46th week of 2012 patent applcation highlights part 40 |
Patent application number | Title | Published |
20120288798 | POSITIVE PHOTOSENSITIVE RESIN COMPOSITION, METHOD FOR PRODUCING PATTERNED CURED FILM AND ELECTRONIC COMPONENT - A positive photosensitive resin composition including: | 2012-11-15 |
20120288799 | CHARGED-PARTICLE BEAM LITHOGRAPHIC APPARATUS AND METHOD OF MANUFACTURING DEVICE - A lithographic apparatus which performs drawing on a substrate with a charged-particle beam, includes an optical system having an aperture plate in which a first number of apertures are formed to pass a first number of charged-particle beams to perform the drawing, a substrate holder, a cleaning unit configured to clean the aperture plate, and a chamber containing the optical system and the substrate holder. The cleaning unit includes a case having an emitting hole plate in which a second number of emitting holes are formed, the second number being smaller than the first number, an active species source configured to generate active species in the case, and a driving mechanism configured to move the case. | 2012-11-15 |
20120288800 | ELECTRON BEAM DRAWING APPARATUS AND METHOD OF MANUFACTURING DEVICE - An electron beam drawing apparatus performs drawing on a substrate with an electron beam emitted by an electron gun. The apparatus includes a conditioning chamber configured to perform conditioning of a spare electrode that is a spare for an electrode which constitutes the electron gun, and a driving mechanism configured to remove a used electrode from the electron gun, and to install, into the electron gun, the spare electrode having been subjected to the conditioning, wherein the conditioning includes supplying of electric power to the spare electrode. | 2012-11-15 |
20120288801 | FLEXOGRAPHIC PRINTING PLATE ASSEMBLY - A printing plate assembly for use in flexographic printing application is provided which includes an integral carrier layer, one or more cushion layers, and one or more photopolymer layers. The photopolymer layer(s) in the integral assembly are provided with relief images using digital imaging photopolymerization, which eliminates the need for a back exposure step and provides a precise relief depth for the plate. | 2012-11-15 |
20120288802 | METHOD OF FORMING GATE CONDUCTOR STRUCTURES - A method of forming gate conductor structures. A substrate having thereon a gate electrode layer is provided. A multi-layer hard mask is formed overlying the gate electrode layer. The multi-layer hard mask comprises a first hard mask, a second hard mask, and a third hard mask. A photoresist pattern is formed on the multi-layer hard mask. A first etching process is performed to etch the third hard mask, using the photoresist pattern as a first etch resist, thereby forming a patterned third hard mask. A second etching process is performed to etch the second hard mask and the first hard mask, using the patterned third hard mask as a second etch resist, thereby forming a patterned first hard mask. A third etching process is performed to etch a layer of the gate electrode layer, using the patterned first hard mask as a third etch resist. | 2012-11-15 |
20120288803 | MANUFACTURING DEVICE OF OPTICAL DEFLECTOR AND MANUFACTURING METHOD OF THE SAME - A manufacturing device of optical deflectors and a manufacturing method of the same are revealed. The manufacturing device includes a movable work platform, a substrate, a lens and a femtosecond laser source. The substrate is disposed on the movable work platform and is coated with a photoresist polymer film. The lens is arranged at one side of the movable work platform. The femtosecond laser source produces a femtosecond laser that passes through the lens and projects onto the photoresist polymer film at a non-focal position of the lens so as to produce an optical deflector. The optical deflector is produced only by the femtosecond laser projected onto the photoresist polymer film at the non-focal position. Thus the production efficiency of the optical deflector is improved. | 2012-11-15 |
20120288804 | METHOD AND DEVICE FOR OPERATING A CONVEYOR FOR A COMBUSTION PRODUCT - Method and device for operating a conveyor for a combustion product, in which, during the conveyance, through the detection and analysis of properties (such as volume flow, mass flow, moisture, temperature, grain size) of the combustion product by means of microwaves, a control of transport parameters (such as transport speed, cooling of the combustion product, supply of combustion product, degree of crushing) is realized. It is herein possible to protect the conveyor thermally and mechanically and, at the same time, to ensure real-time regulation of the composition and quantity of the combustion product for following treatment steps. | 2012-11-15 |
20120288805 | HEATING SYSTEM AND METHOD FOR OPERATING SAID SYSTEM - The invention relates to a heating system and a method for operating said system, comprising a first and a second heating device ( | 2012-11-15 |
20120288806 | Flame Sense Circuit for Gas Pilot Control - A flame sense circuit for a gas burner control employs a flame rod for flame rectification. An AC source applies an AC wave through a capacitor to the flame rod, and the flame rod is also connected via a resistive voltage divider to a DC voltage source. A voltage divider node is connected to a voltage follower, which impedance-matches an ADC input of a microprocessor controller. The flame sense circuit senses conditions of no-flame, and flame rod in contact with or leaking to ground, and when flame is present can quantify sensed flame as good, weak and marginal. | 2012-11-15 |
20120288807 | Combustor casing for combustion dynamics mitigation - A dampener or resonator is provided within a combustor casing to mitigate combustion dynamics. The combustor casing head end volume is reduced by the resonator to mitigate combustion dynamics. The resonator is formed by a ring shaped plate that carries a continuous inwardly protruding wall or segmented inwardly protruding wall portions. The resonator can be a stand alone part that is inserted into the combustor casing or it can be integrally formed with the combustor casing. | 2012-11-15 |
20120288808 | HOT AIR GENERATOR BURNER WITH INTERCHANGEABLE LIGHTER - A heat-shrink gun in which an ignition voltage of the gaseous mixture is generated by a piezoelectric lighter ( | 2012-11-15 |
