Patent application number | Description | Published |
20140234287 | SUMOYLATION OF SERCA2a AND CARDIOVASCULAR DISEASE - Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation. | 08-21-2014 |
20150218148 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators - Provided are SUMO activators, which can enhance SUMOylation of SERCA2a, which are useful in the treatment of heart failure, cardiovascular diseases, cancer, neurodegenerative disorders, viral infection, bacterial infection, liver disease, inflammation, and other diseases. | 08-06-2015 |
20150316551 | Sumoylation of SERCA2a and Cardiovascular Disease - Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation. | 11-05-2015 |
Patent application number | Description | Published |
20160092972 | Operation Management - Described herein are systems, methods, and apparatus for managing operations, for instance making orders and fulfilling orders, using one or more computing devices. In accordance with an example embodiment, an operations management system can include a self-order system, a self-payment system, and an order-fulfillment system. The self-order system, the self-payment system, and the order-fulfillment system can communicate with each other via a communication system that connects the systems, such as a wireless network for example. Using the operation management system, orders can be placed and fulfilled efficiently and with minimal personal interaction. | 03-31-2016 |
20160093003 | OPERATION MANAGEMENT - Described herein are systems, methods, and apparatus for managing operations, for instance making orders and fulfilling orders, using one or more computing devices. In accordance with an example embodiment, an operations management system can include a self-order system, a self-payment system, and an order-fulfillment system. The self-order system, the self-payment system, and the order-fulfillment system can communicate with each other via a communication system that connects the systems, such as a wireless network for example. Using the operation management system, orders can be placed and fulfilled efficiently and with minimal personal interaction. | 03-31-2016 |
Patent application number | Description | Published |
20140257192 | SYSTEMS AND METHODS FOR ADMINISTERING MEDICATION - The syringe systems disclosed herein provide in part devices for allowing patients with compromised joint strength to more easily administer medicine. Certain exemplary syringe embodiments include a handle forming a handgrip, a syringe barrel that magnifies the dosage marks located on an inner barrel, and a tip cap slidably engageable with the syringe barrel for shielding a needle. | 09-11-2014 |
20150096644 | OIL POURER WITH MOVABLE FUNNEL SECTION - An oil pourer includes a spout shell that is configured to be connected with a bottle of culinary oil and a collapsible funnel section connected with the spout shell and moveable with respect to the spout shell between an open position and a closed position. When the funnel section is in the open position, the funnel section and the spout shell define an oil-filling opening. When the funnel section is in the closed position, the funnel section seals against the spout shell to close the oil-filling opening. A method of using an oil pourer is also disclosed. | 04-09-2015 |
20150132458 | HOT BEVERAGE MAKER - A hot beverage maker includes a pump, a kettle, a pumped fluid conduit, and a brew basket assembly. The kettle includes a reservoir, a heating element in the kettle for heating water in the reservoir, a spout for pouring water from the reservoir, and a pump inlet opening for providing heated water from the reservoir to the pump inlet. The pumped fluid conduit is connected with the pump outlet and includes a pumped fluid outlet. The brew basket assembly includes a pumped fluid outlet receptacle and a brew basket. The reservoir is selectively fluidly connectable with the brew basket via the pump inlet opening in the kettle being selectively fluidly connected with the pump inlet or the pumped fluid conduit outlet being selectively fluidly connectable with the pumped fluid outlet receptacle to selectively provide heated water from the reservoir to the brew basket. | 05-14-2015 |
20150141931 | SYSTEMS FOR AUTOMATICALLY ADMINISTERING MEDICATION - The autoinjector systems disclosed herein provide in part devices for allowing patients with reduced joint strength to more easily administer medicine. Certain exemplary syringe embodiments include a housing, a syringe assembly slidably mounted on the housing, and a needle cap releasably engaged to the housing, where the cap includes a protruding pocket for receiving a needle cap remover. | 05-21-2015 |
Patent application number | Description | Published |
20120207426 | FLIP-CHIP PACKAGING FOR DENSE HYBRID INTEGRATION OF ELECTRICAL AND PHOTONIC INTEGRATED CIRCUITS - A chip system and method includes a photonics chip and an electrical integrated circuit (IC) flip-chip coupled to the photonics chip to form an optochip. The IC or the photonics chip includes an array of bond pads for attachment to the other. The optochip has an array of bond pads for subsequent attachment to a carrier where the photonics chip includes an exposed edge to connect with at least one waveguide. | 08-16-2012 |
