43rd week of 2010 patent applcation highlights part 40 |
Patent application number | Title | Published |
20100273140 | APPAREL DRESSING SYSTEM AND METHOD FOR ASSISTING USER TO TRY ON APPAREL ITEM - An apparel dressing system includes a display, a RFID configured for identifying a RFID tag proximate thereto and retrieving data from the RFID tag, a sensor for taking an image and/or physical parameters of the user, and a processing unit connected with the display, the RFID reader and the sensor. The RFID tag is attached to an apparel item selected by a user and contains product identification information of the apparel item. The processing unit is configured for processing the product identification information retrieved from the RFID tag and the image and/or the physical parameters of the user taken by the sensor. The processing unit is also configured for showing information related to the apparel item and the user on the display. | 2010-10-28 |
20100273141 | Glycine stabilized lyophilized plasma - The invention is directed to stabilized whole-cell plasma, which retains the integrity and overall stability of the proteins and other macromolecules of the plasma. Stabilization is accomplished by the addition of glycine to plasma which allows for stabilization prior to freeze drying. Glycine, in the presence of the salt concentration in the plasma, does not recrystallize and acts as a superior stabilizer for the lyophilized plasma. The stability of the freeze dried plasma may be further improved by addition of protectants including calcium chloride, trisodium citrate, hydroxyethyl starch, ammonium sulfate and citric acid to maintain physiologic pH. Superior stability for a wide variety of plasma proteins and functions is shown. A system for the large scale preparation of sterile lyophilized plasma is also provided. | 2010-10-28 |
20100273142 | MULTI-COMPARTMENT DEVICE WITH MAGNETIC PARTICLES - The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles. | 2010-10-28 |
20100273143 | DISCRIMINATORY POSITIVE/EXTRACTION CONTROL DNA - The present teachings generally relate to methods and kits incorporating a discriminating positive control for determining whether a particular microorganism or group of microorganisms are present in a sample, for example but not limited to a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample. According to certain methods, at least part of a starting material, for example but not limited to, a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample can be combined with a culture medium and incubated under conditions suitable for microbial growth followed by extracting microorganism and added control nucleic acids for analysis. The extracted nucleic acids are amplified and the amplified nucleic acids are detected, directly or indirectly, and the fidelity of the methods and the presence or absence of the corresponding microorganism is determined because the discriminating positive control provides both confirmatory results for the methods used but eliminates false positive results. | 2010-10-28 |
20100273144 | NOVEL USE OF GRP 94 IN VIRUS INFECTION - A novel use of GRP 94 in treatment of virus infection is provided. More specifically, a method of inhibiting virus infection by inhibiting expression of GRP 94 and/or inactivating activity of GRP 94, and a method of developing drugs for preventing and/or treating virus infection and/or diseases caused by virus infection by using GRP 94 as a target are provided. | 2010-10-28 |
20100273145 | ASSAY METHOD UTILIZING POLYNUCLEOTIDE SEQUENCES - A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex. | 2010-10-28 |
20100273146 | TB resistance assay - A diagnostic test for detecting multi-drug resistant | 2010-10-28 |
20100273147 | Medical diagnostic system and methods - A system and methods are provided for a medical diagnostic system that incorporates a genetically encoded digital signature to authenticate a patient. In an illustrative implementation, a platform is provided performing one or more functions including but not limited to patient authentication, diagnostics, transmission, and storage of data in a centralized secure database capable of being accessed by healthcare professionals. In the illustrative implementation, the exemplary medical diagnostic system can comprise a genetic material collector/analyzer. Responsive to inputting genetic material in the collector/analyzer, the collector/analyzer generates a unique genetic-based electronic signature representative of the genetic material. The unique genetic-base electronic signature can then be processed by cooperating parties to authenticate the person providing the genetic sample. In the illustrative operation, such comparison can be accomplished by comparing the generated unique genetic-based electronic signature with a stored genetic-based electronic signature as part of a patient authentication process. | 2010-10-28 |
20100273148 | Urine markers for detection of bladder cancer - Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention. | 2010-10-28 |
20100273149 | PHOTOSYNTHETIC HYDROGEN PRODUCTION FROM THE GREEN ALGA CHLAMYDOMONAS REINHARDTII - The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced hydrogen. Specifically, disclosed is a method for producing bacteria and green alga that can produce hydrogen in quantities that exceed four hundred percent of the hydrogen produced by green alga in nature; thus, producing organisms which can serve as hydrogen generators for fuel cells, chemical production and numerous other applications. | 2010-10-28 |
