0048 PACSIN2 1887 737782 G 3.23 0.0081 PACSIN2 1888 2284097 C -3.35 0.0061 PACSIN2 1889 738379 A -3.24 0.0080 TTLL1 1891 135001 C 2.68 0.0263 TTLL1 1892 135002 C 2.63 0.0298 EFCAB6 1893 137160 G 2.61 0.0333

TABLE-US-00003 TABLE 2 Alleles Influencing PANSS Scales Gene Name Sequence ID NCBI RS # Allele PANSS Scale Beta P NGF 6 6327 A General -1.31 0.03698 NGF 7 7513144 C Positive 1.13 0.02823 CGN 16 1547832 A General -2.33 0.02189 RP1-21O18.1 17 4661563 A Negative -0.90 0.04530 RP1-21O18.1 22 2235787 G General -1.39 0.03026 OLFML2B 25 4657131 A Negative 1.08 0.02441 OLFML2B 26 2499836 T Negative 1.04 0.03150 SEC16B 30 1934650 C Positive 1.26 0.03996 RALGPS2 31 4652319 T General -1.76 0.01175 RALGPS2 32 12076230 G General -1.66 0.01214 USH2A 42 7548730 C Positive 1.08 0.01006 USH2A 43 6665313 A Positive 1.37 0.01278 USH2A 44 12403674 T Positive 1.36 0.01382 USH2A 45 301759 T Negative 0.93 0.02905 USH2A 46 301760 C Negative 0.92 0.03137 USH2A 49 12030122 C Negative 1.59 0.03936 ESRRG 50 6658528 T General -1.49 0.02399 ESRRG 56 2820879 A General -1.68 0.04989 ESRRG 56 2820879 A Negative -1.32 0.02803 RYR2 63 10802596 T General 1.69 0.01523 RYR2 64 16835155 G Negative -1.50 0.02501 RYR2 65 3924864 C General 2.32 0.03225 RYR2 66 2779400 A General -1.76 0.00703 CHRM3 69 16838637 G General 1.27 0.03790 FMN2 76 12145060 A Negative 0.92 0.04972 FMN2 76 12145060 A General 1.57 0.01831 FMN2 77 12021945 C General 1.41 0.03332 FMN2 79 11801848 C General 1.48 0.03579 FMN2 83 1542400 G General -1.27 0.03929 FMN2 83 1542400 G Positive -0.79 0.03629 FMN2 85 11799544 T Positive 1.43 0.04573 FMN2 86 10926257 T General 2.29 0.04767 PLD5 88 924775 A General -1.84 0.02179 AGBL4-C1ORF165 91 319965 A Negative 1.17 0.01131 AGBL4-C1ORF165 97 3121518 A General -1.34 0.03132 SCP2 98 3766762 C General -3.52 0.02101 ELTD1 100 17102632 T Positive 1.23 0.02211 PRKACB 104 2134646 T Positive 0.92 0.01931 HPCAL1 105 16856020 T General 1.87 0.04416 HPCAL1 105 16856020 T Negative 2.04 0.00178 KCNF1 106 4669647 T Negative 1.08 0.04260 NTSR2 108 4669767 C General -1.38 0.03301 NAP5 109 4283469 A Positive -2.24 0.01708 RAB3GAP1 112 16831315 C General 2.96 0.00574 RAB3GAP1 113 935614 G General 2.00 0.04759 ZRANB3 114 16831601 T General 2.57 0.01784 ZRANB3 115 16831751 G General 2.89 0.00863 LRP1B 122 9283437 C Positive 0.97 0.02021 LRP1B 125 12616665 G Positive -1.06 0.02819 LRP1B 127 12990449 C Positive -1.00 0.03679 LRP1B 128 352994 T Positive -0.98 0.03320 KYNU 129 2043944 T Negative 1.52 0.00074 KYNU 130 10176234 A Negative 1.48 0.00110 KYNU 131 351673 T Negative 1.27 0.00346 ARHGAP15 140 10928200 T Positive 0.98 0.01803 ARHGAP15 141 13031917 C Negative 0.93 0.04590 ARHGAP15 141 13031917 C Positive 0.94 0.02134 KIF5C 142 7355478 T Positive 1.36 0.04467 KIF5C 143 4667369 C Positive -0.82 0.04565 FMNL2 145 1370504 C Positive 0.91 0.04383 FMNL2 146 6434113 C Positive 1.03 0.02260 FMNL2 148 3817620 G Negative -1.72 0.02497 KCNJ3 149 2961962 C General -1.77 0.00502 KCNJ3 150 2961957 C General -1.55 0.01804 KCNJ3 151 2937600 G Positive -0.91 0.03136 PKP4 152 6437190 G Negative 1.43 0.01279 PKP4 153 2108217 C Negative 1.39 0.01531 PKP4 154 2051946 T Negative 1.00 0.02982 PKP4 155 1476672 T Negative 1.16 0.04007 PKP4 157 2528635 G Negative 1.02 0.02743 PKP4 158 2528582 G General -1.56 0.01977 PKP4 158 2528582 G Negative -1.12 0.01771 PKP4 159 2711072 C Negative 1.03 0.03103 PLA2R1 161 3828324 C Negative -0.92 0.03300 PLA2R1 162 2667012 C Negative 1.23 0.00572 KCNH7 164 12613181 C Negative -1.42 0.04160 SCN3A 165 11677254 C General -1.86 0.00493 SCN3A 165 11677254 C Negative -1.57 0.00074 SCN1A 166 6731591 C Negative -1.30 0.02573 SCN1A 167 7607543 C Negative -1.13 0.04935 SCN9A 169 7589835 A Negative 1.40 0.04401 SCN9A 169 7589835 A General 2.73 0.00528 SCN9A 170 6725008 C General 2.05 0.02469 SCN9A 171 6746030 A General 2.03 0.02833 SCN9A 172 2226711 C General 1.98 0.03274 PDE1A 187 16823124 A General -1.77 0.00963 PDE1A 188 10497597 T General -1.63 0.01735 PDE1A 190 9332425 T General -1.66 0.01271 ALS2 191 3731702 C Negative -1.13 0.03035 PARD3B 196 1540369 G Positive 0.91 0.04019 PARD3B 199 10490293 T Positive 0.86 0.04547 PARD3B 202 1079943 G General -1.29 0.04578 NRP2 203 955395 T General -1.62 0.01216 NRP2 203 955395 T Negative -1.16 0.01021 NRP2 205 6435306 A General -1.38 0.03253 NRP2 205 6435306 A Negative -0.97 0.02904 PIP5K3 207 10497899 T General -4.21 0.01635 PIP5K3 207 10497899 T Positive -2.73 0.01236 ERBB4 209 12998535 T Negative -1.01 0.04673 CUL3 211 11891006 G Negative -1.31 0.03780 IRS1 212 2396427 G Positive 1.43 0.03569 COL4A4 213 1317770 C Positive -0.95 0.01597 COL4A4 214 4566357 A Positive -0.79 0.04094 SAG 220 2304773 A Negative 2.44 0.00076 SAG 221 894100 A Positive 1.00 0.01983 KLHL29 222 747345 A Positive -1.03 0.01222 KLHL29 223 737565 A Positive -0.98 0.01504 KLHL29 224 747344 G Positive -0.97 0.01602 KLHL29 226 7570872 G Positive -1.00 0.01732 KCNK3 228 7584568 G General -1.35 0.03767 DPYSL5 231 540490 T General 1.33 0.03877 BRE 234 17006590 C Negative -1.18 0.02453 CRIM1 237 6757374 T General 2.27 0.04854 CRIM1 238 3770939 T Negative -1.09 0.02472 CRIM1 239 11885390 A Negative -0.97 0.04757 CRIM1 241 3732073 G Negative -1.09 0.01727 SLC8A1 246 417614 A General 1.56 0.02508 SLC8A1 247 2072531 T Positive -0.87 0.02680 SLC8A1 248 417591 G General 1.54 0.04341 SLC8A1 249 11885401 C General 2.19 0.02219 SLC8A1 250 17026033 G General 1.85 0.02261 SLC8A1 251 17026039 G General 1.76 0.03210 HAAO 252 6738169 G Negative -1.06 0.02751 C2ORF34 257 786616 C Negative -1.36 0.01079 C2ORF34 259 1067343 A Negative -1.33 0.01141 C2ORF34 261 1067378 A General -1.49 0.04429 C2ORF34 261 1067378 A Positive -0.96 0.03708 C2ORF34 264 1067402 T Negative -1.31 0.01452 C2ORF34 265 698792 A Negative -1.28 0.01651 C2ORF34 275 3738980 C General -2.20 0.01320 C2ORF34 275 3738980 C Negative -2.13 0.00060 PRKCE 276 666334 T Negative 1.13 0.02631 PRKCE 277 6748375 C Negative 0.90 0.04040 PRKCE 277 6748375 C General 1.51 0.01573 PSME4 282 805391 T General -1.78 0.00430 PSME4 282 805391 T Negative -1.41 0.00121 PSME4 283 805330 A Negative -1.19 0.00681 PSME4 284 805360 T Negative -1.16 0.01190 PSME4 286 10183655 T Negative -1.15 0.01001 ACYP2 287 918357 G Negative 1.17 0.00787 ACYP2 288 12615749 G Negative -1.55 0.02400 ACYP2 289 12615793 A Negative -1.46 0.03388 ACYP2 290 17045754 C General -2.54 0.00730 CCDC85A 291 4672096 G Positive -1.56 0.02603 CCDC85A 292 1159916 G Negative 1.32 0.00552 CCDC85A 293 214047 C General -2.12 0.02041 AAK1 299 12622388 G General -1.40 0.04950 CTNNA2 300 7597912 T General -1.95 0.00726 CTNNA2 301 2566539 T General -1.87 0.00808 CTNNA2 303 2566542 C General -1.64 0.03645 CTNNA2 304 7571658 C Positive -1.05 0.00824 CTNNA2 306 318362 C Positive 0.85 0.03781 CTNNA2 307 895388 T Positive -1.69 0.02012 CTNNA2 308 7589069 C Negative 1.78 0.00945 CTNNA2 309 1444539 C Negative 1.36 0.04336 CTNNA2 310 1434064 G Negative -0.99 0.03073 CTNNA2 311 216616 G Negative -1.03 0.03792 CTNNA2 312 6547316 T General 1.38 0.03631 C2ORF46 313 7577544 G Positive -1.34 0.04931 DDEF2 316 10204214 T Positive 1.46 0.01377 DDEF2 316 10204214 T General 1.91 0.04488 PLCXD2 320 1513331 C General 2.46 0.00661 PLCXD2 322 6796087 T Positive -1.10 0.00678 PLCXD2 323 6784753 C Positive -1.06 0.00841 PLCXD2 324 12490166 A Positive 0.87 0.03462 KALRN 327 16835912 C Positive 1.05 0.00881 KALRN 327 16835912 C General 1.60 0.01344 CNTN6 328 3772339 T Positive -1.06 0.01236 CNTN6 329 4286413 T Positive -0.87 0.03300 CPNE4 330 10934970 C General 3.49 0.03174 CPNE4 331 13319291 G Positive 0.85 0.03827 CPNE4 333 9289393 T Negative 0.92 0.04938 CPNE4 334 1875619 C Positive 2.47 0.02017 CPNE4 335 1393561 T Positive 2.45 0.02112 CPNE4 336 9289395 G Negative 1.33 0.00639 CPNE4 337 17297521 C General 2.25 0.01856 CPNE4 338 6806898 T General 2.12 0.02401 CNTN6 339 265799 G Positive -0.84 0.02808 RAB6B 340 6765093 G Positive 0.79 0.04449 RAB6B 340 6765093 G Negative 0.91 0.04151 RAB6B 340 6765093 G General 1.37 0.03067 CNTN6 341 265767 A Positive -0.95 0.01664 CNTN6 342 2055738 C Positive -0.96 0.01615 CNTN6 343 3772290 T Positive -0.83 0.03513 EPHB1 345 4955520 A Positive 1.08 0.00739 EPHB1 347 4955522 A Positive 1.08 0.00739 EPHB1 348 185257 T Positive 0.99 0.01383 EPHB1 349 9825380 T Positive 1.09 0.00745 EPHB1 350 4955524 A Positive 1.04 0.01026 EPHB1 351 936323 T Positive 0.97 0.01685 CLSTN2 356 9836487 G General 1.50 0.02082 CLSTN2 358 4683499 G Negative 0.97 0.03915 CLSTN2 358 4683499 G General 1.43 0.03230 CLSTN2 359 6439927 C Negative 1.34 0.00714 SPSB4 363 7651293 T Positive -2.08 0.02000 SLC6A6 365 1156567 C Negative -1.47 0.03132 SERPINI1 369 1492023 A Positive -1.22 0.03118 SERPINI1 370 11928048 T Positive -1.19 0.03397 SLC7A14 371 1861938 T General -1.51 0.02914 SLC7A14 372 6788596 G General -1.46 0.03211 SLC7A14 372 6788596 G Positive -0.89 0.03413 PLD1 377 7633686 G General -1.90 0.04844 PLD1 378 6767600 T Positive -1.32 0.02048 PLD1 379 2178532 A Positive -1.31 0.02693 NLGN1 380 4894645 T Positive 1.58 0.00617 NLGN1 381 12636180 T Positive 0.95 0.04199 HTR3D 385 939334 G Negative 1.14 0.01755 HTR3D 386 6779545 A Negative 1.29 0.00582 HTR3D 386 6779545 A General 1.34 0.04623 IL1RAP 394 6791374 C Negative -2.58 0.00275 CENTB2 396 2050810 A Negative 1.13 0.04537 CENTB2 397 9859822 G Negative -1.11 0.03605 UBXD7 398 3973 T General -1.38 0.04893 RARB 400 17525900 C Negative -1.88 0.01234 CNTN4 405 1420020 G General 2.22 0.04942 CLASP2 410 9853831 T General -1.28 0.04451 CLASP2 411 7641020 G General -1.44 0.02355 STAC 413 17186340 T General 2.69 0.01598 ULK4 415 1495698 C General 1.87 0.00579 ULK4 416 1691964 T General 2.35 0.00019 ULK4 417 1691966 G Negative 1.34 0.00244 ULK4 418 1691998 G Negative 1.22 0.00598 ULK4 419 13069172 G Negative 1.18 0.00788 ULK4 419 13069172 G General 2.34 0.00019 SEMA3F 424 2518796 G Positive 0.84 0.04723 SEMA3F 425 12632110 A Negative -0.95 0.04788 CACNA2D2 426 743757 C Positive -1.10 0.04985 CACNA2D3 427 11130396 T Positive -1.07 0.01458 ERC2 433 1993539 T Negative 1.17 0.04242 ERC2 435 7647972 C Negative -0.98 0.04457 ERC2 438 7619653 C Negative -1.01 0.03263 ERC2 440 17825409 C Negative -1.29 0.00721 ERC2 442 4974200 G Negative -1.26 0.00942 ERC2 443 4974206 G Negative -1.10 0.02160 ERC2 444 13064525 C Negative -1.09 0.02620 ERC2 445 1546060 C Negative -1.51 0.00117 ERC2 446 6805882 C Negative -1.44 0.00174 ERC2 447 885211 A Negative -1.25 0.00744 ERC2 450 9873381 A Negative -1.16 0.01153 ERC2 453 7627759 C Negative -1.06 0.02017 FHIT 454 639244 G Negative 1.46 0.00222 FHIT 454 639244 G General 1.86 0.00613 FHIT 455 2253211 C Negative 1.24 0.00506 FHIT 455 2253211 C General 1.31 0.03719 FHIT 456 2121865 T General 1.45 0.02600

FHIT 457 13320646 A Negative 0.93 0.04266 FHIT 458 7631246 T Negative 0.91 0.04386 PTPRG 459 624755 G Positive 0.86 0.03164 CADPS 467 1355551 T Negative 1.60 0.00679 CADPS 469 9311842 T Negative 1.24 0.01790 CADPS 471 13313979 A General -1.53 0.02767 CADPS 471 13313979 A Negative -1.13 0.02112 CADPS 473 186236 C Negative -1.19 0.01263 CADPS 474 17280557 A General -1.61 0.03648 CADPS 474 17280557 A Negative -1.48 0.00616 CADPS 475 17280571 T Negative -1.46 0.00361 CADPS 476 17357618 C General -1.60 0.02389 CADPS 476 17357618 C Negative -1.30 0.00899 CADPS 477 11925708 A General -1.65 0.00918 PRICKLE2 479 161661 A Negative 1.10 0.01731 MAGI1 482 2371948 A General 4.96 0.01513 MAGI1 483 9845819 C General -1.65 0.01521 MAGI1 484 7612636 C Positive 0.80 0.04761 FAM19A1 485 11707519 G Negative -1.62 0.01054 FOXP1 487 2196356 C Positive 0.94 0.02442 GBE1 490 7622741 G Negative 1.06 0.02757 GBE1 490 7622741 G General 1.75 0.01095 GBE1 491 6769230 A Negative 1.00 0.03881 GBE1 491 6769230 A General 1.75 0.01152 GBE1 492 2307058 T General 1.63 0.01934 GBE1 494 7613144 T General 1.59 0.02238 GBE1 495 17019088 T Positive -0.99 0.04502 GBE1 498 2680245 A General -1.43 0.02444 GBE1 498 2680245 A Negative -0.98 0.02995 GBE1 499 3860595 C Negative 0.96 0.03451 HTR1F 500 1027689 T Positive 1.46 0.02814 HTR1F 500 1027689 T General 2.38 0.02649 DKK2 505 379333 T Positive -1.49 0.03572 COL25A1 508 794149 G Negative 0.97 0.03330 COL25A1 509 3096483 C Negative 0.94 0.04193 COL25A1 510 3096489 C Negative 0.91 0.04566 ANK2 512 13134375 C Negative -1.38 0.00232 ANK2 513 13107082 G Negative 1.37 0.00252 ANK2 514 413019 C Negative 1.34 0.00306 ANK2 517 29306 G Negative 1.14 0.02465 ANK2 518 29311 A Negative 1.37 0.00716 ANK2 518 29311 A General 1.80 0.01303 NDST3 521 2389501 A Positive -1.24 0.04798 MAML3 525 6819304 A General -1.91 0.04975 IL15 527 17007695 C Positive 1.51 0.03432 INPP4B 528 2667101 G Negative 0.96 0.03672 INPP4B 529 2667108 C General 4.31 0.03599 INPP4B 531 1353603 A Negative 3.06 0.00875 INPP4B 532 336329 G Negative 2.97 0.03997 INPP4B 532 336329 G General 4.31 0.03599 INPP4B 533 17015544 T Positive 1.63 0.00671 INPP4B 534 2276942 A Positive 2.11 0.00222 INPP4B 535 3775655 C Positive 1.84 0.00689 INPP4B 536 2627828 G Positive 1.91 0.03133 POU4F2 538 1979903 C Negative -2.17 0.01897 FSTL5 543 6825091 A General 1.85 0.01004 FSTL5 544 7442468 C General 1.79 0.01173 FSTL5 545 1431490 G General 2.68 0.01648 FSTL5 546 12499128 A General 2.60 0.01918 FSTL5 547 17459658 C General 2.01 0.03261 LDB2 552 157631 G General 3.03 0.01049 LDB2 553 284210 T General 2.50 0.04007 LDB2 556 13110882 G Negative -1.30 0.00288 TLL1 557 11942650 G Positive -1.88 0.04937 PALLD 559 17054309 A Negative -1.21 0.04563 PALLD 564 3109206 T Negative -1.20 0.00755 PALLD 565 11930576 C Negative -1.15 0.01329 PALLD 566 4425335 G Negative -1.45 0.00572 PALLD 567 4280700 T Negative -1.46 0.02035 PALLD 568 12511925 T Negative -1.31 0.04313 ODZ3 570 2726792 G Positive 1.01 0.01596 ODZ3 571 2675534 T Negative 1.77 0.00084 ODZ3 572 2675532 C Positive 0.90 0.03089 ODZ3 572 2675532 C Negative 1.38 0.00338 ODZ3 572 2675532 C General 1.51 0.02450 ENPP6 574 6830766 G General -1.36 0.03770 ENPP6 575 4431268 A General -1.55 0.02259 ENPP6 576 4241786 C General -1.53 0.02423 ENPP6 577 4340829 A General -1.46 0.02730 ENPP6 578 6815145 A General -1.47 0.03043 ENPP6 579 17584049 C General -1.85 0.00475 ENPP6 579 17584049 C Positive -1.02 0.01215 KIAA1239 589 4585313 C General 3.06 0.01647 KIAA1239 590 17575883 A Positive -1.10 0.04116 KIAA1239 592 2973226 C Positive -0.95 0.01429 KIAA1239 593 1382979 A Positive -1.04 0.02140 UBE2K 595 2054718 T Positive 1.27 0.01985 UBE2K 596 192779 A Positive 1.28 0.01435 LIMCH1 598 4343753 T General 2.02 0.00656 NPFFR2 611 7654531 T Negative 1.04 0.03353 NPFFR2 612 6824703 C Negative 1.04 0.03375 NPFFR2 614 17775309 G General -1.64 0.01530 SCD5 620 7679857 A Positive -1.24 0.02071 SCD5 621 7684732 C General -1.83 0.02561 SCD5 622 17006038 C Positive -1.24 0.02202 SCD5 622 17006038 C Negative -1.20 0.04882 SCD5 623 6848340 T General -2.27 0.03066 FAM13A1 626 4544678 C General 1.49 0.01797 FAM13A1 627 7691186 G General 1.48 0.01929 PDLIM5 632 6812098 C General 1.68 0.04393 SLC2A9 637 13111638 T Negative -1.40 0.01145 SLC2A9 641 12509955 T Negative -1.34 0.01153 SLC2A9 643 7671266 T Negative -1.45 0.00682 FBXL17 646 11242664 G Negative 1.33 0.02514 FBXL17 646 11242664 G General 1.86 0.02767 PJA2 653 11957188 T Positive -2.79 0.00495 KCNN2 654 1457762 A General 1.34 0.03426 HSD17B4 662 246968 A General -1.60 0.00943 SNX2 669 12109789 G Positive 0.79 0.04779 SNX2 670 10519715 A Negative 0.97 0.04493 SNX2 670 10519715 A General 1.42 0.03964 SNX2 671 2407403 G Negative -1.14 0.01761 SNX24 672 6888023 T General 1.42 0.03843 SNX24 673 246286 T Negative -0.97 0.03999 SNX24 674 246266 C Negative -0.96 0.04460 SNX24 674 246266 C Positive -0.86 0.04092 SNX24 675 6866400 A Negative 0.96 0.04515 VDAC1 677 4958172 A General -1.98 0.03716 TRPC7 680 3777150 A Negative 1.13 0.01239 TRPC7 682 963590 C Positive -0.91 0.03266 DNAH5 686 10513155 A General 1.39 0.03933 DNAH5 688 4701997 T General 2.38 0.00027 DNAH5 691 13154455 G General 2.22 0.00079 GRIA1 694 7735696 C Negative 0.98 0.02728 GRIA1 695 17518831 C Negative 0.90 0.04258 GRIA1 696 778822 C Positive -1.18 0.00987 GRIA1 701 7708391 A General -1.47 0.03123 ODZ2 704 2337017 C General -3.31 0.00022 ODZ2 704 2337017 C Negative -1.45 0.02177 MYO10 705 428263 A Positive 0.92 0.02306 MYO10 706 388887 T Positive 0.87 0.03024 ODZ2 707 7714651 A General -2.07 0.03300 ODZ2 707 7714651 A Positive -1.38 0.02204 ODZ2 708 1421989 G General -2.67 0.00145 ODZ2 708 1421989 G Positive -1.53 0.00320 ODZ2 711 6868169 G Positive 1.19 0.00429 ODZ2 711 6868169 G General 1.55 0.02104 ODZ2 712 11748886 G Positive 1.72 0.04326 MYO10 713 11750538 G Positive -0.88 0.03391 MYO10 714 11133860 G Positive -1.16 0.01532 PLEKHG4B 716 9312845 T Negative 1.69 0.00876 PLEKHG4B 717 9312850 G Negative 1.56 0.01509 PLEKHG4B 718 6888246 T Negative 1.55 0.01701 PLEKHG4B 719 3853521 A Negative 1.57 0.01763 PLEKHG4B 720 6885136 C General 1.37 0.02941 CDH10 722 3822429 T General -1.48 0.02017 CDH10 722 3822429 T Negative -1.07 0.01629 CDH10 722 3822429 T Positive -1.02 0.00950 SLC45A2 723 35388 T Negative -1.00 0.02024 SLC45A2 724 2278008 C Negative -0.98 0.04719 C1QTNF3 725 17583316 C Negative -1.27 0.00913 C1QTNF3 728 9292523 C Negative -1.11 0.01589 EGFLAM 730 4869580 T Negative 1.66 0.01214 AHRR 734 4956936 C Negative 1.01 0.03880 AHRR 735 2672734 C Negative -1.12 0.01572 EXOC3 736 2561667 T Negative -1.05 0.02605 ITGA1 739 1047481 G General -1.35 0.04787 ITGA2 740 3212576 G Negative 1.17 0.04568 CMYA5 753 11960229 C General 2.02 0.01984 CMYA5 754 6880680 C General 2.80 0.00792 CMYA5 755 3828611 G Negative 1.86 0.02235 CMYA5 755 3828611 G General 2.70 0.01945 SEMA5A 768 985723 A Negative 1.48 0.02151 SEMA5A 769 257094 C Negative 1.30 0.04861 SEMA5A 770 11134354 A General -2.05 0.00944 SEMA5A 771 4702625 G General -1.88 0.01741 SEMA5A 772 268481 C General -2.13 0.02437 SEMA5A 773 268529 G General -1.34 0.04990 SLC22A16 775 9398237 T Negative -1.24 0.01156 TRDN 778 2873479 A Negative 1.59 0.03459 TRDN 779 17737379 T Negative -1.54 0.01951 TRDN 780 1367674 T Negative 1.33 0.03747 NKAIN2 793 6910988 T Negative -0.95 0.02895 NKAIN2 794 1832252 G Negative 1.01 0.02390 NKAIN2 795 1871329 C General -2.30 0.00182 NKAIN2 796 1031881 C General -2.58 0.00200 NKAIN2 796 1031881 C Positive -1.11 0.03233 NKAIN2 797 687667 A General -2.04 0.01379 NKAIN2 798 497817 G General -1.77 0.02935 NKAIN2 799 609783 T General -1.76 0.03029 NKAIN2 800 781487 C Positive 1.85 0.00482 PDE7B 810 6570049 T Positive -2.10 0.02725 UTRN 817 11155367 A General 1.73 0.03241 SYNE1 818 2813484 G Negative -0.94 0.04334 SYNE1 819 718527 A General 1.40 0.02741 PARK2 824 9365311 C General -1.45 0.02482 PARK2 826 7750426 G Negative -0.99 0.02186 PARK2 827 9295173 G Negative 0.92 0.03672 PARK2 828 10945823 A Negative 1.08 0.03564 PARK2 829 2846470 A Negative -1.00 0.03486 PDE10A 837 566759 G Negative -1.47 0.02131 ATXN1 839 235147 A Negative -1.11 0.01191 ATXN1 841 909786 G General -1.42 0.02549 SLC17A4 844 9358890 G Positive 2.64 0.00453 SLC17A4 844 9358890 G General 4.20 0.00520 SLC17A1 845 1324082 A Negative -1.16 0.03294 SLC17A3 848 1165158 T Positive -1.03 0.03652 SLC17A2 849 442601 C General -1.56 0.02006 BTN3A1 851 17610161 A General -2.16 0.02111 LRFN2 861 9369205 A Negative 1.30 0.00591 LRFN2 863 403319 A Negative -0.93 0.04704 PPP2R5D 864 3823423 A Positive 1.57 0.03282 KLC4 865 4714658 A Positive 2.32 0.01682 ELOVL5 867 9474507 A General 1.85 0.03489 RIMS1 869 530028 G Positive -1.11 0.00434 RIMS1 870 511211 C Positive -1.10 0.00527 RIMS1 875 2463749 C Positive -0.85 0.03747 RIMS1 877 1015945 G Positive -0.92 0.02887 KLHL32 882 1737646 A General -2.34 0.02228 CUX1 884 940482 T Negative -1.52 0.01147 CUX1 885 2960266 A Positive 0.94 0.02025 CUX1 886 2694158 T Positive 1.04 0.01248 CUX1 886 2694158 T General 1.46 0.02952 CADPS2 887 2471212 G Positive 1.20 0.01064 CADPS2 888 1476898 T Positive 0.99 0.04874 CADPS2 889 2471194 A Positive 0.99 0.04663 CADPS2 892 2428769 G General -1.41 0.03591 CADPS2 892 2428769 G Negative -0.95 0.04415 EXOC4 910 6954842 A Negative 1.08 0.03039 DGKI 915 16874961 C Positive -1.14 0.00805 DGKI 916 980796 A Positive -1.07 0.01273 CREB3L2 917 273981 C Positive 1.07 0.00707 CREB3L2 918 273988 A Positive 1.06 0.00696 CREB3L2 919 273992 C Positive -0.95 0.02157 TBXAS1 923 41723 G Negative 1.51 0.01523 ETV1 924 9639168 C General 1.52 0.02832 CNTNAP2 926 1639481 G Positive 0.86 0.02913 CNTNAP2 929 1639484 T Positive 0.82 0.03752 CNTNAP2 931 11972784 C General 1.61 0.02929 CNTNAP2 932 4726861 A Positive 0.98 0.03148 CNTNAP2 933 2022226 C Positive 1.00 0.01451 CNTNAP2 934 10952682 G Positive 1.08 0.01747 CNTNAP2 934 10952682 G General 1.64 0.02495 CNTNAP2 935 6953679 A Positive 1.27 0.00514 CNTNAP2 935 6953679 A General 1.76 0.01632 CNTNAP2 936 700320 A Positive 1.25 0.00455 CNTNAP2 936 700320 A General 1.77 0.01287 CNTNAP2 937 1404731 C General -2.25 0.04818 PTPRN2 943 10265417 T Positive -0.80 0.04787 STK31 944 12532929 T General 1.71 0.03979 CHN2 958 7781003 T General -1.41 0.03974 CHN2 958 7781003 T Positive -0.88 0.03774 CHN2 959 3750103 C General 2.93 0.02045 CHN2 960 10951234 C Positive -1.04 0.04125 ZNRF2 964 42603 G Negative 2.11 0.04303 CRHR2 965 2190242 C Positive 0.97 0.03961 CRHR2 965 2190242 C Negative 1.14 0.03332 CRHR2 966 4723003 T General 2.30 0.03182 FLJ22374 968 7781249 A General 1.31 0.03675 FLJ22374 971 10258097 A General -1.43 0.02758 BMPER 976 6975236 T Negative 1.09 0.02086

BMPER 979 7806522 C General -1.86 0.00672 BMPER 979 7806522 C Negative -1.02 0.03492 BMPER 979 7806522 C Positive -0.84 0.04938 VPS41 983 17768153 A Negative 1.25 0.04993 CDC2L5 987 10272641 G Negative 0.89 0.04734 CDC2L5 989 9639817 T Negative 1.11 0.01672 CDC2L5 990 17171658 T Negative 0.97 0.03259 SDK1 991 11766511 G Positive 0.77 0.04561 ABCA13 1001 3923511 G Positive -0.92 0.04200 GRB10 1003 2244347 C Negative 1.11 0.02401 GRB10 1004 6976501 G General -1.65 0.04393 WBSCR17 1006 757841 C General 1.31 0.03691 WBSCR17 1008 2190223 C General 1.32 0.03726 LIMK1 1011 2855726 A Negative 1.01 0.03860 LIMK1 1012 444606 G Negative 0.99 0.04151 LIMK1 1013 398608 T Negative 1.01 0.04762 GTF2IRD1 1014 2267834 G Positive 1.07 0.01631 MAGI2 1020 10238177 A Positive -0.94 0.03100 MAGI2 1026 6954793 C Negative 1.65 0.01244 MAGI2 1027 10280554 T Negative 1.59 0.01300 MAGI2 1028 7778707 G Negative 1.55 0.02511 MAGI2 1031 4730829 C Negative 1.31 0.01825 CACNA2D1 1033 258728 A Negative -1.26 0.01477 CACNA2D1 1034 2059037 C Negative -1.70 0.00734 CACNA2D1 1036 7781562 A Positive -1.07 0.01486 CACNA2D1 1037 12531682 T General -1.54 0.02929 CACNA2D1 1037 12531682 T Negative -1.06 0.03247 CACNA2D1 1038 978326 C General -1.58 0.02696 CACNA2D1 1038 978326 C Negative -1.11 0.02788 CACNA2D1 1039 2237524 G General -1.60 0.02896 CACNA2D1 1039 2237524 G Positive -1.16 0.01094 CACNA2D1 1039 2237524 G Negative -1.12 0.03117 CACNA2D1 1040 7788848 A General -1.44 0.04357 CACNA2D1 1040 7788848 A Negative -1.01 0.04418 CACNA2D1 1040 7788848 A Positive -0.93 0.03516 PCLO 1046 2888019 T Positive 0.77 0.04641 PCLO 1049 12539066 T Positive -1.33 0.00307 PCLO 1052 17157177 T General -1.45 0.02225 PCLO 1053 16887406 G General -1.25 0.04624 PCLO 1054 4129230 T Positive 0.90 0.03415 PCLO 1054 4129230 T General 1.88 0.00620 PCLO 1055 10240976 T Negative 1.24 0.00568 PCLO 1055 10240976 T General 1.36 0.03362 SEMA3E 1056 2722963 G General 1.34 0.04670 SEMA3E 1057 17287452 T Negative -1.62 0.02340 SEMA3E 1060 3801562 C General 1.41 0.02882 SEMA3E 1061 1972459 C General -1.50 0.02815 SEMA3A 1062 2535786 A Negative -1.15 0.03083 SEMA3A 1063 6965990 A Positive 0.86 0.03141 SEMA3A 1063 6965990 A Negative 1.10 0.01479 SEMA3A 1064 11976072 T Negative 1.08 0.01598 SEMA3A 1065 13228082 G Negative 1.06 0.01895 SEMA3A 1066 7806871 G Negative -1.03 0.02271 SEMA3A 1066 7806871 G Positive -0.86 0.03166 SEMA3A 1067 17298417 C Negative -1.00 0.02690 SEMA3A 1067 17298417 C Positive -0.79 0.04662 SEMA3A 1068 10488268 T Negative 0.96 0.03467 SEMA3A 1069 3801629 G Negative 0.95 0.03703 ABCB4 1072 2097937 G Negative -1.18 0.04542 ABCB4 1073 31662 A General -2.27 0.02439 ABCB4 1074 31671 G Positive 0.98 0.04998 ADAM22 1076 1688886 G Positive 1.41 0.00059 ADAM22 1076 1688886 G General 1.73 0.00790 ADAM22 1077 2282948 C General 1.50 0.02362 ADAM22 1078 2282949 C Positive 1.38 0.00067 ADAM22 1078 2282949 C General 1.42 0.02975 ADAM22 1079 6951172 T Positive 1.06 0.01095 ADAM22 1080 9632709 C Positive 1.09 0.00887 ADAM22 1081 2299199 G Positive 1.03 0.01243 ADAM22 1083 4140919 G Positive 1.09 0.04647 ADAM22 1083 4140919 G General 1.85 0.03572 ADAM22 1084 2299205 T Positive 1.38 0.04625 NXPH1 1086 6962955 A General -1.65 0.01131 PON1 1090 2057681 G General -1.36 0.04956 PON1 1091 705378 T General 1.38 0.03793 DYNC1I1 1093 6968143 G General 2.57 0.01413 GRHL2 1096 13275653 C General -1.56 0.02002 GRHL2 1096 13275653 C Negative -1.02 0.03158 GRHL2 1097 4734037 C General -2.00 0.01321 NCALD 1098 1131862 G General -2.12 0.00599 NCALD 1098 1131862 G Negative -1.15 0.03461 NCALD 1099 16868201 A General -2.08 0.01430 NCALD 1099 16868201 A Negative -1.17 0.04984 NCALD 1101 2226401 C General -1.87 0.01488 ZFPM2 1102 16873003 C General 2.06 0.00671 ZFPM2 1103 6992053 A General 2.01 0.00736 ZFPM2 1104 1481026 T General 1.95 0.00957 ZFPM2 1105 302957 C General 1.29 0.04556 ZFPM2 1107 7003141 C Positive 1.04 0.01769 ZFPM2 1108 1025856 C Positive 0.83 0.03562 ZFPM2 1110 2958710 G Positive 0.81 0.04240 CSMD3 1111 6981814 A Positive -1.16 0.01347 CSMD3 1112 10505174 A Positive -1.01 0.03301 CSMD3 1113 10216803 T Positive -0.99 0.03494 CSMD3 1114 16883753 T Positive -0.97 0.03940 CSMD3 1118 4354335 G Negative 1.04 0.03539 SAMD12 1119 4629902 A Positive 0.86 0.03641 SAMD12 1123 1607924 G Negative 0.95 0.04672 FBXO32 1125 6990407 G Positive -1.07 0.04614 FER1L6 1127 7838453 A General -1.65 0.00776 FER1L6 1127 7838453 A Positive -1.09 0.00467 FER1L6 1127 7838453 A Negative -0.86 0.04907 FER1L6 1133 7819868 G Positive 1.05 0.00814 FER1L6 1133 7819868 G General 1.49 0.02014 FER1L6 1134 4521739 G Positive 0.99 0.01293 FER1L6 1135 11784115 A Positive 0.94 0.01813 FER1L6 1136 10103694 T Negative -1.18 0.02336 DLC1 1139 2203838 C Negative -1.51 0.01065 ADCY8 1142 7464362 G General 1.35 0.03729 ADCY8 1143 11781997 A General 1.58 0.01106 ADCY8 1144 7459573 G General 1.43 0.02701 KCNQ3 1146 6471066 G General 1.71 0.04615 COL22A1 1150 4475485 T General -2.77 0.00847 COL22A1 1151 7838450 C Positive -0.80 0.04576 COL22A1 1152 13279213 A Negative 1.12 0.02925 SGCZ 1154 11990657 T General 1.52 0.03744 SGCZ 1156 4427170 T General 1.51 0.01977 SLC7A2 1159 2720574 C General -1.89 0.04017 ENTPD4 1173 17089263 G Positive 1.47 0.04339 CSMD1 1179 4487803 G General 1.72 0.01061 CSMD1 1182 7829968 T General 1.67 0.02433 CSMD1 1185 7014880 A General -1.60 0.00997 UNC5D 1186 2589344 T Negative -1.56 0.00589 SFRP1 1188 4736959 C Positive 1.07 0.00917 SFRP1 1190 11779707 C Positive 0.99 0.01758 SFRP1 1191 7833518 T Positive 0.82 0.04424 SFRP1 1192 968427 G Negative -0.88 0.04825 MCPH1 1197 1530408 C General 2.01 0.01503 MCPH1 1202 2920660 A General 1.83 0.03201 MCPH1 1203 2916741 G General 1.74 0.04297 NKAIN3 1207 17245081 A General 1.39 0.03183 MCPH1 1208 3020213 T Positive 0.90 0.03313 MCPH1 1209 2515435 G General 1.33 0.04676 DEPDC2 1216 7006061 T Positive 1.30 0.03870 DEPDC2 1219 6990381 T Negative 0.94 0.03520 KCNB2 1227 13251896 G Negative -1.10 0.01395 KCNB2 1227 13251896 G Positive -0.82 0.03948 KCNB2 1230 2196904 C Negative -1.11 0.01975 KCNB2 1231 1866740 A Negative -0.93 0.04845 KCNB2 1232 13277104 G Negative -1.02 0.02351 KCNB2 1232 13277104 G Positive -0.89 0.02549 MMP16 1236 6994019 T General -1.78 0.01335 MMP16 1236 6994019 T Negative -1.07 0.03595 MMP16 1237 1879203 C Negative -1.10 0.03726 MMP16 1238 3844198 A General -1.70 0.02028 MMP16 1241 4548227 A Negative -1.40 0.00384 GABBR2 1242 1435253 T General -1.91 0.01876 GABBR2 1243 10985765 C General -1.86 0.01922 GABBR2 1244 2778913 T General -2.14 0.03218 GABBR2 1245 1930139 G Negative -1.24 0.01820 STOM 1260 17086 G Positive -0.79 0.04711 FREQ 1269 12003792 A Positive 0.88 0.04157 ABL1 1273 10901294 T General -3.10 0.01311 TSC1 1275 11243940 G Positive -1.03 0.02027 TSC1 1276 7035308 A Positive -0.90 0.04546 OLFM1 1278 665748 A Positive 1.49 0.03800 OLFM1 1278 665748 A General 3.50 0.00246 OLFM1 1279 542172 A General 3.19 0.00573 INPP5E 1280 3812591 C Negative 1.28 0.01173 KIAA1797 1285 12338810 T General -2.65 0.00175 KIAA1797 1285 12338810 T Positive -1.17 0.02646 KIAA1797 1286 12336110 A General -2.65 0.00204 KIAA1797 1286 12336110 A Positive -1.12 0.03654 KIAA1797 1289 10511687 G Negative 1.52 0.00099 KIAA1797 1289 10511687 G General 2.10 0.00138 KIAA1797 1291 2383162 G General -1.37 0.04082 KIAA1797 1292 4977823 T General -1.54 0.02497 KIAA1797 1294 10511693 G Negative 1.24 0.01526 KIAA1797 1295 4579612 C General 2.05 0.00322 KIAA1797 1296 4977848 A General -1.44 0.03549 KIAA1797 1298 7030990 G Negative 1.22 0.02058 KIAA1797 1299 4977881 A Negative 1.10 0.02813 KIAA1797 1299 4977881 A General 1.93 0.00666 KIAA1797 1300 4468020 T Negative 1.03 0.03784 KIAA1797 1300 4468020 T General 1.89 0.00718 TEK 1306 10967731 A Positive -1.11 0.00607 TEK 1307 1322051 A Positive -1.89 0.04390 TEK 1308 2273719 T General -2.13 0.02223 TEK 1309 12339867 C General -2.01 0.02410 PIP5K1B 1312 7023009 T Positive 0.81 0.03533 PIP5K1B 1313 12686355 A Positive -0.96 0.01543 PIP5K1B 1316 11144133 T Negative 1.07 0.01861 PIP5K1B 1317 4745375 T Negative 1.24 0.01342 APBA1 1318 10481751 T Negative 1.24 0.01613 APBA1 1318 10481751 T General 1.52 0.03800 TRPM3 1319 1932701 C Negative -1.89 0.00415 TRPM3 1322 1337028 T Negative -0.93 0.04526 TRPM3 1323 2993010 A Negative -1.07 0.02022 PCSK5 1327 7862766 T General 2.16 0.02270 PCSK5 1329 914367 T General -1.37 0.04347 PCSK5 1329 914367 T Negative -1.26 0.00808 NTRK2 1335 1187321 A Negative 1.39 0.02333 NTRK2 1335 1187321 A General 2.22 0.01051 NTRK2 1336 1187328 G Negative 1.31 0.03538 NTRK2 1337 1899641 G General 1.60 0.02849 DAPK1 1338 1927976 G Negative -1.00 0.02631 SORCS3 1341 10884026 G Positive -1.01 0.04628 SORCS3 1345 2496022 A General -1.28 0.04790 CUGBP2 1353 3243 C General 1.45 0.04284 VTI1A 1355 10885352 T Positive -0.91 0.03509 VTI1A 1357 7907012 G Negative 1.07 0.02739 VTI1A 1360 4145776 G Negative 0.99 0.04223 ATE1 1363 7086628 C Positive -1.09 0.00447 ATE1 1364 1219505 T Positive -1.29 0.00067 ATE1 1364 1219505 T General -1.21 0.04798 ATE1 1365 1693682 A General -1.29 0.04510 ATE1 1366 10732824 A General -2.18 0.04567 ATE1 1367 2420970 T Positive 1.23 0.00122 ATE1 1368 11200251 T Positive 0.89 0.03135 ATE1 1369 11200260 T General 1.82 0.04378 CTBP2 1370 4962718 C Positive -0.96 0.02804 ARMC3 1371 17440393 A Positive 1.18 0.01570 ARMC3 1372 11013210 T Positive 1.11 0.02029 PITRM1 1383 3740607 A Positive -0.82 0.03317 PITRM1 1384 4242746 T Positive -0.85 0.04967 SLC16A9 1386 6481469 A General 2.59 0.03613 SLC16A9 1387 3763747 C Negative -1.48 0.00519 SLC16A9 1388 2242206 T Negative -1.30 0.00719 SLC16A9 1389 1171648 A Negative -1.34 0.00846 SLC16A9 1390 1171643 G Negative -1.33 0.01007 PRKCQ 1392 9423765 A Negative 0.96 0.03963 KCNMA1 1401 7897566 C Positive 1.04 0.01086 KCNMA1 1401 7897566 C General 1.60 0.01494 KCNMA1 1401 7897566 C Negative 1.64 0.00034 NRG3 1408 11193681 T Positive -1.24 0.02809 NRG3 1410 474496 G General 1.42 0.03465 NRG3 1411 512064 A General 1.25 0.04994 GALNTL4 1421 7122801 T General -1.49 0.03276 MICAL2 1422 10765929 T Positive -1.21 0.00386 MICAL2 1423 2010463 A Positive -0.80 0.04857 MICAL2 1424 11822285 T Positive -0.84 0.03138 OPCML 1428 10894536 A Negative 1.68 0.03902 ARNTL 1430 7107711 C General -1.86 0.01999 ARNTL 1431 7112233 T General -1.70 0.03204 OPCML 1432 7107264 C General -1.89 0.04851 SPON1 1435 1507527 C General 1.48 0.03603 SPON1 1436 2049723 C General 1.59 0.02683 SPON1 1437 1528668 C Negative 1.03 0.02759 SPON1 1440 10832170 T Negative 1.20 0.00721 SPON1 1440 10832170 T General 1.31 0.04048 SPON1 1441 1406356 A Negative 1.20 0.00803 SPON1 1441 1406356 A General 1.40 0.03069 SPON1 1442 7116296 T General -1.33 0.04002 SPON1 1442 7116296 T Negative -1.03 0.02319 SPON1 1443 11023088 T Negative -0.98 0.03476 INSC 1445 1792571 A Negative 1.62 0.00168 INSC 1445 1792571 A General 1.63 0.02657 KCNA4 1446 11030913 C Positive 1.25 0.01607 KCNA4 1447 10835607 A Positive 1.08 0.03341 STIM1 1448 7952083 C Positive -0.85 0.02340 STIM1 1449 10835249 G Positive -0.80 0.04205

STIM1 1451 2959068 T Positive -0.84 0.04313 TRIM21 1452 1426378 A Positive -1.17 0.02572 DLG2 1455 11233564 A Positive -2.74 0.00227 DLG2 1456 11233565 C Positive -2.49 0.00550 DLG2 1457 6592113 A Negative -0.99 0.03066 DLG2 1458 2507850 A Negative -0.97 0.04316 DLG2 1459 7108874 T Negative -1.22 0.02033 DLG2 1462 2514147 G Negative 1.58 0.03268 DLG2 1463 10898192 G Negative 1.66 0.02050 DLG2 1465 1945832 T Positive -1.58 0.02446 DLG2 1466 6592202 C General -1.35 0.03773 DLG2 1466 6592202 C Positive -1.04 0.00980 DLG2 1466 6592202 C Negative -0.94 0.03982 DLG2 1467 4451754 A General -1.40 0.03522 DLG2 1467 4451754 A Positive -1.07 0.00927 DLG2 1468 1943708 C Positive -0.89 0.02995 DLG2 1469 11234194 C Positive -0.88 0.03398 DLG2 1470 11234221 A Positive -1.13 0.00457 DLG2 1471 11234222 A General -1.86 0.00385 DLG2 1471 11234222 A Negative -1.45 0.00134 DLG2 1472 4943900 C Negative 1.00 0.02898 DLG2 1474 6592211 A General -1.49 0.02007 DLG2 1474 6592211 A Positive -1.14 0.00424 DLG2 1475 7101454 C General -1.42 0.02852 DLG2 1475 7101454 C Positive -1.08 0.00720 DLG2 1476 582652 A Negative -1.34 0.04170 ATXN2 1480 1544396 G Negative 1.09 0.04327 ITPR2 1490 1049376 G General -1.44 0.04725 TMEM16B 1491 9645764 C Negative -1.14 0.02799 TMEM16B 1499 11612136 A Positive 1.25 0.01255 KCNC2 1502 10879888 G Negative 1.74 0.00069 KCNC2 1503 10735985 G Negative 1.53 0.00116 KCNC2 1504 2471664 C Negative 2.13 0.00009 NAV3 1508 1677923 G Negative 1.57 0.04286 NAV3 1510 10859620 G General -1.72 0.00858 NAV3 1512 11107419 T General -1.46 0.03758 NAV3 1514 1677893 A Positive 0.79 0.04382 NAV3 1515 7295890 C General 1.80 0.01110 NAV3 1516 998070 T General -1.24 0.04974 NALCN 1524 7337100 G General 1.38 0.04041 NALCN 1529 9557622 G General -1.43 0.02253 ITGBL1 1530 1335594 A General -1.55 0.02549 ITGBL1 1532 4772403 T General -1.58 0.02099 ITGBL1 1532 4772403 T Positive -0.93 0.02766 ITGBL1 1533 7338172 G General -1.53 0.04581 ITGBL1 1535 1436261 C General -2.13 0.00591 ITGBL1 1536 9518494 T General -1.28 0.04145 FGF14 1537 7319796 A Negative -1.02 0.02862 FGF14 1538 7334753 C Positive 0.90 0.02586 FGF14 1539 9518534 T Positive 0.88 0.02965 MTIF3 1542 7334690 A Negative 1.11 0.03028 N4BP2L2 1543 206337 A General 1.98 0.01322 N4BP2L2 1545 169600 A General 1.67 0.02673 N4BP2L2 1546 208431 G General 1.52 0.04552 TRPC4 1553 9576332 G General 1.79 0.00793 TRPC4 1554 7336008 A General 1.56 0.01718 TRPC4 1555 7338239 G General 1.45 0.02776 TRPC4 1557 4943529 C General 1.39 0.03093 TRPC4 1558 1577007 C Positive -0.89 0.02610 TRPC4 1559 1556541 C Positive -0.89 0.03077 TRPC4 1560 1924378 A General -1.28 0.04723 TRPC4 1562 3812837 C Positive 1.40 0.00147 TRPC4 1562 3812837 C General 1.62 0.02264 TRPC4 1563 1538146 T Positive 1.34 0.00176 TRPC4 1564 9594238 C General -1.83 0.03205 TRPC4 1564 9594238 C Positive -1.23 0.02001 FNDC3A 1567 2181539 G General 1.87 0.00633 FNDC3A 1568 1983805 G General 1.57 0.02200 SLAIN1 1573 1343911 A General -2.17 0.00964 SLAIN1 1574 1279445 G Positive 1.50 0.02077 SLAIN1 1575 9318496 T General 1.71 0.04936 SLAIN1 1576 1146920 C Positive 1.09 0.01523 SLAIN1 1576 1146920 C Negative 1.16 0.02302 SLAIN1 1576 1146920 C General 1.97 0.00651 SLAIN1 1577 8000788 T General 2.62 0.00773 SLAIN1 1578 10507874 G General 2.52 0.00977 GPC5 1579 7992120 T General 1.86 0.03400 GPC5 1584 913005 T General -1.58 0.01369 GPC5 1585 9556229 G Negative 1.77 0.01409 GPC5 1585 9556229 G General 2.24 0.02954 GPC5 1586 6492630 A Negative -0.92 0.04368 GPC5 1587 2148226 G Negative 1.04 0.02066 GPC6 1588 9516222 G Positive 1.04 0.04055 GPC6 1593 9524193 T Negative 1.08 0.03752 GPC6 1594 10492635 C General -1.74 0.03755 GPC6 1595 9561551 C Positive -0.99 0.03328 NPAS3 1597 8022434 T Negative 1.56 0.04940 NPAS3 1599 243291 G Negative -0.88 0.04978 NPAS3 1601 10133530 A General 1.84 0.02280 NPAS3 1602 6571604 C General -3.41 0.00007 NPAS3 1602 6571604 C Positive -1.59 0.00300 NPAS3 1603 6571605 A General -2.95 0.00042 NPAS3 1603 6571605 A Positive -1.35 0.00913 GNG2 1615 10873056 G Negative -2.70 0.01947 SAMD4A 1617 8006657 A General 1.94 0.00326 SAMD4A 1619 8021151 G General 1.77 0.00588 PPP2R5E 1620 10137202 C General 2.11 0.02322 PPP2R5E 1621 972984 C Negative -1.55 0.00440 PPP2R5E 1622 1255741 A Negative -1.18 0.01323 RGS6 1624 36318 G General 1.69 0.00984 RGS6 1625 11158926 T Positive 0.79 0.04420 RGS6 1625 11158926 T General 1.45 0.02171 RGS6 1629 847241 A Negative -1.19 0.00792 RGS6 1631 2283380 T General 1.34 0.04679 KCNK10 1632 12587003 C General 1.82 0.00754 KCNK10 1633 12185033 T Positive -0.83 0.04727 RPS6KA5 1634 1152423 C Negative 1.00 0.03427 RPS6KA5 1635 941847 T Positive 0.90 0.04654 RPS6KA5 1636 1286148 C Negative 1.38 0.01088 RPS6KA5 1637 7156252 T Positive 1.07 0.01018 RPS6KA5 1639 1075014 C Positive 1.07 0.01208 RPS6KA5 1641 7492628 G Positive 1.20 0.00460 CCDC88C 1642 4904770 T Positive -1.48 0.00338 CCDC88C 1644 10131741 G Positive -1.20 0.00746 CCDC88C 1646 8007791 A Positive -1.20 0.00785 CCDC88C 1647 11160004 C General 1.67 0.03585 BCL11B 1648 807450 C Negative 0.98 0.04426 BCL11B 1650 2614463 T Positive 0.83 0.03335 ATP10A 1651 12442216 T Negative -0.91 0.04698 RYR3 1654 2572175 A General -1.40 0.02906 RYR3 1654 2572175 A Positive -0.95 0.01583 RYR3 1656 1390159 T General 3.29 0.03110 RYR3 1657 1495284 C General 3.08 0.03459 RYR3 1658 11638307 A Negative -1.26 0.02375 C15ORF41 1661 12443190 G Negative 1.11 0.01131 C15ORF41 1663 8024344 C General -2.87 0.00336 C15ORF41 1663 8024344 C Negative -1.79 0.00919 C15ORF41 1664 4923723 C General -2.06 0.01990 GLDN 1670 2445781 G General 1.53 0.03501 GLDN 1671 17648128 A Positive 1.14 0.00603 GLDN 1672 17648140 G Positive 1.08 0.00897 RORA 1679 12914584 G General -1.51 0.03438 TBC1D2B 1682 2241885 C Negative 0.98 0.03548 TBC1D2B 1682 2241885 C General 1.35 0.04053 TBC1D2B 1683 8030999 G Positive 1.38 0.01666 TBC1D2B 1684 11634607 T Negative 1.18 0.01249 TBC1D2B 1684 11634607 T General 1.63 0.01540 ARNT2 1688 4628923 C Negative -1.17 0.01854 ARNT2 1688 4628923 C Positive -1.06 0.01677 ARNT2 1689 11072931 T Positive -1.10 0.04031 ARNT2 1691 4778615 T Negative -1.19 0.04811 ARNT2 1691 4778615 T Positive -1.13 0.03351 SH3GL3 1692 10520577 T Positive 1.28 0.00472 TMC5 1694 1985395 C Negative 0.96 0.04800 TMC5 1694 1985395 C General 1.66 0.01583 EEF2K 1696 10521118 A Positive 1.95 0.01256 KIFC3 1698 1559404 T Negative -1.53 0.02447 A2BP1 1701 1155959 C General 1.47 0.02311 WWOX 1708 8061908 C Positive -0.84 0.03862 WWOX 1711 11641213 G Positive 0.80 0.04062 MPHOSPH6 1714 7405231 C Positive 0.89 0.01797 CDH13 1719 11150496 T General 1.43 0.02777 CDH13 1722 2059230 T Positive 0.82 0.04825 CDH13 1730 889491 T Positive 0.85 0.04749 USP10 1732 8060725 A Positive 0.82 0.04831 USP10 1732 8060725 A Negative 1.32 0.00519 USP10 1732 8060725 A General 1.42 0.03482 CRISPLD2 1733 2641697 C Positive 1.21 0.00331 CRISPLD2 1734 2641698 T Positive 1.14 0.00651 CRISPLD2 1735 16974822 G Positive -1.40 0.00247 CRISPLD2 1736 774205 G Positive 0.84 0.04168 CRISPLD2 1738 982994 T Positive 0.85 0.04298 CRISPLD2 1739 2646107 C Positive -1.07 0.01544 DNAH9 1741 16945383 G Positive 0.80 0.03533 DNAH9 1742 1468501 C Positive -1.04 0.02836 CA10 1749 11652641 G General -1.95 0.01410 CA10 1749 11652641 G Positive -1.08 0.02873 MSI2 1751 8066677 G General -2.14 0.00148 MSI2 1752 8067335 A Positive -0.83 0.04425 SDK2 1754 1846334 A Positive -1.22 0.00294 OSBPL1A 1758 275857 C Positive 2.65 0.00557 OSBPL1A 1758 275857 C General 3.17 0.04077 OSBPL1A 1759 641885 T General -2.46 0.03775 CHST9 1760 17703962 G Positive 1.38 0.01471 CHST9 1762 9965371 C Positive 1.21 0.02735 DLGAP1 1763 9635857 G Positive 0.94 0.04321 NEDD4L 1766 7243662 G Positive 1.24 0.01038 NEDD4L 1767 1008899 A Positive 1.18 0.01254 NEDD4L 1768 4941364 G Positive 1.14 0.01420 NEDD4L 1769 292444 C Positive 0.93 0.02791 NEDD4L 1770 525839 A Positive 0.90 0.03453 NEDD4L 1771 11663936 T Negative -1.18 0.03859 NEDD4L 1772 17064977 C Negative 1.10 0.03738 NEDD4L 1773 11152073 A Negative 1.07 0.04122 CDH7 1781 8092259 G Negative 1.38 0.00316 CDH7 1781 8092259 G General 1.41 0.03486 CDH7 1782 7228669 T General 1.34 0.04448 CDH7 1783 1942832 A Negative 1.26 0.00745 CDH7 1784 1942831 G General 1.34 0.04464 CDH7 1786 1484725 T Negative 1.24 0.00820 CDH7 1790 1564815 C Negative 2.42 0.02279 DOK6 1791 12961718 C General 1.58 0.02195 DOK6 1792 8097743 G Positive -0.85 0.02753 DOK6 1793 4426448 G Positive 0.94 0.01905 DOK6 1794 12605879 G Positive 0.90 0.02201 MBP 1796 11660442 A Negative 1.07 0.02397 PTPRM 1797 495288 G Negative 2.51 0.02561 PTPRM 1798 8089695 C Negative 2.27 0.00638 KIAA0802 1803 12386117 A General -2.31 0.00964 KIAA0802 1803 12386117 A Positive -1.32 0.01762 KIAA0802 1804 7235093 A Negative 2.20 0.00394 LDLR 1805 8110695 A General 1.72 0.02348 LDLR 1807 1433099 A Positive -0.88 0.04421 MACROD2 1809 6079395 G Positive 0.84 0.03441 MACROD2 1809 6079395 G Negative 0.99 0.02883 MACROD2 1810 6079910 C General -2.02 0.04025 KIF16B 1813 6043875 C General -1.62 0.01173 KIF16B 1818 6135739 G General -1.34 0.04077 KIF16B 1821 6034464 A General -1.40 0.02717 KIF16B 1823 12624938 A General 1.83 0.03290 KIF16B 1826 6075069 T General 2.46 0.00261 KIF16B 1827 6080359 C Negative -1.16 0.02720 PTPRT 1832 6065432 T Negative -1.35 0.00638 PTPRT 1833 746413 C Negative -1.04 0.02087 PTPRT 1833 746413 C Positive 1.15 0.00399 PTPRT 1834 6065434 T Negative -1.27 0.00885 PTPRT 1835 6016688 T Positive 0.98 0.03708 PTPRT 1836 6065487 A Positive -1.00 0.01421 PTPRT 1838 2017914 G General 1.40 0.04442 PTPRT 1839 6072869 G Negative 1.24 0.01854 KCNB1 1841 1961192 T Negative -0.95 0.03860 KCNB1 1844 6095546 A General -1.48 0.04378 KCNB1 1844 6095546 A Positive -0.93 0.04204 KCNB1 1845 4647 T Positive -0.95 0.03795 CDH4 1846 6028127 G General -1.41 0.04280 CDH4 1847 4812313 G General -1.42 0.04339 FERMT1 1855 8121939 G General -1.34 0.04231 PLCB1 1856 6055577 A Positive 1.06 0.04019 PLCB1 1857 2235212 A Positive 0.95 0.04340 PLCB4 1859 6077505 C Negative -1.17 0.01308 PLCB4 1860 6039424 G Negative -0.92 0.04737 C21ORF37 1861 12483129 C Negative 0.97 0.02832 SLC37A1 1872 381899 A Negative -1.39 0.00591 SGSM1 1874 5760752 C Negative 0.97 0.04133 ARFGAP3 1876 6002963 G General -1.76 0.00781 ARFGAP3 1877 738536 A General 1.37 0.02863 PACSIN2 1882 4140554 C General -2.05 0.00135 PACSIN2 1883 7291153 C General -1.95 0.00238 PACSIN2 1887 737782 G Negative 1.16 0.01019 PACSIN2 1887 737782 G General 1.70 0.00803 PACSIN2 1888 2284097 C General -1.87 0.00345 PACSIN2 1889 738379 A General -1.71 0.00737 PACSIN2 1889 738379 A Negative -0.96 0.03380 TTLL1 1891 135001 C Negative 0.99 0.02599 TTLL1 1891 135001 C General 1.26 0.04582 TTLL1 1892 135002 C Negative 0.96 0.03155 TTLL1 1892 135002 C General 1.25 0.04902 EFCAB6 1893 137160 G Positive 0.97 0.01465 EFCAB6 1893 137160 G General 1.35 0.03556

TABLE-US-00004 TABLE 3 Alleles Influencing Individual PANSS Items Gene Sequence ID NCBI RS # Allele PANSS Item Beta P KIF1B 1 3748577 G G15 0.24 0.0074930 KIF1B 2 2297881 C N4 0.90 0.0098590 KIF1B 3 1555849 G N1 0.33 0.0023450 KIF1B 3 1555849 G G15 0.24 0.0082990 KIF1B 4 3748578 A N1 0.35 0.0016060 SYT6 5 611514 A G2 0.23 0.0088800 SYT6 5 611514 A P4 0.20 0.0070350 NGF 6 6327 A N1 -0.30 0.0021770 SLC22A15 8 2488433 T P7 -0.40 0.0060930 SLC22A15 9 7547928 T G8 -0.17 0.0031870 SLC22A15 10 2051060 C G8 -0.16 0.0047370 SLC22A15 11 17035177 T N1 0.56 0.0084980 PTGFRN 12 943371 C G4 -0.77 0.0029300 PTGFRN 13 12078461 A G7 0.65 0.0051320 PTGFRN 14 4641299 G P5 -0.27 0.0057720 PTGFRN 15 3829881 A G1 -0.28 0.0025710 RP1-21O18.1 18 10803343 G G14 0.95 0.0002941 RP1-21O18.1 19 1000313 G G14 0.27 0.0003008 RP1-21O18.1 20 4501834 C G14 0.22 0.0031970 RP1-21O18.1 21 2221926 T G14 0.28 0.0034020 RP1-21O18.1 21 2221926 T G13 0.32 0.0056050 ATF6 23 10918029 A G11 0.41 0.0033720 ATF6 24 7552420 C N1 0.51 0.0021620 OLFML2B 26 2499836 T N4 0.30 0.0026610 OLFML2B 27 12025136 C G16 0.32 0.0020010 OLFML2B 27 12025136 C N6 0.29 0.0071570 FAM78B 28 6662013 T G5 0.21 0.0039550 FAM78B 29 10800181 G G11 -0.22 0.0086260 RALGPS2 31 4652319 T N7 -0.25 0.0043700 RALGPS2 31 4652319 T G15 -0.25 0.0065890 RALGPS2 32 12076230 G G12 -0.26 0.0085520 KCNK2 33 10864143 A N5 0.29 0.0068860 KCNK2 34 2363557 A G10 -0.18 0.0078510 KCNK2 35 2363567 T G10 -0.18 0.0085910 KCNK2 36 6684084 G N5 0.27 0.0087360 KCNK2 37 10779651 C N6 0.36 0.0001705 KCNK2 37 10779651 C N5 0.27 0.0089470 KCNK2 38 1112101 G N6 0.36 0.0005514 KCNK2 39 11120527 T G5 0.22 0.0049310 USH2A 40 2211125 T N6 0.32 0.0023270 USH2A 41 1339411 T N6 0.29 0.0077170 USH2A 42 7548730 C N7 0.22 0.0094820 USH2A 43 6665313 A P3 0.46 0.0025330 USH2A 44 12403674 T P3 0.44 0.0041770 USH2A 47 386654 T G11 0.26 0.0035990 USH2A 48 680410 G G11 0.25 0.0051510 USH2A 49 12030122 C N5 0.47 0.0072360 ESRRG 50 6658528 T G5 -0.23 0.0010100 ESRRG 51 6604635 A G5 -0.21 0.0022990 ESRRG 51 6604635 A G10 -0.16 0.0089390 ESRRG 52 10218694 A P7 0.17 0.0069140 ESRRG 53 12088947 A P7 0.18 0.0074210 ESRRG 54 1498276 G G14 0.21 0.0016130 ESRRG 55 17670802 G G7 0.24 0.0022500 EPHB2 57 10799762 C G14 0.32 0.0029190 EPHB2 58 309473 T N4 -0.28 0.0030420 SLC35F3 59 10495346 T P7 0.28 0.0061170 RYR2 60 1806641 C N3 0.25 0.0028740 RYR2 61 637520 T G11 -0.22 0.0048860 RYR2 62 2275287 A G14 0.19 0.0067060 RYR2 63 10802596 T G13 0.22 0.0100000 RYR2 63 10802596 T G14 0.20 0.0034720 RYR2 65 3924864 C G13 0.37 0.0057310 RYR2 65 3924864 C G14 0.29 0.0071300 RYR2 66 2779400 A G3 -0.29 0.0043720 RYR2 66 2779400 A G13 -0.21 0.0086620 RYR2 67 12141182 T G5 -0.20 0.0091040 RYR2 68 2819743 T G5 -0.23 0.0042810 CHRM3 69 16838637 G G5 0.20 0.0017450 CHRM3 70 1867264 T G5 0.21 0.0019340 CHRM3 70 1867264 T G7 0.25 0.0010800 CHRM3 71 10802795 C G7 0.25 0.0013130 CHRM3 72 6663632 A G7 0.22 0.0030570 CHRM3 73 6657343 A G7 -0.20 0.0082860 CHRM3 74 10802801 A G7 0.22 0.0042560 CHRM3 75 479933 A G3 -0.34 0.0058350 FMN2 76 12145060 A G4 0.22 0.0084360 FMN2 76 12145060 A G2 0.27 0.0039240 FMN2 77 12021945 C G2 0.25 0.0070300 FMN2 78 9970045 A G6 0.30 0.0096920 FMN2 80 7520065 G P4 0.21 0.0060730 FMN2 81 897662 T P4 0.21 0.0045960 FMN2 82 10926188 G P4 0.21 0.0051100 FMN2 84 16832176 C G16 -0.27 0.0094940 FMN2 85 11799544 T G13 0.38 0.0072610 FMN2 86 10926257 T G13 0.37 0.0087780 RGS7 87 12038803 A G11 -0.25 0.0055160 RGS7 87 12038803 A N1 -0.33 0.0025720 CLIC4 89 6604978 C G2 -0.30 0.0016950 CLIC4 90 9332415 T G2 -0.29 0.0022220 AGBL4-C1ORF165 91 319965 A N3 0.24 0.0061090 AGBL4-C1ORF165 91 319965 A N7 0.22 0.0068310 AGBL4-C1ORF165 92 1934395 G G3 -0.28 0.0094430 AGBL4-C1ORF165 93 4285747 C G6 -0.28 0.0038460 AGBL4-C1ORF165 94 12023014 C G6 -0.27 0.0053990 AGBL4-C1ORF165 95 12043418 T G6 -0.27 0.0062110 AGBL4-C1ORF165 96 3121273 G G7 -0.20 0.0088860 SCP2 98 3766762 C G15 -0.53 0.0080520 SCP2 98 3766762 C G11 -0.55 0.0046630 LRP8 99 1288523 A P6 0.28 0.0061260 ELTD1 101 4650634 A G9 -0.32 0.0088300 PRKACB 102 3915908 T P2 -0.28 0.0031410 PRKACB 103 3903924 G P2 0.27 0.0056920 HPCAL1 105 16856020 T N3 0.40 0.0013070 HPCAL1 105 16856020 T N5 0.42 0.0044340 KCNF1 107 4669651 T G6 0.40 0.0006391 NAP5 109 4283469 A P7 -0.41 0.0062590 NAP5 109 4283469 A P4 -0.49 0.0066410 NAP5 110 1434231 C G14 0.19 0.0081370 RAB3GAP1 111 10174944 T G6 0.38 0.0067730 NXPH2 116 17651262 A G6 0.30 0.0020160 LRP1B 117 1486963 C G6 -0.40 0.0001314 LRP1B 118 13021003 C G6 -0.33 0.0008647 LRP1B 119 10469593 C G6 -0.32 0.0011370 LRP1B 120 12479163 A G6 -0.45 0.0000142 LRP1B 120 12479163 A P6 -0.31 0.0031180 LRP1B 121 2171107 A G13 0.22 0.0075710 LRP1B 122 9283437 C P1 0.31 0.0061220 LRP1B 123 4954907 T G6 0.28 0.0082880 LRP1B 124 11681928 A N4 -0.26 0.0089250 LRP1B 125 12616665 G P6 -0.40 0.0007633 LRP1B 126 10496897 A N7 0.24 0.0063040 LRP1B 127 12990449 C P6 -0.38 0.0012510 KYNU 129 2043944 T N2 0.31 0.0003813 KYNU 129 2043944 T N4 0.37 0.0001105 KYNU 129 2043944 T G12 0.27 0.0038560 KYNU 129 2043944 T N3 0.27 0.0012600 KYNU 130 10176234 A G13 0.22 0.0045350 KYNU 130 10176234 A G12 0.26 0.0062530 KYNU 130 10176234 A N2 0.29 0.0008502 KYNU 130 10176234 A N3 0.26 0.0022680 KYNU 131 351673 T N2 0.21 0.0095860 KYNU 131 351673 T N4 0.34 0.0002347 KYNU 132 6429997 C N4 0.28 0.0035140 KYNU 133 6732786 G G6 -0.38 0.0018490 ARHGAP15 134 1869009 A N6 0.27 0.0069890 ARHGAP15 135 11895997 A N1 -0.29 0.0031330 ARHGAP15 136 17814502 A P2 0.40 0.0003225 ARHGAP15 137 10048784 T G3 -0.29 0.0084780 ARHGAP15 138 13011344 G G16 -0.29 0.0082560 ARHGAP15 139 3795872 T G16 -0.29 0.0082980 ARHGAP15 141 13031917 C P3 0.30 0.0079410 FMNL2 147 1561267 C P7 -0.27 0.0097290 PKP4 156 2007493 G G5 -0.20 0.0056870 PKP4 158 2528582 G N7 -0.24 0.0036000 PKP4 158 2528582 G G5 -0.20 0.0057130 PKP4 158 2528582 G P2 -0.25 0.0081930 PLA2R1 160 949753 G P2 -0.31 0.0071790 PLA2R1 161 3828324 C N1 -0.25 0.0083020 PLA2R1 161 3828324 C N6 -0.27 0.0023180 PLA2R1 162 2667012 C N6 0.26 0.0054070 PLA2R1 162 2667012 C N1 0.27 0.0049360 PLA2R1 163 4665145 T G11 0.25 0.0095000 PLA2R1 163 4665145 T G3 0.34 0.0030390 SCN3A 165 11677254 C G7 -0.24 0.0025100 SCN3A 165 11677254 C N4 -0.28 0.0041850 SCN3A 165 11677254 C N1 -0.28 0.0070540 SCN3A 165 11677254 C N2 -0.29 0.0009855 SCN1A 166 6731591 C G7 -0.28 0.0056940 SCN1A 168 497594 G G7 0.25 0.0045790 SCN9A 169 7589835 A G5 0.28 0.0082980 SCN9A 169 7589835 A N1 0.41 0.0084640 SCN9A 169 7589835 A G7 0.35 0.0039360 SCN9A 173 4447616 C P2 0.26 0.0067540 SCN9A 174 6732627 A G4 -0.25 0.0025060 SCN7A 175 5024296 T G13 0.22 0.0078780 SCN7A 175 5024296 T G4 -0.24 0.0055560 CERKL 176 4018756 A N5 0.27 0.0088890 PDE1A 177 13400054 C N4 -0.41 0.0005951 PDE1A 178 3769794 C N3 0.32 0.0022070 PDE1A 179 3769789 G N3 0.29 0.0088030 PDE1A 180 2623438 G N4 -0.40 0.0009703 PDE1A 180 2623438 G N2 -0.32 0.0032780 PDE1A 181 4666828 A N4 -0.38 0.0016920 PDE1A 181 4666828 A N2 -0.29 0.0082390 PDE1A 182 6726543 G G1 0.26 0.0067830 PDE1A 183 833142 A G1 -0.26 0.0043210 PDE1A 183 833142 A G8 -0.15 0.0089830 PDE1A 183 833142 A P1 -0.31 0.0047960 PDE1A 184 833119 C G4 0.29 0.0009323 PDE1A 185 12988258 A G4 0.26 0.0040120 PDE1A 186 6736414 T G1 0.27 0.0083740 PDE1A 187 16823124 A G6 -0.29 0.0047680 PDE1A 188 10497597 T G6 -0.28 0.0059250 PDE1A 189 2887202 A G1 -0.25 0.0072430 PDE1A 189 2887202 A P1 -0.33 0.0039330 PDE1A 190 9332425 T G3 -0.32 0.0016990 PDE1A 190 9332425 T P6 -0.27 0.0085150 PDE1A 190 9332425 T G6 -0.28 0.0047890 ALS2 192 2302610 G G10 -0.26 0.0023280 PARD3B 193 1477179 T G14 0.21 0.0092930 PARD3B 194 2098462 C G14 0.20 0.0074160 PARD3B 195 2878473 C G4 -0.34 0.0010800 PARD3B 196 1540369 G G5 0.23 0.0027160 PARD3B 196 1540369 G G12 0.28 0.0077080 PARD3B 197 2704638 G G5 0.30 0.0017260 PARD3B 198 3845806 A G5 0.20 0.0065550 PARD3B 198 3845806 A P5 0.30 0.0017910 PARD3B 199 10490293 T G12 0.26 0.0095200 PARD3B 200 1606237 T P5 0.28 0.0026520 PARD3B 201 698906 T P5 0.37 0.0033850 NRP2 203 955395 T G13 -0.25 0.0012450 NRP2 203 955395 T N1 -0.29 0.0036830 NRP2 203 955395 T N2 -0.27 0.0018830 NRP2 204 13396083 C G13 -0.21 0.0066730 NRP2 205 6435306 A N1 -0.27 0.0057680 PIP5K3 206 7586020 C G5 -0.20 0.0049350 PIP5K3 207 10497899 T P1 -0.88 0.0035790 PIP5K3 207 10497899 T P6 -0.76 0.0059020 ERBB4 208 11901831 C G10 0.27 0.0075730 ERBB4 210 1992029 G G11 -0.26 0.0065430 COL4A3 215 2178631 C G12 -0.31 0.0010500 COL4A3 215 2178631 C P5 -0.24 0.0061530 DNER 216 6733289 G G10 -0.16 0.0063000 DNER 217 12611671 C G14 0.20 0.0040080 ECEL1 218 12616972 C P5 0.29 0.0016390 CHRNG 219 1201451 T G15 -0.25 0.0060940 SAG 220 2304773 A P7 0.28 0.0070970 SAG 220 2304773 A N4 0.45 0.0030830 SAG 220 2304773 A N6 0.47 0.0020440 KLHL29 222 747345 A N4 -0.29 0.0025940 KLHL29 222 747345 A G16 -0.27 0.0048360 KLHL29 222 747345 A P5 -0.25 0.0062440 KLHL29 225 6727901 G N4 -0.30 0.0017570 KLHL29 225 6727901 G G16 -0.25 0.0086370 KCNK3 228 7584568 G G13 -0.21 0.0081610 KCNK3 229 1627854 G G13 -0.21 0.0090110 DPYSL5 230 486582 C G10 0.17 0.0048990 DPYSL5 232 3769138 G G10 0.17 0.0050320 BRE 233 10189434 T G6 0.31 0.0046780 BRE 235 10189899 A G1 -0.27 0.0030600 BRE 236 1546029 C G10 0.18 0.0068080 CRIM1 237 6757374 T P7 -0.33 0.0043140 CRIM1 237 6757374 T G10 0.29 0.0061260 CRIM1 240 888074 G N6 -0.25 0.0071850 CRIM1 242 2160367 C N6 -0.26 0.0061580 CRIM1 243 848556 T P1 -0.31 0.0039740 CRIM1 244 848532 C G1 -0.31 0.0013040 CRIM1 245 848531 A G1 -0.28 0.0038690 SLC8A1 247 2072531 T P6 -0.29 0.0028790 SLC8A1 247 2072531 T P1 -0.29 0.0079460 SLC8A1 248 417591 G N5 0.31 0.0096150 HAAO 252 6738169 G N1 -0.29 0.0060670 PLEKHH2 253 17414362 A G10 -0.24 0.0007199 PLEKHH2 253 17414362 A G11 -0.25 0.0074160