20130084039 | LENS ARRAY OPTICAL COUPLING TO PHOTONIC CHIP - A photonic integrated circuit apparatus is disclosed. The apparatus includes a photonic chip and a lens array coupling element. The photonic chip includes a waveguide at a side edge surface of the photonic chip. The lens array coupling element is mounted on a top surface of the photonic chip and on the side edge surface. The coupling element includes a lens array that is configured to modify spot sizes of light traversing to or from the waveguide. The coupling element further includes an overhang on a side of the coupling element that opposes the lens array and that abuts the top surface of the photonic chip. The overhang includes a vertical stop surface that has a depth configured to horizontally align an edge of the waveguide with a focal length of the lens array and that vertically aligns focal points of the lens array with the edge of the waveguide. | 04-04-2013 |
20130181233 | SILICON PHOTONICS WAFER USING STANDARD SILICON-ON-INSULATOR PROCESSES THROUGH SUBSTRATE REMOVAL OR TRANSFER - Processing for a silicon photonics wafer is provided. A silicon photonics wafer that includes an active silicon photonics layer, a thin buried oxide layer, and a silicon substrate is received. The thin buried oxide layer is located between the active silicon photonics layer and the silicon substrate. An electrical CMOS wafer that includes an active electrical layer is also received. The active silicon photonics layer of the silicon photonics wafer is flip chip bonded to the active electrical layer of the electrical CMOS wafer. The silicon substrate is removed exposing a backside surface of the thin buried oxide layer. A low-optical refractive index backing wafer is added to the exposed backside surface of the thin buried oxide layer. The low-optical refractive index backing wafer is a glass substrate or silicon substrate wafer. The silicon substrate wafer includes a thick oxide layer that is attached to the thin buried oxide layer. | 07-18-2013 |
20130209026 | THROUGH-SUBSTRATE OPTICAL COUPLING TO PHOTONICS CHIPS - An optoelectronic integrated circuit for coupling light to or from an optical waveguide formed in an optical device layer in a near-normal angle to that layer. In an embodiment, the integrated circuit comprises a semiconductor body including a metal-dielectric stack, an optical device layer, a buried oxide layer and a semiconductor substrate arranged in series between first and second opposite sides of the semiconductor body. At least one optical waveguide is formed in the optical device layer for guiding light in a defined plane in that device layer. Diffractive coupling elements are disposed in the optical device layer to couple light from the waveguide toward the second surface of the semiconductor body at a near-normal angle to the defined plane in the optical device layer. In an embodiment, an optical fiber is positioned against the semiconductor body for receiving the light from the coupling elements. | 08-15-2013 |
20140050436 | PHOTONIC MODULATOR WITH FORWARD-AND REVERSE-BIASED DIODES FOR SEPARATE TUNING AND MODULATING ELEMENTS - A method and structure for a modulator which includes a forward-biased diode optimized for power and area to perform a tuning function, and a reverse-biased diode optimized for speed to perform a modulation function. | 02-20-2014 |
20140068534 | Designing Photonic Switching Systems Utilizing Equalized Drivers - Designing a photonics switching system is provided. A photonic switch diode is designed to attain each performance metric in a plurality of performance metrics associated with a photonic switching system based on a weighted value corresponding to each of the plurality of performance metrics. A switch driver circuit is selected from a plurality of switch driver circuits for the photonic switching system. It is determined whether each performance metric associated with the photonic switching system meets or exceeds a threshold value corresponding to each of the plurality of performance metrics based on the photonic switch diode designed and the switch driver circuit selected. In response to determining that each performance metric associated with the photonic switching system meets or exceeds the threshold value corresponding to each of the performance metrics, the photonic switching system is designed using the photonic switch diode designed and the switch driver circuit selected. | 03-06-2014 |
20150063768 | OPTICAL WAVEGUIDE STRUCTURE WITH WAVEGUIDE COUPLER TO FACILITATE OFF-CHIP COUPLING - Aspects of the invention are directed to a method for forming an optical waveguide structure. Initially, a base film stack is received with an optical waveguide feature covered by a lower dielectric layer. An etch stop feature is then formed on the lower dielectric layer, and an upper dielectric layer is formed over the etch stop feature. Subsequently, a trench is patterned in the upper dielectric layer and the etch stop feature at least in part by utilizing the etch stop feature as an etch stop. Lastly, a waveguide coupler feature is formed in the trench, at least a portion of the waveguide coupler feature having a refractive index higher than the lower dielectric layer and the upper dielectric layer. The waveguide coupler feature is positioned over at least a portion of the optical waveguide feature but is separated from the optical waveguide feature by a portion of the lower dielectric layer. | 03-05-2015 |
20150302124 | Designing Photonic Switching Systems Utilizing Equalized Drivers - Designing a photonics switching system is provided. A photonic switch diode is designed to attain each performance metric in a plurality of performance metrics associated with a photonic switching system based on a weighted value corresponding to each of the plurality of performance metrics. A switch driver circuit is selected from a plurality of switch driver circuits for the photonic switching system. It is determined whether each performance metric associated with the photonic switching system meets or exceeds a threshold value corresponding to each of the plurality of performance metrics based on the designed photonic switch diode and the selected switch driver circuit. In response to determining that each performance metric associated with the photonic switching system meets or exceeds the threshold value corresponding to each of the performance metrics, the photonic switching system is designed using the designed photonic switch diode and the selected switch driver circuit. | 10-22-2015 |