20100273150 | SINGLE MOLECULE-FORMAT BIOLUMINESCENT PROBE - This application aims to provide a single molecule-format probe for detecting a target-specific ligand easily and accurately as an index of the presence or absence of a signal. | 2010-10-28 |
20100273151 | GENOME-WIDE ANALYSIS OF PALINDROME FORMATION AND DNA METHYLATION - The present disclosure provides methods for detecting the genome-wide presence of methylated DNA and palindrome formation. The present disclosure also provides methods for specific enrichment of methylated DNA or DNA having a DNA palindrome. These methods have demonstrated that somatic palindromes and methylated DNA occur frequently and are widespread in human cancers. Individual tumor types have a characteristic non-random distribution of palindromes in their genome and a small subset of the palindromic loci are associate with gene amplification. The disclosed method can be used to define the plurality of genomic DNA palindromes and regions having methylated DNA associated with various tumor types and can provide methods for the classification of tumors, and the diagnosis, early detection of cancer as well as the monitoring of disease recurrence and assessment of residual disease. | 2010-10-28 |
20100273152 | METHOD OF IDENTIFYING INDIVIDUALS AT RISK OF THIOPURINE DRUG RESISTANCE AND INTOLERANCE - The present invention is directed to a method of screening individuals for the presence or absence of one or more polymorphisms associated with the risk of thiopurine resistance or intolerance. | 2010-10-28 |
20100273153 | GENETIC DIAGNOSIS OF DEPRESSION - The present invention relates to compositions and methods for determining whether an individual is predisposed to major depressive disorder and/or to bipolar disorder. In particular, the present invention provides genetic markers useful alone or in combination with other genetic markers for the diagnosis, characterization and treatment of major (unipolar) depression and/or bipolar disorder. | 2010-10-28 |
20100273154 | NOVEL GLYCOSYLTRANSFERASES AND POLYNUCLEOTIDES ENCODING THE SAME - The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus | 2010-10-28 |
20100273155 | DETERMINATION OF QUALITY FEATURES IN AGRICULTURAL AND HORTICULTURAL CROPS - The present invention relates to a method for predicting the expected value of the quality features in agricultural and horticultural product and a method for predicting the expected optimal time of harvest by comparing expression parameters at the moment prior to harvest or during the postharvest path of genes and/or proteins related to such quality features for that agricultural and horticultural product, with (a) predetermined calibration line(s). The invention also comprises the markers M8, GAST and GDSL motif lipase and the uses thereof, as well as antibodies against them. | 2010-10-28 |
20100273156 | SEQUENCES AND METHODS FOR DETECTING INFLUENZA A AND INFLUENZA B VIRUS - Nucleic acid amplification primers and methods for specific detection of influenza A and influenza B nucleic acid targets are disclosed. The primer-target binding sequences are useful for detection of influenza A and influenza B targets in a variety of amplification and hybridization reactions. The oligonucleotide sequences are able to differentiate between influenza A and influenza B strains through specific hybridization to one or the other virus strain, enabling specific detection of the presence of influenza A and/or influenza B in a specimen. | 2010-10-28 |
20100273157 | System and Method for Authentication or Identification of Bio-Artifacts Related to President Abraham Lincoln - An invention for authenticating artifacts related to President Abraham Lincoln is presented. In an embodiment of the invention, an artifact is identified. The artifact has a biologically-derived component (“bio-component”). At least a portion of the bio-component is processed to yield matter that may be analyzed. This matter is analyzed and the analysis results interpreted. The interpretation is based on information related to a syndrome of marfanoid habitus and stable multiple lip dysmorphisms (an “MH/LD syndrome”). Two such syndromes are multiple endocrine neoplasia type 2B and pure mucosal neuroma syndrome. Other such syndromes may exist. Evidence of an MH/LD syndrome in the analysis results is evidence that the artifact is authentically associated with President Lincoln. A report is optionally produced. | 2010-10-28 |
20100273158 | HIN-1, A Tumor Suppressor Gene - The invention encompasses isolated DNAs encoding HIN-1 polypeptides, vectors containing such DNAs, cells containing the vectors, and isolated HIN-1 polypeptides. The invention also features methods of making and using HIN-1 polypeptides. | 2010-10-28 |
20100273159 | Nested Multiplex Amplification Method for Identification of Multiple Biological Entities - The present invention provides a novel molecular method for the simultaneous identification and semi-quantification of multiple targeted biological entities from amongst a plurality. This invention discloses a method based on a multiplex nested amplification reaction in a single closed tube. The first amplification reaction relies on a set of large oligonucleotides for the amplification of common loci in all the targeted biological entities. The second nested amplification reaction relies on a set of short oligonucleotide primers that amplifies specific nucleotide sequences from all the amplicons previously produced in the first amplification reaction and generates an amplified product pattern capable of identifying each targeted biological entity. This method offers fast and accurate simultaneous identification of many targeted biological entities in any sample. | 2010-10-28 |