PLEKHH2 254 2288710 C G14 0.35 0.0070470 PLEKHH2 254 2288710 C G11 0.53 0.0010930 PLEKHH2 254 2288710 C N5 0.52 0.0099950 PLEKHH2 254 2288710 C N7 0.52 0.0012830 PLEKHH2 255 7570252 A G10 -0.18 0.0043850 PLEKHH2 256 10165660 C G10 -0.17 0.0061410 C2ORF34 257 786616 C N7 -0.31 0.0011430 C2ORF34 257 786616 C P2 -0.31 0.0047180 C2ORF34 257 786616 C G15 -0.28 0.0038400 C2ORF34 258 786626 C G9 -0.28 0.0042620 C2ORF34 259 1067343 A P2 -0.29 0.0062780 C2ORF34 260 1584885 C G9 -0.26 0.0023430 C2ORF34 262 1067367 A G9 -0.27 0.0059360 C2ORF34 263 1065786 T G9 -0.28 0.0048720 C2ORF34 265 698792 A G15 -0.28 0.0049980 C2ORF34 265 698792 A N7 -0.27 0.0038670 C2ORF34 268 2341457 A G9 -0.24 0.0058060 C2ORF34 269 1377906 G G15 -0.22 0.0083300 C2ORF34 270 7567272 A P2 -0.25 0.0057880 C2ORF34 271 4953105 G G9 -0.23 0.0077590 C2ORF34 272 10445928 C G9 -0.23 0.0090270 C2ORF34 273 4953122 G P2 -0.24 0.0091370 C2ORF34 274 7603180 C N7 0.29 0.0047560 C2ORF34 275 3738980 C N2 -0.37 0.0020550 C2ORF34 275 3738980 C G7 -0.40 0.0002342 C2ORF34 275 3738980 C N4 -0.37 0.0046210 C2ORF34 275 3738980 C N7 -0.30 0.0063550 C2ORF34 275 3738980 C G16 -0.40 0.0017670 C2ORF34 275 3738980 C N5 -0.47 0.0008419 PRKCE 276 666334 T G10 0.18 0.0080830 PRKCE 277 6748375 C N3 0.27 0.0010920 PRKCE 278 1020445 C G1 -0.27 0.0042010 EPAS1 279 4953340 C N4 -0.28 0.0027890 FBXO11 280 12463595 T G10 0.19 0.0030790 FBXO11 281 12620679 C G13 -0.21 0.0075070 PSME4 282 805391 T G7 -0.24 0.0015200 PSME4 282 805391 T N6 -0.25 0.0054780 PSME4 282 805391 T N1 -0.26 0.0068310 PSME4 282 805391 T G13 -0.23 0.0020840 PSME4 282 805391 T G15 -0.27 0.0008523 PSME4 282 805391 T N7 -0.25 0.0012910 PSME4 283 805330 A N7 -0.22 0.0047520 PSME4 284 805360 T G10 -0.17 0.0059760 PSME4 284 805360 T N7 -0.21 0.0092440 PSME4 285 3731967 A G7 -0.20 0.0099430 PSME4 286 10183655 T N6 -0.25 0.0074630 ACYP2 290 17045754 C G1 -0.37 0.0050170 CCDC85A 291 4672096 G P2 -0.42 0.0097740 CCDC85A 292 1159916 G N5 0.28 0.0090120 CCDC85A 294 2111470 C G4 0.25 0.0045680 CCDC85A 295 1030091 C G14 0.40 0.0099130 OTX1 296 11125946 A N7 0.23 0.0074160 AAK1 297 9789387 A G9 -0.25 0.0048970 AAK1 298 12471316 G N5 0.25 0.0095590 AAK1 299 12622388 G G9 -0.27 0.0064650 CTNNA2 300 7597912 T N7 -0.24 0.0090330 CTNNA2 301 2566539 T G15 -0.24 0.0077290 CTNNA2 305 1319241 A P3 -0.48 0.0040350 CTNNA2 307 895388 T P3 -0.60 0.0030370 CTNNA2 308 7589069 C N1 0.47 0.0019290 CTNNA2 308 7589069 C N5 0.45 0.0037440 CTNNA2 308 7589069 C G7 0.38 0.0016780 CTNNA2 309 1444539 C G7 0.31 0.0074740 CTNNA2 310 1434064 G G7 -0.22 0.0058730 C2ORF46 313 7577544 G P4 -0.46 0.0003160 C2ORF46 314 3111414 C G8 0.19 0.0091600 C2ORF46 314 3111414 C G15 0.33 0.0013790 C2ORF46 315 2914424 T G15 0.36 0.0041090 DDEF2 316 10204214 T G15 0.38 0.0022250 INPP4A 317 17031905 G G14 0.20 0.0076740 INPP4A 318 2278214 A P7 0.20 0.0057790 ATP2B2 319 241508 A P1 0.30 0.0068740 PLCXD2 320 1513331 C G15 0.32 0.0063110 PLCXD2 321 6788543 C P1 -0.30 0.0074850 PLCXD2 322 6796087 T P1 -0.30 0.0075950 PLCXD2 323 6784753 C G15 -0.23 0.0056890 PLCXD2 323 6784753 C P1 -0.29 0.0085480 PLCXD2 323 6784753 C P2 -0.27 0.0032880 PLCXD2 324 12490166 A P3 0.34 0.0033240 CDGAP 325 6438523 A P6 0.27 0.0091720 STXBP5L 326 17249426 A G6 -0.34 0.0064750 KALRN 327 16835912 C G11 0.23 0.0050790 CNTN6 328 3772339 T P1 -0.32 0.0053750 CNTN6 329 4286413 T N1 0.31 0.0018330 CPNE4 332 9812534 C N5 -0.29 0.0051580 CPNE4 336 9289395 G G13 0.22 0.0086320 CPNE4 336 9289395 G N4 0.27 0.0089350 CPNE4 336 9289395 G N2 0.27 0.0032240 CPNE4 336 9289395 G N5 0.29 0.0089530 CPNE4 337 17297521 C G13 0.37 0.0016770 CPNE4 337 17297521 C N6 0.40 0.0047080 CPNE4 338 6806898 T N6 0.37 0.0070530 CPNE4 338 6806898 T G13 0.35 0.0021460 RAB6B 340 6765093 G N2 0.23 0.0064270 RAB6B 340 6765093 G P6 0.27 0.0053900 EPHB1 344 36172 C P2 0.25 0.0056950 EPHB1 346 7644369 T P2 0.28 0.0028780 EPHB1 347 4955522 A P2 0.26 0.0054500 EPHB1 348 185257 T P5 0.26 0.0033630 EPHB1 349 9825380 T P5 0.28 0.0022360 EPHB1 350 4955524 A P2 0.26 0.0057940 EPHB1 351 936323 T P2 0.25 0.0073630 EPHB1 351 936323 T P5 0.27 0.0025230 EPHB1 352 1870196 T G8 0.18 0.0049260 CNTN6 353 1479530 G G11 -0.23 0.0059820 CNTN6 354 2291100 C N3 -0.23 0.0074750 CLSTN2 355 13086670 G G15 0.24 0.0047240 CLSTN2 356 9836487 G G15 0.23 0.0061830 CLSTN2 356 9836487 G N5 0.27 0.0085550 CLSTN2 357 7632885 G N3 0.24 0.0069350 CLSTN2 358 4683499 G G15 0.23 0.0066830 CLSTN2 359 6439927 C G7 0.23 0.0085600 CLSTN2 359 6439927 C N3 0.25 0.0072760 CLSTN2 360 4683509 G G2 -0.32 0.0018500 CLSTN2 361 347975 G P6 -0.31 0.0030380 CLSTN2 361 347975 G G2 -0.27 0.0042070 CLSTN2 362 347973 A G2 -0.25 0.0091370 CLSTN2 362 347973 A P6 -0.28 0.0077160 SPSB4 364 7620622 A G7 0.30 0.0014580 SLC6A6 365 1156567 C P5 0.37 0.0055120 SLC6A6 365 1156567 C N1 -0.41 0.0063420 DAZL 366 4685357 T G8 0.20 0.0015550 DAZL 367 6787063 G P3 -0.30 0.0078670 DAZL 368 13064112 G P3 0.32 0.0098920 PLD1 373 181715 T G8 -0.15 0.0078600 PLD1 374 2290480 A P6 0.31 0.0098860 PLD1 374 2290480 A G6 0.31 0.0080730 PLD1 375 16856569 G G6 0.31 0.0092840 PLD1 375 16856569 G P6 0.31 0.0099570 PLD1 376 4446237 T P6 0.29 0.0040360 NLGN1 381 12636180 T P1 0.33 0.0097910 NLGN1 382 10936780 G G13 -0.41 0.0042770 NLGN1 383 12634066 A G13 -0.39 0.0061200 NLGN1 384 7614469 C P7 -0.21 0.0091360 HTR3D 385 939334 G N3 0.27 0.0025300 HTR3D 385 939334 G G13 0.25 0.0024460 HTR3D 386 6779545 A N6 0.28 0.0041680 HTR3D 386 6779545 A G13 0.27 0.0009273 HTR3D 386 6779545 A N3 0.29 0.0010920 HTR3D 386 6779545 A G15 0.23 0.0083220 HTR3E 387 11718245 A P5 -0.32 0.0044630 LEPREL1 388 1719615 T G6 0.32 0.0083790 LEPREL1 389 1666486 A G6 0.32 0.0083790 LEPREL1 390 1526031 C P4 -0.33 0.0004817 LEPREL1 391 1522930 G P4 -0.28 0.0039020 LEPREL1 392 2667709 G P4 -0.22 0.0098150 IL1RAP 393 2885545 G N2 -0.50 0.0025450 IL1RAP 394 6791374 C N7 -0.46 0.0032290 IL1RAP 394 6791374 C N2 -0.44 0.0081860 IL1RAP 394 6791374 C N4 -0.58 0.0013920 LRRC15 395 6799698 A G8 -0.21 0.0075670 UBXD7 398 3973 T G15 -0.25 0.0060970 CNTN4 399 6785626 A P4 0.20 0.0097310 RARB 400 17525900 C G13 -0.38 0.0041060 RARB 400 17525900 C N3 -0.40 0.0049540 RARB 401 1286738 T P7 0.26 0.0012390 RARB 402 17526942 T G5 -0.29 0.0098670 RARB 403 1656463 A P7 0.28 0.0012580 CNTN4 404 12494838 G N2 0.26 0.0060730 CNTN4 405 1420020 G N7 0.39 0.0062210 CNTN4 406 163352 G G12 -0.34 0.0057050 CLASP2 407 4679039 C P4 -0.22 0.0035350 CLASP2 408 6772776 T P4 -0.21 0.0064810 CLASP2 409 9862261 G P4 -0.19 0.0096500 CLASP2 411 7641020 G P4 -0.20 0.0084190 ARPP-21 412 2305234 A G11 0.38 0.0045210 STAC 413 17186340 T G13 0.35 0.0100000 STAC 413 17186340 T P7 0.34 0.0024810 STAC 413 17186340 T P4 0.45 0.0005653 ULK4 414 7618902 G P5 0.26 0.0064860 ULK4 415 1495698 C G15 0.25 0.0039090 ULK4 415 1495698 C G13 0.24 0.0032920 ULK4 416 1691964 T N7 0.25 0.0015390 ULK4 417 1691966 G N7 0.24 0.0023360 ULK4 418 1691998 G N7 0.23 0.0032560 ULK4 418 1691998 G G10 0.16 0.0069320 ULK4 418 1691998 G G8 0.15 0.0081990 ULK4 419 13069172 G N7 0.22 0.0053180 ULK4 419 13069172 G G15 0.23 0.0039650 ULK4 419 13069172 G G13 0.22 0.0039610 ULK4 420 2272007 A G11 0.31 0.0064130 ITPR1 421 9880562 T N6 0.26 0.0064910 ITPR1 422 7432768 G G12 -0.24 0.0092850 ITPR1 422 7432768 G G6 0.32 0.0007960 SEMA3F 423 2624837 T P3 -0.51 0.0045480 SEMA3F 425 12632110 A N5 -0.32 0.0031660 CACNA2D3 427 11130396 T P7 -0.19 0.0075930 CACNA2D3 428 4928040 A N5 -0.30 0.0094690 ERC2 429 815453 G G15 -0.26 0.0063400 ERC2 430 2132237 C N4 0.29 0.0028920 ERC2 431 11130482 C G15 -0.31 0.0029250 ERC2 432 2168818 T G14 0.23 0.0076590 ERC2 434 9810436 A N5 0.39 0.0013900 ERC2 434 9810436 A P1 -0.35 0.0075910 ERC2 436 4974168 C N5 0.38 0.0025340 ERC2 437 1485672 T N5 -0.34 0.0015390 ERC2 439 1869156 G N5 -0.29 0.0046120 ERC2 441 4974134 A N5 -0.30 0.0061560 ERC2 442 4974200 G N5 -0.29 0.0073480 ERC2 445 1546060 C N1 -0.30 0.0031360 ERC2 445 1546060 C N6 -0.30 0.0015960 ERC2 446 6805882 C N6 -0.30 0.0020990 ERC2 446 6805882 C N2 -0.27 0.0020750 ERC2 447 885211 A G5 -0.19 0.0064520 ERC2 448 9814545 A N1 -0.31 0.0052050 ERC2 449 1878270 C G7 -0.22 0.0046770 ERC2 450 9873381 A N1 -0.29 0.0046080 ERC2 450 9873381 A G7 -0.26 0.0014620 ERC2 450 9873381 A N2 -0.23 0.0089980 ERC2 451 9881216 T G7 -0.21 0.0068840 ERC2 451 9881216 T N1 -0.30 0.0027270 ERC2 452 7633140 A G7 -0.21 0.0072940 ERC2 453 7627759 C N1 -0.30 0.0032360 ERC2 453 7627759 C G7 -0.21 0.0075200 FHIT 454 639244 G G5 0.20 0.0050940 FHIT 454 639244 G N4 0.29 0.0039900 FHIT 454 639244 G G7 0.24 0.0035580 FHIT 454 639244 G G16 0.26 0.0072680 FHIT 454 639244 G N2 0.23 0.0098560 FHIT 454 639244 G N6 0.32 0.0014180 FHIT 455 2253211 C N3 0.22 0.0081450 PTPRG 459 624755 G P1 0.29 0.0074050 PTPRG 459 624755 G G9 0.24 0.0084740 PTPRG 460 3821880 A N5 -0.27 0.0086610 PTPRG 460 3821880 A G1 -0.24 0.0070780 PTPRG 461 1713531 C G15 -0.25 0.0043390 PTPRG 462 9683044 C N5 -0.35 0.0032220 PTPRG 463 7651505 G G1 0.28 0.0023500 PTPRG 464 1388612 A G3 -0.33 0.0081380 PTPRG 465 1388613 C N5 0.38 0.0008341 PTPRG 465 1388613 C G3 -0.38 0.0006554 PTPRG 466 2242352 G N5 0.34 0.0012430 CADPS 467 1355551 T N5 0.43 0.0012130 CADPS 467 1355551 T N3 0.34 0.0022110 CADPS 468 9843019 T G3 -0.38 0.0018590 CADPS 469 9311842 T N6 0.32 0.0034610 CADPS 469 9311842 T N3 0.29 0.0029930 CADPS 469 9311842 T N5 0.37 0.0015880 CADPS 470 704356 T G9 -0.45 0.0033380 CADPS 471 13313979 A N2 -0.24 0.0095670 CADPS 471 13313979 A G9 -0.26 0.0065630 CADPS 472 12636581 A N6 -0.26 0.0081180 CADPS 472 12636581 A N2 -0.24 0.0072280 CADPS 474 17280557 A N6 -0.30 0.0075210 CADPS 475 17280571 T N6 -0.31 0.0033290 CADPS 475 17280571 T N2 -0.27 0.0050670 CADPS 476 17357618 C G8 -0.17 0.0075370 CADPS 476 17357618 C N6 -0.29 0.0058430 SYNPR 478 11130939 T G7 0.26 0.0068900 PRICKLE2 479 161661 A G7 0.21 0.0085940 PRICKLE2 479 161661 A N1 0.30 0.0034810

PRICKLE2 480 4994608 A P3 -0.30 0.0097530 MAGI1 481 9883580 G G12 1.01 0.0021390 MAGI1 482 2371948 A G8 0.50 0.0076160 MAGI1 482 2371948 A G12 0.93 0.0022050 MAGI1 482 2371948 A N7 0.67 0.0094890 MAGI1 483 9845819 C G8 -0.16 0.0094880 FAM19A1 486 1491748 A N7 0.23 0.0083170 FOXP1 487 2196356 C G14 0.17 0.0094540 FOXP1 488 2597312 C P7 0.17 0.0079850 FOXP1 489 2166780 T G8 -0.17 0.0052460 GBE1 490 7622741 G G15 0.27 0.0020670 GBE1 491 6769230 A G15 0.26 0.0031950 GBE1 492 2307058 T G15 0.26 0.0044090 GBE1 493 11922101 T N5 -0.77 0.0083960 GBE1 494 7613144 T G15 0.25 0.0064530 GBE1 496 3772899 G G8 -0.15 0.0097220 GBE1 497 3772891 A G8 0.20 0.0039690 GBE1 498 2680245 A N3 -0.24 0.0035420 HTR1F 500 1027689 T N3 0.37 0.0095000 EPHA6 501 12107680 T G4 -0.60 0.0086820 EPHA6 502 16838196 A G1 0.65 0.0014370 EPHA6 503 9848688 A G1 0.55 0.0074920 DKK2 504 447372 A G5 0.23 0.0018330 DKK2 505 379333 T N4 -0.44 0.0094420 PAPSS1 506 2189158 T G2 0.26 0.0026850 COL25A1 507 2305438 A G11 -0.23 0.0050050 COL25A1 510 3096489 C N5 0.50 0.0000011 COL25A1 511 3096490 A N5 0.50 0.0000011 ANK2 512 13134375 C N2 -0.23 0.0082630 ANK2 512 13134375 C N4 -0.26 0.0066540 ANK2 513 13107082 G N1 0.28 0.0047720 ANK2 513 13107082 G N6 0.25 0.0081860 ANK2 513 13107082 G G10 -0.17 0.0043110 ANK2 514 413019 C N1 0.28 0.0058060 ANK2 514 413019 C G10 -0.17 0.0054180 ANK2 514 413019 C N6 0.25 0.0085470 ANK2 515 29336 T P2 0.23 0.0092650 ANK2 515 29336 T G1 -0.30 0.0006090 ANK2 516 29329 T G1 -0.23 0.0066080 ANK2 518 29311 A G8 0.18 0.0070150 ANK2 518 29311 A P2 0.32 0.0024950 ANK2 518 29311 A G7 0.25 0.0050810 CAMK2D 519 11946664 G G14 -0.21 0.0025330 CAMK2D 520 10488894 C G14 -0.19 0.0052980 NDST3 522 6820367 A G14 -0.18 0.0064980 PRSS12 523 883686 C P1 -0.31 0.0038050 PRSS12 523 883686 C G2 -0.28 0.0010810 GPR103 524 11732033 A G7 0.23 0.0085620 MAML3 526 2246759 G G4 -0.23 0.0056290 IL15 527 17007695 C G2 0.43 0.0078580 INPP4B 528 2667101 G N5 0.30 0.0042020 INPP4B 529 2667108 C G8 0.66 0.0004086 INPP4B 529 2667108 C G13 0.67 0.0081900 INPP4B 530 336378 T N3 0.84 0.0010640 INPP4B 530 336378 T G11 0.97 0.0000950 INPP4B 530 336378 T N7 0.64 0.0082390 INPP4B 531 1353603 A G10 0.42 0.0079750 INPP4B 531 1353603 A N3 0.67 0.0021800 INPP4B 532 336329 G G13 0.67 0.0081900 INPP4B 532 336329 G N3 0.82 0.0025920 INPP4B 532 336329 G G11 0.88 0.0008613 INPP4B 532 336329 G G8 0.66 0.0004086 INPP4B 534 2276942 A P5 0.42 0.0059510 INPP4B 537 2627802 T P5 -0.24 0.0055920 POU4F2 538 1979903 C G7 -0.47 0.0040450 LDB2 539 2135442 A N5 0.31 0.0041740 LDB2 540 12500134 A N5 0.33 0.0076190 FSTL5 541 4501178 C G2 0.32 0.0064200 FSTL5 541 4501178 C G4 0.33 0.0019340 FSTL5 542 17041222 G G7 0.25 0.0093290 FSTL5 548 7699959 A G12 0.26 0.0066450 FSTL5 548 7699959 A N3 0.25 0.0038910 FSTL5 548 7699959 A G7 0.21 0.0079750 FSTL5 549 10031537 T N3 0.25 0.0022850 FSTL5 549 10031537 T G7 0.20 0.0084240 FSTL5 550 1994770 G N3 -0.24 0.0037350 FSTL5 551 13101933 T G3 -0.36 0.0099150 LDB2 552 157631 G G8 0.29 0.0070260 LDB2 554 1990280 G N3 -0.22 0.0062200 LDB2 554 1990280 G G13 -0.20 0.0070020 LDB2 555 992704 T N3 -0.26 0.0038550 LDB2 556 13110882 G P5 0.23 0.0062780 LDB2 556 13110882 G N3 -0.22 0.0062690 LDB2 556 13110882 G N6 -0.33 0.0003358 PALLD 558 10009393 G G10 -0.19 0.0031440 PALLD 559 17054309 A G16 -0.34 0.0063510 PALLD 560 10009813 G G10 -0.17 0.0073640 PALLD 561 2319901 G N1 -0.27 0.0080660 PALLD 562 2712118 C G10 0.17 0.0063330 PALLD 563 2319900 T G10 0.16 0.0079250 PALLD 566 4425335 G N4 -0.30 0.0059900 PALLD 569 10033898 C G8 0.16 0.0065860 ODZ3 571 2675534 T P7 0.25 0.0007318 ODZ3 571 2675534 T P2 0.29 0.0065920 ODZ3 571 2675534 T N1 0.40 0.0007424 ODZ3 572 2675532 C P7 0.17 0.0086620 ODZ3 572 2675532 C N1 0.28 0.0082390 ODZ3 572 2675532 C G12 0.29 0.0030980 ODZ3 572 2675532 C N4 0.29 0.0030560 ODZ3 573 9312304 A G4 -0.24 0.0062270 ENPP6 574 6830766 G G7 -0.22 0.0058610 ENPP6 579 17584049 C G9 -0.26 0.0040030 CASP3 580 9685847 G G9 -0.28 0.0017520 CASP3 581 2720376 C G9 -0.27 0.0019420 SLIT2 582 1323068 A G16 -0.25 0.0092420 SLIT2 583 621806 C G4 -0.28 0.0008018 SLIT2 584 10516357 A G2 0.28 0.0044990 SLIT2 585 609535 A G4 -0.27 0.0008318 SLIT2 586 2168802 T G2 0.36 0.0006412 SLIT2 587 9992591 C G4 -0.28 0.0008484 PCDH7 588 12331633 C N6 0.23 0.0099580 KIAA1239 589 4585313 C G9 0.48 0.0068600 KIAA1239 591 2928297 A P1 -0.28 0.0082720 TBC1D1 594 13110318 A G5 -0.31 0.0076540 UBE2K 596 192779 A P3 0.48 0.0010760 UBE2K 597 1003212 T P7 0.25 0.0062240 LIMCH1 598 4343753 T P7 0.22 0.0029980 LIMCH1 598 4343753 T G8 0.18 0.0076530 LIMCH1 599 6447080 G G1 0.30 0.0012160 LIMCH1 600 6447081 G G1 0.28 0.0020740 LIMCH1 601 7671360 T G1 0.27 0.0034520 LIMCH1 602 4610372 G G1 0.26 0.0045040 LIMCH1 603 7683275 G G3 0.38 0.0007506 LIMCH1 604 4861118 A G1 0.24 0.0077590 LIMCH1 605 10026359 T N2 -0.31 0.0053650 LIMCH1 606 6811377 A G14 -0.17 0.0075290 LIMCH1 607 6821712 C N7 -0.25 0.0038440 LIMCH1 608 17444879 T P6 0.43 0.0081320 LOC389207 609 1597565 A G7 0.24 0.0099900 NPFFR2 610 6856651 T G8 0.19 0.0022320 NPFFR2 611 7654531 T G8 0.19 0.0025550 NPFFR2 612 6824703 C G8 0.18 0.0038090 NPFFR2 613 4694116 A N2 -0.89 0.0027320 NPFFR2 614 17775309 G P1 -0.33 0.0038050 NPFFR2 615 2365797 T N7 -0.28 0.0011530 NPFFR2 615 2365797 T G1 0.28 0.0036590 NPFFR2 615 2365797 T P3 0.34 0.0041650 SCARB2 616 17001533 C G12 -0.37 0.0078630 SHROOM3 617 10013334 T G2 -0.34 0.0057150 SHROOM3 618 344141 C G15 -0.24 0.0050660 SCD5 619 10014168 G P5 -0.28 0.0087720 SCD5 620 7679857 A N7 -0.34 0.0015940 SCD5 622 17006038 C N7 -0.34 0.0018380 HERC3 624 3796660 A P4 0.34 0.0090780 FAM13A1 625 12507401 C N4 0.35 0.0025900 SLC2A9 628 1401438 T P3 -0.39 0.0058430 PDLIM5 629 13435066 A G15 0.25 0.0023570 PDLIM5 629 13435066 A G10 0.15 0.0077160 SLC2A9 630 4481233 T N5 -0.39 0.0029370 PDLIM5 631 2433325 A G1 -0.32 0.0015350 PDLIM5 632 6812098 C G16 0.46 0.0001203 PDLIM5 632 6812098 C N4 0.36 0.0035100 PDLIM5 632 6812098 C N2 0.34 0.0021210 PDLIM5 633 3805274 A N2 0.26 0.0086370 PDLIM5 634 2452593 G G16 0.37 0.0003595 PDLIM5 635 11735212 A G16 0.31 0.0009057 PDLIM5 635 11735212 A P6 0.29 0.0036940 PDLIM5 636 7689746 A G1 -0.35 0.0044080 SLC2A9 637 13111638 T N5 -0.36 0.0035700 SLC2A9 638 3733588 C G10 -0.18 0.0069930 SLC2A9 638 3733588 C G6 -0.29 0.0099750 SLC2A9 639 7669607 T N5 -0.34 0.0046140 SLC2A9 640 9291642 C N5 -0.38 0.0056060 SLC2A9 642 6820230 T G5 0.20 0.0090260 SLC2A9 643 7671266 T N5 -0.33 0.0072290 FBXL17 644 6871109 T G16 -0.26 0.0084320 FBXL17 645 286769 T P3 -0.36 0.0098200 FBXL17 646 11242664 G P3 0.38 0.0089410 FBXL17 647 4957551 T G3 -0.28 0.0095000 FBXL17 648 2416188 G P3 0.30 0.0067080 FBXL17 649 4957554 C P3 -0.32 0.0062560 FBXL17 650 2024528 A P1 0.29 0.0081400 FBXL17 651 1421972 G G3 0.35 0.0009893 PJA2 652 2963034 A G4 -0.22 0.0063020 PJA2 653 11957188 T P5 -0.64 0.0042340 PJA2 653 11957188 T G9 -0.65 0.0036440 KCNN2 655 337689 G G15 0.21 0.0084230 KCNN2 656 1072922 A N1 0.27 0.0096620 KCNN2 657 13163662 A N1 0.29 0.0070520 KCNN2 658 338625 T N1 0.26 0.0093140 KCNN2 659 4435855 A G5 -0.33 0.0009679 SEMA6A 660 254231 G G11 0.23 0.0033470 HSD17B4 661 6897978 G N3 -0.28 0.0075120 HSD17B4 662 246968 A G4 -0.25 0.0016710 SNCAIP 663 10052918 A G15 0.33 0.0012040 SNCAIP 664 7444144 G G15 0.32 0.0018020 SNCAIP 665 17149128 G G15 0.41 0.0009740 SNCAIP 666 17149141 A G15 0.40 0.0015110 SNCAIP 667 304379 C N2 -0.23 0.0056100 SNX2 668 4343835 C P6 0.26 0.0091950 SNX2 669 12109789 G P3 0.32 0.0041350 SNX2 671 2407403 G G12 -0.26 0.0098520 SNX24 673 246286 T P6 -0.32 0.0023260 SNX24 674 246266 C P6 -0.32 0.0023640 SNX24 675 6866400 A P7 0.18 0.0085110 ADAMTS19 676 17163231 G G8 0.20 0.0066970 VDAC1 677 4958172 A G8 -0.23 0.0065340 TRPC7 678 7701815 C N1 0.27 0.0049180 TRPC7 678 7701815 C G8 0.16 0.0031180 TRPC7 679 6596300 T N1 -0.30 0.0019470 TRPC7 680 3777150 A N2 0.24 0.0049440 TRPC7 680 3777150 A N1 0.28 0.0055900 TRPC7 681 953096 C N1 -0.30 0.0036380 DNAH5 683 6554811 G G8 -0.16 0.0071830 DNAH5 684 7715811 T G15 -0.31 0.0015590 DNAH5 685 1502050 G G15 -0.31 0.0019200 DNAH5 686 10513155 A G12 0.26 0.0082530 DNAH5 686 10513155 A N3 0.24 0.0061840 DNAH5 686 10513155 A G11 0.23 0.0075800 DNAH5 686 10513155 A G15 0.28 0.0011570 DNAH5 687 7709692 C G15 -0.33 0.0022890 DNAH5 689 1445823 C P3 0.30 0.0060050 DNAH5 689 1445823 C G1 0.27 0.0031900 DNAH5 690 1530498 G G1 0.25 0.0054000 DNAH5 690 1530498 G G14 0.16 0.0094470 DNAH5 691 13154455 G G1 0.25 0.0072620 DNAH5 691 13154455 G G2 0.26 0.0043680 DNAH5 692 339424 T G1 0.28 0.0077300 GRIA1 693 1463748 A N1 -0.31 0.0016600 GRIA1 694 7735696 C N1 0.26 0.0083580 GRIA1 695 17518831 C N1 0.31 0.0018810 GRIA1 696 778822 C G4 -0.26 0.0048090 GRIA1 697 778825 A P4 -0.24 0.0019700 GRIA1 697 778825 A P5 -0.28 0.0025320 GRIA1 698 11953799 T G13 -0.23 0.0077120 GRIA1 699 4424038 G G15 -0.31 0.0019480 GRIA1 699 4424038 G G13 -0.36 0.0001153 GRIA1 700 11167640 C G15 -0.30 0.0025210 GRIA1 700 11167640 C G13 -0.36 0.0001515 GRIA1 701 7708391 A G15 -0.23 0.0085600 GRIA1 701 7708391 A G13 -0.27 0.0010290 GRIA1 702 4958351 A P2 0.26 0.0069350 GRIA1 703 10070447 T G9 -0.25 0.0077290 ODZ2 704 2337017 C P6 -0.37 0.0077140 ODZ2 704 2337017 C G13 -0.34 0.0019890 ODZ2 704 2337017 C G11 -0.32 0.0046270 ODZ2 704 2337017 C G14 -0.24 0.0073700 MYO10 705 428263 A P3 0.35 0.0019020 MYO10 706 388887 T P3 0.33 0.0032930 ODZ2 708 1421989 G G11 -0.28 0.0080900 ODZ2 708 1421989 G P2 -0.31 0.0091460 ODZ2 709 13158058 T P4 0.20 0.0081150 ODZ2 710 17069979 G P3 -0.52 0.0078660 ODZ2 711 6868169 G G9 0.24 0.0097920 ODZ2 711 6868169 G G15 0.23 0.0072560 MYO10 714 11133860 G P2 -0.31 0.0050130 BASP1 715 2956564 C G11 -0.22 0.0086320 PLEKHG4B 716 9312845 T N5 0.51 0.0004538 PLEKHG4B 718 6888246 T N5 0.48 0.0010580 PLEKHG4B 719 3853521 A N5 0.48 0.0012290 CDH10 721 7731953 T N1 -0.43 0.0041710

CDH10 722 3822429 T P7 -0.19 0.0027610 CDH10 722 3822429 T N2 -0.24 0.0054650 CDH10 722 3822429 T P6 -0.30 0.0025310 SLC45A2 723 35388 T N2 -0.22 0.0086070 C1QTNF3 725 17583316 C G13 -0.25 0.0031540 C1QTNF3 725 17583316 C N5 -0.31 0.0041570 C1QTNF3 726 301506 G P5 -0.23 0.0094750 C1QTNF3 727 6898170 G G5 -0.19 0.0051580 C1QTNF3 727 6898170 G G13 -0.22 0.0049640 C1QTNF3 728 9292523 C N1 -0.32 0.0017980 C1QTNF3 728 9292523 C G5 -0.18 0.0083330 SLC1A3 729 2113099 C P3 0.32 0.0072760 EGFLAM 730 4869580 T N6 0.41 0.0032350 EGFLAM 730 4869580 T N3 0.35 0.0045490 EGFLAM 730 4869580 T N5 0.40 0.0080270 EGFLAM 731 2589787 A N5 0.48 0.0094900 EGFLAM 732 2886890 C N5 0.31 0.0021350 AHRR 733 2721012 G N2 0.31 0.0013310 AHRR 735 2672734 C N1 -0.27 0.0092760 EXOC3 736 2561667 T N1 -0.27 0.0099230 ITGA1 737 1820167 A N5 -0.29 0.0044460 ITGA1 738 12520591 G P3 0.57 0.0094040 ITGA2 740 3212576 G N4 0.32 0.0093410 ITGA2 741 7719848 A N4 0.26 0.0095610 PDE4D 742 2910641 A N7 -0.29 0.0064530 PDE4D 743 258125 T G6 0.25 0.0072690 ELOVL7 744 4541610 T N7 0.42 0.0082400 ELOVL7 745 4482855 C G10 -0.16 0.0060400 ELOVL7 746 6449505 C P3 -0.42 0.0015620 ELOVL7 747 4700397 A G10 0.17 0.0040410 ELOVL7 748 17332824 C G10 0.19 0.0013010 TNPO1 749 153320 T G8 0.22 0.0024000 TNPO1 749 153320 T P3 -0.43 0.0021820 TNPO1 750 34653 T P3 -0.41 0.0031040 TNPO1 751 266444 C P3 -0.40 0.0047670 TNPO1 751 266444 C G8 0.20 0.0066290 FCHO2 752 185435 G P3 -0.42 0.0033610 CMYA5 754 6880680 C N1 0.44 0.0078380 CMYA5 755 3828611 G G4 0.51 0.0004989 THBS4 756 256447 C N1 -0.33 0.0088410 THBS4 757 256444 C N1 -0.32 0.0097460 THBS4 758 1866389 C P4 -0.26 0.0037190 VCAN 759 11749904 C G1 -0.24 0.0069440 VCAN 760 188703 T G2 -0.25 0.0095740 MEF2C 761 304151 C G16 0.27 0.0051420 MEF2C 762 17560451 C G8 0.19 0.0096180 GPR98 763 16868901 C G9 0.35 0.0056920 GPR98 764 16869032 A G9 0.38 0.0094120 GPR98 765 12519770 A P7 -0.20 0.0011720 GPR98 766 2247870 C P7 -0.19 0.0028700 GPR98 767 3098356 C P7 -0.18 0.0080740 SEMA5A 768 985723 A N4 0.36 0.0078940 SEMA5A 770 11134354 A G4 -0.28 0.0051780 SEMA5A 770 11134354 A P6 -0.31 0.0097070 SEMA5A 771 4702625 G G3 -0.39 0.0015410 SEMA5A 772 268481 C G10 -0.26 0.0039070 CAST 774 11135479 C G4 0.24 0.0053220 SLC22A16 776 2428175 A G11 0.27 0.0070460 HS3ST5 777 12211751 A G9 0.37 0.0049540 TRDN 781 1431284 G P2 0.30 0.0017680 TRDN 782 17686735 G P2 0.29 0.0024370 TRDN 783 873460 T P2 0.26 0.0054160 TRDN 784 17085362 T G15 0.23 0.0092100 TRDN 785 7452290 C P6 -0.39 0.0024190 TRDN 786 9490794 T P6 -0.36 0.0076160 TRDN 787 10499125 T G2 -0.33 0.0002309 TRDN 788 2317707 T G2 -0.30 0.0013080 TRDN 789 7453704 C G11 -0.23 0.0094070 TRDN 790 2169092 T G2 -0.22 0.0097970 NKAIN2 791 12195023 T G16 -0.27 0.0090830 NKAIN2 792 6939050 A G14 -0.20 0.0021930 NKAIN2 793 6910988 T N3 -0.22 0.0066830 NKAIN2 794 1832252 G N4 0.25 0.0075970 NKAIN2 795 1871329 C G4 -0.30 0.0011400 NKAIN2 796 1031881 C G15 -0.31 0.0041450 NKAIN2 796 1031881 C P2 -0.34 0.0046210 NKAIN2 800 781487 C P5 0.53 0.0003526 NKAIN2 800 781487 C P3 0.52 0.0051620 NKAIN2 800 781487 C G8 0.28 0.0031870 PHACTR1 801 6458439 C N7 0.23 0.0046730 PHACTR1 802 9395497 G G16 -0.34 0.0007332 PHACTR1 803 12527257 C G16 -0.33 0.0011440 PHACTR1 804 9367368 C G16 -0.31 0.0018350 EYA4 805 2327321 G N5 -0.53 0.0000173 EYA4 806 9321396 G N5 -0.49 0.0000361 EYA4 807 9375953 A N5 -0.40 0.0014550 EYA4 808 2027210 A N3 -0.24 0.0049670 PDE7B 809 6906788 T N5 -0.54 0.0057170 PDE7B 810 6570049 T G9 -0.67 0.0019710 PDE7B 811 6931583 C G10 0.38 0.0055780 PLAGL1 812 9321951 T P5 -0.30 0.0023360 PLAGL1 813 6916498 A P5 -0.38 0.0003815 PLAGL1 814 9484836 A P5 -0.38 0.0003871 UTRN 815 601873 A N4 -0.26 0.0066050 UTRN 816 656471 C G10 0.19 0.0032640 SYNE1 819 718527 A G3 0.34 0.0005636 SYNE1 819 718527 A N7 0.21 0.0091670 JARID2 820 13192234 A P4 0.24 0.0055470 SLC22A3 821 376563 T P2 -0.26 0.0033320 PARK2 822 2003713 A G10 0.15 0.0090390 PARK2 823 6455738 A G10 0.16 0.0052030 PARK2 824 9365311 C G15 -0.23 0.0048690 PARK2 825 9355924 A N6 -0.26 0.0075820 PARK2 825 9355924 A G7 -0.22 0.0060100 PARK2 826 7750426 G N5 -0.28 0.0044080 PARK2 827 9295173 G N5 0.29 0.0036830 PARK2 828 10945823 A G5 0.20 0.0093000 PARK2 828 10945823 A N2 0.28 0.0049730 PARK2 830 7750033 T N2 -0.26 0.0029560 PARK2 831 4636000 C N2 0.23 0.0073420 PARK2 832 2155510 G N2 0.22 0.0091110 PARK2 833 2846528 G N4 0.27 0.0042590 PACRG 834 7740626 G G13 0.23 0.0042910 PACRG 835 761625 A G9 -0.30 0.0007418 PDE10A 836 525643 A G5 0.25 0.0086370 PDE10A 837 566759 G G11 -0.31 0.0078720 PDE10A 837 566759 G N6 -0.35 0.0077690 PDE10A 838 484594 C P1 0.38 0.0089850 ATXN1 839 235147 A N4 -0.25 0.0076850 ATXN1 840 2237165 A N1 -0.26 0.0091670 ATXN1 842 11754887 C G10 -0.16 0.0096370 SLC17A4 843 1937131 A G1 0.26 0.0091520 SLC17A4 844 9358890 G P7 0.69 0.0000048 SLC17A4 844 9358890 G G14 0.48 0.0016380 SLC17A4 844 9358890 G G9 0.70 0.0009106 SLC17A4 846 1575535 T G1 0.28 0.0085140 SLC17A1 847 4712976 T P5 0.28 0.0088790 SLC17A2 849 442601 C G5 -0.19 0.0070930 BTN3A1 850 12208788 T P4 -0.31 0.0037000 BTN3A1 852 10946826 G P4 -0.28 0.0045120 BTN3A1 853 10447390 G P4 -0.27 0.0062400 BTN2A3 854 10946829 A P4 -0.27 0.0062400 BTN3A3 855 3846847 T P4 -0.28 0.0051800 BTNL2 856 4424066 G P2 0.27 0.0020450 BTNL2 857 2076533 A P2 0.27 0.0024150 BTNL2 858 2076530 G P2 0.23 0.0074490 SLC22A23 859 17136575 G G7 0.31 0.0025780 LRFN2 860 4714349 C G3 -0.27 0.0089060 LRFN2 860 4714349 C N3 0.24 0.0050500 LRFN2 861 9369205 A N3 0.24 0.0072610 LRFN2 861 9369205 A G12 0.28 0.0044510 LRFN2 862 1036288 A G8 -0.17 0.0038250 LRFN2 862 1036288 A G5 -0.20 0.0046120 LRFN2 863 403319 A G8 -0.16 0.0052610 PPP2R5D 864 3823423 A P1 0.56 0.0054740 KLC4 865 4714658 A P2 0.61 0.0064770 ELOVL5 866 9370196 C N5 0.34 0.0019440 ELOVL5 868 1429143 G N5 0.30 0.0087170 RIMS1 870 511211 C P3 -0.32 0.0032160 RIMS1 871 9446563 G N5 -0.27 0.0087340 RIMS1 871 9446563 G G3 0.28 0.0058150 RIMS1 871 9446563 G P3 0.30 0.0077580 RIMS1 872 9293862 G P3 -0.29 0.0092360 RIMS1 872 9293862 G G1 -0.27 0.0024820 RIMS1 873 2496495 G P5 -0.24 0.0100000 RIMS1 874 2496517 C P5 -0.25 0.0086970 RIMS1 875 2463749 C G2 -0.24 0.0082510 RIMS1 875 2463749 C P3 -0.30 0.0075470 RIMS1 876 2254147 G G1 -0.27 0.0031340 RIMS1 877 1015945 G G6 -0.32 0.0020480 RIMS1 877 1015945 G P3 -0.36 0.0019480 RIMS1 878 11754022 T N5 -0.29 0.0093480 HTR1B 879 6296 C G7 -0.26 0.0027960 KLHL32 880 1206084 A G8 -0.18 0.0074420 KLHL32 881 1629523 T G8 -0.28 0.0024920 KLHL32 882 1737646 A G8 -0.26 0.0040920 KLHL32 883 1206149 A G13 -0.25 0.0009723 CUX1 886 2694158 T G14 0.22 0.0011170 CADPS2 887 2471212 G P7 0.27 0.0004120 CADPS2 890 2251761 G P7 0.24 0.0007916 CADPS2 891 2159827 A P7 0.23 0.0010370 CADPS2 892 2428769 G G9 -0.25 0.0074430 CADPS2 892 2428769 G N7 -0.26 0.0016860 GRM8 893 1989850 C G15 -0.24 0.0037200 GRM8 894 954661 T G15 -0.24 0.0050950 GRM8 895 2283079 G G15 -0.23 0.0065480 GRM8 896 2283062 G P2 0.34 0.0004788 GRM8 897 2283064 C G15 0.23 0.0056490 GRM8 898 6950264 G G15 0.24 0.0061690 GRM8 898 6950264 G G4 -0.25 0.0034660 GRM8 898 6950264 G G7 0.24 0.0045350 GRM8 899 13240418 G G15 -0.24 0.0037280 GRM8 900 4731330 C G15 -0.24 0.0039610 GRM8 901 6975541 T G15 -0.21 0.0097330 GRM8 902 1419442 T G2 0.23 0.0089740 GRM8 903 2106183 T G7 0.28 0.0010190 GRM8 904 916597 C G4 0.25 0.0074300 EXOC4 905 7786489 A G6 0.40 0.0008424 EXOC4 905 7786489 A N4 0.33 0.0047400 EXOC4 906 7778778 G G6 0.41 0.0006110 EXOC4 906 7778778 G N4 0.35 0.0032260 EXOC4 907 1946303 T N4 0.31 0.0085270 EXOC4 907 1946303 T G6 0.40 0.0009938 EXOC4 908 11980047 A N4 0.31 0.0091850 EXOC4 908 11980047 A G6 0.37 0.0017280 EXOC4 909 6975109 T G6 0.36 0.0021400 EXOC4 910 6954842 A G11 0.24 0.0072040 EXOC4 910 6954842 A N4 0.39 0.0002372 EXOC4 910 6954842 A N2 0.26 0.0055730 EXOC4 911 12707127 A G13 -0.22 0.0050630 EXOC4 912 6970436 A G13 -0.20 0.0084370 EXOC4 913 4731992 A G6 0.30 0.0076580 EXOC4 914 6950383 C N4 -0.23 0.0099900 DGKI 915 16874961 C G12 -0.28 0.0063030 DGKI 915 16874961 C G9 -0.32 0.0009730 DGKI 916 980796 A G9 -0.29 0.0029290 CREB3L2 917 273981 C P6 0.27 0.0055160 CREB3L2 918 273988 A P6 0.27 0.0058800 TBXAS1 920 2270163 G G16 -0.28 0.0013640 TBXAS1 921 4590360 G N4 -0.27 0.0033670 TBXAS1 922 12534299 G N4 -0.26 0.0042550 TBXAS1 923 41723 G N2 0.34 0.0044530 TBXAS1 923 41723 G G7 0.29 0.0087490 TBXAS1 923 41723 G N6 0.39 0.0025320 CNTNAP2 925 1639480 T G12 0.26 0.0060870 CNTNAP2 925 1639480 T P2 0.27 0.0041550 CNTNAP2 926 1639481 G P2 0.31 0.0006389 CNTNAP2 927 986264 A P2 0.30 0.0009067 CNTNAP2 928 6963627 T P2 0.32 0.0005588 CNTNAP2 929 1639484 T P2 0.29 0.0012660 CNTNAP2 930 12535047 T G8 -0.17 0.0056230 CNTNAP2 931 11972784 C P1 0.32 0.0098660 CNTNAP2 933 2022226 C G16 0.25 0.0078870 CNTNAP2 934 10952682 G P1 0.35 0.0051770 CNTNAP2 935 6953679 A G5 0.20 0.0099500 CNTNAP2 936 700320 A G13 0.25 0.0046060 CNTNAP2 938 6958824 A N7 0.33 0.0026150 CNTNAP2 939 1637840 T G3 -0.49 0.0003246 PTPRN2 940 1049325 T N4 -0.54 0.0015840 PTPRN2 940 1049325 T G16 -0.44 0.0085630 PTPRN2 941 4909289 A G7 -0.25 0.0042670 PTPRN2 942 2335836 C G6 -0.29 0.0042990 PTPRN2 943 10265417 T P2 -0.24 0.0084970 STK31 944 12532929 T N7 0.38 0.0002619 STK31 945 7791283 C P2 0.28 0.0084170 SKAP2 946 3801846 A G1 -0.32 0.0022280 SKAP2 947 13438513 C G1 -0.29 0.0049670 SKAP2 948 13438514 A G1 -0.29 0.0055540 SKAP2 949 17315929 T G1 -0.27 0.0089990 SKAP2 950 10486483 A G1 -0.27 0.0095690 CREB5 951 177486 A G6 0.26 0.0062190 CREB5 952 2237361 C G2 -0.28 0.0018250 CREB5 953 1544469 G P7 -0.20 0.0048410 CREB5 954 17669844 C G7 0.21 0.0091950 CREB5 954 17669844 C G2 -0.30 0.0011890 CREB5 955 4722864 A P5 0.35 0.0034100 CREB5 956 886750 A P7 -0.19 0.0086880 CREB5 956 886750 A P1 0.33 0.0077470 CARD11 957 3735131 C G14 0.53 0.0047800 CHN2 958 7781003 T G6 -0.35 0.0006594 CHN2 959 3750103 C G5 0.43 0.0017980

SCRN1 961 13834 T N1 -0.29 0.0056070 SCRN1 962 6976789 T N1 -0.28 0.0070480 SCRN1 963 1465327 T N1 -0.33 0.0038670 CRHR2 965 2190242 C N3 0.34 0.0008023 CRHR2 965 2190242 C G15 0.32 0.0013330 CRHR2 966 4723003 T G1 0.46 0.0025620 FLJ22374 967 6956143 G P4 -0.26 0.0009240 FLJ22374 967 6956143 G P7 -0.18 0.0067100 FLJ22374 969 12690795 C G10 0.17 0.0035590 FLJ22374 970 10243139 C G4 0.40 0.0081700 FLJ22374 972 10229281 A G4 0.43 0.0051690 PDE1C 973 12701142 G G14 0.19 0.0067130 PDE1C 974 30589 G P4 -0.33 0.0032030 PDE1C 975 30586 A P4 -0.38 0.0017520 BMPER 976 6975236 T N2 0.27 0.0023920 BMPER 977 7802225 G P2 0.24 0.0071620 BMPER 978 12539069 G N7 -0.24 0.0034980 BMPER 979 7806522 C G8 -0.18 0.0027810 BMPER 979 7806522 C P2 -0.26 0.0077620 BMPER 979 7806522 C N2 -0.25 0.0060680 BMPER 979 7806522 C P7 -0.18 0.0068380 BMPER 980 4140982 A G8 -0.21 0.0007372 BMPER 980 4140982 A G10 -0.17 0.0070920 BMPER 980 4140982 A N2 -0.26 0.0051770 BMPER 981 12672492 A G8 -0.18 0.0051760 BMPER 982 969363 C N6 -0.27 0.0059830 VPS41 984 3801127 T G14 -0.19 0.0031280 VPS41 985 10951578 G G14 0.18 0.0053030 VPS41 986 859522 G N6 0.41 0.0065930 CDC2L5 987 10272641 G P6 0.28 0.0041930 CDC2L5 987 10272641 G N4 0.29 0.0024270 CDC2L5 988 10277422 C N4 0.33 0.0028310 CDC2L5 989 9639817 T G2 0.23 0.0095010 CDC2L5 989 9639817 T N4 0.34 0.0003946 CDC2L5 990 17171658 T P6 0.27 0.0076810 CDC2L5 990 17171658 T N4 0.31 0.0012590 SDK1 992 4723505 T P6 -0.25 0.0097690 SDK1 993 1044701 A G14 -0.17 0.0090940 IGFBP3 994 10282088 A P5 0.38 0.0022290 IGFBP3 995 13223993 A P5 0.33 0.0033910 IGFBP3 996 10499637 A G7 0.28 0.0050940 ABCA13 997 6943725 A G15 0.25 0.0019980 ABCA13 998 17132289 T P2 -0.47 0.0086710 ABCA13 999 17729627 A P2 -0.28 0.0093140 ABCA13 1000 17662118 A P2 -0.31 0.0088530 ABCA13 1002 9642323 T G8 -0.22 0.0090370 WBSCR17 1005 10950221 A G9 0.28 0.0017610 WBSCR17 1007 10950251 A G1 0.29 0.0012950 WBSCR17 1009 12666361 A G1 0.24 0.0055900 WBSCR17 1010 1012127 T G11 -0.27 0.0053600 LIMK1 1011 2855726 A N6 0.30 0.0031480 GTF2IRD1 1014 2267834 G P4 0.23 0.0069550 HIP1 1015 2260429 A G6 -0.26 0.0064490 HIP1 1016 2696213 T G6 -0.28 0.0051910 HIP1 1017 2253020 G G6 -0.26 0.0081350 HIP1 1018 2285875 G G7 -0.31 0.0006662 MAGI2 1019 3807797 T G4 -0.28 0.0090180 MAGI2 1020 10238177 A P4 -0.21 0.0097590 MAGI2 1021 38103 A P5 0.26 0.0065150 MAGI2 1022 38111 G G3 0.28 0.0078920 MAGI2 1023 12531031 T G14 0.22 0.0082170 MAGI2 1024 848913 C G13 0.31 0.0045930 MAGI2 1025 6971099 T G13 0.28 0.0026290 MAGI2 1026 6954793 C N2 0.34 0.0073860 MAGI2 1029 10953851 T G4 -0.32 0.0067460 MAGI2 1030 9969364 C G4 -0.23 0.0041770 CACNA2D1 1032 12535840 G N6 -0.27 0.0047260 CACNA2D1 1033 258728 A G7 -0.27 0.0025660 CACNA2D1 1033 258728 A N6 -0.29 0.0069820 CACNA2D1 1034 2059037 C G2 0.35 0.0049850 CACNA2D1 1034 2059037 C G7 -0.41 0.0002072 CACNA2D1 1034 2059037 C N3 -0.34 0.0044630 CACNA2D1 1034 2059037 C N6 -0.40 0.0028950 CACNA2D1 1034 2059037 C G10 -0.22 0.0082140 PCLO 1035 10954689 T G7 0.22 0.0039160 PCLO 1041 9656532 A N5 -0.29 0.0072800 PCLO 1042 2715148 A G13 0.21 0.0059090 PCLO 1042 2715148 A G7 0.21 0.0067400 PCLO 1043 2522833 C G13 0.22 0.0050570 PCLO 1043 2522833 C G7 0.22 0.0041040 PCLO 1044 2371214 C G13 0.23 0.0029330 PCLO 1045 2522843 A G13 0.22 0.0054520 PCLO 1045 2522843 A G7 0.21 0.0059480 PCLO 1047 1986742 G G13 -0.20 0.0072170 PCLO 1048 17282763 C N5 -0.27 0.0079140 PCLO 1049 12539066 T P3 -0.32 0.0097250 PCLO 1050 12531615 C G6 -0.29 0.0016810 PCLO 1051 17157155 T G6 -0.28 0.0027380 PCLO 1053 16887406 G G6 -0.28 0.0028090 PCLO 1054 4129230 T P1 0.36 0.0018800 PCLO 1054 4129230 T N7 0.28 0.0009215 PCLO 1054 4129230 T P6 0.32 0.0026010 PCLO 1054 4129230 T G5 0.20 0.0077110 PCLO 1054 4129230 T G9 0.30 0.0018250 SEMA3A 1058 11978893 G N5 -0.35 0.0029920 SEMA3E 1059 169992 C N4 -0.27 0.0063570 SEMA3E 1060 3801562 C G1 0.24 0.0080620 SEMA3E 1061 1972459 C G13 -0.23 0.0066110 SEMA3A 1063 6965990 A P3 0.30 0.0071050 SEMA3A 1063 6965990 A N4 0.27 0.0045080 SEMA3A 1063 6965990 A N2 0.23 0.0062760 SEMA3A 1064 11976072 T P3 0.29 0.0099500 SEMA3A 1064 11976072 T N4 0.26 0.0054950 SEMA3A 1065 13228082 G N2 0.22 0.0090980 SEMA3A 1065 13228082 G N4 0.25 0.0076380 NXPH1 1071 970526 G G11 0.24 0.0085230 ABCB4 1072 2097937 G N3 -0.29 0.0079540 ABCB4 1073 31662 A G4 -0.39 0.0022740 ADAM22 1075 17255978 A G1 0.69 0.0015120 ADAM22 1076 1688886 G G16 0.25 0.0094840 ADAM22 1076 1688886 G P6 0.46 0.0000073 ADAM22 1078 2282949 C P6 0.42 0.0000409 ADAM22 1078 2282949 C P1 0.41 0.0002684 ADAM22 1079 6951172 T P5 0.30 0.0013760 ADAM22 1079 6951172 T G9 0.27 0.0041660 ADAM22 1079 6951172 T P1 0.33 0.0039290 ADAM22 1080 9632709 C P5 0.28 0.0021550 ADAM22 1080 9632709 C G9 0.26 0.0048850 ADAM22 1080 9632709 C P1 0.33 0.0042990 ADAM22 1081 2299199 G P1 0.32 0.0045500 ADAM22 1081 2299199 G G9 0.24 0.0091970 ADAM22 1081 2299199 G P5 0.26 0.0045860 ADAM22 1082 10268574 T G10 0.20 0.0099450 ADAM22 1083 4140919 G N7 0.32 0.0035660 ADAM22 1085 17150307 C G4 0.38 0.0024420 NXPH1 1086 6962955 A G1 -0.24 0.0085140 NXPH1 1086 6962955 A G13 -0.25 0.0018330 PPP1R9A 1087 854535 C G5 0.23 0.0009944 PPP1R9A 1088 3917551 T G8 -0.31 0.0075500 PON1 1089 2158155 A G8 -0.30 0.0093400 PON1 1091 705378 T G1 0.24 0.0083890 DYNC1I1 1092 319329 G N5 0.30 0.0022040 GRHL2 1094 536022 G G11 0.40 0.0044060 GRHL2 1095 608337 C G11 0.39 0.0086210 GRHL2 1096 13275653 C G11 -0.24 0.0048940 GRHL2 1096 13275653 C N3 -0.27 0.0026210 GRHL2 1097 4734037 C G11 -0.27 0.0090110 NCALD 1098 1131862 G G12 -0.32 0.0048430 NCALD 1098 1131862 G N3 -0.30 0.0032540 NCALD 1098 1131862 G G11 -0.33 0.0006944 NCALD 1099 16868201 A G11 -0.30 0.0053330 NCALD 1100 2387620 G G5 -0.20 0.0075570 NCALD 1101 2226401 C G13 -0.27 0.0038330 NCALD 1101 2226401 C G5 -0.23 0.0049780 ZFPM2 1102 16873003 C G16 0.29 0.0070860 ZFPM2 1104 1481026 T G16 0.29 0.0074670 ZFPM2 1106 13280496 C P5 0.29 0.0024180 ZFPM2 1107 7003141 C P6 0.36 0.0010060 ZFPM2 1107 7003141 C P1 0.36 0.0028050 ZFPM2 1107 7003141 C G9 0.28 0.0040850 ZFPM2 1109 12546300 G G10 0.16 0.0073250 CSMD3 1115 7012235 C G8 0.53 0.0004453 CSMD3 1116 1382469 C P7 0.19 0.0095280 CSMD3 1117 720406 C P7 0.19 0.0098290 SAMD12 1120 7825963 A P5 0.30 0.0010170 SAMD12 1120 7825963 A P1 0.35 0.0025560 SAMD12 1121 4876840 A P5 0.29 0.0017730 SAMD12 1121 4876840 A P1 0.33 0.0039540 SAMD12 1122 7830423 C P5 0.23 0.0084430 FBXO32 1124 12548263 T P5 -0.32 0.0020230 FER1L6 1127 7838453 A G15 -0.24 0.0024640 FER1L6 1127 7838453 A N2 -0.22 0.0081370 FER1L6 1127 7838453 A G16 -0.29 0.0011000 FER1L6 1127 7838453 A G9 -0.22 0.0096400 FER1L6 1128 4537289 T G14 -0.26 0.0016260 FER1L6 1129 4478556 T G14 -0.24 0.0023000 FER1L6 1130 13279726 G G14 -0.21 0.0046370 FER1L6 1131 4242352 C G14 -0.19 0.0089120 FER1L6 1132 6981430 G G12 0.30 0.0023030 FER1L6 1133 7819868 G P1 0.31 0.0043000 FER1L6 1133 7819868 G P6 0.27 0.0052110 MTSS1 1137 6470252 C P6 -0.31 0.0027990 MTSS1 1137 6470252 C G1 -0.24 0.0097950 MTSS1 1138 4871503 C P6 0.38 0.0054270 DLC1 1139 2203838 C N3 -0.31 0.0056340 DLC1 1139 2203838 C N4 -0.36 0.0038230 DDEF1 1140 2670882 G N5 -0.40 0.0084760 ADCY8 1141 7016933 A G5 0.22 0.0014840 ADCY8 1142 7464362 G G1 0.24 0.0073450 ADCY8 1143 11781997 A G5 0.23 0.0004697 ADCY8 1143 11781997 A G2 0.24 0.0043980 ADCY8 1143 11781997 A N7 0.22 0.0043180 KCNQ3 1145 977939 A P3 0.31 0.0041890 ST3GAL1 1147 2978015 T G7 -0.24 0.0026210 ST3GAL1 1148 2945779 A G7 -0.21 0.0070080 ST3GAL1 1149 17722401 A G1 -0.25 0.0097290 COL22A1 1150 4475485 T G2 -0.40 0.0061060 COL22A1 1152 13279213 A P2 0.28 0.0068430 SGCZ 1153 1382147 A G2 -0.41 0.0013960 SGCZ 1154 11990657 T G5 0.22 0.0048200 SGCZ 1154 11990657 T G4 0.27 0.0029710 SGCZ 1155 13261120 C P3 0.38 0.0009172 SGCZ 1156 4427170 T P3 0.29 0.0093140 SGCZ 1156 4427170 T G6 0.29 0.0029130 SLC7A2 1157 2588222 A N4 0.27 0.0034900 SLC7A2 1158 2588223 T P6 0.29 0.0050040 PSD3 1160 1386688 G G4 -0.31 0.0038880 PSD3 1161 7837572 T G4 -0.32 0.0043610 PSD3 1162 13272436 G G14 -0.19 0.0070860 PSD3 1163 11782622 C G4 0.26 0.0038310 PSD3 1164 7007413 T G4 0.26 0.0012340 PSD3 1165 1492289 C G14 -0.17 0.0057410 PSD3 1166 4921968 A P7 -0.17 0.0077580 PSD3 1166 4921968 A G14 -0.20 0.0019750 PSD3 1167 6998537 G G9 0.42 0.0061480 PSD3 1168 11778310 G P7 -0.22 0.0019470 PSD3 1169 1506894 C G6 -0.47 0.0071880 ATP6V1B2 1170 952148 T G15 -0.40 0.0023880 GFRA2 1171 4077793 C P3 -0.38 0.0018170 PEBP4 1172 4872539 C G9 0.25 0.0090260 SLC25A37 1174 10503726 C G12 -0.36 0.0014890 SLC25A37 1175 11778179 T G12 -0.46 0.0004472 CSMD1 1176 622765 A G4 0.29 0.0064730 CSMD1 1177 7845140 G P7 0.37 0.0081810 CSMD1 1178 4875250 G G1 -0.32 0.0061320 CSMD1 1179 4487803 G G3 0.30 0.0036250 CSMD1 1181 17065959 C N3 -0.30 0.0088110 CSMD1 1183 12543159 T G3 0.27 0.0075310 CSMD1 1184 2938236 T P6 0.58 0.0047560 CSMD1 1184 2938236 T G16 0.53 0.0053610 UNC5D 1186 2589344 T N1 -0.34 0.0073910 UNC5D 1186 2589344 T N2 -0.29 0.0080970 UNC5D 1186 2589344 T N4 -0.35 0.0030110 UNC5D 1187 7826624 T N3 -0.26 0.0049960 SFRP1 1188 4736959 C P2 0.25 0.0089270 SNTG1 1193 318851 T G7 -0.49 0.0038520 SNTG1 1194 10504093 G G7 -0.47 0.0052210 SNTG1 1195 10957739 G G7 -0.27 0.0052140 SNTG1 1196 2106156 A G11 -0.27 0.0043320 MCPH1 1197 1530408 C G15 0.43 0.0000761 MCPH1 1197 1530408 C P4 0.33 0.0007420 MCPH1 1198 2916750 C P4 0.30 0.0023730 MCPH1 1199 1054073 T G15 0.32 0.0021200 MCPH1 1200 1868551 T P4 0.29 0.0036450 MCPH1 1201 2922818 T P4 0.29 0.0040630 MCPH1 1202 2920660 A G15 0.34 0.0024740 MCPH1 1203 2916741 G P4 0.29 0.0044610 MCPH1 1203 2916741 G G15 0.33 0.0029680 MCPH1 1204 2440399 C P4 0.26 0.0056170 MCPH1 1205 2442492 T G15 0.28 0.0070860 MCPH1 1205 2442492 T P4 0.26 0.0057890 NKAIN3 1206 4257998 A G8 0.22 0.0082730 MCPH1 1208 3020213 T G15 0.26 0.0026600 MCPH1 1208 3020213 T P2 0.29 0.0028620 MCPH1 1209 2515435 G G15 0.25 0.0042120 MCPH1 1209 2515435 G P2 0.27 0.0041080 NKAIN3 1210 1480194 C G12 0.36 0.0034440 NKAIN3 1211 1383154 A G7 -0.26 0.0084630 NKAIN3 1212 16929903 G N1 -0.32 0.0036450 NKAIN3 1213 11989852 A N3 0.46 0.0043540 NKAIN3 1214 17279355 G N3 0.39 0.0086890