20150346431 | OPTICAL WAVEGUIDE STRUCTURE WITH WAVEGUIDE COUPLER TO FACILITATE OFF-CHIP COUPLING - Aspects of the invention are directed to a method for forming an optical waveguide structure. Initially, a base film stack is received with an optical waveguide feature covered by a lower dielectric layer. An etch stop feature is then formed on the lower dielectric layer, and an upper dielectric layer is formed over the etch stop feature. Subsequently, a trench is patterned in the upper dielectric layer and the etch stop feature at least in part by utilizing the etch stop feature as an etch stop. Lastly, a waveguide coupler feature is formed in the trench, at least a portion of the waveguide coupler feature having a refractive index higher than the lower dielectric layer and the upper dielectric layer. The waveguide coupler feature is positioned over at least a portion of the optical waveguide feature but is separated from the optical waveguide feature by a portion of the lower dielectric layer. | 12-03-2015 |
Patent application number | Description | Published |
20110252299 | Synthetic Navigation Elements for Electronic Documents - A computer-implemented method for managing the display of items in a web-based document application includes providing an electronic document that includes a plurality of content items, anchoring a plurality of base layers to different discrete positions of the electronic document, and anchoring ones of the plurality of content items to particular ones of the base layers so that when the spreadsheet is scrolled on a computer display, the content items move with the spreadsheet by virtue of the anchoring of the content items to the base layers and the anchoring of the base layers to the spreadsheet. | 10-13-2011 |
20110252335 | Zooming in a Web Browser - A computer-implemented method for managing the display of information in a web browser involves identifying a web browser type of a web browser on a computing device, identifying a zoom level of the web browser, obtaining size-related information about one or more graphical elements displayed by the web browser, determining a matching size for an element to be provided on the browser, and adjusting the matching size to account for zooming-related measurement errors for the identified browser type and the identified zoom level. | 10-13-2011 |
20110307772 | Scrolling in Large Hosted Data Set - A computer-implemented method of presenting an electronic document via a web browser includes maintaining on a computing device a client data model of the electronic document, the client data model comprising data that defines content of the electronic document and formatting of the content of the electronic document, and rendering a first sub-portion of content of the electronic document from the client data model to a document object model (DOM) for the web browser. The method also includes providing the DOM to the web browser, for the web browser to display a view of the electronic document from the DOM. | 12-15-2011 |
20120117452 | Synthetic Navigation Elements for Electronic Documents - A computer-implemented method for managing the display of items in a web-based document application includes providing an electronic document that includes a plurality of content items, anchoring a plurality of base layers to different discrete positions of the electronic document, and anchoring ones of the plurality of content items to particular ones of the base layers so that when the spreadsheet is scrolled an a computer display, the content items move with the spreadsheet by virtue of the anchoring of the content items to the base layers and the anchoring of the base layers to the spreadsheet. | 05-10-2012 |
Patent application number | Description | Published |
20100240763 | Method to Determine and Biomarker for Treatment Efficacy With Ssri, Snri, and Sari Antidepressants - The invention provides a method for determining whether a patient suffering from a condition that is susceptible to treatment with a compound that activates the brain serotonin system is resistant to treatment with the compound. The method comprises observing whether the genome of the patient contains at least one copy of the BDNF allele containing a genetic alteration, and correlating the presence of the allele containing the genetic alteration with patients who are resistant to treatment with the compound. In another embodiment, the method comprises observing whether the patient expresses a BDNF protein containing an amino acid alteration, and correlating the expression of the BDNF protein containing the amino acid alteration with patients who are resistant to treatment with the compound. | 09-23-2010 |
20110207827 | METHOD FOR DETERMINING SENSITIVITY OR RESISTANCE TO COMPOUNDS THAT ACTIVATE THE BRAIN SEROTONIN SYSTEM - The invention relates to a method for determining whether a patient suffering from a condition that is susceptible to treatment with a compound that activates the brain serotonin system is susceptible or resistant to treatment with the compound. The method includes establishing whether the patient is a pre-adult, a transition age patient, or an adult and observing whether the genome of the patient contains at least one copy of a BDNF allele having a genetic alteration. The method further includes correlating the presence of the allele containing the genetic alteration with susceptibility or resistance of the patient to the treatment with the compound, wherein a pre-adult patient containing the genetic alteration is correlated as being susceptible to the treatment; a transition age patient containing the genetic alteration is correlated as being susceptible or resistant to the treatment; and an adult patient containing the genetic alteration is correlated as being resistant to the treatment. | 08-25-2011 |
