| Patent application number | Description | Published |
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| 20150370474 | MULTIPLE VIEW INTERFACE FOR VIDEO EDITING SYSTEM - Systems and methods for video editing and playback are provided. In one implementation, a selected portion of a timeline for navigating media content can be repositioned and resized by user input actions received along various axes relative to the timeline. In another implementation, a plurality of signals associated with media content can be intelligently weighted based on user group historical attributes to identify portions of interest in the media content. In a further implementation, an experience map for media content is provided in which a representative signature for the content includes visual signal intensity representations and social interest concentrations over the length of the content. In another implementation, a subset of filters is determined for recommendation to a user based on one or more attributes associated with at least one of media content, the user, a group of users, or a user device. | 12-24-2015 |
| 20150370806 | VISUAL EXPERIENCE MAP FOR MEDIA PRESENTATIONS - Systems and methods for video editing and playback are provided. In one implementation, a selected portion of a timeline for navigating media content can be repositioned and resized by user input actions received along various axes relative to the timeline. In another implementation, a plurality of signals associated with media content can be intelligently weighted based on user group historical attributes to identify portions of interest in the media content. In a further implementation, an experience map for media content is provided in which a representative signature for the content includes visual signal intensity representations and social interest concentrations over the length of the content. In another implementation, a subset of filters is determined for recommendation to a user based on one or more attributes associated with at least one of media content, the user, a group of users, or a user device. | 12-24-2015 |
| 20150370907 | SYSTEMS AND METHODS FOR INTELLIGENT FILTER APPLICATION - Systems and methods for video editing and playback are provided. In one implementation, a selected portion of a timeline for navigating media content can be repositioned and resized by user input actions received along various axes relative to the timeline. In another implementation, a plurality of signals associated with media content can be intelligently weighted based on user group historical attributes to identify portions of interest in the media content. In a further implementation, an experience map for media content is provided in which a representative signature for the content includes visual signal intensity representations and social interest concentrations over the length of the content. In another implementation, a subset of filters is determined for recommendation to a user based on one or more attributes associated with at least one of media content, the user, a group of users, or a user device. | 12-24-2015 |
| 20150373281 | SYSTEMS AND METHODS FOR IDENTIFYING MEDIA PORTIONS OF INTEREST - Systems and methods for video editing and playback are provided. In one implementation, a selected portion of a timeline for navigating media content can be repositioned and resized by user input actions received along various axes relative to the timeline. In another implementation, a plurality of signals associated with media content can be intelligently weighted based on user group historical attributes to identify portions of interest in the media content. In a further implementation, an experience map for media content is provided in which a representative signature for the content includes visual signal intensity representations and social interest concentrations over the length of the content. In another implementation, a subset of filters is determined for recommendation to a user based on one or more attributes associated with at least one of media content, the user, a group of users, or a user device. | 12-24-2015 |
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| 20100081705 | METHODS FOR SLOWING FAMILIAL ALS DISEASE PROGRESSION - Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS. | 04-01-2010 |
| 20120252879 | MODULATION OF HUNTINGTIN EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof. | 10-04-2012 |
| 20150159155 | MODULATION OF HUNTINGTIN EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof. | 06-11-2015 |
| 20150267197 | METHODS FOR MODULATING C9ORF72 EXPRESSION - Disclosed herein are methods for reducing expression of C90RF72 mRNA and protein in an animal with C90RF72 specific inhibitors. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Such C90RF72 specific inhibitors include antisense compounds. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration C90RF72 specific inhibitors include amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), corticalbasal degeneration syndrome (CBD), atypical Parkinsonian syndrome, and olivopontocerellar degeneration (OPCD). | 09-24-2015 |
| Patent application number | Description | Published |
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| 20100180356 | Nanoindenter - A new type of indenter is described. This device combines certain sensing and structural elements of atomic force microscopy with a module designed for the use of indentation probes, conventional diamond and otherwise, as well as unconventional designs, to produce high resolution and otherwise superior indentation measurements. | 07-15-2010 |
| 20100213930 | Integrated micro actuator and lVDT for high precision position measurements - A single housing with a non-ferromagnetic piezo-driven flexure has primary and secondary coil forms of different diameters, one coaxially inside the other, integrated in the flexure. The cylinders defining the planes of the primary and secondaries do not spatially overlap. The secondary coil forms may be wound in opposite directions and wired to provide a transformer device. Movement of the primary relative to the secondaries in the direction of the central axis of the coils can be differentially detected with high precision. | 08-26-2010 |