20120288809 | HOT AIR GENERATOR DEVICE WITH IMPROVED LIGHTING - A hot air generating device of the type including an injection device ( | 2012-11-15 |
20120288810 | Low NOx Fuel Injection for an Indurating Furnace - An indurating furnace has a heating station and an air passage leading to the heating station. A draft of preheated recirculation air is driven through the passage toward the heating station, and is mixed with fuel gas to form a combustible mixture of preheated recirculation air and fuel gas that ignites in the passage. This is accomplished by injecting the fuel gas into the passage in a stream that does not form a combustible mixture with the preheated recirculation air before entering the passage. | 2012-11-15 |
20120288811 | ROTARY KILN END SEALING ASSEMBLY - The present invention belongs to the field of retorting apparatus used in the field of oil shale processing, in particular the invention relates to the end sealing assembly of the rotary kiln and the improvements of the end sealing ( | 2012-11-15 |
20120288812 | REGENERATIVE CHAMBER FOR A GLASS MELTING FURNACE - A regenerative chamber for a glass melting furnace having a defined cross-section and wherein the regenerative chamber includes multiple slotted arches and above the same there are disposed transfer layers, and wherein a grating is installed on the transfer layers. A movable flow barrier is provided above the slotted arches that is inserted from the outside into the regenerative chamber and by means of which the cross-section of the regenerative chamber can be reduced. | 2012-11-15 |
20120288813 | ANTI-MICROBIAL ORTHODONTIC COMPOSITIONS AND APPLIANCES AND METHODS OF PRODUCTION AND USE THEREOF - Anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions comprise an effective amount of a selenium compound. Kits containing apparatus and/or compositions are disclosed, along with methods of producing and using said anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions. | 2012-11-15 |
20120288814 | METHOD AND DEVICE FOR CAUSING TOOTH MOVEMENT - A device for increasing movement of a tooth in a jaw includes a handle, an elongate member extending from the handle, a screw tip at a distal end of the elongate member, and a sleeve. The screw tip is configured to drill into cortical bone of the jaw to increase movement of the tooth. The sleeve is configured to move along the elongate member to vary the length of exposed screw tip. | 2012-11-15 |
20120288815 | BONDABLE MOLAR TUBE - An improved bondable molar tube is provided having a base and a tube structure supported on the base, where the base is configured having a first portion that is to be bonded to a mesial cusp of a molar and second portion that is bonded to a distal cusp of the molar, and where the tube structure is provided to be located on the mesial cusp on the first portion of the base, and where the second base portion that is provided on the distal cusp does not have a tube structure thereon and, preferably, is substantially free of structure thereon that may interfere with surrounding teeth. | 2012-11-15 |
20120288816 | SELF LIGATING ORTHODONTIC BRACKET HAVING A ROTATABLE MEMBER - The present disclosure is directed, at least in part, to a self ligating orthodontic bracket having a rotatable member for securing an archwire within a slot of the bracket. Embodiments of the orthodontic bracket disclosed herein include a bracket body containing the archwire slot as well as tie wings for attaching various orthodontic devices (e.g., elastomeric bands) to the bracket. The rotatable member is rotatable in a first direction (e.g., counter clockwise) relative to a body of the bracket for securing or locking the archwire within the slot, and for rotating in an opposite direction (e.g., a clockwise direction) relative to the bracket body for unsecuring or unlocking the archwire so that it is substantially unrestrained from exiting the slot. | 2012-11-15 |
20120288817 | Orthodontic Devices - Orthodontic splint devices may include one or more bases and connectors. Various attachment members configured to, during use, couple the device to a portion of the patient's mouth may also be included on the device. In some implementations, a base may include an attachment member that includes a conduit and a sheath. Also provided are orthodontice devices comprising peripheral members and transpalatal members. The various orthodontic devices may move teeth individually or as a set in the subject's mouth. | 2012-11-15 |
20120288818 | METHOD OF MANAGING AN ORTHODONTIC ALIGNER SCHEDULE - A method of managing a schedule of orthodontic aligners ( | 2012-11-15 |
20120288819 | DENTAL IMAGING SYSTEM WITH ORIENTATION DETECTOR - This disclosure provides systems, methods, and apparatus for dental imaging. In one aspect, a hand piece, having a lens for capturing light for an image sensor, is configured for obtaining images of teeth in a mouth. The hand piece is provided with an orientation sensor, such as a gyroscope. The orientation sensor detects the roll, pitch, and yaw of the hand piece. In operation, an image of a tooth is captured at a reference position, and the roll, pitch, and yaw of the hand piece is determined at that position. The hand piece is moved to another position, and additional images of teeth in the mouth are not obtained until the orientation of the hand piece at the other position matches the orientation of the hand piece at the reference position. The reference and second images may be combined, and the similar orientations of the hand piece at the reference and second positions can facilitate the combination by ensuring that the reference and second images are obtained from similar perspectives. | 2012-11-15 |
20120288820 | DENTAL RF COIL, HEAD-FIXING UNIT, AND MAGNETIC RESONANCE IMAGING SYSTEM INCLUDING SAME - The invention relates to an MRI system, comprising: an examination table including a cradle in which a patient may be positioned; a magnetic assembly disposed in the examination table and including first and second electrode assemblies, the respective electrode surfaces of which are disposed so as to be perpendicularly spaced apart by a certain distance and opposite each other such that space for imaging may be formed therebetween; and an RF coil unit contactingly or contactlessly attached to a part of a patient to be examined or an attached part corresponding to the part to be examined, applying an RF pulse to the part of the patient to be examined, and detecting an MR signal from the examined part. | 2012-11-15 |