NKAIN3 1214 17279355 G P7 0.31 0.0058880 MCPH1 1215 11998083 T G3 -0.26 0.0082850 DEPDC2 1217 6988386 C P3 0.47 0.0090370 DEPDC2 1218 2053140 A G8 -0.16 0.0065190 DEPDC2 1219 6990381 T P3 0.29 0.0092950 DEPDC2 1219 6990381 T N5 0.31 0.0020080 DEPDC2 1219 6990381 T N1 0.27 0.0055850 DEPDC2 1220 2380437 T N5 0.31 0.0025060 DEPDC2 1221 16934215 A G6 0.44 0.0024850 DEPDC2 1222 3793381 A G6 0.41 0.0041560 DEPDC2 1223 7821308 A P7 -0.19 0.0057980 DEPDC2 1224 10808759 C P7 -0.18 0.0057040 KCNB2 1225 349358 G N5 -0.37 0.0061060 KCNB2 1226 349355 T N5 -0.37 0.0066520 KCNB2 1228 2256431 A G7 -0.23 0.0049940 KCNB2 1229 1972888 C G7 -0.25 0.0022710 KCNB2 1230 2196904 C G7 -0.22 0.0073420 MMP16 1233 278887 C P7 -0.19 0.0068410 MMP16 1234 2664370 C P7 -0.18 0.0071640 MMP16 1235 2616493 C G5 0.23 0.0038820 MMP16 1235 2616493 C N1 0.31 0.0063300 MMP16 1236 6994019 T N7 -0.24 0.0089210 MMP16 1239 4961087 C N3 -0.29 0.0015200 MMP16 1240 10504845 T N3 -0.28 0.0062940 MMP16 1241 4548227 A N3 -0.28 0.0019820 GABBR2 1244 2778913 T G4 -0.36 0.0043020 GABBR2 1244 2778913 T G15 -0.37 0.0040610 GABBR2 1245 1930139 G G12 -0.29 0.0092010 RP11-35N6.1 1246 10989207 T G15 0.22 0.0085370 GRIN3A 1247 7023041 A G12 0.41 0.0004123 GRIN3A 1248 10989589 A N5 -0.28 0.0069490 GRIN3A 1249 4615635 T N5 -0.32 0.0018750 FKTN 1250 2768294 C P5 -0.28 0.0025840 FKTN 1251 885954 C G14 -0.18 0.0064680 FKTN 1252 635712 C G2 0.30 0.0009908 SVEP1 1253 963143 A G13 -0.21 0.0069400 SVEP1 1254 10759422 C P4 -0.27 0.0026430 SVEP1 1255 7875389 C P4 -0.23 0.0019450 CDK5RAP2 1256 2282168 C G11 -0.27 0.0083170 CDK5RAP2 1257 12238807 C P5 -0.42 0.0089250 CDK5RAP2 1258 10818467 C P5 -0.50 0.0082280 CDK5RAP2 1259 4837782 T P5 -0.51 0.0083630 DAB2IP 1261 10985431 T G14 0.27 0.0045700 RALGPS1 1262 561041 C G14 -0.20 0.0016520 RALGPS1 1263 665249 G G14 -0.19 0.0022890 RALGPS1 1264 1123684 T G14 0.22 0.0013510 RALGPS1 1265 10760473 G G14 -0.19 0.0024290 RALGPS1 1266 13298677 G G14 -0.21 0.0046150 SLC25A25 1267 4837235 A G12 0.37 0.0082150 SLC25A25 1267 4837235 A G2 -0.36 0.0060960 SLC25A25 1268 9695803 C N3 0.34 0.0042130 SLC25A25 1268 9695803 C G12 0.35 0.0087230 FREQ 1269 12003792 A G6 0.28 0.0086910 EXOSC2 1270 10901275 C P2 0.27 0.0074950 ABL1 1271 6597642 A P2 -0.42 0.0018260 ABL1 1272 1800609 C P2 -0.38 0.0044690 ABL1 1274 3824400 A P2 -0.37 0.0056390 VAV2 1277 2519102 G G2 -0.27 0.0079990 OLFM1 1279 542172 A G15 0.39 0.0096740 OLFM1 1279 542172 A G11 0.61 0.0000435 OLFM1 1279 542172 A G13 0.39 0.0062000 INPP5E 1280 3812591 C N6 0.32 0.0021870 NOTCH1 1281 3013304 C G2 -0.26 0.0052680 CACNA1B 1282 2278975 C G10 1.19 0.0023780 CACNA1B 1283 7860423 A G10 0.20 0.0097920 ASAH3L 1284 12335928 A G10 -0.17 0.0082630 KIAA1797 1285 12338810 T G6 -0.34 0.0076580 KIAA1797 1285 12338810 T G3 -0.37 0.0047610 KIAA1797 1286 12336110 A G3 -0.37 0.0060610 KIAA1797 1286 12336110 A G6 -0.34 0.0085570 KIAA1797 1287 7021708 G G1 0.26 0.0049190 KIAA1797 1288 16938162 C G7 0.23 0.0041240 KIAA1797 1288 16938162 C N1 0.37 0.0003204 KIAA1797 1289 10511687 G N1 0.35 0.0005773 KIAA1797 1289 10511687 G G13 0.26 0.0013150 KIAA1797 1289 10511687 G N3 0.28 0.0010380 KIAA1797 1289 10511687 G G11 0.22 0.0082980 KIAA1797 1289 10511687 G N6 0.31 0.0013040 KIAA1797 1289 10511687 G G7 0.23 0.0044350 KIAA1797 1290 10964719 T G2 -0.29 0.0014030 KIAA1797 1293 6475491 G G2 -0.29 0.0020350 KIAA1797 1294 10511693 G N5 0.30 0.0088380 KIAA1797 1294 10511693 G G15 0.29 0.0020850 KIAA1797 1295 4579612 C G2 0.29 0.0023610 KIAA1797 1297 7025851 G G2 -0.25 0.0060460 KIAA1797 1298 7030990 G P4 0.24 0.0062690 KIAA1797 1299 4977881 A G15 0.28 0.0021590 KIAA1797 1300 4468020 T G15 0.26 0.0051060 SMARCA2 1301 6475520 G G6 0.41 0.0067800 SMARCA2 1302 6475522 A G6 0.41 0.0089820 SMARCA2 1303 3793499 G G6 0.55 0.0001478 SMARCA2 1304 10116703 A N5 0.27 0.0066610 IFT74 1305 17694549 C G13 0.44 0.0068240 IFT74 1305 17694549 C G14 0.42 0.0018630 TEK 1309 12339867 C G11 -0.31 0.0058700 SLC1A1 1310 9886720 T N5 0.33 0.0043410 SLC1A1 1311 4742008 A N5 0.30 0.0065550 PIP5K1B 1314 2152647 T N3 0.23 0.0075090 PIP5K1B 1314 2152647 T N6 0.28 0.0026870 PIP5K1B 1315 1414949 T N3 -0.22 0.0082530 PIP5K1B 1315 1414949 T N6 -0.27 0.0046400 PIP5K1B 1316 11144133 T N6 0.27 0.0048250 APBA1 1318 10481751 T G13 0.23 0.0094210 TRPM3 1319 1932701 C N1 -0.42 0.0045100 TRPM3 1320 2275242 G P1 0.29 0.0085320 TRPM3 1320 2275242 G P5 0.25 0.0067130 TRPM3 1321 6560161 G N5 -0.30 0.0046320 TRPM3 1323 2993010 A N5 -0.34 0.0011450 TRPM3 1323 2993010 A N2 -0.23 0.0090390 TMC1 1324 6560297 T N5 -0.29 0.0061080 TMC1 1325 12347235 A N5 -0.36 0.0028060 TMC1 1326 2501914 T N5 0.30 0.0031990 PCSK5 1328 1029035 C N6 -0.28 0.0014380 PCSK5 1328 1029035 C N3 -0.21 0.0068430 PCSK5 1329 914367 T N7 -0.24 0.0049840 GNAQ 1330 1030828 A G13 -0.23 0.0056920 GNAQ 1331 2378100 G G7 -0.24 0.0016740 GNAQ 1332 10870048 T N3 -0.27 0.0093900 PTPRD 1333 1500326 T P5 -0.25 0.0072700 PTPRD 1334 7036240 A P5 -0.26 0.0044690 PTPRD 1334 7036240 A N3 0.24 0.0057980 NTRK2 1335 1187321 A N5 0.38 0.0065870 NTRK2 1335 1187321 A G8 0.24 0.0023610 DAPK1 1338 1927976 G G8 -0.19 0.0010070 DAPK1 1339 1927975 G G8 0.14 0.0098350 DAPK1 1340 1056719 G G13 0.22 0.0055050 SORCS3 1341 10884026 G P5 -0.31 0.0061140 SORCS3 1342 10884052 C P6 0.31 0.0020190 SORCS3 1343 2491377 T P6 -0.30 0.0098710 SORCS3 1344 2451498 C P6 -0.29 0.0098930 SORCS3 1346 1961640 C P6 0.27 0.0056240 SORCS3 1347 790663 T G12 -0.26 0.0060990 SORCS3 1348 2696864 A G12 -0.34 0.0008217 SORCS3 1349 10160134 A G12 0.30 0.0020400 SORCS3 1350 697189 C G12 0.29 0.0022860 SORCS3 1351 697190 C G12 0.27 0.0069240 SORCS3 1352 7072425 T G11 0.38 0.0061330 SORCS3 1352 7072425 T G13 0.37 0.0055370 CUGBP2 1353 3243 C G7 0.23 0.0084640 VTI1A 1354 10509963 A P3 -0.31 0.0093380 VTI1A 1355 10885352 T P3 -0.31 0.0099750 VTI1A 1355 10885352 T G16 -0.26 0.0098450 VTI1A 1356 11196051 G G3 0.29 0.0097550 VTI1A 1357 7907012 G N5 0.33 0.0023160 VTI1A 1358 7907540 A N5 0.30 0.0052170 VTI1A 1359 7068695 C N1 0.26 0.0082790 VTI1A 1360 4145776 G N1 0.29 0.0067390 HSPA12A 1361 3010460 C G8 0.17 0.0038730 HSPA12A 1362 735412 G G8 0.25 0.0097560 ATE1 1363 7086628 C P6 -0.31 0.0010380 ATE1 1363 7086628 C N3 -0.21 0.0087970 ATE1 1364 1219505 T P1 -0.28 0.0060540 ATE1 1364 1219505 T N3 -0.21 0.0080360 ATE1 1365 1693682 A P6 -0.32 0.0015320 ATE1 1365 1693682 A N3 -0.25 0.0029740 ATE1 1366 10732824 A G13 -0.38 0.0047450 ATE1 1366 10732824 A N7 -0.40 0.0036090 ATE1 1367 2420970 T P1 0.37 0.0004130 CTBP2 1370 4962718 C N5 0.29 0.0089980 ARMC3 1371 17440393 A G1 0.33 0.0020190 ARMC3 1371 17440393 A P1 0.47 0.0004260 ARMC3 1372 11013210 T G1 0.29 0.0074760 ARMC3 1373 7084413 C G6 0.30 0.0044130 ARMC3 1374 10828389 T G1 0.28 0.0055940 ARMC3 1374 10828389 T G6 0.30 0.0053160 ARMC3 1375 10828395 A G1 0.35 0.0015950 ARMC3 1376 7898656 A G1 0.34 0.0039890 ARMC3 1377 1382579 G P2 0.67 0.0014970 ARHGAP21 1378 7897303 A G1 -0.30 0.0055920 MYO3A 1379 7084614 T G4 -0.23 0.0096120 PITRM1 1381 2306310 C P7 -0.23 0.0089410 PITRM1 1382 9129 C P7 -0.23 0.0089410 PITRM1 1383 3740607 A G13 0.23 0.0027190 PITRM1 1385 7092621 A G13 0.26 0.0029930 SLC16A9 1386 6481469 A G4 0.56 0.0003589 SLC16A9 1387 3763747 C N6 -0.30 0.0062020 SLC16A9 1387 3763747 C N1 -0.31 0.0078040 PRKCQ 1391 661891 T N6 0.35 0.0001849 PRKCQ 1392 9423765 A N6 0.27 0.0051980 CDH23 1393 17635709 T G3 0.33 0.0067420 CDH23 1394 10999947 A G10 -0.20 0.0042540 CDH23 1395 7094357 A N3 0.24 0.0096950 KCNMA1 1396 2288840 G P7 0.19 0.0041030 KCNMA1 1397 10740460 A G6 -0.28 0.0095040 KCNMA1 1398 4639876 T G6 -0.27 0.0061470 KCNMA1 1399 7067873 C P4 0.22 0.0052870 KCNMA1 1399 7067873 C P7 0.18 0.0096960 KCNMA1 1400 1907729 T G6 -0.40 0.0046610 KCNMA1 1401 7897566 C N4 0.39 0.0000659 KCNMA1 1401 7897566 C N6 0.29 0.0025480 KCNMA1 1401 7897566 C N7 0.21 0.0083090 KCNMA1 1401 7897566 C G14 0.18 0.0049070 KCNMA1 1401 7897566 C G15 0.23 0.0059900 KCNMA1 1401 7897566 C G7 0.24 0.0024660 KCNMA1 1401 7897566 C G13 0.24 0.0024780 KCNMA1 1401 7897566 C G16 0.25 0.0068400 KCNMA1 1401 7897566 C G11 0.30 0.0003752 KCNMA1 1401 7897566 C P2 0.34 0.0002477 KCNMA1 1402 10824520 T G12 -0.29 0.0019630 KCNMA1 1403 11002121 A G12 -0.29 0.0025370 KCNMA1 1404 11002139 A G12 -0.30 0.0025480 KCNMA1 1405 1371457 A G12 -0.28 0.0033410 KCNMA1 1406 10824547 T G12 0.53 0.0005635 KCNMA1 1406 10824547 T N3 0.43 0.0015520 KCNMA1 1407 2719986 T P6 -0.30 0.0020550 NRG3 1409 10884538 T G5 -0.22 0.0071700 NRG3 1412 495978 A G15 0.26 0.0036690 SORBS1 1413 3814150 G N3 -0.27 0.0021460 SORBS1 1414 11188298 C G13 0.25 0.0020830 SORBS1 1415 11188299 C G6 -0.64 0.0065380 SORBS1 1416 4918921 G N3 -0.24 0.0053900 SORBS1 1416 4918921 G G13 -0.23 0.0051310 SORBS1 1417 1536556 A G13 -0.23 0.0034250 SORBS1 1418 540746 T G16 -0.25 0.0045690 ELMOD1 1419 683266 A P3 0.32 0.0073560 GALNTL4 1420 10831565 A G10 0.18 0.0018020 GALNTL4 1420 10831565 A G16 -0.23 0.0098840 GALNTL4 1421 7122801 T G16 -0.27 0.0065250 MICAL2 1422 10765929 T P1 -0.51 0.0000098 MICAL2 1423 2010463 A P1 -0.43 0.0000911 MICAL2 1424 11822285 T P1 -0.39 0.0002196 MICAL2 1425 7117024 G P1 -0.44 0.0002173 MICAL2 1426 17477949 T G13 -0.23 0.0034800 MICAL2 1427 2270511 G P1 0.41 0.0082260 OPCML 1429 3016384 A G8 0.15 0.0076470 ARNTL 1430 7107711 C N7 -0.26 0.0094590 OPCML 1433 7936263 G G15 0.27 0.0051090 OPCML 1433 7936263 G P2 0.28 0.0070530 OPCML 1434 7108751 T P2 0.29 0.0080810 SPON1 1435 1507527 C G6 0.29 0.0061720 SPON1 1436 2049723 C G6 0.34 0.0017820 SPON1 1437 1528668 C N3 0.25 0.0048540 SPON1 1438 7112850 A N3 0.24 0.0060470 SPON1 1439 10766134 G N3 0.23 0.0061030 SPON1 1440 10832170 T N3 0.22 0.0087010 SPON1 1440 10832170 T N2 0.25 0.0033110 SPON1 1440 10832170 T N4 0.25 0.0081060 SPON1 1441 1406356 A N2 0.27 0.0018150 SPON1 1441 1406356 A N4 0.26 0.0065680 SPON1 1442 7116296 T N2 -0.25 0.0045770 SPON1 1443 11023088 T N2 -0.24 0.0054460 SPON1 1444 4757244 A N5 -0.35 0.0021520 INSC 1445 1792571 A N1 0.33 0.0041810 INSC 1445 1792571 A N4 0.30 0.0058370 INSC 1445 1792571 A G7 0.24 0.0063900 INSC 1445 1792571 A N2 0.37 0.0001496 KCNA4 1446 11030913 C G9 0.36 0.0020210 KCNA4 1447 10835607 A G9 0.34 0.0027960 STIM1 1449 10835249 G P3 -0.36 0.0009898 STIM1 1450 2923944 G G15 0.22 0.0098320 81.99 mb 1454 2186693 T G5 -0.20 0.0074750

DLG2 1455 11233564 A P4 -0.49 0.0044530 DLG2 1456 11233565 C P2 -0.67 0.0013580 DLG2 1456 11233565 C N7 -0.52 0.0047130 DLG2 1456 11233565 C P4 -0.44 0.0097570 DLG2 1457 6592113 A N7 -0.26 0.0013040 DLG2 1457 6592113 A G11 -0.23 0.0046300 DLG2 1460 558211 G G6 0.26 0.0080380 DLG2 1461 635823 G G2 0.26 0.0048390 DLG2 1462 2514147 G G16 0.41 0.0067680 DLG2 1462 2514147 G G7 0.36 0.0051240 DLG2 1463 10898192 G N3 0.38 0.0049450 DLG2 1463 10898192 G G7 0.33 0.0076490 DLG2 1464 7928752 C N3 0.38 0.0089480 DLG2 1465 1945832 T P4 -0.37 0.0057640 DLG2 1466 6592202 C G9 -0.25 0.0055200 DLG2 1466 6592202 C N7 -0.21 0.0085500 DLG2 1467 4451754 A G9 -0.24 0.0093620 DLG2 1470 11234221 A G9 -0.23 0.0095600 DLG2 1470 11234221 A G11 -0.21 0.0093050 DLG2 1470 11234221 A N7 -0.22 0.0065310 DLG2 1470 11234221 A P6 -0.29 0.0034420 DLG2 1471 11234222 A N7 -0.21 0.0081670 DLG2 1471 11234222 A P6 -0.29 0.0038850 DLG2 1471 11234222 A N2 -0.25 0.0036900 DLG2 1473 11234225 T P3 -0.43 0.0001278 DLG2 1473 11234225 T G11 -0.21 0.0090030 DLG2 1474 6592211 A P3 -0.44 0.0000786 DLG2 1475 7101454 C P3 -0.41 0.0002288 DLG2 1476 582652 A N2 -0.34 0.0074060 CHST11 1477 1795849 G P4 -0.25 0.0037010 CHST11 1478 2055861 C P6 -0.25 0.0091200 CHST11 1479 1097245 G G9 0.24 0.0099240 PLA2G1B 1481 2701632 G P6 -0.38 0.0001323 LOC729025 1482 1913253 T G1 0.24 0.0054970 LOC729025 1483 1799491 T G1 -0.24 0.0067540 PIK3C2G 1484 10770343 C P6 0.28 0.0072800 PIK3C2G 1485 9300118 G P6 0.28 0.0034110 PIK3C2G 1486 11044057 A G6 0.45 0.0059650 PIK3C2G 1487 11044165 C G4 0.30 0.0003435 PIK3C2G 1487 11044165 C G7 -0.21 0.0090200 PIK3C2G 1488 10841059 A G10 -0.17 0.0058320 ITPR2 1489 10842708 G G2 -0.27 0.0093630 TMEM16B 1491 9645764 C N1 -0.31 0.0077220 LRP1 1492 1799986 T N5 -0.40 0.0047260 TMEM16B 1493 10774369 T G12 0.28 0.0036530 TMEM16B 1494 2277401 C G8 0.15 0.0088880 TMEM16B 1494 2277401 C G10 0.17 0.0041830 TMEM16B 1495 2159952 A G6 0.34 0.0005129 TMEM16B 1496 10849338 G G6 0.36 0.0012240 TMEM16B 1497 3782659 T G6 0.25 0.0093090 TMEM16B 1498 11063875 T G1 0.26 0.0063660 CNOT2 1500 1595410 C G1 0.26 0.0040450 CNOT2 1501 3817487 A N2 0.23 0.0070250 KCNC2 1502 10879888 G N1 0.35 0.0019800 KCNC2 1503 10735985 G N5 0.35 0.0008785 KCNC2 1503 10735985 G N6 0.28 0.0047040 KCNC2 1504 2471664 C N5 0.34 0.0063280 KCNC2 1504 2471664 C N7 0.26 0.0068700 KCNC2 1504 2471664 C G15 0.32 0.0017050 KCNC2 1504 2471664 C N3 0.29 0.0045910 KCNC2 1504 2471664 C G11 0.28 0.0042050 KCNC2 1504 2471664 C N6 0.37 0.0012390 KCNC2 1504 2471664 C N1 0.36 0.0028950 KCNC2 1505 4290307 T G11 0.29 0.0067140 NAV3 1506 11106732 G N4 0.29 0.0042190 NAV3 1507 939458 G N4 0.27 0.0059560 NAV3 1508 1677923 G N3 0.46 0.0015940 NAV3 1509 1677914 G N3 0.40 0.0057700 NAV3 1510 10859620 G G5 -0.19 0.0062940 NAV3 1511 1479027 G N3 0.36 0.0090810 NAV3 1511 1479027 G G4 0.34 0.0087190 NAV3 1512 11107419 T G2 -0.28 0.0040500 NAV3 1513 1012088 G N2 0.27 0.0039940 NAV3 1513 1012088 G G4 0.25 0.0060590 NAV3 1515 7295890 C G4 0.23 0.0087880 NAV3 1517 7139116 C N3 0.38 0.0017840 NAV3 1518 10777655 A N3 0.36 0.0027780 NAV3 1519 438209 A G13 -0.26 0.0054940 NALCN 1520 12863308 T G4 0.25 0.0033430 NALCN 1521 9300653 C G4 0.28 0.0015320 NALCN 1522 9582457 A G4 0.25 0.0033390 NALCN 1523 896560 T G2 0.27 0.0031740 NALCN 1525 479648 G G7 -0.20 0.0065120 NALCN 1526 9513866 G G2 0.26 0.0030020 NALCN 1526 9513866 G G4 0.25 0.0016280 NALCN 1527 9513873 C G4 0.21 0.0070890 NALCN 1528 9513875 G G4 0.20 0.0093640 NALCN 1529 9557622 G G3 -0.29 0.0022740 NALCN 1529 9557622 G G2 -0.22 0.0097580 ITGBL1 1531 1140605 T G14 -0.39 0.0023940 ITGBL1 1532 4772403 T G10 -0.17 0.0061000 ITGBL1 1534 9300686 G P1 -0.66 0.0075520 ITGBL1 1534 9300686 G G14 -0.38 0.0083450 FGF14 1537 7319796 A N4 -0.27 0.0063930 FGF14 1541 3916921 T G14 -0.17 0.0079030 MTIF3 1542 7334690 A N2 0.30 0.0019510 N4BP2L2 1543 206337 A G6 0.37 0.0019540 N4BP2L2 1544 1081796 A G4 0.29 0.0066550 N4BP2L2 1544 1081796 A P4 0.26 0.0078880 N4BP2L2 1545 169600 A G6 0.31 0.0056210 N4BP2L2 1546 208431 G G6 0.30 0.0075390 NBEA 1547 2247674 T G6 0.59 0.0028400 NBEA 1548 1197852 A G13 0.30 0.0056870 NBEA 1549 3794388 C G2 -0.34 0.0076090 NBEA 1549 3794388 C G12 0.40 0.0030910 NBEA 1550 275960 T N7 -0.27 0.0089030 NBEA 1551 9545075 C N7 -0.27 0.0093760 TRPC4 1552 9566247 C G7 0.23 0.0047640 TRPC4 1552 9566247 C G14 0.20 0.0028790 TRPC4 1553 9576332 G G15 0.23 0.0095400 TRPC4 1553 9576332 G G5 0.24 0.0010710 TRPC4 1553 9576332 G G14 0.20 0.0025250 TRPC4 1554 7336008 A N7 0.27 0.0012410 TRPC4 1554 7336008 A G7 0.22 0.0053720 TRPC4 1555 7338239 G G5 0.22 0.0017960 TRPC4 1555 7338239 G N7 0.24 0.0037660 TRPC4 1555 7338239 G G14 0.19 0.0039390 TRPC4 1555 7338239 G G7 0.21 0.0095930 TRPC4 1556 2181747 G G14 -0.23 0.0002923 TRPC4 1557 4943529 C G14 0.18 0.0045480 TRPC4 1557 4943529 C G5 0.18 0.0079780 TRPC4 1557 4943529 C N7 0.21 0.0094170 TRPC4 1559 1556541 C G14 -0.22 0.0010430 TRPC4 1559 1556541 C P7 -0.24 0.0003256 TRPC4 1560 1924378 A G5 -0.19 0.0069170 TRPC4 1561 9548076 A P4 0.26 0.0073400 TRPC4 1563 1538146 T P5 0.26 0.0060540 TRPC4 1563 1538146 T P2 0.45 0.0000059 TRPC4 1564 9594238 C P2 -0.37 0.0028640 TRPC4 1564 9594238 C G11 -0.31 0.0046340 TRPC4 1564 9594238 C P4 -0.27 0.0073630 FNDC3A 1565 4942796 T G11 0.22 0.0098170 FNDC3A 1565 4942796 T G15 0.23 0.0084670 FNDC3A 1566 2994379 G G12 0.37 0.0002755 FNDC3A 1567 2181539 G G15 0.23 0.0087220 FNDC3A 1568 1983805 G G12 0.36 0.0004063 KPNA3 1569 3903768 A G15 -0.22 0.0070320 PCDH17 1570 9527676 G N7 -0.24 0.0026590 PCDH17 1570 9527676 G N5 0.29 0.0032020 PCDH17 1571 9591821 A N5 -0.29 0.0042650 SLAIN1 1572 9530678 A G2 -0.31 0.0060950 GPC5 1580 9560813 T G7 0.21 0.0093730 GPC5 1581 634099 C G3 -0.29 0.0069480 GPC5 1581 634099 C G2 -0.27 0.0039700 GPC5 1582 10507992 T P4 0.27 0.0013220 GPC5 1583 17188557 G P4 0.24 0.0035120 GPC5 1584 913005 T G13 -0.23 0.0029440 GPC5 1584 913005 T N1 -0.26 0.0080970 GPC5 1585 9556229 G N6 0.44 0.0031230 GPC5 1586 6492630 A N3 -0.22 0.0092900 GPC5 1587 2148226 G G7 0.20 0.0088650 GPC5 1587 2148226 G N1 0.31 0.0020230 GPC5 1587 2148226 G N6 0.25 0.0085330 GPC6 1588 9516222 G G16 0.32 0.0060390 GPC6 1588 9516222 G G9 0.40 0.0004041 GPC6 1589 1323974 C G9 0.36 0.0013320 GPC6 1589 1323974 C G2 -0.32 0.0046990 GPC6 1590 4394948 C G6 -0.33 0.0010280 GPC6 1591 7987964 T G6 -0.31 0.0021180 GPC6 1592 7993501 C G6 -0.29 0.0041020 GPC6 1595 9561551 C P3 -0.41 0.0013940 GPC6 1595 9561551 C G12 -0.34 0.0017870 GPC6 1595 9561551 C G9 -0.29 0.0054850 GPC6 1596 9561558 G G14 0.29 0.0061680 NPAS3 1598 1290203 T G16 -0.27 0.0028010 NPAS3 1598 1290203 T G6 -0.25 0.0085470 NPAS3 1599 243291 G P2 -0.25 0.0051370 NPAS3 1600 243284 G P2 -0.25 0.0060460 NPAS3 1601 10133530 A G8 0.25 0.0005158 NPAS3 1601 10133530 A P7 0.22 0.0071150 NPAS3 1601 10133530 A G1 0.31 0.0066340 NPAS3 1602 6571604 C G4 -0.34 0.0019570 NPAS3 1602 6571604 C G2 -0.32 0.0080670 NPAS3 1602 6571604 C P3 -0.42 0.0046270 NPAS3 1603 6571605 A G4 -0.29 0.0061820 NPAS3 1604 7144144 C G11 -0.22 0.0050680 NPAS3 1605 2383521 C G5 0.18 0.0069980 NPAS3 1605 2383521 C G11 0.21 0.0096830 NPAS3 1606 11156807 T G15 0.22 0.0054810 NPAS3 1607 7152838 A G15 0.23 0.0099530 SLC25A21 1608 12185044 G G3 -0.51 0.0076230 SLC25A21 1609 1367029 A G10 -0.16 0.0056360 LRFN5 1610 8020273 G G4 0.23 0.0055820 LRFN5 1611 12884688 T G3 -0.33 0.0015010 GNG2 1612 4901168 A G12 -0.28 0.0086310 GNG2 1613 10138800 A G14 -0.18 0.0049000 GNG2 1614 12882906 G G13 0.22 0.0066200 GNG2 1615 10873056 G G16 -0.79 0.0008798 GNG2 1615 10873056 G G14 0.52 0.0015880 SAMD4A 1616 1307289 G G1 0.31 0.0092750 SAMD4A 1617 8006657 A G15 0.25 0.0040450 SAMD4A 1617 8006657 A P6 0.33 0.0010530 SAMD4A 1618 709939 C G4 0.28 0.0004590 SAMD4A 1618 709939 C P6 0.28 0.0039730 SAMD4A 1619 8021151 G G4 0.31 0.0001717 PPP2R5E 1620 10137202 C G7 0.32 0.0046730 PPP2R5E 1620 10137202 C G3 0.43 0.0027250 PPP2R5E 1621 972984 C P5 0.28 0.0092860 PPP2R5E 1621 972984 C N6 -0.43 0.0001646 PPP2R5E 1622 1255741 A N1 -0.28 0.0071480 PPP2R5E 1622 1255741 A N4 -0.29 0.0040290 PPP2R5E 1623 7154718 G P6 0.93 0.0045130 RGS6 1624 36318 G P6 0.28 0.0050200 RGS6 1624 36318 G G6 0.26 0.0074530 RGS6 1625 11158926 T P6 0.29 0.0028720 RGS6 1625 11158926 T G6 0.29 0.0018240 RGS6 1626 11623588 C G6 -0.26 0.0063130 RGS6 1627 12586968 G G8 0.19 0.0045030 RGS6 1628 10151019 A P5 0.32 0.0054910 RGS6 1629 847241 A N7 -0.22 0.0057730 RGS6 1630 765221 A G4 0.26 0.0030130 RGS6 1631 2283380 T G5 0.20 0.0057700 KCNK10 1632 12587003 C G6 0.29 0.0049450 KCNK10 1633 12185033 T P5 -0.24 0.0074730 RPS6KA5 1634 1152423 C N1 0.27 0.0093070 RPS6KA5 1636 1286148 C N1 0.33 0.0051490 RPS6KA5 1636 1286148 C N6 0.35 0.0017090 RPS6KA5 1636 1286148 C N3 0.27 0.0068710 RPS6KA5 1637 7156252 T P6 0.41 0.0000700 RPS6KA5 1638 1285989 G P6 0.31 0.0020140 RPS6KA5 1639 1075014 C P6 0.38 0.0003627 RPS6KA5 1640 11159988 C P6 0.36 0.0005594 RPS6KA5 1641 7492628 G P6 0.32 0.0022000 CCDC88C 1642 4904770 T P1 -0.41 0.0031170 CCDC88C 1642 4904770 T P3 -0.40 0.0040540 CCDC88C 1642 4904770 T G3 -0.36 0.0042010 CCDC88C 1643 8015982 C P1 -0.34 0.0055030 CCDC88C 1644 10131741 G P5 -0.27 0.0077650 CCDC88C 1644 10131741 G P1 -0.34 0.0060010 CCDC88C 1645 8008996 T P5 -0.26 0.0084630 CCDC88C 1646 8007791 A P1 -0.34 0.0061070 CCDC88C 1646 8007791 A P5 -0.26 0.0084630 CCDC88C 1647 11160004 C G6 0.33 0.0059360 BCL11B 1649 807567 C P4 0.28 0.0051440 BCL11B 1650 2614463 T P1 0.28 0.0097100 ATP10A 1652 10873606 A G3 0.26 0.0085920 RYR3 1653 2572189 T P4 -0.20 0.0080530 RYR3 1654 2572175 A G8 -0.16 0.0038570 RYR3 1654 2572175 A P4 -0.19 0.0088300 RYR3 1655 10519839 G G5 0.23 0.0007472 RYR3 1656 1390159 T G10 0.48 0.0009035 RYR3 1657 1495284 C G10 0.45 0.0010110 RYR3 1658 11638307 A G7 -0.27 0.0059210 RYR3 1659 8036377 A G7 -0.23 0.0069290 RYR3 1660 2043054 G N1 -0.39 0.0002070 C15ORF41 1662 11073189 G N7 -0.26 0.0058370 C15ORF41 1663 8024344 C G4 -0.33 0.0077180 C15ORF41 1665 2381888 T N7 -0.28 0.0023710 C15ORF41 1666 9302317 T N7 -0.25 0.0059890 C15ORF41 1667 1990659 A N7 -0.22 0.0076630 RASGRP1 1668 11855910 G G12 0.26 0.0097590

PLA2G4D 1669 776699 A N4 0.52 0.0035160 GLDN 1671 17648128 A P5 0.25 0.0069100 GLDN 1672 17648140 G P4 0.20 0.0090160 CGNL1 1673 12595188 G G8 0.21 0.0036450 CGNL1 1674 7182648 T N4 -0.37 0.0013360 CGNL1 1675 8034215 G N4 -0.30 0.0034690 CGNL1 1676 16977561 A N5 -0.42 0.0058780 CGNL1 1677 1620402 G G10 -0.20 0.0053030 CGNL1 1678 1623697 G G10 -0.19 0.0078490 RORA 1679 12914584 G G4 -0.24 0.0075730 RORA 1680 4774370 C N1 0.33 0.0092280 CLK3 1681 12441932 G N1 0.40 0.0069560 TBC1D2B 1683 8030999 G P3 0.52 0.0012850 TBC1D2B 1683 8030999 G G10 0.25 0.0041290 TBC1D2B 1683 8030999 G G14 0.27 0.0036100 TBC1D2B 1684 11634607 T N4 0.30 0.0024460 TBC1D2B 1684 11634607 T G11 0.29 0.0008413 ARNT2 1686 8041887 A G6 0.24 0.0090900 ARNT2 1687 4778835 G N4 -0.28 0.0088630 ARNT2 1688 4628923 C P1 -0.41 0.0007190 ARNT2 1688 4628923 C N4 -0.27 0.0099790 ARNT2 1689 11072931 T P1 -0.43 0.0034780 ARNT2 1690 7180510 G P1 -0.36 0.0040010 ARNT2 1691 4778615 T P3 -0.39 0.0086420 ARNT2 1691 4778615 T P1 -0.38 0.0098670 SH3GL3 1692 10520577 T P2 0.32 0.0021760 PCSK6 1693 11247300 A G15 0.32 0.0051620 GDE1 1695 12447418 G P5 0.30 0.0064830 A2BP1 1699 1476979 T G1 0.24 0.0059520 A2BP1 1700 11077043 G G1 0.24 0.0062720 A2BP1 1702 4289011 C G7 -0.27 0.0007420 HYDIN 1703 1424137 G N4 -0.31 0.0015820 A2BP1 1704 8055711 T G7 -0.26 0.0026420 HYDIN 1705 9939194 T N4 -0.30 0.0019340 A2BP1 1706 11860241 G G12 0.27 0.0049040 A2BP1 1707 1507031 A G10 0.16 0.0071550 WWOX 1708 8061908 C N7 -0.25 0.0027750 WWOX 1709 1922620 C N7 -0.23 0.0043490 WWOX 1710 2344926 G N7 -0.22 0.0088960 WWOX 1711 11641213 G P6 0.27 0.0060550 WWOX 1712 7184271 C P6 0.26 0.0079320 WWOX 1713 7201683 G G3 -1.14 0.0068500 MPHOSPH6 1714 7405231 C P5 0.24 0.0033010 MPHOSPH6 1715 8052512 T G6 -0.40 0.0021070 MPHOSPH6 1716 8047857 C G6 -0.37 0.0060150 MPHOSPH6 1717 4530129 C G6 -0.38 0.0088290 CDH13 1718 4598906 T G8 -0.17 0.0037190 CDH13 1719 11150496 T N7 0.24 0.0026140 CDH13 1720 4782734 T N7 0.22 0.0072300 CDH13 1721 9933935 T G3 0.27 0.0087900 CDH13 1723 4783293 C G3 0.27 0.0093560 CDH13 1724 7201829 T N7 0.27 0.0041410 CDH13 1725 11150517 T N1 0.36 0.0031150 CDH13 1726 1035569 G G14 -0.20 0.0040860 CDH13 1727 10514579 C G14 -0.20 0.0045860 CDH13 1728 11864731 A G14 -0.19 0.0026430 CDH13 1729 1833965 A N5 0.27 0.0098150 USP10 1731 744839 T N1 -0.30 0.0024100 USP10 1732 8060725 A N2 0.27 0.0031360 CRISPLD2 1733 2641697 C P7 0.19 0.0042800 CRISPLD2 1735 16974822 G G9 -0.31 0.0030320 CRISPLD2 1735 16974822 G P2 -0.28 0.0079670 CRISPLD2 1736 774205 G P4 0.22 0.0040940 CRISPLD2 1737 11149692 C P3 -0.34 0.0076950 CRISPLD2 1737 11149692 C P5 -0.34 0.0007284 CRISPLD2 1738 982994 T P4 0.21 0.0083490 CRISPLD2 1738 982994 T P5 0.24 0.0092360 CRISPLD2 1739 2646107 C P5 -0.27 0.0071640 DNAH9 1740 3744581 G P4 -0.23 0.0046180 DNAH9 1741 16945383 G G9 0.28 0.0012220 RAB11FIP4 1743 315431 T G1 -0.33 0.0007109 CA10 1744 11869209 C P4 0.22 0.0054890 CA10 1745 4794315 G P4 -0.23 0.0012360 CA10 1746 1393735 G P4 -0.22 0.0019830 CA10 1747 1875675 T P4 0.25 0.0006519 CA10 1748 9893317 A P4 0.26 0.0005388 CA10 1749 11652641 G G4 -0.29 0.0041050 CA10 1749 11652641 G G12 -0.33 0.0048860 CA10 1749 11652641 G P4 -0.31 0.0008907 CA10 1750 12942636 T P6 -0.32 0.0022370 MSI2 1751 8066677 G G6 -0.28 0.0059210 MSI2 1751 8066677 G G7 -0.23 0.0054900 MSI2 1753 8077599 A N1 -0.30 0.0030850 SDK2 1754 1846334 A P3 -0.32 0.0055460 HRNBP3 1755 907898 C P6 0.44 0.0064750 HRNBP3 1756 4313839 C G3 0.29 0.0035960 OSBPL1A 1757 6508259 A G6 -0.35 0.0016990 OSBPL1A 1758 275857 C G16 0.61 0.0059070 OSBPL1A 1758 275857 C P4 0.48 0.0092890 OSBPL1A 1758 275857 C N4 0.71 0.0021820 OSBPL1A 1758 275857 C N7 0.56 0.0042880 CHST9 1760 17703962 G G3 0.37 0.0091660 CHST9 1761 9949654 C G9 0.40 0.0003672 DLGAP1 1763 9635857 G P1 0.40 0.0014780 DLGAP1 1763 9635857 G P3 0.45 0.0004842 DLGAP1 1764 7245298 G P3 0.43 0.0016550 ZFP161 1765 9965501 T G4 -0.76 0.0026240 NEDD4L 1773 11152073 A P3 0.36 0.0047540 CCBE1 1774 12969965 A P2 0.28 0.0099730 CCBE1 1775 4488565 C P5 -0.25 0.0064570 CDH7 1776 2658046 C G14 0.17 0.0052290 CDH7 1777 7241038 T G14 0.17 0.0060130 CDH7 1778 4455070 T G14 0.16 0.0081910 CDH7 1779 976882 A G14 0.16 0.0090970 CDH7 1780 7237421 T N3 0.27 0.0016680 CDH7 1780 7237421 T N5 0.27 0.0098740 CDH7 1781 8092259 G N3 0.27 0.0024310 CDH7 1783 1942832 A N3 0.26 0.0033240 CDH7 1784 1942831 G N3 0.26 0.0035760 CDH7 1785 8093720 A N3 0.25 0.0046980 CDH7 1786 1484725 T N3 0.25 0.0050040 CDH7 1786 1484725 T N2 0.28 0.0017760 CDH7 1787 1994230 T P6 0.53 0.0075190 CDH7 1788 8089669 A G4 0.23 0.0052220 CDH7 1789 12606480 C G4 0.21 0.0082640 CDH7 1790 1564815 C N3 0.54 0.0067680 DOK6 1791 12961718 C G7 0.23 0.0063950 DOK6 1793 4426448 G G9 0.30 0.0008687 DOK6 1793 4426448 G P2 0.29 0.0016190 DOK6 1793 4426448 G P5 0.23 0.0097090 DOK6 1794 12605879 G P1 0.30 0.0057610 DOK6 1794 12605879 G G9 0.28 0.0013060 DOK6 1794 12605879 G P2 0.27 0.0025790 MBP 1795 470181 G G12 0.30 0.0026850 MBP 1796 11660442 A G13 0.22 0.0072860 PTPRM 1798 8089695 C N1 0.62 0.0008150 PTPRM 1799 6506570 A G1 -0.27 0.0031230 PTPRM 1800 6506572 T G2 -0.25 0.0091560 PTPRM 1801 9949149 C G2 -0.24 0.0094030 KIAA0802 1802 4798677 A G1 0.25 0.0042410 KIAA0802 1803 12386117 A G6 -0.35 0.0094890 KIAA0802 1803 12386117 A G5 -0.25 0.0099120 KIAA0802 1804 7235093 A N3 0.54 0.0001818 KIAA0802 1804 7235093 A N1 0.64 0.0001433 LDLR 1806 2116897 T P6 0.31 0.0091270 LDLR 1807 1433099 A G14 -0.19 0.0080220 ZNF667 1808 7251105 G G14 -0.19 0.0042940 MACROD2 1809 6079395 G N5 0.27 0.0075940 MACROD2 1811 11697488 T P1 0.35 0.0027420 MACROD2 1812 809587 G N7 0.25 0.0079290 KIF16B 1813 6043875 C P6 -0.28 0.0061930 KIF16B 1813 6043875 C G2 -0.24 0.0076280 KIF16B 1813 6043875 C G1 -0.24 0.0066360 KIF16B 1813 6043875 C G16 -0.27 0.0041690 KIF16B 1813 6043875 C G3 -0.26 0.0086990 KIF16B 1813 6043875 C G6 -0.32 0.0009477 KIF16B 1814 6111022 T G16 0.28 0.0049120 KIF16B 1815 4814474 A G1 0.25 0.0064230 KIF16B 1815 4814474 A G16 0.24 0.0080570 KIF16B 1816 6034462 T P6 -0.29 0.0040210 KIF16B 1817 2328019 C G6 -0.25 0.0089580 KIF16B 1817 2328019 C P6 -0.26 0.0094690 KIF16B 1818 6135739 G P6 -0.29 0.0042470 KIF16B 1819 6111075 T G6 -0.26 0.0081000 KIF16B 1820 6111076 C P6 -0.27 0.0063350 KIF16B 1821 6034464 A G1 -0.24 0.0073690 KIF16B 1822 2876428 C G6 -0.25 0.0086240 KIF16B 1823 12624938 A G7 0.30 0.0046690 KIF16B 1824 2143988 A G7 0.23 0.0026840 KIF16B 1825 7352372 G G1 0.28 0.0090750 KIF16B 1826 6075069 T G1 0.42 0.0003007 KIF16B 1826 6075069 T G2 0.30 0.0079190 KIF16B 1826 6075069 T P2 -0.32 0.0072410 KIF16B 1826 6075069 T G3 0.41 0.0012840 KIF16B 1827 6080359 C N1 -0.36 0.0018350 MAPRE1 1828 410488 A G16 0.27 0.0029080 MAPRE1 1829 2070090 T G8 0.24 0.0020120 MAPRE1 1829 2070090 T G14 0.29 0.0007217 PTPRT 1830 4810349 T P5 0.24 0.0055900 PTPRT 1831 2013923 G P5 0.25 0.0060750 PTPRT 1833 746413 C P1 0.35 0.0013050 PTPRT 1833 746413 C N6 -0.28 0.0029880 PTPRT 1834 6065434 T N6 -0.27 0.0068540 PTPRT 1836 6065487 A P2 -0.27 0.0048940 PTPRT 1837 4810366 C G10 0.19 0.0043630 PTPRT 1838 2017914 G G7 0.22 0.0080940 PTPRT 1838 2017914 G G10 0.19 0.0041790 PTPRT 1839 6072869 G N5 0.33 0.0050000 PRNT 1840 6052824 A G1 0.27 0.0075650 KCNB1 1842 9636516 A P3 0.36 0.0025780 KCNB1 1843 496511 C G6 -0.28 0.0040330 KCNB1 1844 6095546 A G2 -0.29 0.0039110 KCNB1 1845 4647 T G2 -0.28 0.0058190 KCNB1 1845 4647 T P3 -0.33 0.0096390 CDH4 1848 6089265 T G2 -0.32 0.0021190 CDH4 1849 1891572 T N5 -0.28 0.0055020 CDH4 1850 17811544 G N5 -0.27 0.0059340 CDH4 1850 17811544 G P4 -0.19 0.0083060 CDH4 1851 6142884 A G15 -0.22 0.0061750 FERMT1 1852 6117072 C G12 -0.29 0.0021930 FERMT1 1853 6085406 A G4 -0.25 0.0019890 FERMT1 1854 10373 T G4 -0.24 0.0033280 PLCB1 1857 2235212 A P1 0.35 0.0057060 PLCB1 1858 6055678 T G16 0.33 0.0040720 C21ORF37 1861 12483129 C N2 0.26 0.0025100 C21ORF37 1861 12483129 C N6 0.27 0.0033900 NCAM2 1862 2826830 G G11 0.27 0.0059510 NCAM2 1862 2826830 G G4 0.28 0.0041390 NCAM2 1863 3787603 G G11 0.26 0.0079430 NCAM2 1864 1599228 C N3 0.30 0.0015950 ERG 1865 461592 C G9 -0.30 0.0030480 ERG 1865 461592 C N7 -0.27 0.0033130 ERG 1866 461488 G N7 -0.26 0.0036820 ERG 1867 2070527 A G9 -0.27 0.0062580 PCP4 1868 2837257 C G3 0.30 0.0064480 PCP4 1868 2837257 C G6 0.34 0.0016930 PCP4 1869 398802 G G15 0.24 0.0076060 SLC37A1 1870 412212 C N5 -0.34 0.0048170 SLC37A1 1872 381899 A N5 -0.32 0.0049270 SLC37A1 1872 381899 A N4 -0.28 0.0093920 ARVCF 1873 2239395 G P5 0.66 0.0098270 HPS4 1875 739289 C G9 0.40 0.0049610 ARFGAP3 1876 6002963 G G10 -0.18 0.0037870 ARFGAP3 1877 738536 A G6 0.33 0.0005261 ARFGAP3 1878 4822208 T G6 0.31 0.0007756 PACSIN2 1879 1076118 T G10 -0.18 0.0020710 PACSIN2 1880 738383 C G6 0.31 0.0010780 PACSIN2 1881 1071960 C N6 0.26 0.0072050 PACSIN2 1882 4140554 C G10 -0.17 0.0033560 PACSIN2 1883 7291153 C G10 -0.17 0.0052570 PACSIN2 1883 7291153 C G6 -0.28 0.0033790 PACSIN2 1884 1569507 G G10 -0.17 0.0056840 PACSIN2 1885 5751410 A G10 -0.16 0.0083500 PACSIN2 1886 713717 T G6 0.28 0.0033910 PACSIN2 1887 737782 G G6 0.27 0.0048780 PACSIN2 1889 738379 A G10 -0.16 0.0084240 TTLL1 1890 2076156 G G8 0.33 0.0041600 TTLL1 1891 135001 C P7 0.17 0.0063380 TTLL1 1892 135002 C P7 0.17 0.0072570 EFCAB6 1894 12628583 C G2 -0.37 0.0082480

TABLE-US-00005 TABLE A Summary of SNPs (NCBI Human Genome Reference Assembly Build 36.3) Seq ID Gene Chr Position (BP) Seq ID Gene Chr Position (BP) 1 KIF1B 1 10,279,993 2 KIF1B 1 10,320,154 3 KIF1B 1 10,323,189 4 KIF1B 1 10,343,505 5 SYT6 1 114,452,599 6 NGF 1 115,631,509 7 NGF 1 115,664,140 8 SLC22A15 1 116,328,295 9 SLC22A15 1 116,329,613 10 SLC22A15 1 116,353,502 11 SLC22A15 1 116,381,302 12 PTGFRN 1 117,269,213 13 PTGFRN 1 117,273,572 14 PTGFRN 1 117,284,884 15 PTGFRN 1 117,333,336 16 CGN 1 149,743,817 17 RP1-21O18.1 1 15,214,000 18 RP1-21O18.1 1 15,265,882 19 RP1-21O18.1 1 15,278,076 20 RP1-21O18.1 1 15,281,743 21 RP1-21O18.1 1 15,285,942 22 RP1-21O18.1 1 15,316,063 23 ATF6 1 160,062,520 24 ATF6 1 160,107,168 25 OLFML2B 1 160,230,414 26 OLFML2B 1 160,234,305 27 OLFML2B 1 160,247,126 28 FAM78B 1 164,309,282 29 FAM78B 1 164,314,302 30 SEC16B 1 176,215,337 31 RALGPS2 1 176,976,589 32 RALGPS2 1 177,051,615 33 KCNK2 1 213,266,926 34 KCNK2 1 213,387,083 35 KCNK2 1 213,405,370 36 KCNK2 1 213,405,685 37 KCNK2 1 213,412,561 38 KCNK2 1 213,426,881 39 KCNK2 1 213,474,680 40 USH2A 1 213,526,280 41 USH2A 1 213,537,370 42 USH2A 1 213,911,770 43 USH2A 1 213,954,742 44 USH2A 1 213,955,280 45 USH2A 1 214,404,070 46 USH2A 1 214,404,156 47 USH2A 1 214,498,585 48 USH2A 1 214,506,786 49 USH2A 1 214,572,091 50 ESRRG 1 214,788,713 51 ESRRG 1 214,789,473 52 ESRRG 1 214,827,730 53 ESRRG 1 214,836,783 54 ESRRG 1 214,855,550 55 ESRRG 1 214,861,049 56 ESRRG 1 214,950,266 57 EPHB2 1 22,984,956 58 EPHB2 1 23,091,301 59 SLC35F3 1 232,525,097 60 RYR2 1 235,413,480 61 RYR2 1 235,435,907 62 RYR2 1 235,500,248 63 RYR2 1 235,513,475 64 RYR2 1 235,569,612 65 RYR2 1 235,661,657 66 RYR2 1 235,795,490 67 RYR2 1 235,805,642 68 RYR2 1 236,056,960 69 CHRM3 1 237,894,973 70 CHRM3 1 237,911,900 71 CHRM3 1 237,937,398 72 CHRM3 1 237,944,344 73 CHRM3 1 237,958,134 74 CHRM3 1 237,969,464 75 CHRM3 1 237,996,528 76 FMN2 1 238,349,704 77 FMN2 1 238,353,478 78 FMN2 1 238,416,539 79 FMN2 1 238,426,833 80 FMN2 1 238,455,099 81 FMN2 1 238,486,712 82 FMN2 1 238,494,888 83 FMN2 1 238,512,719 84 FMN2 1 238,525,003 85 FMN2 1 238,669,725 86 FMN2 1 238,670,023 87 RGS7 1 239,588,948 88 PLD5 1 240,632,975 89 CLIC4 1 24,963,033 90 CLIC4 1 24,970,832 91 AGBL4-C1ORF165 1 48,833,568 92 AGBL4-C1ORF165 1 49,006,963 93 AGBL4-C1ORF165 1 49,124,764 94 AGBL4-C1ORF165 1 49,125,312 95 AGBL4-C1ORF165 1 49,133,207 96 AGBL4-C1ORF165 1 49,239,649 97 AGBL4-C1ORF165 1 49,243,353 98 SCP2 1 53,287,104 99 LRP8 1 53,561,462 100 ELTD1 1 79,259,313 101 ELTD1 1 79,260,672 102 PRKACB 1 84,299,506 103 PRKACB 1 84,301,022 104 PRKACB 1 84,450,848 105 HPCAL1 2 10,301,740 106 KCNF1 2 10,981,799 107 KCNF1 2 10,999,213 108 NTSR2 2 11,726,315 109 NAP5 2 133,607,512 110 NAP5 2 133,642,409 111 RAB3GAP1 2 135,514,217 112 RAB3GAP1 2 135,541,544 113 RAB3GAP1 2 135,649,190 114 ZRANB3 2 135,868,244 115 ZRANB3 2 135,981,101 116 NXPH2 2 139,154,184 117 LRP1B 2 140,708,533 118 LRP1B 2 140,730,389 119 LRP1B 2 140,740,113 120 LRP1B 2 140,749,675 121 LRP1B 2 140,986,740 122 LRP1B 2 141,715,030 123 LRP1B 2 141,896,198 124 LRP1B 2 142,066,600 125 LRP1B 2 142,278,834 126 LRP1B 2 142,283,237 127 LRP1B 2 142,284,380 128 LRP1B 2 142,293,931 129 KYNU 2 143,368,826 130 KYNU 2 143,405,309 131 KYNU 2 143,430,832 132 KYNU 2 143,455,211 133 KYNU 2 143,598,044 134 ARHGAP15 2 143,651,019 135 ARHGAP15 2 143,685,981 136 ARHGAP15 2 143,769,771 137 ARHGAP15 2 143,884,507 138 ARHGAP15 2 143,903,015 139 ARHGAP15 2 143,961,757 140 ARHGAP15 2 144,294,622 141 ARHGAP15 2 144,295,364 142 KIF5C 2 149,333,649 143 KIF5C 2 149,600,091 144 FMNL2 2 152,981,465 145 FMNL2 2 153,122,655 146 FMNL2 2 153,166,996 147 FMNL2 2 153,201,156 148 FMNL2 2 153,207,856 149 KCNJ3 2 155,324,938 150 KCNJ3 2 155,326,572 151 KCNJ3 2 155,411,014 152 PKP4 2 159,148,211 153 PKP4 2 159,155,564 154 PKP4 2 159,163,035 155 PKP4 2 159,168,396 156 PKP4 2 159,172,437 157 PKP4 2 159,204,636 158 PKP4 2 159,219,409 159 PKP4 2 159,232,049 160 PLA2R1 2 160,519,430 161 PLA2R1 2 160,543,237 162 PLA2R1 2 160,575,799 163 PLA2R1 2 160,616,115 164 KCNH7 2 163,221,260 165 SCN3A 2 165,732,374 166 SCN1A 2 166,606,495 167 SCN1A 2 166,629,033 168 SCN1A 2 166,650,019 169 SCN9A 2 166,781,097 170 SCN9A 2 166,784,624 171 SCN9A 2 166,807,404 172 SCN9A 2 166,817,960 173 SCN9A 2 166,871,909 174 SCN9A 2 166,874,107 175 SCN7A 2 166,989,998 176 CERKL 2 182,239,099 177 PDE1A 2 182,752,922 178 PDE1A 2 182,763,240 179 PDE1A 2 182,767,445 180 PDE1A 2 182,804,991 181 PDE1A 2 182,821,396 182 PDE1A 2 182,833,270 183 PDE1A 2 182,871,393 184 PDE1A 2 182,886,451 185 PDE1A 2 182,910,657 186 PDE1A 2 182,918,516 187 PDE1A 2 182,932,372 188 PDE1A 2 182,971,998 189 PDE1A 2 183,029,113 190 PDE1A 2 183,067,065 191 ALS2 2 202,315,109 192 ALS2 2 202,354,735 193 PARD3B 2 205,291,115 194 PARD3B 2 205,326,956 195 PARD3B 2 205,347,353 196 PARD3B 2 205,858,397 197 PARD3B 2 205,866,562 198 PARD3B 2 205,906,564 199 PARD3B 2 205,932,117 200 PARD3B 2 205,955,695 201 PARD3B 2 205,967,382 202 PARD3B 2 206,172,710 203 NRP2 2 206,426,955 204 NRP2 2 206,441,948 205 NRP2 2 206,443,765 206 PIP5K3 2 208,948,035 207 PIP5K3 2 208,956,492 208 ERBB4 2 211,933,765 209 ERBB4 2 211,975,964 210 ERBB4 2 212,022,377 211 CUL3 2 225,109,321 212 IRS1 2 227,388,355 213 COL4A4 2 227,619,969 214 COL4A4 2 227,630,259 215 COL4A3 2 227,795,722 216 DNER 2 229,972,935 217 DNER 2 230,024,102 218 ECEL1 2 233,048,959 219 CHRNG 2 233,127,640 220 SAG 2 233,900,559 221 SAG 2 233,902,504 222 KLHL29 2 23,504,556 223 KLHL29 2 23,504,709 224 KLHL29 2 23,504,805 225 KLHL29 2 23,507,416 226 KLHL29 2 23,519,201 227 KLHL29 2 23,782,141 228 KCNK3 2 26,798,797 229 KCNK3 2 26,807,044 230 DPYSL5 2 26,957,635 231 DPYSL5 2 26,986,326 232 DPYSL5 2 27,023,044 233 BRE 2 28,212,255 234 BRE 2 28,243,350 235 BRE 2 28,373,587 236 BRE 2 28,396,438 237 CRIM1 2 36,443,527 238 CRIM1 2 36,471,032 239 CRIM1 2 36,477,691 240 CRIM1 2 36,510,809 241 CRIM1 2 36,523,515 242 CRIM1 2 36,535,123 243 CRIM1 2 36,549,124 244 CRIM1 2 36,581,523 245 CRIM1 2 36,581,946 246 SLC8A1 2 40,230,588 247 SLC8A1 2 40,241,861 248 SLC8A1 2 40,253,816 249 SLC8A1 2 40,267,644 250 SLC8A1 2 40,524,155 251 SLC8A1 2 40,524,198 252 HAAO 2 42,918,059 253 PLEKHH2 2 43,822,986 254 PLEKHH2 2 43,823,791 255 PLEKHH2 2 43,839,444 256 PLEKHH2 2 43,846,952 257 C2ORF34 2 44,446,479 258 C2ORF34 2 44,457,570 259 C2ORF34 2 44,474,546 260 C2ORF34 2 44,500,542 261 C2ORF34 2 44,501,551 262 C2ORF34 2 44,508,409 263 C2ORF34 2 44,514,120 264 C2ORF34 2 44,529,730 265 C2ORF34 2 44,536,723 266 C2ORF34 2 44,574,451 267 C2ORF34 2 44,584,000 268 C2ORF34 2 44,621,606 269 C2ORF34 2 44,631,967 270 C2ORF34 2 44,641,482 271 C2ORF34 2 44,645,163 272 C2ORF34 2 44,686,360 273 C2ORF34 2 44,715,296 274 C2ORF34 2 44,834,212 275 C2ORF34 2 44,834,623 276 PRKCE 2 45,737,717 277 PRKCE 2 46,130,026 278 PRKCE 2 46,226,779 279 EPAS1 2 46,401,568 280 FBXO11 2 47,952,212 281 FBXO11 2 47,978,008 282 PSME4 2 53,957,822 283 PSME4 2 54,001,835 284 PSME4 2 54,018,352 285 PSME4 2 54,055,952 286 PSME4 2 54,064,285 287 ACYP2 2 54,189,467 288 ACYP2 2 54,329,389 289 ACYP2 2 54,329,418 290 ACYP2 2 54,350,261 291 CCDC85A 2 56,266,849 292 CCDC85A 2 56,312,732 293 CCDC85A 2 56,344,184 294 CCDC85A 2 56,416,774 295 CCDC85A 2 56,493,023 296 OTX1 2 63,151,654 297 AAK1 2 69,639,692 298 AAK1 2 69,768,980 299 AAK1 2 69,834,530 300 CTNNA2 2 79,631,620 301 CTNNA2 2 79,635,253 302 CTNNA2 2 79,644,485 303 CTNNA2 2 79,648,869 304 CTNNA2 2 79,728,810 305 CTNNA2 2 80,246,403 306 CTNNA2 2 80,346,411 307 CTNNA2 2 80,348,223 308 CTNNA2 2 80,493,928 309 CTNNA2 2 80,498,999 310 CTNNA2 2 80,652,425 311 CTNNA2 2 80,657,667 312 CTNNA2 2 80,663,934 313 C2ORF46 2 8,262,682 314 C2ORF46 2 8,361,310 315 C2ORF46 2 8,384,366 316 DDEF2 2 9,458,300 317 INPP4A 2 98,437,334 318 INPP4A 2 98,502,170 319 ATP2B2 3 10,358,996 320 PLCXD2 3 112,883,336 321 PLCXD2 3 112,941,527 322 PLCXD2 3 112,944,650 323 PLCXD2 3 112,961,319 324 PLCXD2 3 112,964,847 325 CDGAP 3 120,527,813 326 STXBP5L 3 122,476,483 327 KALRN 3 125,928,594 328 CNTN6 3 1,268,504 329 CNTN6 3 1,292,727 330 CPNE4 3 132,865,247 331 CPNE4 3 132,865,495 332 CPNE4 3 132,885,425 333 CPNE4 3 132,886,287 334 CPNE4 3 132,889,696 335 CPNE4 3 132,890,801 336 CPNE4 3 132,907,690 337 CPNE4 3 133,142,633 338 CPNE4 3 133,145,979 339 CNTN6 3 1,336,323 340 RAB6B 3 135,041,388 341 CNTN6 3 1,350,581 342 CNTN6 3 1,357,151 343 CNTN6 3 1,357,358 344 EPHB1 3 136,133,973 345 EPHB1 3 136,152,557 346 EPHB1 3 136,153,214 347 EPHB1 3 136,154,213 348 EPHB1 3 136,154,975 349 EPHB1 3 136,156,084 350 EPHB1 3 136,158,491 351 EPHB1 3 136,165,323 352 EPHB1 3 136,172,644 353 CNTN6 3 1,375,419 354 CNTN6 3 1,399,850 355 CLSTN2 3 141,648,210 356 CLSTN2 3 141,660,969 357 CLSTN2 3 141,661,175 358 CLSTN2 3 141,662,920 359 CLSTN2 3 141,663,200 360 CLSTN2 3 141,764,774 361 CLSTN2 3 141,774,103 362 CLSTN2 3 141,775,226 363 SPSB4 3 142,258,988 364 SPSB4 3 142,287,637 365 SLC6A6 3 14,421,894 366 DAZL 3 16,611,406 367 DAZL 3 16,611,469 368 DAZL 3 16,627,901 369 SERPINI1 3 169,041,318 370 SERPINI1 3 169,077,645 371 SLC7A14 3 171,678,031 372 SLC7A14 3 171,682,206 373 PLD1 3 172,791,538 374 PLD1 3 172,887,172 375 PLD1 3 172,897,589 376 PLD1 3 172,954,990 377 PLD1 3 172,963,579 378 PLD1 3 172,989,645 379 PLD1 3 172,991,671 380 NLGN1 3 175,384,416 381 NLGN1 3 175,458,980 382 NLGN1 3 175,493,649 383 NLGN1 3 175,515,979 384 NLGN1 3 175,541,245 385 HTR3D 3 185,232,425 386 HTR3D 3 185,236,739 387 HTR3E 3 185,313,087 388 LEPREL1 3 191,236,401 389 LEPREL1 3 191,237,107 390 LEPREL1 3 191,261,577 391 LEPREL1 3 191,280,803 392 LEPREL1 3 191,356,831 393 IL1RAP 3 191,892,719 394 IL1RAP 3 191,914,687 395 LRRC15 3 195,586,726 396 CENTB2 3 196,483,019 397 CENTB2 3 196,647,738 398 UBXD7 3 197,608,675 399 CNTN4 3 2,375,967 400 RARB 3 25,544,885 401 RARB 3 25,589,536 402 RARB 3 25,592,407 403 RARB 3 25,593,163 404 CNTN4 3 2,734,283 405 CNTN4 3 3,035,913 406 CNTN4 3 3,073,041 407 CLASP2 3 33,516,308 408 CLASP2 3 33,516,362 409 CLASP2 3 33,537,118 410 CLASP2 3 33,668,798 411 CLASP2 3 33,726,022 412 ARPP-21 3 35,760,612 413 STAC 3 36,407,617 414 ULK4 3 41,482,456 415 ULK4 3 41,507,554 416 ULK4 3 41,563,607 417 ULK4 3 41,564,968 418 ULK4 3 41,574,775 419 ULK4 3 41,575,331 420 ULK4 3 41,971,140 421 ITPR1 3 4,729,125 422 ITPR1 3 4,846,598 423 SEMA3F 3 50,180,966 424 SEMA3F 3 50,182,079 425 SEMA3F 3 50,199,229 426 CACNA2D2 3 50,451,382 427 CACNA2D3 3 54,127,859 428 CACNA2D3 3 54,331,793 429 ERC2 3 55,743,028 430 ERC2 3 55,757,809 431 ERC2 3 55,760,546 432 ERC2 3 55,828,309 433 ERC2 3 55,877,492 434 ERC2 3 55,902,605 435 ERC2 3 56,116,883 436 ERC2 3 56,119,301 437 ERC2 3 56,164,173 438 ERC2 3 56,298,486 439 ERC2 3 56,318,391 440 ERC2 3 56,347,766 441 ERC2 3 56,348,984 442 ERC2 3 56,360,378 443 ERC2 3 56,368,109 444 ERC2 3 56,393,831 445 ERC2 3 56,410,435 446 ERC2 3 56,414,093 447 ERC2 3 56,422,909 448 ERC2 3 56,433,200 449 ERC2 3 56,462,620 450 ERC2 3 56,464,816 451 ERC2 3 56,491,685 452 ERC2 3 56,496,204 453 ERC2 3 56,496,259 454 FHIT 3 59,814,275 455 FHIT 3 59,824,587 456 FHIT 3 60,462,353 457 FHIT 3 61,135,266 458 FHIT 3 61,137,444 459 PTPRG 3 61,709,002 460 PTPRG 3 61,709,579 461 PTPRG 3 61,723,402 462 PTPRG 3 61,753,808 463 PTPRG 3 62,036,852 464 PTPRG 3 62,219,484 465 PTPRG 3 62,219,610 466 PTPRG 3 62,256,476 467 CADPS 3 62,480,839 468 CADPS 3 62,487,886 469 CADPS 3 62,498,262 470 CADPS 3 62,503,301 471 CADPS 3 62,716,081 472 CADPS 3 62,748,900 473 CADPS 3 62,748,989 474 CADPS 3 62,777,879 475 CADPS 3 62,786,626 476 CADPS 3 62,789,812 477 CADPS 3 62,801,974 478 SYNPR 3 63,493,103 479 PRICKLE2 3 64,091,416 480 PRICKLE2 3 64,176,516 481 MAGI1 3 65,330,646 482 MAGI1 3 65,337,837 483 MAGI1 3 65,476,046 484 MAGI1 3 65,576,717 485 FAM19A1 3 68,409,920 486 FAM19A1 3 68,470,682 487 FOXP1 3 70,972,978 488 FOXP1 3 71,021,299 489 FOXP1 3 71,295,488 490 GBE1 3 81,633,005