| 20100275334 | Modular atomic force microscope - A modular AFM/SPM which provides faster measurements, in part through the use of smaller probes, of smaller forces and movements, free of noise artifacts, that the old generations of these devices have increasingly been unable to provide. The modular AFM/SPM includes a chassis, the foundation on which the modules of the instrument are supported; a view module providing the optics for viewing the sample and the probe; a head module providing the components for the optical lever arrangement and for steering and focusing those components; a scanner module providing the XYZ translation stage that actuates the sample in those dimensions and the engage mechanism; a isolation module that encloses the chassis and provides acoustic and/or thermal isolation for the instrument and an electronics module which, together with the separate controller, provide the electronics for acquiring and processing images and controlling the other functions of the instrument. All these modules and many of their subassemblies are replaceable and potentially upgradeable. This allows updating to new technology as it becomes available. | 10-28-2010 |
| 20100333240 | Fully Digitally Controller for Cantilever-Based Instruments - A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware. | 12-30-2010 |
| 20120216322 | Digital Q control for enhanced measurement capability in cantilever-based instruments - A digital system for controlling the quality factor in a resonant device. The resonant device can be a a device that includes a cantilever within its system, such as an atomic force microscope. The quality factor can be digitally controlled to avoid noise effect in the analog components. A direct digital synthesizer implemented in a way that provides access to the output of the phase accumulator. That output is a number which usually drives a lookup table to produce a cosine or sine output wave. The output wave is created, but the number is also adjusted to form a second number that drives a second lookup table to create an adjustment factor to adjust the output from the cosine table. The adjusted digital signal than drives a DA converter which produces an output drive for the cantilever. | 08-23-2012 |
| 20120266336 | Fully Digitally Controller for Cantilever-Based Instruments - A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware. | 10-18-2012 |
| 20120272411 | Nanoindenter - A new type of indenter is described. This device combines certain sensing and structural elements of atomic force microscopy with a module designed for the use of indentation probes, conventional diamond and otherwise, as well as unconventional designs, to produce high resolution and otherwise superior indentation measurements. | 10-25-2012 |
| 20130314078 | Integrated Micro Actuator and LVDT for High Precision Position Measurements - A single housing with a non-ferromagnetic piezo-driven flexure has primary and secondary coil forms of different diameters, one coaxially inside the other, integrated in the flexure. The cylinders defining the planes of the primary and secondaries do not spatially overlap. The secondary coil forms may be wound in opposite directions and wired to provide a transformer device. Movement of the primary relative to the secondaries in the direction of the central axis of the coils can be differentially detected with high precision. | 11-28-2013 |
| 20140223612 | Modular Atomic Force Microscope - A modular AFM/SPM which provides faster measurements, in part through the use of smaller probes, of smaller forces and movements, free of noise artifacts, that the old generations of these devices have increasingly been unable to provide. The modular AFM/SPM includes a chassis, the foundation on which the modules of the instrument are supported; a view module providing the optics for viewing the sample and the probe; a head module providing the components for the optical lever arrangement and for steering and focusing those components; a scanner module providing the XYZ translation stage that actuates the sample in those dimensions and the engage mechanism; a isolation module that encloses the chassis and provides acoustic and/or thermal isolation for the instrument and an electronics module which, together with the separate controller, provide the electronics for acquiring and processing images and controlling the other functions of the instrument. All these modules and many of their subassemblies are replaceable and potentially upgradeable. This allows updating to new technology as it becomes available. | 08-07-2014 |
| 20140317790 | OPTICAL BEAM POSITIONING UNIT FOR ATOMIC FORCE MICROSCOPE - This invention relates to an optical light beam positioning system that enables the combination of two or more light beams of different wavelengths to be focused onto a probe or sample of a scientific instrument, such as an atomic force microscope, for a number of specific uses typical to AFMs, like measuring the deflection or oscillation of the probe and illuminating an object for optical imaging, and less traditional ones like photothermal excitation of the probe, photothermal activated changes in the sample, photothermal cleaning of the probe and photochemical, photovoltaic, photothermal and other light beam induced changes in the sample. The focused light beams may be independently positioned relative to each other. | 10-23-2014 |
| 20150113687 | Fully Digitally Controller for Cantilever-Based Instruments - A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware. | 04-23-2015 |
| 20150150163 | Modular atomic force microscope with environmental controls - A modular Atomic Force Microscope that allows ultra-high resolution imaging and measurements in a wide variety of environmental conditions is described. The instrument permits such imaging and measurements in environments ranging from ambient to liquid or gas or extremely high or extremely low temperatures. | 05-28-2015 |