20120288821 | Dental Vacuum - An in-treatment room dental vacuum system includes a vacuum producer and an operator tool including an evacuator tip. A separator is coupled with the vacuum producer and is disposed between the vacuum producer and the operator tool. A hose assembly connects the operator tool and the separator. In use, the separator receives material from the operator tool via the hose assembly and separates the material into wet phase material and dry phase material. | 2012-11-15 |
20120288822 | Dental Hand Instrument having an Elongate Handle Sleeve - A dental hand instrument having an elongate handle sleeve, at the front end of which there are disposed means for holding a treatment tool, for example a dental drill, there are disposed inside the handle sleeve means for driving the treatment tool, which driving means have at least two rotatably mounted shafts that are coupled to each other, a sealing element being disposed in the coupling region of the two shafts inside the handle sleeve. | 2012-11-15 |
20120288823 | DENTAL HANDPIECE - A dental handpiece has a head section, a neck section, a grip section connected to the grip section, and a drive unit connected to the grip section. The handpiece also has detent means for preventing relative rotation between the neck and grip sections. The detent means includes a detent pin arranged axially slidably in the grip section, spring means for biasing the pin proximally so that the distal end of the pin is arranged inside the grip section in a rest position, and catch means formed at the proximal end of the neck section for receiving the pin for engagement. When the drive unit is brought into connection to the grip section, the pin is pressed distally to project out of the grip section into engagement in the catch means, to thereby prevent relative rotation between the neck section and the grip section. | 2012-11-15 |
20120288824 | DENTAL IMPLANT - The invention relates to a dental implant configured to be anchored in a jawbone for supporting a dental prosthesis. | 2012-11-15 |
20120288825 | ABUTMENT FOR A DENTAL IMPLANT - The invention relates to an abutment for connecting a dental prosthesis to a dental implant, the abutment comprising a body portion for supporting the dental prosthesis and a contact surface apical to said body portion for contacting the dental implant. | 2012-11-15 |
20120288826 | Dental Implants and Methods for Their Insertion into Patients - A dental implant includes a threaded fixture, at least a portion of which is configured for implantation into bone in a patient's jaw, and an abutment configured for coupling to the threaded fixture, at least a portion of which is configured to remain above the patient's gum line. The threaded fixture and/or the abutment are configured to receive torque from a complementarily shaped torque-transmitting tool. A method for inserting a dental implant into a patient includes (a) implanting at least a portion of a threaded fixture into a hole in a patient's jawbone configured for receiving the threaded fixture; (b) inserting an abutment into the threaded fixture, where at least a portion of the abutment is configured to remain above the patient's gum line; and (c) applying torque to a first part of the dental implant while simultaneously applying counter-torque to the threaded fixture and/or the abutment. | 2012-11-15 |
20120288827 | POLYAXIAL DENTAL IMPLANT SYSTEM - A dental implant system is described, including a lower implant body configured to be implanted in bone, and an upper implant body that couples to the lower body, thereby forming a cavity between upper and lower bodies. The system can further include a rotatable, swivelable anchor having a base at least partially disposed within the cavity. The anchor may have a shaft coupled to the base and extending through an opening in the upper body. The system may also include an abutment that couples to the shaft of the anchor and serves as a mounting area for a crown. The anchor's rotatability and swivelability allow the lower implant body to be implanted at an angle in bone while permitting the crown to be positioned in a natural tooth orientation. | 2012-11-15 |
20120288828 | SURFACE TREATMENT PROCESS FOR IMPLANTS MADE OF TITANIUM ALLOY - A titanium 6 Al/4V alloy is provided with a surface topography that is similar to the Osseotite® surface produced on commercially pure titanium. Native oxide is removed from the Ti 6Al/4V alloy, followed by contacting the metal at ambient temperature with an aqueous hydrochloric acid solution containing a relatively small amount of hydrofluoric acid. | 2012-11-15 |
20120288829 | Micro-Abrasive Blasting Device for Dental Applications and Methods - A micro-abrasive blasting device comprises a mixing chamber, a delivery conduit extending from external the mixing chamber to the mixing chamber and a discharge conduit extending from the mixing chamber. Abrasive material may selectively be sealed in the chamber by positioning the discharge conduit to abut the inlet port. The chamber may be spherical to deliver consistent powder perturbation at all mixing chamber orientations. Methods of using the device are disclosed. Methods of making the device by blow molding are disclosed. | 2012-11-15 |
20120288830 | Stun grenade with time delay trigger - A grenade simulator comprises a housing with an integral internal track. A carriage is mounted on the track for linear movement. A travel limit is provided at one end of the track to limit movement of the carriage on the track. A gas source is installed on the carriage. A drive spring installed between the carriage and the housing for urging the carriage against the travel limit. A multi-link trigger is installed on the housing for holding the carriage away from the travel limit until the multi-link trigger is released. A bayonet opens the gas source upon the carriage reaching the travel limit. A release delay is integral with the multi-link trigger. | 2012-11-15 |
20120288831 | G-CUEING SIMULATOR FOR HIGH-PERFORMANCE VEHICLES, IN PARTICULAR F1 CARS - A G-cueing simulator for a ground vehicle which includes a plurality of actuators which are operable to provide GO cues to a user in a simulated environment. | 2012-11-15 |