20120322068 | METHOD FOR IDENTIFYING INCREASED RISK OF ANXIETY DISORDERS - The present invention is for methods for identifying a human having an increased risk for anxiety disorders. The method involves genotyping the human for a specific brain-derived neurotrophic factor (BDNF) single nucleotide polymorphism (SNP), and/or administering a fear conditioning procedure while measuring fear, and administering an extinction procedure while measuring fear. The method can also involve comparing/MRI images of the amygdala of the human acquired during conditioning and extinction and determining if the human is unresponsive to extinction therapy by noting heightened and non-declining activity in the amygdala during extinction. | 12-20-2012 |
Patent application number | Description | Published |
20140235933 | GENETIC MODIFICATION OF RATS - Compositions and methods are provided for making rat pluripotent and totipotent cells, including rat embryonic stem (ES) cells. Compositions and methods for improving efficiency or frequency of germline transmission of genetic modifications in rats are provided. Such methods and compositions comprise an in vitro culture comprising a feeder cell layer and a population of rat ES cells or a rat ES cell line, wherein the in vitro culture conditions maintain pluripotency of the ES cell and comprises a media having mouse leukemia inhibitor factor (LIF) or an active variant or fragment thereof. Various methods of establishing such rat ES cell lines are further provided. Methods of selecting genetically modified rat ES cells are also provided, along with various methods to generate a transgenic rat from the genetically modified rat ES cells provided herein. Various kits and articles of manufacture are further provided. | 08-21-2014 |
20140309487 | TARGETED MODIFICATION OF RAT GENOME - Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. | 10-16-2014 |
20140310828 | TARGETED MODIFICATION OF RAT GENOME - Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. | 10-16-2014 |
20150159174 | Methods and Compositions for the Targeted Modification of a Genome - Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided. | 06-11-2015 |
20150159175 | METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME - Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided. | 06-11-2015 |
20160060657 | METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME - Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided. | 03-03-2016 |
Patent application number | Description | Published |
20110047621 | SYSTEM AND METHOD FOR DETECTION OF NON-COMPLIANT SOFTWARE INSTALLATION - A system and method for performing a security check may include using at least one processor to periodically check a status of a flag, generate and store a baseline representation of modules stored on the device where the flag is determined to be set to a first state, and, where the flag is determined to be set to a second state, generate an active representation of modules stored on the first device, compare the active representation of modules to the baseline representation of modules, and, responsive to a determination in the comparing step of a difference between the baseline and active representations of modules, output an alert. The flag status may depend on an association of the device with one of a plurality of authorization policies, each mapped to one of the two states. Results of the comparison may be appended to an activity log of the device. | 02-24-2011 |
20130247196 | SYSTEM AND METHOD FOR DETECTION OF NON-COMPLIANT SOFTWARE INSTALLATION - A system and method for performing a security check may include using at least one processor to periodically check a status of a flag, generate and store a baseline representation of modules stored on the device where the flag is determined to be set to a first state, and, where the flag is determined to be set to a second state, generate an active representation of modules stored on the first device, compare the active representation of modules to the baseline representation of modules, and, responsive to a determination in the comparing step of a difference between the baseline and active representations of modules, output an alert. The flag status may depend on an association of the device with one of a plurality of authorization policies, each mapped to one of the two states. Results of the comparison may be appended to an activity log of the device. | 09-19-2013 |
Patent application number | Description | Published |
20080294102 | Balloon Cannulae - A vascular catheter with a circular external diameter, a circular lumen contained within, and an inflatable balloon that overlies a trough in the catheter body such that when the balloon is deflated, the balloon does not protrude beyond the outer circumference of the catheter shaft. The wall of the catheter shaft is thicker along one side than along the remainder of the circumference of the catheter shaft to permit an inflation lumen to be disposed within the thick wall section without increasing the outer diameter of the remaining portion of the circumference. The inflatable balloon is further disposed to maintain the circular lumen of the catheter in the center of flow of the blood vessel in which it is used, maintaining optimal flow. The combination of the circular lumen, circular outer diameter, and recessed balloon trough produces improved hemodynamic flow characteristics within the cannula over existing balloon cannula designs, minimizing flow-related injuries that might cause embolization or vascular dissection. | 11-27-2008 |