20100273160 | METHODS TO IDENTIFY AND ENRICH FOR POPULATIONS OF OVARIAN CANCER STEM CELLS AND SOMATIC OVARIAN STEM CELLS AND USES THEREOF - The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells. | 2010-10-28 |
20100273161 | DETECTION OF BACTERIA BELONGING TO THE GENUS CAMPYLOBACTER BY TARGETING CYTOLETHAL DISTENDING TOXIN - An objective of the present invention is to provide the cytolethal distending toxin (CDT) of | 2010-10-28 |
20100273162 | RAPID DETECTION OF MICROORGANISMS - Methods for rapidly detecting Enterobacteriaceae and Micrococcaceae microorganisms utilizing non-amplified nucleic acids, acridiniu labeled ONA probes, and selective growth media are described, particularly for specific microbial species related to the food science industry and public health. Articles of manufacture that include reagents for detecting multiple microorganisms simultaneously are also described. | 2010-10-28 |
20100273163 | Methods for Identifying Agents that Inhibit Cell Migration, Promote Cell Adhesion and Prevent Metastasis - Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility. | 2010-10-28 |
20100273164 | Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation - Methods and compositions for determining a methylated cytosine profile of a target nucleic acid sequence are provided. | 2010-10-28 |
20100273165 | PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON INVASIVE PRENATAL DIAGNOSES - Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies. | 2010-10-28 |
20100273166 | BIOSENSOR DEVICE AND METHOD OF SEQUENCING BIOLOGICAL PARTICLES - A biosensor device ( | 2010-10-28 |
20100273167 | METHODS FOR DETERMINING PRENATAL ALCOHOL EXPOSURE - Provided herein are methods for determining ethanol exposure of a prenatal subject, including measuring whether or not amniotic fluid stem cells collected from amniotic fluid surrounding the prenatal subject have a upregulation or expression of one or more genes of a first predetermined combination and/or a downregulation of expression of one or more genes of a second predetermined combination. Also provided are methods for determining ethanol exposure of a prenatal subject which methods include measuring alkaline phosphatase activity and/or calcium deposition of amniotic fluid stem cells collected from amniotic fluid surrounding the prenatal subject. | 2010-10-28 |
20100273168 | METHOD FOR DISCRIMINATING RED BLOOD CELLS FROM WHITE BLOOD CELLS BY USING FORWARD SCATTERING FROM A LASER IN AN AUTOMATED HEMATOLOGY ANALYZER - A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by means of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells. | 2010-10-28 |
20100273169 | QUANTITATIVE PCR-BASED COMPOSITIONS AND METHODS FOR THE DIAGNOSIS OF INVASIVE PULMONARY ASPERGILLOSIS - Provided are quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis (IPA) in a patient sample, such as bronchoalveolar lavage (BAL) fluid. The methods presented herein involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR (qPCR) reaction on the sample to generate an amplicon that includes a region of an | 2010-10-28 |
20100273170 | METHOD AND DEVICE FOR PREPARING BIOLOGICAL SAMPLES FOR ANALYSIS - The invention relates to a method for preparing biological samples for analysis, comprising the following steps: (a) the biological sample is placed on a two-dimensional support; (b) application of a protein-precipitating or denaturing first solution L | 2010-10-28 |
20100273171 | GLOBAL GENE EXPRESSION ANALYSIS OF HUMAN BRONCHIAL EPITHELIAL CELLS EXPOSED TO CIGARETTE SMOKE, SMOKE CONDENSATES, OR COMPONENTS THEREOF - Aspects of the present invention concern the identification of several methods to analyze the genes that are modulated in normal human bronchial epithelial (NHBE) cells after exposure to cigarette smoke condensates (CSC) or cigarette smoke (CS). Embodiments described herein include methods to identify a gene that is modulated in response to exposure to CSC or CS, methods to identify tobacco products that have a reduced potential to contribute to tobacco-related disease, methods to make tobacco products that have a reduced potential to contribute to a tobacco-related disease, methods to identify a subject's predilection to acquire a tobacco related disease, the use of particular genes as biomarkers for tobacco-related disease, and patterns of gene expression or genetic signatures that are unique to each particular tobacco product. | 2010-10-28 |
20100273172 | MICRORNAS EXPRESSION SIGNATURE FOR DETERMINATION OF TUMORS ORIGIN - The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy. | 2010-10-28 |
20100273173 | METHOD FOR AMPLIFYING TARGET NUCLEIC ACID SEQUENCE AND PROBE USED FOR THE SAME - The present invention provides a method for amplifying a target sequence while suppressing inhibition of an amplification reaction in nucleic acid amplification in the presence of the probe. At the time of amplifying the target sequence, as the probe caused to coexist in amplification of the target sequence, a probe having a base sequence in which a melting temperature of the double-stranded nucleic acid is equal to or lower than a reaction temperature of the elongation reaction is used. In the presence of such a probe, for example, annealing of a primer and an elongation reaction from the primer are hardly inhibited by the presence of the probe so that amplification of the target sequence can be conducted sufficiently. Therefore, when a polymorphism of a target site in the target sequence is analyzed by a Tm analysis or the like, high reliability can be achieved. | 2010-10-28 |