20120288832 | Interactive Educational Bingo - An interactive educational bingo game system that incorporates historical figures of United States history, potentially in the form of its Presidents, with the classic game of Bingo. Appropriate for children as well as adults, the game may be created for multiple players, individually or in teams. Players may only cover the historical figure on the bingo card if player correctly answers information pertaining to the historical figure. | 2012-11-15 |
20120288833 | System and Method for Language Instruction Using Multiple Prompts - A method of teaching a language to a student by an instructor is disclosed, wherein the method may include the steps of the instructor uttering a first prompting phrase to the student; receiving a first response from the student in response to the first prompting phrase; modifying at least one characteristic of the first prompting phrase to generate a second prompting phrase; and the instructor uttering the second prompting phrase to the student, wherein at least one of the above steps is performed using a computer. | 2012-11-15 |
20120288834 | VOICE LEARNING METHOD USING AN ELECTRONIC DEVICE - In a voice learning method using an electronic device, the owner of the electronic device is allowed to store a plurality of learning file units in a data storage unit of the electronic device. Each learning file unit includes an audio file having individual audio content to be learned. A number (N) of target learning file unit is selected from the learning file units stored in the data storage unit. When a communicating unit of the electronic device communicates with a communications network, an audio playing unit of the electronic device is enabled to play the audio files of the target learning file unit in order in response to incoming signals received by the communicating unit. | 2012-11-15 |
20120288835 | INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD - An information processing apparatus includes: a detecting unit that detects behavior information and biological information of a user as a target; a biological information estimating unit that calculates estimated biological information by applying, to a metabolism model, the behavior information and the biological information detected by the detecting unit; and a suggesting unit that suggests, to the user, a recommended behavior calculated based on the estimated biological information calculated by the biological information estimating unit. | 2012-11-15 |
20120288836 | God calling watch - The Lord has revealed a solution to me which will strengthen, bring Unity and Oneness in the body of Christ. This method process will serve as a blueprint to Christians in all denominations. The process will help Christians to apply the instructions given repeatedly by God himself, woven throughout his word. The new use device of watches and the process applied to cellular phones, iPads and iPods will be used to exalt the word of God. Christians will now have a useful device to help them pull down strong holds, to cast down imaginations and everything that exalt it's self against the knowledge of God, and to bring every thought into captivity to the obedience of Christ. The device will be used to help teach righteousness and holiness in the body of Christ. Because of my reverence to the awesome power of God's word; I can say that a multitude of good and marvelous manifestations will begin to surface in the body of Christ. They are countless. I cannot name them all. All instructions in the process are found in the word of God. This Holy watch and process will be used to serve humanity. The device will empower Christians from every denomination regardless of age all around the world. The final result will be Holy Sanctification of the body of Christ [The bride]. Based upon, Revelations 19:7 and Genesis 11:6 causing our Lord and Savior to appear Jesus Christ. | 2012-11-15 |
20120288837 | Medical Simulation System - A computerized educational apparatus ( | 2012-11-15 |
20120288838 | METHOD FOR SIMULATING A CATHETER GUIDANCE SYSTEM FOR CONTROL, DEVELOPMENT AND TRAINING APPLICATIONS - A system is disclosed for incorporating a realistic simulated catheter or catheters within a catheter guidance and control system that operate from the same closed-loop position control feedback and geometric mapping data as the real position control system and are able to make contact with real and simulated datasets. These catheters may be operated in a pure simulation mode without interacting with real catheters and position control hardware, or may be used as control cursors to enhance the placement of catheter positioning targets. The catheter tip, which is focus of magnetic control, is realistically guided by the control system parameters, while the remainder of the catheter line is realistically constrained by the mapped chamber geometry and introducer sheath. | 2012-11-15 |
20120288839 | SURGICAL SIMULATION MODEL AND METHODS OF PRACTICING SURGICAL PROCEDURES USING THE SAME - A surgical training simulation anatomical model for demonstrating, practicing, or evaluating a human lung surgical procedure is provided. The model includes a plurality of segments coupled together to form a skeletal frame representative of a portion of a human anatomy. The skeletal frame encloses at least a first component and a second component. The first component is representative of a patient's heart. A second component is representative of a patient's lung. The first component includes a plurality of hollow channels that extend at least partially through the second component for channeling pressurized fluid there through to simulate the behavior of a patient's heart and cardiopulmonary system during a surgical procedure of the patient's lung. The channels are oriented in a closed loop and include a plurality of nodes defined therein that are positioned to simulate lymph nodes in the patient. | 2012-11-15 |
20120288840 | CIRCULATORY HEART MODEL - A circulatory heart model ( | 2012-11-15 |
20120288841 | METHODS AND SYSTEMS FOR CLUSTERING STUDENTS BASED ON THEIR PERFORMANCE - Methods and systems of clustering a plurality of students are disclosed. A computing device may receive assessment data for each of a plurality of students. The assessment data includes information pertaining to each of a plurality of questions in an assessment. The computing device may also receive a number of clusters into which to organize the plurality of students. The computing device may determine a similarity value between each pair of students in the plurality of students based on the assessment data associated with each student. The computing device may organize the plurality of students into the number of clusters based on the similarity values. | 2012-11-15 |