491 GBE1 3 81,643,783 492 GBE1 3 81,669,129 493 GBE1 3 81,687,469 494 GBE1 3 81,687,869 495 GBE1 3 81,694,225 496 GBE1 3 81,816,787 497 GBE1 3 81,859,450 498 GBE1 3 81,888,207 499 GBE1 3 81,894,474 500 HTR1F 3 88,105,976 501 EPHA6 3 97,967,793 502 EPHA6 3 98,268,377 503 EPHA6 3 98,270,901 504 DKK2 4 108,073,445 505 DKK2 4 108,257,617 506 PAPSS1 4 108,875,283 507 COL25A1 4 109,954,162 508 COL25A1 4 110,179,691 509 COL25A1 4 110,189,985 510 COL25A1 4 110,198,274 511 COL25A1 4 110,198,580 512 ANK2 4 114,298,380 513 ANK2 4 114,298,464 514 ANK2 4 114,298,576 515 ANK2 4 114,399,491 516 ANK2 4 114,424,380 517 ANK2 4 114,436,352 518 ANK2 4 114,445,280 519 CAMK2D 4 114,723,041 520 CAMK2D 4 114,723,767 521 NDST3 4 119,197,389 522 NDST3 4 119,312,058 523 PRSS12 4 119,462,492 524 GPR103 4 122,518,528 525 MAML3 4 140,868,325 526 MAML3 4 140,870,180 527 IL15 4 142,929,173 528 INPP4B 4 143,195,583 529 INPP4B 4 143,201,848 530 INPP4B 4 143,221,023 531 INPP4B 4 143,222,465 532 INPP4B 4 143,223,756 533 INPP4B 4 143,262,085 534 INPP4B 4 143,264,932 535 INPP4B 4 143,269,935 536 INPP4B 4 143,405,941 537 INPP4B 4 143,476,047 538 POU4F2 4 147,768,753 539 LDB2 4 16,200,696 540 LDB2 4 16,208,501 541 FSTL5 4 162,696,532 542 FSTL5 4 162,744,370 543 FSTL5 4 162,828,621 544 FSTL5 4 162,852,707 545 FSTL5 4 163,022,990 546 FSTL5 4 163,038,911 547 FSTL5 4 163,171,406 548 FSTL5 4 163,275,058 549 FSTL5 4 163,281,294 550 FSTL5 4 163,316,581 551 FSTL5 4 163,369,235 552 LDB2 4 16,363,986 553 LDB2 4 16,365,914 554 LDB2 4 16,513,031 555 LDB2 4 16,515,486 556 LDB2 4 16,525,999 557 TLL1 4 167,073,589 558 PALLD 4 169,684,483 559 PALLD 4 169,690,892 560 PALLD 4 169,693,682 561 PALLD 4 169,702,565 562 PALLD 4 169,713,776 563 PALLD 4 169,721,943 564 PALLD 4 169,831,259 565 PALLD 4 169,831,979 566 PALLD 4 169,854,703 567 PALLD 4 169,855,143 568 PALLD 4 169,866,028 569 PALLD 4 169,971,032 570 ODZ3 4 183,473,721 571 ODZ3 4 183,476,755 572 ODZ3 4 183,478,510 573 ODZ3 4 183,917,862 574 ENPP6 4 185,269,255 575 ENPP6 4 185,283,835 576 ENPP6 4 185,287,394 577 ENPP6 4 185,287,415 578 ENPP6 4 185,300,448 579 ENPP6 4 185,314,095 580 CASP3 4 185,783,023 581 CASP3 4 185,791,294 582 SLIT2 4 19,872,156 583 SLIT2 4 20,162,402 584 SLIT2 4 20,172,206 585 SLIT2 4 20,177,664 586 SLIT2 4 20,194,981 587 SLIT2 4 20,202,844 588 PCDH7 4 30,441,417 589 KIAA1239 4 36,916,631 590 KIAA1239 4 37,005,415 591 KIAA1239 4 37,133,996 592 KIAA1239 4 37,134,494 593 KIAA1239 4 37,157,082 594 TBC1D1 4 37,815,251 595 UBE2K 4 39,386,342 596 UBE2K 4 39,464,805 597 UBE2K 4 39,494,511 598 LIMCH1 4 41,194,791 599 LIMCH1 4 41,213,350 600 LIMCH1 4 41,213,408 601 LIMCH1 4 41,215,951 602 LIMCH1 4 41,221,506 603 LIMCH1 4 41,221,779 604 LIMCH1 4 41,223,320 605 LIMCH1 4 41,308,688 606 LIMCH1 4 41,351,387 607 LIMCH1 4 41,354,243 608 LIMCH1 4 41,429,386 609 LOC389207 4 42,634,794 610 NPFFR2 4 73,115,321 611 NPFFR2 4 73,119,485 612 NPFFR2 4 73,122,182 613 NPFFR2 4 73,163,818 614 NPFFR2 4 73,236,822 615 NPFFR2 4 73,291,379 616 SCARB2 4 77,296,499 617 SHROOM3 4 77,855,667 618 SHROOM3 4 77,879,755 619 SCD5 4 83,785,141 620 SCD5 4 83,788,761 621 SCD5 4 83,794,856 622 SCD5 4 83,794,931 623 SCD5 4 83,845,049 624 HERC3 4 89,741,644 625 FAM13A1 4 89,915,913 626 FAM13A1 4 89,950,302 627 FAM13A1 4 89,950,932 628 SLC2A9 4 9,423,554 629 PDLIM5 4 95,558,356 630 SLC2A9 4 9,565,177 631 PDLIM5 4 95,660,615 632 PDLIM5 4 95,701,398 633 PDLIM5 4 95,701,843 634 PDLIM5 4 95,706,737 635 PDLIM5 4 95,747,196 636 PDLIM5 4 95,793,146 637 SLC2A9 4 9,605,988 638 SLC2A9 4 9,606,401 639 SLC2A9 4 9,606,899 640 SLC2A9 4 9,616,373 641 SLC2A9 4 9,633,401 642 SLC2A9 4 9,636,640 643 SLC2A9 4 9,665,474 644 FBXL17 5 107,441,485 645 FBXL17 5 107,546,460 646 FBXL17 5 107,612,678 647 FBXL17 5 107,624,474 648 FBXL17 5 107,704,154 649 FBXL17 5 107,773,275 650 FBXL17 5 107,810,930 651 FBXL17 5 107,812,906 652 PJA2 5 108,787,364 653 PJA2 5 108,817,419 654 KCNN2 5 113,739,288 655 KCNN2 5 113,751,518 656 KCNN2 5 113,763,996 657 KCNN2 5 113,784,704 658 KCNN2 5 113,790,709 659 KCNN2 5 113,858,701 660 SEMA6A 5 115,914,844 661 HSD17B4 5 118,817,237 662 HSD17B4 5 118,927,674 663 SNCAIP 5 121,678,639 664 SNCAIP 5 121,699,768 665 SNCAIP 5 121,757,816 666 SNCAIP 5 121,768,808 667 SNCAIP 5 121,796,570 668 SNX2 5 122,116,630 669 SNX2 5 122,174,518 670 SNX2 5 122,194,062 671 SNX2 5 122,201,930 672 SNX24 5 122,255,495 673 SNX24 5 122,273,273 674 SNX24 5 122,283,900 675 SNX24 5 122,363,934 676 ADAMTS19 5 129,005,631 677 VDAC1 5 133,405,061 678 TRPC7 5 135,649,997 679 TRPC7 5 135,695,682 680 TRPC7 5 135,705,746 681 TRPC7 5 135,712,132 682 TRPC7 5 135,724,949 683 DNAH5 5 13,795,858 684 DNAH5 5 13,822,974 685 DNAH5 5 13,832,743 686 DNAH5 5 13,841,886 687 DNAH5 5 13,842,420 688 DNAH5 5 13,947,894 689 DNAH5 5 13,953,345 690 DNAH5 5 13,955,220 691 DNAH5 5 13,957,400 692 DNAH5 5 14,034,968 693 GRIA1 5 152,893,595 694 GRIA1 5 152,916,373 695 GRIA1 5 152,931,785 696 GRIA1 5 152,952,893 697 GRIA1 5 152,956,518 698 GRIA1 5 153,075,197 699 GRIA1 5 153,100,457 700 GRIA1 5 153,112,499 701 GRIA1 5 153,127,393 702 GRIA1 5 153,150,567 703 GRIA1 5 153,159,007 704 ODZ2 5 167,085,900 705 MYO10 5 16,711,495 706 MYO10 5 16,711,524 707 ODZ2 5 167,162,881 708 ODZ2 5 167,191,250 709 ODZ2 5 167,391,524 710 ODZ2 5 167,556,686 711 ODZ2 5 167,610,277 712 ODZ2 5 167,634,619 713 MYO10 5 16,822,273 714 MYO10 5 16,838,077 715 BASP1 5 17,266,319 716 PLEKHG4B 5 208,367 717 PLEKHG4B 5 208,629 718 PLEKHG4B 5 208,831 719 PLEKHG4B 5 210,750 720 PLEKHG4B 5 226,200 721 CDH10 5 24,500,153 722 CDH10 5 24,533,855 723 SLC45A2 5 34,019,127 724 SLC45A2 5 34,025,275 725 C1QTNF3 5 34,071,366 726 C1QTNF3 5 34,074,611 727 C1QTNF3 5 34,083,721 728 C1QTNF3 5 34,087,314 729 SLC1A3 5 36,738,812 730 EGFLAM 5 38,269,319 731 EGFLAM 5 38,296,060 732 EGFLAM 5 38,320,906 733 AHRR 5 431,413 734 AHRR 5 465,694 735 AHRR 5 508,696 736 EXOC3 5 517,153 737 ITGA1 5 52,155,113 738 ITGA1 5 52,265,502 739 ITGA1 5 52,285,233 740 ITGA2 5 52,402,662 741 ITGA2 5 52,425,212 742 PDE4D 5 58,432,005 743 PDE4D 5 58,744,184 744 ELOVL7 5 60,101,698 745 ELOVL7 5 60,132,254 746 ELOVL7 5 60,152,637 747 ELOVL7 5 60,171,719 748 ELOVL7 5 60,201,944 749 TNPO1 5 72,174,208 750 TNPO1 5 72,182,236 751 TNPO1 5 72,217,160 752 FCHO2 5 72,384,028 753 CMYA5 5 79,029,508 754 CMYA5 5 79,058,467 755 CMYA5 5 79,070,418 756 THBS4 5 79,375,707 757 THBS4 5 79,376,918 758 THBS4 5 79,397,021 759 VCAN 5 82,818,286 760 VCAN 5 82,870,055 761 MEF2C 5 88,161,609 762 MEF2C 5 88,219,759 763 GPR98 5 89,976,245 764 GPR98 5 90,052,627 765 GPR98 5 90,109,033 766 GPR98 5 90,187,345 767 GPR98 5 90,203,767 768 SEMA5A 5 9,066,544 769 SEMA5A 5 9,107,741 770 SEMA5A 5 9,474,794 771 SEMA5A 5 9,477,130 772 SEMA5A 5 9,487,606 773 SEMA5A 5 9,495,994 774 CAST 5 96,088,713 775 SLC22A16 6 110,857,358 776 SLC22A16 6 110,914,475 777 HS3ST5 6 114,509,285 778 TRDN 6 123,728,987 779 TRDN 6 123,738,465 780 TRDN 6 123,743,637 781 TRDN 6 123,749,431 782 TRDN 6 123,753,816 783 TRDN 6 123,766,181 784 TRDN 6 123,791,627 785 TRDN 6 123,871,263 786 TRDN 6 123,877,575 787 TRDN 6 123,903,977 788 TRDN 6 123,931,045 789 TRDN 6 124,006,657 790 TRDN 6 124,017,012 791 NKAIN2 6 124,481,807 792 NKAIN2 6 124,747,202 793 NKAIN2 6 124,828,559 794 NKAIN2 6 124,867,074 795 NKAIN2 6 124,953,233 796 NKAIN2 6 124,962,839 797 NKAIN2 6 124,982,795 798 NKAIN2 6 124,986,819 799 NKAIN2 6 124,987,301 800 NKAIN2 6 125,020,491 801 PHACTR1 6 12,858,919 802 PHACTR1 6 13,276,521 803 PHACTR1 6 13,286,048 804 PHACTR1 6 13,297,254 805 EYA4 6 133,636,045 806 EYA4 6 133,643,088 807 EYA4 6 133,651,991 808 EYA4 6 133,668,941 809 PDE7B 6 136,218,421 810 PDE7B 6 136,244,527 811 PDE7B 6 136,375,641 812 PLAGL1 6 144,319,261 813 PLAGL1 6 144,354,821 814 PLAGL1 6 144,355,380 815 UTRN 6 144,651,202 816 UTRN 6 144,657,997 817 UTRN 6 145,021,020 818 SYNE1 6 152,505,595 819 SYNE1 6 152,511,829 820 JARID2 6 15,608,978 821 SLC22A3 6 160,771,756 822 PARK2 6 161,938,126 823 PARK2 6 161,960,395 824 PARK2 6 162,001,753 825 PARK2 6 162,026,087 826 PARK2 6 162,201,362 827 PARK2 6 162,204,134 828 PARK2 6 162,725,125 829 PARK2 6 162,877,565 830 PARK2 6 162,891,538 831 PARK2 6 162,899,137 832 PARK2 6 162,914,629 833 PARK2 6 162,959,624 834 PACRG 6 163,515,155 835 PACRG 6 163,523,252 836 PDE10A 6 165,674,966 837 PDE10A 6 165,835,911 838 PDE10A 6 165,868,541 839 ATXN1 6 16,595,385 840 ATXN1 6 16,762,002 841 ATXN1 6 16,767,074 842 ATXN1 6 16,799,821 843 SLC17A4 6 25,852,810 844 SLC17A4 6 25,887,371 845 SLC17A1 6 25,909,950 846 SLC17A4 6 25,917,888 847 SLC17A1 6 25,950,182 848 SLC17A3 6 25,972,877 849 SLC17A2 6 26,042,503 850 BTN3A1 6 26,506,534 851 BTN3A1 6 26,513,969 852 BTN3A1 6 26,525,105 853 BTN3A1 6 26,528,031 854 BTN2A3 6 26,534,466 855 BTN3A3 6 26,553,839 856 BTNL2 6 32,462,406 857 BTNL2 6 32,463,841 858 BTNL2 6 32,471,794 859 SLC22A23 6 3,395,265 860 LRFN2 6 40,526,934 861 LRFN2 6 40,535,717 862 LRFN2 6 40,585,166 863 LRFN2 6 40,598,884 864 PPP2R5D 6 43,095,976 865 KLC4 6 43,139,233 866 ELOVL5 6 53,298,209 867 ELOVL5 6 53,350,763 868 ELOVL5 6 53,372,444 869 RIMS1 6 72,772,376 870 RIMS1 6 72,784,876 871 RIMS1 6 72,860,627 872 RIMS1 6 72,866,707 873 RIMS1 6 72,939,135 874 RIMS1 6 72,963,198 875 RIMS1 6 72,974,869 876 RIMS1 6 72,977,664 877 RIMS1 6 72,982,413 878 RIMS1 6 73,031,069 879 HTR1B 6 78,228,979 880 KLHL32 6 97,480,306 881 KLHL32 6 97,589,639 882 KLHL32 6 97,595,870 883 KLHL32 6 97,673,659 884 CUX1 7 100,785,884 885 CUX1 7 101,306,594 886 CUX1 7 101,694,544 887 CADPS2 7 122,055,480 888 CADPS2 7 122,066,038 889 CADPS2 7 122,074,175 890 CADPS2 7 122,090,557 891 CADPS2 7 122,093,518 892 CADPS2 7 122,329,881 893 GRM8 7 125,808,541 894 GRM8 7 125,837,771 895 GRM8 7 125,879,584 896 GRM8 7 125,888,427 897 GRM8 7 125,912,289 898 GRM8 7 126,156,034 899 GRM8 7 126,225,935 900 GRM8 7 126,234,800 901 GRM8 7 126,299,256 902 GRM8 7 126,521,407 903 GRM8 7 126,552,824 904 GRM8 7 126,699,931 905 EXOC4 7 132,456,559 906 EXOC4 7 132,754,129 907 EXOC4 7 132,789,020 908 EXOC4 7 132,895,544 909 EXOC4 7 132,917,865 910 EXOC4 7 132,938,673 911 EXOC4 7 133,236,629 912 EXOC4 7 133,265,250 913 EXOC4 7 133,352,637 914 EXOC4 7 133,378,037 915 DGKI 7 136,730,489 916 DGKI 7 136,735,790 917 CREB3L2 7 137,269,815 918 CREB3L2 7 137,275,099 919 CREB3L2 7 137,278,186 920 TBXAS1 7 139,135,304 921 TBXAS1 7 139,175,131 922 TBXAS1 7 139,184,991 923 TBXAS1 7 139,311,144 924 ETV1 7 13,945,334 925 CNTNAP2 7 145,430,948 926 CNTNAP2 7 145,431,076 927 CNTNAP2 7 145,688,576 928 CNTNAP2 7 145,710,838 929 CNTNAP2 7 145,724,542 930 CNTNAP2 7 145,906,353 931 CNTNAP2 7 146,782,515 932 CNTNAP2 7 146,786,412 933 CNTNAP2 7 146,788,354 934 CNTNAP2 7 146,800,067 935 CNTNAP2 7 147,069,599 936 CNTNAP2 7 147,102,055 937 CNTNAP2 7 147,136,686 938 CNTNAP2 7 147,669,284 939 CNTNAP2 7 147,712,266 940 PTPRN2 7 157,024,663 941 PTPRN2 7 157,175,770 942 PTPRN2 7 157,662,662 943 PTPRN2 7 157,973,350 944 STK31 7 23,760,407 945 STK31 7 23,799,768 946 SKAP2 7 26,795,178 947 SKAP2 7 26,827,158 948 SKAP2 7 26,827,213 949 SKAP2 7 26,830,698 950 SKAP2 7 26,858,965 951 CREB5 7 28,286,559 952 CREB5 7 28,798,822 953 CREB5 7 28,812,569 954 CREB5 7 28,818,987 955 CREB5 7 28,870,041 956 CREB5 7 28,906,935 957 CARD11 7 2,928,819 958 CHN2 7 29,483,175 959 CHN2 7 29,486,454 960 CHN2 7 29,560,895 961 SCRN1 7 29,926,987 962 SCRN1 7 29,929,459 963 SCRN1 7 30,052,432 964 ZNRF2 7 30,379,551 965 CRHR2 7 30,676,000 966 CRHR2 7 30,775,386 967 FLJ22374 7 30,787,631 968 FLJ22374 7 30,803,801 969 FLJ22374 7 30,813,272 970 FLJ22374 7 30,832,290 971 FLJ22374 7 30,842,957 972 FLJ22374 7 30,843,167 973 PDE1C 7 31,841,400 974 PDE1C 7 32,064,508 975 PDE1C 7 32,141,959 976 BMPER 7 33,942,093 977 BMPER 7 33,994,557 978 BMPER 7 34,050,872 979 BMPER 7 34,056,348 980 BMPER 7 34,077,080 981 BMPER 7 34,077,746 982 BMPER 7 34,107,862 983 VPS41 7 38,759,185 984 VPS41 7 38,859,847 985 VPS41 7 38,882,602 986 VPS41 7 38,936,691 987 CDC2L5 7 40,056,457 988 CDC2L5 7 40,083,623 989 CDC2L5 7 40,124,213 990 CDC2L5 7 40,125,052 991 SDK1 7 4,140,139 992 SDK1 7 4,230,185

993 SDK1 7 4,272,360 994 IGFBP3 7 45,916,971 995 IGFBP3 7 45,990,559 996 IGFBP3 7 46,061,993 997 ABCA13 7 48,380,796 998 ABCA13 7 48,399,261 999 ABCA13 7 48,425,013 1000 ABCA13 7 48,425,630 1001 ABCA13 7 48,656,578 1002 ABCA13 7 48,681,043 1003 GRB10 7 50,707,082 1004 GRB10 7 50,727,714 1005 WBSCR17 7 69,982,663 1006 WBSCR17 7 70,020,032 1007 WBSCR17 7 70,024,662 1008 WBSCR17 7 70,327,601 1009 WBSCR17 7 70,328,803 1010 WBSCR17 7 70,508,901 1011 LIMK1 7 73,155,050 1012 LIMK1 7 73,189,576 1013 LIMK1 7 73,201,992 1014 GTF2IRD1 7 73,552,324 1015 HIP1 7 74,641,558 1016 HIP1 7 75,137,795 1017 HIP1 7 75,149,973 1018 HIP1 7 75,189,895 1019 MAGI2 7 77,497,177 1020 MAGI2 7 77,707,944 1021 MAGI2 7 78,081,016 1022 MAGI2 7 78,087,129 1023 MAGI2 7 78,091,049 1024 MAGI2 7 78,331,358 1025 MAGI2 7 78,639,527 1026 MAGI2 7 78,753,565 1027 MAGI2 7 78,779,395 1028 MAGI2 7 78,817,962 1029 MAGI2 7 78,865,894 1030 MAGI2 7 78,873,419 1031 MAGI2 7 78,902,124 1032 CACNA2D1 7 81,000,419 1033 CACNA2D1 7 81,501,211 1034 CACNA2D1 7 81,551,628 1035 PCLO 7 81,734,489 1036 CACNA2D1 7 81,827,271 1037 CACNA2D1 7 81,829,947 1038 CACNA2D1 7 81,841,829 1039 CACNA2D1 7 81,844,366 1040 CACNA2D1 7 81,846,503 1041 PCLO 7 82,252,869 1042 PCLO 7 82,287,971 1043 PCLO 7 82,291,644 1044 PCLO 7 82,292,608 1045 PCLO 7 82,317,658 1046 PCLO 7 82,341,345 1047 PCLO 7 82,341,378 1048 PCLO 7 82,358,102 1049 PCLO 7 82,391,885 1050 PCLO 7 82,562,475 1051 PCLO 7 82,567,345 1052 PCLO 7 82,573,554 1053 PCLO 7 82,573,594 1054 PCLO 7 82,636,908 1055 PCLO 7 82,659,120 1056 SEMA3E 7 82,895,964 1057 SEMA3E 7 82,901,024 1058 SEMA3A 7 82,965,762 1059 SEMA3E 7 83,047,248 1060 SEMA3E 7 83,061,152 1061 SEMA3E 7 83,125,543 1062 SEMA3A 7 83,451,819 1063 SEMA3A 7 83,559,228 1064 SEMA3A 7 83,559,858 1065 SEMA3A 7 83,564,904 1066 SEMA3A 7 83,565,919 1067 SEMA3A 7 83,568,098 1068 SEMA3A 7 83,571,382 1069 SEMA3A 7 83,572,529 1070 SEMA3A 7 83,573,829 1071 NXPH1 7 8,662,332 1072 ABCB4 7 86,868,839 1073 ABCB4 7 86,883,520 1074 ABCB4 7 86,897,339 1075 ADAM22 7 87,086,253 1076 ADAM22 7 87,441,679 1077 ADAM22 7 87,471,187 1078 ADAM22 7 87,471,440 1079 ADAM22 7 87,554,236 1080 ADAM22 7 87,557,024 1081 ADAM22 7 87,579,450 1082 ADAM22 7 87,606,110 1083 ADAM22 7 87,613,210 1084 ADAM22 7 87,632,643 1085 ADAM22 7 87,634,202 1086 NXPH1 7 8,780,133 1087 PPP1R9A 7 94,747,598 1088 PPP1R9A 7 94,772,391 1089 PON1 7 94,776,112 1090 PON1 7 94,776,193 1091 PON1 7 94,784,507 1092 DYNC1I1 7 95,385,967 1093 DYNC1I1 7 95,451,958 1094 GRHL2 8 102,577,101 1095 GRHL2 8 102,580,894 1096 GRHL2 8 102,718,857 1097 GRHL2 8 102,740,588 1098 NCALD 8 102,769,504 1099 NCALD 8 102,769,812 1100 NCALD 8 102,777,547 1101 NCALD 8 102,812,988 1102 ZFPM2 8 106,505,157 1103 ZFPM2 8 106,521,287 1104 ZFPM2 8 106,530,047 1105 ZFPM2 8 106,567,598 1106 ZFPM2 8 106,614,970 1107 ZFPM2 8 106,794,185 1108 ZFPM2 8 106,803,045 1109 ZFPM2 8 106,828,892 1110 ZFPM2 8 106,841,629 1111 CSMD3 8 113,479,682 1112 CSMD3 8 113,554,821 1113 CSMD3 8 113,568,517 1114 CSMD3 8 113,570,484 1115 CSMD3 8 114,319,937 1116 CSMD3 8 114,432,523 1117 CSMD3 8 114,441,419 1118 CSMD3 8 114,475,512 1119 SAMD12 8 119,514,024 1120 SAMD12 8 119,530,374 1121 SAMD12 8 119,532,252 1122 SAMD12 8 119,536,976 1123 SAMD12 8 119,671,788 1124 FBXO32 8 124,567,915 1125 FBXO32 8 124,583,159 1126 FER1L6 8 124,996,892 1127 FER1L6 8 125,011,048 1128 FER1L6 8 125,014,271 1129 FER1L6 8 125,014,506 1130 FER1L6 8 125,020,334 1131 FER1L6 8 125,032,627 1132 FER1L6 8 125,053,616 1133 FER1L6 8 125,102,576 1134 FER1L6 8 125,104,714 1135 FER1L6 8 125,108,933 1136 FER1L6 8 125,218,759 1137 MTSS1 8 125,649,171 1138 MTSS1 8 125,651,280 1139 DLC1 8 13,014,125 1140 DDEF1 8 131,407,018 1141 ADCY8 8 131,972,316 1142 ADCY8 8 131,983,404 1143 ADCY8 8 131,985,500 1144 ADCY8 8 131,997,583 1145 KCNQ3 8 133,208,937 1146 KCNQ3 8 133,473,613 1147 ST3GAL1 8 134,609,061 1148 ST3GAL1 8 134,610,724 1149 ST3GAL1 8 134,664,388 1150 COL22A1 8 139,668,834 1151 COL22A1 8 139,892,385 1152 COL22A1 8 139,901,545 1153 SGCZ 8 14,059,709 1154 SGCZ 8 14,594,583 1155 SGCZ 8 14,876,643 1156 SGCZ 8 14,898,152 1157 SLC7A2 8 17,431,231 1158 SLC7A2 8 17,431,383 1159 SLC7A2 8 17,480,455 1160 PSD3 8 18,708,574 1161 PSD3 8 18,709,420 1162 PSD3 8 18,732,409 1163 PSD3 8 18,737,733 1164 PSD3 8 18,749,712 1165 PSD3 8 18,757,428 1166 PSD3 8 18,765,584 1167 PSD3 8 18,773,018 1168 PSD3 8 18,819,182 1169 PSD3 8 18,953,685 1170 ATP6V1B2 8 20,135,799 1171 GFRA2 8 21,616,512 1172 PEBP4 8 22,632,507 1173 ENTPD4 8 23,353,499 1174 SLC25A37 8 23,453,211 1175 SLC25A37 8 23,471,600 1176 CSMD1 8 2,849,233 1177 CSMD1 8 2,864,416 1178 CSMD1 8 2,958,438 1179 CSMD1 8 3,206,762 1180 CSMD1 8 3,209,023 1181 CSMD1 8 3,211,642 1182 CSMD1 8 3,216,613 1183 CSMD1 8 3,245,103 1184 CSMD1 8 3,275,090 1185 CSMD1 8 3,292,328 1186 UNC5D 8 35,516,694 1187 UNC5D 8 35,586,829 1188 SFRP1 8 41,244,318 1189 SFRP1 8 41,247,567 1190 SFRP1 8 41,247,867 1191 SFRP1 8 41,262,183 1192 SFRP1 8 41,284,951 1193 SNTG1 8 50,981,354 1194 SNTG1 8 51,028,383 1195 SNTG1 8 51,082,766 1196 SNTG1 8 51,127,991 1197 MCPH1 8 6,266,787 1198 MCPH1 8 6,290,817 1199 MCPH1 8 6,290,919 1200 MCPH1 8 6,297,826 1201 MCPH1 8 6,306,930 1202 MCPH1 8 6,307,055 1203 MCPH1 8 6,307,171 1204 MCPH1 8 6,313,383 1205 MCPH1 8 6,316,969 1206 NKAIN3 8 63,450,524 1207 NKAIN3 8 63,573,341 1208 MCPH1 8 6,357,338 1209 MCPH1 8 6,362,452 1210 NKAIN3 8 63,670,367 1211 NKAIN3 8 63,897,057 1212 NKAIN3 8 64,008,938 1213 NKAIN3 8 64,056,708 1214 NKAIN3 8 64,084,956 1215 MCPH1 8 6,460,526 1216 DEPDC2 8 69,098,456 1217 DEPDC2 8 69,098,725 1218 DEPDC2 8 69,121,712 1219 DEPDC2 8 69,144,533 1220 DEPDC2 8 69,156,370 1221 DEPDC2 8 69,207,400 1222 DEPDC2 8 69,209,296 1223 DEPDC2 8 69,301,731 1224 DEPDC2 8 69,314,054 1225 KCNB2 8 73,614,029 1226 KCNB2 8 73,618,324 1227 KCNB2 8 73,754,111 1228 KCNB2 8 73,756,664 1229 KCNB2 8 73,762,984 1230 KCNB2 8 73,776,211 1231 KCNB2 8 73,783,806 1232 KCNB2 8 73,813,319 1233 MMP16 8 89,061,627 1234 MMP16 8 89,120,413 1235 MMP16 8 89,148,139 1236 MMP16 8 89,337,659 1237 MMP16 8 89,367,315 1238 MMP16 8 89,392,120 1239 MMP16 8 89,413,738 1240 MMP16 8 89,414,303 1241 MMP16 8 89,421,430 1242 GABBR2 9 100,094,975 1243 GABBR2 9 100,095,943 1244 GABBR2 9 100,419,601 1245 GABBR2 9 100,469,409 1246 RP11-35N6.1 9 102,472,272 1247 FER1L6 9 103,382,443 1248 GRIN3A 9 103,473,056 1249 GRIN3A 9 103,521,201 1250 FKTN 9 107,409,195 1251 FKTN 9 107,449,221 1252 FKTN 9 107,455,377 1253 SVEP1 9 112,152,393 1254 SVEP1 9 112,166,117 1255 SVEP1 9 112,167,878 1256 CDK5RAP2 9 122,209,539 1257 CDK5RAP2 9 122,337,266 1258 CDK5RAP2 9 122,362,134 1259 CDK5RAP2 9 122,370,634 1260 STOM 9 123,165,341 1261 DAB2IP 9 123,691,611 1262 RALGPS1 9 128,698,499 1263 RALGPS1 9 128,769,224 1264 RALGPS1 9 128,789,061 1265 RALGPS1 9 128,809,594 1266 RALGPS1 9 128,902,817 1267 SLC25A25 9 129,886,889 1268 SLC25A25 9 129,899,153 1269 FREQ 9 131,997,035 1270 EXOSC2 9 132,588,852 1271 ABL1 9 132,715,588 1272 ABL1 9 132,721,005 1273 ABL1 9 132,722,573 1274 ABL1 9 132,723,896 1275 TSC1 9 134,811,193 1276 TSC1 9 134,812,111 1277 VAV2 9 135,795,115 1278 OLFM1 9 137,113,249 1279 OLFM1 9 137,127,054 1280 INPP5E 9 138,461,433 1281 NOTCH1 9 138,555,218 1282 CACNA1B 9 140,072,737 1283 CACNA1B 9 140,075,368 1284 ASAH3L 9 19,460,804 1285 KIAA1797 9 20,673,404 1286 KIAA1797 9 20,678,117 1287 KIAA1797 9 20,732,210 1288 KIAA1797 9 20,753,840 1289 KIAA1797 9 20,754,870 1290 KIAA1797 9 20,804,142 1291 KIAA1797 9 20,898,513 1292 KIAA1797 9 20,921,349 1293 KIAA1797 9 20,935,372 1294 KIAA1797 9 20,943,233 1295 KIAA1797 9 20,943,335 1296 KIAA1797 9 20,943,750 1297 KIAA1797 9 20,951,906 1298 KIAA1797 9 20,977,703 1299 KIAA1797 9 20,978,426 1300 KIAA1797 9 20,986,709 1301 SMARCA2 9 2,120,828 1302 SMARCA2 9 2,120,917 1303 SMARCA2 9 2,121,990 1304 SMARCA2 9 2,178,383 1305 IFT74 9 26,999,100 1306 TEK 9 27,129,817 1307 TEK 9 27,175,101 1308 TEK 9 27,210,066 1309 TEK 9 27,224,049 1310 SLC1A1 9 4,550,348 1311 SLC1A1 9 4,552,472 1312 PIP5K1B 9 70,507,948 1313 PIP5K1B 9 70,552,216 1314 PIP5K1B 9 70,672,108 1315 PIP5K1B 9 70,687,329 1316 PIP5K1B 9 70,691,508 1317 PIP5K1B 9 70,703,782 1318 APBA1 9 71,324,196 1319 TRPM3 9 72,346,211 1320 TRPM3 9 72,637,875 1321 TRPM3 9 72,648,924 1322 TRPM3 9 72,649,911 1323 TRPM3 9 72,673,741 1324 TMC1 9 74,397,486 1325 TMC1 9 74,443,712 1326 TMC1 9 74,579,921 1327 PCSK5 9 77,687,086 1328 PCSK5 9 77,896,771 1329 PCSK5 9 77,912,756 1330 GNAQ 9 79,595,252 1331 GNAQ 9 79,703,143 1332 GNAQ 9 79,908,612 1333 PTPRD 9 8,372,966 1334 PTPRD 9 8,390,681 1335 NTRK2 9 86,472,851 1336 NTRK2 9 86,479,077 1337 NTRK2 9 86,599,187 1338 DAPK1 9 89,448,453 1339 DAPK1 9 89,452,483 1340 DAPK1 9 89,511,843 1341 SORCS3 10 106,371,034 1342 SORCS3 10 106,592,352 1343 SORCS3 10 106,614,338 1344 SORCS3 10 106,622,111 1345 SORCS3 10 106,622,468 1346 SORCS3 10 106,625,786 1347 SORCS3 10 106,777,753 1348 SORCS3 10 106,782,237 1349 SORCS3 10 106,897,228 1350 SORCS3 10 106,906,037 1351 SORCS3 10 106,906,641 1352 SORCS3 10 107,025,958 1353 CUGBP2 10 11,277,934 1354 VTI1A 10 114,226,855 1355 VTI1A 10 114,228,361 1356 VTI1A 10 114,424,611 1357 VTI1A 10 114,458,106 1358 VTI1A 10 114,458,428 1359 VTI1A 10 114,506,363 1360 VTI1A 10 114,508,308 1361 HSPA12A 10 118,432,901 1362 HSPA12A 10 118,469,221 1363 ATE1 10 123,432,831 1364 ATE1 10 123,450,896 1365 ATE1 10 123,453,723 1366 ATE1 10 123,644,015 1367 ATE1 10 123,651,712 1368 ATE1 10 123,663,196 1369 ATE1 10 123,669,674 1370 CTBP2 10 126,677,518 1371 ARMC3 10 23,277,574 1372 ARMC3 10 23,289,115 1373 ARMC3 10 23,314,154 1374 ARMC3 10 23,318,053 1375 ARMC3 10 23,337,258 1376 ARMC3 10 23,364,367 1377 ARMC3 10 23,372,952 1378 ARHGAP21 10 25,046,553 1379 MYO3A 10 26,398,660 1380 MYO3A 10 26,552,050 1381 PITRM1 10 3,166,363 1382 PITRM1 10 3,169,968 1383 PITRM1 10 3,179,380 1384 PITRM1 10 3,192,065 1385 PITRM1 10 3,213,179 1386 SLC16A9 10 61,024,452 1387 SLC16A9 10 61,082,341 1388 SLC16A9 10 61,084,017 1389 SLC16A9 10 61,120,938 1390 SLC16A9 10 61,122,758 1391 PRKCQ 10 6,567,350 1392 PRKCQ 10 7,152,082 1393 CDH23 10 72,997,429 1394 CDH23 10 73,104,912 1395 CDH23 10 73,126,384 1396 KCNMA1 10 78,319,405 1397 KCNMA1 10 78,319,936 1398 KCNMA1 10 78,320,267 1399 KCNMA1 10 78,324,802 1400 KCNMA1 10 78,348,173 1401 KCNMA1 10 78,626,486 1402 KCNMA1 10 78,738,970 1403 KCNMA1 10 78,757,625 1404 KCNMA1 10 78,799,763 1405 KCNMA1 10 78,817,839 1406 KCNMA1 10 78,872,456 1407 KCNMA1 10 79,094,637 1408 NRG3 10 84,068,972 1409 NRG3 10 84,070,208 1410 NRG3 10 84,604,364 1411 NRG3 10 84,613,706 1412 NRG3 10 84,616,939 1413 SORBS1 10 97,061,507 1414 SORBS1 10 97,122,546 1415 SORBS1 10 97,122,783 1416 SORBS1 10 97,126,192 1417 SORBS1 10 97,127,095 1418 SORBS1 10 97,216,419 1419 ELMOD1 11 107,077,060 1420 GALNTL4 11 11,246,740 1421 GALNTL4 11 11,497,136 1422 MICAL2 11 12,139,036 1423 MICAL2 11 12,142,872 1424 MICAL2 11 12,149,199 1425 MICAL2 11 12,155,884 1426 MICAL2 11 12,175,779 1427 MICAL2 11 12,222,118 1428 OPCML 11 131,718,194 1429 OPCML 11 132,078,600 1430 ARNTL 11 13,212,114 1431 ARNTL 11 13,212,547 1432 OPCML 11 132,803,817 1433 OPCML 11 132,884,694 1434 OPCML 11 132,895,944 1435 SPON1 11 13,882,655 1436 SPON1 11 13,922,920 1437 SPON1 11 13,994,054 1438 SPON1 11 14,008,775 1439 SPON1 11 14,014,762 1440 SPON1 11 14,023,125 1441 SPON1 11 14,034,087 1442 SPON1 11 14,070,335 1443 SPON1 11 14,075,677 1444 SPON1 11 14,215,231 1445 INSC 11 15,138,272 1446 KCNA4 11 29,964,590 1447 KCNA4 11 29,984,859 1448 STIM1 11 3,847,536 1449 STIM1 11 3,867,621 1450 STIM1 11 3,927,655 1451 STIM1 11 4,033,624 1452 TRIM21 11 4,371,449 1453 C11ORF49 11 47,089,300 1454 81.99 mb 11 81,921,684 1455 DLG2 11 82,719,582 1456 DLG2 11 82,720,706 1457 DLG2 11 82,743,548 1458 DLG2 11 82,843,293 1459 DLG2 11 82,856,041 1460 DLG2 11 82,974,099 1461 DLG2 11 82,982,760 1462 DLG2 11 83,366,230 1463 DLG2 11 83,418,483 1464 DLG2 11 83,444,686 1465 DLG2 11 83,457,074 1466 DLG2 11 84,138,503 1467 DLG2 11 84,147,518 1468 DLG2 11 84,153,124 1469 DLG2 11 84,214,566 1470 DLG2 11 84,251,688 1471 DLG2 11 84,251,805 1472 DLG2 11 84,261,681 1473 DLG2 11 84,273,766 1474 DLG2 11 84,283,321 1475 DLG2 11 84,283,477 1476 DLG2 11 84,425,370 1477 CHST11 12 103,435,376 1478 CHST11 12 103,448,913 1479 CHST11 12 103,599,400 1480 ATXN2 12 110,547,258 1481 PLA2G1B 12 119,254,040 1482 LOC729025 12 16,298,403 1483 LOC729025 12 16,302,981 1484 PIK3C2G 12 18,305,520 1485 PIK3C2G 12 18,356,504 1486 PIK3C2G 12 18,426,133 1487 PIK3C2G 12 18,576,788 1488 PIK3C2G 12 18,701,315 1489 ITPR2 12 26,366,134 1490 ITPR2 12 26,382,742 1491 TMEM16B 12 5,505,585 1492 LRP1 12 55,821,533 1493 TMEM16B 12 5,690,939 1494 TMEM16B 12 5,712,102

1495 TMEM16B 12 5,755,581 1496 TMEM16B 12 5,760,697 1497 TMEM16B 12 5,786,169 1498 TMEM16B 12 5,794,409 1499 TMEM16B 12 5,901,003 1500 CNOT2 12 68,831,198 1501 CNOT2 12 69,026,461 1502 KCNC2 12 73,877,027 1503 KCNC2 12 73,886,479 1504 KCNC2 12 73,898,155 1505 KCNC2 12 73,944,836 1506 NAV3 12 76,718,256 1507 NAV3 12 76,748,290 1508 NAV3 12 76,793,282 1509 NAV3 12 76,798,556 1510 NAV3 12 76,824,819 1511 NAV3 12 76,839,838 1512 NAV3 12 76,845,308 1513 NAV3 12 76,854,382 1514 NAV3 12 76,862,517 1515 NAV3 12 76,862,929 1516 NAV3 12 76,893,657 1517 NAV3 12 76,913,545 1518 NAV3 12 76,922,312 1519 NAV3 12 77,013,958 1520 NALCN 13 100,607,424 1521 NALCN 13 100,611,279 1522 NALCN 13 100,618,459 1523 NALCN 13 100,631,451 1524 NALCN 13 100,633,744 1525 NALCN 13 100,638,349 1526 NALCN 13 100,645,729 1527 NALCN 13 100,686,017 1528 NALCN 13 100,689,460 1529 NALCN 13 100,803,215 1530 ITGBL1 13 100,951,158 1531 ITGBL1 13 101,018,194 1532 ITGBL1 13 101,066,640 1533 ITGBL1 13 101,070,551 1534 ITGBL1 13 101,071,354 1535 ITGBL1 13 101,088,453 1536 ITGBL1 13 101,144,171 1537 FGF14 13 101,180,363 1538 FGF14 13 101,217,477 1539 FGF14 13 101,224,288 1540 FGF14 13 101,237,184 1541 FGF14 13 101,904,537 1542 MTIF3 13 26,979,535 1543 N4BP2L2 13 31,899,297 1544 N4BP2L2 13 31,934,759 1545 N4BP2L2 13 31,953,620 1546 N4BP2L2 13 32,021,516 1547 NBEA 13 34,773,125 1548 NBEA 13 34,848,999 1549 NBEA 13 35,142,667 1550 NBEA 13 35,170,524 1551 NBEA 13 35,171,922 1552 TRPC4 13 37,131,370 1553 TRPC4 13 37,131,795 1554 TRPC4 13 37,134,885 1555 TRPC4 13 37,134,956 1556 TRPC4 13 37,135,147 1557 TRPC4 13 37,148,211 1558 TRPC4 13 37,201,686 1559 TRPC4 13 37,203,414 1560 TRPC4 13 37,259,744 1561 TRPC4 13 37,316,370 1562 TRPC4 13 37,343,196 1563 TRPC4 13 37,343,288 1564 TRPC4 13 37,354,793 1565 FNDC3A 13 48,484,019 1566 FNDC3A 13 48,526,907 1567 FNDC3A 13 48,569,216 1568 FNDC3A 13 48,609,971 1569 KPNA3 13 49,294,756 1570 PCDH17 13 57,113,277 1571 PCDH17 13 57,133,204 1572 SLAIN1 13 77,130,842 1573 SLAIN1 13 77,151,328 1574 SLAIN1 13 77,192,452 1575 SLAIN1 13 77,211,551 1576 SLAIN1 13 77,232,218 1577 SLAIN1 13 77,273,814 1578 SLAIN1 13 77,290,759 1579 GPC5 13 90,547,957 1580 GPC5 13 90,931,610 1581 GPC5 13 91,966,983 1582 GPC5 13 92,117,714 1583 GPC5 13 92,121,270 1584 GPC5 13 92,275,844 1585 GPC5 13 92,302,532 1586 GPC5 13 92,332,949 1587 GPC5 13 92,347,342 1588 GPC6 13 92,775,697 1589 GPC6 13 92,807,479 1590 GPC6 13 93,185,878 1591 GPC6 13 93,196,895 1592 GPC6 13 93,196,981 1593 GPC6 13 93,204,846 1594 GPC6 13 93,497,436 1595 GPC6 13 93,851,561 1596 GPC6 13 93,863,575 1597 NPAS3 14 32,590,670 1598 NPAS3 14 32,661,665 1599 NPAS3 14 32,777,738 1600 NPAS3 14 32,782,805 1601 NPAS3 14 32,983,731 1602 NPAS3 14 33,099,951 1603 NPAS3 14 33,099,995 1604 NPAS3 14 33,192,848 1605 NPAS3 14 33,194,275 1606 NPAS3 14 33,206,451 1607 NPAS3 14 33,207,004 1608 SLC25A21 14 36,242,267 1609 SLC25A21 14 36,419,536 1610 LRFN5 14 41,384,489 1611 LRFN5 14 41,391,684 1612 GNG2 14 51,400,583 1613 GNG2 14 51,409,101 1614 GNG2 14 51,428,644 1615 GNG2 14 51,520,930 1616 SAMD4A 14 54,112,365 1617 SAMD4A 14 54,314,899 1618 SAMD4A 14 54,319,095 1619 SAMD4A 14 54,335,321 1620 PPP2R5E 14 62,858,991 1621 PPP2R5E 14 63,091,961 1622 PPP2R5E 14 63,099,534 1623 PPP2R5E 14 63,213,578 1624 RGS6 14 71,479,105 1625 RGS6 14 71,524,688 1626 RGS6 14 71,532,447 1627 RGS6 14 71,538,158 1628 RGS6 14 71,730,259 1629 RGS6 14 71,789,160 1630 RGS6 14 71,870,813 1631 RGS6 14 71,979,491 1632 KCNK10 14 87,843,799 1633 KCNK10 14 87,887,777 1634 RPS6KA5 14 90,431,677 1635 RPS6KA5 14 90,501,524 1636 RPS6KA5 14 90,536,260 1637 RPS6KA5 14 90,572,871 1638 RPS6KA5 14 90,592,117 1639 RPS6KA5 14 90,600,783 1640 RPS6KA5 14 90,600,927 1641 RPS6KA5 14 90,616,889 1642 CCDC88C 14 90,910,934 1643 CCDC88C 14 90,916,433 1644 CCDC88C 14 90,918,598 1645 CCDC88C 14 90,919,949 1646 CCDC88C 14 90,920,049 1647 CCDC88C 14 90,926,910 1648 BCL11B 14 98,713,688 1649 BCL11B 14 98,742,719 1650 BCL11B 14 98,816,027 1651 ATP10A 15 23,478,440 1652 ATP10A 15 23,496,935 1653 RYR3 15 31,550,764 1654 RYR3 15 31,564,997 1655 RYR3 15 31,695,608 1656 RYR3 15 31,744,674 1657 RYR3 15 31,745,083 1658 RYR3 15 31,814,492 1659 RYR3 15 31,815,285 1660 RYR3 15 31,899,901 1661 C15ORF41 15 34,691,218 1662 C15ORF41 15 34,707,884 1663 C15ORF41 15 34,751,160 1664 C15ORF41 15 34,755,325 1665 C15ORF41 15 34,780,489 1666 C15ORF41 15 34,793,623 1667 C15ORF41 15 34,833,829 1668 RASGRP1 15 36,607,181 1669 PLA2G4D 15 40,137,329 1670 GLDN 15 49,440,552 1671 GLDN 15 49,477,064 1672 GLDN 15 49,481,784 1673 CGNL1 15 55,403,598 1674 CGNL1 15 55,518,865 1675 CGNL1 15 55,521,306 1676 CGNL1 15 55,595,257 1677 CGNL1 15 55,623,195 1678 CGNL1 15 55,623,569 1679 RORA 15 58,605,378 1680 RORA 15 58,680,723 1681 CLK3 15 72,697,052 1682 TBC1D2B 15 76,096,608 1683 TBC1D2B 15 76,098,398 1684 TBC1D2B 15 76,121,710 1685 TBC1D2B 15 76,150,830 1686 ARNT2 15 78,539,124 1687 ARNT2 15 78,700,178 1688 ARNT2 15 78,703,747 1689 ARNT2 15 78,704,322 1690 ARNT2 15 78,718,605 1691 ARNT2 15 78,719,745 1692 SH3GL3 15 81,818,542 1693 PCSK6 15 99,842,741 1694 TMC5 16 19,254,444 1695 GDE1 16 19,447,359 1696 EEF2K 16 22,114,775 1697 KIFC3 16 56,376,436 1698 KIFC3 16 56,379,768 1699 A2BP1 16 6,527,248 1700 A2BP1 16 6,528,853 1701 A2BP1 16 6,691,358 1702 A2BP1 16 6,974,269 1703 HYDIN 16 69,783,066 1704 A2BP1 16 6,980,934 1705 HYDIN 16 69,818,152 1706 A2BP1 16 7,234,640 1707 A2BP1 16 7,551,379 1708 WWOX 16 76,643,771 1709 WWOX 16 76,655,506 1710 WWOX 16 76,669,786 1711 WWOX 16 76,672,696 1712 WWOX 16 76,674,781 1713 WWOX 16 77,016,308 1714 MPHOSPH6 16 80,705,905 1715 MPHOSPH6 16 80,722,907 1716 MPHOSPH6 16 80,723,078 1717 MPHOSPH6 16 80,728,084 1718 CDH13 16 81,390,450 1719 CDH13 16 81,426,803 1720 CDH13 16 81,436,845 1721 CDH13 16 81,470,072 1722 CDH13 16 81,474,183 1723 CDH13 16 81,477,191 1724 CDH13 16 81,481,182 1725 CDH13 16 81,487,112 1726 CDH13 16 81,906,325 1727 CDH13 16 81,917,154 1728 CDH13 16 81,919,816 1729 CDH13 16 82,194,302 1730 CDH13 16 82,357,323 1731 USP10 16 83,331,937 1732 USP10 16 83,371,654 1733 CRISPLD2 16 83,443,278 1734 CRISPLD2 16 83,443,531 1735 CRISPLD2 16 83,475,493 1736 CRISPLD2 16 83,476,363 1737 CRISPLD2 16 83,484,480 1738 CRISPLD2 16 83,484,845 1739 CRISPLD2 16 83,497,517 1740 DNAH9 17 11,591,782 1741 DNAH9 17 11,672,736 1742 DNAH9 17 11,862,669 1743 RAB11FIP4 17 27,005,299 1744 CA10 17 47,163,241 1745 CA10 17 47,434,848 1746 CA10 17 47,528,183 1747 CA10 17 47,534,336 1748 CA10 17 47,547,164 1749 CA10 17 47,599,744 1750 CA10 17 48,292,853 1751 MSI2 17 52,817,244 1752 MSI2 17 52,993,137 1753 MSI2 17 53,122,443 1754 SDK2 17 68,829,410 1755 HRNBP3 17 74,857,410 1756 HRNBP3 17 75,313,214 1757 OSBPL1A 18 20,042,294 1758 OSBPL1A 18 20,093,929 1759 OSBPL1A 18 20,243,361 1760 CHST9 18 22,886,548 1761 CHST9 18 22,965,754 1762 CHST9 18 23,000,286 1763 DLGAP1 18 3,829,680 1764 DLGAP1 18 3,840,002 1765 ZFP161 18 5,398,814 1766 NEDD4L 18 54,010,852 1767 NEDD4L 18 54,013,845 1768 NEDD4L 18 54,014,157 1769 NEDD4L 18 54,016,611 1770 NEDD4L 18 54,028,916 1771 NEDD4L 18 54,100,941 1772 NEDD4L 18 54,258,677 1773 NEDD4L 18 54,259,246 1774 CCBE1 18 55,241,702 1775 CCBE1 18 55,487,763 1776 CDH7 18 61,273,210 1777 CDH7 18 61,289,294 1778 CDH7 18 61,305,341 1779 CDH7 18 61,305,944 1780 CDH7 18 61,586,240 1781 CDH7 18 61,590,121 1782 CDH7 18 61,594,009 1783 CDH7 18 61,594,926 1784 CDH7 18 61,594,980 1785 CDH7 18 61,595,280 1786 CDH7 18 61,595,696 1787 CDH7 18 61,627,079 1788 CDH7 18 61,668,497 1789 CDH7 18 61,688,917 1790 CDH7 18 61,715,545 1791 DOK6 18 65,238,984 1792 DOK6 18 65,437,835 1793 DOK6 18 65,516,648 1794 DOK6 18 65,516,906 1795 MBP 18 72,823,708 1796 MBP 18 73,018,369 1797 PTPRM 18 7,522,635 1798 PTPRM 18 7,585,927 1799 PTPRM 18 8,277,805 1800 PTPRM 18 8,288,088 1801 PTPRM 18 8,288,633 1802 KIAA0802 18 8,689,988 1803 KIAA0802 18 8,788,185 1804 KIAA0802 18 8,820,180 1805 LDLR 19 11,067,530 1806 LDLR 19 11,102,877 1807 LDLR 19 11,103,658 1808 ZNF667 19 61,678,984 1809 MACROD2 20 14,275,899 1810 MACROD2 20 15,551,153 1811 MACROD2 20 15,890,876 1812 MACROD2 20 15,992,978 1813 KIF16B 20 16,221,665 1814 KIF16B 20 16,221,933 1815 KIF16B 20 16,270,199 1816 KIF16B 20 16,275,325 1817 KIF16B 20 16,275,825 1818 KIF16B 20 16,284,694 1819 KIF16B 20 16,294,439 1820 KIF16B 20 16,294,523 1821 KIF16B 20 16,307,567 1822 KIF16B 20 16,314,615 1823 KIF16B 20 16,371,330 1824 KIF16B 20 16,420,825 1825 KIF16B 20 16,459,991 1826 KIF16B 20 16,476,914 1827 KIF16B 20 16,591,934 1828 MAPRE1 20 30,888,730 1829 MAPRE1 20 30,891,296 1830 PTPRT 20 40,079,104 1831 PTPRT 20 40,112,645 1832 PTPRT 20 40,141,648 1833 PTPRT 20 40,143,404 1834 PTPRT 20 40,153,367 1835 PTPRT 20 40,176,580 1836 PTPRT 20 40,534,688 1837 PTPRT 20 40,759,651 1838 PTPRT 20 40,766,955 1839 PTPRT 20 40,832,585 1840 PRNT 20 4,676,075 1841 KCNB1 20 47,439,714 1842 KCNB1 20 47,440,607 1843 KCNB1 20 47,543,084 1844 KCNB1 20 47,550,362 1845 KCNB1 20 47,554,184 1846 CDH4 20 59,349,681 1847 CDH4 20 59,359,672 1848 CDH4 20 59,708,754 1849 CDH4 20 59,852,651 1850 CDH4 20 59,854,564 1851 CDH4 20 59,936,745 1852 FERMT1 20 6,011,187 1853 FERMT1 20 6,037,797 1854 FERMT1 20 6,048,088 1855 FERMT1 20 6,162,234 1856 PLCB1 20 8,082,140 1857 PLCB1 20 8,092,135 1858 PLCB1 20 8,159,200 1859 PLCB4 20 9,133,981 1860 PLCB4 20 9,173,164 1861 C21ORF37 21 17,711,037 1862 NCAM2 21 21,717,043 1863 NCAM2 21 21,722,038 1864 NCAM2 21 21,849,510 1865 ERG 21 38,941,206 1866 ERG 21 38,947,119 1867 ERG 21 38,989,365 1868 PCP4 21 40,145,066 1869 PCP4 21 40,147,412 1870 SLC37A1 21 42,866,712 1871 SLC37A1 21 42,871,651 1872 SLC37A1 21 42,877,191 1873 ARVCF 22 18,342,203 1874 SGSM1 22 23,675,537 1875 HPS4 22 25,192,153 1876 ARFGAP3 22 41,576,090 1877 ARFGAP3 22 41,590,371 1878 ARFGAP3 22 41,591,167 1879 PACSIN2 22 41,629,654 1880 PACSIN2 22 41,645,337 1881 PACSIN2 22 41,679,576 1882 PACSIN2 22 41,685,200 1883 PACSIN2 22 41,686,443 1884 PACSIN2 22 41,686,643 1885 PACSIN2 22 41,723,929 1886 PACSIN2 22 41,726,053 1887 PACSIN2 22 41,727,507 1888 PACSIN2 22 41,729,950 1889 PACSIN2 22 41,730,708 1890 TTLL1 22 41,796,161 1891 TTLL1 22 41,822,583 1892 TTLL1 22 41,822,906 1893 EFCAB6 22 42,278,436 1894 EFCAB6 22 42,320,777

Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 1894 <210> SEQ ID NO 1 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1 gcagtactca cccaaattgc ttctgtctca rtgataccaa gcactattct ttaatttcct 60 t 61 <210> SEQ ID NO 2 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 2 gcttacttga actgacagaa gatatctgca yactctggga ggattccact ggcctgcaac 60 a 61 <210> SEQ ID NO 3 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 3 gcgcccagcc tgatgagtga ctttaattgc kctatgcttc agtcatctca gctaacacag 60 g 61 <210> SEQ ID NO 4 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 4 ttggcgtatg gttctttagg atgattgaca rtggcagtac ctggactaac gtgactttag 60 c 61 <210> SEQ ID NO 5 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 5 gagacctgga ctttagaccc tctaccccca rttagctgtg agaccttgag caaatcattt 60 c 61 <210> SEQ ID NO 6 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 6 gacgctttgt gaattcataa caagggctcc nagtcaccag atcttagagc tgacccagtg 60 c 61 <210> SEQ ID NO 7 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 7 tctttcttag ctgcctggta ttaactcatg sggacgttct ggatcctggg agaatccaga 60 t 61 <210> SEQ ID NO 8 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 8 ttttccctaa cttcagtcat ctgagtaccc yttgctagtt ttcacatgcc cattttctgt 60 c 61 <210> SEQ ID NO 9 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 9 ttgttgagtg atgcatgaca tatgactgtt ygttgtcctc atttgaatgc atgtgccttg 60 a 61 <210> SEQ ID NO 10 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 10 ttggaacagc acccagacag gcctctaaag yacaaagcag aagtacagtg cgtgaactaa 60 c 61 <210> SEQ ID NO 11 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 11 tggttattta ttttgagtcc tagtcagttt yctatcagtc acatttgcca cttagcctta 60 a 61 <210> SEQ ID NO 12 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 12 actcatttga actcattaag tcttgatgat sagtaggttt ttgtctggca gagaaggggt 60 g 61 <210> SEQ ID NO 13 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 13 gaaatttcta caaagaaagt aggctctatc rttttctcgt tgatgtgctt cccatttcaa 60 c 61 <210> SEQ ID NO 14 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 14 aagtcaaagg taagagaggt ctctcagatt rcaacttagg tctccttgat ttcagacatg 60 c 61 <210> SEQ ID NO 15 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 15 gaaaggaaaa ggtacagtgt gtaagcaccc rtcacattta ccaccatcga gtgtctgctg 60 t 61 <210> SEQ ID NO 16 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 16 tgactaggga ggcagagcta cagagatttc rtgaatggac atcactgagg tagcgtacca 60 a 61 <210> SEQ ID NO 17 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 17 gggtcatgag aaataagcct ctggaggctg rcgcttctct actgtgggac cttggctgca 60 t 61 <210> SEQ ID NO 18 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 18 cattggattt caaagcttgc tttttctgtt sgttcttctc tctccttctc tctctgtctc 60 t 61 <210> SEQ ID NO 19 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 19 gcatagtgaa agccgctcac cactggctta rgaaactccc gggaggcagt tgcaaagctt 60 t 61 <210> SEQ ID NO 20 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 20 atgcagggtg ggcataggag aatttacaag scctttacct ctaagcctct gcagtttgtt 60 t 61 <210> SEQ ID NO 21 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 21 ctgaggtatt ctcaagttct agaaccacgg ycttaatgat tacccttgaa aagtcactat 60 a 61 <210> SEQ ID NO 22 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 22 cacctggctg tcagggatgg ggagcctcat sggtgaaaga gggttgtgat ggcataattt 60 a 61 <210> SEQ ID NO 23 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 23 aattcacagg catattcttg agggaacata raagtaacca gtaacgctgc tagtggcaat 60 c 61 <210> SEQ ID NO 24 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 24 tctaaaataa cttgctttat gtttgagaaa mgattgttca gtagtctgta agtagacttg 60 t 61 <210> SEQ ID NO 25 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 25 taatactaga tgactcttta tcctcatcaa raggcttaga cttcagtcct ttaccacctg 60 c 61 <210> SEQ ID NO 26 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 26 gactcgctgg ggaaagatgc tcctgctggg yggggaacaa cccctgccag ccccacgctg 60 a 61 <210> SEQ ID NO 27 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 27 gggcagaatt ctggcagttc tctgtggtct ygtttttaca aatagaacca gggacagggg 60 t 61 <210> SEQ ID NO 28 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 28 atttaagtct agtgaatagg gagttgctat ytgaaaaata tcaaattttt cctttatgaa 60 a 61 <210> SEQ ID NO 29 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 29 caatcagcta ttgacccaaa gctcacagct ratggacttg ccaatgggcc taataatgaa 60 a 61 <210> SEQ ID NO 30 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 30 caatgtcctc cagaacctga aatttgaatt yggttttttg gcatcataag tggcttctat 60 g 61 <210> SEQ ID NO 31 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 31 agattgtagg ctttggtgtc agacatttga yattagaatt ctggcttttt taccagcccc 60 t 61 <210> SEQ ID NO 32 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 32 tatgtaagtg ggatcctaca gaaagctatt rcttgtggtt gactactctt gctcaccatg 60 t 61 <210> SEQ ID NO 33 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 33 gatcattttt cattcttaca acaggattta wagctttcat gggctctatc ccttgcttat 60 t 61 <210> SEQ ID NO 34 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 34 gacagaggca ggtttacctc gagactgaaa rttaagactc ctcatttgta tgggtcttct 60 t 61 <210> SEQ ID NO 35 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 35 ttgccattgt cccttataaa gaatggcatc yataatttga caaaacattc agaacatagt 60 g 61 <210> SEQ ID NO 36 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 36 gaggaaataa tttgcccagg taactaagga rtgatggttc caggaatggc tataatatac 60 t 61 <210> SEQ ID NO 37 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 37 ccagtcaaat tatattatag gcccatccta ygcaagtata acataaccac atcttaacta 60 a 61 <210> SEQ ID NO 38 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 38 agtggcaagt gcagagtaat tcttcctaaa rggtgagaag agagaaagga aattattttg 60 c 61 <210> SEQ ID NO 39 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 39 atcaattctc agaccaccag tgctgtaaaa kactactcca ctcttctttt taaaatccca 60 a 61 <210> SEQ ID NO 40 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 40 agttttctgt tgttatcatc gctgctcaac kctaacagaa gctcctgtgt tggtgtttgt 60 t 61 <210> SEQ ID NO 41 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 41 accagagact gaagaacact tttggaagca yaaaatctgt gattattatc tagctttcca 60 g 61 <210> SEQ ID NO 42 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 42 ctacctttgc agctagagct aaatgatccc ycaggaatgt ttccaggtca tgaaggaaca 60 t 61 <210> SEQ ID NO 43 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 43 agaagaccaa aaagcttgga ggattgtgca rttttagaga ataaaacatc aatatgacct 60 a 61 <210> SEQ ID NO 44 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 44 cttttaattg ttgatgtcat catcaaggaa katagtggag tcttaactgt tttccccaaa 60 a 61 <210> SEQ ID NO 45 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 45 tcgtaaaaag gatactgagc aacacaagaa ygattcctaa ccttagggag cttaaagtct 60 t 61 <210> SEQ ID NO 46 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 46 cctttaaatg gaagagttca atcactcatt yggttcgtat gcagtttttc cttatttcac 60 t 61 <210> SEQ ID NO 47 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 47 tactgcttac agagtatttc tagaccacga yttagggaga gaaatcccag atggagctca 60 g 61 <210> SEQ ID NO 48 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 48 atccatagtc tttcattctt cctagattca rtaattcctt tgcttgtcta tttagttttc 60 t 61 <210> SEQ ID NO 49 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 49 aatcagggtg aaaaccagca gcctagttac ygctagagga tcagaatggg agtggagctg 60 t 61 <210> SEQ ID NO 50 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 50 atagagcact gttataaatg cctccttgct ygtccgtatt ccccaataga ctctaagctt 60 t 61 <210> SEQ ID NO 51 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 51 caggtcatca gcagatattg agttgccagg mgagcataat tagagaaaag acattcagat 60 c 61 <210> SEQ ID NO 52 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 52 aaggagtaag aagcatgtat agttcacctc mttagtaata aaccttctta aaacagggag 60 a 61 <210> SEQ ID NO 53 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 53 tatgtttgca tctgtctaca atatgacttg rgccaaatct gatctggcca tggcatcctg 60 a 61 <210> SEQ ID NO 54 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 54 gggggagatt aatgtttctc acaatgccat rtaccaaaca cagagttgac ttttcagtac 60 c 61 <210> SEQ ID NO 55 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 55 gaatatggat aagatcctag aagcagcccc rgatatgtat ccacagtaga agcttaatgt 60 a 61 <210> SEQ ID NO 56 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 56 tctgtacagt agcttttgtc cagcttcttc rttagtttta gtgggatttc tctgagcagc 60 g 61 <210> SEQ ID NO 57 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 57 catttaatcc tcacaaggac cctgtgacag maagtactgt tgtatatgaa gaagctgagg 60 c 61 <210> SEQ ID NO 58 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 58 ctgtatcccc ttccctgccc tatgccttga wgagttaagc gtaagagccc ttgttcagcc 60 t 61 <210> SEQ ID NO 59 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 59 ctcatctcct caactgccct tcattcactt kttttaatca cataaatcaa tgtttgaact 60 a 61 <210> SEQ ID NO 60 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 60 tctttctcct aacctgaata cgtcatatta mcatttcaat actctttcct tcattaggtg 60 c 61 <210> SEQ ID NO 61 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 61 gacctggtct agaaattgga gaagttccag ygggagatcc tcttccacga ggaaatggct 60 c 61 <210> SEQ ID NO 62 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 62 aaagaaaccc ctacggaatc aatccctcac rtacttttta tttgcaaaaa ggcaactgag 60 t 61 <210> SEQ ID NO 63 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 63 ctcaataaat gtgcattgat ttttgactgg wtttccttat ttaggctaat aatattgatg 60 t 61 <210> SEQ ID NO 64 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 64 attcagattt agttgatcca agctctaggt sagatttctg tagttctctt tgccctgttc 60 t 61 <210> SEQ ID NO 65 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 65 aagatttcaa gtgtttggta ctggaggctc ycagagggca gaacagtatc tgttttgttc 60 a 61 <210> SEQ ID NO 66 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 66 acctggctga aaactagcat ttaaccagta wctagtaact ctgtgcgagc tattggaggc 60 a 61 <210> SEQ ID NO 67 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 67 gagaaatgta attacagagc acttataaaa yctttcagta ctttagcaac cacaacttat 60 t 61 <210> SEQ ID NO 68 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 68 aagtcatgtt atcttttccg cttaacacat ktatcctggc ttgaattaaa tgtctgtaaa 60 t 61 <210> SEQ ID NO 69 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 69 ctcattctcc catcacacca tcggtctctg raaaaaaatg gtcccttcca cgactatatt 60 c 61 <210> SEQ ID NO 70 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 70 ataaattaga tctgcaaaca cactttagct wtgctgatga aaataattta gaataaagaa 60 g 61 <210> SEQ ID NO 71 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 71 ccttcagtca ttttgcaaac ctcaatgttc ygaattatga gctaactgtt ttggaagtga 60 a 61 <210> SEQ ID NO 72 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 72 gatgtgagct catcaagaat gctcagggga mgtttcttct tggaaggtcc agttaagctg 60 a 61 <210> SEQ ID NO 73 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 73 gagcaaatat gcttcactct taacaaacac wtacttcaca acattcccac tgacagaagc 60 t 61 <210> SEQ ID NO 74 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 74 agtccacact gaatgaagat ggtgaatact raggtttccc acccactctt ggaactggct 60 a 61 <210> SEQ ID NO 75 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 75 ttatgtctat ctatagacag atatcctgtg racttcgttt gtattttgta tccacaaaag 60 c 61 <210> SEQ ID NO 76 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 76 tggaactcct ttgataattt ttggctggat rtgcacgtac acatttacct tcagtcacac 60 a 61 <210> SEQ ID NO 77 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 77 aagaaaaaaa actagcgtat taagtacatt ygccaaacct ccttttcttg acagatggtc 60 a 61 <210> SEQ ID NO 78 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 78 cagccacaga gtggggcttg cagattttgg raagaagagt gagtgcagtg ctctgggcag 60 a 61 <210> SEQ ID NO 79 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 79 ctacaggaca ggcaaaggag tattttgttg saggataaga tgcttgatat tatgaaacat 60 a 61 <210> SEQ ID NO 80 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 80 acgaggctta aaaataatat tgcagtcatc kctggcagtc tgaaagctgt gtacataccc 60 a 61 <210> SEQ ID NO 81 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 81 actttcagaa ggaccaacca cgaaaaccac yctgatcttt tttgttgtcg ttgtttgttt 60 g 61 <210> SEQ ID NO 82 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 82 tatagtaggg ggaattcagg tttatagatg ragtctgcct agttctttat ctccataggg 60 c 61 <210> SEQ ID NO 83 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 83 atgaatatgg tagcaagtgt cttccttcct ktgaaatatg agttttcatc agctgttgga 60 t 61 <210> SEQ ID NO 84 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 84 aacaaatgtg tggtctcatg gtttgaaaaa ytgtgaatca aatcatattg catatgaggt 60 c 61 <210> SEQ ID NO 85 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 85 taagtgatat ttaccaaaaa caggcttgct yagtttggaa gattgtaaag aggaaactct 60 t 61 <210> SEQ ID NO 86 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 86 gactgatgac gttgtcactt tggagtagct kgtccgatgc acatcaggta agcaagtgca 60 t 61 <210> SEQ ID NO 87 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 87 atataatatc tcttgacacc ctttccactt rttgccaccc tattttcctt cttcccttta 60 t 61 <210> SEQ ID NO 88 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 88 catcctacct actcaatcaa accttttagc rccagcctga gaaacagaaa acatgtggag 60 g 61 <210> SEQ ID NO 89 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 89 tattcatctt tgcgtccacc acgatattta stagattgtc tgcctcataa taggcattca 60 g 61 <210> SEQ ID NO 90 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 90 tattgaactt gagacatgta attggggttt ygtaactagc tactcactat atagctattg 60 g 61 <210> SEQ ID NO 91 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 91 tgattttttt caatccacag gaccagaaca mggcctggta tatagtaggt catcattaaa 60 g 61 <210> SEQ ID NO 92 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 92 cagaatttca tcctggctaa caaactcata scaaattagg ctctctgaca ttggattatt 60 t 61 <210> SEQ ID NO 93 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 93 ctaaaacctg ctgtgggcgt cacacttctc ygggagcatc attgggcagc tcagccggcc 60 a 61 <210> SEQ ID NO 94 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 94 atcttgacaa atttcctaaa gagaaggact yaggactgtt tcttataggg tggctggatt 60 t 61 <210> SEQ ID NO 95 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 95 tatgcttcat catattagcc tttacctctc yagacaaagt tcatccacct atttggtaag 60 t 61 <210> SEQ ID NO 96 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 96 cttgcattcg aatgttccca ttttataggc ragaatacca acaaacagaa gttaagaact 60 t 61 <210> SEQ ID NO 97 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 97 ttgaaccctg cattttccac tataactagc rtctaataaa aaccaaccaa gaatatttag 60 t 61 <210> SEQ ID NO 98 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 98 ctttctgtca acttgatata tactgagctt yccattaata aaaaagaaac taagacgttt 60 c 61 <210> SEQ ID NO 99 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 99 agacagtaca agttccatag ctggtcaccc rcattcacac cccagcagtt ctacaccctt 60 g 61 <210> SEQ ID NO 100 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 100 catacaagtg gaaaagaata acattttgat wtttaaagtc aacttttgat agactttatt 60 a 61 <210> SEQ ID NO 101 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 101 ggaatattgg tttttttgac caatttcaaa rtgccgtatc aatgctgttc ttttctttta 60 a 61 <210> SEQ ID NO 102 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 102 caggaaatgt agctaaatga atgaatgagg ycaactctat cacatgatgc ttctagtaac 60 a 61 <210> SEQ ID NO 103 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 103 gtttaggtag atgtcataca tttggatgaa kaagttccct tctattccta gatgaaagtt 60 g 61 <210> SEQ ID NO 104 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 104 attcatgaag ctacaaatca tgactagatt wctggtccca actctgccac tttatggcct 60 g 61 <210> SEQ ID NO 105 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 105 tggtttttcc tgtggctcgg gcctcagctt ygtatcacct ctgcagagag gctctccgtg 60 g 61 <210> SEQ ID NO 106 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 106 gccaggagca ggtctggggc ccaccttctg ygttgcgtag accaggcttt ggtcggctgt 60 g 61 <210> SEQ ID NO 107 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 107 acccaaaagt gactgggctg actgccaaga katggcttta aaccagaaga aatggagatg 60 t 61 <210> SEQ ID NO 108 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 108 gaccagagga cactggcttg tagaacgatg yggaaatgga gacagacact tcgaaaggtg 60 a 61 <210> SEQ ID NO 109 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 109 tctcttagca aagatctcaa atcgctgcac magaacacaa gcaacagctc aaaggctgag 60 t 61 <210> SEQ ID NO 110 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 110 cagggaatag tccattaggg aaagtgttgg ytgggggctt tatatatggt catatgctac 60 t 61 <210> SEQ ID NO 111 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 111 accttggata tagcaggaat atttgtggac ygagtgagga aatgaataga gatggttcct 60 a 61 <210> SEQ ID NO 112 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 112 gttatatctc tgattcattc aaattggaag ytttgggaat cttgctgtta ttgttgtcaa 60 c 61 <210> SEQ ID NO 113 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 113 ttagtccagg tgagcaaatt accctgaata rgtgtgtagg ctccctccct gccaccgagg 60 g 61 <210> SEQ ID NO 114 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 114 atactcagcc gagatacccc cgatttgtta ygggatggca aaaagatatt taaggctatt 60 c 61 <210> SEQ ID NO 115 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 115 aactgttttc aggttgcaac agacaaggca raaaaccttt agcagtgaaa ctgaaaagat 60 t 61 <210> SEQ ID NO 116 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 116 ttgatttatt agaaggattt ggcatcagga rcataaaaat ggttaatggg tgctgtaact 60 t 61 <210> SEQ ID NO 117 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 117 aaaagtttat tcagttttaa tttctggcta sagcttcttt gctaagaata acaaatactc 60 a 61 <210> SEQ ID NO 118 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 118 tcacacattg cactcagatc tagcctctta ygttttaacc ttagtctccc ccttaaatct 60 c 61 <210> SEQ ID NO 119 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 119 ccctaatagc aggccttgaa tagtgcaaaa yagtcttctt aaatacatta gtctttcttg 60 t 61 <210> SEQ ID NO 120 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 120 aaacaacgag ttatgcctct catggaactc rgagaggaaa gcaaactggg agactaactg 60 a 61 <210> SEQ ID NO 121 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 121 tgtaaacaca ttctttattg atatgcacat mgtgattctg atttggaata ttaagggtcc 60 c 61 <210> SEQ ID NO 122 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 122 ttctggaaag aagattaaaa atgtcaaaaa mggtgctaga ctgtgaagat gatatcccct 60 a 61 <210> SEQ ID NO 123 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 123 tacaaaataa agataacaag agtacctgtc wgatacagtt ataacaaaag gcaaatgagt 60 t 61 <210> SEQ ID NO 124 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 124 atatatgaag ttgggggaca cagacattcc raaaatagcc agactctcat ttatctaaaa 60 t 61 <210> SEQ ID NO 125 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 125 tgagcacttt actgtgaggc aggtactacc rtttccattg tacagatggg ataatgaagg 60 c 61 <210> SEQ ID NO 126 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 126 ataaagcgaa gcaattcctg caaatattca rgtattcacc ttttgagaaa ccttaaaagg 60 a 61 <210> SEQ ID NO 127 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 127 cagtcagggt ccccatcaca cagccagctc ygggagacac aagtcacgtg atcgtggcaa 60 a 61 <210> SEQ ID NO 128 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 128 gaaaatttgg tgtttttcac tgaagccttt kttatatttt tgacatataa taattgcata 60 t 61 <210> SEQ ID NO 129 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 129 tattttcttt tttaaactaa tgccatagtt yaattattta agccagacag ctaaaactgc 60 t 61 <210> SEQ ID NO 130 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 130 cattcccgtc tatttggttg tagataaaag rgataagggg cctctttctc aataactact 60 t 61 <210> SEQ ID NO 131 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 131 attacatttc ttatcaagta agaataaaca wctcatcatc aagtaaagta atgtgacttt 60 t 61 <210> SEQ ID NO 132 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 132 tttttcaacg tggtaccaca aatgtggcca saaggatttt cataatggga tattgtacat 60 a 61 <210> SEQ ID NO 133 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 133 aattacctct gccatggata cttgcaatag stagcaaact ggtctccctg gttcaactcc 60 t 61 <210> SEQ ID NO 134 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 134 tggcataggg actacgttcc aggagccagt rttccaagag gaccagaaag aagttgtata 60 a 61 <210> SEQ ID NO 135 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 135 caataactta aatacatcag cagagaaaac rttatgaggc ataaggacca tgtggttctg 60 g 61 <210> SEQ ID NO 136 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 136 aattttagga attagtgaga gttacatctt watccatttt tactttagaa cttatttttt 60 t 61 <210> SEQ ID NO 137 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 137 tctcatattt gagatagaat acctatagtc yatcctggag gggaagaaag catgcaaaaa 60 t 61 <210> SEQ ID NO 138 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 138 ttatctacag acaagtacac ccccccagtt kaaaaattaa gagcaataaa agtctaagtt 60 g 61 <210> SEQ ID NO 139 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 139 tcctagtgca gaacacagat cctctgtggg yaaaactagg tatattgttc aatggcccca 60 t 61 <210> SEQ ID NO 140 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 140 acaggtgtct ctgtaattgt gatacgttgg kaaaattcac actgttaaat gagcctcaaa 60 t 61 <210> SEQ ID NO 141 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 141 tctccataat atttgtttaa attgaccaca yggttagaaa tgagaaatct aagatttttg 60 t 61 <210> SEQ ID NO 142 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 142 aaatatgttt atgtgtatgt gtaccttttt yctacatttc ttctgttaga gtttaaggac 60 t 61 <210> SEQ ID NO 143 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 143 gtggtggcct cataccatag tagctgctta sttaattatg actaatataa ggaggtatag 60 g 61 <210> SEQ ID NO 144 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 144 aaatatagca gctacaatct aatttcattg raagtctcct ccaaatcaca gaagtgccac 60 t 61 <210> SEQ ID NO 145 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 145 aacttattat ttgttggagt ttgaaactta stgaaggttt aatcaggtac catatgttgt 60 t 61 <210> SEQ ID NO 146 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 146 ataggtggct gtgttagcag actgaagtct stggtccagg attggagcct gatcattttt 60 a 61 <210> SEQ ID NO 147 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 147 ctaaagcaga gaaagaacat cccagtgaaa mtcaatgggg aagtcacaac cacagcgaat 60 c 61 <210> SEQ ID NO 148 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 148 agtatgtcct ccatcccaat tacacctggc kttataaaat gaatgtacat tttctatttg 60 c 61 <210> SEQ ID NO 149 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 149 aacaatggca gtgtaacatt tcacagtaat mcagctggcc caaaatttta aagatttaat 60 a 61 <210> SEQ ID NO 150 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 150 gacatcttta aggagtcatt tttctgctta ytacaaaagg taaattttaa aaagcaagta 60 c 61 <210> SEQ ID NO 151 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 151 tatagacaac atagtctgta tcaaattgcc rgaaattaac atggtgaaaa ttattctatg 60 c 61 <210> SEQ ID NO 152 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 152 aatggcattc cttttagaca agttgtaaag ktcaggaaag tataaagaga aaaattcctg 60 a 61 <210> SEQ ID NO 153 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 153 aatagtgaca aaccaatgat caccaatggc yactaaaatc atcagctgga aaggtagtga 60 g 61 <210> SEQ ID NO 154 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 154 aagagactag taacagtagc ttgtgtatac ktgtgataaa atgagcccta cctgaaagaa 60 g 61 <210> SEQ ID NO 155 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 155 ttacattaag gagactgtct gtcacttaca yaaatcgttg atgtcttcat actcagcctt 60 c 61 <210> SEQ ID NO 156 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 156 actggtgagg gttaggagaa aaattgcatg sggaaatcag ggtatttctc tggctctatt 60 t 61 <210> SEQ ID NO 157 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 157 caggcgcatg gcctttctgc ctcaacttcc rtttctctaa ggttgccgta agaataaatt 60 a 61 <210> SEQ ID NO 158 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 158 tggtttcagc aaccatctgt tttggtctca rtgtgaaagg caggcaaaac tatgctgaca 60 a 61 <210> SEQ ID NO 159 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 159 acctgagctt cgttcccagg atgtgctgct sactggccat gcaacctggg gtatcctata 60 t 61 <210> SEQ ID NO 160 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 160 tgtttttatt tatagtactc aaggtcagtt rtagtgcatt cacactattc attgaccctg 60 t 61 <210> SEQ ID NO 161 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 161 gtgatttgaa ttcattttgt ccagcagata ytagtgagaa gctcggccac tgcttcatgg 60 c 61 <210> SEQ ID NO 162 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 162 aaaaacaaac ttctctatgc catagttctg mtttacagat ggaccaggca tgagcgcttg 60 c 61 <210> SEQ ID NO 163 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 163 ccccagtcca taggtttgaa attgcttcta ytccatctac ccacagagct agtgctgggc 60 t 61 <210> SEQ ID NO 164 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 164 ataaatcata aatcgaaagc atatagagaa yatgaggaag catgaaaagt cattacgctg 60 a 61 <210> SEQ ID NO 165 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 165 atataagtag cctatataac cactttgttt sactaaaaac tatgtttctt tgatgcaaat 60 a 61 <210> SEQ ID NO 166 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 166 ggctcagcac ttggcctcaa gttaaatgag yggtctttca tgtgacgtct caatgggaac 60 a 61 <210> SEQ ID NO 167 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 167 cttgaaaaca gaataaatgt acttagctca yagaggtaat gtgattccaa tttagctggt 60 c 61 <210> SEQ ID NO 168 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 168 atgtggaatg tttagtcatt agtgttatta rgaaatcata gttatttaat ttatgtttta 60 a 61 <210> SEQ ID NO 169 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 169 aagatcagga acaagacaag gatatcgact rttaccactt ctttttgaca tagtactaga 60 a 61 <210> SEQ ID NO 170 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 170 gtgaagtgat ggttatgtta attagcgtga ytgaaaattt ctacaatgtt tatgtagatc 60 a 61 <210> SEQ ID NO 171 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 171 ctatgttaac ttggcagcat gagaacctcc rtacacaacc tgacaagaaa gacatgcatg 60 t 61 <210> SEQ ID NO 172 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 172 tacatcattc cttatgtaca atactttatc matgccattt ttatgatgtt gtatactagg 60 t 61 <210> SEQ ID NO 173 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 173 ttttcacatc aatatcagca gtttaccttt ytacatggca gtgttatatt gaagaaacac 60 t 61 <210> SEQ ID NO 174 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 174 taaaaacttt taagtgattt ttgggtctgc rtacacatga gagttaatta ttagcaggaa 60 a 61 <210> SEQ ID NO 175 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 175 tctctttaag gtctacctct acctcctctc ytggccacct gatgcataaa tagagacaac 60 t 61 <210> SEQ ID NO 176 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 176 ggaacctagg aactaaaaac acatgttatc rtcccacaca aatccaacat acaataatga 60 g 61 <210> SEQ ID NO 177 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 177 tatctgtgaa atagagctta agggttaata ygatgatgag caaacatctg gaattctctt 60 c 61 <210> SEQ ID NO 178 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 178 aggtcacaga aattcttatt ccttgttttc yctgagttat gacatagtga aatgttcctg 60 t 61 <210> SEQ ID NO 179 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 179 ttaatacaat taatgtctcc tcgagttttc rtgcagatca acacacctac tgacagtaat 60 g 61 <210> SEQ ID NO 180 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 180 aaatcagcca aagatagagc aaataataat rgttgaaaag tagtgtaaaa aatacctttt 60 a 61 <210> SEQ ID NO 181 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 181 ccagtggagt caataaagca taaagtcaag rgtttctaaa cacgacctgg gtgcagatgg 60 c 61 <210> SEQ ID NO 182 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE:82 tactcacggc atcgaatttt ctatcaaaaa ncatttcaga agtcaaaagg tttttaaagt 60 t 61 <210> SEQ ID NO 183 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 183 atgttgcctt attgtgagaa aggctaaaac mgaaccagta agtcctatat ggtgaagtaa 60 g 61 <210> SEQ ID NO 184 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 184 aggcaatcag atgttcagca aataacagtt ytaatccttt ctaatccaga tttttctttc 60 t 61 <210> SEQ ID NO 185 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 185 tcctttcccc atccatggtc aataaccttc racagctgat ctaaaaaggt cgcctattct 60 a 61 <210> SEQ ID NO 186 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 186 gcttgctaat acgacttaag agactctaca yagccttatc ccagttatta cagacctcct 60 c 61 <210> SEQ ID NO 187 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 187 ccatccgatt cttgataggt tttattgagc ractttataa cgtaaaactg cttttagaga 60 g 61 <210> SEQ ID NO 188 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 188 taatacctat tgaactatcc tactaaatga yattttgatg accgtcaagg atgaagtggg 60 c 61 <210> SEQ ID NO 189 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 189 gaactagtat aatatgttag agaacccgat wagagctagg taaccctgat gactagttgg 60 g 61 <210> SEQ ID NO 190 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 190 tcagaaatgt acattcaaaa caatcgaggt wggctttaaa ggagcattca aaatcattaa 60 c 61 <210> SEQ ID NO 191 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 191 atgaccagag agttgcatta gctcagtggt yctcaaattt ggctcatctt taaaatcacc 60 t 61 <210> SEQ ID NO 192 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 192 ataggagttt cagaacccga ctacacatct stcgttgatg gtctaaatat ttgcatgttt 60 g 61 <210> SEQ ID NO 193 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 193 aaagaaatag aaaaaaaaag ataacacaaa wgctgagaca ttaatttctt caggtcctga 60 c 61 <210> SEQ ID NO 194 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 194 cctggctgca gctatgcaga ctatacagaa ytgtgaactt ctttcctgac ctttggatat 60 a 61 <210> SEQ ID NO 195 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 195 tccatgtaat tgtttaaaaa atgaaaattc maagaactaa ggctgaacag gcgtagaaat 60 c 61 <210> SEQ ID NO 196 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 196 gatccaaaca tagtcactct aatgcacatg sacaataggc aaggcaggga cttatatcta 60 t 61 <210> SEQ ID NO 197 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 197 caaagataag ttaagcaaaa ggaacaacta rtatgcaaag aaaggcaaaa tacagagatg 60 a 61 <210> SEQ ID NO 198 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 198 tatatcagaa acctgatttg ataaacaaac raaagaggaa tttctctgat ggaattggct 60 g 61 <210> SEQ ID NO 199 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 199 aataaagcaa agttaaagcg atggaaacct ygagagaatt gcttggtgtt tgtaagagtc 60 a 61 <210> SEQ ID NO 200 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 200 ctttctccca ccactaatgt ctctattcgc ytagttatgt cattatgaga ttcatggata 60 t 61 <210> SEQ ID NO 201 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 201 gcagcctagg agaggaaaat agcttgttta yggagctggt aaagagaaag tagaggaatt 60 c 61 <210> SEQ ID NO 202 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 202 tcctccctac agaaccaaga agattcatac rtgactggaa cctgaatgca gaaactcttt 60 c 61 <210> SEQ ID NO 203 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 203 aggatggttt gtccatctag gaaatgaagc ycctagtcca acagtcttcc aaaaactgaa 60 t 61 <210> SEQ ID NO 204 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 204 cacctcccat gtgacctgat gctggagaaa stgtggttta gcgggaggct gatggggaag 60 t 61 <210> SEQ ID NO 205 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 205 attgcaaatg aggagaagca ttctagtgat rggcttggat tctcatgacc aacgatggta 60 c 61 <210> SEQ ID NO 206 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 206 tctcagagaa tatttaatta gcaacatgac maaaattagt tgatttattt gaaggatatt 60 t 61 <210> SEQ ID NO 207 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 207 tgcttaaatg tttaaataag cttcttgaaa wctcatggaa cattcaatca caactccaac 60 a 61 <210> SEQ ID NO 208 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 208 accttttcct gtcctcctgt ctctcgggcc yattccccac tgaggctagc catagaagct 60 a 61 <210> SEQ ID NO 209 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 209 gtttaagctt tagactcttc agttataggc ytgatgaaga acccaagtca tagattcaca 60 t 61 <210> SEQ ID NO 210 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 210 ttataatgaa taaccatttc ctaatttaat raaaccctat gccttaactg caaatgttaa 60 t 61 <210> SEQ ID NO 211 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 211 tttattttgc tcaaatttca tctctggaga rgtctttccc aaccaattac ttcaaagaaa 60 g 61 <210> SEQ ID NO 212 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 212 atgaatgctt tcctagaatc ttccttctgg ratcctactt tttatgtagt ttggagattc 60 t 61 <210> SEQ ID NO 213 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 213 gccagtgtaa gtggtgcgcc attgttgagc yatcattgaa tctattttaa tttactaaaa 60 a 61 <210> SEQ ID NO 214 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 214 ggtgacatgg gggaagtgat gcaaaccaac rtgaaactca tgagtaacga agtcctttgt 60 c 61 <210> SEQ ID NO 215 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 215 gtgagaagtg ggcatgtcag gccaaaaaac yatgtggaaa agcacaggaa tatgaaagca 60 a 61 <210> SEQ ID NO 216 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 216 gctgacctaa gtgactttgg aaatgggtag sattgataag actaaatgca aaataagtgg 60 t 61 <210> SEQ ID NO 217 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 217 agtacggttc ccagtccaag gctggaagaa ygaatgaatt aaaaatgcta ataataacag 60 c 61 <210> SEQ ID NO 218 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 218 ctgcttctta atggatggta gacagtgaaa ytcatatcta taaaaataac cctctgcagt 60 c 61 <210> SEQ ID NO 219 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 219 ccagggaggc tgaataaaac cagagagatg ktagcattag caacaaaatg aaactcccct 60 c 61 <210> SEQ ID NO 220 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 220 ctcttacttc ttggggattt tgtcctcttc rgcatcggtg ctgtctgtgg cgaatgcttt 60 g 61 <210> SEQ ID NO 221 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 221 acccacacac gtgtatacac acagtgcaca matggctgac tgctgaccag aggaaccaga 60 g 61 <210> SEQ ID NO 222 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 222 ctgccatcca gagagaacag agtttggacc rtgtccgcag aaggccttgg agtgttgacg 60 t 61 <210> SEQ ID NO 223 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 223 gaggcttggg acctgaaggc ccattttccc mcagtgatgt tgcgaggtag gtgtttaggg 60 t 61 <210> SEQ ID NO 224 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 224 acttctatcc ctccttcctg gcactccata rtcactttac tatgctttgt cttttgctgt 60 g 61 <210> SEQ ID NO 225 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 225 tagacggaca caacagatac tcctttctcc stgctgtgca gcctggagag tgtccccaga 60 g 61 <210> SEQ ID NO 226 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 226 atgtttggtt gggggtgtca ccaaagtaac rgtccattat tcaaactggc agacatttga 60 c 61 <210> SEQ ID NO 227 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 227 ccaggaagaa atggccatta gctgaaatga ragagtgtca gggctagaaa caaggatgtg 60 g 61 <210> SEQ ID NO 228 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 228 ttattgatct caatgtccta agcatgttaa rtctatgaac tcaatcaagt ccccacacca 60 a 61 <210> SEQ ID NO 229 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 229 ctctagtctc tggggacccc tggggggaag ragtctaccc tgcttgtgag tcccgtctca 60 g 61 <210> SEQ ID NO 230 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 230 tccctctaaa acagggccct gaaatccaga ygcgatcagc ctagtggtat cactgcccca 60 g 61 <210> SEQ ID NO 231 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 231 tggatatgtt tattatattg tgatggcttc wtgatgtatg tatatgtcaa aatgtatcaa 60 a 61 <210> SEQ ID NO 232 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 232 agtgaagttg gcacagtggg cagttaataa kgtcggctct gaatcaggaa aacctgggtc 60 c 61 <210> SEQ ID NO 233 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 233 gggtcctgag gggctcttaa cttctagttc yttcctattt cagtttatcc atgtggaact 60 g 61 <210> SEQ ID NO 234 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 234 atttaggatt agggacttgg aaatagattg mgactggata tagctttagt gttaacatgc 60 t 61 <210> SEQ ID NO 235 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 235 actagatttg agtcttgccc ctgcctgact rtgacatgag caagttaata tacctcttag 60 a 61 <210> SEQ ID NO 236 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 236 gctcaaatac aatttccagc atgaattgag yggtggaaat cggatctgac cacaacactg 60 c 61 <210> SEQ ID NO 237 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 237 cccagttaat tccccacatg aaaataccta yatgttggtg gaaaagtgta atgttcaaga 60 a 61 <210> SEQ ID NO 238 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 238 tccaggtgca aataaatgcc agggacagct yacctgggcc agtattttta tttgagttct 60 t 61 <210> SEQ ID NO 239 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 239 gccagccctc ctaggccacc tctgcataat rgatgatttc acaagcggtg tgcttgagat 60 c 61 <210> SEQ ID NO 240 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 240 tccctgttca tcacagtcag tatgggttta kaagcacctt tttctatttc aaaataccag 60 c 61 <210> SEQ ID NO 241 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 241 agatacatat aaataccaag taatgcaaac rgttcagtga tttcttccag agaaacagga 60 a 61 <210> SEQ ID NO 242 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 242 ttctaccctg aagcccccca tcatgcctca sagacctcgg ttcattcctg acgatcactt 60 c 61 <210> SEQ ID NO 243 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 243 gatcttgttc agccaaagcc tcataagttc ycctttcggc gcttgtcaga gaatgcagtt 60 a 61 <210> SEQ ID NO 244 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 244 tccagcaaag gaatgctctg atgtattttg yaatatattt tgacttcaga caagatacgg 60 g 61 <210> SEQ ID NO 245 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 245 ttcaaaaata tttttaaaat agtgacaaat rattaaggtt aagtggtatg ttaaagcctg 60 a 61 <210> SEQ ID NO 246 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 246 ggttaaggcg ttggttctac aactccagaa raaaaatgag caatgcttta tggtgcagca 60 g 61 <210> SEQ ID NO 247 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 247 atgtagtgct gaatagggca tatgttaatt yacttgcaga cgaaacacta cagatgaaac 60 c 61 <210> SEQ ID NO 248 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 248 ttcagtcatg aagactggct tgccaaattt rtaccttctt caaatctccc agggataact 60 c 61 <210> SEQ ID NO 249 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 249 ctattattct tattagttga aaaggagtgg yttgttttgc agttcttgcc tgcctgttta 60 c 61 <210> SEQ ID NO 250 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 250 cccttctctg taacaggatt attcacagac staccttctt agatatgctg gggtatgaga 60 t 61 <210> SEQ ID NO 251 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 251 tatgctgggg tatgagatca tgtttggaag sgacaaaaag tagcttctat aatttataca 60 a 61 <210> SEQ ID NO 252 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 252 ctaggggaga aatgggggta tggctattgt sttaagtagt aaattatcat ttgatattta 60 a 61 <210> SEQ ID NO 253 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 253 tttttttttt accttgttta gtggtcaagc rttaaccacc atgttcttca gaagagaatt 60 c 61 <210> SEQ ID NO 254 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 254 tgttttttat ttttctgtcc atcagaatca yaatggcagt gaagcccatc ccttatttgg 60 t 61 <210> SEQ ID NO 255 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 255 cctgggttat gcctagggat cacagttatg mttaggattg gctcaaggag agttttatct 60 t 61 <210> SEQ ID NO 256 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 256 ttccttggct gtcagtgctg cccagattca saagaatatt gcccacattt cactgtattt 60 g 61 <210> SEQ ID NO 257 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 257 tatttacaaa ccacctaccg aatgaaaaat sttgcctaga ggtatgaata cttggctgaa 60 g 61 <210> SEQ ID NO 258 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 258 taccctggat tttcatttca taactctcaa sacgtaattt gaaacaaaga gtcaccatcc 60 a 61 <210> SEQ ID NO 259 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 259 taaaaattcc tttcagtagt ggaacgaaat ractttggag aaaaggaaaa tgattttgga 60 a 61 <210> SEQ ID NO 260 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 260 cgactctttg cactttaaaa aagatattag maaccacaga agaaaaaaaa aattttttta 60 a 61 <210> SEQ ID NO 261 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 261 tactgtgatg aacaatagcg aaaagctctg raagtgatta acaaagataa tgaggtgaca 60 g 61 <210> SEQ ID NO 262 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 262 aatatatggt ctggtttggg ccacaaattc ratataatac aaatctagta tattttgtag 60 c 61 <210> SEQ ID NO 263 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 263 tcttataaga aacattctgg ctacaaaaca kcttttcgta tacaaactta tgaaaaccct 60 a 61 <210> SEQ ID NO 264 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 264 acaaagttca cccagttaaa tggtacaact yaatagtttt ttgtgtattt acacaggtgt 60 g 61 <210> SEQ ID NO 265 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 265 caaatatttg aattacacaa ggcaccattt mggttacaag actggtagca tacagcatgt 60 t 61 <210> SEQ ID NO 266 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 266 aaagtaaaac ccttcaaaaa tatgcactta rtcattacaa tttcgtaatt ttctttaaca 60 c 61 <210> SEQ ID NO 267 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 267 ttcccaatag accatcaata tcttaggaca ragcaatctc ttatattcta tcctctttac 60 t 61 <210> SEQ ID NO 268 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 268 ggctcagcaa ttatcctagc atcatttacc raaaagttca tctttgtctc aatgatttga 60 c 61 <210> SEQ ID NO 269 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 269 ataagccatc tgcttagagt cacctgaaca ntgagaattt agagtcttca tgctcaggtt 60 t 61 <210> SEQ ID NO 270 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 270 ttttgcacac ttgccctcaa gttgtttcag waccctggag tgtaatttgt ctaagcttga 60 a 61 <210> SEQ ID NO 271 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 271 agtgaataaa ggcctgcatt gctattattt rccaagctga taacacattt tgtttgtttg 60 t 61 <210> SEQ ID NO 272 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 272 gacttgtcaa agtctcatgg gcagtgattg mgaactcctt agatttcagt ttctttgttg 60 a 61 <210> SEQ ID NO 273 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 273 tctttctatc ttcaaggaag ctcacagtct rttagagagg acaaacatgt aatataaata 60 g 61 <210> SEQ ID NO 274 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 274 agctgttcac tcctaagtca gacgttgaat staacctcag tgctgtttct agtcactaaa 60 c 61 <210> SEQ ID NO 275 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 275 aagtctaatg atactaatgg agataagtac maggctaatt acacatgttt acccaacgct 60 a 61 <210> SEQ ID NO 276 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 276 gcaatgatag agaaaaatcc aaaatgtgaa ygagccagct agctgtcacc tgcatgcagc 60 c 61 <210> SEQ ID NO 277 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 277 gcacatagcc cagctctctc tcatgcccac mgatacttta agcttctatt gacttaaagt 60 g 61 <210> SEQ ID NO 278 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 278 gcaggaataa ggcaaacaaa cacttcatgc ygagcaaaac atcccaaaca actttcagga 60 a 61 <210> SEQ ID NO 279 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 279 aaatgtttac cattttaact atttttaagc stgcaattca atggcattaa gtacgttcat 60 a 61 <210> SEQ ID NO 280 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 280 agatctcatt ttaatttaca ttttttctga ygactaatta tttgaacatg tcttcatagg 60 t 61 <210> SEQ ID NO 281 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 281 cactacagta acacagacac caatatcaaa sgttaaaccc acacagtggc cagttaattt 60 c 61 <210> SEQ ID NO 282 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 282 aaagctttaa taaagtttgc taagggactc yggggtgcta agttggaggg attctcatga 60 g 61 <210> SEQ ID NO 283 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 283 taatgcaaag ttcaatgttt ggccactaac mtagtgtttc tctaaatgac tttaattaat 60 t 61 <210> SEQ ID NO 284 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 284 aacacacatt ttcacaatac taaaataaat kccccagttg ggtgcagtag ttcatgcctg 60 t 61 <210> SEQ ID NO 285 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 285 gaagagacct tattttgctt gctcccgtaa wttcttcaac ttttccagtt cagatgtttg 60 t 61 <210> SEQ ID NO 286 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 286 agtatatacg gctgaagcag agttagatca ygtagtacct tgtaaattgg gttaagaatt 60 t 61 <210> SEQ ID NO 287 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 287 agcattgagt cctttagaaa acaggaagta kgcatctgaa ggtattgagt gagaaaaagg 60 t 61 <210> SEQ ID NO 288 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 288 gactaaaaca tcatcttggc ccttgaagaa sttaaaattg agtgacaaat ataaactacg 60 a 61 <210> SEQ ID NO 289 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 289 acttaaaatt gagtgacaaa tataaactac raacatctgt aaacaactaa gctcaaaata 60 c 61 <210> SEQ ID NO 290 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 290 tctgtaaaag ttctggcatg gtgaaagatc staactctag gaagctgaat aacttaccat 60 t 61 <210> SEQ ID NO 291 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 291 tcagaaaaat gccaaggctt actctctcct ktggttgaat tcattactaa cagagtgttt 60 a 61 <210> SEQ ID NO 292 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 292 gaatttaaag ccatgggacc agaagaaatt rtgtaaaatg caggaagaaa agaaagatgc 60 a 61 <210> SEQ ID NO 293 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 293 agcttgcaca tccacaagac cagcccaata yacagctaga gtgcaaactg aggaggccat 60 t 61 <210> SEQ ID NO 294 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 294 ataaataaat aaataaataa agagtgtata ygaggaaaat tatctggaag actatagtgg 60 c 61 <210> SEQ ID NO 295 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 295 attatgaaat gagttgtatt ggaactttcc ytgacagaaa tcctactcct ctagcttggg 60 a 61 <210> SEQ ID NO 296 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 296 catttgatac tagtaatcat tttatcttct rtgaaacacc ttttcccccc aggttttggg 60 a 61 <210> SEQ ID NO 297 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 297 taaaaagaaa ttttaatggg cttcagttcc raatgtggac tgtgataatg atttaccaga 60 g 61 <210> SEQ ID NO 298 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 298 gtcctgtatt tctcactagg agaatagtgg rattttgatt ttgttttata gggattgctt 60 t 61 <210> SEQ ID NO 299 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 299 aaaagtctgt gcattgcaat aactgctact rtcccaattt tatgccaaaa taaaccagct 60 c 61 <210> SEQ ID NO 300 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 300 ggaatagagg aataatggaa tctgtgataa yttgataagt caataaaaaa catttcaata 60 a 61 <210> SEQ ID NO 301 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 301 aatgattctg gatccaatgt ctgttagatt ktcaaggttc ctacaggaat acctctagaa 60 a 61 <210> SEQ ID NO 302 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 302 tgctacattg tacatttgtc attcaaagtc rttataacaa atgccattaa aggctagatt 60 g 61 <210> SEQ ID NO 303 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 303 ttcttattat gtaaatttat agctaactct yattctgaac tgtactttcc tgtacatgcc 60 c 61 <210> SEQ ID NO 304 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 304 ttcctaattc ataaatattg aatgtacagg ygggatgaca ttctcagtta ggagtcacct 60 t 61 <210> SEQ ID NO 305 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 305 acttgccagg ggtcttagtg gagactatgt raggagcttg aaataccatc atcctactct 60 g 61 <210> SEQ ID NO 306 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 306 agacacttct cttctcttct cagttgttat ytgtgtccac agaggatgca aaaggaaggt 60 a 61 <210> SEQ ID NO 307 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 307 cagatggaat gaaattgcca cctggatggg waactacaaa tgacaataca agctgggaag 60 g 61 <210> SEQ ID NO 308 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 308 gggtagggaa aagcacaggg cctgatagag staattggtt ccattaaaaa gagatgctag 60 t 61 <210> SEQ ID NO 309 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 309 cagtaaatga cacattatac atgagctcac yaataaccaa cattatccca ggcagtaatt 60 t 61 <210> SEQ ID NO 310 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 310 ctgtggatct gcagttagca tatcaaagtg sttcctgagt tggaggattc agaatagggc 60 t 61 <210> SEQ ID NO 311 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 311 gaattctgta tgaaatatgt taatcaacgt rgcctcttaa ggtgtctagt tttattaatt 60 a 61 <210> SEQ ID NO 312 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 312 attatcatcc tttctaagag aaatcctttc ygatcacatg atggtgggac aacagaaaag 60 t 61 <210> SEQ ID NO 313 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 313 catttcgagt ttggttcaca aaggcataca rcaagtttat tgtgtgtgtg tttattgata 60 c 61 <210> SEQ ID NO 314 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 314 gggacaggaa accaagagga cacagggggc sgtgtcgagg ttaacaggga gggctgcaag 60 c 61 <210> SEQ ID NO 315 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 315 tttactctta tttcatttac tctgctcaac watcctatga cacaaacatt gtcaatgtct 60 g 61 <210> SEQ ID NO 316 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 316 tcatggctgt gattgatggg atgtcttaag ytgcttcatt tttgccctac agtggatctc 60 t 61 <210> SEQ ID NO 317 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 317 aagttggatt gtagtgctgg atgtgaaccc ragtcagctt tctcatctgt aaaatgggga 60 a 61 <210> SEQ ID NO 318 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 318 cagagctcca gagctcacac tctgctctca raactagatt aagcagcgag aaggtgtttc 60 a 61 <210> SEQ ID NO 319 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 319 ccaggcagcc caagtggaag cattgtgaga rtcggtggtg gtgtgagcgt gtatgccctg 60 c 61 <210> SEQ ID NO 320 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 320 acatgtttct gaagctgagg agttggtttc yaacacgtga tctgacctga cctccactag 60 a 61 <210> SEQ ID NO 321 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 321 ttttttttta cctgaggtta ttttacttct stttgctctc cttctccaca taaaaaggaa 60 a 61 <210> SEQ ID NO 322 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 322 gaaaagaaaa tttggattca cagtcttcct ytctaaaaat ccaggctatg aagaaaaagc 60 t 61 <210> SEQ ID NO 323 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 323 gattaagtaa tttgtctaag ggcacacagc ytacaagaga tgacgtcaga ttttggattt 60 g 61 <210> SEQ ID NO 324 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 324 tgacaagtta ctctaacata atagcgaact rcaaactgca cagggctttg gagcccaact 60 g 61 <210> SEQ ID NO 325 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 325 aggcacattt gaagacaagt ggcctacagc ratgctcaga tttttgtgtg cattttcaat 60 c 61 <210> SEQ ID NO 326 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 326 tgaaagtagg taaaagccct gacttataac mcaaggtaag agagcagtca gttatttact 60 t 61 <210> SEQ ID NO 327 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 327 caggctttga aagtttaaat gtgccaccca mgtgcaaatg aggctgattc atggtatact 60 g 61 <210> SEQ ID NO 328 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 328 acataaatta tattaaaggg tcaggaaaat kttgtttgag gtatgtgagg atgatttagt 60 t 61 <210> SEQ ID NO 329 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 329 caataccaat aatttgttcc aattagacca yagtaaggtt gttaaaaaat aagcaaaact 60 a 61 <210> SEQ ID NO 330 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 330 aaggcaactc aagaacatgg ctgttttaaa ycaaccaggc atggcagcct aagatagacg 60 g 61 <210> SEQ ID NO 331 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 331 ctgggcctct ctcctacata aggcatgggg rcgaattgat ccagaacaac tggtgctatc 60 a 61 <210> SEQ ID NO 332 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 332 taggactggt ttaaattctt cctccatggg ygcaggatga gttatgccca gtattgcttt 60 c 61 <210> SEQ ID NO 333 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 333 ttctctcagc tccaagtaat tcagcacaag watatcactt ccttcttatc aatgtacctc 60 a 61 <210> SEQ ID NO 334 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 334 aagatagtta ttcccacctc tcatctcctc yttctaacat atactacaaa gtttctagac 60 t 61 <210> SEQ ID NO 335 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 335 gtaccaggca atggactcaa cacttcccat kcaccaggtc ctctaattct tctttgtcac 60 t 61 <210> SEQ ID NO 336 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 336 ttcagtgaga cttgacacct gaatgttagc rgttcatagg tcagaagatg cttgaaggaa 60 t 61 <210> SEQ ID NO 337 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 337 attaattatt tctttttaat cttcataaca sttagtgagt ggaatgctgg agctggcttg 60 c 61 <210> SEQ ID NO 338 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 338 tgctgcgtga ctgtaaggtc ttcctgccca yaggttgctc ctggctatta gtactactaa 60 t 61 <210> SEQ ID NO 339 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 339 tctgaatgtt ttagattaaa agccttttca rttggatact ttgcatgtat ttgttataaa 60 t 61 <210> SEQ ID NO 340 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 340 ttgcactgtt cagccaccct ttgtgggaga rgaatcaccc catctggaag atcacagtgt 60 c 61 <210> SEQ ID NO 341 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 341 cacgtctttt cctctctatg gataatggag wacacgctca gctcttcagt ttttgaaagg 60 c 61 <210> SEQ ID NO 342 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 342 tatgttacgt taaaaatcca atcagtcttc ygaacattgt gtattcacga tgctgtgcca 60 c 61 <210> SEQ ID NO 343 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 343 tcagagtcta caaaattagg tttacaaaag kggctgagaa taggggacca acctgggtgt 60 g 61 <210> SEQ ID NO 344 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 344 atcagaccag ataaatcgta attgattttg ytcggctttg gaatggatga ggtgttatta 60 g 61 <210> SEQ ID NO 345 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 345 agattggctt ttagagcagg tactgtggaa rtgaggaaga aagtccctgc catcacatgg 60 g 61 <210> SEQ ID NO 346 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 346 caaagtagac accattgctg cagatgagag yttctcccag gtggactttg ggggaaggct 60 g 61 <210> SEQ ID NO 347 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 347 tattggaatg ggagtgggac tgtatcatgt rttgtattaa cttttgcttc taaatgacac 60 a 61 <210> SEQ ID NO 348 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 348 tgggatggtt ttaaaactgt tgacgttgat kcatcagtgg atctaagatc tggcactctc 60 t 61 <210> SEQ ID NO 349 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 349 gcaggtgaga cacagtgagc cttcaacaac kaactctctc ccaacacagc cctgagaatt 60 g 61 <210> SEQ ID NO 350 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 350 accaccaagc agtgacaagt gaaaacagca ragaggaata agccactgtt cctcaactga 60 t 61 <210> SEQ ID NO 351 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 351 tgttagtgaa ggcttacatc ttagtccaaa yggaatgctg atgccaactc ccatcaaaaa 60 t 61 <210> SEQ ID NO 352 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 352 ttgaagcact gttagccagt tgaaagcttc yattctagcc gactttgcct cctaaacagc 60 t 61 <210> SEQ ID NO 353 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 353 acgttcagaa gaaaatatca tttgtattaa sacctattga caggcacaat aaaaatttct 60 a 61 <210> SEQ ID NO 354 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 354 cagagttgag gacaacttac catcttcccc mgagtagaca atggtcacag tactcaggga 60 t 61 <210> SEQ ID NO 355 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 355 tgcctgaggc ttggagacct tcaataacct sctcaagaac ttcctgacct tacaaagcca 60 a 61 <210> SEQ ID NO 356 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 356 ggcacagacg tctctgagta agtacactga rtagttcacc ttgacccagg agcagaaaac 60 a 61 <210> SEQ ID NO 357 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 357 ttcaagtttg acggcaggca gggtgccaaa rtccccgatg ggattgtgcc caagaacctg 60 a 61 <210> SEQ ID NO 358 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 358 catcccaatg agacaacagc ctaagaatgt rcagacaaat acaaagcagt gtgagctggg 60 g 61 <210> SEQ ID NO 359 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 359 cattagaata tattagtgca cttgtaaaaa ygtgtagatg ctagagcccc acccagctca 60 a 61 <210> SEQ ID NO 360 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 360 cccaagagga gggaccctca ggacacaggt sgtcattgtg actcaagatt atctactcaa 60 c 61 <210> SEQ ID NO 361 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 361 gagctgaaga tctaaggagg gcccacctcc rcgagacctg ctgagggctt acatttggtg 60 c 61 <210> SEQ ID NO 362 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 362 tgggctttgg ggtggaagga cagaagagta rcagtctagg aaagggacta gacatgtagc 60 c 61 <210> SEQ ID NO 363 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 363 agtgctctgc attcccagtt cattcttaag ygttggttct ttctaaggca gtgtattgct 60 t 61 <210> SEQ ID NO 364 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 364 atcccctggt gagaggtttt ccaaaatgca rtaatacaga aagaatttaa gggaagttct 60 g 61 <210> SEQ ID NO 365 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 365 gacttttgga aagactttca gagaagtaca sctcccaaat cctttgacaa actgacaggc 60 g 61 <210> SEQ ID NO 366 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 366 tcacagatac agtcatatct atgtaaagag wctcaaagaa ctactatcat gaagcagtca 60 g 61 <210> SEQ ID NO 367 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 367 aaaataaaaa tacaatttga attctgtgct staagaattg gataatttta tttcactcta 60 t 61 <210> SEQ ID NO 368 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 368 tagctaaaca aagaagcaaa accccaaata rcactatggt ctgaatgttt gccctcctca 60 c 61 <210> SEQ ID NO 369 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 369 attactgatt ggagaccaca ttgctatctt rggaaagtat attacatagt atactatttg 60 g 61 <210> SEQ ID NO 370 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 370 ctgaaagaag atttgtatag gaaatgctga ygtctctttg gcaactgcat aaaaattatt 60 g 61 <210> SEQ ID NO 371 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 371 gaagccctca gaataatggc tgatatgtga yaagcacggt acaagtgctc attattacta 60 t 61 <210> SEQ ID NO 372 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 372 cctagactag ttctttgatt ttaaggcaaa sttctttagt aaagttccta atcattatgt 60 a 61 <210> SEQ ID NO 373 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 373 aggaaggtac atctcctggg aagtagagct wtcacacaat aatcaattca tgcaaaaagc 60 a 61 <210> SEQ ID NO 374 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 374 agttctgcca cttcacaaat tacttaccag matgaggtct agtgagtcct tgctcagact 60 c 61 <210> SEQ ID NO 375 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 375 ggcctgcagg atcttcctcc tgagccctac sgaggcattt actagctttc tcaagttaac 60 t 61 <210> SEQ ID NO 376 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 376 cctcaacttc atgttccctg ctttttccat ytcctgtaag ttactgcctt catattcaga 60 t 61 <210> SEQ ID NO 377 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 377 tcacactctg agttccagca ccataccaca scaaattgtc ttctatggca aagtctcatg 60 c 61 <210> SEQ ID NO 378 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 378 ggtcagggcc aactcaccaa tgcacaggat ktttctatct acaggcagac aagggaggaa 60 g 61 <210> SEQ ID NO 379 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 379 tgttgaataa gtggatttgg atgtaaccac rggcttgcca tatgaaattc tattccatgg 60 g 61 <210> SEQ ID NO 380 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 380 tcctatttac agatggcatg gctgtgctta yggacaatgt atgtgaatta ttatttttca 60 g 61 <210> SEQ ID NO 381 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 381 gtttcaatgt atctatatac tttatactta ycccatgcaa agggaaaata gtaactttct 60 a 61 <210> SEQ ID NO 382 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 382 aaggacagca agatggggta acctaaaata stgttgatag atcacagagg aaataagctg 60 t 61 <210> SEQ ID NO 383 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 383 actatgcaca gacacatttt tccacattat rttgctgctt cagtaaagat gttgtacttg 60 a 61 <210> SEQ ID NO 384 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 384 gtgcgtgctc tgcctgttga tggcaatgtc yctgtttcca atgtccttcc tcatcaactg 60 c 61 <210> SEQ ID NO 385 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 385 tattaggatc ctaggaagag gtacaaagcc rtcagtgtca cgagcatcat ttttaccata 60 a 61 <210> SEQ ID NO 386 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 386 ccccagaata tgattatagg tagaagagag magtcatctg agtggggctg gagctcgaga 60 a 61 <210> SEQ ID NO 387 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 387 gcctggcccc gttgttttcg ttgcctgctc rtaattttgt gtcctctcag tacctgtata 60 g 61 <210> SEQ ID NO 388 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 388 agaatttaaa ctaagtaact taacaattga kaacataacc tgtatgtacc ctttgtcccc 60 t 61 <210> SEQ ID NO 389 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 389 atgatggcaa gacagaaatt aaaactcata mtctaatgtc aaatcacatt catttccact 60 t 61 <210> SEQ ID NO 390 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 390 ctttgtatat tcctctatag tcagaaacaa yggaatgtcc tagagccctt tagtgaagaa 60 t 61 <210> SEQ ID NO 391 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 391 ctttagtgta tgaaggacct tgagtgccat rgtaagagtt ttggccacac aacatctgat 60 c 61 <210> SEQ ID NO 392 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 392 tagcctgaga ccaaagcacg accaacagct rtacctggac tggatccttt tcttctctgc 60 t 61 <210> SEQ ID NO 393 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 393 tatcttctga aattctatgc ttcttctaca rtctcaaatc tcatatctcc tacaatctcc 60 t 61 <210> SEQ ID NO 394 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 394 aaaataaaac aataataaag tttgttccat ygattgactc aagaacattc ttgtcacaaa 60 a 61 <210> SEQ ID NO 395 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 395 cagggcatta agcacccaag ccaactcaac rcctgcagat ggctcttcct cccagtgcag 60 c 61 <210> SEQ ID NO 396 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 396 ttgtcagttt ttaaaaagtg agatttttga rgcaagagat gtcataccaa aagctagaga 60 a 61 <210> SEQ ID NO 397 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 397 aaccaaggtc ccaacatatg aaaataaatt rccaggtgac tcaggccaaa cacaggctgc 60 c 61 <210> SEQ ID NO 398 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 398 tatacttgaa ctaaaagaat agcagcagat ytaaaggaat gcagaagcag atctgaagat 60 c 61 <210> SEQ ID NO 399 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 399 tgggcttatt ttctgattgg agagaaccgc rtacagctat gtaattatta caacgtataa 60 t 61 <210> SEQ ID NO 400 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 400 attgtcctgt gaaaccctgt tataacattt yagtggcacc aaaaaagggt gctgggacag 60 g 61 <210> SEQ ID NO 401 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 401 tcctgcgagc ggtccctcac cactgatgag yagaacgtgg agagataaac ccccccagct 60 t 61 <210> SEQ ID NO 402 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 402 gagtgcatgg atgttacctt tccatgcttg ycgctctctg caaagtctag ctggagatca 60 a 61 <210> SEQ ID NO 403 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 403 gctttttagc caggctgcta ggaaatactc raaagattct agagaccctc cctacctgcc 60 c 61 <210> SEQ ID NO 404 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 404 aagtcataac tgtgagtatg aatatatgcc ragtcctgtg aatcctccta gtaaaacatc 60 a 61 <210> SEQ ID NO 405 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 405 gattacacca gtacctgatg gtcatcaaac ktgtacccac cagccttaga atccattaaa 60 g 61 <210> SEQ ID NO 406 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 406 actggaataa aaatgttttt tgcttcttta sgaatggcat tatacagtac ttcctcaaag 60 c 61 <210> SEQ ID NO 407 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 407 tttatcttta tattttatag atgaggaaat macaatatag aatggttaag ttactgcctg 60 a 61 <210> SEQ ID NO 408 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 408 tgcctgaggt cacaggggtg ggtaagaagt kggcaaaaat aggaattcag gtatttgggt 60 t 61 <210> SEQ ID NO 409 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 409 gaggagtaga tctgtgcaag taaggaggta rtagcagaga tagcagaaaa actggtagca 60 t 61 <210> SEQ ID NO 410 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 410 gacttgggat ttctgagctg ttttacactt ytgcatatcc agcagtgact atggttatat 60 c 61 <210> SEQ ID NO 411 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 411 gaggccaaaa gccacagtca gaggagattt katgacagaa caggtcagat gaagagatgt 60 g 61 <210> SEQ ID NO 412 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 412 gaagataaca aagcatttga ttgactctgt rtggaaaagt agtaggtaca agaaggtgaa 60 g 61 <210> SEQ ID NO 413 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 413 atacttctct atttctgtgt aacactgatt ycttagatct ggatttgaaa tcagaagcat 60 t 61 <210> SEQ ID NO 414 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 414 ataaccaagg tgtgaagtgg gaagggtaga sgaagataga aactaccaaa agttactaat 60 g 61 <210> SEQ ID NO 415 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 415 aagatcccat taacaatagc aacgaaaaga ygagatcact gagaacacat ttaacaagaa 60 c 61 <210> SEQ ID NO 416 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 416 gtcataagag aaagccaata tgcatacctt ytcaggagca cattataaat catgaaaatt 60 g 61 <210> SEQ ID NO 417 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 417 ctacctgcca ccagcaccca agcacactgt stcaggacct ggtgattatc ctgccctatc 60 c 61 <210> SEQ ID NO 418 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 418 catccataaa acagaatagg atgttgctgt staaaagaat aaagatctct atgtaccaaa 60 g 61 <210> SEQ ID NO 419 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 419 gtgacagatt ttatcccaag tcatatttct stgaagaact ccacttgata gcttctattt 60 t 61 <210> SEQ ID NO 420 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 420 ttgtagccat tctttgtact gataagtgca raaggcctga aataaccaac tgggtaagtc 60 a 61 <210> SEQ ID NO 421 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 421 agatccattc cttacacctc tgatgttggg yagagcagga cagaaacaat gtcattccct 60 t 61 <210> SEQ ID NO 422 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 422 ctgtctctga tcttactgtg tccaaagatg kgatccattt tttagggttt tttttaaaac 60 a 61 <210> SEQ ID NO 423 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 423 cgggggggca gggaggccca gatgcctttg yacgtacctt cctcctgctt ggcacaccca 60 c 61 <210> SEQ ID NO 424 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 424 gcaatgttga gggaggggct gggcacaatc ragggttctg tggggatcag gactccagcc 60 c 61 <210> SEQ ID NO 425 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 425 cggtgctgca ccgtggatgt gagtccttgc rcagtggtga aatgtagtag aggagtgatc 60 t 61 <210> SEQ ID NO 426 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 426 tcaggggttg taggagatca gtgatgtcat statgtaaac cacctgcccc agagcagcca 60 g 61 <210> SEQ ID NO 427 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 427 tatattgtaa ttgcattcct ggaaaatatg ktgtttatta aagccatgca aaaactcctc 60 t 61 <210> SEQ ID NO 428 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 428 tgataggagg tagtcttgca gctttaggaa rcacctggat gatgacagga gggaacgtga 60 a 61 <210> SEQ ID NO 429 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 429 attacttggt gactcttgta agcaatgatt raagatattc actaagattc gagttcatta 60 t 61 <210> SEQ ID NO 430 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 430 tctgattgca actggattat actaggcatt ygggatgaag aggatgggct gggagggagc 60 t 61 <210> SEQ ID NO 431 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 431 gtaaaatatg acatactctg cctctctttc stttgttcat tttgttggat tttagcacaa 60 t 61 <210> SEQ ID NO 432 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 432 tgtttgttca gtccaatatg ggtcaccgct wtgagtgaaa gatcccttga catggcaaaa 60 c 61 <210> SEQ ID NO 433 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 433 tgaaactctc ttggcaccat tcacttcggc ytcaatggca ccagaacaga aatgataact 60 a 61 <210> SEQ ID NO 434 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 434 tgaggatgac caaaagccaa ctcttgaccc rtgtacacct gcctaaacca aactcctatc 60 a 61 <210> SEQ ID NO 435 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 435 aaagtagaaa gcctaaatag taactgattc stactgtaat agcaactagg tgaatttttt 60 c 61 <210> SEQ ID NO 436 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 436 aatttggtat cagtcttttg ctgaggtatt mtaataggta cacgagcacc ttttaaaaag 60 c 61 <210> SEQ ID NO 437 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 437 atgttagcgt ccctcttgtt tccagctatc kcacatatct attacttttt tggtctgccc 60 a 61 <210> SEQ ID NO 438 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 438 tctcttccca tccaatccac tgtcaactga ycatcttctc tggtcatgcc attctccagg 60 t 61 <210> SEQ ID NO 439 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 439 cataactcac tttggttgat aatatgtgac rttttgccaa gattcatagc actaagaaca 60 g 61 <210> SEQ ID NO 440 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 440 tgccacatta accactcatt caacatatac maagtgccag gatacagtga ctgttctgag 60 g 61 <210> SEQ ID NO 441 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 441 agccaccaca gcctccgggc tcatctgcac rgacaaaacg aggataacaa gattagtcta 60 c 61 <210> SEQ ID NO 442 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 442 cactgcgaag gaaaattaag cagaactact rgatgacata aaataactga ccatttgtac 60 g 61 <210> SEQ ID NO 443 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 443 cctaaggtga cacttaaggg gctaactcag ktgacagaaa tgtattttaa catgtgtgta 60 c 61 <210> SEQ ID NO 444 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 444 tcacctgtgc ttttggtgtc ctacctaaga yatcacttcc aaatctaatg tcataaattt 60 t 61 <210> SEQ ID NO 445 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 445 ccaaattccc taaaaactag tcccaatatt matccatctc cccacatgta aacatatggt 60 c 61 <210> SEQ ID NO 446 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 446 ggagaatagt cctggcagac caagcgaacg yacaagcaag ggagatgcaa atacaaatag 60 g 61 <210> SEQ ID NO 447 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 447 ttaaagcgga gtaacaacaa caacagattg rtggttattt ggtttggggg agaaatttcc 60 c 61 <210> SEQ ID NO 448 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 448 tgactcttaa aattctctga ggatgctgtc ratagcgaac aacagtgaat attttggggg 60 t 61 <210> SEQ ID NO 449 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 449 aggacagtgc tttctcactg atttatctct satttctctc ttcctctgca gattaccaaa 60 c 61 <210> SEQ ID NO 450 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 450 tatccacctt ttttatagaa gataaactac rtctctcagt ttcaggaaga gactaaaaaa 60 a 61 <210> SEQ ID NO 451 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 451 tacgctcaat tgacaaatgt tttctgaatg ytttctatac actaagcact gagctaggca 60 a 61 <210> SEQ ID NO 452 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 452 cccccaccta tcacctgctt caagactgag rcactcgatc ccctggcttc tgctagcact 60 g 61 <210> SEQ ID NO 453 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 453 gcactggcga ctgactgctc agctgatcct ygtctgggaa ttcactttgg ctgaagagag 60 c 61 <210> SEQ ID NO 454 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 454 ttttgaagta tttagtggat attttattga stgaagatta cacttagttt tcatgttggt 60 a 61 <210> SEQ ID NO 455 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 455 ccttgccaat gggtgagcag gagctgaatt ygagctgcaa tgctttggtt aagcaatgag 60 c 61 <210> SEQ ID NO 456 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 456 ggagtggctg gctttttgtt ttgagttcca yttcctggct cctacgctca acttttgaat 60 t 61 <210> SEQ ID NO 457 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 457 gcggggggga cctcatgatt ccatctttat rgcccaactg ttgattaact tccaaatgaa 60 a 61 <210> SEQ ID NO 458 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 458 attcagcagc atattcaaag agacagagaa kaactgacat gatgctgatg aagcttaaac 60 t 61 <210> SEQ ID NO 459 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 459 tgtttgggtg gctggctttg atgcagggat kcttaagtct ggttttctca tctactgcat 60 a 61 <210> SEQ ID NO 460 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 460 cgtagccttc tgtcaacgct ggaagagagg raaacccaca atgagacaaa ggcagcaccc 60 c 61 <210> SEQ ID NO 461 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 461 aaaacaaatc cttatactca ttcatactcc yggaaatgac ttccgtggga atttaggaga 60 a 61 <210> SEQ ID NO 462 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 462 ataaacaagt ggaggaaagg tctccaaggt ycagtgaatg attgtgaata ttggatgcat 60 g 61 <210> SEQ ID NO 463 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 463 tctaaaaatg tatatatata tgtataaaaa stagcccgat atggtggtgt atacccgtag 60 t 61 <210> SEQ ID NO 464 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 464 agaaataaca tcagtccttt tcttgtgata rcgttggatg acaccattac cttggctacc 60 t 61 <210> SEQ ID NO 465 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 465 cagcctcttc cttggccccc acaaacataa ygcagaaggc ttccaaaaga ccagtgctag 60 c 61 <210> SEQ ID NO 466 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 466 ttgcccatct tgccaaagta gtccaaacac rcttcaatga ggacagttat atttagcagg 60 t 61 <210> SEQ ID NO 467 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 467 atataatttt acagttcaga aaaggtttac wgatcacagc aaaaagtatg gagactattt 60 a 61 <210> SEQ ID NO 468 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 468 gtacaaactg aaaatcagtg gtggtacctg ytaggctttt agacataggg taagtcttgt 60 g 61 <210> SEQ ID NO 469 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 469 atctttactg actctcctga tacgcagact wtggagaaaa agaatcttct atcaaatcta 60 g 61 <210> SEQ ID NO 470 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 470 actggtcctc acatgcctgc tgcccagagg yacaaatgga ccacttaatt gagaaacaac 60 t 61 <210> SEQ ID NO 471 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 471 tcggaagctt acatgagcta catggttctg rggtgtaata caaggcagtg aagccgccgc 60 t 61 <210> SEQ ID NO 472 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 472 aataactgaa ggacaggcag tgaatgcaat rccttttctc attagatacc tcccttaatt 60 a 61 <210> SEQ ID NO 473 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 473 agggtcttgg aagaaatcgg gcaggacata sgccaagtac ttataaccat acgtattgtt 60 a 61 <210> SEQ ID NO 474 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 474 tacatgaaga atcaaaagtt gactgaagag mctttgtaaa catcacgata acagaatatt 60 t 61 <210> SEQ ID NO 475 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 475 cggaatcaca cacttgagct gggagatttt ygcagcactt aaggcatcag gggagaagcg 60 a 61 <210> SEQ ID NO 476 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 476 ggcatatcaa catcttaggg acctgatgac yaatggttta aaagcatgcc agcttttcac 60 c 61 <210> SEQ ID NO 477 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 477 gaagaaaact ctttagtcta aaacaaacaa magaagtcca ctaggtcaga ttctcactgt 60 a 61 <210> SEQ ID NO 478 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 478 ccctgcaagt attgccatga gcaataataa kttttttaag ctcactctgt cagactgatt 60 a 61 <210> SEQ ID NO 479 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 479 taccagtcag acaatattga gaaccatagt rttaagacca aactaaattc ttcatcaggt 60 g 61 <210> SEQ ID NO 480 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 480 aaaatatatt acagctgaca atgtaccata wctatagtgt agtaatttaa ttctgttact 60 g 61 <210> SEQ ID NO 481 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 481 ccacttgatg aagtaaatat tcgagtaaaa ratctgaaag agacctgagg cataggcacc 60 t 61 <210> SEQ ID NO 482 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 482 tacaactaac tgagtaggct cttctgtcat ratttggacc ttaagggtaa agtgtgtggg 60 a 61 <210> SEQ ID NO 483 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 483 aagtataaaa aaaaaagtta catttgaaga sagcaatttt ttaaattaac cactttataa 60 a 61 <210> SEQ ID NO 484 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 484 ttatgaggag tacaaaaaca aatcaaaagc staagaattc gttgctagcc atgaaagtcc 60 t 61 <210> SEQ ID NO 485 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 485 agataggcta gaaatagaat tgccaggtca rtatgtgtga agcatgttta aacattctaa 60 t 61 <210> SEQ ID NO 486 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 486 actgccttga gacatttgtt gtttgcttat rggttggtga gttgtctgga gcttgatcta 60 a 61 <210> SEQ ID NO 487 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 487 ataggtttct tcctgttctg agattcctct saaccctacc tctgttgttt gtttagatac 60 a 61 <210> SEQ ID NO 488 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 488 tcctttgctg tgggtccctg tcctgggcac ygtagaattc ttagcagctt tcctggtccc 60 t 61 <210> SEQ ID NO 489 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 489 tgaaacttgt caactcgata ttttctcaca wttcagaaca agcagggaaa caacaacaac 60 a 61 <210> SEQ ID NO 490 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 490 ttagacccaa acatttaatg tgccttttac rcaacgaatg atcaattatg ggaatgtgac 60 a 61 <210> SEQ ID NO 491 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 491 cgatttacaa taggaaaggc agggaatcaa mgtaggtgcc catgaatggt ggattggata 60 a 61 <210> SEQ ID NO 492 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 492 aactgaagct ggaccctggg cttctgagtc yaaaggtggt acttcctgtg ctagaccgtg 60 c 61 <210> SEQ ID NO 493 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 493 ttttgtactt catctcccaa tatgcagacc ytgcttcaaa gagccagatg acatgtaata 60 a 61 <210> SEQ ID NO 494 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 494 gagctttgat ctggactatg taggaaggac wtttcagttg tgtgccttac tttgtacagt 60 g 61 <210> SEQ ID NO 495 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 495 tgtagttaga gctgcaccaa caccactacc wacattagca ttcatttttg ggcaaaataa 60 t 61 <210> SEQ ID NO 496 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 496 acactttgtt gtcatttaag gttgaatatc sagagagtag cctgagtcat gctctgtcac 60 t 61 <210> SEQ ID NO 497 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 497 tttacattat gcaatgaatg ctaattgaca rctgattcat aattagttaa ttgtaaacac 60 t 61 <210> SEQ ID NO 498 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 498 cagacatttt tagctccagg tgaattgacc rtagactcac tggtatggca caaaggaaaa 60 a 61 <210> SEQ ID NO 499 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 499 gaaactagag aggattgagg atatttttct ygttaaaacc cagaactgga ggatcctagg 60 g 61 <210> SEQ ID NO 500 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 500 aggtgggtaa taggatctgg gcatggcttc ygcatggaaa ttagtttccc tggttgcctg 60 c 61 <210> SEQ ID NO 501 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 501 attctaagaa aagaatcacc gatgtgcaaa wagattcgtt accagagaca gcaggtgtcc 60 c 61 <210> SEQ ID NO 502 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 502 tgagcactaa atgttccttg agtatgctca ratgactgta atagcagaca ggacatatcc 60 a 61 <210> SEQ ID NO 503 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 503 tgataggctg agaaggaaga agaagaggaa rggttggttt ttctgtctca gaggtaacag 60 a 61 <210> SEQ ID NO 504 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 504 tttcattgtt gccttataaa ttttcctgat rtcatgacct aattttactt cagagaagta 60 a 61 <210> SEQ ID NO 505 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 505 accaaagaga ccagagtaat aaacttctca ycagtaacta ggaggatcct cccacaactc 60 c 61 <210> SEQ ID NO 506 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 506 ccatcgcctt acatgggctg atgtgcaagc yctcctaaac atcatgctca cggcagatga 60 g 61 <210> SEQ ID NO 507 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 507 gaaatagttt acatgaaatg gtgaccaaat rtggactcaa agctatgaaa atgtactata 60 c 61 <210> SEQ ID NO 508 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 508 attcctaact cattaatgcc acctaaatcc rccccagtct ctacatctcc cctgctacca 60 t 61 <210> SEQ ID NO 509 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 509 aacagtaagt gaactcattt atacagatca yctcagtttc aaaagaaatt ttacttgact 60 t 61 <210> SEQ ID NO 510 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 510 acaaattaat tacatcagaa ctgtggtaaa yctaattctc aacattatgt gatcattaga 60 g 61 <210> SEQ ID NO 511 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 511 gcacttgaac aataaaagaa atggatttcc raactgagtg caacgttttc tgggctttat 60 a 61 <210> SEQ ID NO 512 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 512 tagcaccttt gggggaactt ggggaagtag yaatgaatgg tggtctctat ggtaagactt 60 a 61 <210> SEQ ID NO 513 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 513 cacttcttac cccaaaatat acagatgaat satttaacct tatgagacct tggttttctc 60 a 61 <210> SEQ ID NO 514 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 514 ccttgcacct tacatatttt gttctcacac yttttaccac aatattaata gctaacttta 60 c 61 <210> SEQ ID NO 515 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 515 ccatgtaatt gaagaaggaa gagtttgaca ygaagtaaaa gtctctgata ttgatctatc 60 t 61 <210> SEQ ID NO 516 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 516 cgtaattttc actaagctca tataatgtat yacaaaaagc atcaagacat caaatgacag 60 a 61 <210> SEQ ID NO 517 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 517 taggacacta agaaatcatt gtccacatga rctaaacaag tatctctgtt atctaaatgg 60 a 61 <210> SEQ ID NO 518 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 518 atcaaccaag ggagtgatat aaactgcatt matttcaagt ggtctaactt agttattgtc 60 a 61 <210> SEQ ID NO 519 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 519 cactcttttt ggtgtatagt tctgagtttc racaaacaca tatcgtcgtg taaccatcat 60 g 61 <210> SEQ ID NO 520 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 520 gccctcagtc tccacccagt ttgctgagat staccactgg ttttaaacaa gaattttcca 60 g 61 <210> SEQ ID NO 521 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 521 agttcttgat atggctatat cccattccag rcatagaggc aggctttagg gatacaatga 60 t 61 <210> SEQ ID NO 522 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 522 gagatttaga ttgctgaggc atttcctatc mtaactcagt aggttcttaa gattttactt 60 t 61 <210> SEQ ID NO 523 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 523 aataacacat acatgcattt gttcagtctc ytataggcca taaattactt ccataaatat 60 t 61 <210> SEQ ID NO 524 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 524 actttggtta atttatcaag gaaattttgc matgattatc ctgtcctata atgcgcaagt 60 t 61 <210> SEQ ID NO 525 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 525 taaatgtgaa ttcatgccta ctttcaacct rcactgctct gattgccaag tctactgaga 60 a 61 <210> SEQ ID NO 526 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 526 tttatatgac aacctcacac ctcctataag raagagcctg ctgtgcaaga ttctctgtgc 60 a 61 <210> SEQ ID NO 527 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 527 ataatgcttt catgtgtacc attggctttc yttgaaaatc acacatttgt aaattttgaa 60 a 61 <210> SEQ ID NO 528 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 528 tataatcatt cactaaagat tgcctactaa ragataagag tggccaggta tgtacatgtg 60 t 61 <210> SEQ ID NO 529 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 529 attgtcagct aacctttact tgcacatgta yggtagcagg gagtttgcta ctttgggtat 60 c 61 <210> SEQ ID NO 530 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 530 tggtgatctt cttcttcttt tggttttgtc ygtatatgag gaccgtgcca gagtgtgagt 60 g 61 <210> SEQ ID NO 531 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 531 catcagagat agataatttt ctccacctgt rtaatgattt catctctatc tatatttccc 60 c 61 <210> SEQ ID NO 532 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 532 aaacaattat accttcctct agagttctgc raagtttatt tatttacttt tattgttaat 60 t 61 <210> SEQ ID NO 533 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 533 tcctcatgca gcaattaaaa gcactaacac yggaatagtt tggacctctg attgagacaa 60 c 61 <210> SEQ ID NO 534 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 534 taatacaaag atgatgacca cttccttcac rgacttcatg ccctgtgaag cagaatttac 60 a 61 <210> SEQ ID NO 535 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 535 gttatttcct gcttataaaa tttttgttga ytttgaaggg cctatgcctt acatcaaccc 60 a 61 <210> SEQ ID NO 536 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 536 cattcctttg tccctagctc atgcaaacca rtgaaagcaa tgttatttta ggaataactt 60 c 61 <210> SEQ ID NO 537 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 537 atttggggtt atgaggagta aaataaatgc yggtattaat ggctaaattc taaaagataa 60 g 61 <210> SEQ ID NO 538 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 538 tgggcttatg taatatttgt taattaactc maagatccat tcagggaaga agggggttaa 60 a 61 <210> SEQ ID NO 539 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 539 gccaggcaca attccaggta gcctacgtac rtaactttat ttaatgaatt ttcctaacat 60 t 61 <210> SEQ ID NO 540 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 540 ttagagcact gtttgctatg tatcaccatc rttttcattc ataatataag aaaagttgaa 60 t 61 <210> SEQ ID NO 541 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 541 tgattagtag aaatgaactt agatgggaat ygaacctgtc taagcccatg aactgtttca 60 a 61 <210> SEQ ID NO 542 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 542 atgttcgaga gacagaacgt ctccgagaca rtaaccaaag taaaggtgtc aacgtacctg 60 a 61 <210> SEQ ID NO 543 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 543 ggagaggctg gcaccttgat cttttgcagc rtcctaaact gtgagaaata aatttctgtt 60 c 61 <210> SEQ ID NO 544 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 544 tgtgtttgtt actacctctc ttccatatta yaccaaactt tgagttggat ggggagtgac 60 t 61 <210> SEQ ID NO 545 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 545 ttgctttggt acaacagatg aagtttccca rtaatctgct gtgtcgggaa ttagttgagg 60 a 61 <210> SEQ ID NO 546 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 546 tttacccatt cacctatgga aaaaatcttc rtcgcattca atttaggata attttgaata 60 a 61 <210> SEQ ID NO 547 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 547 aataattact gaaatctcaa actctactac ygttttctct gagaactcta gagagatgct 60 c 61 <210> SEQ ID NO 548 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 548 gcaattacac actattttct gttaaatgac rtggtagacc acctgagaat atttcaaaaa 60 t 61 <210> SEQ ID NO 549 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 549 attaaggata gagataaaaa agcaaggaga ycagtcttaa gagtaacata atcgatgtag 60 a 61 <210> SEQ ID NO 550 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 550 taggaagggg caaaactggg attcacatcc rcctaccaca atctaacaac cttgattttt 60 c 61 <210> SEQ ID NO 551 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 551 aacgtgaagt gactgactta ggacggtaat kaggatggta acatttaatg ctatgttcta 60 t 61 <210> SEQ ID NO 552 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 552 ttattggttc gaactcaccc agctatattt ktactgtgct tgctatatac atgatttaaa 60 a 61 <210> SEQ ID NO 553 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 553 agaatagtgt ggggaacggt tctgctacat kcctaaaagg agcaaaggga aattaatatt 60 g 61 <210> SEQ ID NO 554 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 554 gtagctggga ttacaggcat ctgccactac rcgtggttaa tattttgtat ttttagtaga 60 g 61 <210> SEQ ID NO 555 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 555 tggagtaagg gattagttct gtgtttcctt yggtttggtt gttggagcaa tattaccagc 60 a 61 <210> SEQ ID NO 556 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 556 atcataattt ataagtcata aaatatcaag sagaagagtt aacatcactc aaggacttta 60 t 61 <210> SEQ ID NO 557 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 557 taccggggta catttacagc ttccgattag raagttaaaa catctttaag tatatgaact 60 t 61 <210> SEQ ID NO 558 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 558 tctcacagcc tcacctgtat ggataatttt rtcagccaaa tagagtaagt ggatcttagt 60 t 61 <210> SEQ ID NO 559 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 559 tgggagttga gggagaagac tggcttttta mtttctacct tgctgttgtt ttaattttta 60 a 61 <210> SEQ ID NO 560 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 560 ataagcaacg tggtgtgtaa tttacaagaa sacttaaaga actctcagta ccttggtgcc 60 g 61 <210> SEQ ID NO 561 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 561 ggatgacttg gacaaccctc cagaaacaag kttagctggg agaaacattg tcctggtgta 60 a 61 <210> SEQ ID NO 562 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 562 agagaaaagg tttaagacct cttagcacag yttctaacac atagtatagt cagtgttcgt 60 a 61 <210> SEQ ID NO 563 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 563 tgagatacct gaattaacat ttctaggtct yttgttcaaa tgttaataaa gccagtgctt 60 c 61 <210> SEQ ID NO 564 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 564 gggtatgccg gacacagggc ctatagtcac ygttagtttg gctaaataaa attgaaaatc 60 a 61 <210> SEQ ID NO 565 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 565 ctgtgtttga aatctctatt tagctagcca ygtggatgtg tcaggccggt agttgcaaat 60 a 61 <210> SEQ ID NO 566 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 566 ccagatggaa aaatccactg attgcacaac rtatggaata aacccagacc caggcacgtc 60 a 61 <210> SEQ ID NO 567 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 567 ccaggagggt gacagctgtg catcaggaat kaagggcaag ttcagattga agcctcgtgt 60 c 61 <210> SEQ ID NO 568 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 568 catcatcatc atcatcatcc ccctcacaat waccgtgtgg tggttaattt tgtgtgtcat 60 g 61 <210> SEQ ID NO 569 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 569 taacatatct tctttacttc caagttagtg yttttcactc tacatcatgc ccaacacttt 60 c 61 <210> SEQ ID NO 570 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 570 caacaagccc caaacacaag aaatgtgaac raaactacac cagggcattt ggttatgttt 60 a 61 <210> SEQ ID NO 571 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 571 ttaaagcaag ttggattact tggttatttg yttcttccca acactctgca aagtatttga 60 c 61 <210> SEQ ID NO 572 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 572 cagaagtcag aagagaggcg cgaagcagat ycttctctgg accgcagagg tgtggccctt 60 g 61 <210> SEQ ID NO 573 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 573 ttattgtatc tggtatcagg aagaattcta rgagaagaaa gcctgattcc caataaggtt 60 t 61 <210> SEQ ID NO 574 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 574 atagtgacct ctggccctgc actcccctac staagcctgt tttccaccaa gatgcccgat 60 c 61 <210> SEQ ID NO 575 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 575 gaccctattg ctttctgctt gatatgttgg rttcagggag agcaagggct cctacaatca 60 c 61 <210> SEQ ID NO 576 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 576 gaaagttttg aaaacttttt gtctgtaatc ygtggaaaaa tgcactgacg tagtacacaa 60 a 61 <210> SEQ ID NO 577 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 577 tctgtaatcc gtggaaaaat gcactgacgt mgtacacaaa caccccccca acatacacac 60 a 61 <210> SEQ ID NO 578 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 578 caataacccc tgtgcgctgc attttatgtg wtgcgagaca ggtgtgcaac tgttgaatgc 60 a 61 <210> SEQ ID NO 579 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 579 ctgctctctg agtagaaaat tataaggagc ytcttgtgga ttgcagagct gttgtatggc 60 t 61 <210> SEQ ID NO 580 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 580 attccctatt agtcccttct tttcatttct stgtctatcc agcttggagt ccatggttca 60 t 61 <210> SEQ ID NO 581 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 581 ttaacgtaca gattgactgc atgatgcact yagatttcaa aatgctaaat cttggtggga 60 a 61 <210> SEQ ID NO 582 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 582 caaaattatt aatttgagtt ttttttggat rctgcataat gtcctagagg gttaaaaaaa 60 t 61 <210> SEQ ID NO 583 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 583 gtggcaacta tctatttaac tatgcctaaa yagcaatgtc agttgtgccc cagtttccta 60 g 61 <210> SEQ ID NO 584 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 584 gttctgtgtc ttaaaattat tgatattgtc rttagtcgtt gaattaagca tgaaggtgat 60 t 61 <210> SEQ ID NO 585 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 585 aagcaggagg aggttaaagt acagacaatg rccaagaaac acatccacat aaactagtca 60 g 61 <210> SEQ ID NO 586 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 586 accagtcaac tctcgtatat tgcatacaac ygtagaaggc catcctagac aataatacaa 60 c 61 <210> SEQ ID NO 587 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 587 tggaaagaaa atagacgtaa aaatcaaatt mtgtgaagct gctaaagaaa atctctactg 60 a 61 <210> SEQ ID NO 588 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 588 gggatttggg aggtcattgt ggttacttct ytgcttttag ttagcttgct agccatttca 60 g 61 <210> SEQ ID NO 589 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 589 ttgttctaaa tctttcaaat gatagcggaa ygatcttccc atacttatca agaagtgaca 60 g 61 <210> SEQ ID NO 590 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 590 ggatacaggc aaaggaaaac tgtactaggc raggcccata gaataaattg acaggattat 60 t 61 <210> SEQ ID NO 591 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 591 tcacattccc ctagttacac aatttttctg rtaaccctga atcttgggat cttttacagt 60 c 61 <210> SEQ ID NO 592 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 592 gtcctgaaac agaaaattaa aactctgact sagtgttgtc aggcattgta gaaaagatgt 60 t 61 <210> SEQ ID NO 593 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 593 gctctgaaaa tgctgctctg tagatatgac mttttctgct ttgctgtaga cagtgtaatt 60 c 61 <210> SEQ ID NO 594 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 594 agcaggccat gcttacctta gaactggagc rgtcggccct gctgcagacg gtggaggagc 60 t 61 <210> SEQ ID NO 595 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 595 atttagaaca gaaaggttgc acagctctta yatactcaaa catagtttta gagttagatc 60 a 61 <210> SEQ ID NO 596 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 596 gagcctgaag agagttttac tgcactgaat rggggacaga aagcagtact ggcaacattt 60 t 61 <210> SEQ ID NO 597 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 597 cctcctgagt aacagggtag gtgggagggc ytcctaagaa ctcctttgtc caggagcccc 60 a 61 <210> SEQ ID NO 598 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 598 ccactgagtc tcagctgggc agaggacaaa kaaggactgc atgtggttgg tggtcttaga 60 a 61 <210> SEQ ID NO 599 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 599 cttttctagt ttccaaagtc cataatttcc rgacagcagg aatagttatg caaagaacag 60 a 61 <210> SEQ ID NO 600 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 600 agactgtaaa agatattgga aatggatcaa rgcactctga acatattcaa ataattgctg 60 t 61 <210> SEQ ID NO 601 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 601 aagatggccg tgaattagga tgtatgacag ygagacacgt atgtgcacca ttctggtctt 60 c 61 <210> SEQ ID NO 602 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 602 ttcattctca aagagctaaa tttgttttgg kgtgagaggc tgataattag gttgaccctt 60 g 61 <210> SEQ ID NO 603 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 603 gtctaacgtc atctggagaa ctgtttaagc rgaatccttg cccttctgaa cctatccaca 60 t 61 <210> SEQ ID NO 604 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 604 cgccatcccg caaccccctg ttatgttcat rtacttccac ggttctcgcg tcatgcctgt 60 g 61 <210> SEQ ID NO 605 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 605 tcagtgagtc atgagttctt cctttttcag ytagtcaggc ctggcttttg ttcaagtcct 60 g 61 <210> SEQ ID NO 606 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 606 caaagaacag gcaagatctt cataggctga rtttagtctg ggaaggtttt gtgtgggatg 60 t 61 <210> SEQ ID NO 607 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 607 cctggctttg gggatttccc ttgattacag mtagcctata tacattgcag aatacagaaa 60 a 61 <210> SEQ ID NO 608 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 608 tacttaccaa acgggatggt aacttggaca ytgtgtcagg gaagaggcac ttggtcctct 60 g 61 <210> SEQ ID NO 609 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 609 tgttgtgcta tcaaaaatta gatctgattc rttgcatcta actatatttt tgtactcact 60 g 61 <210> SEQ ID NO 610 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 610 agtggtatga ggtactgtgt agagcaatga wtcacaatta tttttgcact ttgatttgag 60 a 61 <210> SEQ ID NO 611 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 611 gtttagaatg ggtcttgtgt ccttgctttg yggagttttc aaatacaaga cttctaaaag 60 t 61 <210> SEQ ID NO 612 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 612 aactctctca gcagagttcg tagtcttgtg yttccctttc tacttactca tgatctcctc 60 t 61 <210> SEQ ID NO 613 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 613 gtatgatttc ttacaactat gtgtgagtct rtagttatct caaaataaaa tgttaaaaaa 60 a 61 <210> SEQ ID NO 614 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 614 actaatttat atttcttcct cttcctattc kttggccatt ttccctgtgt attttttgtt 60 t 61 <210> SEQ ID NO 615 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 615 tattttagtc actattcctg cactctttcg yttattctag agaaaagtgg gctaaactat 60 t 61 <210> SEQ ID NO 616 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 616 tgccctatta aaggggagac tagtaggatg ygctcttctg aaaccaaaca gcgttgtggg 60 c 61 <210> SEQ ID NO 617 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 617 tctctctaaa atctatcaag ccttgggcta kggtaatgag tcggtaaagg agacaaaatg 60 t 61 <210> SEQ ID NO 618 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 618 ggccaacctc tgctgccgac cagcatctac scggtacctt ccctggagcc acactttgcc 60 c 61 <210> SEQ ID NO 619 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 619 ggtttggaat gtgagtgact tcctctctgc statctatga acactcagac tctgggatag 60 g 61 <210> SEQ ID NO 620 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 620 cgattgaggt aggagtctcg gtcttgtctg wgtcattata tatgagtcag ttactgtaag 60 a 61 <210> SEQ ID NO 621 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 621 cagcatgccc gtgggcaaca acatagataa mgtcctctcc aggtaggtgg ctcccagtgg 60 c 61 <210> SEQ ID NO 622 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 622 ctggtcaatg tgatacttcc cgctgttagc staggatacc taggagggaa ggctggatgt 60 c 61 <210> SEQ ID NO 623 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 623 atttgggcag gttctttaac ctcactgaac ytcattctcc tcatctgtaa aatgggacac 60 a 61 <210> SEQ ID NO 624 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 624 tcaacatatg aaggagacag ctaattggct mttctatgca aagtcagctt ttaaaatgac 60 a 61 <210> SEQ ID NO 625 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 625 aaaaaaaaat agaactgaaa ctaacaagta sagactgttc aacatgtgtg atggtaaaat 60 g 61 <210> SEQ ID NO 626 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 626 gttaaatgca aagagctgaa gttgttagta ytcacagaac agaaattttt agctaacagt 60 a 61 <210> SEQ ID NO 627 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 627 aacctctcat tcaagtgaac tatcctcata rgcagtcgag atacaatatt tttttaaagt 60 t 61 <210> SEQ ID NO 628 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 628 aaatcacagc atttggggac tgcagtttgt ytcagccaag aactagagct tggaagtaat 60 a 61 <210> SEQ ID NO 629 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 629 aagtctcaag tatttctcac atactttgcc rtttttattt ctacatttga ttaccatata 60 a 61 <210> SEQ ID NO 630 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 630 tctttgccta cacactactg acctcctgct ytgccctaac ttcacgatgg agttacttat 60 g 61 <210> SEQ ID NO 631 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 631 tttttgattt gtttgtttca ctgtttttca rgtctgaata gcttgcattt gtttaaagca 60 g 61 <210> SEQ ID NO 632 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 632 gaggaagaac actgcatgat acaggctgtg ygatagtggt attattcaag ttcccttgag 60 c 61 <210> SEQ ID NO 633 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 633 taatctgagt cttccttact ttggctccaa rgatccccta aaagactgcc agagaatgag 60 a 61 <210> SEQ ID NO 634 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 634 ccagatatgt tacatacatt acctcattgc rtcctcaaaa cagttctgca agggaggtat 60 t 61 <210> SEQ ID NO 