20100273174 | ANTIBODIES TO TUMOR ASSOCIATED PROTEINS - A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization. | 2010-10-28 |
20100273175 | METHOD OF JUDGING RISK FOR ONSET OF DRUG-INDUCED GRANULOCYTOPENIA - Means for determining the presence of the risk of drug-induced granulocytopenia in a human is provided. | 2010-10-28 |
20100273176 | METHOD OF JUDGING RISK FOR ONSET OF DRUG-INDUCED GRANULOCYTOPENIA - Means for determining the presence of the risk of drug-induced granulocytopenia in a human is provided. | 2010-10-28 |
20100273177 | Methods and Devices for Testing Saliva - Provided are methods and devices for performing sensitive, rapid antigen testing of saliva, which yield sensitivity comparable to both rapid antigen tests and saliva culture. | 2010-10-28 |
20100273178 | Affinity selected signature peptides for protein identification and quantification - A method for protein identification in complex mixtures that utilizes affinity selection of constituent proteolytic peptide fragments unique to a protein analyte. These “signature peptides” function as analytical surrogates. Mass spectrometric analysis of the proteolyzed mixture permits identification of a protein in a complex sample without purifying the protein or obtaining its composite peptide signature. | 2010-10-28 |
20100273179 | METHOD FOR TESTING OR SCREENING PROTEIN SYNTHESIS INHIBITORS - This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus. Additionally, the invention provides a kit and a system for screening protein synthesis inhibitors in a cell. | 2010-10-28 |
20100273180 | DECORIN POLYPEPTIDE AND METHODS AND COMPOSITIONS OF USE THEREOF - The present invention provides methods for decreasing expression of a decorin polypeptide in a cell, methods for identifying an agent that alters, preferably decreases, the distribution of decorin polypeptide in a cell, and methods for determining a prognosis for oral cancer in a subject through the use of a compound that binds decorin polypeptide. Also provided are antibodies that specifically bind decorin polypeptides and double stranded polynucleotides, for instance, dsRNAs, that inhibit expression of a polynucleotide encoding a decorin polypeptide. | 2010-10-28 |
20100273181 | METHODS FOR THE DETECTION OF GLYCATED HEMOGLOBIN - Particular aspects of the present invention relate to methods for detecting glycated hemoglobin in, for example, human whole blood, that are not affected by the presence of variation in amino acid sequence that can exist in hemoglobin β chains. The methods detect all glycated hemoglobin in a sample, regardless of the form of the hemoglobin that has been glycated, and thus detect glycated human Hemoglobin A, Hemoglobin S, and Hemoglobin C. | 2010-10-28 |
20100273182 | Truncated Proteins As Cancer Markers - Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X | 2010-10-28 |
20100273183 | DIAGNOSTIC ASSAY FOR ANTI-VON WILLEBRAND FACTOR CLEAVING PROTEASE (ADAMTS13) ANTIBODIES - This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy. | 2010-10-28 |
20100273184 | DEVICE FOR MAGNETIC DETECTION OF INDIVIDUAL PARTICLES IN A MICROFLUID CHANNEL - A device dynamically detects particles of a fluid. The device can be miniaturized for detecting and selecting magnetized particles, particularly cells. | 2010-10-28 |
20100273185 | Detection of Biased Agonist Activation - The invention provides single assay methods to detect the activity of biased agonists or agonists that are less than full agonists on cells. | 2010-10-28 |
20100273186 | SPLIT MUTANT HYDROLASE FUSION REPORTER AND USES THEREOF - The invention provides polynucleotides encoding and polypeptides corresponding to split hydrolase fusion proteins, wherein the hydrolase sequence may include at least one substitution, and use of the split hydrolase fusion proteins. | 2010-10-28 |
20100273187 | ANTIBODIES AGAINST DELTA-5 DESATURASE AND USES THEREOF - Disclosed are antibodies that specifically recognize Δ5-desaturase, methods of producing the antibodies, nucleotides and polypeptides for producing the antibodies, and methods of using the antibodies. The Δ5-desaturase-specific antibodies provide improved methods of detecting Δ5-desaturase in a sample. | 2010-10-28 |
20100273188 | Serum Prolactin Binding Protein in Epithelial Carcinoma - The present invention relates to antibodies that have specificity towards prolactin binding protein (PRLBP) that is either bound to a binding partner or unbound to a binding partner, as well as antibodies towards PRLBP regardless of the binding state of PRLBP. The present invention also provides methods of using these PRLBP-specific antibodies, such as method of diagnosing and monitoring the progression of diseases such as epithelial carcinomas, osteoporosis, infertility and cachexia. | 2010-10-28 |
20100273189 | NON SEPARATION ASSAYS WITH SELECTIVE SIGNAL INHIBITORS - Methods, reagents, kits and systems are disclosed for determining an analyte in a sample, the assay method comprising forming a reaction mixture in an aqueous solution, by adding a chemiluminescent-labeled immobilized specific binding member, an activator-labeled specific binding member, a selective signal inhibiting agent, and a sample, wherein the chemiluminescent-labeled immobilized specific binding member and activator-labeled specific binding member bind to analyte present in the sample to form a binding complex, and adding to the reaction mixture a trigger solution to release a detectable chemiluminescent signal correlated to the amount of the analyte-bound binding complex present in the reaction mixture. | 2010-10-28 |