20120288842 | Personalized Course Management System - Systems and methods for providing online courses are provided. A student seeking a higher education degree may enroll in courses, select, and control the timing and order of classes for a given program. Every course in a given program is available simultaneously. The courses are provided through a web-based instructional platform. Students can participate in one or more courses within one week of enrollment. A professor is assigned to the course. A professor can instruct more students and teach multiple courses simultaneously or in parallel, as opposed to the traditional classroom model. A student can personalize their enrollment and participate in the courses or progress through lessons of a course electronically through the web-based instructional platform via a software application on the smartphone, on their laptop and/or through an Internet browser at a particular website. | 2012-11-15 |
20120288843 | INTERACTIVE LEARNING SYSTEM AND METHOD - An interactive teaching and learning system and method is presented. In one aspect, the interactive teaching and learning system is a web-based cloud application in the form of a course design, teaching, learning and communication portal. | 2012-11-15 |
20120288844 | REVERSE MULTIPLE-CHOICE METHOD FOR KNOWLEDGE ENGINEERING AND EXPERT SYSTEM IMPLEMENTATION - A system and method of communication based on the Reverse Multiple-Choice Method of teaching and testing is disclosed where at least one communicant is a machine. The method is applicable for training a machine for knowledge engineering and artificial intelligence oriented applications, as well as for a trained machine to assist a human being engaged in the activity of teaching or testing. | 2012-11-15 |
20120288845 | ASSESSMENT FOR EFFICIENT LEARNING AND TOP PERFORMANCE IN COMPETITIVE EXAMS - SYSTEM, METHOD, USER INTERFACE AND A COMPUTER APPLICATION - The invention comprises a computer assisted answer recording method for e-learning, or e-assessment comprising: (a) recording an answer choice by the user of the said method for an objective type question by an answer selection submitting input action or by a marking action made on an said answer choices' answer choice input receiving element, the said action being integrated concurrently with the same action with quantified parameters of the said users' means of arriving at an answer choice and reasons, feelings, thoughts & needs recorded simultaneously by the said user as and when they have arisen in the mind of the said user while solving the said question & choosing the said answer choice, and (b) feeding the said integrated input to a computer programme that would analyse the results and transform them into statistical indices of performance parameters in a quantified way in reference to the said question and said test information and display the said statistical indices to the user. | 2012-11-15 |
20120288846 | E-LEARNING CONTENT MANAGEMENT AND DELIVERY SYSTEM - The present disclosure teaches a method and system for improving delivery of educational content. The content delivery system is based on best practices in classroom instruction, transferred into an online learning format. The lesson format includes short bursts of video-based instruction, interrupted by formative assessment in the form of multiple choice and multiple answer questions, in the same way a teacher would teach in a classroom. The system enables educators to import their own direct instruction content in the form of videos and add in their own questions and answer choices throughout the lesson, where appropriate. Further, the educator is also able to create his or her own summative assessment question items that incorporate material from multiple lessons. The educator also has the option of incorporating videos created by other sources or educators that can be found online. | 2012-11-15 |
20120288847 | LUGGAGE PACKING GUIDE - A template is used to limit over packing by a user. The user decides where the packing will take place. The template is unfolded and placed in that location. The user examines the template and decides which sections to use based upon the length of travel. Only those sections will be used and the other sections will remain empty. The user selects specific garments and personal items corresponding to markers in the sections and either places the selected items on, or otherwise associates the selected items with, the corresponding illustrations within the sections. Once the user is satisfied with the choices and all of the illustrations within the selected sections are filled, the user transfers the items from the template into a suitcase or packing device. | 2012-11-15 |
20120288848 | Multi-Dimensional Flow Pad Technology for Covering Three-Dimensional Dome Shaped Anatomies - A three dimensional dome wrap or pad for direct patient surface tissue applications for symmetrical dome shaped anatomy and extremities is disclosed herein. The pad of the present invention comprises a system of smooth streamline mathematically configured channels throughout one or more similarly shaped panels or lobes bonded distinctively to make one unit for the purpose of temperature management of three dimensional objects or subjects when it is applied or inserted. | 2012-11-15 |
20120288849 | METHOD AND SYSTEM FOR ROBUST AND SENSITIVE ANALYSIS OF BEAD-BASED ASSAYS - Computer-implemented methods and systems are provided for the analysis of multiplex fluorescent-dyed microsphere assays. The methods of the invention provide for determination of differences in analyte quantities between samples obtained from multiplex fluorescent-dyed microsphere assays by analysis of individual bead fluorescence and adjusting for variance; variance-stabilization of the data, and determining significance with hypothesis testing with tolerance determined by power estimation. The methods of the invention provide a benefit in allowing access to low signal or poor quality data, increased statistical power and decreased variability compared to standard curve methodology. | 2012-11-15 |