| 20150301080 | Automated Atomic Force Microscope and the Operation Thereof - Improvements for rapidly calibrating and automatically operating a scanning probe microscope are disclosed. A central component of the SPM is the force transducer, typically a consumable cantilever element. By automatically calibrating transducer characteristics along with other instrumental parameters, scanning parameters can be rapidly and easily optimized, resulting in high-throughput, repeatable and accurate measurements. In contrast to dynamic optimization schemes, this can be accomplished before the surface is contacted, avoiding tip or sample damage from the beginning of the measurement process. | 10-22-2015 |
| 20150338438 | Modular Atomic Force Microscope with Environmental Controls - A modular Atomic Force Microscope that allows ultra-high resolution imaging and measurements in a wide variety of environmental conditions is described. The instrument permits such imaging and measurements in environments ranging from ambient to liquid or gas or extremely high or extremely low temperatures. | 11-26-2015 |
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| 20110186333 | Printed Compatible Designs and Layout Schemes for Printed Electronics - Embodiments of the present invention relate to circuit layouts that are compatible with printing electronic inks, printed circuits formed by printing an electronic ink or a combination of printing and conventional blanket deposition and photolithography, and methods of forming circuits by printing electronic inks onto structures having print-compatible shapes. The layouts include features having (i) a print-compatible shape and (ii) an orientation that is either orthogonal or parallel to the orientation of every other feature in the layout. | 08-04-2011 |
| 20130146334 | Print Compatible Designs and Layout Schemes for Printed Electronics - Embodiments of the present invention relate to circuit layouts that are compatible with printing electronic inks, printed circuits formed by printing an electronic ink or a combination of printing and conventional blanket deposition and photolithography, and methods of forming circuits by printing electronic inks onto structures having print-compatible shapes. The layouts include features having (i) a print-compatible shape and (ii) an orientation that is either orthogonal or parallel to the orientation of every other feature in the layout. | 06-13-2013 |
| 20140117298 | COMPLEMENTARY METAL OXIDE HETEROJUNCTION MEMORY DEVICES AND METHODS RELATED THERETO - A resistive memory device is disclosed. The memory device comprises one or mo re metal oxide layers. An oxygen vacancy or ion concentrations of the one or more metal oxide layer is controlled in the formation and the operation of the memory device to provide robust memory operation. | 05-01-2014 |
| 20140206138 | COMPLEMENTARY METAL OXIDE HETEROJUNCTION MEMORY DEVICES AND METHODS FOR CYCLING ROBUSTNESS AND DATA RETENTION - A memory device is disclosed. The memory device comprises a first metal layer and a first metal oxide layer coupled to the first metal layer. The first metal layer is also coupled to a second metal oxide, which in turn is couple to a second metal layer. The formation of the first metal oxide layer may occur in-situ when the first metal oxide layer has a Gibbs free energy that is lower than the Gibbs free energy for the formation of the second metal oxide layer. Control of the oxygen vacancy or ion concentrations of the first metal oxide layer and the second metal oxide layer is utilized in the information and the operation of the memory device. Selection of a dielectric constant and a thickness of the first and second metal oxide layer may be utilized to result in similar electrical field stress across the first metal oxide layer and the second metal oxide layer and improve the cycling robustness and data retention for the memory device. | 07-24-2014 |
| 20140269007 | COMPLEMENTARY METAL OXIDE OR METAL NITRIDE HETEROJUNCTION MEMORY DEVICES WITH ASYMMETRIC HYSTERESIS PROPERTY - A resistive memory device is disclosed. The resistive memory device comprises one or more metal oxide layers. The resistive memory device displays a property of asymmetric hysteresis loop formation when positive and negative electrical biases are applied across the device. | 09-18-2014 |
| 20140376299 | METHODS AND CIRCUITS FOR BULK ERASE OF RESISTIVE MEMORY - A resistive random access memory integrated circuit for use as a mass storage media and adapted for bulk erase by substantially simultaneously switching all memory cells to one of at least two possible resistive states. Bulk switching is accomplished by biasing all bottom electrodes within an erase area to a voltage lower than that of the top electrodes, wherein the erase area can comprise the entire memory array of the integrated circuit or else a partial array. Alternatively the erase area may be a single row and, upon receiving the erase command, the row address is advanced automatically and the erase step is repeated until the entire array has been erased. | 12-25-2014 |
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| 20120004216 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 01-05-2012 |
| 20120027874 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 02-02-2012 |
| 20120040020 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present disclosure relates to pyrazine compounds of formula I: | 02-16-2012 |
| 20130252333 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 09-26-2013 |
| 20140072995 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 03-13-2014 |
| 20140113005 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present disclosure relates to pyrazine compounds of formula I: | 04-24-2014 |
| 20150025076 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulator of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 01-22-2015 |