20090125102 | IMPLANTABLE DEVICES FOR CONTROLLING THE INTERNAL CIRCUMFERENCE OF AN ANATOMIC ORIFICE OR LUMEN - An implantable device for controlling the circumference of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implants are disclosed which employ various means for adjusting and maintaining the size of an orifice to which they are attached. Systems permit the implants to be implanted using minimally invasive procedures and permit final adjustments to the circumference of the implants after the resumption of normal flow of anatomic fluids in situ. Methods are disclosed for using the implants to treat heart valve abnormalities, gastroesophageal abnormalities, anal incontinence, and the like. | 05-14-2009 |
20090234404 | Methods and devices for modulation of heart valve function - Methods and devices for modulating heart valve function are provided. In the subject methods, a heart valve is first in structurally modified. Blood flow through the structurally modified heart valve is then monitored, and the heart is paced in response to the monitored blood flow. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods find use in a variety of applications. | 09-17-2009 |
20110009956 | MAGNETIC DOCKING SYSTEM AND METHOD FOR THE LONG TERM ADJUSTMENT OF AN IMPLANTABLE DEVICE - An implantable device for controlling the circumference of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implants are disclosed which employ various means for adjusting and maintaining the size of an orifice to which they are attached. Systems permit the implants to be implanted using minimally invasive procedures and permit final adjustments to the circumference of the implants after the resumption of normal flow of anatomic fluids in situ. The invention may include an adjustment tool for making the final adjustments to the circumference that locks onto the adjustment means of the device with magnets. Methods are disclosed for using the implants to treat heart valve abnormalities, gastroesophageal abnormalities, anal incontinence, and the like. | 01-13-2011 |
20110208295 | IMPLANTABLE DEVICES FOR CONTROLLING THE SIZE AND SHAPE OF AN ANATOMICAL STRUCTURE OR LUMEN - An implantable device system for controlling the dimensions of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implantable devices are disclosed which employ various mechanisms for adjusting and maintaining the size of an orifice to which they are attached. Systems permit the implants to be implanted using minimally invasive procedures and permit final adjustments to the dimensions of the implants after the resumption of normal flow of anatomic fluids in situ. | 08-25-2011 |
20110257633 | MAGNETIC DOCKING SYSTEM AND METHOD FOR THE LONG TERM ADJUSTMENT OF AN IMPLANTABLE DEVICE - An implantable device for controlling the circumference of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implants are disclosed which employ various means for adjusting and maintaining the size of an orifice to which they are attached. Systems permit the implants to be implanted using minimally invasive procedures and permit final adjustments to the circumference of the implants after the resumption of normal flow of anatomic fluids in situ. The invention may include an adjustment tool for making the final adjustments to the circumference that locks onto the adjustment means of the device with magnets. Methods are disclosed for using the implants to treat heart valve abnormalities, gastroesophageal abnormalities, anal incontinence, and the like. | 10-20-2011 |
20130345802 | IMPLANTABLE DEVICES FOR CONTROLLING THE SIZE AND SHAPE OF AN ANATOMICAL STRUCTURE OR LUMEN - An implantable device system for controlling the dimensions of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implantable devices are disclosed which employ various mechanisms for adjusting and maintaining the size of an orifice to which they are attached. Systems permit he implants to be implanted using minimally invasive procedures and permit final adjustments to the dimensions of the implants after the resumption of normal flow of anatomic fluids in situ. | 12-26-2013 |
20140018913 | METHODS FOR CONTROLLING THE INTERNAL CIRCUMFERENCE OF AN ANATOMIC ORIFICE OR LUMEN - A method for controlling the circumference of internal anatomic passages corrects physiologic dysfunctions resulting from a structural orifice or lumen which is either too large or too small. Implants are disclosed which employ various means for adjusting and maintaining the size of an orifice to which they are attached. Systems permit the implants to be implanted using minimally invasive procedures and permit final adjustments to the circumference of the implants after the resumption of normal flow of anatomic fluids in situ. Methods are disclosed for using the implants to treat heart valve abnormalities, gastroesophageal abnormalities, anal incontinence, and the like. | 01-16-2014 |
20140018916 | METHODS AND DEVICES FOR MODULATION OF HEART VALVE FUNCTION - Methods and devices for modulating heart valve function are provided. In the subject methods, a heart valve is first in structurally modified. Blood flow through the structurally modified heart valve is then monitored, and the heart is paced in response to the monitored blood flow. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods find use in a variety of applications. | 01-16-2014 |