20120288850 | METHODS FOR DIAGNOSIS OF IMMUNE RESPONSES AGAINST VIRUSES - The present invention relates to methods for diagnosis of a cellular immune responses against a virus using an inactivated virus. In the method of the invention a cellular immune response against the virus is detected in a subject by incubating PBMCs from the subject with a preparation of inactivated virus and subsequently detecting the expression of at least one T cell specific cytokine in the subject's PBMCs, preferably by flow cytometry. Advantageously in the method, inactivated virus is used for incubation with PBMCs from the subject so as to make feasible that the method is performed in laboratories without BSL-3 classification. Preferably the method is a method for detecting a CD4+ and/or CD8+ T cell response against an influenza virus by detecting expression of one or more of CD107, IFN-γ, IL-2, IL-10 and TNF-α, using formalin inactivated influenza virus. The invention further pertains to kits comprising components that are useful for detecting a cellular immune responses in a subject against a virus. | 2012-11-15 |
20120288851 | Measurement System, Measurement Method, Program for Implementing the Method, and Recording Medium for the Program - The invention relates to a measurement system MS | 2012-11-15 |
20120288852 | Force Mediated Assays - A sensitive and specific method of detecting chemical species, viruses and microorganisms is presented to improve performance of molecular-recognition-based assays utilizing particles decorated with molecular recognition agents such as antibodies and DNA probes, and observing analyte-dependent changes in the response of the particles to forces such as magnetic or gravitational forces or Brownian thermal fluctuations. | 2012-11-15 |
20120288853 | METHODS FOR OPERATING CHEMICALLY SENSITIVE SENSORS WITH SAMPLE AND HOLD CAPACITORS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-11-15 |
20120288854 | AUTOMATED HIGH-THROUGHPUT SEED SAMPLER AND METHODS OF SAMPLING, TESTING AND BULKING SEEDS - An automated system for sampling seeds includes a seed loading station for separating individual seeds from a plurality of seeds held in a seed hopper, an imaging station configured to receive the separated seeds from the seed loading station and collect image data of the received seeds, and a seed sampling subsystem configured to remove tissue samples from the seeds after the image data of the seeds is collected. And, an automated method for sampling seeds includes separating individual seeds from a plurality of seeds, imaging the separated seeds, and removing tissue samples from the imaged seeds. | 2012-11-15 |
20120288855 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use - Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA. | 2012-11-15 |
20120288856 | MOLECULAR SEXING OF AVIAN SUBJECTS - The present invention provides oligonucleotides including amplification primers and probes as well as pairs of said oligonucleotides that are useful in methods and uses for the determination of the sex of an avian subject. Similarly, these oligonucleotides can be used for the preparation of a kit for the determination of the sex of an avian subject. Also, the present invention provides a method for the identification of a pair of oligonucleotides for sexing of an avian subject and a kit comprising such oligonucleotides. | 2012-11-15 |
20120288857 | MULTIFUNCTIONAL PROBE-PRIMERS - Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined. The detection step makes use of a multifunctional “self-digesting” molecular probe comprising a primer polynucleotide and a probe oligonucleotide, linked in a 5′-5′ orientation. | 2012-11-15 |
20120288858 | ASSESSING SMALL CELL LUNG CANCER OUTCOMES - This document provides methods and materials involved in assessing lung cancer (e.g., SCLC). For example, methods and materials for identifying a mammal having lung cancer (e.g., SCLC) as being susceptible to a poor outcome are provided. | 2012-11-15 |
20120288859 | Probe for Detecting Poly A Repeat Number Polymorphism of HGF Gene and Uses Thereof - The present disclosure relates to probes for detecting a polymorphism of HGF gene. | 2012-11-15 |
20120288860 | DIFFERENTIAL GENE EXPRESSION FOR DETECTING AND/OR DIFFERENTIATING LUNG DISEASE - Disclosed herein are methods, constructs, kits, and the like, which can be used for detecting and/or differentiating interstitial lung disease. For example, idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) can be detected and/or differentiated using at least one biomarker. | 2012-11-15 |
20120288861 | GERMLINE POLYMORPHISMS IN THE SPARC GENE ASSOCIATED WITH CLINICAL OUTCOME IN GASTRIC CANCER - This disclosure provides compositions and methods for determining the likely tumor recurrence of gastric cancer patients based on genomic polymorphisms of the SPARC gene. The disclosure also provides compositions and methods for selecting gastric cancer patients for appropriate treatments and methods of treating them. | 2012-11-15 |
20120288862 | KITS FOR QUANTITATIVE DETECTION OF K-RAS MUTATIONS - The present invention relates to an assay kit for quantitatively detecting k-ras gene mutations. Particularly, the present invention relates to detection method and a detection kit for K-ras gene mutations, which relates to the therapeutic efficacy of targeted molecular anti-cancer drugs. More particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of K-ras gene, together with the use thereof. The present invention detects the mutations at specific sites of K-ras gene, and can predict the therapeutic efficacy of anti-EGFR tyrosine kinase inhibitors. Therefore, it can provide a guidance to individualized treatments for cancer patients. | 2012-11-15 |
20120288863 | Oligonucleotides and methods for detecting KRAS and PIK3CA mutations - Provided are oligonucleotides that are capable of detecting KRAS and PIK3CA mutations in both cancer patients and healthy individuals with high specificity in kPCR assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of KRAS codon 12, 13, and 61 and PIK3CA codon 542, 545, and 1047 single nucleotide polymorphisms (SNPs) in a background of wild-type sequences. The oligonucleotides of the present invention are also capable of preventing pseudogene amplification when the oligonucleotides are hybridized as reverse primers or detection probes to the mismatch sequences. | 2012-11-15 |
20120288864 | DETECTION OF SALMONELLA BY REAL-TIME MULTIPLEX PCR - The invention relates to the detection of | 2012-11-15 |
20120288865 | METHOD AND APPARATUS FOR GENERATING THERMAL MELTING CURVES IN A MICROFLUIDIC DEVICE - The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products. | 2012-11-15 |