20100273190 | PKHDL1, A HOMOLOG OF THE AUTOSOMAL RECESSIVE KIDNEY DISEASE GENE - Nucleic acids encoding fibrocystin-L polypeptides and fibrocystin-L polypeptides are provided. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids and polypeptides, and compositions and articles of manufacture also are provided. | 2010-10-28 |
20100273191 | METHODS OF DIAGNOSING CANCER - A method of diagnosing cancer or a pre-malignant lesion is disclosed. The method comprises determining a level of CD24 expressed on peripheral blood cells of a subject in need thereof, wherein the level of CD24 above a predetermined threshold is indicative of the cancer or the pre-malignant lesion. | 2010-10-28 |
20100273192 | METHOD FOR DETECTION OF DISEASE HAVING INSULIN-RESISTANT CONDITIONS - Disclosed is a simple method for detecting a pathological condition of an insulin-resistant disease, particularly type-2 diabetes. The method comprises quantifying the ganglioside GM3 in a blood sample separated from a living body. More specifically, the method comprises the following steps (a) to (c): (a) separating a plasma or serum from the blood collected from a human; (b) quantifying the ganglioside GM3 in the plasma or serum; and (c) comparing the quantified ganglioside GM3 level to the mean ganglioside GM3 level determined in blood samples from healthy volunteers. | 2010-10-28 |
20100273193 | Triacetone Triperoxide and Diacetone Diperoxide Derivatives, Method for the Preparation and Use Thereof - This disclosure is drawn to a triacetone triperoxide derivative in accordance with the general formula (I) and a diacetone diperoxide derivative in accordance with the general formula (II) | 2010-10-28 |
20100273194 | IMMUNOREACTIVE EHRLICHIA P120/P140 EPITOPES AND USES THEREOF - Provided herein are immunoreactive peptides which can selectively bind | 2010-10-28 |
20100273195 | SKIN AGING-PREVENTING OR IMPROVING AGENT - The present invention provides a skin aging-preventing or improving agent. The agent contains a substance capable of enhancing the expression level of Rho kinase or myosin light-chain kinase. According to the present invention, aging of the skin such as sagging of the skin, wrinkle formation, or loss of skin elasticity can be prevented or the skin can be improved. | 2010-10-28 |
20100273196 | System and Method for Evaluating Blood-Neural Barrier Permeability - A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A | 2010-10-28 |
20100273197 | SMART ENZYME-CONTAINING CATALYTIC PEELABLE COATINGS - A coating material that is applied to a surface for absorbing a toxic chemical and that is removable from the surface by the use of mechanical force is disclosed. The coating material comprises one or more polymer coatings, one or more purified enzymes immobilized or entrapped in the polymer coating for protecting a surface from contamination by one or more toxic chemicals, one or more reporter indicators that are responsive to changes in pH in the presence of the toxic chemical for detecting and disclosing the location of said toxic chemical, and one or more buffers for establishing and/or maintaining the pH of the coating ranging from 5 to 10. Preferably, the reporter indicator is one or more pH-sensitive dyes or dye blends that change colors in the presence of the toxic chemical. A method for absorbing, detoxifying, detecting and disclosing of a toxic chemical is provided. | 2010-10-28 |
20100273198 | ENGINEERING ENZYMATICALLY SUSCEPTIBLE PROTEINS - The invention provides a synthetic phytase polypeptide which encodes an enzymatically susceptible phytase. Also provided are feed or food products comprising an enzymatically susceptible phytase, and transgenic plants which express the enzymatically susceptible phytase. Further provided are methods for making and using enzymatically susceptible phytases, e.g., a method of using an enzymatically susceptible phytase in feed and food processing. | 2010-10-28 |
20100273199 | Methods and Compositions - The invention relates to a method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: the structural composition of a polypeptide comprised by said sample; a metabolite comprised by said sample; and a catalytic activity comprised by said sample, wherein each of said at least two characteristics is determined from a multiplexed analysis of the same sample. The invention also relates to certain compositions. | 2010-10-28 |
20100273200 | In-Vitro Model of Blood-Brain Barrier, In-Vitro Model of Diseased Blood-Brain Barrier, and Drug Screening Method, Analysis Method for Functions of Diseased Blood-Brain Barrier, and Analysis Method for Pathogenesis Using the Same - It is intended to provide a screening system for a centrally acting drug transported across the blood-brain barrier, a drug acting on the blood-brain barrier itself, or a drug transferred into the brain without being expected to centrally act. Moreover, another object of the present invention is to achieve pathogenesis analysis study or the screening in a diseased state by applying various diseased environments to this screening system. The present invention provides an in-vitro model of blood-brain barrier obtained by using a three-dimensional culture apparatus comprising: a culture solution; a plate holding the culture solution; and a filter immersed in the culture solution and placed in no contact with the inside bottom of the plate, the filter having plural pores of 0.35 to 0.45 μm in diameter, and by comprising: seeding primary cultured brain capillary endothelial cells onto the upper surface of the filter; seeding primary cultured brain pericytes onto the under surface of the filter; seeding primary cultured astrocytes onto the inside surface of the plate; and coculturing these cells in a normal culture solution. | 2010-10-28 |