635 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 635 caggcagggc ctgaatttgg ccagcatgcc rtggtttgct gacccatgtt atggttctta 60 t 61 <210> SEQ ID NO 636 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 636 acatcaatat ggtgacaaag aatttacagt rggagatagt tattgaatag caaggtttat 60 g 61 <210> SEQ ID NO 637 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 637 catctctcac tacatcatgc agtagttgta yttccaggcc ctgaattccc attaattact 60 g 61 <210> SEQ ID NO 638 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 638 agttgtagct gaataaataa aaattcttgt yattgaccac attatttggc atttccctca 60 t 61 <210> SEQ ID NO 639 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 639 ttctcactgc ttccttattt gtaatgtaaa ygatctgaaa tgacctaaat gtctctcagt 60 c 61 <210> SEQ ID NO 640 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 640 aagcattgat gttacggcta gtactaacta yagcctaaac tgcaaacaac tgaataaaag 60 g 61 <210> SEQ ID NO 641 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 641 caaggtaggg ctcagtccac aaaagagaga ycgaaaagtt agcaaagtac gtttagtaaa 60 a 61 <210> SEQ ID NO 642 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 642 aaaaaaaagg actgaccaat ttctttttcg ytgaatcact ttcttcatct tctcctcggt 60 c 61 <210> SEQ ID NO 643 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 643 ggcatcctag ttctctgtac tgggctcctc yagaaagttt atcagattgc tcctgatatt 60 t 61 <210> SEQ ID NO 644 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 644 agaaattaaa actgtgcttt tcttaaagcc ytgaaaatgg aagctaaaca acttaaatga 60 a 61 <210> SEQ ID NO 645 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 645 aaatattttg cttaggtttg tatcatttaa wtacagatgg gagagtggat ttctaatctt 60 c 61 <210> SEQ ID NO 646 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 646 cttcagtttt ctaaattatg tttgacatca rgacagtcaa gtcagtccag gatgagaaaa 60 g 61 <210> SEQ ID NO 647 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 647 tcaccaatat cggtatcaca cagtctcgca ytttacataa ctgaaaaatc tgcgatcccc 60 t 61 <210> SEQ ID NO 648 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 648 gatcagaact gcatgttgtt aatgacaatt rtgccaaaaa ataccccttg agtacattag 60 t 61 <210> SEQ ID NO 649 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 649 ctaattttta acaaagttac tgacttttaa ytcacagaga aaaaaatgat ggtatgggag 60 t 61 <210> SEQ ID NO 650 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 650 cctgaaagaa ttgacaaaaa gctccaggaa mtaataagca attatagcag ggttgcagga 60 t 61 <210> SEQ ID NO 651 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 651 tagggcattg taatgaccat gagaattcat sggtagatct gtgagagaat ggagcatcaa 60 g 61 <210> SEQ ID NO 652 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 652 gtgcaataat tagcagttag gtcagtatcc rgcacatagt gagcattcaa taattagtga 60 c 61 <210> SEQ ID NO 653 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 653 agaaaaacca tagtgtgttg gccttgtaag ygggcttaga gattgtaggc atgcattggt 60 g 61 <210> SEQ ID NO 654 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 654 aagaacaact agtaaattct tgactaaaat mctactgatg aagtaaaatt ctaactcaaa 60 a 61 <210> SEQ ID NO 655 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 655 aggagaaaaa gaatattaca gttgaaatag scttcatttt cttcctagtc tctttacccg 60 c 61 <210> SEQ ID NO 656 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 656 gaaggaagga taaaagttag gaagctctac wgcatttgat tggttgttgt acctcgtcac 60 c 61 <210> SEQ ID NO 657 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 657 ttgtcttagc tacttttcga tctattttgc rcatagcctt ggatattctt gattttagta 60 t 61 <210> SEQ ID NO 658 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 658 agggggagaa gagaacaagt aaaggaaaca yggtgagtgc tgtggcagga tggagatgac 60 t 61 <210> SEQ ID NO 659 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 659 actcaggaaa tatacctaga aatcagagtt wtggataccc tgtgatcaag acaatcaatt 60 t 61 <210> SEQ ID NO 660 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 660 gagagtaggg gaggtgtcaa aatggataac rtaggcaata acagccaaat atgcccgtgt 60 t 61 <210> SEQ ID NO 661 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 661 tattaaacgt tacaaactgg aattctgtca rttaattcct atgtactttc atatctgtat 60 t 61 <210> SEQ ID NO 662 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 662 tctgattggg aatggacact atcagaatat wccgtcctgc tcacagaata tattataagg 60 a 61 <210> SEQ ID NO 663 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 663 gaaaaggaat tctgaggaga gagtgatcaa rgtagcttaa atgttatatc agttattcat 60 t 61 <210> SEQ ID NO 664 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 664 aagtaatata tttagccaat actggttatc ragagagaga gagagagaaa gagagagaga 60 g 61 <210> SEQ ID NO 665 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 665 atatgtttat gaaaaagatg cccagtttca ractcttctc cttactctct agctatagcc 60 c 61 <210> SEQ ID NO 666 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 666 agttagagtt caggcactta tcagctaaat raccttgaat ctgtgactag ttatctacaa 60 a 61 <210> SEQ ID NO 667 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 667 acttgaaaaa gcataatctc ttgttgacaa ygccacagtt tacttctact aggaaagttt 60 a 61 <210> SEQ ID NO 668 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 668 agttcctaaa catggtcctg ggaagagata yggtgaacta gcaatattat tcattctaac 60 a 61 <210> SEQ ID NO 669 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 669 tttcttttaa tctaatctta attcttctgt scaagctaat tttcctgtac acatttattt 60 t 61 <210> SEQ ID NO 670 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 670 tgttcatctt ctcgttatct tcagaatctc rtactttgca tatatttaat ttattcttgt 60 c 61 <210> SEQ ID NO 671 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 671 aggcatatat tgctatcaat catcaatttt rggcattacc tacttatctt ttttatggta 60 a 61 <210> SEQ ID NO 672 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 672 atgtgtgtaa gttggagact gttgagtgac yaaaagtttg cttctctcat tgaaatagga 60 a 61 <210> SEQ ID NO 673 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 673 actgacttaa atgggagcta caaagaaaca yagacagtgc caagaagtca tcttaatagg 60 t 61 <210> SEQ ID NO 674 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 674 aaaaccctat cctctacctt acttatgcta ycttacttct ctatcctttg tgtaatttct 60 g 61 <210> SEQ ID NO 675 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 675 tgttatgggc tcatttatta gtggaaactc raacaaaatt catatcctgg tggtacacat 60 t 61 <210> SEQ ID NO 676 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 676 tgagaatctt gcattttctc tgccagttac rtttgtattc atcttagcac tgatggaata 60 a 61 <210> SEQ ID NO 677 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 677 ggctagagaa ggccagccct gatggccaac rtcctagcag aatataaggt gcttatccaa 60 t 61 <210> SEQ ID NO 678 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 678 agccttagac atcttcagta tctcctgaga magttacctc ttagaaggca gctgccatac 60 t 61 <210> SEQ ID NO 679 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 679 ttatatagat gtgaaccagg aactccctga ygaggtgatt ttgaatagag agttgaagga 60 g 61 <210> SEQ ID NO 680 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 680 ggccttttaa gtgtttttga aatatagcct maactaagaa tggtaaaaat tccatcaagg 60 t 61 <210> SEQ ID NO 681 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 681 ttattgtcaa ggggagaaga taggtgtcct ycatgtaatc ataccaataa acacagcatt 60 a 61 <210> SEQ ID NO 682 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 682 atttgatgtc atttggaaga aggattccag yggaaacaaa accatatatg agaggaggac 60 t 61 <210> SEQ ID NO 683 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 683 ttgcctatat tcccaaagga ttaaaataaa kctaagtaca tttccccaaa gtttgaaacg 60 g 61 <210> SEQ ID NO 684 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 684 ctgctagaac acacgacatg aaattaggaa ygacagtaag gctagaatct gtatcacgaa 60 g 61 <210> SEQ ID NO 685 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 685 taattagcac atgaaaagtg aacatgaaga rataaacaga ggtgatttgg agaggtgaaa 60 c 61 <210> SEQ ID NO 686 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 686 cacaaaatat gtgtcaattc cacaatccac maagagtttt ttctcttcac caaactcctc 60 c 61 <210> SEQ ID NO 687 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 687 gaacaactct catgtataca actgaaaaat yacaaaggtg tattcactta acacaaagtg 60 a 61 <210> SEQ ID NO 688 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 688 ggacaatcaa ttgctcaatg gcagcaggta wttttgactt cactctctga tattcagcta 60 g 61 <210> SEQ ID NO 689 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 689 actggcaact tccctcttcc agaaacgaga yagatacaaa aggaacttca gtaacatgaa 60 g 61 <210> SEQ ID NO 690 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 690 tagaacgagt tgcggaagtt catggatgtt rcatttgcaa agattcaaaa cacaaatcaa 60 g 61 <210> SEQ ID NO 691 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 691 caacaatcaa tgtaaatggc ttaaacttgc rattaaagga aagagagtct cagctgtttt 60 t 61 <210> SEQ ID NO 692 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 692 aatcaggatg acttcagtgt tggccacatg bttatgggtg gatggccttg ggtacatcta 60 a 61 <210> SEQ ID NO 693 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 693 tagacattag acttcagagg actattgtga rcattaaatg agattatgca tgggatgtgc 60 t 61 <210> SEQ ID NO 694 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 694 atgtgatctt ggagacaata ttttatgttc ytagtctcta gttttcctat ttttgaaata 60 a 61 <210> SEQ ID NO 695 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 695 cataactggt tacccttaga tagtgtccaa yaaggcacct caaaatattc taagtgctct 60 a 61 <210> SEQ ID NO 696 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 696 ctcagcctcc cgagtggctg cgactacggg matgtgttac caagccaggc taattttttg 60 t 61 <210> SEQ ID NO 697 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 697 aggaaggaga ataactggca acccatttta rtctctaagg ctgagatatt acatttcatt 60 t 61 <210> SEQ ID NO 698 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 698 tagtcatagt tataagcttg aactctgcag yagggccggc tgggattgaa ttctgactct 60 a 61 <210> SEQ ID NO 699 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 699 cacaaggcaa aattgctggt ccatttccat rctgatgcta gttgcagaca ttgtatttca 60 t 61 <210> SEQ ID NO 700 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 700 tagtatggta ctcacaatcc tagagattcc ygtctcctgg ttcttcaacc aaacactaat 60 c 61 <210> SEQ ID NO 701 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 701 tacctaccac ccccacaagg caaaaggagg raatagtgag acaagaattc ttctactcca 60 g 61 <210> SEQ ID NO 702 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 702 tcccacaccc actttatttt tttctcatcc rtgaaaacta gatatctaga aactactgct 60 a 61 <210> SEQ ID NO 703 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 703 aatgtgagta gctgtttata cacagatcca ygaggaagct gcctctttta tggacactgc 60 a 61 <210> SEQ ID NO 704 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 704 aagcatattg actgccctta actcaagccc ytaactctct aatttcactg atttctataa 60 t 61 <210> SEQ ID NO 705 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 705 caattctcca actttttgtt gaatgacttt rcagcaactt ccataaagtt atggagtcta 60 t 61 <210> SEQ ID NO 706 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 706 atgccagagc attgtcagga ggcagggaaa yagactccat aactttatgg aagttgctgt 60 a 61 <210> SEQ ID NO 707 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 707 gtttctccaa gggagactga cattctaagc mtatcagctc tgtctatctc tgctcctttg 60 a 61 <210> SEQ ID NO 708 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 708 aaggattgac aaatgatgat ctttctgtcc rcaaggttct tatttcctgt gcaaaatgga 60 c 61 <210> SEQ ID NO 709 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 709 gctgcttcca aagctactct aatcaccata ktctattatt cctacaaaag cctagtttac 60 c 61 <210> SEQ ID NO 710 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 710 tgccaactag gaacaatttt acttcaagac rtttgactct cttctgtact ctatgcagaa 60 c 61 <210> SEQ ID NO 711 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 711 ccccagaagc atctgggacc tttcggaccc rgaagttatg gccaagcgac ctaggctaac 60 a 61 <210> SEQ ID NO 712 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 712 ggggtgtgct ggaacccacc cacaagacag rtatttgtgc ctcttcccag ccccatgttc 60 g 61 <210> SEQ ID NO 713 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 713 gtataccagc aagcagcctc gacacttccc raacttcctc cttgctgaac tgcatcacgt 60 c 61 <210> SEQ ID NO 714 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 714 gtcacgattc cacaaagaca taatgtcgta rtgtcaaggg tactgtgggc tcctagggga 60 g 61 <210> SEQ ID NO 715 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 715 gcaaacattt gtttactacg aagcatcgga sttgaaatgg aggggacagc ctggccttgg 60 t 61 <210> SEQ ID NO 716 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 716 ttcacatatg gaagcttccc aacccgagat yggtctaaat gcagaaactg gaactcacag 60 c 61 <210> SEQ ID NO 717 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 717 aggtaggtgg gggcataaag gttagccaaa sttgaaaata aatatttggt tcactatcat 60 c 61 <210> SEQ ID NO 718 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 718 gtgtgagcgg caaccgctgc tcggaacgag ycattccaac aagacacaga ggcgaactgg 60 c 61 <210> SEQ ID NO 719 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 719 aaatgaggca gcagcatcat ctgcacccct ragctaagca atcatttcgc tggtgccccc 60 c 61 <210> SEQ ID NO 720 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 720 gcagtccttc aaggtagcac ccgcccggtc ygattgggtg caggccgagc caggccctcc 60 a 61 <210> SEQ ID NO 721 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 721 tagaatctgt gaaaggaaaa tagaaactca kgaccacagt tcattatgct tgaaagaaaa 60 a 61 <210> SEQ ID NO 722 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 722 aagagacaaa tgtatgggag cagcagaata yttaatcact tttctgatgt gtgcagatac 60 g 61 <210> SEQ ID NO 723 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 723 gtaatcgttt acccaatctc ctataaaaga yacattgttg tttctcttgt ttccatttgc 60 t 61 <210> SEQ ID NO 724 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 724 agatttgaca ccactctgcc ttcgtcttct ytgcaaatac atctgcaaac ttcttcttca 60 t 61 <210> SEQ ID NO 725 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 725 ctcaatgctg ttgaggagcc tcccagccta ygaacctggt attccagggt gccaagagtc 60 t 61 <210> SEQ ID NO 726 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 726 tcctgaggga agctaggagc cataatctgg raagctttaa gacaacctct gttcacagta 60 a 61 <210> SEQ ID NO 727 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 727 ttttaaaaag aatcagagtg tgttcagaaa rgggacattg cctatagata ttagatattg 60 c 61 <210> SEQ ID NO 728 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 728 catgattatc tttgtataca gcctgttctg maactcacac atagtaaata ctccataaat 60 g 61 <210> SEQ ID NO 729 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 729 taattcagga tcatttctcc acctggagat ycttcattac acctgcaatg acactttttc 60 a 61 <210> SEQ ID NO 730 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 730 agaatgagtt atatcctcaa ttggtgacaa wctttctctt ttttttttct acttctattg 60 t 61 <210> SEQ ID NO 731 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 731 tacatatacc ttcaaggatt tcagtgaagg rcttctttct aactttcctc cttaagataa 60 c 61 <210> SEQ ID NO 732 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 732 tcatataatt acagtagaaa ctctcttgtc sagtccaatt tggatttgtt agttgattgt 60 a 61 <210> SEQ ID NO 733 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 733 agcactctga agcctgtgcc ggctcaaggc kgtttatgga tttagggtgc cctgccataa 60 a 61 <210> SEQ ID NO 734 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 734 caattccaag gcatattaaa aagtcatgat yaaaggggct taccacatga agtacaagaa 60 t 61 <210> SEQ ID NO 735 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 735 actcacacgc ctcatgctat gttccgtaaa yacgttctca gagtaacact gaataaaatg 60 a 61 <210> SEQ ID NO 736 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 736 attgctgttg taattagaaa agcagtgtga ygtagcaaag atgcacggaa gtgcctccct 60 c 61 <210> SEQ ID NO 737 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 737 aataagatgg acttattgga cataatcatc rccatttaaa atgatttgga taggtgccat 60 g 61 <210> SEQ ID NO 738 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 738 ttttttaagc tctgcaagtg aataccacat ktcaattgct gccaatgaga cagtccctga 60 a 61 <210> SEQ ID NO 739 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 739 aatttcaggt ttgaaaactc aaaccaacag raagatatca cacctttgta tgtgcttctt 60 t 61 <210> SEQ ID NO 740 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 740 gagcaaccca aatatttctg atgtaaatgg rtggtacaga gagatcttac ttcaagaaat 60 g 61 <210> SEQ ID NO 741 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 741 agtatttctc aagcactttt aagcaaaggt ragtattcat acaagaaatt tagggggaaa 60 a 61 <210> SEQ ID NO 742 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 742 catggataat aattgacata taccttggag rccatttgga atctccataa acgaaagaag 60 a 61 <210> SEQ ID NO 743 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 743 ttaatcatta atattttcca tggatcaata ycctgtagaa gcatgagatg cagcagtgat 60 c 61 <210> SEQ ID NO 744 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 744 cagaaagtaa taatttatat ttggcaggta kttcctgaaa ctgacacata agtaactcaa 60 g 61 <210> SEQ ID NO 745 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 745 gttcacgatc aaggtgccag caagataagg yctcattctg aagtctcttc tcttggcttg 60 c 61 <210> SEQ ID NO 746 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 746 gagtaataat tataattact gcctagttca yttccgtctt tgtgtggcca agattactga 60 a 61 <210> SEQ ID NO 747 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 747 aatttgccta gaaattattt gcagataggc rctttctttt atgcacattt gaaaacccta 60 t 61 <210> SEQ ID NO 748 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 748 aagataagac aatgaaagag aagtcgaagt saggcccggc acggtggctc acgcctgtaa 60 a 61 <210> SEQ ID NO 749 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 749 ataggaagac ctaactgtcc aatctgcata yaaaatggaa ttccagtttg ttaggggaag 60 g 61 <210> SEQ ID NO 750 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 750 tcttcccctc atccccaaga tgcaacattt ytagtgatac caatttgcag gtatttcatc 60 g 61 <210> SEQ ID NO 751 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 751 tctgtatgta ctgaggaaga atgaggcata ygatacacag aaagaaagca gcagagtaca 60 t 61 <210> SEQ ID NO 752 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 752 cctatgcatc caaataactc acatcacaca rtggcttctt tggatgaatt aaaagtatct 60 a 61 <210> SEQ ID NO 753 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 753 caatattaag tttcctgatg tgtaataagg mgagtaggtc ttatgtttaa aaatagacat 60 t 61 <210> SEQ ID NO 754 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 754 agaaagatat gtgctattta agtgtcagag staggattgt ttaggccagt gatttttttt 60 t 61 <210> SEQ ID NO 755 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 755 tctggagcgt gcagatgaag caggcagtca sggtaatgaa gtcggaaatg caagtccaga 60 g 61 <210> SEQ ID NO 756 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 756 ctccagctcc ttctgatatt ctttctaata ygactttgta cctcttaagg aagacattca 60 t 61 <210> SEQ ID NO 757 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 757 gaaacccaaa gtgtttgctg taatgaccag mgagtgtcag tgaaactcct tagcctaagg 60 a 61 <210> SEQ ID NO 758 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 758 tattaacgca gatcgagttg ggaacgcacg stccatttcg acactcatca atgtcagtgc 60 a 61 <210> SEQ ID NO 759 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 759 gtacctcctt tacagtattt acaacaataa ytttgatagc caacaacatt gagtaatttc 60 t 61 <210> SEQ ID NO 760 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 760 ccctgctcca taaagacaga ggcaggacta ygtgggagag tggtcagccc ttcctgaacc 60 c 61 <210> SEQ ID NO 761 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 761 taatcattag ctttggaaag tgagatcttc mtggtaaatg taaggactac actattcact 60 t 61 <210> SEQ ID NO 762 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 762 accaataata ccttattttt ccaagcagtg yttaactata ctgagcacag acaaatgctc 60 c 61 <210> SEQ ID NO 763 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 763 tttactcatc attttaaaag tttcgtatgt sttcatatgt attatgtatg tttccatttc 60 a 61 <210> SEQ ID NO 764 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 764 agtgggagac agtatctgaa acagcctttg rcatgagtat gtttcatttc ttatgagaac 60 a 61 <210> SEQ ID NO 765 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 765 tttcttatgg gggatgggaa gcaactatca rtggcatagc tgggtttgac tttatacttt 60 a 61 <210> SEQ ID NO 766 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 766 cacattccac atagtctgca gtttcctcaa ycactttgca aaactgactg tcagacaacc 60 a 61 <210> SEQ ID NO 767 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 767 ggctctgtca agcctgtaac tgtgcctttc mttgtactat aggtaatgta gaccatgaaa 60 t 61 <210> SEQ ID NO 768 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 768 tctgatcttg cctcttcaca tcagcacatt ratgacatga cacatggacg ttgaggactc 60 c 61 <210> SEQ ID NO 769 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 769 cccctgagaa caaccatgaa ccaccttgta yggttattga tgtaaagccc cagccagctc 60 t 61 <210> SEQ ID NO 770 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 770 agtccccttt aatcagcatc cttacctgtc rtgggtgtta tcttttttct ctctctcttt 60 t 61 <210> SEQ ID NO 771 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 771 taaaagtgca gtgtggagtg agaacacagt rcagcaaatt tttaatgtca gaaagtagca 60 a 61 <210> SEQ ID NO 772 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 772 gaaaatctta ctgaccacat ggatgataaa stgcaaacac ctgtactcca gagataatct 60 c 61 <210> SEQ ID NO 773 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 773 actgagaaaa ttctgatttt cgtcatttag kttattgccc taaattcaag aacattcatt 60 c 61 <210> SEQ ID NO 774 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 774 tacatatctt tgatatacct agcaaggaga yataaattgc tccctgaata gtaaagcaga 60 a 61 <210> SEQ ID NO 775 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 775 ccaagcactg ttttattact tgtgagatta ygttagtgtc ttttagaaaa acacataatt 60 a 61 <210> SEQ ID NO 776 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 776 ttgtctgtcc tctttctact ttctggatac mttgtatgga cctagatgtg gttccaggga 60 c 61 <210> SEQ ID NO 777 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 777 ggcacagtaa aacaaggtac gcacaaattt waaaagagag ctgaagtaat ttttgtaaaa 60 g 61 <210> SEQ ID NO 778 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 778 tttatcttta agctgcattt acctttttta mttgaaaccg caccaatctc ctctttggct 60 c 61 <210> SEQ ID NO 779 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 779 tttgttcaac atacttgctt ttacttgttt ktcacttgga actgttaatg acaagaaata 60 a 61 <210> SEQ ID NO 780 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 780 ctaacaattc agtcaagctc aataacttaa kgtatgtctt tcacaaatat aggttctcct 60 c 61 <210> SEQ ID NO 781 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 781 gtgggaggtg gtctcacagc aggtctttac ragcctcccg tctttctgtg ttctgggaga 60 a 61 <210> SEQ ID NO 782 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 782 ggaaatacac taacacagag tgcacatacc scatctttta agccgagttc cattacggca 60 t 61 <210> SEQ ID NO 783 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 783 ctcacttcta ttttgttact gtccacctta yagctctaaa ggtaggcttc cttctatgct 60 c 61 <210> SEQ ID NO 784 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 784 gtaatttcta tacttctgcc ttgatttttg ygtgaggcct tgtatttacc ctattatagt 60 g 61 <210> SEQ ID NO 785 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 785 agatataaat atacatgaac catgtgaaag ygataaaatg tcttcctgaa agtgaccaag 60 g 61 <210> SEQ ID NO 786 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 786 tacacatgat atatacattg ctaaaaacca yatttgaatc tttcaactta taaatagtaa 60 g 61 <210> SEQ ID NO 787 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 787 ccctcacatc cttttctcta ttactcatct yaggtacagg tagaaatata acaccaatga 60 a 61 <210> SEQ ID NO 788 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 788 tttcactctg tgtcccataa cctgggaaca ytgatatgag gggtggggtc ccaaggaatt 60 g 61 <210> SEQ ID NO 789 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 789 acagttgtca ctgatatatg actttgagaa yatgaactgc tgtataaatg ttaaatgttc 60 c 61 <210> SEQ ID NO 790 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 790 cccttacatt ttacaccaga ggtaagtgtc ytgctccttt catactaatc cttgccctat 60 t 61 <210> SEQ ID NO 791 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 791 atggtgagcc agatttggtt catggactgt ygtttgccaa atctgatcta gagaaatagg 60 a 61 <210> SEQ ID NO 792 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 792 aaaaagctga catgagcaag gagttgagaa rtattcaagc aggatcaaag acagattgaa 60 c 61 <210> SEQ ID NO 793 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 793 atgtaagatt gtgctataga aactacatgg ycacctccat ttctaaattg ttagaatgct 60 g 61 <210> SEQ ID NO 794 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 794 aagatttatt tagtttatta atgaaggaat sacagtaatg gtaaagctgg ctcaaaagag 60 g 61 <210> SEQ ID NO 795 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 795 atatttcttt caagctatga gaatgcaaga ytgtggaatt ttagtaagta gtctatatag 60 g 61 <210> SEQ ID NO 796 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 796 agataatgaa atccatttgg gagctctgga maccttaact ggcatagatt tgagaagcca 60 t 61 <210> SEQ ID NO 797 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 797 cactgtctta tttaatcctc acaacaagca rgtgaggaac ccatggcaca aagatattaa 60 g 61 <210> SEQ ID NO 798 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 798 aaccaatcac agtacattct tcccctagac rcagagattt gtaaaaggga aaagatctat 60 t 61 <210> SEQ ID NO 799 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 799 taaacattac aactgaactc atgctccatc wctttaattg gtgtaatcct tagggcctta 60 a 61 <210> SEQ ID NO 800 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 800 gattgaagag acactgattt gcccaaataa yaggaagagg gggaagcaag taatattatg 60 t 61 <210> SEQ ID NO 801 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 801 atctactgtt ccctctgctg ctgctgctcc yaactcgact ctagagtgcc ttactcgtgt 60 g 61 <210> SEQ ID NO 802 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 802 aatgtaaagg tgttaaatta agacagctag raagtggttt aaacaataag aataaagagc 60 a 61 <210> SEQ ID NO 803 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 803 agcagcctac tgagcagttg tttctacaag yatcataatg agctaacagc aaacctctgg 60 c 61 <210> SEQ ID NO 804 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 804 ctctgtggca ttctggctcc agaagtcaga ygttcaacgc tgcatgaata acctatgcct 60 t 61 <210> SEQ ID NO 805 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 805 aggagcaagg agagccagtc cgattcccca ractgaagca cttggagtcc agtgtttgag 60 g 61 <210> SEQ ID NO 806 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 806 aagcccagtt tcagaattac tgttaactcc raattgccaa ttacagcttg actttgcagt 60 t 61 <210> SEQ ID NO 807 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 807 acttcaagtt gttgcagaag ggatgatgag rttaatggag aacagaaaga aggtgaacta 60 g 61 <210> SEQ ID NO 808 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 808 aatgcattgt ctacatcgga cagaaaagga mccagaagca tcacagactc ttgcaacacc 60 a 61 <210> SEQ ID NO 809 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 809 ttggaaatca tgtatttgca atggtgttct yaaaaattag aatgttaaag agagccaaaa 60 t 61 <210> SEQ ID NO 810 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 810 caaagtgtac tgtagataag gcaacttgta yagacatcag aattgaatcc atttgaagtc 60 a 61 <210> SEQ ID NO 811 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 811 aagaagaata taattcctct agttaaagag mgtgttctga caataaactc taatatgaaa 60 g 61 <210> SEQ ID NO 812 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 812 cagctcctct tggataagat ggtctactga yaggcctatg gtgataaaaa tgagcaaaat 60 g 61 <210> SEQ ID NO 813 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 813 agtgccatgt tctagaggta caggctccaa raagtccaca ttcaaacatg gttttccagg 60 a 61 <210> SEQ ID NO 814 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 814 atgaccttgg tttagcggtc agcaggtagc raggaaagtg atctcaaggg ccagaaagat 60 a 61 <210> SEQ ID NO 815 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 815 aacagttgac ttttctcttt tatgggtgaa waaaggcttt gggtagcata gaagtggaga 60 t 61 <210> SEQ ID NO 816 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 816 ctaagaattt ttaaaaagtg aaatttattg scagtagagt gtgtgatgca gaaagtactg 60 c 61 <210> SEQ ID NO 817 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 817 tgaaatcaaa tgtgcgttga ggtgaaacac rttctgctag aaagctcata aagccatttt 60 g 61 <210> SEQ ID NO 818 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 818 aataggccaa actgaacagg aaacaaactc rtaattgacc gctcttctgt aattataagg 60 a 61 <210> SEQ ID NO 819 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 819 ggttaggttt aggtgaattt tcattcttcc rttttcctaa ttgctaccat aatcacatct 60 t 61 <210> SEQ ID NO 820 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 820 aacgcccttc tctctgtgga ccgggagtct rctgttcacc actctcaccc cagagcctgt 60 c 61 <210> SEQ ID NO 821 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 821 agagagtgtc gatactaggc aacaagcctc ygaacagata gtgttacccg gaacatcacc 60 c 61 <210> SEQ ID NO 822 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 822 acatctcatc accctggaat ccaaacagga rgaaaagcgt gaggcccaaa gcctcttgtt 60 c 61 <210> SEQ ID NO 823 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 823 tctccttact ttcctgtttt actgttctat rtccaggtaa tggtagttac agcagaagtt 60 t 61 <210> SEQ ID NO 824 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 824 actctgttgc tgcaggctca ggtttagacc ytgcctttgc tctgcgcaca tgtccttccc 60 g 61 <210> SEQ ID NO 825 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 825 aaaaactctt ttttttccta ttagaacatc raatacttct acagaatatt tctattctat 60 g 61 <210> SEQ ID NO 826 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 826 agaccctttc tttgggtaag tgtgtataag kttcaacaag ggaaatccat gtatgcatgc 60 a 61 <210> SEQ ID NO 827 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 827 ctcaattgaa agagaggctt gagattacaa sgtgaaaact gtttcttgcc attattctgt 60 t 61 <210> SEQ ID NO 828 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 828 gttctccaca tcagcaatga gactgtctca mattcatatt atttatgtgt tcactggagt 60 a 61 <210> SEQ ID NO 829 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 829 tagcacagtg gaatccctac agacaagcag rgaagatggc tcgaaggaga tgcagcaaga 60 a 61 <210> SEQ ID NO 830 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 830 gagaaggagg agctgaagta aacaccccca wccttgtcag tctttggtta aagactctcc 60 t 61 <210> SEQ ID NO 831 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 831 taaatatact ctttagatgg ctgctcctta ygacaaaggt tttatttggt gatttgatga 60 t 61 <210> SEQ ID NO 832 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 832 ttaaaatgta gaaacctcaa tatcacttgg rttactagca aaagcatata tgacccattt 60 a 61 <210> SEQ ID NO 833 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 833 attataaacc taggggatta tcagtctgca rtaaaactct ttttggactg aggcttattt 60 a 61 <210> SEQ ID NO 834 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 834 atcctttcat gattacttta gagcaggaat rcccaatctt ttggcttccc tgggccacat 60 t 61 <210> SEQ ID NO 835 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 835 gcccactgct tcccaccaat gagttaagta rtttttcttg cccatttctg caaatttgtg 60 t 61 <210> SEQ ID NO 836 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 836 tgaaatatct ttttatctca tactaaaaat rcacgttttg ttcaggtaca ggattgctat 60 g 61 <210> SEQ ID NO 837 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 837 aatctattca aatcttttgc tgttttgtat rtttgagtat tcatcctctt agtattgagt 60 t 61 <210> SEQ ID NO 838 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 838 tttactgaat tcgtgtatca gttcaaatag yttgtttgct aaagtcttta tgttttttga 60 a 61 <210> SEQ ID NO 839 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 839 ggaacttgta ttagcagctt tgaggatgac ragaaacaga atttaagtgc tacactagaa 60 t 61 <210> SEQ ID NO 840 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 840 catgagggtt gcattccctc ttcagttgcc magctttttc aggatgtgag gtcagcatat 60 t 61 <210> SEQ ID NO 841 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 841 gtgggacctt tggagattta tggagtttag rgttacaagt atgatgtggc caccatactc 60 a 61 <210> SEQ ID NO 842 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 842 cctgagttgc aaagcatata caggctgaag yacaatgtca agaaaacatg ttaaagggtg 60 g 61 <210> SEQ ID NO 843 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 843 tgaaaataca gtacatttta gtatttactc wccatgctct tgaggttatt tatgtcaata 60 c 61 <210> SEQ ID NO 844 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 844 tggccgagca gatgtgcagg actgggctaa rgagcagaca ttcacccacc tctgagcaaa 60 c 61 <210> SEQ ID NO 845 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 845 tactcaacat gtaaaggcag agtaggaatg rgaaagacta gggaaataag aagatcagaa 60 a 61 <210> SEQ ID NO 846 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 846 gaatctttag attgctttgg atcgtacaga yattttaaca acattaattc ttcctatcca 60 t 61 <210> SEQ ID NO 847 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 847 aattcacact aaaaatgact agatgaaaga ygtggtacta gaggctttgt atatgcctag 60 a 61 <210> SEQ ID NO 848 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 848 gaggcatctc tgttttaaca agtccagtag kaagctcttg accaccctac cttacaaacc 60 t 61 <210> SEQ ID NO 849 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 849 tctgcctggg aagccttccc ctgatacccc yagttggcag gagtcttcat ttgttctttt 60 c 61 <210> SEQ ID NO 850 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 850 agccttctca tgctctcttt tacctaccac wtctgactga tagccaggcc ctgctattta 60 t 61 <210> SEQ ID NO 851 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 851 tgaagtccat cccgatctga aggttcaccc rtcactaaga gacaaatggt gcttctgtta 60 a 61 <210> SEQ ID NO 852 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 852 ttagcaactt gcacaaccat tgcactatgc kcattgattc tgtgagtcgg aatctggaat 60 a 61 <210> SEQ ID NO 853 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 853 tccaggcttg gctggaatga tccaatactt sctatgattt tatcctcatt agccactcaa 60 c 61 <210> SEQ ID NO 854 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 854 tatctctccc caggactgga ctctgagccc rtcattgaaa tgagagacca cgaggacggg 60 g 61 <210> SEQ ID NO 855 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 855 atcttccttg gattatcaaa tgtgagtctg ycattgattc ccattgagac cctccctgat 60 a 61 <210> SEQ ID NO 856 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 856 ttaaatgaaa gtggacacac catgactgga ratactatag gacttaattt taagaacaag 60 c 61 <210> SEQ ID NO 857 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 857 ctgagtatct tactacatat tttacaaaag rctcattgtt tcacagtgtg ttattagaat 60 t 61 <210> SEQ ID NO 858 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 858 caggaggcca gtttggatct gaaggtggta rgtaagaatt ctagatagat attttgtatt 60 c 61 <210> SEQ ID NO 859 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 859 tccagcataa gtgaaaaaac agtgtttcgg rtacgctagt gtttctgaga caaaatatgt 60 a 61 <210> SEQ ID NO 860 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 860 ttttgtgatc atgcattttt ctgtaaagag ygcccacagc tttcattaga atttatgtgg 60 t 61 <210> SEQ ID NO 861 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 861 aattgcaagc caatatttat aaccactgta maacgctgcc ctcattcttg acagggacaa 60 a 61 <210> SEQ ID NO 862 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 862 caatgtagtg ggtcatgccc agcattgaaa mataatgaaa gagtagagag cagaatgaaa 60 t 61 <210> SEQ ID NO 863 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 863 ccagaggaac aacagactat gtgtcactgg rccaaatgag ataacacctg tgaaggtcct 60 t 61 <210> SEQ ID NO 864 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 864 gagtgctgag tcagagcctt aaaaggatgg ragttaagag caaaaatggg tattcctggt 60 g 61 <210> SEQ ID NO 865 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 865 gtacaattag ggaaagcata acccagttga rcatgaccct cctaaaattt gctttcaaaa 60 t 61 <210> SEQ ID NO 866 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 866 aggtgatgtg ataccgcacc ctgtagatat ytatgcctgt caagtattca taagcactct 60 t 61 <210> SEQ ID NO 867 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 867 tggaactttg ctcatgtctg cgtcagtgga rcctagacct ggaatctcaa ttgtgtgatt 60 t 61 <210> SEQ ID NO 868 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 868 tctacatcta ggctctattc tgtcctattg ratgtactgt ttatcccttt gccaataata 60 t 61 <210> SEQ ID NO 869 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 869 attcaagttg ccatggcaaa ttacgataga rtggttggct actaaactac agaaatttat 60 t 61 <210> SEQ ID NO 870 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 870 gttgaaatat caatagcttg attttagaca mgataaatct gaggtgccta ttagacatca 60 t 61 <210> SEQ ID NO 871 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 871 cagcaaatat gggtgtgtat tggctgctac raaggaagtg tatgcctgaa ctatttgcta 60 a 61 <210> SEQ ID NO 872 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 872 tgactctgag ttttgatgat tattccaact rctttcagaa acaataaatt ctaatgggct 60 c 61 <210> SEQ ID NO 873 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 873 acttgatggg aaatgttctt agcttcaaat rtaaatgggt cctcccttta gctaaattcc 60 t 61 <210> SEQ ID NO 874 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 874 gtttatagca gatggaaagg cgaatatagc stgcttttcc acataagagc ttgtcaggta 60 g 61 <210> SEQ ID NO 875 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 875 agctctctga gctccatttc ttagcatttg sctgttcttt gtaactttaa taattgatct 60 t 61 <210> SEQ ID NO 876 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 876 tgtcctgcta ttgtttctta agtgccaata sattaataca atatagcagg gctcacacag 60 c 61 <210> SEQ ID NO 877 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 877 ttctactttg ttttagaaaa tgaaatggcc raatgaggat agagagaaaa ttaggaacat 60 c 61 <210> SEQ ID NO 878 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 878 gatttttact tttagctatg agtttacttt ygtagaagta ggcataatat taaatcagag 60 a 61 <210> SEQ ID NO 879 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 879 gcccagcgaa tccggatctc ctgtgtatgt saaccaagtc aaagtgcgag tctccgacgc 60 c 61 <210> SEQ ID NO 880 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 880 tctattgtaa attgaccaga acaggaatac rtttgtgaat tcgtaacgta agaaggtagc 60 a 61 <210> SEQ ID NO 881 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 881 taggacttcc agtactaagt tgaataaaag yggtctctcg tcttctcttg ccatcttcct 60 t 61 <210> SEQ ID NO 882 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 882 ctgtgtatta catatagaag tactgtatat rgtgaggaat gccatcctgt gtgtgttgtt 60 a 61 <210> SEQ ID NO 883 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 883 tcctccctgt cctcacactt gaacttcatg rtccaatcac ttcaataatt atcttgtcct 60 c 61 <210> SEQ ID NO 884 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 884 aagacagccg cataagccat cggcaggaat yaaggtacag gaagggcttc ctggggtact 60 c 61 <210> SEQ ID NO 885 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 885 cctcctatag tcaccttgca agtccaggac rgaaccagaa ttgacatctg agcctcctac 60 c 61 <210> SEQ ID NO 886 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 886 ggggccttgt cggctattgc tgaggctttg ktttttactc tgagtcaact gggaggcatt 60 g 61 <210> SEQ ID NO 887 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 887 actgtttaag tgtttattaa aaagtagagg raaagttgag aaattagaaa taaataataa 60 a 61 <210> SEQ ID NO 888 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 888 gaagacagga gaagctcctc aacacaggga wagaattagt gagtaagagt cctcagggga 60 t 61 <210> SEQ ID NO 889 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 889 ttatctgcta ctcttgtctt atttcatagc mattgccata gctggagact tcattatctc 60 a 61 <210> SEQ ID NO 890 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 890 gtttcagcag attctgggta ttaaaaaact rgaacaccag ctcctttata atgcatgtca 60 g 61 <210> SEQ ID NO 891 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 891 ctactgagct tccctgagtt ccaccttgag rtacaacttt tgcagaaatt agggtacaga 60 t 61 <210> SEQ ID NO 892 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 892 agccacctaa gtggcagaaa ggatttgagc kctggcaata taggtacaac ttctgcacca 60 c 61 <210> SEQ ID NO 893 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 893 tgctacctag gcagacacca ttagttgtac ytcataccaa ttcaccactt cttacatggt 60 a 61 <210> SEQ ID NO 894 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 894 tttttcaatc ttcttacctg ttaccactct ycttattttc catagagctc tgattgtcat 60 c 61 <210> SEQ ID NO 895 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 895 agaatttata ggggaaacag taccatttct rcatgacttt catttgcatt tgtttgttat 60 t 61 <210> SEQ ID NO 896 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 896 ccttcttagg tcctgaatag tccttaggtc rttagcagtc tgactgagtc ttctcttact 60 g 61 <210> SEQ ID NO 897 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 897 gtttaccaga attttgctta agtcatacta yggacctttc tgacttgaaa tcattttcga 60 g 61 <210> SEQ ID NO 898 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 898 tagtaggtga tacagacaac aaattgacag ragctaatga aagcggtaca ctggaaatag 60 t 61 <210> SEQ ID NO 899 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 899 cagccttggc tcttgcctag tagcgggcct ktgtagaaaa tcaaaaggga aaatgggaca 60 g 61 <210> SEQ ID NO 900 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 900 gacaaactta aaaatcaagc gagatgcatt yccctagtaa atccctgttt tcctagtcct 60 t 61 <210> SEQ ID NO 901 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 901 atatatgatt cataagatgt cttacgtttg ycggttctaa acatccttta tattttatca 60 t 61 <210> SEQ ID NO 902 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 902 aaaaaatgac ataaatagat tctgatgttg yttcatttct gcagaagggt gtttttatat 60 t 61 <210> SEQ ID NO 903 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 903 acaaaaatac tagaagaaaa tctagggaaa wctcttcagg acaaaactct tctagacaat 60 g 61 <210> SEQ ID NO 904 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 904 taatttcatg actttaaaaa atgaagctct maccttgaga tagatatctt tccaaaactg 60 t 61 <210> SEQ ID NO 905 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 905 cactctcttc cagtttctgc taatgctact rctattgctt actacattat ccaagttgga 60 a 61 <210> SEQ ID NO 906 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 906 ttgtaattga ttggtcaggt attttatagc raacttctat gtagaatata ggattagata 60 a 61 <210> SEQ ID NO 907 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 907 gtattaaaga gagtgttctt tttactaaag ktatcgtctc ttggttaatt acttctgttt 60 t 61 <210> SEQ ID NO 908 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 908 gaatatattg aatttatagc tttctaagtg raaatttgcc ttcttatttt gagattttat 60 t 61 <210> SEQ ID NO 909 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 909 taatgacatt tcagtagtcc ttatggggtc wcaattgctc tatttttttt tttattttaa 60 a 61 <210> SEQ ID NO 910 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 910 catgcagata cctaaataca atcatttctc rctcaaagat gggggtatct tttgagaaat 60 g 61 <210> SEQ ID NO 911 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 911 catgtcattg aaaaaatgtc caacagcata rgactaagtt gagaattggg gagctatacc 60 t 61 <210> SEQ ID NO 912 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 912 tgtttaatgt ctctgctctg aacagatttc rattcttcaa gaggaaatca tatggcaatt 60 t 61 <210> SEQ ID NO 913 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 913 tctcttaaat ttaatagtga taaaaagcta rccctgattt tcctaggggc cagagtaaat 60 t 61 <210> SEQ ID NO 914 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 914 ttgtttcctg gaaaatggaa ataatatcag yaatgctgcc ctggccaggc acggtggctc 60 a 61 <210> SEQ ID NO 915 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 915 taaggggcca tataaatcat agaatttaaa mcacgttgga gtaagtactg aaggaaaacc 60 c 61 <210> SEQ ID NO 916 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 916 aagtgagggg atcctcaagg cttttaattg rgctagcaca gcaataattt gacaatatga 60 a 61 <210> SEQ ID NO 917 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 917 agatgcacag ctgatgaaag gtgaaactga yattctagcc catgttcagc cagttccaaa 60 t 61 <210> SEQ ID NO 918 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 918 cttctatccc cgagtctaga ctctaccccc rcaatcttgg atgggagtgc tggaggccca 60 g 61 <210> SEQ ID NO 919 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 919 attattttct gttacctata aagccaatgg yatcagaaag tacacaaggt ttgaatgcaa 60 t 61 <210> SEQ ID NO 920 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 920 gtgggtgtca cccatacaga attggagaaa rggttatatt ctgcttttgc taatgattta 60 t 61 <210> SEQ ID NO 921 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 921 gatggttgtc ctcaaagcag ccagcatttt katcaggctg gcgtctggtc ctgtattttt 60 c 61 <210> SEQ ID NO 922 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 922 ctaggcacag tacactttga tcgttttccc raaaccgcgt tggacaccat ttttccatga 60 t 61 <210> SEQ ID NO 923 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 923 tggcagactg acataactgg atgtgactat kgttatagct ggtgggacag actcctatcg 60 c 61 <210> SEQ ID NO 924 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 924 taaagggctg ttcttgactg caggcagagc ygatttctga acatggactg tggggttctt 60 t 61 <210> SEQ ID NO 925 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 925 agagagagag agagagagag attagatgga yaggtatgta gtttcaccta taagcaaagg 60 c 61 <210> SEQ ID NO 926 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 926 ttggagaata ttatcactta ctgtactgtc rcaaatttca gataagttaa cattcctgaa 60 t 61 <210> SEQ ID NO 927 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 927 tagagggagt tacattttgt tgaatttaga ragcaattta tgtggatgtt accatattca 60 a 61 <210> SEQ ID NO 928 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 928 cttttagaac ggtgctgcca tgagttatga ytaaccgaga aaaatgtatt ctatagccaa 60 a 61 <210> SEQ ID NO 929 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 929 cagtagattg caattagagt ttacttgatt wggcaattat taaaaaatga acattttttt 60 c 61 <210> SEQ ID NO 930 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 930 gtgagtctgt attcaatttt gctcagagaa yatttgaagc actcaatatt taatttctta 60 t 61 <210> SEQ ID NO 931 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 931 tatatattca gtatatcatt ttatatttga scaaaatcac aaatctatta atattgctaa 60 g 61 <210> SEQ ID NO 932 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 932 gcaagctctt gatgcataga ctcacaagca raagtctact tattgagata ctgtgttgat 60 a 61 <210> SEQ ID NO 933 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 933 aaatcatccc tgccattttt cctattcaaa yatgttctgg tatctactaa cacaactgta 60 t 61 <210> SEQ ID NO 934 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 934 caaaggcagc ctcacacttt tctgctcagt rttcagttga cacctgccct tgttttgctt 60 c 61 <210> SEQ ID NO 935 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 935 acaactcttt cttcaggaaa cctttgactc rtggtttata catacttttg tattaagttg 60 t 61 <210> SEQ ID NO 936 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 936 agtggttgtg tgtatatctg agaagagaac rtaccaagca gagaaaacaa caaaaatcaa 60 a 61 <210> SEQ ID NO 937 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 937 tttggtagtg caattgaaga ccacataaaa mtgctgctag aatgcatctc ctttgttagc 60 a 61 <210> SEQ ID NO 938 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 938 gtgcactttg gaagttcact gcatttaatc rattcagagg atttcttttt tttttaattt 60 t 61 <210> SEQ ID NO 939 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 939 ggtaaatctc ttcttaaatt aaaacacaga ytatgttaca gcaagtcatt aagagtcata 60 a 61 <210> SEQ ID NO 940 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 940 ctatcatttc ttttccaaaa ttacttctct ytatctggaa tttaattaat cgaaatgaat 60 t 61 <210> SEQ ID NO 941 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 941 gctgcttcca aaaccaaaca ttctcttact rtgtgatcca gtgattacac tccttggtac 60 t 61 <210> SEQ ID NO 942 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 942 acaggttata acagcttgca ttgcattccc sctaatttga gaatttctat gtcctcatca 60 a 61 <210> SEQ ID NO 943 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 943 aaaaaaaaaa tcaaatatca tctgtttcta yaaatcaagg cctgaatatg tgtatttaca 60 t 61 <210> SEQ ID NO 944 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 944 ccattactat taaagtgtaa ctttttctca yaccagcttt ctaatttatt gatcttcttc 60 t 61 <210> SEQ ID NO 945 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 945 caaagaaggt gtccacatgg catgtaagca ygtgaaagat gctctgaaca ccatttgtca 60 t 61 <210> SEQ ID NO 946 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 946 ttggattttg ctagtgatac ttaactaatg rttcatactg tatttgaagt gtctgctgcc 60 a 61 <210> SEQ ID NO 947 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 947 cttaaacaga aaataatttg ttcaaagtca sagtgtcaaa ccaggattaa acccaggtat 60 a 61 <210> SEQ ID NO 948 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 948 ggtatatagg atacaataat ctgtgcattt racgacaaca gtactattta ctcatgacat 60 g 61 <210> SEQ ID NO 949 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 949 atttgtaact tggcctatca gtttgagacc yttgttctag acactttgta tactgtctca 60 a 61 <210> SEQ ID NO 950 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 950 taattaagcc acaaagcaca atgcaagttc rataatcact ggaaataata tgccttttaa 60 g 61 <210> SEQ ID NO 951 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 951 attgaacttg gctctgaagt aaaacaatac rggtttttga gtgatccagc agctgttcta 60 c 61 <210> SEQ ID NO 952 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 952 gggaaagaag aaaagattcc gtatttttta ytctggcttc cttgagcaca gctttcttct 60 c 61 <210> SEQ ID NO 953 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 953 tcttgccatt ttgcttaatt gtatgattat stgaaagtag gaatagaatc ctttgaactc 60 t 61 <210> SEQ ID NO 954 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 954 ccagtgagcc aaattttaag taaacagaaa yggaaggtgc taagcaaaca aactccagcc 60 a 61 <210> SEQ ID NO 955 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 955 ctcgcaagga ctgtttacat ctaacattgc htagatctga aataaataac actaggagga 60 a 61 <210> SEQ ID NO 956 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 956 cctttgtgaa ttaatattaa cagataaagt rgagatccga ggcacttaca tgagtaaata 60 a 61 <210> SEQ ID NO 957 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 957 ctcaccttcg tggttgacct tgtagtgcag sgtgacgggg ccgctgcacc tctggatggt 60 c 61 <210> SEQ ID NO 958 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 958 actatattag acattacgga gcatataaaa kaaggcaagg agctgtcctt gaggagctga 60 g 61 <210> SEQ ID NO 959 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 959 gtcttctcat aattgaagtg gttgtcgttg ygtgtgaggg cagcccttcg aaccagggag 60 g 61 <210> SEQ ID NO 960 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 960 gaaaaaaata agaggtgttg agtgatgctt ycagaaagtt tccttaaact taaaggcata 60 a 61 <210> SEQ ID NO 961 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 961 aactaacaga gcaggtatat gcctgttaga ycttagctgt ggggttcctt tactattggg 60 t 61 <210> SEQ ID NO 962 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 962 agctctgcag tccaccacac ataagcacag ygcatggaaa atgggaagac agcttcttca 60 g 61 <210> SEQ ID NO 963 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 963 cagattcagt agtatgtgat gtgccaaaga yagttttgga actgagaccc ggagtcacag 60 c 61 <210> SEQ ID NO 964 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 964 agaatgtaga tatgagacag ctgatctcta sgaactgaat ttttagtgag taaagcaagc 60 a 61 <210> SEQ ID NO 965 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 965 gcattctaca tggccactgg cattggcaca mataggtttg gcacataccc tctttgtgtg 60 g 61 <210> SEQ ID NO 966 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 966 cagaacaatg tgtcactacc agaaaccatt ygctatctct gttccttgtt tgtatttctg 60 c 61 <210> SEQ ID NO 967 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 967 tcagtcctga ctgcctctct gtgctcttca sattgacctg cttcagttgt ctctatcatc 60 g 61 <210> SEQ ID NO 968 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 968 aatgcattgg cttttacttt ggatactccc rcatctagga gatatgggag cctttggagg 60 t 61 <210> SEQ ID NO 969 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 969 aaagtcccag atggaaaccg agaccaagta ytttgccacc atctgaggat tagaggctgt 60 t 61 <210> SEQ ID NO 970 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 970 tcccatttag gtaatatagg ataatttcct ygtctaaaga tccttcactt attcttattt 60 g 61 <210> SEQ ID NO 971 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 971 ggttaaatgt gtcttgattt gaatggatat rgatggcgtg attttggtgt ttctgcccca 60 a 61 <210> SEQ ID NO 972 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 972 gtcctcccct ccaaataccg tgggaataga rctgcttcat catgtccctg tgggcaccgt 60 t 61 <210> SEQ ID NO 973 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 973 agggtgatat tgcaaaagta ttatcaaaga ragcatatga cagggggagt ggagatttgg 60 a 61 <210> SEQ ID NO 974 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 974 gataaaaaca aaatgcacag caaggctcgt rtagttaact acaggttctc atgagtacag 60 a 61 <210> SEQ ID NO 975 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 975 ctcaaaccag tccagcaagc agggactata ragtgaggta gcaggaaata aggctggcaa 60 g 61 <210> SEQ ID NO 976 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 976 cacgagggca gggaaataac agggctgata yggaaacagc tgtgggcaag gcaaggccca 60 a 61 <210> SEQ ID NO 977 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 977 agaaaacccg aagtcagagc ttagtttggc rtacattttg ttcagcaaaa aacattattc 60 t 61 <210> SEQ ID NO 978 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 978 caacagaaga gctttttctg gtattttcgc rtgttctcta ttggtttggg ggaagaatcc 60 a 61 <210> SEQ ID NO 979 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 979 ttaacaatca tcatgctaaa tcatgcctag ycatgaaaga gtttttggtt gtatgcttta 60 a 61 <210> SEQ ID NO 980 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 980 tggaatacat ttaaacttct caggctggca rtaaatctca ggccaattta tttagacaac 60 t 61 <210> SEQ ID NO 981 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 981 ttgataaata aaaacttctg gtttaagtag rgaagaagat gttttaaggt cggttcttgg 60 a 61 <210> SEQ ID NO 982 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 982 ccttcagttc ttgggaactg tgaccgactt yctgtcatgc tggtccatgt agccacccat 60 t 61 <210> SEQ ID NO 983 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 983 atcagtaatt cactttctcc tcacaggcaa rattaagtct atcaatacag tactcagaag 60 t 61 <210> SEQ ID NO 984 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 984 aagtaatttt aactttgtgg aacatgactc kgaattgggt agtagactgg ggcttagttg 60 t 61 <210> SEQ ID NO 985 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 985 cctaaggtcg gtttcttcct ctgtagaatg sggatgaaaa tagaaatcac atcacccggt 60 t 61 <210> SEQ ID NO 986 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 986 cctgttttca ctcatctctt cctttaaccc rgattccaag aaagcttgac aactgtctac 60 a 61 <210> SEQ ID NO 987 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 987 gtagaagttg aaaggaaaaa ttggtctgaa stgtacttaa tccaaaactt aacttgaagt 60 a 61 <210> SEQ ID NO 988 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 988 gaaagtcctc taagaattgg aatgcttgga ytgttaaaag tatccactga aaataaatta 60 a 61 <210> SEQ ID NO 989 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 989 tgaaagttac ctattaggta cagtgtccaa ygtttgggtg atgggtaccc cagaagccta 60 a 61 <210> SEQ ID NO 990 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 990 ctgaccctca atcggaatga ataatgagac kttcagctat ctccctgagg aggtgtgttt 60 t 61 <210> SEQ ID NO 991 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 991 ttgaagaaag agtttcacat cactaaaaaa ragtttggag gcctgtgttg aacggcagca 60 g 61 <210> SEQ ID NO 992 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 992 ccacaggtca cctaaaccca actcttcata ygtcttccaa ggaaccacgt cgctaaacaa 60 g 61 <210> SEQ ID NO 993 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 993 actccgcggg acacgaggac acgggacggc rtctccagaa ttgcttgtta cgtaggaagc 60 g 61 <210> SEQ ID NO 994 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 994 atctatcaat ctatcatcta tctagtctat mtacctactt atctctaatc acccaccaaa 60 a 61 <210> SEQ ID NO 995 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 995 ataccagtcc tctgaacact tacagaaccg rcttgctgct catcacatac aacacgtgat 60 a 61 <210> SEQ ID NO 996 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 996 tgggctgctt aataaccttc ctaacattcg rcattatttc tactttctag ccagaacatt 60 c 61 <210> SEQ ID NO 997 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 997 ttttttctag attgtcaggt ttttagcagc rccatattat ttctagtatc cttttcttat 60 c 61 <210> SEQ ID NO 998 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 998 gagtcaccct ggtgtctgtg accaaggaat wtgagggcca caaggctgtg gtccaagacc 60 t 61 <210> SEQ ID NO 999 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 999 taaatgcctg gaacaagtct gtcaaaaatg rtaatggctt ttctcactta cagtgggatt 60 g 61 <210> SEQ ID NO 1000 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1000 cataagctca ctggactctc agggcaggga rgaagatgct gtaggaatat ggaccaagca 60 c 61 <210> SEQ ID NO 1001 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1001 aattctgggg cttaaacaag cacattccaa rttaagaacc aatgacctaa gggaatgtct 60 g 61 <210> SEQ ID NO 1002 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1002 ctttatttaa actctcaacg attcagttct yttatctgga atgtcaggac agtaagggtt 60 g 61 <210> SEQ ID NO 1003 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1003 ggatatcaca caaagacaaa aaatccccac saaagaggct cacaatagaa gggacagtga 60 c 61 <210> SEQ ID NO 1004 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1004 gcacagcagg aagacagggc gctagggacc rgtttctacc tttgcttgcc tagagtaacc 60 a 61 <210> SEQ ID NO 1005 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1005 attgggcata caggtaggga tcccagtgtc rgaggcattt aacaagagga actccatctt 60 g 61 <210> SEQ ID NO 1006 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1006 agaaaagggc aaggggtaat gggagcaaag saaagttcca tgaaagtcta gatcccagat 60 g 61 <210> SEQ ID NO 1007 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1007 cacaaggaag gtataagcca gaggattact rccatgctgt cattccccgg gaaaattggg 60 t 61 <210> SEQ ID NO 1008 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1008 agaacacatc accatccaaa gaaagaacag ytcctctggc agcttccttg caaggaagag 60 a 61 <210> SEQ ID NO 1009 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1009 gatgttgatg tatatttttg acatgaaatt wtgcttatgg tacactatta ggttaaaaaa 60 a 61 <210> SEQ ID NO 1010 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1010 acagagtctt taagaggtat gaaggaattg ytgtaggcca acagcatgtg gctcttaata 60 a 61 <210> SEQ ID NO 1011 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1011 ttgcctattg tctctatact gaactactga rctgtccttt atagcaatct ccccctcatc 60 c 61 <210> SEQ ID NO 1012 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1012 cttttgtgag ctgatttatc agcaaacctt sagaaggtga agcagaagtt ttttccttgg 60 t 61 <210> SEQ ID NO 1013 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1013 tgaaaaacct ctccatatgt ttctgatttg ycaggcaggg agaaccagaa aaccttccta 60 t 61 <210> SEQ ID NO 1014 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1014 acggcagggg cacacatggg ggctccctca kctggggatc tctcaggctt ttttcactct 60 c 61 <210> SEQ ID NO 1015 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1015 ttcactgact gtctttgctt cacagattcc rcttttgcta gatcaacaat acatcttgtt 60 t 61 <210> SEQ ID NO 1016 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1016 gtttaatggg gaccgtttca gttttacaaa katgaacggc cgtgatggtt gcacaaatta 60 t 61 <210> SEQ ID NO 1017 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1017 tggaatgctt aaaaaaagca ctgatagagc ragaaaatac ataccttact cacctgctac 60 a 61 <210> SEQ ID NO 1018 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1018 tgggggaagc acctatttac ttcccgttcc rtttcctagc tgtaagctct ctttccagca 60 g 61 <210> SEQ ID NO 1019 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1019 tgccctagaa aaaattacgg aaaggtaaag kctgtccttc cctgctgtgt gacagatgct 60 t 61 <210> SEQ ID NO 1020 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1020 gagatgttag ctaaaggata aaaccatcac mggaagaata agttcaagag atctattgtg 60 c 61 <210> SEQ ID NO 1021 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1021 ggactatgaa catgagttaa aaatgtgaca rtataatagg ccaaatgtct tttacttttg 60 a 61 <210> SEQ ID NO 1022 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1022 tcaaataaac atttagtgag atcagtaaac rgtcagtgtt cctaaaaagt acacccaaat 60 g 61 <210> SEQ ID NO 1023 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1023 gttatttatt tttggagttc tgttaggtta ygaaaatggg ctaggcatgg tggctcacac 60 t 61 <210> SEQ ID NO 1024 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1024 ttggaaagca tctaattcct cttagcacaa ygtaagtaac aaaaaaaatg catgtcttac 60 t 61 <210> SEQ ID NO 1025 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1025 taagatgaga atttatttct ttcagtttga yctcttggta tttattgatt ttggaacatt 60 a 61 <210> SEQ ID NO 1026 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1026 agctcatctg atcctcacaa ccaaacatca mtgagttgga tagtatcccc atttaacaga 60 a 61 <210> SEQ ID NO 1027 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1027 aacctttata atgcccttca atggaaattt wtgtcaagta aattcaattc aagctatgat 60 a 61 <210> SEQ ID NO 1028 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1028 tgacggtaga attaagtttg aggaagattc raggatatgg attaaacagt cattcttctt 60 a 61 <210> SEQ ID NO 1029 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1029 cctaaaccaa ttactttcat accaggaaaa kcctttctag caccagcaaa atcccaccca 60 t 61 <210> SEQ ID NO 1030 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1030 ttttccgggt tgataggttt ttttggcaat ygaaatccct atttaacaga tttaaataaa 60 g 61 <210> SEQ ID NO 1031 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1031 ctgaataaag caagttgctc tccttaatgt sgtgggcctc attcaattag tagaaagcct 60 a 61 <210> SEQ ID NO 1032 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1032 ttagcaggag gatgcataac agagcggtat sttcaataac tgccaggttt ctgacatggg 60 c 61 <210> SEQ ID NO 1033 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1033 tgctgtccaa aagaaatata acatgagcct matatggaac tttaaatttt ctaataacta 60 c 61 <210> SEQ ID NO 1034 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1034 cacgtctact gattaaacac attaaacttt ygttacaaat ttcaatcaat ttataaaaat 60 t 61 <210> SEQ ID NO 1035 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1035 agtctccttc cagaaagcag tcaagcttaa ygaaacaagg ttgtttcctg agttccgaag 60 g 61 <210> SEQ ID NO 1036 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1036 ctgaggcata gagcggttaa gttacttacc raaggacaca aaattagtaa gtggcagagc 60 a 61 <210> SEQ ID NO 1037 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1037 gatcatatca gggaaatagt ggcctcatac kcatttgtat caccgttgga catcttgtaa 60 g 61 <210> SEQ ID NO 1038 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1038 ttgcaaatga gaatttatgg tggccacaat yagtactaga agatcaatta aataaatgga 60 a 61 <210> SEQ ID NO 1039 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1039 tagagctaat ccattattca aattttgtca rgaaaatctg gatgaattgt gtaaaactgc 60 c 61 <210> SEQ ID NO 1040 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1040 aaaattacag attgtctgat gcaactccat rtctactgac tgacgaattt caaagcatag 60 a 61 <210> SEQ ID NO 1041 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1041 ttacaattac agggtgattg gcgcaatgat rgaggcactg acaggagcaa gagaaaactt 60 c 61 <210> SEQ ID NO 1042 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1042 tttaaaagtt acacttgaaa taataggcaa maaacactga tccacattcc aactggtagg 60 c 61 <210> SEQ ID NO 1043 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1043 gataccacct tggagtgtta tcgaggtgag mtgtgctaga taaatcaatc aatacctgaa 60 a 61 <210> SEQ ID NO 1044 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1044 ttttgaaatg aaacataaag tcaggcataa yactaatcta gagtactcct gcctaggatc 60 a 61 <210> SEQ ID NO 1045 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1045 gatttgttgc aaagtctttt gcttaatagg mtactaaaca ctgaaaaaga caataattag 60 g 61 <210> SEQ ID NO 1046 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1046 atgattaatt acaaatagta gtgtataaac ygcacatatc gttttatttg cttcacacaa 60 t 61 <210> SEQ ID NO 1047 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1047 taggatactt attaagatgt cactcctcgc rggattgtgt gaagcaaata aaacgatatg 60 t 61 <210> SEQ ID NO 1048 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1048 gaggagaata tttgtatttg gaagaaacag ytatactttc aacttatttc agaagaaaat 60 a 61 <210> SEQ ID NO 1049 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1049 gtcctagtat gttgttaaaa ttgtctgtta ytctaagttt ataagaagga tcaatgatgt 60 a 61 <210> SEQ ID NO 1050 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1050 tgtgtttttt gaggaatcgt ttttttctac yttgccgaat atatgcatgt atagttgttt 60 g 61 <210> SEQ ID NO 1051 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1051 atttatatcc atctatctaa acctatctat ycaaaaactg tgtcaacaat gttgctcaat 60 t 61 <210> SEQ ID NO 1052 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1052 gtgtgtagtg tgaggcaaag ctgtgtctgc ygctaaagtt accctatgga gcattatcct 60 c 61 <210> SEQ ID NO 1053 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1053 accctatgga gcattatcct cagctgaaaa ratgtcagga ttctggaaaa ccaaaacaat 60 a 61 <210> SEQ ID NO 1054 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1054 tgtctttccc cactcaactt actgctcacg wagaaagatc agtgtcagct gttggcaaga 60 t 61 <210> SEQ ID NO 1055 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1055 aggaactatt caagatagcc tcgattcatg wcctgaatgt gtgtagataa atttataata 60 t 61 <210> SEQ ID NO 1056 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1056 taaaatagca agtaaatatt ttgactgtaa rgctaatagt tttgcatttt aattgcgttt 60 t 61 <210> SEQ ID NO 1057 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1057 aaatgaggat acaagacaaa gacgatacat wccgagcaaa taaggtgttg tatcatttta 60 t 61 <210> SEQ ID NO 1058 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1058 aatggaattc attctgaaaa tatacctgaa raagtctgtt tctaattatg gaattagtaa 60 a 61 <210> SEQ ID NO 1059 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1059 ctgctttagg cacagagtag agtatgcttt sgttgactaa actgagcaaa agcaagaaca 60 t 61 <210> SEQ ID NO 1060 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1060 aacatgtact gtgtaactgg aagttggctt sttttgatgg catttggata actataatta 60 c 61 <210> SEQ ID NO 1061 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1061 cagaaggcaa aactctctta gtcctttttt ygctgctata atagcaaacc acagactggt 60 t 61 <210> SEQ ID NO 1062 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1062 cagaatgaag tagggtatgc ctcacttact rgagtaaaaa cttatataca aaattgtaaa 60 a 61 <210> SEQ ID NO 1063 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1063 aggttgtatt tttatataag tctacacact wcactaaatt ctgaattcta ggcagagtac 60 c 61 <210> SEQ ID NO 1064 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1064 tgtcatacct aattcagaat atcgaagttt kcagacaaag aatttctatt ctattttaag 60 c 61 <210> SEQ ID NO 1065 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1065 taaaataaaa atggaaagta gtcaatggat rtggtttgat ttctgataat ttgaaataat 60 a 61 <210> SEQ ID NO 1066 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1066 ctactttcaa gaaggttctt gataatgcaa rttgtaatgg atttaacttg aaattcaaag 60 t 61 <210> SEQ ID NO 1067 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1067 ctgaagaaac atagatatga atgttaagcc yccattattt tctagtactc tctcagatat 60 a 61 <210> SEQ ID NO 1068 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1068 tggttaatat taactgtata cgatgtagtc yttatctgca ttgatttctg gtgaatcaag 60 a 61 <210> SEQ ID NO 1069 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1069 gaaagaagta actcaactag aatgggttag rttagaagta taaattagtt gacagagcat 60 t 61 <210> SEQ ID NO 1070 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1070 atgcctgaag agtaaaagag gtctattttc rtaactagaa gacgaaactg aaggttattt 60 t 61 <210> SEQ ID NO 1071 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1071 gcacaaggaa gatatgtata agaaggaaac rtagcaaagg caaaatattc tagttcactt 60 c 61 <210> SEQ ID NO 1072 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1072 ggaaccgata tgtgctttca gagttagctc rgtagggcaa tttcattttc tcttgatgtt 60 g 61 <210> SEQ ID NO 1073 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1073 agacataatt ggtttagtgg aaacatggtt rgtccgaatg ttaatcttcc ctcttaatat 60 g 61 <210> SEQ ID NO 1074 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1074 taggtttggt attccaaatg tagaaacgaa sgctcagaag agttacttgt cagaaagcaa 60 g 61 <210> SEQ ID NO 1075 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1075 aaatttaatt tccttttaga atttcagcaa rtaaacatta ctccatcaaa atttattttg 60 a 61 <210> SEQ ID NO 1076 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1076 tcctgaatat tggaagacca cagaaaatgc raagaaacca ggctcacatt tattttagtg 60 a 61 <210> SEQ ID NO 1077 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1077 tcaggaatga actggcttgt tactggttac ytgcacctgg tggaaaagta cactcaaggc 60 c 61 <210> SEQ ID NO 1078 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1078 cagtggagac ctgtaaccat tttcctgtaa yttggtacct gttagtctat cagctcagtg 60 a 61 <210> SEQ ID NO 1079 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1079 agtcacataa atttgtatgt accattcaat yctcaagaca acctgtaaat acaactatta 60 t 61 <210> SEQ ID NO 1080 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1080 atctatttat agaagttgtc acttaagctc ytaattttat caccaaattt caaatccaag 60 t 61 <210> SEQ ID NO 1081 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1081 agtaatgtct tacaaactgc atctgtttat stttaaattc caaatagaat gtcatccaaa 60 t 61 <210> SEQ ID NO 1082 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1082 gcaaaataaa ggtaagaaca atccacaaat kttcaactgt tcatatattt taaaagcttc 60 c 61 <210> SEQ ID NO 1083 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1083 ggtgtatctc ttgcattagc tgctgaggaa rcaagggagt actttgagac atgataatac 60 c 61 <210> SEQ ID NO 1084 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1084 ctcagcccac tgcaaaacat caggtctccc ytcttcatca gacttttatt tcattttgct 60 t 61 <210> SEQ ID NO 1085 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1085 cagacatgct aggtcttgaa gtaagaaaat yctagtgacc caaggaatcc tctggcattt 60 g 61 <210> SEQ ID NO 1086 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1086 ttttgaggac ttagtcataa attatttcct raggcccatg tctagaatgg tgtttctgag 60 g 61 <210> SEQ ID NO 1087 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1087 gttctggcag tttctgaact cttaatgata ytttgatgac atccagttag atgctgaata 60 c 61 <210> SEQ ID NO 1088 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1088 acatctgaga gactgtcatg aggggcctca ytcagagaaa attaccttaa agcaacatca 60 a 61 <210> SEQ ID NO 1089 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1089 aacaagaatg ctcagaaata gaatgctatg rctttttttt tttcctttct gattaggatt 60 c 61 <210> SEQ ID NO 1090 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1090 atatatgagt ctatttttct gctttaatgg rtacaatagg gaacacataa gtgagtcatt 60 c 61 <210> SEQ ID NO 1091 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1091 tagttgagtt aaaatgggga tacattttag ktgatcaaga atatgaattt ttactactaa 60 t 61 <210> SEQ ID NO 1092 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1092 cagagaaaac tcagctctct ataaattttc sccttaaggc ctcagcaacc ttccattcac 60 c 61 <210> SEQ ID NO 1093 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1093 aatgatttgt ttcactgtgt cttgccactc stttgataag cagtctctct caagaattgg 60 g 61 <210> SEQ ID NO 1094 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1094 tccatcttcg catgcctcta ttacgcctat stgaatgtgt tacaaatagt aggtaaccag 60 a 61 <210> SEQ ID NO 1095 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1095 cctaaaatca gactcaccgt tatctctatg ygcagaagct gtgcagttct caccaagtta 60 a 61 <210> SEQ ID NO 1096 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1096 aataccagtt ggactgagag ccttttcaat ygtaggtaag agacagtcac agagactccc 60 a 61 <210> SEQ ID NO 1097 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1097 actaataaca actgtaattt caaagtatga ygaatgaatg tcatcagcat tttggaacat 60 c 61 <210> SEQ ID NO 1098 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1098 caatactctg cagactcgaa aaaacatyac rtacattctt ggaacttccc agtggtttaa 60 t 61 <210> SEQ ID NO 1099 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1099 gtcgattggt acatttgtgc aaagacagat wtgacttcca aacaagacag acattcatta 60 t 61 <210> SEQ ID NO 1100 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1100 aagagcaggg atttccatga cctggggtct rtggatcagc ttctaaatac ccaaacctct 60 g 61 <210> SEQ ID NO 1101 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1101 gagcagggtg ggtgtgccct cctaagctct sgaatagcaa atgccaaact cacatgtctg 60 t 61 <210> SEQ ID NO 1102 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1102 cagaaatata ggtggtctgg aaagcaacct ygggagtttg tagttatgtc actactggca 60 g 61 <210> SEQ ID NO 1103 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1103 cagagtgata ctccatttag tctgtgaaaa wgtaatcaaa aggtcactca cctaagtggt 60 a 61 <210> SEQ ID NO 1104 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1104 ggagagtaga gtatggttta aactacagaa ygaagtgtac agattttaga ttctggcatg 60 t 61 <210> SEQ ID NO 1105 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1105 tagacatcca ataagatgct tactgagtaa yagaccccat tccataaggt tcaagtgaat 60 t 61 <210> SEQ ID NO 1106 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1106 aacaccaggt taccatccca gtttgtctta yaagattaac acaaaagaga accctatata 60 c 61 <210> SEQ ID NO 1107 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1107 ttcatgtcca agtgtattca gggtttagct ycaaattgta agtaagaaca tgcaatattt 60 c 61 <210> SEQ ID NO 1108 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1108 ttatttttca aaaaatagag tgaaaaccaa yagtgaccta aatacagtgt gaatgcaaaa 60 a 61 <210> SEQ ID NO 1109 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1109 ataatgaatg cagtctcgcc attcaaatgc raccataagt acacagaaga taagaattta 60 a 61 <210> SEQ ID NO 1110 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1110 agagctttac caatgtgcct ggagcataat kaaagaggaa aaatcacatg taggggcaag 60 t 61 <210> SEQ ID NO 1111 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1111 gacacgctgc agggaaggtc ccacattctg racctactgg aggttatagt cttacttctg 60 t 61 <210> SEQ ID NO 1112 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1112 tattcgctta aagaatacca gttaccatcc rtatgctttc ggtactaaat ctccatttat 60 c 61 <210> SEQ ID NO 1113 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1113 aagaatattt catttgtacg gtggtcagta ytctctagtt taatgattta catttgaaag 60 t 61 <210> SEQ ID NO 1114 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1114 aaaaataatt tgtttttacg aacaatgaac yctctggctt attacacata ctttaaatac 60 t 61 <210> SEQ ID NO 1115 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1115 gtatcaggca ggagagttgc aaagcctctg yggatcaagt cttcagcttc agcaaaagcc 60 c 61 <210> SEQ ID NO 1116 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1116 aggtgagtgc tgtgataaag aactaaaagc yattgcctgg tacttaggaa gcacactaat 60 g 61 <210> SEQ ID NO 1117 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1117 aaaaggtaca aggtgatgtt tacacacaca ytgaggagag ggttttatta caaagtttac 60 a 61 <210> SEQ ID NO 1118 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1118 ccaaatagct tgttggcaag tacaagtata rtctagcatt tttataactg ggtactaaaa 60 a 61 <210> SEQ ID NO 1119 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1119 caactaccaa cttactgtga taagtcttac matagagcct tatcctagga actagagatg 60 a 61 <210> SEQ ID NO 1120 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1120 tttaaatagt gcctcccaca tataatgttt mccgaaagtg tatcttaata tctcctgaat 60 a 61 <210> SEQ ID NO 1121 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1121 aggtggtgat gggccaggtt tctgagatat rtttccaaga ggcttggcat gcatttgcac 60 t 61 <210> SEQ ID NO 1122 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1122 tactctctcc tggggtagtt tcaagtccca ytggctttaa atattgtcaa taaatcaaat 60 g 61 <210> SEQ ID NO 1123 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1123 aggtaccctc tttaccaatt gacagagatg raaacctgga ctccctactt ggccttctat 60 g 61 <210> SEQ ID NO 1124 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1124 gtatggatta atgaacatgt cttatgctta kgaagtggaa ctcattattc ttgattaaag 60 a 61 <210> SEQ ID NO 1125 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1125 catctttccc cctttccagg tcacccaaag stcagctctt aaagatacac tgttcctcaa 60 c 61 <210> SEQ ID NO 1126 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1126 tctatactaa atcctgattc tgtcccttgt ytgaactcac agtgtaccca tgtaattcta 60 c 61 <210> SEQ ID NO 1127 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1127 ctttctgttg ccctccaatt ctactactct mcgctgactc tgtcatttat atcctgattg 60 g 61 <210> SEQ ID NO 1128 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1128 ttggcctgat tttgtttttg tctgtaaact yctgaagggt agaatttata ctcttttcat 60 c 61 <210> SEQ ID NO 1129 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1129 ctgaaagatg ctcctcttcc tcagaaaaag waaccctcgg acacaccagg tgtgggtcag 60 g 61 <210> SEQ ID NO 1130 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1130 atccaaaagt atcacatttt ctaaaaatac raacaaagct ttaatataat agataattac 60 t 61 <210> SEQ ID NO 1131 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1131 tcattggtca gtgatgggac aaaggctcgg yggtttttga gctcccctgg tgattctaat 60 g 61 <210> SEQ ID NO 1132 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1132 ttcaccttgg ttctctgaca cccatggaaa rtttaggtta gggagagaga gtggaaagag 60 a 61 <210> SEQ ID NO 1133 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1133 cactatcacg agaacaaaat aagggtaaac rcctccatga ttaaattacc tcccactggg 60 t 61 <210> SEQ ID NO 1134 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1134 gaaactgcac ttaatttgct tgatggcata ratgtttcag tgcctagatg gtgtcagtca 60 c 61 <210> SEQ ID NO 1135 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1135 aggacattgc tgtaattttg tccccctcat rtccagcgag ttgtctgagg ctctccgtgt 60 t 61 <210> SEQ ID NO 1136 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1136 tccctaaaga actatccaat tttctgcctg ygctagtctt tgtgatgttt atgatgattt 60 a 61 <210> SEQ ID NO 1137 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1137 gccaagttgg gaccacgggc cgggctagaa ygatccatgg aaaagttctg tgctcagggg 60 a 61 <210> SEQ ID NO 1138 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1138 actcacctaa ggtcacagaa agaatggtac mgaggcaggg ttgagccaca ctgcctaatt 60 c 61 <210> SEQ ID NO 1139 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1139 aacagacatg gctgtcagca gttttggaga ygcaggtaat tagtcctgct ccagctcctg 60 c 61 <210> SEQ ID NO 1140 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1140 taaatagagg ctatgctttc ctctttgtat rtcccaaaac gccttcctca gcacaatagc 60 t 61 <210> SEQ ID NO 1141 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1141 ctcctggaca aggcagatgt ggtagtcttt rgatttagct atagtagttg tgactgaggt 60 c 61 <210> SEQ ID NO 1142 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1142 gcaaataaat atttcaagca ttcctataca rtttaaccac atcaatcaac tatagaataa 60 a 61 <210> SEQ ID NO 1143 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1143 cctgtgtgta gaaggcatag gtcattacac rctcctgatg ttgcctgcaa aggctatatt 60 t 61 <210> SEQ ID NO 1144 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1144 tgatggacta gttagaattt caccccgggt rtataagcct gaacccattg gtccatttct 60 a 61 <210> SEQ ID NO 1145 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1145 ttcctctctc caacatagtg ccagactctc rtattaggaa atgatgaaac catcaaccaa 60 a 61 <210> SEQ ID NO 1146 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1146 taaattgagt cactttcttg tcaaagagga sagtggttct tcagctctgg ggtcaatttt 60 a 61 <210> SEQ ID NO 1147 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1147 gttgtcatga caattaaatg acatcatgtg ygtgcaacca aaatagcatt tggctcatcc 60 t 61 <210> SEQ ID NO 1148 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1148 tcatcagaac tgccgcatcc tctctggccc rctttctgtc tggcatttgc ctgacatatt 60 c 61 <210> SEQ ID NO 1149 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1149 ctgccaagac ggaggagagg aggcagtgtc rtttttattt gtcacggtac tttctgtgca 60 c 61 <210> SEQ ID NO 1150 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1150 tgggtcatgg tcagaaaatg ttaaaagtca ytggatgaga gtatttctga ggtccctgag 60 a 61 <210> SEQ ID NO 1151 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1151 gaggaacaga tagagaggga caatacagcc yggtacagga gatgaagggc cccggggcca 60 t 61 <210> SEQ ID NO 1152 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1152 agctaaaaaa aaataaaagc ttagacacat rattttgagt aaagaaaaca aaaaaagcca 60 g 61 <210> SEQ ID NO 1153 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1153 gactattcat atgtctatgt cttcagtgtt mtgtgagaga aaataaactt tatataattt 60 g 61 <210> SEQ ID NO 1154 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1154 gggaccaact gaacataacc tgcttaaaag wtccacctaa attattggaa tccttttata 60 t 61 <210> SEQ ID NO 1155 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1155 atgaggcaca catccttttg tgaactatag yccatgatac tacaatgaac aaagtacttg 60 g 61 <210> SEQ ID NO 1156 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1156 actaatctat ataaaaatgc agcattctga wccgcatgaa accatttaca aaattattga 60 a 61 <210> SEQ ID NO 1157 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1157 ttgttctgtc aagctcattt ctagggctca rttgccagtc atttatggcc agcgaaataa 60 a 61 <210> SEQ ID NO 1158 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1158 cctacccaag tgccatgggg ctcagtctct wcggagggac attttctttg tttttggttt 60 t 61 <210> SEQ ID NO 1159 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1159 atggaagtca atttctgagc ctctaagact sgcaagttgg gtataaacaa aggaatggct 60 g 61 <210> SEQ ID NO 1160 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1160 gtgtcctggt ttagacagta aatggttatt stgcttaatg caagccaagt taaagaacta 60 t 61 <210> SEQ ID NO 1161 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1161 accaaaccac agtcaatatc aatggcagaa yagcaggcat taactggaac tgacccaggc 60 a 61 <210> SEQ ID NO 1162 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1162 ctttggttat ccaatcaatc actttcattt sttggctttt gggcaaactt ttttaaaaaa 60 t 61 <210> SEQ ID NO 1163 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1163 atggtaaagg ctctggcttt gactctgaga yaagtcaaca aattgagaaa agactaaagc 60 a 61 <210> SEQ ID NO 1164 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1164 gcaagatagg atgtgggctg cagaaacaat yggggagaca tgagcctggt taaatattca 60 g 61 <210> SEQ ID NO 1165 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1165 aggcaacctg catgtatgaa agaactcaga yacaatggcc agtttcacaa aaggaaacaa 60 g 61 <210> SEQ ID NO 1166 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1166 aaaaactgtc tttcccaact gcatactaga rtattataga tttggaatat tttcttcttt 60 g 61 <210> SEQ ID NO 1167 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1167 tacccagaag aaatgccaag gttggaagta csagctatat agggtgtgtc aaaagagtcc 60 a 61 <210> SEQ ID NO 1168 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1168 tcagcctttc tcttacagct aaaagtgatc rtggcacgac acaggggcaa tgagctctaa 60 c 61 <210> SEQ ID NO 1169 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1169 tctcttagct caggcgtgaa gaaattcaga scacaggtag attaattaac tccaggaagg 60 a 61 <210> SEQ ID NO 1170 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1170 agagaaaaac accaggtagc cccctccagg yctcctgatg ctcagacctt gctcaagaag 60 g 61 <210> SEQ ID NO 1171 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1171 ctgaacaatc ccacgaagta gcatatttca yaatgaggac acagaagctc agaaaggctg 60 g 61 <210> SEQ ID NO 1172 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1172 agatgccaca agcaagactt caacccccta ygtggcaagt ccctgcccgt ctctcctctc 60 t 61 <210> SEQ ID NO 1173 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1173 aaaatgtctg cttctgcact tcccaaggac scttctaagc atcactcata attcaatatg 60 a 61 <210> SEQ ID NO 1174 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1174 atttgtgaat ggctcttgca aaccttaaca ygcaaagcta atgacagatt gtatcagagg 60 c 61 <210> SEQ ID NO 1175 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1175 tcctcagtcc tagaaatgcc acgtgaactt ygaacatgga aagtttttta tttttgagag 60 a 61 <210> SEQ ID NO 1176 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1176 cagtttaaac aaaaactgcc caatgtctcc macaggcaat tgtgtagcaa caacagtcac 60 a 61 <210> SEQ ID NO 1177 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1177 gtagtgtggt attaaaatct aggacttcgg ratgcaatag cagtgctcag tttatttgtt 60 t 61 <210> SEQ ID NO 1178 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1178 acatattttg atccgattct agagctagca stcgctgtgt tgaaagtgat ggcggtgatg 60 t 61 <210> SEQ ID NO 1179 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1179 gtttatacaa tatcctctga aagcaactta saaggacaga aagcctgaaa caacaccatg 60 a 61 <210> SEQ ID NO 1180 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1180 aaaagcatat gaataccatt tatgataaac macaaagtct ctggatgggt aaatgcctca 60 t 61 <210> SEQ ID NO 1181 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1181 ggatgcctcc caataaagga actttcctca sagatcttgt agagttggtg aagagaatcg 60 a 61 <210> SEQ ID NO 1182 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1182 aagaattaga taatctatga aagatgtgac wagcctcatc gtgctcacta accatccatc 60 t 61 <210> SEQ ID NO 1183 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1183 gggtatataa ttactgctca gtgaaagtga ytatgcatac ctgtatcatc taaaggaatt 60 t 61 <210> SEQ ID NO 1184 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1184 gaagatgaga tattagaatt cccagtatag ktgtgtgtat attcatatgt ttgtatgtat 60 a 61 <210> SEQ ID NO 1185 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1185 aataaaagaa gaaaaaaaaa gatggcttag rttttaccca aagataaacc actttaggag 60 g 61 <210> SEQ ID NO 1186 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1186 gcagaagatc accttagaga aaatccgaac ygactctcct atcttagaag tcatccaggc 60 t 61 <210> SEQ ID NO 1187 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1187 aggccatgtt ccagcctctc catgccacca yttggttccc tttctgccca cctcctgtgg 60 g 61 <210> SEQ ID NO 1188 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1188 gtgacctgcc agaacatgtg ctaagtattt yccgtgcatt tcctcagtta attctaacaa 60 c 61 <210> SEQ ID NO 1189 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1189 aagaaggcct gaacctgcac acagcctgcc rctggggtat actagacaca gaggaggacc 60 g 61 <210> SEQ ID NO 1190 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1190 gggccctctg caaaattctc aagtgaggcc yaacaaatca caggccctgc atgtacacaa 60 a 61 <210> SEQ ID NO 1191 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1191 aaaaccagag aactaagccc cactccaggc kgaagaagtg cagccccagc ttactatcag 60 a 61 <210> SEQ ID NO 1192 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1192 ccatacctga aacaaagcct tgcgctttaa rtaacagggg agcttccctc tcctctagga 60 g 61 <210> SEQ ID NO 1193 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1193 ttcttgatca ccatcacaga aaaactttct ytgaccatgt ctgtatcaaa tattgcatca 60 t 61 <210> SEQ ID NO 1194 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1194 atgaagtcaa agcccctcct cctcttgtcc rtagatagag tagaccaact cacagaactt 60 c 61 <210> SEQ ID NO 1195 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1195 ggcaggtcat gagtgattcc tgaatgataa ragattccat aggatttcag agaagagtca 60 c 61 <210> SEQ ID NO 1196 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1196 tgtctgtttt ctggcaatgg ccatcctagt rgacataaag tgatagctca atgtggtttt 60 g 61 <210> SEQ ID NO 1197 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1197 aaagagtgta gccttgggga cgtggaagcc yagagcattt ggaagacgca aacaagggag 60 a 61 <210> SEQ ID NO 1198 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1198 taaaaaactc tctatcgtat acatctttac mcacgctgca gcgccaagac tccaatggaa 60 t 61 <210> SEQ ID NO 1199 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1199 ttaaggtaga ttaagccatc gattgtatca wagagaaagt gtgaaaaact acttttagaa 60 a 61 <210> SEQ ID NO 1200 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1200 tgtctccaag aaattccaac gaacatgcac yctttagctg ctcttcctcc aacacacccc 60 a 61 <210> SEQ ID NO 1201 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1201 gagatggctc caaaatgaga ttctacaact kagccactta caaaaagcta tcctgttgat 60 a 61 <210> SEQ ID NO 1202 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1202 caaaataagt atgctctatt tgttccttca matctctcca ggcctccagg cttaggaaag 60 c 61 <210> SEQ ID NO 1203 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1203 acaagcaact atcagcatat gcaagctatt rtttgttttg caccctattt gagaaacttt 60 c 61 <210> SEQ ID NO 1204 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1204 ggaagtcgct ggggagcccc aatgttagat mttattttca catcatcctt tctcctctcc 60 a 61 <210> SEQ ID NO 1205 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1205 tgtttctaga tgctgtatct agaacttttt ygggttgact ctgttttgca caccataact 60 a 61 <210> SEQ ID NO 1206 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1206 ccctggaaat gagtaaatct gaaccacagg mcatgacaat cattcaaggt gctgtgctgg 60 a 61 <210> SEQ ID NO 1207 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1207 gcatgaagat agtggactgt gacacttgtt ragcagggaa gaattggtct gaagaatgct 60 t 61 <210> SEQ ID NO 1208 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1208 tgtctgactt gggcattaat gagatgaaga ygagactgta ggtcagatga tgactgtttt 60 t 61 <210> SEQ ID NO 1209 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1209 ctgcagtatt ttggcctttc aggaaaagat stgctcaaag accaattgaa cattcttttc 60 t 61 <210> SEQ ID NO 1210 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1210 agaagaaatt cagcaaaatg tatcagaagc stttaacatc tcctgttaaa gaaagagcag 60 a 61 <210> SEQ ID NO 1211 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1211 tccgtagcaa ggctatagga acattgcatc raaaagtaca gcttctgggg ggtctctgtt 60 g 61 <210> SEQ ID NO 1212 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1212 agaatttttt ccaatcttat tttctcctga rtaaaaggtt cctccaaatg agcccaacaa 60 t 61 <210> SEQ ID NO 1213 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1213 taactcacat tgagaacttg tgatctgaaa rcactaagga atttctgcca ttgcaggtag 60 g 61 <210> SEQ ID NO 1214 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1214 agcccctagt cacccttctg aacaccataa rgtaagttgc gatctccatc agacactggg 60 g 61 <210> SEQ ID NO 1215 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1215 gccaggatcc aagaaaaaat ggaaagtaga ycaatgtaag cgttaaaaga acacatttta 60 t 61 <210> SEQ ID NO 1216 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1216 catttttctc tgttatgacc gtgttttttt kgtcatatat aagaaatctg tattcaggtc 60 t 61 <210> SEQ ID NO 1217 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1217 tctgataata aagatgattt tacttcttct yttccattgt ggataactta ttttttttct 60 t 61 <210> SEQ ID NO 1218 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1218 tggggaattg aataatagaa attttgaaga wggataggat cttggtgatc aattaatgta 60 c 61 <210> SEQ ID NO 1219 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1219 tggtttagat tttgtgatga ttctaaaata ytgacagtga attaatttgt tacttcaaaa 60 t 61 <210> SEQ ID NO 1220 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1220 ggcagatggt tcttcctttc tgtcaagagc ygtgtcttct gttttcccat caccgttgat 60 a 61 <210> SEQ ID NO 1221 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1221 cctttgatgg ttattaaaaa cagatgttca rtgttcttgg taaatcttaa aaattatgcc 60 t 61 <210> SEQ ID NO 1222 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1222 tgtatctctt ctctgtggct gctaaaagct ragaaagcct ccatctgtta ctaattcttg 60 t 61 <210> SEQ ID NO 1223 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1223 gcaatagtac caaggaccac agaagaagtg wtgttttgag aactatgcct agacctcaat 60 g 61 <210> SEQ ID NO 1224 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1224 atattcatca agtcagaggc ttcttagact ygctgccctt gactcactat gttgctctca 60 t 61 <210> SEQ ID NO 1225 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1225 tgcccttaaa ttaaaaacac cacctcaaac rgcaattaaa tgcgcataca catgtgtaat 60 g 61 <210> SEQ ID NO 1226 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1226 tgtcaccagc tatcatgctg ctcctgttaa ytgattcatt aatccagtac acccacatct 60 g 61 <210> SEQ ID NO 1227 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1227 cttattcata cacagactca cataaggcaa rtatcaactt tgttcctttc atgtttatta 60 a 61 <210> SEQ ID NO 1228 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1228 tgggaccacc atcatctatg tggttcatca wggactgaag ctctgttatg caccacatga 60 c 61 <210> SEQ ID NO 1229 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1229 caggaccatg aaggatttca agtaggtaca ygacaatcac atgggtattt tacaaagatc 60 a 61 <210> SEQ ID NO 1230 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1230 atgctagagg atggtgttat gaatagataa ytttgtcatt aaatgacgtc cactgctatg 60 a 61 <210> SEQ ID NO 1231 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1231 tttttcagtg cctgccattt tttattagtg rctccttaac aatctggcag gatatatagc 60 c 61 <210> SEQ ID NO 1232 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1232 tcctccttct cagctctctc cagtgtttgc rtctatcctt cagagccagc cccggctatg 60 t 61 <210> SEQ ID NO 1233 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1233 ccaggggttt ggagatgaaa cggacaaaaa mtttactcag ctgtcaaggc aggaacatat 60 t 61 <210> SEQ ID NO 1234 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1234 taaccaaaag gcattctaat tttcatgcta ygttgagtat aaatataaat tcaaggcagc 60 c 61 <210> SEQ ID NO 1235 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1235 agatccctca aatttttgtg aaatgattat mggtacaagt aagtggacaa gtattttaga 60 t 61 <210> SEQ ID NO 1236 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1236 ttagcatgtg tctaataaga atcaatcttt kcagttaaac aggcaaatgg gctaatgttc 60 t 61 <210> SEQ ID NO 1237 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1237 tcttcaaagc cagcttcata tcccatggta ytttctcact aacctcttac tcctaaccca 60 c 61 <210> SEQ ID NO 1238 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1238 ctaatgtact gaattcgccc atatgccccc mggcaagaag agagaaaaaa agttatttct 60 g 61 <210> SEQ ID NO 1239 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1239 ctctggaaac tttaagacct aggagcttat sagaaatgcg gaatctctgg ctgtgtcaag 60 a 61 <210> SEQ ID NO 1240 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1240 aagttcaaaa cttcatcaat cttagaacct waccaaactg aattggttta tcgtaactca 60 c 61 <210> SEQ ID NO 1241 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1241 ggaaggaaga aaaagagaag aaaataacaa rctactctgg ctccataaac atgacttgcg 60 a 61 <210> SEQ ID NO 1242 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1242 tgtaagcacc ttgagagtaa gttatgagtc yttcatgtgt cccctgcacc gaacacaggt 60 t 61 <210> SEQ ID NO 1243 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1243 taggatcttt gcatgttcga gagggctctg ytgtgttcca ctgtagctgg ggattttgat 60 c 61 <210> SEQ ID NO 1244 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1244 tgattttatt ctcatagtca catttttgtg yttgttggaa tcataatgaa agcatacgca 60 t 61 <210> SEQ ID NO 1245 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1245 ctgctggcat tcactttctc tgtttagtaa rttcacccct ctggcatgtc ttccctagaa 60 t 61 <210> SEQ ID NO 1246 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1246 acctggccac cccaccctaa tcttttatta ygcagaaggt ttctacgtgg ccagcgcagc 60 c 61 <210> SEQ ID NO 1247 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1247 aagctcatga ttcttcagtt gacaggcgct wttcgtatgt taatccactg tgcaaatggc 60 c 61 <210> SEQ ID NO 1248 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE48 gccatattcc atagtccatg acaatctttc ncccctgcca gctgcccaag cgggtccaca 60 t 61 <210> SEQ ID NO 1249 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1249 ggggtttaag caggttagta caccgattct ytttctgaca gaagctggga caagagaata 60 g 61 <210> SEQ ID NO 1250 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1250 atttaataac ttagtaaagt tcaaaattgt sagttactta ttaaacataa acatgtgaca 60 a 61 <210> SEQ ID NO 1251 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1251 attaaaccag tctgcatcag ctacagtgta mgtctcagaa acagatctga aaccccagct 60 g 61 <210> SEQ ID NO 1252 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1252 atgaaccctt ttccagggcc tggatagggc yattccctag gtccatgtgg gctgggagtt 60 c 61 <210> SEQ ID NO 1253 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1253 tatatgacat tgacttgggg atgaactctc mtttcccatg ctagcaaaca tcttggctgc 60 a 61 <210> SEQ ID NO 1254 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1254 gtcattgtaa aataccatct gcctgtcaag yattgtttta aaacattaaa tttgctaaat 60 a 61 <210> SEQ ID NO 1255 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1255 tgtgggatta ccagtccggg tatcagctct ytgttaatct tccagttctt gcatttctta 60 t 61 <210> SEQ ID NO 1256 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1256 attggcagac ttaattgctg ctattccaca sgctaaataa gagctggaaa ttaattttcg 60 c 61 <210> SEQ ID NO 1257 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1257 ttaatcataa aactttcatt ttccagatca magctaagaa aagattgcag agcaccaaat 60 a 61 <210> SEQ ID NO 1258 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1258 aagcaaagta cacctaactc tggctatccg yttcaatggc tcacaagaac ctgggcctcc 60 a 61 <210> SEQ ID NO 1259 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1259 tggtacttgc tgtcttttgt gatttactga ytttgctcca gggaaagctc taaaccatta 60 a 61 <210> SEQ ID NO 1260 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1260 ttgtaaattg atgagagcag tcctgcctgg rtggggcaag acagaaaggc tggaagttta 60 g 61 <210> SEQ ID NO 1261 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1261 ttctcatagt tctccactga aactctgtcc ytatcaaaca ataactctcg actcccccac 60 a 61 <210> SEQ ID NO 1262 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1262 gtgatccttt ttcatttttt cttagactgc yagtacatgt ttaacccatt tcttaagtta 60 t 61 <210> SEQ ID NO 1263 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1263 gtcattgctc tgccatcatt ggcttcttcc rtgtttactt tgtgccaggc catactgagc 60 c 61 <210> SEQ ID NO 1264 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1264 tgactaggag cttgctttgt acaggcaccg ygctaagttc ttacatgccc actgtaaggt 60 a 61 <210> SEQ ID NO 1265 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1265 gtaggggctg tcgggggaat tacacgtgcc rtagaagtac atagaaggag catccagctt 60 t 61 <210> SEQ ID NO 1266 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1266 