20120288866 | SYSTEMS AND METHODS FOR PRODUCING AN EVAPORATION BARRIER IN A REACTION CHAMBER - The embodiments described herein relate to systems and methods for producing an evaporation barrier in a PCR vial. In some embodiments, beads with a particular distribution in diameters can be used to produce a barrier for reducing the evaporation of liquid PCR samples within the PCR vial. In some embodiments, the beads can be pre-filled in the PCR vial. In use, liquid samples and/or liquid reagents can be introduced in the PCR vial pre-filled with the beads, such that the beads can be driven to the surface of the liquid PCR sample through the buoyancy of the beads. | 2012-11-15 |
20120288867 | SERIAL ISOLATION OF MULTIPLE DNA TARGETS FROM STOOL - Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from human stool samples. | 2012-11-15 |
20120288868 | ISOLATION OF NUCLEIC ACIDS - Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool. | 2012-11-15 |
20120288869 | Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts - Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. | 2012-11-15 |
20120288870 | Means for the inhibition of anti-beta1-adrenergic receptor antibodies - Embodiments of the present invention provide for novel peptides of use for detection and/or inhibition of anti-β1-adrenergic receptor antibodies. Certain embodiments concern uses of cyclic and/or linear peptides. In other embodiments, the present invention relates to novel peptides of use in diagnostic and/or pharmaceutical compositions. Some embodiments concern diagnosing and/or treating cardiac conditions. Cardiac conditions of the instant invention can concern infectious heart disease, non-infectious heart disease, ischemic heart disease, non-ischemic heart disease, inflammatory heart disease, myocarditis, cardiac dilatation, idiopathic cardiomyopathy, idiopathic dilated cardiomyopathy, immune-cardiomyopathy, heart failure, and any cardiac arrhythmia condition. | 2012-11-15 |
20120288871 | Modified Carbocyanine Dyes and Their Conjugates - Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens. | 2012-11-15 |
20120288872 | GENE DEFECTS AND MUTANT ALK KINASE IN HUMAN SOLID TUMORS - Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides. | 2012-11-15 |
20120288873 | BIOMARKERS FOR THE DETECTION AND SCREENING OF DOWN SYNDROME - The disclosure includes assays and methods for screening for risk of Down syndrome and/or trisomy 21 in a fetus. The assays and methods comprise determining the level of at least one biomarker selected from mucin 13 (MUC13), bile salt-activated lipase (CEL), dipeptidyl peptidase 4 (DPP4), carboxypeptidase A1 (CPA1), amyloid precursor protein (APP) and tenascin-C (TNC-C) polypeptides in a test biological sample from a pregnant subject, wherein a decreased level of MUC13, CEL, DPP4, and/or CPA1 polypeptide and/or an increased level of APP and/or TNC-C polypeptide in the test biological sample compared to a corresponding reference biomarker polypeptide level indicates an increased risk of Down syndrome or trisomy 21 in the fetus. The disclosure also includes assays, compositions, immunoassays, and kits for performing the methods disclosed herein. | 2012-11-15 |
20120288874 | ENZYMATIC ACTIVITY-BASED DETECTION - Disclosed herein are methods and kits which are useful for detecting presence of an enzyme in a test sample based upon the intrinsic enzymatic activity of such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes. | 2012-11-15 |
20120288875 | Diagnostic Test For The Detection Of A Molecule Or Drug In Whole Blood - The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits. | 2012-11-15 |
20120288876 | NOVEL IDENTIFIED ONCOGENE WITH KINASE-DOMAIN (NOK) - A newly identified oncogene with kinase domain (NOK) and its encoded polypeptide, and vectors, fusions, host cells and transgenic animals comprising the said nucleotide sequence. Furthermore, the present invention also describes the methods for diagnosing diseases including tumor and the methods for screening agents capable of inhibiting the occurrence and/or metastasis of tumor. | 2012-11-15 |
20120288877 | ELECTROCHEMICAL METHODS OF DETECTING COLON CANCER CELLS AND USE OF SAME FOR DIAGNOSING AND MONITORING TREATMENT OF THE DISEASE - A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy. | 2012-11-15 |
20120288878 | METHODS FOR IDENTIFYING IMMUNOBINDERS OF CELL-SURFACE ANTIGENS - The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods. | 2012-11-15 |
20120288879 | METHODS FOR DEVELOPING AND ASSESSING THERAPEUTIC AGENTS - Assays are provided that can effectively assess tumor response to one or more therapeutic agents. Preferred assays of the invention include assessment of posttranslation modification and expression of target proteins. | 2012-11-15 |
20120288880 | METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE - The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject. | 2012-11-15 |
20120288881 | Method for Evaluating the Cure Level of Stroke - A method for evaluating the cure level of a stroke patient comprises following steps: (1) obtaining isolated blood sample from said stroke patient; (2) determining the concentration of serum granulocyte colony-stimulating factor (G-CSF) of said blood sample; (3) comparing the relationship between said concentration of granulocyte colony-stimulating factor (G-CSF) and the stroke severity ranking of said stroke patient; wherein United State National Institute of Health Stroke Scale (NIHSS) or modified Ranking Scale (mRS) is used in said stroke severity ranking ; and (4) Using said concentration of granulocyte colony-stimulating factor (G-CSF) to predict the possible cure level of said stroke patient. The invention further provide a prognosis biomarker for evaluating the cure level of a stroke patient, and a kit containing said prognosis biomarker. | 2012-11-15 |
20120288882 | TYPE IV SECRETION SYSTEM PROTEINS IN SERO-DETECTION OF ANAPLASMA PHAGOCYTOPHILUM - Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in | 2012-11-15 |
20120288883 | PROBE REAGENT FOR MEASUREMENT OF PROTEOLYTIC ACTIVITY - This invention relates to a probe reagent comprising, in order from the N-terminus to the C-terminus, the amino acid sequences of a fluorescent protein I, a peptide capable of terminating protein degradation (i.e., a degradation-terminating peptide), a spacer peptide, a fluorescent protein II, and a protein to be degraded, wherein the protein to be degraded is a protein degraded by the ubiquitin-proteasome system, and the probe reagent is degraded from the C-terminus, but that the degradation of the probe reagent is terminated at the degradation-terminating peptide, a nucleic acid encoding the probe reagent, and use of the probe reagent or the nucleic acid. | 2012-11-15 |