20140031929 | IMPLANTABLE DEVICES FOR CONTROLLING THE INTERNAL CIRCUMFERENCE OF AN ANATOMIC ORIFICE OR LUMEN - An implantable device for controlling the circumference of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implants area disclosed which employ various means for adjusting and maintaining the size of an orifice to which they are attached. Systems permit the implants to be implanted using minimally invasive producers and permit final adjustments to the circumference of the implants after the resumption of normal flow of anatomic fluids in situ. Methods are disclosed for using the implants to treat heart valve abnormalities, gastroesophageal abnormalities, anal incontinence, and the like. | 01-30-2014 |
20140336756 | METHODS AND APPARATUS FOR CONTROLLING THE INTERNAL CIRCUMFERENCE OF AN ANATOMIC ORIFICE OR LUMEN - An implantable device is provided for controlling at least one of shape and size of an anatomical structure or lumen. An implantable device has an adjustable member configured to adjust the dimensions of the implantable device. An adjustment tool is configured to actuate the adjustable member and provide for adjustment before, during and after the anatomical structure or lumen resumes near normal to normal physiologic function. | 11-13-2014 |
20150018941 | METHODS AND APPARATUS FOR CONTROLLING THE INTERNAL CIRCUMFERENCE OF AN ANATOMIC ORIFICE OR LUMEN - An implantable device is provided for controlling shape and/or size of an anatomical structure or lumen. The implantable device has an adjustable member configured to adjust the dimensions of the implantable device. The implantable device is housed in a catheter and insertable from a minimally invasive surgical entry. An adjustment tool actuates the adjustable member and provide for adjustment before, during or after the anatomical structure or lumen resumes near normal to normal physiologic function. | 01-15-2015 |
Patent application number | Description | Published |
20110238762 | GEO-CODED COMMENTS IN A MESSAGING SERVICE - Some techniques feature a computer-implemented method for messages associated with a user location. The method involves determining, by a mobile computing device, an estimated geographic location of the mobile computing device. The method includes receiving, at the mobile computing device, one or more messages associated with an area within the estimated geographic location, where the one or more messages include messages posted by users of a system that associates messages that those users posted about the area within the estimated geographic location. The method involves providing, on a display of the mobile computing device, one or more posted message icons that are presented in a layer over a map, where the one or more posted message icons represent the one or more posted messages. In a system, the one or more posted messages may not appear on mobile devices after a predetermined amount of time from their respective postings. | 09-29-2011 |
20150195330 | PERMISSION-BASED SNAPSHOTS FOR DOCUMENTS SHARED ON A SOCIAL MEDIA SERVICE - A method of storing a preview image of a document shared over a social media service includes receiving at a server a first notification that a document stored on the server is being shared on a post by a first user on the social media service, where the first notification includes information identifying the first user. The method further includes generating a thumbnail image from the document, where the thumbnail image is stored in the document metadata and is a representative image of a first version of the document at the time the user shares the document, associating the thumbnail image with a URL, where the URL has an access control list that includes the first user, and sending the URL from the server to the social media service. | 07-09-2015 |
Patent application number | Description | Published |
20080205355 | Optimal path routing method in wireless network - An optimal path routing method is provided for transmitting data from a source node to a destination node. The optimal path setting method includes transmitting a shortcut request (SCRQ) message from the source node to a topology server; determining shortcut information at the topology server based on the SCRQ message; and transmitting a shortcut notification (SCNF) message containing the shortcut information from the topology server to the destination node. | 08-28-2008 |
20100034159 | SENSOR NETWORK MEDIUM ACCESS CONTROL (MAC) SYSTEM FOR MULTIHOP COMMUNICATION - A medium access control (MAC) technique of a multihop sensor network. In the multihop sensor network, the MAC technique may contribute to significantly reducing transmission delay, and allow real-time services to be provided to all nodes by extending a guaranteed time slot (GTS) restricted to one hop in a personal area network (PAN) coordinator (PNC) to all nodes. Furthermore, the MAC technique may allow the number of available GTSs to be significantly increased, by using all 16 frequency band channels instead of using only a single frequency band and setting a multi-superframe. | 02-11-2010 |
20100278156 | DATA COMMUNICATION METHOD USING BODY AREA NETWORK SUPERFRAME - There is provided a data communication method using a body area network superframe including an advertisement period, a contention medium access period, a beacon period, and a data transmit period, the data communication method including: broadcasting, by a coordinator node, predetermined information during the advertisement period; transmitting, by nodes, which wish to transmit data, the data only when carrier is not in use as a result of sensing the carrier after the contention medium access period is initiated and a predetermined backoff time elapses; broadcasting, by each of the nodes, periodic beacon signals during the beacon period; and transmitting, by each of the nodes, continuous data and periodic data during the data transmit period | 11-04-2010 |