20100273201 | Acetolactate Synthase (ALS) Selectable Marker from Trichoderma reesei - A nucleic acid encoding an acetolactate synthase (ALS) protein that provides resistance to ALS inhibitors, e.g., sulphonylurea and imidazolinone compounds, is provided. The nucleic acid may be used as a selectable marker for expression of a protein of interest in host cells. | 2010-10-28 |
20100273202 | CODON-OPTIMIZED NUCLEIC ACID FOR CODING APO-CLYTIN-II AND METHOD FOR USING THE SAME - A codon-optimization of nucleic acid for coding apo-clytin-II protein is provided. Luminescent activity of clytin-II is remarkably enhanced. Accordingly, compared with the conventional use of the wild-type clytin-II, an intracellular calcium ion can be detected much more easily. | 2010-10-28 |
20100273203 | METHODS AND COMPOSITIONS FOR DETECTING METABOLITES - The present invention provides a metabolic profile, a database comprising a metabolic profile, a method for determining a metabolic profile, uses for a metabolic profile, and warfarin metabolites. | 2010-10-28 |
20100273204 | METHODS FOR MONITORING THE EFFICACY OF ANTI-IL-2R ANTIBODIES IN MULTIPLE SCLEROSIS PATIENTS - The use of HLA-DR | 2010-10-28 |
20100273205 | Magnetic resonance imaging contrast agents - This invention relates to novel magnetic resonance imaging contrast agents, and methods of making and use thereof. | 2010-10-28 |
20100273206 | DIAGNOSTIC IN VITRO METHOD FOR ASSESSING VON WILLEBRAND DISEASE AND INCREASED BLEEDING RISK ASSOCIATED WITH VON WILLEBRAND DISEASE AND ACQUIRED OR CONGENITAL DISORDERS OF PLATELET FUNCTION - The invention relates to an in-vitro method for diagnosing Von Willebrand Disease (VWD) and an increased bleeding risk associated with Von Willebrand Disease and/or acquired or congenital platelet function defects that reduce the interactions of Von Willebrand Factor (VWF) with platelets. The in-vitro method of the invention may also be used to diagnose further bleeding risks. The test is suitable for use as a screening test based on whole blood and has the additional benefit of being suitable as a point of care test. The method involves the incubation of a sample containing platelets and hemostasis factors with an activator of platelet aggregation and the measurement of the viscoelastic change after inducing coagulation, e.g., by means of thromboelastography (TEG). | 2010-10-28 |
20100273207 | Methods for Diagnosis of Sepsis and Risk of Death - The present invention is directed to methods for diagnosis of sepsis and high risk of sepsis death. Such methods are directed to subjects presenting to healthcare facilities with symptoms for sepsis. Clinico-metabolomic classifiers are tested and compared in the methods of the present invention. | 2010-10-28 |
20100273208 | MICROORGANISM TESTING APPARATUS - To eliminate the necessity of a dedicated optical system and the flowing of fluorescent microparticles for aligning excitation light with a flat plate-shaped flow cell which internally includes a flow path, a microorganism testing apparatus includes: a first detector that detects fluorescence emitted from microorganisms flowing through a detection flow path when a microorganism detection unit included in a microorganism testing chip is irradiated with excitation light, and converts the fluorescence to an electrical signal; and a second detector that detects scattered light similarly emitted from the microorganisms flowing through the detection flow path, and converts the scattered light to an electrical signal. The alignment of the detection flow path is performed in the direction of the optical axis of the excitation light by controlling and moving a stage having the microorganism testing chip mounted thereon based on the intensity of fluorescence detected by the first detector. | 2010-10-28 |
20100273209 | CO2 OPTICAL SENSOR FOR DETECTION AND ENUMERATION OF MICROORGANISMS - A new device and method for detecting the presence of living microorganisms in test samples are described. The device includes a container having at least one section transparent to light with an incubation zone defined in the container, the incubation zone containing growth media in which the sample is cultured. A detection zone containing a matrix composed of a polymeric material which is substantially transparent to light, and at least one indicator reagent sensitive to carbon dioxide gas generated by the microorganisms in the incubation zone is located in the transparent section of the matrix. The matrix is configured to facilitate penetration of external light aimed at the transparent section of the container and interaction of the external light with the indicator reagent to yield interactive light that escapes through the transparent section of the container, said interactive light is being indicative of the presence and/or concentration of the microorganisms. | 2010-10-28 |