20120288884 | QUINAZOLINONE BASED FLUOROGENIC PROBES - The present invention relates to a compound of the general formula (I) useful in the determining the presence, amount or activity of an enzyme in living cells, a method of preparing said compounds and a kit thereof. | 2012-11-15 |
20120288885 | METHOD AND KIT FOR MEASURING ENZYMATIC ACTIVITIES OF VARIOUS CYTOCHROME P450 MOLECULE SPECIES COMPREHENSIVELY AND WITH HIGH EFFICIENCY - The present invention relates to a method, and a kit, for measuring the enzymatic activity of cytochrome P450 comprehensively and with high efficiency and accuracy, wherein an oxygen sensing layer and a cytochrome P450-supporting layer are vertically integrated on a chip, and cytochrome P450 is supported in a hydrophilic polymer matrix in the cytochrome P450-supporting layer,
| 2012-11-15 |
20120288886 | INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA - The present invention is directed to a method of treating hypophosphatemia in a subject. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed. | 2012-11-15 |
20120288887 | BLOOD CELL AGGLUTINATION IMAGE DETERMINING METHOD AND BLOOD CELL AGGLUTINATION IMAGE DETERMINING APPARATUS - The present invention provides a blood cell agglutination image determining method and a blood cell agglutination image determining apparatus capable of processing a blood sample in a short time and obtaining a reproducible determination result. Provided are a blood cell agglutination image determining method and a blood cell agglutination image determining apparatus for determining a blood sample to be positive or negative based on a blood cell agglutination image of a reaction between a blood sample and a reagent in a reaction container. The apparatus comprises: a rotation mechanism R for rotating a reaction container so that a bottom wall of the reaction container will turn outwards by centrifugal force; and an inclining apparatus | 2012-11-15 |
20120288888 | MICROBIAL DETECTION ARTICLE - The disclosure provides an article for the detection of a microorganism in a liquid sample. The article comprises a microporous membrane and a barrier layer to selectively regulate the contact between the sample and a detection reagent. A method of use is also provided. | 2012-11-15 |
20120288889 | REAGENT FOR BLOOD CELL COUNTING AND BLOOD ANALYSIS METHOD - Disclosed is a novel reagent for blood cell counting and a novel blood analysis method, which enable blood cells such as leukocytes to be counted with high accuracy by dissociating platelet aggregates in capillary blood collected from a living body. The reagent for blood cell counting is used to dilute capillary blood collected from a living body to prepare a blood sample in order to count blood cells in the collected capillary blood using a particle analyzer, and is an aqueous solution containing a chloroquine salt. | 2012-11-15 |
20120288890 | MICROBIAL COUNTING CELL, MICROBE COUNTING DEVICE USING SAME, AND MICROBE COUNTING METHOD USING SAME - A microorganism counting cell of the present invention includes bottomed cylindrical vessel that includes upper surface opening and cylindrical retaining body disposed vertically on a bottom surface in vessel, a collecting element provided on a lower end portion of a rod-shaped cotton swab being inserted in retaining body from upper surface opening. In the microorganism counting cell, elution protrusion is provided on an interior side surface of retaining body, and elution groove that pierces retaining body from an inside to an outside is provided on a side surface of retaining body. | 2012-11-15 |
20120288891 | PRODUCTION OF ACETYL-COENZYME A DERIVED COMPOUNDS - The present disclosure relates to the use of pantothenate compounds as a non-genetic switch for the production of heterologous acetyl-CoA derived (HACD) compounds in microbial host cells. The invention provides genetically modified microorganisms that are more stable when stored and initially cultured under reduced pantothenate concentrations, cell culture media having reduced concentrations of pantothenate compounds, and methods of producing HACD compounds using the cell culture media and the genetically engineered microorganisms of the invention. | 2012-11-15 |
20120288892 | Methods for Producing Polypeptidies in Protease-Deficient Mutants of Trichoderma - The present invention relates to mutants of a parent | 2012-11-15 |
20120288893 | SEED-SPECIFIC EXPRESSION VECTOR AND ITS CONSTRUCTION METHODS AND APPLICATIONS - A seed-specific expression vector and its construction methods and applications are disclosed. A fusion protein expression cassette consisting of | 2012-11-15 |
20120288894 | BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC AND HAVING REDUCED TSP ACTIVITY - The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC and has reduced Tsp protein activity compared to a wild-type cell. | 2012-11-15 |
20120288895 | Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V - Methods for the treatment of coagulation disorders using Factor V/Va variants are provided. | 2012-11-15 |
20120288896 | NUCLEIC ACID MOLECULES ENCODING ANTI-AMYLOID-BETA ANTIBODIES - The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD). | 2012-11-15 |
20120288897 | APPARATUS AND METHODS FOR INTEGRATED SAMPLE PREPARATION, REACTION AND DETECTION - An apparatus includes a housing, a reaction vial and a transfer mechanism. The housing defines a first flow path and a second flow path. The housing has transfer port defining an opening in fluid communication with the second flow path and a volume outside of the housing. The transfer port includes a flow control member to limit flow through the opening. The reaction vial is coupled to the housing and defines a reaction volume, which is in fluid communication with the transfer port via the second flow path. The transfer mechanism is configured to transfer a sample from an isolation chamber of an isolation module to the reaction chamber via at least the first flow path when the transfer mechanism is actuated. The transfer mechanism configured to produce a vacuum in the reaction vial to produce a flow of a sample from the isolation chamber to the reaction volume. | 2012-11-15 |