gagactgtgg tgctgtcctg caggcacatc rtggaagaac ttatcagacc catgactaca 60 a 61 <210> SEQ ID NO 1267 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1267 acctctttaa atattttaca gaattcgatt mttttcattg acaccatcag cctctattgt 60 c 61 <210> SEQ ID NO 1268 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1268 aagtatcaac atcttgtaac accctcttta ygagttaaca acaagcgttt tagtgcatta 60 a 61 <210> SEQ ID NO 1269 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1269 agtggctgga tgacaaagga ggaatcagca rgtgtttttc tctgtcccct gtgtgcaggg 60 t 61 <210> SEQ ID NO 1270 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1270 ccccctccct tctgaaacca tattttacat stctggtcct cattaaattt tctgtaactt 60 c 61 <210> SEQ ID NO 1271 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1271 aaatctagaa agctttgaca gtgggaatgc rtagtgaatg gctctaagtt ctccctccat 60 c 61 <210> SEQ ID NO 1272 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1272 cattaaagaa agggaggcat aaagagatct ygcccgatgt caacctagtg agtcactgat 60 g 61 <210> SEQ ID NO 1273 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1273 aacagtttat tattagacat gtaaaaacac ytttgtcact ctgactggta aagaatggca 60 t 61 <210> SEQ ID NO 1274 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1274 tccccttaga aatccaaaaa ggattgcatc raagttctgc tatgtgagca gcatttttca 60 g 61 <210> SEQ ID NO 1275 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1275 agcaccgtgg gtgccttcag aattctgaaa rggccctgga tggtatcggg tagagccgct 60 g 61 <210> SEQ ID NO 1276 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1276 ctgtttctac actgtctgga agaagaatgg rcattgttac ctcaatatgg gaccaccagg 60 g 61 <210> SEQ ID NO 1277 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1277 gagtggttat gccaggcctg gttttctacc kccacctgcc tcacgggatt aatcatgtgc 60 c 61 <210> SEQ ID NO 1278 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1278 aaacggggat gcatctagga gtgcctgccc mgctgcctca gttctctgga gtgtaaggtt 60 a 61 <210> SEQ ID NO 1279 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1279 tatcagcaag acagtcaatg agatttagga rgaaggagaa tttatacctg ggggcggggc 60 a 61 <210> SEQ ID NO 1280 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1280 tcttttaacg ggagatttag gagagactca yagaaagagg atcaaaggtc aggagactgg 60 g 61 <210> SEQ ID NO 1281 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1281 accaaggacg tagtctcacc cagacagata sggtccctgc agctcttccc agctctcctc 60 a 61 <210> SEQ ID NO 1282 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1282 aggtctgggc tgcttcaatt tgtcttctgt ygtcagggct ccctgtgagg cctggcgaga 60 c 61 <210> SEQ ID NO 1283 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1283 ccagtcgcag tgaagactgc gcacaggagc rtgttcatag gagcatggag aaaggcccag 60 t 61 <210> SEQ ID NO 1284 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1284 cattcttgtg ggtaagttcc atgagggaag rtctttgttc agcttacagc tgtatctctg 60 t 61 <210> SEQ ID NO 1285 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1285 taatttgtct taactctttc atcttgcgta waatttccat tctgtcatcc acaaccggaa 60 t 61 <210> SEQ ID NO 1286 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1286 gggtaaataa tgaaagttct cttccacacc rtgttagcca ttttgagctt taatctggag 60 g 61 <210> SEQ ID NO 1287 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1287 ccacctgggt gtgcttaaaa agagacaaac rtggtaacga tcaaataccc tagataaaat 60 g 61 <210> SEQ ID NO 1288 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1288 tagttaatga catgaccata tttttatttt ygatgatcat tccggtgttt tagtgaattt 60 g 61 <210> SEQ ID NO 1289 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1289 ggtgccatta tttgaatgca tgaaacttct racctataag acatgaaata cattagccag 60 t 61 <210> SEQ ID NO 1290 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1290 atagtgggat cttgtttggg ttttcggaat ycactgtatg tctttgattg agcagtttaa 60 t 61 <210> SEQ ID NO 1291 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1291 tttacaagct gccaggtgat ttaaatccac rtagtctacc agccaaactt agagcaaaca 60 g 61 <210> SEQ ID NO 1292 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1292 cctaacgttc ctgtgtttga tagcatcctc yttctactta gggcctgtgt gttagtaatg 60 c 61 <210> SEQ ID NO 1293 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1293 ctattttgcc caggtgaagc tggaccgctt rtactcttct ttgagaggag cagggtatga 60 c 61 <210> SEQ ID NO 1294 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1294 ttgcaataga gatgaccagc agctagctac rataattggt acgtaaatat acacattgtg 60 t 61 <210> SEQ ID NO 1295 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1295 gaaaatctta atctcccatt tggccctttc maaagtataa gcacagatta cttttcctat 60 c 61 <210> SEQ ID NO 1296 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1296 tgaacatgtc atggctcagg aatcagcttc rttaccgtga tattctttca ttgatgggtt 60 t 61 <210> SEQ ID NO 1297 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1297 acaaaatgtt attgaaatat tcggtcttaa satagaaaac ctatcaacct ttagtgtctg 60 t 61 <210> SEQ ID NO 1298 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1298 tttcaaatga agcatgaagt tacatgcaat raactgaaat aaatttgatg ttgcctttgg 60 t 61 <210> SEQ ID NO 1299 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1299 tcaacatcct ttcacaatac ggctcttgac raggtaaaat ctagaggagt agtttatagc 60 t 61 <210> SEQ ID NO 1300 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1300 agatcaattt tttaaataag tacaaatctc yttcttaatc ggggtgacta ctggactaaa 60 g 61 <210> SEQ ID NO 1301 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1301 tgcttcttta tatgtaagag caggcattcc rtctacctaa attctgacaa gcccagtggg 60 c 61 <210> SEQ ID NO 1302 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1302 gtgtacactg gctgtgctgt ttctagcacc rtaaggcagt catcattatt gagccagggg 60 c 61 <210> SEQ ID NO 1303 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1303 aaaatgacat ttataatact aggtgctaat sagtaaggta aaatgtgata catctcaaga 60 g 61 <210> SEQ ID NO 1304 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1304 gaatggagtt tccattcttg ccctcaacat rcataagcga ctctttccca acatcatttt 60 c 61 <210> SEQ ID NO 1305 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1305 gcaacagatg acattatcaa aaatatgtct yttgaaaacc aagtcaagta cctagagatg 60 a 61 <210> SEQ ID NO 1306 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1306 agagagagtg tgtgtatgta tagtacagca rgagtaacaa cagggttgat attccacagt 60 t 61 <210> SEQ ID NO 1307 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1307 acttcctaag tgtttgagag gctgtcaagt rgggagtact ggaaaaatcc agggttctga 60 a 61 <210> SEQ ID NO 1308 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1308 cagcttctcg tagagttctg cacaagtcat yccgcagtag ggtgtgcctc ctggaagaca 60 a 61 <210> SEQ ID NO 1309 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1309 tgaaaaatgc gatagacaac aacaacagaa ytgatgcagc aaaagaattt gaattcaaat 60 a 61 <210> SEQ ID NO 1310 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1310 tacattctgg tacagccaca tgacagatta ytgagccatt aaaattatcc tcagggtgag 60 t 61 <210> SEQ ID NO 1311 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1311 ccagaaatat agcattttag tgcatttcac rtagtaacaa gagctaacag ctaatagatc 60 c 61 <210> SEQ ID NO 1312 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1312 gttggagata gaatcaggaa gaaataccag ktctcatact acatggtcat tcattccatt 60 a 61 <210> SEQ ID NO 1313 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1313 tcattattta cactaataat aatggcttgc rtttgaaata tgcttcagag ttaacacagc 60 a 61 <210> SEQ ID NO 1314 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1314 taagtaacac aggcacacca gatggattta yagtaaacag aagaaactta tgttagtctt 60 g 61 <210> SEQ ID NO 1315 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1315 ggagcagatg ttcaggtctg aatccagttt yttctagaca cctctttccg gatcaccccc 60 t 61 <210> SEQ ID NO 1316 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1316 catcttcccc ttgtccttct acggtggttt yctaacccaa cagagtggtc ctctgctcca 60 g 61 <210> SEQ ID NO 1317 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1317 cctgatctgg tccctgctac attctccaga kgcgttcttc agcttctgtc tccagccttc 60 t 61 <210> SEQ ID NO 1318 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1318 tcaattcaat acaacacatg gacaagaaca kcatacccaa gttgccttca taaggacttt 60 c 61 <210> SEQ ID NO 1319 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1319 aaaggaacca gtctagttat gaaacaaaca yaggtaacct tgactctagg actttttatt 60 t 61 <210> SEQ ID NO 1320 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1320 gccaacacac attaaaggtc actattctgc rttaacttga aaagagcaaa agcactgttt 60 a 61 <210> SEQ ID NO 1321 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1321 tagcctagag gaagggctca gacactgtgc rctaaactaa ctaaacacat gaaacacacc 60 a 61 <210> SEQ ID NO 1322 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1322 gtttggatgc tgtttgagta agacctacac ygagaattct cttaaatacc tagaatttgt 60 g 61 <210> SEQ ID NO 1323 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1323 aatcatttta cctgagcact gattctgggt rctggcaaaa gcagtccccg gagcagctcc 60 t 61 <210> SEQ ID NO 1324 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1324 aggtatcaga tgctcaatgt cttacactta yggaaccgtc aaagacagct gttaaatgtc 60 c 61 <210> SEQ ID NO 1325 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1325 tacttctgaa aactatttct ttaccgaaga rcatagagaa ataagggagt aatttatcaa 60 c 61 <210> SEQ ID NO 1326 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1326 atttgagaac ctttcagtcc ccaacaaaca yggatggttg gtcaccttgg ttttaagtcc 60 t 61 <210> SEQ ID NO 1327 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1327 ctgataaaca cctttatcat gaattgaaag kttaagagtt acagaagatg tctggttttt 60 t 61 <210> SEQ ID NO 1328 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1328 tctattccag tagcactcat ggaagatacc mctaagaagg agcaatggca ttgctgaggg 60 g 61 <210> SEQ ID NO 1329 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1329 atgaattcta gtgttaaatt tgcaaaagaa ygttcagttt tcctggcatt taggatttta 60 a 61 <210> SEQ ID NO 1330 <211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1330 tgtttaaaga tagttcaaar tcaaatgagc aatacaggaa ctctaaatga 50 <210> SEQ ID NO 1331 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1331 gtaggagaaa ctatagcata ctctgaatag rcaatagcct agatgggagg gacagaatgg 60 c 61 <210> SEQ ID NO 1332 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1332 cactttcccc actctagagc aatcctgctg ygtaaaatta gactgagaaa ttaaagccca 60 c 61 <210> SEQ ID NO 1333 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1333 tggaaagcat ttgctctcca ttaaacttac ygaaccttga caaaccagaa gggccaagaa 60 t 61 <210> SEQ ID NO 1334 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1334 gtgatgtggg aaagtggaag acccagacca rgaatcagaa gagctggatt ctagcaagtt 60 a 61 <210> SEQ ID NO 1335 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1335 caatagatgt tttacgttcc cttcgtaata wttaacgctt ggcctagatc cgagcattca 60 c 61 <210> SEQ ID NO 1336 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE36 ttcctcttag cacaacctaa atagaatttg nagcttctcc tatgacagac tctatgtgca 60 a 61 <210> SEQ ID NO 1337 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1337 ttaacatcat ggcatagcca aaaaacccca rtgtaatgca atactcttta tacttagata 60 t 61 <210> SEQ ID NO 1338 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1338 gcgggggtgg tctgtgctta tgtttgcatc raggtggagg gtagtgttag aggtatgggg 60 c 61 <210> SEQ ID NO 1339 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1339 gtcagccact tcaaagaaga agagaatagg rgagatccgc ttaaaagcac aaggttgagt 60 c 61 <210> SEQ ID NO 1340 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1340 tccctgacct cgtggcaaag tacaacacca rtaacggggc tcccaaggat ttcctcccca 60 g 61 <210> SEQ ID NO 1341 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1341 atgtgagttt ataaaatgga acaattaggg rgtgatgtaa gtgctgaaca aaagaaggaa 60 c 61 <210> SEQ ID NO 1342 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1342 aggattaaaa taaatgctac cagttacagg satgcattaa attaataact ttttccccct 60 t 61 <210> SEQ ID NO 1343 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1343 ccaactggac cagcactcca ctggctgata ytgcccatca cagcacacca agaggccatg 60 a 61 <210> SEQ ID NO 1344 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1344 aaatgagggg tttgtgtctg atactcctga ytaagtattt ttgagaatct atttgcatgc 60 t 61 <210> SEQ ID NO 1345 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1345 agaggagata gagctaaaga aaggaatctc rgtggaaacc cagacatccc cagaggagat 60 a 61 <210> SEQ ID NO 1346 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1346 tgtttttttc ccctagttac tattactcca yacttcaagg tcaaatgcca ataaagtagc 60 a 61 <210> SEQ ID NO 1347 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1347 tcctagggga aatacaaggt taagtatcta ygtgtctctg gtcacaatat ttttataaaa 60 g 61 <210> SEQ ID NO 1348 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1348 agttcattca aattcaaaat attataggaa raaaacttgt acttcaaagg ctattctttc 60 a 61 <210> SEQ ID NO 1349 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1349 catgaagctt ataatttata gccttggttc racatggaat tgtttaacat tgcctataac 60 t 61 <210> SEQ ID NO 1350 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1350 aaagcagata cttataatga caacatcctg matcaaagaa agattccctt aactcttttt 60 c 61 <210> SEQ ID NO 1351 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1351 ttctatgctt acccatctgt ttttttccca stttgctcgt ctctgtactt tgttccatag 60 g 61 <210> SEQ ID NO 1352 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1352 tgttaggtac cttcacttat ataagccctt waatcacacc agcctacgga ctgattattc 60 a 61 <210> SEQ ID NO 1353 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1353 aaaggaggtt taaatgaata ctttgttttg ycatgttcaa aaaaagagta ttaatatttt 60 g 61 <210> SEQ ID NO 1354 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1354 cagagacttt tctgatgatt tcaagtcctc rtaaacctag cagagaatgg accatgtgta 60 c 61 <210> SEQ ID NO 1355 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1355 cattcttgaa tatgaccttc tgaattggat wgcttttgta ttctagcaca ttttgttttg 60 t 61 <210> SEQ ID NO 1356 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1356 acaaggttcc caaaggccag tttgtgaatc rgaaccagtt ttcactagtg gtaaaatgag 60 a 61 <210> SEQ ID NO 1357 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1357 ttgtttatac atgggcatat ttatataaac rgggttacag gtctgtgtaa agaagttaca 60 t 61 <210> SEQ ID NO 1358 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1358 caccagctat tctaagtaag aactgaagaa mttttggatg gcatggaata tttcaaatat 60 t 61 <210> SEQ ID NO 1359 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1359 catatgatgg aagccctgcc ctctaggtac ygttagctta gttggagagg tgaaatctgg 60 t 61 <210> SEQ ID NO 1360 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1360 aagacatcca agacccaatg ctgcaagagg ragtgctggt tgcagccaca aaggctggca 60 c 61 <210> SEQ ID NO 1361 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1361 catcgcacat gaagcagacc caatgagtga stcagcaata aatcaacagt cttaatggag 60 a 61 <210> SEQ ID NO 1362 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1362 tttaataaga taatatgaga tgccatctaa rtaataatag gtacacttgt taagactttt 60 g 61 <210> SEQ ID NO 1363 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1363 tgattaggca ggttcagtag ggtgatattt staaagagct tggaacatgc caggtgcata 60 a 61 <210> SEQ ID NO 1364 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1364 ggtccgaagg tacttaagtg aacaagcaag yggatggagt ccatttgcca tgactcctgg 60 a 61 <210> SEQ ID NO 1365 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1365 cagtcgaggg catgcaaata atcatagccc rcagtctaca gccacaatgg acacacacag 60 g 61 <210> SEQ ID NO 1366 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1366 aaatgttcct agggatatag ataattcaca raatgaaaga gtctaatcac atacataaga 60 g 61 <210> SEQ ID NO 1367 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1367 caaaaagtct tttaaaaaaa aaggagtttc yctcaaacag cagttaactt agtaaataca 60 a 61 <210> SEQ ID NO 1368 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1368 gtagtcgctg tcatcatagt agtagcagta yatgactgta ttaatgaccc ttccccttcc 60 c 61 <210> SEQ ID NO 1369 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1369 tgggggcaaa tacatgcttc aaaatgttaa ygcacttttc acattttcta tcaaaaaaaa 60 a 61 <210> SEQ ID NO 1370 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1370 gtggcatgga gagttaaccc aagtcatagg yagaaagggc cctgccattt accctcctca 60 g 61 <210> SEQ ID NO 1371 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1371 ttgacaagac catcaacatc agacaataaa rggcagtgac cactgagaga cgggaaacaa 60 g 61 <210> SEQ ID NO 1372 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1372 catacacaca cacacacacc ctcacgccca yagcaggtca gcttcctgac actttgaaca 60 g 61 <210> SEQ ID NO 1373 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1373 gagctccctc tcagcctttt gaactgatta ygctgttatt aaactttggt ggggaaagtt 60 a 61 <210> SEQ ID NO 1374 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1374 ggggaggggc aaaaaaggta atggaaggat kgttctgtag tttaatgaaa cgtacgttaa 60 t 61 <210> SEQ ID NO 1375 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1375 tggaagataa atcagatgtt ggttatggac raagtatttc ttcttcatct tccttaagaa 60 g 61 <210> SEQ ID NO 1376 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1376 caaacagaat taccctcaca tctcaactga rtcatgcaat taattaccca gaaatctccc 60 a 61 <210> SEQ ID NO 1377 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1377 gagcataagg catcagggga agcttaggga rgaaagtgag gcttgatctg aatttggact 60 t 61 <210> SEQ ID NO 1378 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1378 tagagggaag ggtagaagaa aggacctgac rggagttcaa tctaggaaga acaaaaagaa 60 g 61 <210> SEQ ID NO 1379 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1379 tgttaaatga cgtgaaagga aaaaagtggt yatcatgtgt gagacattat tatgtccaag 60 g 61 <210> SEQ ID NO 1380 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1380 ctcaatcgac tgattagtcc atcgcaaggc ytatctaatt aacttctaga ttcctctaaa 60 a 61 <210> SEQ ID NO 1381 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1381 gatcttctta aagaatccac aacggttatc mgattaaagc tgtgacccat ccccagctca 60 g 61 <210> SEQ ID NO 1382 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1382 tcactttgta ctggcaggct cgttttacct sattctagaa tatttaagaa tctaaaaata 60 a 61 <210> SEQ ID NO 1383 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1383 agatatcaaa cccatcctga ggaagctccc rcgtatcaag aaacacttgt taaatggtga 60 t 61 <210> SEQ ID NO 1384 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1384 cttactccgg taagaggaag ctaacgctga yggttgtttg tttagaggga tctgtagcaa 60 a 61 <210> SEQ ID NO 1385 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1385 tcaccagcct ggccaacatg gcggaactcc ractttatta aaaaataaaa aaaattagcc 60 a 61 <210> SEQ ID NO 1386 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1386 tataaaagtg agccactgcc tggtcgagat mtttttaaat aatccattca gacaaaaata 60 g 61 <210> SEQ ID NO 1387 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1387 tgtagtgtat gcgtagcctc tatctcgtat ytttttctat ttctcctccc cacaccatca 60 a 61 <210> SEQ ID NO 1388 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1388 tacgtttcag gctcttttgt gtgtgtcact ktggggtttt tatgaagtag gctgtcttgt 60 t 61 <210> SEQ ID NO 1389 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1389 acatttgaat aagactccaa aacgttgaat rtatgcatgg atcataaatc taaataacat 60 a 61 <210> SEQ ID NO 1390 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1390 acaaattaat tacatttcat ttcatgagac rcataacaca agtgatctta tctctagttc 60 t 61 <210> SEQ ID NO 1391 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1391 aaaagaacgt tgaggataag gagatctttg ktgaccctat gcatttaaac attttaaatg 60 g 61 <210> SEQ ID NO 1392 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1392 agtcaggatc ctgtaataga ccaggtatga raaggttggc ttggactaaa gtgatattgg 60 t 61 <210> SEQ ID NO 1393 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1393 tggctagaca tctccaggtc tcaagaacat ygcagcatgc cctttgtgcc agctgtttgg 60 g 61 <210> SEQ ID NO 1394 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1394 acaatgatgc aggcaccttt ggggaagtca rctacttctt cagtgatgac cctgacaggt 60 g 61 <210> SEQ ID NO 1395 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1395 acacaccagc tgacagccag tcagtgaaca rtgtggaaag gaagataggc atgacggcca 60 a 61 <210> SEQ ID NO 1396 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1396 acaccaaaac aagctttgat gaaaagaccc rtttccctgc tgtcccttga ttttcaggca 60 a 61 <210> SEQ ID NO 1397 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1397 aggagccagg ggtctgcagg ctgaataact rggattcgca gttctgatca gttcacagcc 60 a 61 <210> SEQ ID NO 1398 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1398 agtaaatgat aggtataaag agccactagc yatgaaaatt ccctttcaaa aaaagcctag 60 t 61 <210> SEQ ID NO 1399 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1399 ccctgggcct ggtagttaaa gactgacccg sacttaatcg gttatgttat ctatagatta 60 c 61 <210> SEQ ID NO 1400 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1400 ccatggccat gatcaacaaa gtgctatggg kacatggcta aagaatcagg agcccatctg 60 g 61 <210> SEQ ID NO 1401 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1401 ctttgtttca ttctgactgc ttagtgccta stcttgggct aagggatgct gacaagctag 60 t 61 <210> SEQ ID NO 1402 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1402 cttaagaaga atttttccat gatgtgatga yagaatttgc agccagcaaa ggggatcata 60 g 61 <210> SEQ ID NO 1403 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1403 gtctgtgcga tcttaggtaa gccacttaaa wgctctctca gtttcctcta ctataaagtg 60 g 61 <210> SEQ ID NO 1404 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1404 gttttctatg tctttttctg tggctccttg raaatgttaa aggcatgtct cagctacagc 60 a 61 <210> SEQ ID NO 1405 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1405 tgatgaaagt tcaccattgc tagacttgat mtcttctaat ccttaaacac tagagccaga 60 t 61 <210> SEQ ID NO 1406 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1406 acagcaagtg cttgctaagg ggtgttactg kcagcttttc tctgagtcca actcccatca 60 c 61 <210> SEQ ID NO 1407 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1407 tcagtgaatg gtgatgatga tgcagatgac ygaaaatgat aatggtaatg atgacaaatt 60 c 61 <210> SEQ ID NO 1408 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1408 gctggctgct gtggggagtc cccttggtta yatcttccca tctgtacaga cagcagcagg 60 t 61 <210> SEQ ID NO 1409 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1409 tcaagagatc taaatctggg tcagaactca ytgaatactt agctgggtga aattgaccaa 60 g 61 <210> SEQ ID NO 1410 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1410 tcatatttag tggcaaggca ctgtagcttc kgaagtcggg cttgtccatc gttaaagcct 60 g 61 <210> SEQ ID NO 1411 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1411 aatgtttcta aaaagtagat gcattcattt mtttccctgg catttcttga ctgcttactc 60 t 61 <210> SEQ ID NO 1412 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1412 cctggatctc taattcacta cttgaataaa rctagtcatt tgctacctta aacaggaaat 60 a 61 <210> SEQ ID NO 1413 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1413 ggcaaaggga ggaaagaaac aatgaatgac sagaacaaac atatgccacg caattctgaa 60 t 61 <210> SEQ ID NO 1414 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1414 gcattcctaa gacagaaatt tgccaaaaga ytgttgtaag tttaatgagg gaagagtcca 60 g 61 <210> SEQ ID NO 1415 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1415 agcattcaaa ttggtttaca ttgtgaaatt ytgacttgct cttacatata gaaatcatgt 60 c 61 <210> SEQ ID NO 1416 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1416 tttacaaaga actattagtt atgagcaaat kacctggtga gcacaccaaa catttagcca 60 t 61 <210> SEQ ID NO 1417 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1417 aagcagctct tcttgtactt tacttacaac rcagttaaca tcccctttgc agcttgtaga 60 a 61 <210> SEQ ID NO 1418 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1418 agctgtgtct gctgtcacat tggctccaca ytggggctct tacaaatatg tgtcacatct 60 a 61 <210> SEQ ID NO 1419 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1419 gaaatgcaaa tcttgggtgc tggtgcggga rgatgttgta gatctgggat tctcaaactt 60 t 61 <210> SEQ ID NO 1420 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1420 ggaagatttc agagctgttt cggaggcatc rctgccataa tatactgagg gcaagaaggg 60 g 61 <210> SEQ ID NO 1421 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1421 tccttgatgg aaccaaaccc agatcttctc yggcaatgga gatgccacac ataaagaaga 60 a 61 <210> SEQ ID NO 1422 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1422 aggaggaaga taaacaccat tctctgcttt yagtattata aaaccgtccc acaattccaa 60 c 61 <210> SEQ ID NO 1423 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1423 tgatgcttga aagggctgcc aatcacagta rccagttcct ctggctttgg ccataataaa 60 t 61 <210> SEQ ID NO 1424 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1424 tttccttatt taagcatctg tccaagtttg yatccgagca ttccttccct gcagggtggg 60 g 61 <210> SEQ ID NO 1425 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1425 tttatttttc ttttctgtag tacatatttg rtgtctgagg tttgtctcca actccttttg 60 t 61 <210> SEQ ID NO 1426 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1426 gttaaatggg gagatgccat gagacccaac ygctacccag agaggtacaa gccctgagga 60 t 61 <210> SEQ ID NO 1427 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1427 cttctatttc tgttctgtgc agaataaact rctctctaaa ggcctgtctc atactcatcc 60 t 61 <210> SEQ ID NO 1428 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1428 acgaggttgc tgccacttct cacatgcacc wcaacactgc tgttttacaa aaacttcaga 60 t 61 <210> SEQ ID NO 1429 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1429 caaagacagt ctatacagac cggaagagat rtgtacttct tgtacaggca acaaggattg 60 c 61 <210> SEQ ID NO 1430 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1430 agaactggtt ttgaattcca gtcctgaaac stactagctg ggtgatcttg gacaatttac 60 t 61 <210> SEQ ID NO 1431 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1431 aagaaaaggg aaaggtcgca gaaatgtaga ygtaaagaca gaggtagctg catatttctg 60 a 61 <210> SEQ ID NO 1432 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1432 aaatgagctt caataaatga agaggcatac yacattctgg gaaaggaaga gtgaatgata 60 t 61 <210> SEQ ID NO 1433 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1433 actctgagat tgtcttgaaa atcctctcac rcttcctatg acaactctca atcaaccttc 60 t 61 <210> SEQ ID NO 1434 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1434 ctctcatcac aacccaaatg gcaaagtcca ygttctctgg cagggctcag ctggggaaag 60 a 61 <210> SEQ ID NO 1435 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1435 tacaaaggca tcaagaatag agagtagttt ygttagaacg gtgggagcag gagccagcag 60 a 61 <210> SEQ ID NO 1436 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1436 cttatggtag gtaggttgca gatttgagat ygagtcttaa aaagaacaag aaagaaaagg 60 g 61 <210> SEQ ID NO 1437 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1437 caggctgggg taagttcatg ttgccacgga ytctaggagg gatctctgaa gtgtcaagta 60 c 61 <210> SEQ ID NO 1438 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1438 gttcagagac atgcaaatca aaactacaac raggcaccac ctaacagcag tcagaatggc 60 t 61 <210> SEQ ID NO 1439 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1439 gaagcagcca acactagaaa tataaacgaa kgaatcatct atacagaggt agtaattaaa 60 g 61 <210> SEQ ID NO 1440 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1440 tgacaaataa tgttatgatg aatatcctga wacttgccta ttgagcaaat ttccaagttt 60 t 61 <210> SEQ ID NO 1441 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1441 ccagtggcct ctttacttct ccttcaaaga wtacccctgt acaagtccca ggttgcccca 60 a 61 <210> SEQ ID NO 1442 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1442 tttactgttg gtatgtggca gtgaaaaata yatcagcgac taacatggtt tggggtcatt 60 a 61 <210> SEQ ID NO 1443 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1443 ctcgttattc ccatttattg tacctctatg ytttttccta atagttttac ctaatattcc 60 t 61 <210> SEQ ID NO 1444 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1444 tgggcacaat tggttttaaa gatgcttaca rccccgttat cacctcataa aatggctcat 60 t 61 <210> SEQ ID NO 1445 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1445 tctgtaagca ctctgtctct cctctgatct mtactggtct caattgttta acaactttta 60 a 61 <210> SEQ ID NO 1446 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1446 tatccagctc ttctgttaag tgtgtcaaaa ytgaagtccg agagggtaga ttgtcacatt 60 t 61 <210> SEQ ID NO 1447 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1447 ttccttatat ctttcttact catatattgg rttctatttc aacacatgct taatgaaaaa 60 a 61 <210> SEQ ID NO 1448 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1448 gtccttgcac gttttgacaa ggggagagac mtgacctgag ttttgcttta gcaaggttaa 60 t 61 <210> SEQ ID NO 1449 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1449 agtcttttca aagttgcagg agatgcagtt ktctaggctt ggtgctgaaa atatagataa 60 g 61 <210> SEQ ID NO 1450 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1450 tgacattgat aaaatccacc aatcttgttc rgatttccca gttttacttg tactcatcta 60 t 61 <210> SEQ ID NO 1451 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1451 gactgacagg aatattaaag aagagagtgg wtacaaagcg cccatcatac tttatagcaa 60 g 61 <210> SEQ ID NO 1452 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1452 atctagtggg gttcactcac ctttacaggg ractcaacgc tggtagccag ctccctattt 60 c 61 <210> SEQ ID NO 1453 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1453 cggcctgaga acacatcttt agtccagcag wtacatggca ctcatctcct caagagtcct 60 t 61 <210> SEQ ID NO 1454 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1454 ctaatggtgt gctatgtttt aatcactatg wtaaacctgg atacattgta taaccaatgc 60 a 61 <210> SEQ ID NO 1455 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1455 ttccggatct cctaggatag ttacatacgc rctatctgtt ggaacttgta gaattttctc 60 c 61 <210> SEQ ID NO 1456 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1456 agggcaaaga gaagggaaaa cctagaaaac ygagtcaaga gtcctgttgg atacagtttc 60 a 61 <210> SEQ ID NO 1457 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1457 gaggctttca aggcctttgt gatctgaatc rtattagctt ctcgtgtatc tgttgctgct 60 c 61 <210> SEQ ID NO 1458 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1458 gatatggtca aatctttgga gctccagggt rtataagaca atgatacctc ctccccagtt 60 t 61 <210> SEQ ID NO 1459 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1459 acacctcatt gtctcaccct gcccaacatt yggtgtggaa gattgagaat aatgtgaatt 60 t 61 <210> SEQ ID NO 1460 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1460 ccgtttataa agagatagct tgtgtagctt stctataggt gcccctagat acagccatac 60 t 61 <210> SEQ ID NO 1461 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1461 ttagatttgc ttagccttga cagaaatact rggaaagaga caattatggc ttgccaaata 60 c 61 <210> SEQ ID NO 1462 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1462 aaaattgaat atgtttttcc tcctgcctaa racaaaacta cttaagggca aaaatttaaa 60 t 61 <210> SEQ ID NO 1463 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1463 ccatgctctt ttctactttg gggcttttgc rcctgttggt atttctgcat gaagtgttct 60 c 61 <210> SEQ ID NO 1464 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1464 ataattcaat ccagttagct cagttggcta satttttgat gcttactata ttgtacccat 60 g 61 <210> SEQ ID NO 1465 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1465 tgagctaagg gagataacac atgtaaagta ytggtcacaa agtctgcctg tattaatcag 60 a 61 <210> SEQ ID NO 1466 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1466 gttaatctca ggccctttgg attccccctg ytgttggttt cctctacgtg tttagcacta 60 t 61 <210> SEQ ID NO 1467 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1467 tagattcact aagttgaaaa gctcgtaaag rttacttttc tacaaaatac acaagcaatt 60 a 61 <210> SEQ ID NO 1468 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1468 ttctagtcaa tattttgacg cacctaacaa ygatagttaa catttacata gtgctcattt 60 t 61 <210> SEQ ID NO 1469 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1469 tcttctttta ttaccctgta aatgctgttt ygttaccctt tctcatacag gatctaatcc 60 a 61 <210> SEQ ID NO 1470 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1470 agtataatct taaaaagaga tattagttcc rtcctgcttc tctcccacca actctgcttg 60 c 61 <210> SEQ ID NO 1471 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1471 ctgaccaatg aaatagctgt acgtatttaa wgtagatcct tttatcacaa tttaaagctg 60 a 61 <210> SEQ ID NO 1472 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1472 aatcctacct gattagcatt tttagaaata yggaattgtt acatctattt cacatggtag 60 a 61 <210> SEQ ID NO 1473 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1473 tcgcaatgcc tgcatcactc acctcacttc wtcttatcat acaggcattt tgtcatctca 60 t 61 <210> SEQ ID NO 1474 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1474 ttgtttgagt aaatatgaag ttctaaggca rggaattctt tgaagagtaa gtagccacat 60 t 61 <210> SEQ ID NO 1475 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1475 tactgggata gagatggaag gctgactact yaagttacat gctcagagat gctaagacca 60 a 61 <210> SEQ ID NO 1476 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1476 tattcattca ttcatttatt caaagagtat rttatgccta ctctgtgtac agcacaatat 60 c 61 <210> SEQ ID NO 1477 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1477 tctaagtgtg agaagctctg gtgtacaagt grtgattgca aacaggggtc tggaagcccc 60 t 61 <210> SEQ ID NO 1478 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1478 gaagccggat gccactctgt cagtataaat yccagtgagg ctaatttagt ggagctgtag 60 c 61 <210> SEQ ID NO 1479 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1479 ttcatgtatt tacagagttg tgcaatcatc rctgtaacct aattttagaa tatatttatc 60 a 61 <210> SEQ ID NO 1480 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1480 tgaagtaaag agactggcgg gtagaaaggc rtaggataga gtcatagagt cactcagcag 60 a 61 <210> SEQ ID NO 1481 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1481 acaagacaga ggaccaggca ctgctcctag rtttaggcct gaaggatgct aagtgggtga 60 t 61 <210> SEQ ID NO 1482 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1482 tatttcaaag acagggtctt tgtcctttta wgactactca cttagcctaa tatcctcaac 60 g 61 <210> SEQ ID NO 1483 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1483 gagataattg gggtttctca tcagttgact kgagttgatc agagcccaga ttatactggg 60 t 61 <210> SEQ ID NO 1484 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1484 ggcccgaatt ctgtttagca cagagaagct matttatggt tgggtttttg gcttaaatcc 60 t 61 <210> SEQ ID NO 1485 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1485 agtatacacg caggtggata aaataaagaa rgtcagttta agtaagcacg cagtagccat 60 g 61 <210> SEQ ID NO 1486 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1486 taaagtacac atggcaagta ttggttgata mgtagtttgt tgtcaattat agaaacaatt 60 t 61 <210> SEQ ID NO 1487 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1487 catcggttca agaggctaac ctgtcttcac ygaattactt ttacaacttt gtacaaaatc 60 a 61 <210> SEQ ID NO 1488 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1488 gggtttgtct ttattttaac gaactcaaat mtctaccagt gctgaggtga ctacccaggg 60 a 61 <210> SEQ ID NO 1489 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1489 tggatgaaac catcttagga gtgtagaaaa rtaataggag agttccagaa actggatcca 60 g 61 <210> SEQ ID NO 1490 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1490 tatattgaga ttaatacatg aaaatgctta raagtgatag gaattattga gaaacttatg 60 a 61 <210> SEQ ID NO 1491 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1491 ctgacagatg caaagtttgg gttgttgtga yagttaccag tgtgggttca agtcttcact 60 c 61 <210> SEQ ID NO 1492 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1492 cctctgcaat ggggtccagg actgcatgga yggctcagat gaggggcccc actgccgagg 60 t 61 <210> SEQ ID NO 1493 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1493 ttctttataa attacccggt ctcagatatt yctgtatggc aatgcaaaac taattcatac 60 a 61 <210> SEQ ID NO 1494 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1494 agtgagtggt tagtaaacaa aaggaagaat saccttggcc ttagggttat aaccagacac 60 a 61 <210> SEQ ID NO 1495 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1495 ataaaagagt ggtaccatgc atcagaagta rgtcctagaa tgtgacaggt gaggtatggg 60 g 61 <210> SEQ ID NO 1496 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1496 tgttagaaaa gggctctcat ttggagaaat sagacgcatt caaataatat gaactggcca 60 g 61 <210> SEQ ID NO 1497 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1497 gagagatttc attacagtca ttctgttttc yttacttaac caaagcattg tacaaggaat 60 t 61 <210> SEQ ID NO 1498 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1498 gcagtttaaa ggatcaaatg agataatgag ygttaaggtg ttttgaaaaa catacaactg 60 c 61 <210> SEQ ID NO 1499 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1499 cttgcgaggc cctccaccca cctgttgaca rtctgggcat cggtgccttc acacatgctc 60 c 61 <210> SEQ ID NO 1500 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1500 ttctaggatg gtagagagta gtcttcagcc ygagagccat ccctagggaa gtagctgaat 60 t 61 <210> SEQ ID NO 1501 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1501 tttatctgtt tataagtacc aatacatcca rttccagtaa tgtgccacat atttgccaac 60 t 61 <210> SEQ ID NO 1502 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1502 ttgaattgta tttgtttttt ctgcagttgt rgcacaatac tggcacatag tgagcaagta 60 g 61 <210> SEQ ID NO 1503 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1503 cttcatgaga ttttgaagaa ttaattggga rtgtcaagga ttaaagttga gctgtcattt 60 a 61 <210> SEQ ID NO 1504 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1504 attgtggcaa agacacactt gattccagca sttacaatct agcatgtgag acaaacagtt 60 a 61 <210> SEQ ID NO 1505 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1505 acgaggtata tcaggttgag ctatactggc yattacactt tggatactac tctaaatctc 60 t 61 <210> SEQ ID NO 1506 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1506 aaagctaaag atctgagggt ttttaaacct rcaaatcaca ccaacttcag tcaggctgtc 60 g 61 <210> SEQ ID NO 1507 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1507 caattttttc agtgtctcca agtcatagct sttctttcta taaagtgaag aaaataaata 60 t 61 <210> SEQ ID NO 1508 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1508 aatgagtaag aagtgaggag gtgctctttt sagaagtgtg gtaagagaag acctttttga 60 a 61 <210> SEQ ID NO 1509 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1509 agtacagtat tataatctta tggtaccaca rtcatatatg cggcatatct ttgatggaaa 60 t 61 <210> SEQ ID NO 1510 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1510 aataaatatt ttacctatat gaaatacagt kgccaacttc tgtcattact taatagttac 60 a 61 <210> SEQ ID NO 1511 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1511 atttcattta tcctccaaag gaccttatga katgggcatt gttatattac acgtgaaaca 60 a 61 <210> SEQ ID NO 1512 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1512 aggctcataa ataaaacatt tccttttgta ygagctgaga gtataaatct tgagacagaa 60 a 61 <210> SEQ ID NO 1513 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1513 tcgtattgga agctttagcc agaacattca kgattaaaat cttcaatgac ccttttacaa 60 a 61 <210> SEQ ID NO 1514 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1514 tattttttca gtatattcta accaatactc wtttctgacc ttcagaaaca catgtctaat 60 a 61 <210> SEQ ID NO 1515 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1515 gataggcatt gattacctgt atgtgaacat mttctgtaga gtgaataacg tgttaaaaag 60 t 61 <210> SEQ ID NO 1516 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1516 agtagatata attcaaagaa acataagaat wagtatggcc ctgttgccat tgtaaagact 60 t 61 <210> SEQ ID NO 1517 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1517 attactgttc cattgatgaa tcatattatg magtgtttga ccacaaagac tgcgtctgat 60 g 61 <210> SEQ ID NO 1518 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1518 aagcaaattg ctatttgggg accatagaca wgaggtaagg ctgtaagcag agatagccca 60 t 61 <210> SEQ ID NO 1519 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1519 tcatttcctg atcctattat tttgactcat rttagcccaa gaagagtatt cagtacttca 60 t 61 <210> SEQ ID NO 1520 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1520 aacattaaag aaaataacat gtatatactg yactcatgtc ccagtaacaa tctaacaaaa 60 t 61 <210> SEQ ID NO 1521 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1521 acagaaaatg ttgactattt gcaatggaac ygaaagtgaa aatacacaag gaggaaaaca 60 g 61 <210> SEQ ID NO 1522 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1522 ctcttgaaac tctttcacct tttgatcttg rtgacaaaca cattctaggc tttcctctta 60 c 61 <210> SEQ ID NO 1523 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1523 ccaggggggc actttccgaa cactacttat ygaagattgt gagacaatga cagagagcca 60 a 61 <210> SEQ ID NO 1524 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1524 acttttacct ttgtgttttg actgttctaa rttatgcaac taatttgctt tgcattattt 60 a 61 <210> SEQ ID NO 1525 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1525 tggatttggt atctgggctt gcaggtccct rgtatagagc aatttgggca gtacctaaga 60 t 61 <210> SEQ ID NO 1526 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1526 cctatacatt tcttatattt ttgcaaagat sagttttaaa tttcagtgtg gtctaatttg 60 t 61 <210> SEQ ID NO 1527 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1527 gatagctaag cttcaggata taactcaaca matgaggaga gatttacatc cacggatgct 60 g 61 <210> SEQ ID NO 1528 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1528 tggatgaact cctttgccca cgtttctcag rtatttcatg ttaatgtcat gtatattctt 60 t 61 <210> SEQ ID NO 1529 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1529 taaaaagcta aagacaaaca ggctaaggat kacttcttgg tatcgaaatt tgacccattt 60 g 61 <210> SEQ ID NO 1530 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1530 ctgatatttc atctagactc aagcctcaca raggacttac atgtgtatcc aaatagtttt 60 c 61 <210> SEQ ID NO 1531 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1531 aagaattcac aagacatcat ctgctctaat kcaggtaaga agtataccct gtgaaaattg 60 t 61 <210> SEQ ID NO 1532 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1532 aagatgaaag gatatgataa gttcaggtaa ytgtttcatc cagcttatgt atatccaagg 60 t 61 <210> SEQ ID NO 1533 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1533 tgcaatttgg gatgcatgtc tttgtctaac rtagataagt agattcacat tttgcagggt 60 t 61 <210> SEQ ID NO 1534 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1534 ccacctttcc tctccaaaag aataagaagc raatcaattg tgaagatgga gcaggtgctg 60 t 61 <210> SEQ ID NO 1535 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1535 aagtaaggtt ttacatgtca ttatacacaa ytgcagagtt ttttgagagg ctctaatgaa 60 a 61 <210> SEQ ID NO 1536 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1536 agttgagggg aaaagccctt ttaacctgtt watgactgag gttagacttt tttgaatttt 60 t 61 <210> SEQ ID NO 1537 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1537 gaactgtaaa tagttcatca ctgagataca mgctttgtgg gacagaagtg gagaatgttg 60 t 61 <210> SEQ ID NO 1538 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1538 ctcaaagaag tctgaattat cgtaggcctt yacatatcac atatcttttt gttctaaatt 60 t 61 <210> SEQ ID NO 1539 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1539 ttatctccta tatcctagga ttttgcgctg ygccaagcat acagtagaca ctccattagt 60 a 61 <210> SEQ ID NO 1540 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1540 gtgtattctc ttattgttgc tgacaattaa rccacatagc atttatatag gctggtggaa 60 g 61 <210> SEQ ID NO 1541 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1541 ttcaggggaa gttgtatgct gagataccag ycagatttct gttagaggcc ctgcttggaa 60 g 61 <210> SEQ ID NO 1542 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1542 gccaaggctg agtgatttag gagtcatgat rctggagaga ctcaagcccc actcccttcc 60 t 61 <210> SEQ ID NO 1543 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1543 ttgggtaccg gagggccgct tacgcaattc rcaagtgaac gaatttgggc gcccatggcg 60 a 61 <210> SEQ ID NO 1544 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1544 ccttaagtat ttatttatat gtgttgggaa wgtttcaaga cctgtcttct agctattcgg 60 a 61 <210> SEQ ID NO 1545 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1545 gtcttgagta tctgtaagtg aatactggta rtcagcttgg ggtggagaga aagtgatttg 60 a 61 <210> SEQ ID NO 1546 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1546 ttatcccctt atccaggaaa gttaacagaa ragacacgtt aagagaagaa aatattctct 60 a 61 <210> SEQ ID NO 1547 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1547 aaaaaattat ctttgccact tttacaactg wcattcacaa attattaaac atgctttaaa 60 a 61 <210> SEQ ID NO 1548 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1548 ctgcagaaaa gtttctgtaa gcctgcctcc rgttgaccat gtggtacccc actgagcaga 60 c 61 <210> SEQ ID NO 1549 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1549 tctctgagga tatctggcat ctcttcctat stctgtgacc tttcttttct ttgccccctt 60 g 61 <210> SEQ ID NO 1550 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1550 atcctttagg ccttaacctg tgttgctaaa yggaccttca gaactccacc taacatgtca 60 g 61 <210> SEQ ID NO 1551 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1551 tcttcctgaa ccaaaacacc tactcaagaa ytcctataaa cttccttacg ctttgtttta 60 a 61 <210> SEQ ID NO 1552 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1552 ctcacaaaag gcttagtgtc atcctaggag yaattagtga gttctcacac tatcagttct 60 c 61 <210> SEQ ID NO 1553 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1553 attagtttag aaatataatt caggaagcaa ratggaagac ataagaaaca aggcagagac 60 c 61 <210> SEQ ID NO 1554 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1554 agtgggaagg aaatgggaca gatatataga rgaatagcct atgagagctg tgtgaccatc 60 a 61 <210> SEQ ID NO 1555 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1555 ccatgaagct gtgtgctgtt agcaaagccc rttatgagaa taactgagag agctgacaat 60 a 61 <210> SEQ ID NO 1556 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1556 ttcaatattt cctcatgtgt tttccaggta staaagtccg tttatgtatc tctttcattc 60 t 61 <210> SEQ ID NO 1557 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1557 ctgacttatt gcctcaaacc tctacactaa yttagaagag aagaggcatg tacactttca 60 g 61 <210> SEQ ID NO 1558 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1558 aatatttgta ttctcatttc tatagcagta ygatcaccat agctgaaata tggaagtaac 60 c 61 <210> SEQ ID NO 1559 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1559 tacatattca ttcattgtct tttctgaaaa yggatggcca agattctaaa acactcaatt 60 c 61 <210> SEQ ID NO 1560 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 60 catgttaatt tttgactgga ctaagtcaca naacagttca gtcatatgca atatttttta 60 t 61 <210> SEQ ID NO 1561 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1561 tatatttggg ctgataatgg tgtcaaacca ragagactag ctgacagcat cacactacag 60 g 61 <210> SEQ ID NO 1562 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1562 gcgtctgctg ggatacaatc agagaccagc mgctaacctc agggctttca gaaaataacg 60 g 61 <210> SEQ ID NO 1563 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1563 ggcacagcac agcttcccag gtgtaacaac ktggttggga taggagaaaa cggttgctcc 60 t 61 <210> SEQ ID NO 1564 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1564 gagcaggtga ttaaacctag caatggttta yatagagatc aaggctataa aggctgtgaa 60 a 61 <210> SEQ ID NO 1565 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1565 aatatttcta aaaatatatt ctaaaaacta yactttcgcg ttgaacattt tattccaaaa 60 t 61 <210> SEQ ID NO 1566 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1566 gaggagctca agccctgctt caggtggaag sgcagttgcc tggccctagc caggatcaat 60 g 61 <210> SEQ ID NO 1567 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1567 actaaaaata tatgctactt tgcaagtacc rttatatgcc acgctagaga tttcacattt 60 t 61 <210> SEQ ID NO 1568 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1568 ctacgtcaaa cagataatag tcagtattaa rgaaacctaa aagaacatac atatagaaac 60 t 61 <210> SEQ ID NO 1569 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1569 agacagtcaa ttcaaagtct gccatagcat mcctaattac atccctattg ccccttttct 60 a 61 <210> SEQ ID NO 1570 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1570 caacccacct acaaagcact tttaaacttc rtcagacctg cattaaccta ttgtcaacct 60 a 61 <210> SEQ ID NO 1571 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1571 ggtcatatga tagatttatg tttgacgtaa raaatggcca ggttgttttc cagggtaggt 60 g 61 <210> SEQ ID NO 1572 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1572 gcgaaacatc tctttgcata caaaggtact rtgattcgat ctccccaacg atttttaata 60 a 61 <210> SEQ ID NO 1573 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1573 tgcctctcag gcaaatctcc ctctgctctc rtcccacgaa aagggggtgc ccaattccag 60 t 61 <210> SEQ ID NO 1574 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1574 gcttgtctct taacctctgg gcatctgttt satcctctgg gaacactgtt tctattccat 60 g 61 <210> SEQ ID NO 1575 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1575 catactgtgt tccaagtctt atattaggta ytgaaatgac tgtagtgaga agaatgaaaa 60 g 61 <210> SEQ ID NO 1576 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1576 ctgcttacat actaactacc caagcctttg mtgcctagta ctggcaacat ggttaaacat 60 g 61 <210> SEQ ID NO 1577 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1577 agctgtctta tgtttagagt agaatccaaa ycacttatca taacatataa gggccaatgt 60 c 61 <210> SEQ ID NO 1578 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1578 acctaatttt tggtattcat ccatttttcc kgagaacaac acttttctca ttcttgctgt 60 c 61 <210> SEQ ID NO 1579 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1579 atcagatctg aaggtagtcc tgagtacccc yaacatacat agtatagtca gaaaaagttg 60 g 61 <210> SEQ ID NO 1580 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1580 attctgattt caacttattg ctcttttggg ktgaagtgga agatcctgaa tgactgctca 60 c 61 <210> SEQ ID NO 1581 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1581 tttctgactt ctgtgatcaa gaacagatta ytgagtctgc agctcccagc atgagcgatg 60 c 61 <210> SEQ ID NO 1582 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1582 aatacggtca gagagacaag aagagaacaa ycaaacagta tatttggcac tgtaaggagt 60 a 61 <210> SEQ ID NO 1583 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1583 aatctcagaa aaagatcacc cgtaagcata rtagtacagg ggtagtctga agtttgacta 60 a 61 <210> SEQ ID NO 1584 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1584 tcatttgata tacatactat attaaggctg yagttgatac cctgacaagt atgtaattca 60 t 61 <210> SEQ ID NO 1585 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1585 actctggttt gaccattacg ttgtagcgtg kttagcaact gtggttgtgt tggggtttgg 60 g 61 <210> SEQ ID NO 1586 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1586 aagaacccag gttaagctgg tagttgtaca rgcgaatcag gtataaagag cagatgaact 60 c 61 <210> SEQ ID NO 1587 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1587 ctgcattcat tcagagaaga tcctttgaca rctagtgaga tcccaggcac taatttgtca 60 t 61 <210> SEQ ID NO 1588 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1588 ttaggaattc agatggtagc aatgggtagc ktatactcag taagagagga acacaggtga 60 t 61 <210> SEQ ID NO 1589 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1589 gtaggagttt taagttgctc ttaggtggtt yttattcgct gcaggttatg ttagcttatt 60 t 61 <210> SEQ ID NO 1590 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1590 tgatcaatct ttgccaggtt agtcatgaaa ytgattcttc tgaaaagcta gatacacttc 60 c 61 <210> SEQ ID NO 1591 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1591 aagcaaaaga atattggagg caaaacaaca ycatattcaa gactcttctg atcttagaca 60 a 61 <210> SEQ ID NO 1592 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1592 agcaatatgc atcttgatgt aaagatttgt yatggaacac aaccaaactc atttaaccag 60 t 61 <210> SEQ ID NO 1593 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1593 ttattccaaa atgttaaaga atgctatttt yccctacact tagaatcaga gtaccagtaa 60 g 61 <210> SEQ ID NO 1594 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1594 attagtgctg ttttcctgat tttactatcc yttaacatta tccaagaata ccaatacatt 60 t 61 <210> SEQ ID NO 1595 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1595 tcagttaaca ttcttgagaa ggagataaac mgtaagcaag tgaacaggca cgtaaataat 60 a 61 <210> SEQ ID NO 1596 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1596 acttcagcta aattgttcta agttgttgat ragttgaaaa tgctctgcta acattttctt 60 t 61 <210> SEQ ID NO 1597 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1597 ccctcaaaga ggtgaaaact aaaagttata ygtgaaatgg ttatttagaa taccaattta 60 g 61 <210> SEQ ID NO 1598 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1598 tttgagacct accaagcttt gtgttaagag ygaaacctgt aggcaattaa acatttgagc 60 c 61 <210> SEQ ID NO 1599 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1599 ttattcctcc attattagac catttgcctt sgtaaaagaa ctaattacta aattcactac 60 c 61 <210> SEQ ID NO 1600 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1600 cactaaataa aaatacaaat tgtcaccaaa rtatctgttt ttcctccttc catttctcct 60 g 61 <210> SEQ ID NO 1601 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1601 ctaaggaaat gctatgaaaa tcagtgcaca wctattcaca ttcccctttt tccttctaaa 60 a 61 <210> SEQ ID NO 1602 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1602 gttttctcca taaaaatgct gaacatctgg statttgcgc ccatacaggt gattggctga 60 g 61 <210> SEQ ID NO 1603 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1603 acaggtgatt ggctgagttt gacccctttc rtctggtagt ttggcatgag gaaaacactg 60 c 61 <210> SEQ ID NO 1604 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1604 aactaaaaca ggcccgttat tgtgtagaaa yagatgtgcc taaaggtgtg gtccccaaat 60 g 61 <210> SEQ ID NO 1605 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1605 taaataaaaa ctagcccaac tttttctcta yatacctttg gctctttttt tttttttttt 60 t 61 <210> SEQ ID NO 1606 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1606 gaatgagcca tttcttttga cccatttttt yctacttgcc agttctattt acattctcta 60 t 61 <210> SEQ ID NO 1607 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1607 ttttaaagac cccctcatgg tgacacggag raggagagcc agttgtttca aacacagctg 60 c 61 <210> SEQ ID NO 1608 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1608 ggcacacctt aggggaggat gtagctctca rtcatgaaac taacacattt ccacatttct 60 t 61 <210> SEQ ID NO 1609 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1609 agcattaatt tacttattca tcaaatactt wttgagcata ctgagtacca gccattgtgc 60 a 61 <210> SEQ ID NO 1610 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1610 ttttttcttt ctttgttctt gtttttctct rttctctcag tagtctacat ctccttggaa 60 a 61 <210> SEQ ID NO 1611 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1611 tattctcttt agctcacagg gcttcaaaaa ygtctatgct atccttcttt cagagattat 60 t 61 <210> SEQ ID NO 1612 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1612 ctgttttcca tagcagctgc actattttac mttcccacca gcaatgaaca aggattccaa 60 c 61 <210> SEQ ID NO 1613 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1613 aagcaaagga gcttcctaag agaagataac rcgctgagcc atgcccatgg cctttgcctc 60 c 61 <210> SEQ ID NO 1614 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1614 tctatttttt taaacaactc atttttaacc rtcttggtga aagagacaag gacgtaaatt 60 g 61 <210> SEQ ID NO 1615 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1615 gcagtagcag cccctaattc ctagcatctt sgagaaagac tagttctcaa gaatttgaaa 60 c 61 <210> SEQ ID NO 1616 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1616 cctgcactga gtttgggttt gaagaaggcc rgagaatttc cccgagcttt ttgaatatgc 60 t 61 <210> SEQ ID NO 1617 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1617 tgaacctaat atcattttca ctcttcatgc raaccctctt gttcctgtgg ttaaagaatc 60 a 61 <210> SEQ ID NO 1618 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1618 cgtattggca cggttgtctt ccaaacccat ygatgccgga acatgggtca ggaagaacac 60 a 61 <210> SEQ ID NO 1619 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1619 tcagccagga tttgatgttt cagccttgag rtagaacttc tttcagaaac gtcagttctt 60 g 61 <210> SEQ ID NO 1620 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1620 aaatcttcat aaacactcaa tttcagttct saccaaatat ggagtcaaac caactaagcc 60 a 61 <210> SEQ ID NO 1621 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1621 ggaaggtcga tgacccagtt aacaagccaa ytggcaaatg gaacagggta tttatgaaaa 60 a 61 <210> SEQ ID NO 1622 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1622 gaagggtaaa gttaactttc taagacatac ragaggagtt gaaattagat gtgaatctag 60 a 61 <210> SEQ ID NO 1623 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1623 agatcggcaa tggctagtga catgtttgtg rgccaattat aaggtaaatg taagtcagta 60 t 61 <210> SEQ ID NO 1624 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1624 aatatacaca ttcaatgtca ccagagggaa rtggtaaaga acaacaccct ttggtatcag 60 g 61 <210> SEQ ID NO 1625 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1625 aagtctaact atcagtgagc gagcaggggg wgagcatttt ctttctgaag ggagttatta 60 c 61 <210> SEQ ID NO 1626 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1626 tgctttctgc cttctgtgtt gtttcggttc yagtgaccaa gggcacagct tggtgactgg 60 c 61 <210> SEQ ID NO 1627 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1627 taatacaatc atctgagtct tgtatggttt stgaaatgga tgctagaaga gataacttga 60 a 61 <210> SEQ ID NO 1628 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1628 ttatcaggca aggtatatgg ctggtagaaa rctctgagtc caaggcaaag tgactatcca 60 c 61 <210> SEQ ID NO 1629 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1629 ctccccccat catgactatt gccctacttt ragtagacat agattgagaa tatgttttgg 60 c 61 <210> SEQ ID NO 1630 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1630 ccctgccagc ttccccaggt ttttgtaggc rtcaaacgag acatatagga aggctctttc 60 c 61 <210> SEQ ID NO 1631 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1631 catctcccca ggcctttgct acaggttttc yagccctgga cggttcagga attgccctac 60 c 61 <210> SEQ ID NO 1632 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1632 agatcctttg gaagtcatga gcatctaagt yggtgagcta aacattagga tattaaccag 60 a 61 <210> SEQ ID NO 1633 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1633 ttatataaca gctcaggacc aagaagttag ygttgaatgg ttatgttcac atgtggtcca 60 a 61 <210> SEQ ID NO 1634 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1634 ataattcctg tattattttt tggaaattat scattctgac agaaaagagc ctgggtggag 60 a 61 <210> SEQ ID NO 1635 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1635 caccttaaaa tcctctgtat cttggaaatg yatgtcagat tggcaaaaat ttaaggtatt 60 t 61 <210> SEQ ID NO 1636 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1636 attatatgaa taaatataaa tatctacatg ygtatatgga tatggaaaat atctgcgtgt 60 a 61 <210> SEQ ID NO 1637 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1637 tgtctgtgca aggacaagga aaagaatttc yctactggct cctgccccct ctagttcagg 60 g 61 <210> SEQ ID NO 1638 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1638 aacacaggaa gcttcttgat tctaactcag rgaccctcat gaagttgaag tcaaggtgtt 60 g 61 <210> SEQ ID NO 1639 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1639 tccaagatac aaaactctcc aggttttcct yttctacctc tagctccacc ttcttattcc 60 a 61 <210> SEQ ID NO 1640 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1640 cactgaattt gtcaacttgg gtaccactga ygacaatatc cagagcagtt ttggcaaggc 60 a 61 <210> SEQ ID NO 1641 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1641 gaaaagtgga gtcctagtaa gagtgcttta sactttagga aaatcttcaa caaatatgag 60 t 61 <210> SEQ ID NO 1642 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1642 ttgggttcca ggcacagatg actggtagtg kttacctaga gttctgtgtt gagaaggatt 60 c 61 <210> SEQ ID NO 1643 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1643 ggaggcggca gcagcaaagt cccaagaaca magtgctggt gtaggagtca ggcccgcatc 60 t 61 <210> SEQ ID NO 1644 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1644 ctgaaaggtt cttcaaagtc aggtccctaa saaagctgtt ccatctccag ctcagcgtgt 60 t 61 <210> SEQ ID NO 1645 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1645 gccccagaag agaagaggct tctttctcac ygtgaggcag aaacaaattt atctgtatgt 60 a 61 <210> SEQ ID NO 1646 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1646 aagcagcctc cctctgttac tactataaac rcccattctg caggcagtgt gagggcacag 60 c 61 <210> SEQ ID NO 1647 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1647 ggtggaagca ccccacttcc tttacctggt stcccatcac ctatcagaac cagagagcgc 60 a 61 <210> SEQ ID NO 1648 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1648 agaatcccag ctcagatcca gcagaagaca yggcatgcga gatcttgaaa gatccctttt 60 g 61 <210> SEQ ID NO 1649 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1649 tgtggtagta tcgcagtgct tgtgtcgaag ycactcttat tttacctaat aatggcccca 60 a 61 <210> SEQ ID NO 1650 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1650 gtctcttatg cttctgggga gaaatcacca wctggcgagg gtttcctggc ctttgggggt 60 c 61 <210> SEQ ID NO 1651 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1651 gagcccttct attccttcca ctttgaccag kttttgcctc tcttggtggt gggtccctta 60 g 61 <210> SEQ ID NO 1652 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1652 gttagaaaag gagggaagtt acaattgcac rggggtagca tggcagactt tctggggatg 60 a 61 <210> SEQ ID NO 1653 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1653 acacagatgg gtatgggact ctgggccaaa ytgatgcttc tccaaacgat ttctactctt 60 t 61 <210> SEQ ID NO 1654 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1654 gaaagtcagt tccttgtctc tgttcttaac rccaggcctt tccaccgtat cggcaatttt 60 g 61 <210> SEQ ID NO 1655 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1655 cttttactta ttttgcccat gtccactcat kgttttttac tcattttcaa agggagtaca 60 c 61 <210> SEQ ID NO 1656 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1656 ctttcgtatg tatttgtgaa taacagaaga yacaatgaca tggtgatggt aacacatgtt 60 g 61 <210> SEQ ID NO 1657 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1657 tcctcgtgga tatagctgct catggttcca satcttggga aggacaaggt ttactcacac 60 a 61 <210> SEQ ID NO 1658 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1658 gcgtgagcca ccgcgcctgg ccgagaaatt rgaattttac atcaaacaaa aagtagagct 60 c 61 <210> SEQ ID NO 1659 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1659 gtgagaattt catggcccag atcataaggc rgagggcttt aaagttctct tcaaatcgca 60 c 61 <210> SEQ ID NO 1660 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1660 gtctccaatc ttaatgccat gcccttgggg stgtatctag gaagtggcag ctccctgcat 60 t 61 <210> SEQ ID NO 1661 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1661 tggtaaatat tttactaaac ggaatcgatc rtgtcttgaa ctaaaaacat cagcaaggca 60 t 61 <210> SEQ ID NO 1662 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1662 atttctccat gctgttactt gtattgttgc rgagtagtat tcctttatat ggatgtatca 60 c 61 <210> SEQ ID NO 1663 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1663 tactcagcaa acatattatc cagtttcttc sttgagcagg ccatatgatc atgtgatcag 60 c 61 <210> SEQ ID NO 1664 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1664 tttcttgaaa actcaagaga atcttgaaac ygctgcaaaa atatgttaac ctggtaggat 60 a 61 <210> SEQ ID NO 1665 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1665 aggccaaagt ggcaggatca cttaagcctt kgagttcaag tttacagtga actgtggtca 60 t 61 <210> SEQ ID NO 1666 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1666 aatttttttc tttgagaatt caactcgaag katagtgagg aaaatgcctg atttttctga 60 a 61 <210> SEQ ID NO 1667 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1667 atgtggttct tgagtatgtc cagaattata wggctgttaa tgtgtcttga gccctgacct 60 a 61 <210> SEQ ID NO 1668 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1668 tattgctctt tatattaaag gggttatcat rttcactctg cttcaaatgt accaaatggt 60 a 61 <210> SEQ ID NO 1669 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1669 gtttgacaca aggaagattc tgggaagttg ragaagaaca gaacctggga ttggcagcgg 60 c 61 <210> SEQ ID NO 1670 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1670 taaaaatcag aaagtatctg aagttgtttt kgaagggaac aatgtgagta caaaatattg 60 c 61 <210> SEQ ID NO 1671 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1671 gcagaagagc caaaggccct cggcagccaa rcatgttcaa cggccagtgc ccaggtcacc 60 a 61 <210> SEQ ID NO 1672 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1672 agggtcacct gggtagacac tgcccaaggc rgccgctgag ccttccccac aagaattgct 60 g 61 <210> SEQ ID NO 1673 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1673 aaaggagaaa acctgttttc tgtctttaac kgtccttccc ctcaactggg accctgtgct 60 c 61 <210> SEQ ID NO 1674 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1674 gagcagcgca cggggcttca tgtgcccact ycaggcctcc ccagccgaac atagatggga 60 a 61 <210> SEQ ID NO 1675 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1675 ttctaattgc tgacggtgtg gtagaagtta rtaaaactta gtatctccgt gttacctgtg 60 a 61 <210> SEQ ID NO 1676 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1676 attgtgtgca gcatacctag agcttacact rtgaactgta tcctaattta agctaattta 60 a 61 <210> SEQ ID NO 1677 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1677 cttttgttct gcttgctgta gatggagcag ktgaggaatg agctacttca ggagagagct 60 g 61 <210> SEQ ID NO 1678 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1678 acgtcatcaa acacatgagt ggctcagaaa rcttcatcgg gtcattattt ctttttcatg 60 a 61 <210> SEQ ID NO 1679 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1679 cagaagcatg ggggtgagaa ggaagaaata kctctggatc agtgtgggcc aaaagttaat 60 t 61 <210> SEQ ID NO 1680 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1680 aacatctagg catgtgtgca agaaattctt ytatcactgg cttctataat tgagcaaggt 60 t 61 <210> SEQ ID NO 1681 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1681 tcttctaggt cccaggaggt agtctttggc stggtgtgac tgtgactgtg tcctccagct 60 c 61 <210> SEQ ID NO 1682 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1682 aaacatgcag gaataaggtc tgggaagatg yttcaagttc tgttcaaaaa agtatatcag 60 g 61 <210> SEQ ID NO 1683 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1683 aggctggtgt gtgaggttcc taatctccca rtcacagaag aaattatgtt caagacagct 60 c 61 <210> SEQ ID NO 1684 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1684 gacacagctt aggtatgaaa atctggcaaa ycaatagtcc cccaaatgtg ttcttatgat 60 g 61 <210> SEQ ID NO 1685 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1685 aacagcatag tgacagatat ggcagagtgc rcaaaaccta aaatagtatg tggcccttta 60 c 61 <210> SEQ ID NO 1686 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1686 taactatctc atgaccgtgt ctgtgagtcc rtttttatac agtcaaggtt caaacccagg 60 c 61 <210> SEQ ID NO 1687 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1687 aaaggccata gtttttaggc ccttgctcta raatgtttac tgaatctgag tgacagaccc 60 t 61 <210> SEQ ID NO 1688 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1688 actaataata ctgagcatct tttcatatac sagatacatc ctttttggaa agcagtttag 60 t 61 <210> SEQ ID NO 1689 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1689 cagacacaaa aggccacatc ttacaggttt yacttacata caatgttcag aacatgtaga 60 t 61 <210> SEQ ID NO 1690 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1690 taatctagca gggaaaattt tcacattgga rttgagggat ctcttagact tcaccgtctg 60 c 61 <210> SEQ ID NO 1691 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1691 agaggtccct gggtccacaa cttctgttcg ytactccaca ttcttctgga ctctacccat 60 g 61 <210> SEQ ID NO 1692 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1692 tgagtttctc ttctgtcata tcacataaat kggttctgtc tagtctaagc ccagaggtgc 60 t 61 <210> SEQ ID NO 1693 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1693 ggactagcaa gtccagcctc accgtgtatc rccaaattgc tctccaaacg ataccaatct 60 c 61 <210> SEQ ID NO 1694 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1694 tgaccagtta ggaaaagaat cttccatata scctatcccc ctgcttgggt gggtgaggcg 60 a 61 <210> SEQ ID NO 1695 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1695 gatgtaaatg ttgaggcatg gaaggatctc ratgatctag tgtaaaacac cgtgtgcagc 60 a 61 <210> SEQ ID NO 1696 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1696 ctctcgcgat cagcagcagt aaacacacta rgaacgcact attaaaatga agagtgccta 60 c 61 <210> SEQ ID NO 1697 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1697 agcatccacc tttaacgaga aatcaaaaga rcaagaaacg tcatgccaat ctcctgtggg 60 g 61 <210> SEQ ID NO 1698 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1698 gtatagaacc ttcatctcac ccatgcctcc yacagcatcc aggccccacc cagtgataag 60 a 61 <210> SEQ ID NO 1699 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1699 taataagctt ccaggtgttg ttcctgatgc yggttcgtgc accagaatat gaacagcaat 60 a 61 <210> SEQ ID NO 1700 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1700 ctgtatccat tcagtagcca atgtaaaatg rtgccaaact tactatttta gattgaaggg 60 a 61 <210> SEQ ID NO 1701 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1701 ttgtggagtc agtaagatga tggtaaacag sgagatgcat ctcacaaata cccgtaccca 60 g 61 <210> SEQ ID NO 1702 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1702 aactccatct taaacataaa ataaaataat yctggatcct cctgtactac ctgtgtgacc 60 t 61 <210> SEQ ID NO 1703 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1703 gctgccggga agagagctaa taaaggaaac rgatgaggtg gtctaagggg cccagcagag 60 g 61 <210> SEQ ID NO 1704 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1704 agaaaagtga ctctcgcaat ttattgccaa ygagaaccac cacattgttc attgattgca 60 t 61 <210> SEQ ID NO 1705 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1705 cttatctgag ttcctttctt agaaaactga ygctcgggcc tcccagagag tataaaggaa 60 c 61 <210> SEQ ID NO 1706 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1706 agggctcgag ttagattcag tattcaacca rtgttgctgc ttaagcctgt aaatgtatgg 60 t 61 <210> SEQ ID NO 1707 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1707 atccccatct agatgaagag acaagtagaa rggagatgca ggcatttcta ttttcagagt 60 a 61 <210> SEQ ID NO 1708 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1708 ctgtccccat ccaggccctt tcttttggag ygttctcagt ataacccaac aggtggacac 60 a 61 <210> SEQ ID NO 1709 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1709 aggaataaaa aactcgccaa aatttcctaa sttgtagaat agaaatagtc acctccaaag 60 a 61 <210> SEQ ID NO 1710 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1710 attcttgagc aagggcacaa ggaaggaatg kttttctgct cctggatata atcttctcac 60 c 61 <210> SEQ ID NO 1711 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1711 atattgattg tctcacacag tttctgaacc rcaggaattc aggatggctt agtaggatgg 60 t 61 <210> SEQ ID NO 1712 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1712 aatggctgtt cagatttgca ttttaagtag yttactctga tcaagttgcc aagtgagaca 60 a 61 <210> SEQ ID NO 1713 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1713 gtgcttgtgt gcaacgcagc aacttttgct staccctgga gtctcaccaa agatggcctg 60 g 61 <210> SEQ ID NO 1714 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1714 tcctacggct gagaggatga aatttctgaa ygggcacttt gccgagtgag tgaccacatc 60 g 61 <210> SEQ ID NO 1715 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1715 aactctcata tattgaggat gggagtctag kagggcatac ttgctttgga aaagtttgtt 60 t 61 <210> SEQ ID NO 1716 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1716 attttattta taatagaagg aaactgggaa maaccaaatg accatcaaca gataaaggga 60 c 61 <210> SEQ ID NO 1717 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1717 atcggagcag ctgcttccac cttgctttat yttcctgcag ataatgtcct gttcccgtca 60 t 61 <210> SEQ ID NO 1718 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1718 acagcccaaa ttaagagctt ggcacccaat ycccacttgg actacaaatc acttcctctt 60 g 61 <210> SEQ ID NO 1719 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1719 ttgatcagcg gcctccctgc tcctgttctc yagatagaag tttccctagt tttgctggtc 60 t 61 <210> SEQ ID NO 1720 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1720 tttgtttgac ttaagggaaa caggtattat wtggcattcg acatcactaa tttaattaca 60 a 61 <210> SEQ ID NO 1721 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1721 gaggtgacag gggcttctgt tttcttgagt ytccctgttt gctgatgtca tcccctccta 60 c 61 <210> SEQ ID NO 1722 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1722 ccttctaagg gttagagaga caggatttta yagaatgcca tcacctgagg ctgtgacaat 60 g 61 <210> SEQ ID NO 1723 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1723 aatatacaca tgtatatttc atttatgtta ytgatatcca tctgtttcat cagctcattt 60 t 61 <210> SEQ ID NO 1724 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1724 ctggcttcaa aacgcagagc actagcattt ycatatgttt cagtaagtct cccagccttc 60 g 61 <210> SEQ ID NO 1725 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1725 ttttcatggg tagtgcttcc tgtcattcag ktctcagatc aaacactacc tctttaagag 60 c 61 <210> SEQ ID NO 1726 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1726 agcccacata agtatggcgt cttaccagta ractccgctg aatccgagga agggccttag 60 g 61 <210> SEQ ID NO 1727 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1727 tgacttattt ctccttccct ctattttaaa stcttgattc tatcatctgc ttgcctgcgt 60 a 61 <210> SEQ ID NO 1728 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1728 gctgatggaa gcagctgatg gagtggatgt rtataaggag cattgggcac cctgttagca 60 g 61 <210> SEQ ID NO 1729 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1729 cttagtgcaa atggcttcct ggtttgggta maaatttagc aactgaatgt gatcttgtgt 60 a 61 <210> SEQ ID NO 1730 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1730 agtggctctg tctaaattca aatccttcct watctaaccc ttggggagaa aacagtgtgt 60 g 61 <210> SEQ ID NO 1731 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1731 gtcctggtct gtcgctgact cttgggaact yaggtcaact cttcacctcc tggtctgtta 60 c 61 <210> SEQ ID NO 1732 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1732 tgtacaagtg ttgtccgtct aacctactta mcctttgtaa ttctattgtg atttgcttgg 60 c 61 <210> SEQ ID NO 1733 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1733 tcctattggg tcaggacttc acctgttgac stcgtttaac cttaattagt ttcatcaagg 60 c 61 <210> SEQ ID NO 1734 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1734 tcggtctgtg gtgtctggtg tgggacctca yatgaagggg gccacacagc acactccctg 60 t 61 <210> SEQ ID NO 1735 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1735 tcactgtgtc aatgcacgtg aaatgcatag racaaagaca tgtaaagata tgacctgtga 60 c 61 <210> SEQ ID NO 1736 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1736 caatgagctt aattgtgttc gcttaccaaa stcgcccccg ctcacggcga ttttagagga 60 a 61 <210> SEQ ID NO 1737 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1737 tcttttctca tagggtcagg tggctggatc staagaaatg gcctacatga cttatctctc 60 a 61 <210> SEQ ID NO 1738 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1738 aataaggaaa ggacagggca tggccacacc yaggtgtctc tgcagggttc tcttgggagc 60 c 61 <210> SEQ ID NO 1739 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1739 gctcatgtgc agagaaaatg ggatttgcca sctgttctca actcaaggca ggctctgtgt 60 c 61 <210> SEQ ID NO 1740 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1740 tcacaaatga tgagctcttt ggcatcatca rtccagccac aggagaatgg aaggatggta 60 a 61 <210> SEQ ID NO 1741 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1741 agtactcttg cagcgccccc aaaactctac ractggttca catctctgta tctttacatg 60 t 61 <210> SEQ ID NO 1742 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1742 tggtgaggga gcagaataca atttagtcca yaagaaatca taaaacacaa atatgtaaga 60 g 61 <210> SEQ ID NO 1743 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1743 aggaagaaca tggactctgg agtctgttac kgccagtttt ggttctagta cgttaaactc 60 c 61 <210> SEQ ID NO 1744 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1744 ttggaaagtg tcctacatct gggactgtta maaagataag tcaacacagg gataaaaaaa 60 a 61 <210> SEQ ID NO 1745 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1745 acagagaatg tagaggaggc aagatggata rttatggagt caaagaaaaa aagtccaatg 60 t 61 <210> SEQ ID NO 1746 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1746 aacatggttt tgaggtactg aacggcatac rtaaaacatt ttcatcagaa gggaagtgag 60 g 61 <210> SEQ ID NO 1747 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1747 atgcactcca aaatatcctt tacaatgact yaatcactct tcagtatgga agaccaagga 60 a 61 <210> SEQ ID NO 1748 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1748 tattataatt aattcaaaaa ttgtccttct wcctatcagg tcctggctcc agactacctg 60 t 61 <210> SEQ ID NO 1749 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1749 ggctgtcttc cagaaatgat tttactctac kttctgcttt catcctcacc tcttctcctc 60 t 61 <210> SEQ ID NO 1750 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1750 aatgtagaca tgcagattag tacataactt ytgttgaata tgtatagaat gtgtagagga 60 a 61 <210> SEQ ID NO 1751 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1751 atttaacata ctcaaagtga acacatttat stttcctctg caaacctgct gcttctgcat 60 c 61 <210> SEQ ID NO 1752 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1752 gtcattaggg caatgcctgt acggttcctc rcagctcagt aaaggcggtg gttgccacca 60 g 61 <210> SEQ ID NO 1753 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1753 ctgttttcca aagtgactgc aatattttgc rttaccacta gacatttttc agagttctgg 60 t 61 <210> SEQ ID NO 1754 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1754 cttgttcaag ggcacacagc cagctactag magaatctgg gataagagac atgaactccc 60 c 61 <210> SEQ ID NO 1755 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1755 cggtgcacca agctacatga cgcatctttg ytgagctgtg acggtattcc agggctgggc 60 t 61 <210> SEQ ID NO 1756 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1756 agagtatggg gaaatttcag gtgacagata yaaaggacaa atgtttaccc aaaaaatata 60 a 61 <210> SEQ ID NO 1757 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1757 tacatagttc atctgggata cagctcacaa rtctattctt taaacaatgg ttgaaaacaa 60 a 61 <210> SEQ ID NO 1758 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1758 catcttattg ctgagcgtag agttctgtac mtgattgtgt atatattgta gatactagac 60 c 61 <210> SEQ ID NO 1759 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1759 tctaagaccc ttcacttctt tctattccag ytgctcacct tagttcaggc catatcacct 60 c 61 <210> SEQ ID NO 1760 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1760 tgtgacacta catctctagc tccaaaatct rcttaggttt taaagcctct tggaaatctc 60 t 61 <210> SEQ ID NO 1761 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1761 aggcaagggt gaagacacac ctgcaggcca ytaatcttgc tacacagcat ccctatttta 60 a 61 <210> SEQ ID NO 1762 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1762 aaacagggct cttcctgatc tagctgttga ycacctcgtt aattttatca ttcatacctg 60 t 61 <210> SEQ ID NO 1763 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1763 tgaaggtatt cagcttgtgc taatagtctg kacttgtttt aaagacccag gaggtctttt 60 t 61 <210> SEQ ID NO 1764 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1764 acctttctat atctttctct ggccaataac rctgtgatgc cattaaggca tgaagattca 60 a 61 <210> SEQ ID NO 1765 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1765 ttcaaggagt ggtctaatcc ctggactgct ktctgagtat cagtaattag taagcaggcc 60 a 61 <210> SEQ ID NO 1766 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1766 cttgacatgc ttttcactgc ttacatggtt rgtttcctac ctagctgaat gcaggcatct 60 g 61 <210> SEQ ID NO 1767 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1767 aggctgttgg ttacctggcc gggagctggc rgagaccagg atttctcctc gccgccgttg 60 c 61 <210> SEQ ID NO 1768 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1768 tttttgcatg cttcaaaatc aaaaggcggc rcagtgaaaa cattttaatt atttatgtat 60 t 61 <210> SEQ ID NO 1769 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1769 acatacctga taaacgcttt aggctgatgt mcccagcttc ttacatgtca ctctgcttaa 60 t 61 <210> SEQ ID NO 1770 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1770 tgggaacctt tccatgtttt agtatgtcct rgaagagtaa aaataacact caaattttct 60 a 61 <210> SEQ ID NO 1771 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1771 tacatttagt tttgctactg tatatgagct yatgaaatgg acttcccttc cctaataata 60 t 61 <210> SEQ ID NO 1772 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1772 aacatggaca agttggaaga ggagcgactc yaaagtttgg caatggagcc cggagttttg 60 a 61 <210> SEQ ID NO 1773 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1773 tttcaaacaa ataattttcc ccacgtttta wcatctctat aatctgcata cgggttttca 60 c 61 <210> SEQ ID NO 1774 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1774 agatgggttg gggcagatcc agcagattac rttactgtga gggggtggtg gggaacacag 60 c 61 <210> SEQ ID NO 1775 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1775 actactgggg aacacatgga cattgctcct yagggcccat gtgcacctac gtggctccag 60 g 61 <210> SEQ ID NO 1776 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1776 aagaaactca catgcgtgaa ttacttcctt ygtgtcacat agtaaataga gccaggattc 60 a 61 <210> SEQ ID NO 1777 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1777 gtaaattctc aagttcttaa ggctgaatgt yatcttgtat tgtttcttgt atttgtgata 60 t 61 <210> SEQ ID NO 1778 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1778 tttagttcca actaacaaag tctcactcta wgcactcatt ttctacttct ggatgtcttg 60 t 61 <210> SEQ ID NO 1779 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1779 caaaacaaat agaagagcag tgagaatgaa rccatggtgc tatcttcgta tttatagtga 60 t 61 <210> SEQ ID NO 1780 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1780 acagctaaaa gttggacaga gtggaagact ytcagttata tgcctgatta tagccaaact 60 a 61 <210> SEQ ID NO 1781 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1781 tttctagtta ggctagaatc tttgtctttt ktaagataaa tgcggaagag taatttctca 60 a 61 <210> SEQ ID NO 1782 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1782 gacaagtatg gtctaaggaa aaaacaagga wgaactcaag caagagttat cacattggcc 60 a 61 <210> SEQ ID NO 1783 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1783 agtataggat tggtaaacct cggcgatatg wtaggttgga gccaaacttc aatgaattcg 60 a 61 <210> SEQ ID NO 1784 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1784 tgtggaactg aaatgaattt gtcaacctca sattctgaat ttagaacttt atgaagtata 60 g 61 <210> SEQ ID NO 1785 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1785 ggaactattg ccaggctttt aggagctgcc rttgctaaca aatcagtttg ggtaggcagg 60 t 61 <210> SEQ ID NO 1786 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1786 atatatccat ttgagtggat aaatttgctt ygcgtttgga gagttttact tttcacctgt 60 a 61 <210> SEQ ID NO 1787 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1787 atttccctga acttcataac ctgacaaacg ygctactcaa tccgtcattt caacaatctt 60 t 61 <210> SEQ ID NO 1788 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1788 gtaaatcata gagaattatt catggggtta maaagttagg gaatattact ttttatcatg 60 t 61 <210> SEQ ID NO 1789 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1789 gcatttcttc acctgtcaag tttagattat ytttaatgcc tcagcttcag tgttatctcc 60 t 61 <210> SEQ ID NO 1790 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1790 gaaaagttag agaatgggca ggcatcatgg yttaggcatc tatcccagca ttttgggtgg 60 c 61 <210> SEQ ID NO 1791 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1791 aaccactgca cacaatttca tgacagtgta ytccaccctt accccagagg aggttggcgt 60 a 61 <210> SEQ ID NO 1792 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1792 aagttagaaa acagacaaat tcgtggcagc rctttacata aaacaggaaa atgaatgaac 60 t 61 <210> SEQ ID NO 1793 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1793 agagagattc aacgtgtatc ttatgcctac rccaaacctg gatatttatg gtgaatgcac 60 a 61 <210> SEQ ID NO 1794 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1794 tgaaagagag tgctgtccat cattgccccc rgtgagcact gttttcattc agggtaaaag 60 t 61 <210> SEQ ID NO 1795 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1795 tgggggagct gatttattaa tctattggaa stgctccaag tcaactaatt cagccatacg 60 g 61 <210> SEQ ID NO 1796 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1796 aaggtacagt aaaaatatgg tgtaagagat waaaaatgat agagctgtct agggcattta 60 c 61 <210> SEQ ID NO 1797 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1797 tgttacattt ctggagggtg atttggcaaa rtatagaaaa gactaaaaac atgcatattc 60 t 61 <210> SEQ ID NO 1798 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1798 agaaacattg tacccattta tatccacacc yctgaaagat gcacctgaat catttgaatc 60 t 61 <210> SEQ ID NO 1799 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1799 tgtctctctg aaatttgggg tgacaatcct rgagacaaga cctaagccta gcatgactta 60 t 61 <210> SEQ ID NO 1800 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1800 ccgggcagtc agatcgctgt ggcagtagtc yagcgccgtg acacagggtt ttgttgcagc 60 c 61 <210> SEQ ID NO 1801 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1801 gccagacact actctaagca ctttgcacat mgaaacccgc tcactaacaa caccacgaaa 60 t 61 <210> SEQ ID NO 1802 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1802 actctctagt tcagatttaa gtgagcaaat rtccatcacc cagcatctca catgcataga 60 g 61 <210> SEQ ID NO 1803 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1803 gcggatggcc cagaccacga cagtgaccga rgctgtggct ttccagtggg ggagcactcc 60 c 61 <210> SEQ ID NO 1804 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (31)..(31) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 04 ggctgcagtg agatgaggac acaggagcac nttgggttag tctgcatctt ggtggctggt 60 g 61 <210> SEQ ID NO 1805 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1805 cagatcagga aactgagtcc cagaaggatt wagtcagtta cccaagttgt tctagttaaa 60 t 61 <210> SEQ ID NO 1806 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1806 acacggctgg aggccaccta cttctcacct yctgggcctg gcagcctccc ccagcctgat 60 c 61 <210> SEQ ID NO 1807 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1807 tcaggcactt aataaatatt aagggtgacc rgtgactcag gctctgcctc tgggaagtgg 60 c 61 <210> SEQ ID NO 1808 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1808 tgggctccct agggacatct ccatcaggaa katcctttgt tcctgacccc acctcctcta 60 c 61 <210> SEQ ID NO 1809 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1809 gactctttat cagttactat ggtggtaagt rcaagcaagg aagacagagg aaattctcta 60 g 61 <210> SEQ ID NO 1810 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1810 ccatggcagt ggctctgata accaagacag stcctgaatg actaacaggg ctggtagcgt 60 c 61 <210> SEQ ID NO 1811 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1811 gagaacggtc caactcaggt aggcggatga ygaaggaaga gtgggaacat ttacaaagaa 60 g 61 <210> SEQ ID NO 1812 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1812 tttaaaaagc tctctagatg attctgaagt rcaaccatgt ttgaaaatca ccatcttaaa 60 g 61 <210> SEQ ID NO 1813 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1813 tagacgagac agaaagacaa agcaagacaa ygacagagat agaaaataca ggagacagaa 60 a 61 <210> SEQ ID NO 1814 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1814 gagaacagag agaaggccct ataaaggctg ytctatgggt ttttggtagg ggaggaggaa 60 g 61 <210> SEQ ID NO 1815 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1815 catattctgg gtagtgattt ttgcctctta mcttacttga tattttaata aactcacata 60 c 61 <210> SEQ ID NO 1816 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1816 gctgtaatac cgcttatttc agtatactta yctcacaggg tagtttgaag gtaaatttaa 60 t 61 <210> SEQ ID NO 1817 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1817 ctcaacagat ggtgactcct ggcactgtga ytccgttctt aaaaaggcgt tatattattc 60 a 61 <210> SEQ ID NO 1818 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1818 aaggtgtgaa actttaaggg cagacattag raaagtcttg ggcaacctgg atggttggtc 60 a 61 <210> SEQ ID NO 1819 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1819 actacaacat ttatgttgca cttatccaaa katttgacca gaatagaaaa tgccccttcc 60 a 61 <210> SEQ ID NO 1820 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1820 tcagctgcat ccaacgtcca ctgagagcta ytgtgggcta aagatggttt ggctgagagt 60 g 61 <210> SEQ ID NO 1821 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1821 gcaagtttct gcctctgctc ttcaatctcc rtgcccaggg tggagtgcct ctgcagcgca 60 g 61 <210> SEQ ID NO 1822 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1822 ttttaatctc ttctctgtcc tgctttcaag staagctcag ttttacactt atagaatcca 60 a 61 <210> SEQ ID NO 1823 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1823 ctttcacata aaattggagt agggtgggag ragaaccacc agcagcggca aaatgaggtc 60 t 61 <210> SEQ ID NO 1824 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1824 tgcgcattac tggaacaatg actgactgat rtaaaacgct aacagcagaa atacgggaaa 60 g 61 <210> SEQ ID NO 1825 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1825 acttcaagta accaaacaac tgtgaaagaa rgtttctcct ttagagatat tccagctaaa 60 a 61 <210> SEQ ID NO 1826 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1826 ctctaccacg tcagagggag ctacaaggtt yggaggatgg attcagagtg cacatagaac 60 g 61 <210> SEQ ID NO 1827 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1827 tttttttaaa gcaaaggata aatttgtgga saagtgacag gacaaatggg tttaggcagt 60 a 61 <210> SEQ ID NO 1828 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1828 agttatacca gagctgaact ccttgaagga rgtgtgtagg tctctcaggg actgctcttg 60 g 61 <210> SEQ ID NO 1829 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1829 gcgaaagaac cctggtgtgg gcaacggaga ygacgaggca gctgagttga tgcagcaggt 60 g 61 <210> SEQ ID NO 1830 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1830 ctagcagtag cctcaggaag aagagaaaaa ygtggatctt ggtaaaatac agcagtgcct 60 t 61 <210> SEQ ID NO 1831 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1831 gaaactcatt cctgtatccc taatagtaaa kagagtgcct gacacatagc agcctggtga 60 a 61 <210> SEQ ID NO 1832 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1832 gtagagactt agcaaatgtt ggttccctct yattgactca ctcacacttt ggacaagacc 60 c 61 <210> SEQ ID NO 1833 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1833 gtctgtgacc cacacgttaa tatggcctca ytttgactaa gaccactatt cgagtaggtt 60 t 61 <210> SEQ ID NO 1834 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1834 tgatatataa caaatgcaga ggtagcctca ygcattaaac gtctttttct tgctgatgga 60 a 61 <210> SEQ ID NO 1835 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1835 cttgtgcagc cctggcctcc ttttaatgtc yagaccagca tttctcaacc tcgacactac 60 t 61 <210> SEQ ID NO 1836 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1836 catcgggaag ctggggtaca tgttctgcta maacagggaa cacagctttt ccaaacatat 60 c 61 <210> SEQ ID NO 1837 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1837 gacactgggt cttcacacac acagcaagga ytgttaattc aaatgttcca gcacgtgaag 60 c 61 <210> SEQ ID NO 1838 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1838 tgttgtcata cttcaaatca tattccaaat ragcatcaaa aataataaca tgcggccggg 60 c 61 <210> SEQ ID NO 1839 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1839 ttctcatctt tcttggaaag tgggatgaac ragcagaaat aacaggaagg caaattcaag 60 c 61 <210> SEQ ID NO 1840 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1840 gtctttgcag atgtaactaa attaagatga rgccaccctg aattaggatg tgtcctgaat 60 c 61 <210> SEQ ID NO 1841 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1841 tgccccttcc ctctacaaaa ccatcagctc ygtgcaaact gggatttttg cctgaattgt 60 t 61 <210> SEQ ID NO 1842 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1842 agataacacc gcccagcctc ccctgcagct rgatggaggt cacatgcttg gatctggtca 60 a 61 <210> SEQ ID NO 1843 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1843 ctgtgactca agggcagcca caactctgtg ycagccataa ttgccatgcc atgcaagaat 60 g 61 <210> SEQ ID NO 1844 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1844 ggtctccagc ttcccagccc tcagcatgca mggtgagatg gatcctccta gaatacaagt 60 t 61 <210> SEQ ID NO 1845 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1845 gctgagagct ctctcttctc tgttacaaaa ygagataagc aagtgttaga attgccttaa 60 g 61 <210> SEQ ID NO 1846 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1846 cccactattt ttaaggaaga aatcattttg sttgaaggca tcactcttgg ttgtgatcag 60 a 61 <210> SEQ ID NO 1847 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1847 agatcagaaa tattcggagg aagaattgtg sctgtactga acatggacag attttttctt 60 g 61 <210> SEQ ID NO 1848 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1848 tcagcatcga cagggaagac agttttttca ytgtcagccg ttctgactgg ccgggtagga 60 a 61 <210> SEQ ID NO 1849 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1849 atgatggtta tccgggtccc aagtccaaag waagctagaa aaggctgcta actgggggag 60 g 61 <210> SEQ ID NO 1850 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1850 tccctgacag cccctgaggc accgtctgaa rcagggtcgg agctggatgg atcctgggga 60 g 61 <210> SEQ ID NO 1851 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1851 tgctgcccaa ggaggcgcag atctgcgaga rgcccaacct gaacgccatc aacatcacgg 60 c 61 <210> SEQ ID NO 1852 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1852 gcacatagtg ggtatccagt acgactccgc scttcctcac tcctttgttg gggtaagtaa 60 a 61 <210> SEQ ID NO 1853 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1853 taaaaactgg ggaaagagga tgaccaacac raaatcacca tcctaaaaga gttgacagtc 60 t 61 <210> SEQ ID NO 1854 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1854 cgtcacactg agagtatctg gagaccttca ygttggagga gtgatgctca agttagtaga 60 a 61 <210> SEQ ID NO 1855 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1855 ttaaatttct attcaaatgt attttttaga rcttgattgt tgttgcccgt acatgtatac 60 g 61 <210> SEQ ID NO 1856 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1856 ctacattagg ctataacttt tctttggatc mgtgccatgt gaacactaga aaccaacaca 60 g 61 <210> SEQ ID NO 1857 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1857 tgggcaccac cagcagcaac cactctggtg rctttaattt ctggtaagtc agacttttaa 60 a 61 <210> SEQ ID NO 1858 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1858 ctaactgtat atttgtaccc accactaatc wttccatagc ttgcaagacc agctctatct 60 a 61 <210> SEQ ID NO 1859 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1859 gtaggctggg ctaagctatg gtgtttggca ygttaggtat gttaaatgta tttttgactt 60 a 61 <210> SEQ ID NO 1860 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1860 gtgatttgtt ttctgaactc ctgcagggaa saaaaaaaag gtaatattgg ccccatacaa 60 t 61 <210> SEQ ID NO 1861 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1861 accacctcga atttggaaat actttcttca yttaacagag aggttgagta aattgcctca 60 g 61 <210> SEQ ID NO 1862 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1862 tatttggatt gaagtacata tcttgaatca rattaaagtt gtacagcatg taaggctaaa 60 t 61 <210> SEQ ID NO 1863 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1863 tcaatggata caaaagtatg taatagaagg rggctgatga tcagggaggg atagaaaaat 60 t 61 <210> SEQ ID NO 1864 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1864 agagatcttt cacctacttg cttagatgta ytcctcagta ttttattatt tctgttacta 60 t 61 <210> SEQ ID NO 1865 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1865 ggctaaaatt agttcttgaa ggatgaaaaa mgtcttattc cttttctgta taaagcacag 60 a 61 <210> SEQ ID NO 1866 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1866 ccaccacaca gtctgtagct tctagcctcc sttcctttgc acgtgccttt cccaggatcc 60 g 61 <210> SEQ ID NO 1867 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1867 acaggggaga tttttgttca ctggtaacca maggtagaga gtgctgtatt cccccatgcc 60 a 61 <210> SEQ ID NO 1868 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1868 attctggctg ttagactgtg atgaagatgc mgacactcca ggattcagca gcctggggct 60 t 61 <210> SEQ ID NO 1869 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1869 tgatgcatga tttgcttact cacaatctaa katcttttct gtaacttgtc tctgggcctc 60 t 61 <210> SEQ ID NO 1870 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1870 ggatttatca tctttagaag tcagtgatgg ygcagttcat gttgcttggg ggtgtggaga 60 t 61 <210> SEQ ID NO 1871 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1871 tgatcagctt ttcataatca taggcctctt ygggctagca cttttcatac atcacacttg 60 g 61 <210> SEQ ID NO 1872 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1872 gacacctcat ccaggatgga agcgggaacc raaagcctgg ctgagagacc ccaggggcct 60 g 61 <210> SEQ ID NO 1873 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1873 aaccaaggcc acacccctag caagaggacc kgctttcacc agtaactgaa gctgtgcaga 60 g 61 <210> SEQ ID NO 1874 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1874 tattgggtga caactctgtt tcaggtacta ygctagtctc ttcccacaag gacctcacag 60 c 61 <210> SEQ ID NO 1875 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1875 acttgtacag gggtaggtag cataaaagac mgccgttctc aagaggcaac catgcgcctc 60 a 61 <210> SEQ ID NO 1876 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1876 aatacacagt gctaactagc agagtcacgc rtcggaagtg tgctgggccc ataaaataca 60 c 61 <210> SEQ ID NO 1877 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1877 aacatgggac ttacagcatg agtatcattc rgccactaaa cagtacactt cacgcatgaa 60 c 61 <210> SEQ ID NO 1878 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1878 ggacatgaga aaatgctcat gatcaaatgg yaggagaacg aaactatatt tacagtacga 60 t 61 <210> SEQ ID NO 1879 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1879 actggggctc gccatctgca aatgaggtga ygctatttac cttgcagggc ccaagagggt 60 t 61 <210> SEQ ID NO 1880 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1880 gtgcaaagtg acagacaaat gagtcatccc yggtctttcc aaggacaggg actcatctgg 60 c 61 <210> SEQ ID NO 1881 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1881 atttgagagc tatatattta aatgcagtgc yaagggtttc atttaacacg aggaaaaaac 60 c 61 <210> SEQ ID NO 1882 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1882 ggaaaagata atttgctttc tctctcaagt yccacttatg tgtttgtaga ttagatttgg 60 c 61 <210> SEQ ID NO 1883 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1883 ctgtctccta agaactagga cactcaaata ygcaactgtg attacatgga aataaaaaca 60 c 61 <210> SEQ ID NO 1884 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1884 aggcgtaact aatctacacc cttcgaagcc rggacaggga agagaaagag gaggcaggca 60 g 61 <210> SEQ ID NO 1885 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1885 cagtgaccac cgttaggtga gcaaggcagt waaattacag agcaaaatct aacaggccag 60 a 61 <210> SEQ ID NO 1886 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1886 aggcaatctg gttgcagagc tccttactaa yaacagctca ctgcaggcac ttgtagcccc 60 a 61 <210> SEQ ID NO 1887 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1887 gcagcgcctg gcagagccag tgcagtcaga sgagccctga agtgtgggca caaaaacctg 60 c 61 <210> SEQ ID NO 1888 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1888 attgaaacca agttagttac agacatagat sccgtcttaa gcaaaggaca cacataatct 60 c 61 <210> SEQ ID NO 1889 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1889 taggaaactt cagaatacac agttgatcct mtctaaagac caccctgcag gtccaggcag 60 a 61 <210> SEQ ID NO 1890 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1890 ctctgaagtc aggaaactca tttaaacagg rtctgtaccg aaattcagga aggtcaagga 60 g 61 <210> SEQ ID NO 1891 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1891 tgagcagcgc cctttctgca gaaagtaaag mgcaccttgc cgagagatca tttgtttctg 60 t 61 <210> SEQ ID NO 1892 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1892 ccagtgagac gcagaaacgg atcctttgtc ygacttcctc cagattgcct ggggttggac 60 c 61 <210> SEQ ID NO 1893 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1893 acgtcacact ttgccaggaa actcgccttc raccaagaag gtccccagca aagtaactca 60 t 61 <210> SEQ ID NO 1894 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 1894 gatttatacc aatcttgcac atattttact ycgaatttca caaactcaat tctctgcttt 60 c 61