20100273210 | Biofuel manufacturing methods and systems incorporating radiocarbon analysis techniques - The systems and methods described herein are directed toward the use of radiocarbon analysis techniques in the manufacture of biofuel products. Among other things, methods and systems for using measured fossil-fuel-derived carbon content in biofuel products to guide the design and modification of biofuel manufacturing systems are disclosed. | 2010-10-28 |
20100273211 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy - Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates to the construction, expression, purification, and use of synthetic or recombinant botulinum neurotoxin genes. For example, a synthetic gene for the LC of the botulinum neurotoxin serotype A (BoNT/A) was constructed and overexpressed in | 2010-10-28 |
20100273212 | PP1 Ligands - The invention relates to phosphatase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate PP1 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands. | 2010-10-28 |
20100273213 | METHOD FOR EXPRESSION OF SPECIFIC GENE - Disclosed is a cell which can express a non-natural oligomeric protein, which has, introduced therein, a gene encoding an exogenous polypeptide corresponding to at least one endogenous polypeptide constituting a natural oligomeric protein, and in which the expression of the endogenous polypeptide is inhibited. | 2010-10-28 |
20100273214 | POLYPEPTIDES HAVING ALPHA-GLUCURONIDASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2010-10-28 |
20100273215 | Secretion Yield of a Protein of Interest by in vivo Proteolytic Processing of a Multimeric Precursor - The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The invention further relates to a cell comprising this nucleic acid molecule and a method for producing a protein of interest using this cell. | 2010-10-28 |
20100273216 | METHODS FOR PROTEIN REFOLDING - Provided herein are methods for refolding proteins. The methods involve covalently modifying a denatured protein with a nonproteinaceous polymer and then renaturing the modified protein. | 2010-10-28 |
20100273217 | BIOCABURANT PREPARATION USING PENCILLIUM FUNICULOSUM ENZYMES - The present invention deals with a method for treating biomass comprising the steps of providing an enzyme mixture obtained from Penicillium funiculosum deposited under Budapest treaty in the International Mycological Institute under the number IMI 378536, providing plant biomass then contacting the enzyme mixture of step (a) and the biomass of step (b) under conditions wherein the saccharification of the biomass occurs. | 2010-10-28 |
20100273218 | COMPOSITIONS AND METHOD FOR STORAGE OF NUCLEIC ACID FROM BODILY FLUIDS - The present invention provides an aqueous composition comprising SDS, Cyclohexanediamine tetraacetate, Tris-HCl and proteinase K for the extraction of nucleic acid from a sample of bodily fluid, such a saliva, wherein the extracted nucleic acid is stable for at least fourteen days at room temperature The composition permits direct use of the extracted and stored DNA in an amplification reaction without further processing. | 2010-10-28 |
20100273219 | MULTI-PRIMER AMPLIFICATION METHOD FOR BARCODING OF TARGET NUCLEIC ACIDS - In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines. | 2010-10-28 |
20100273220 | INNATE IMMUNE SUPPRESSION ENABLES REPEATED DELIVERY OF LONG RNA MOLECULES - The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts. | 2010-10-28 |
20100273221 | METHOD FOR PRODUCING BASIC SUBSTANCE - A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process. | 2010-10-28 |
20100273222 | CORYNEBACTERIUM GLUTAMICUM ENHANCED EXPRESSION OF MOAA GENE ENCODING MOLYBDENUM COFACTOR BIOSYNTHESIS ENZYME A AND METHOD FOR PRODUCING L-LYSINE USING THE SAME - The present invention relates to a microorganism of | 2010-10-28 |
20100273223 | New Calb Muteins and Their Use - A protein having acrylation activity having a polypeptide sequence derived from SEQ ID NO: 1 or NO:2 by introducing at least one of the following amino acid substitutions: L278A, L278V, W104F, T42A, S47A. | 2010-10-28 |
20100273224 | PRODUCTION OF LACTIC ACID BY WAY OF FERMENTATION AND EXTRACTION OF AMINES - The invention relates to a process for the production and isolation of lactic acid which is produced by way of fermentation of a carbohydrate-bearing feedstock and the addition of ammonia. The lactic acid is released from the ammonium salt of the lactate by adding a mineral acid and the lactic acid isolation takes place by extraction with the aid of an alkylated amine. The extraction is preferably operated at a pH value of 4.0 to 2.0, thereby obtaining a multi-phase mixture which is split up. The phase thus obtained with the lactate salt of amine subsequently undergoes distillation, so that lactic acid is obtained as pure product or the phase with the lactate salt of amine are thermally decomposed, thereby producing an oligolactide that is distillable and thus yields a pure dilactide. The invention also encompasses a device suitable for the performance of the inventive process. | 2010-10-28 |