20100284334 | ASYNCHRONOUS MULTI-CHANNEL ADAPTATION METHOD FOR WIRELESS AD-HOC NETWORK - There is provided an asynchronous multi-channel adaptation method. An asynchronous multi-channel adaptation method according to an aspect of the invention may include: a channel scanning operation in which a new node, participating in a wireless ad-hoc network, scans channels and selects a receiving channel thereof; and a receiving channel information transmission operation in which the new node transmits information on the selected receiving channel thereof to a neighboring node. | 11-11-2010 |
Patent application number | Description | Published |
20090025186 | EYEGLASS AND OTHER PERSONAL ITEMS HOLDER - A holder for securing eyeglasses, sunglasses or other personal items that may be securely incorporated into an article of clothing at the time the article is manufactured. The holder includes a base member that can be inserted into an article of clothing. The base member can be securely attached to an interconnecting cord. The cord may have one end threaded through the article of clothing and securely affixed to the base member and the other end securely affixed to the external part of the holder. The external part of the holder can include a hanger with a support base and a loop. The holder allows a wearer to insert a temple piece of a pair of eyeglasses, or a hook attached to another personal item, through the loop and allows the item to assume a secure and relatively flat position against the wearer's body. The holder may also in include an RFID tag. The holder may also include a covered loop. The covering may be either internal or external. The covering may include a design, logo or monogram. | 01-29-2009 |
20130098957 | EYEGLASS AND OTHER PERSONAL ITEMS HOLDER - A holder for securing eyeglasses, sunglasses or other personal items that may be securely incorporated into an article of clothing or accessory at the time of manufacture. The holder includes a base member that can be inserted into or attached to the article of clothing or accessory. A hanger is connected to the base member and includes a loop connected to a support base. One or more openings can be provided on the base member. The support base and base member can be integrally formed. The support base can be formed from part of the article of clothing or accessory. The holder allows a wearer to insert a piece of a pair of eyeglasses, or a part of another personal item, through the loop and allows the item to assume a secure and relatively flat position. The holder may also include an RFID tag and/or a covered loop. | 04-25-2013 |
20130276212 | EYEGLASS AND OTHER PERSONAL ITEMS HOLDER - A holder for securing eyeglasses, sunglasses or other personal items that may be securely incorporated into an article of clothing or accessory at the time of manufacture. The holder includes a base member that can be inserted into or attached to the article of clothing or accessory. A hanger is connected to the base member and includes a loop connected to a support base. One or more openings can be provided on the base member. The support base and base member can be integrally formed. The support base can be formed from part of the article of clothing or accessory. The holder allows a wearer to insert a piece of a pair of eyeglasses, or a part of another personal item, through the loop and allows the item to assume a secure and relatively flat position. The holder may also include an RFID tag and/or a covered loop. | 10-24-2013 |
Patent application number | Description | Published |
20080249959 | SYSTEMS AND METHODS FOR TRADING A TRADE LIST IN FINANCIAL MARKETS - Systems and methods are provided for maintaining neutrality while trading a list of securities using an algorithmic trading facility coupled with at least one destination. This destination includes at least one alternative trading system (ATS). This facility is coupled, via an electronic data network, to a plurality of trading clients, and configured to receive a trade request to trade a list of securities from a trading client. This request includes user defined trading constraints that are used to generate and transmit trade orders to at least one ATS. The orders are transmitted based on trading data related to the destinations, the trade list, and the trading constraints. The facility can identify each executed trade corresponding to the trade orders and calculate a trade imbalance. The facility can determine whether the trade imbalance exceeds the trading constraints, and reallocate one or more of said submitted orders based on this determination. | 10-09-2008 |
20120089503 | SYSTEMS AND METHODS FOR TRADING A TRADE LIST IN FINANCIAL MARKETS - Systems and methods are provided for maintaining neutrality while trading a list of securities using an algorithmic trading facility coupled with at least one destination. This destination includes at least one alternative trading system (ATS). This facility is coupled, via an electronic data network, to a plurality of trading clients, and configured to receive a trade request to trade a list of securities from a trading client. This request includes user defined trading constraints that are used to generate and transmit trade orders to at least one ATS. The orders are transmitted based on trading data related to the destinations, the trade list, and the trading constraints. The facility can identify each executed trade corresponding to the trade orders and calculate a trade imbalance. The facility can determine whether the trade imbalance exceeds the trading constraints, and reallocate one or more of said submitted orders based on this determination. | 04-12-2012 |