Claims

1. A method of determining a likelihood or risk of severity of a schizophrenia (SZ) endophenotype in a human subject, the method comprising: determining the identity of an allele at rs7897566 in a sample comprising genomic DNA of a subject having or suspected of having SZ; wherein the presence of a C allele at rs7897566 indicates that the subject is more likely to have a higher PANSS Total composite score, a higher PANSS Positive composite score, a higher PANSS General Psychopathology composite score, a higher PANSS Negative composite score, a higher N4 score, a higher N6 score, a higher N7 score, a higher G14 score, a higher G15 score, a higher G7 score, a higher G13 score, a higher G16 score, a higher G11 score, or a higher P2 score, as compared to a subject who does not have a C allele at rs7897566.

2. The method of claim 1, further comprising obtaining the sample from the subject.

3. The method of claim 1, wherein determining the identity of an allele at rs7897566 comprises: contacting the sample with a probe specific for a selected allele at rs7897566; and detecting the formation of complexes between the probe and the selected allele, wherein the formation of complexes between the probe and the selected allele indicates the presence of the selected allele in the sample.

4. The method of claim 1, wherein determining the identity of an allele at rs7897566 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1401.

5. The method of claim 1, further comprising selecting a subject who has or is suspected of having SZ.

6. The method of claim 1, wherein the subject has one or more risk factors associated with SZ.

7. The method of claim 6, wherein the risk factors associated with SZ include one or both of: a relative afflicted with a schizophrenia spectrum disorder (SSD), and a genetically-based phenotypic trait associated with risk for a SSD.

8. The method of claim 1, further comprising selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele in the subject.

9. The method of claim 1, further comprising stratifying a subject population for analysis of a clinical trial based on the identity of the allele in the subjects.

10. The method of claim 1, further comprising confirming a severity of a SZ endophenotype using a psychometric instrument.

11. The method of claim 1, further comprising recording the identity of the allele in a tangible medium.

12. The method of claim 11, wherein the tangible medium comprises a computer-readable disk, a solid state memory device, or an optical storage device.

13. A method of determining a likelihood or risk of severity of a schizophrenia (SZ) endophenotype in a human subject, the method comprising: determining the identity of an allele at rs7897566 in the potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (KCNMA1) gene in a sample comprising genomic DNA of a subject having or suspected of having SZ; and determining the identity of one or more allele(s) at rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, and rs2719986 in the KCNMA1 gene in the sample; wherein the presence of a C allele at rs7897566 indicates that the subject is more likely to have a higher PANSS Total composite score, a higher PANSS Positive composite score, a higher PANSS General Psychopathology composite score, a higher PANSS Negative composite score, a higher N4 score, a higher N6 score, a higher N7 score, a higher G14 score, a higher G15 score, a higher G7 score, a higher G13 score, a higher G16 score, a higher G11 score, or a higher P2 score, as compared to a subject who does not have a C allele at rs7897566; the presence of a G allele at rs2288840 indicates that the subject is more likely to have a higher P7 score, as compared to a subject who does not have a G allele at rs2288840; the presence of a C allele at rs7067873 indicates that the subject is more likely to have a higher P4 score, as compared to a subject who does not have a C allele at rs7067873; the presence of a T allele at rs1907729 indicates that the subject is more likely to have a lower G6 score, as compared to a subject who does not have a T allele at rs1907729; the presence of an A allele at rs11002139 indicates that the subject is more likely to have a lower G12 score, as compared to a subject who does not have an A allele at rs11002139; the presence of a T allele at rs10824547 indicates that the subject is more likely to have a higher N3 score, as compared to a subject who does not have a T allele at rs10824547; and the presence of a T allele at rs2719986 indicates that the subject is more likely to have a lower P6 score, as compared to a subject who does not have a T allele at rs2719986.

14. The method of claim 13, wherein the identity of the alleles at rs7897566, rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, and rs2719986 in the KCNMA1 gene in the sample are determined.

15. The method of claim 13, further comprising obtaining the sample from the subject.

16. The method of claim 13, wherein determining the identity of an allele at rs7897566 or determining the identity of an allele at rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, or rs2719986 comprises: contacting the sample with a probe specific for a selected allele at rs7897566, rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, or rs2719986; and detecting the formation of complexes between the probe and the selected allele, wherein the formation of complexes between the probe and the selected allele indicates the presence of the selected allele in the sample.

17. The method of claim 13, wherein determining the identity of an allele at rs7897566 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1401; determining the identity of an allele at rs2288840 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1396; determining the identity of an allele at rs7067873 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1399, determining the identity of an allele at rs1907729 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1400, determining the identity of an allele at rs11002139 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1404, determining the identity of an allele at rs10824547 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1406, or determining the identity of an allele at rs2719986 comprises determining the identity of the nucleotide at position 31 of SEQ ID NO: 1407.

18. The method of claim 13, further comprising selecting a subject who has or is suspected of having SZ.

19. The method of claim 13, wherein the subject has one or more risk factors associated with SZ.

20. The method of claim 19, wherein the risk factors associated with SZ include one or both of: a relative afflicted with a schizophrenia spectrum disorder (SSD), and a genetically-based phenotypic trait associated with risk for a SSD.

21. The method of claim 13, further comprising selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele at rs7897566 and the identity of one or more allele(s) at rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, and rs2719986 in the subject.

22. The method of claim 13, further comprising stratifying a subject population for analysis of a clinical trial based on the identity of the allele at rs7897566 and the identity of one or more allele(s) at rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, and rs2719986 in the subjects.

23. The method of claim 13, further comprising confirming a severity of a SZ endophenotype using a psychometric instrument.

24. The method of claim 13, further comprising recording the identity of the allele at rs7897566, and the identity of one or more allele(s) at rs2288840, rs7067873, rs1907729, rs11002139, rs10824547, and rs2719986 in a tangible medium.

25. The method of claim 24, wherein the tangible medium comprises a computer-readable disk, a solid state memory device, or an optical storage device.

Images