20100273225 | EXPRESSION CASSETTE FOR LACTASE DEHYDROGENASE, TRANSFORMED YEAST AND METHOD OF PRODUCING LACTIC ACID - A gene expressing cassette codes lactate dehydrogenase that is needed for prevention of deterioration in lactic acid yield and lactic acid production rate in continuous culture with simultaneous filtration of a yeast strain having a lactic acid-producing ability, which achieves high optical purity, high lactic acid yield and high lactic acid production rate simultaneously, a yeast strain having the cassette and a method of producing lactic acid by culturing the yeast strain. The lactate dehydrogenase-expressing cassette is a lactate dehydrogenase-expressing cassette, comprising a gene coding lactate dehydrogenase connected to a site downstream of a promoter, the promoter being a promoter of a gene showing a gene expression amount larger by 5 times or more than the average relative expression amount of all genes after 50 hours from start of culture in continuous culture with simultaneous filtration of a yeast strain having a lactic acid-producing ability. | 2010-10-28 |
20100273226 | ISOLATED POLYNUCLEOTIDE FOR INCREASING ALCOHOL TOLERANCE OF HOST CELL, VECTOR AND HOST CELL CONTAINING THE SAME, AND METHOD OF PRODUCING ALCOHOL USING THE SAME - Provided herein is an isolated polynucleotide for increasing the alcohol tolerance of a host cell. Also disclosed herein are a vector and a host cell containing the isolated polynucleotide, and a method of increasing the volumetric productivity of a bioalcohol using the same. | 2010-10-28 |
20100273227 | Detoxifying Pre-Treated Lignocellulose-Containing Materials - The invention relates to a process of detoxifying pre-treated lignocellulose-containing material comprising subjecting the pre-treated lignocellulose-containing material to one or more phenolic compound oxidizing enzymes. | 2010-10-28 |
20100273228 | PROCESS FOR PRODUCING ETHANOL FROM A HYDROLYSATE OF THE HEMICELLULOSE FRACTION OF SUGARCANE BAGASSE IN A PRESS REACTOR - The invention is a process for producing ethanol from sugarcane bagasse, the principal steps of which are mild sulphuric acid hydrolysis of the hemicellulose fraction of the sugarcane bagasse, followed by extraction of the hydrolysate and then fermentation thereof with the yeast | 2010-10-28 |
20100273229 | PROCESS FOR PRODUCING ETHANOL - A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid into ethanol using esterification and hydrogenation reactions. Coproducts can include corn oil, and high protein animal feed containing the biomass produced in the fermentation. | 2010-10-28 |
20100273230 | HIGH GRADIENT MAGNETIC SEPARATION OF BIOLOGICAL MATERIAL - The invention relates to a high gradient magnet separation device for the separation or purification of magnetic or magnetically labeled biological material, comprising a magnet, a separating column, and a ferromagnetic matrix that can be arranged in an interior chamber of the separating column, and a storage container containing a buffer solution for the equilibration of the separating column and/or for the suspension of the biological material, wherein during operation a magnetic field created by the magnet creates a high gradient magnetic filed in the matrix and buffer solution can flow from the storage container through the separating column. For this purpose, the buffer solution comprises a base solution and macromolecules that can saturate nonspecific binding sites of the matrix. | 2010-10-28 |
20100273231 | Multipotent mesenchymal stem cells from human hair follicles - The present invention is directed to an enriched preparation of multipotent mesenchymal cells obtained from human hair follicle stem cells, preferably adult human hair follicle cells. These cells can be differentiated into adipogenic, chondrogenic and osteogenic cells as well as smooth muscle cells. The present invention is also directed to a method of producing a tissue-engineered vascular vessel containing the preparation of isolated smooth muscle cells or progenitors thereof. The resulting tissue-engineered vascular vessel and a method of producing a tissue-engineered vascular vessel for a particular patient are also disclosed. | 2010-10-28 |
20100273232 | METHODS FOR CLONING SMALL RNA SPECIES - This invention pertains to methods for cloning microRNA (miRNA) and other small ribonucleic acid (RNA) species from relevant cell sources. | 2010-10-28 |
20100273233 | AMYLOID SPECIFIC PEPTIDES AND USES THEREOF - Phage peptide display technology was used to identify peptides that bind specifically to the amyloid form of the Aβ | 2010-10-28 |
20100273234 | PROCESS FOR OBTAINING BIOACTIVE RECOMBINANT PROTEIN FROM INCLUSION BODIES - This invention provides a process for obtaining bioactive recombinant protein from inclusion bodies without unfolding it completely into random coil structure. The process comprises solubilization of inclusion body protein using urea and propanol. | 2010-10-28 |
20100273235 | STABILIZED AQUEOUS ALPHA-GALACTOSIDASE COMPOSITION AND METHODS RELATING THERETO - The present invention provides an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase. The present invention further provides a method of stabilizing an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase, and a method of preparing a purified aqueous composition comprising the protein with enzymatic activity of alpha-galactosidase. | 2010-10-28 |
20100273236 | RECOMBINANT HOST FOR PRODUCING L-ASPARAGINASE II - The invention provides a recombinant | 2010-10-28 |
20100273237 | Processes for Packaging Oligonucleotides Into Virus-Like Particles of RNA Bacteriophages - The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before. The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof. The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%. | 2010-10-28 |
20100273238 | Cellular Permissivity Factor for Viruses and Uses Thereof - The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus. | 2010-10-28 |
20100273239 | LACTOBACILLUS HELVETICUS BACTERIUM COMPOSITION FOR TREATMENT OF ATOPIC DERMATITIS | 2010-10-28 |