20130060677 | SYSTEMS AND METHODS FOR TRADING A TRADE LIST IN FINANCIAL MARKETS - Systems and methods are provided for maintaining neutrality while trading a list of securities using an algorithmic trading facility coupled with at least one destination. This destination includes at least one alternative trading system (ATS). This facility is coupled, via an electronic data network, to a plurality of trading clients, and configured to receive a trade request to trade a list of securities from a trading client. This request includes user defined trading constraints that are used to generate and transmit trade orders to at least one ATS. The orders are transmitted based on trading data related to the destinations, the trade list, and the trading constraints. The facility can identify each executed trade corresponding to the trade orders and calculate a trade imbalance. The facility can determine whether the trade imbalance exceeds the trading constraints, and reallocate one or more of said submitted orders based on this determination. | 03-07-2013 |
20150052037 | SYSTEMS AND METHODS FOR TRADING A TRADE LIST IN FINANCIAL MARKETS - Systems and methods are provided for maintaining neutrality while trading a list of securities using an algorithmic trading facility coupled with at least one destination. This destination includes at least one alternative trading system (ATS). This facility is coupled, via an electronic data network, to a plurality of trading clients, and configured to receive a trade request to trade a list of securities from a trading client. This request includes user defined trading constraints that are used to generate and transmit trade orders to at least one ATS. The orders are transmitted based on trading data related to the destinations, the trade list, and the trading constraints. The facility can identify each executed trade corresponding to the trade orders and calculate a trade imbalance. The facility can determine whether the trade imbalance exceeds the trading constraints, and reallocate one or more of said submitted orders based on this determination. | 02-19-2015 |
Patent application number | Description | Published |
20080285819 | Systems and method for composite elastography and wave imaging - Systems and methods for composite elastography and wave imaging are presented. In exemplary embodiments of the present invention an imaging modality field of view, such as, for example, that of ultrasound, can be divided into N sectors, each having 1/Nth of a full field of view. In exemplary embodiments of the present invention a temporal series of 2D or 3D ultrasound images for each of the N sectors can be acquired over a duration of one or more periods of a periodic signal. Substantially simultaneously, such a periodic signal can also be acquired, wherein each of said series of 2D ultrasound images for each sector can be triggered or gated using said periodic signal. For example, for ultrasound imaging of the heart, an ECG signal can function as such a periodic signal. The data from the various N sectors can be synchronized in time using the ECG signals, and the ultrasound signals from each of the N sectors combined to generate a series of composite ultrasound images at the frame rate of the individual sectors. In exemplary embodiments of the present invention such a composite image can be further processed to estimate displacement between consecutive frames, remove noise, accumulate displacement with time for an entire cardiac cycle, and derive strain in the cardiac muscle, vessel or any other organ or tissue under motion. In exemplary embodiments of the present invention the derived strain data can be overlaid onto all or part of the composite ultrasound images, and one or more of such overlaid images can be displayed to a user. | 11-20-2008 |
20130066211 | SYSTEMS AND METHODS FOR COMPOSITE MYOCARDIAL ELASTOGRAPHY - Systems and methods for composite myocardial elastography are presented. In exemplary embodiments of the present invention an imaging modality field of view, such as, for example, that of ultrasound, can be divided into N sectors, each having 1/Nth of a full field of view. In exemplary embodiments of the present invention a temporal series of 2D ultrasound images for each of the N sectors can be acquired over a duration of one or more periods of a periodic signal. Substantially simultaneously, such a periodic signal can also be acquired, wherein each of said series of 2D ultrasound images for each sector can be triggered using said periodic signal. For example, for ultrasound imaging of the heart, an ECG signal can function as such a periodic signal. The data from the various N sectors can be synchronized in time using the ECG signals, and the ultrasound signals from each of the N sectors combined to generate a series of composite ultrasound images at the frame rate of the individual sectors. In exemplary embodiments of the present invention such a composite image can be further processed to estimate displacement between consecutive frames, remove noise, accumulate displacement with time for an entire cardiac cycle, and derive strain in the cardiac muscle, vessel or any other organ or tissue under motion. In exemplary embodiments of the present invention the derived strain data can be overlaid onto all or part of the composite ultrasound images, and one or more of such overlaid images can be displayed to a user. | 03-14-2013 |