METHOD OF JUDGING RISK FOR ONSET OF DRUG-INDUCED GRANULOCYTOPENIA

Abstract

presence of the risk of drug-induced granulocytopenia in a human is provided. A method for assessing the risk of drug-induced granulocytopenia, including detecting a polymorphism of the human insulin receptor substrate-2 gene of a subject, and determining the presence of the risk of drug-induced granulocytopenia of the subject by use of the genetic polymorphism as an index.

Description

TECHNICAL FIELD

[0001]The present invention relates to a method for assessing the risk of drug-induced granulocytopenia by use, as an index, of a polymorphism of the human insulin receptor substrate-2 gene; to a method of detecting the genetic polymorphism employed as an index for the aforementioned risk assessment; to oligonucleotides employed for these methods; and to a kit for the assessment and/or the detection.

BACKGROUND ART

[0002]The mainstay of modern medicine is drug therapy, which employs drugs for treating or preventing various diseases. Almost all drugs employed in drug therapy (e.g., low-molecular-weight compounds) intrinsically are foreign substances to the human body, and thus administration of such drugs provides therapeutic efficacy, but may cause a variety of side effects. Such side effects often compel the drug therapy to be abandoned. Also, some drugs have encountered a situation where research and development have to be suspended due to severe side effects, although the drugs have been proved to be useful for patients with a certain disease. Moreover, the use of some other drugs is strictly regulated in order to detect the sign of their side effects by mandatory examinations.

[0003]According to the statistics published in the United States, the cases of drug-induced side effects account for two millions or more a year, and more than 100 thousand due to such side effects (JAMA, 279, 1200 (1998)). In Japan, 26,545 cases of drug-induced side effects (including redundantly reported cases) were reported, and 1,239 deaths due to such side effects only in one year of 2000 (Ministry of Health, Labor and Welfare, Jun. 6, 2003, House of Representatives, Responsive Pleading No. 55).

[0004]Among side effects due to drug administration, granulocytopenia is a fatal side effect. Particularly, a decrease in granulocytes tends to lead to an infection, and onset of agranulocytosis involves a very high risk for a serious infectious disease such as pneumonia or sepsis. Examples of drugs that are generally known to induce granulocytopenia include analgesic-antipyretic drugs (aminopyrine), antibiotics (Chloromycetin), antithyroid drugs (Mercazole), anticonvulsant drugs, antidiabetic drugs, and diuretic drugs. Occurrence of side effects caused by such a drug is less likely to be related to its dose, and is considered to be related to the predisposition of a patient (e.g., allergic predisposition or idiosyncrasy). Therefore, occurrence of such side effects is almost impossible to predict. In order to avoid occurrence of such side effects, doctors must handle respective cases very carefully, through detailed interviews with individual patients regarding, for example, drug administration records in other departments, and analysis of blood test results, etc. Notably, if and when a patient has onset a side effect of granulocytopenia, doctors must take immediate measures, including hospitalization.

[0005]Other drugs that are known to induce granulocytopenia include dibenzodiazepine (clozapine), which is an antipsychotic drug. This drug is expected to have high efficacy, but clinical trials of the drug have been suspended in Japan.

[0006]Other drugs that induce granulocytopenia include vesnarinone, which has inhibitory activities on PDE3 and K channel. This drug is an effective inotropic drug that is less likely to cause arrhythmia and other cardiac events (e.g., onset of heart failure and hospitalization). However, administration of this drug may cause side effects; i.e., leukopenia, granulocytopenia, and subsequent agranulocytosis. Therefore, the use of this drug is strictly limited.

[0007]Single nucleotide polymorphisms (SNPs) are the most frequently used genetic markers in human genetic analysis. SNPs have already been shown to be useful markers for an association study between genetic background and common diseases or drug response (see Non-Patent Documents 1, 2, and 3). As has been known, analysis of haplotype, constructed of multiple SNPs, is useful for analysis of the susceptibility of polygenic diseases (see Non-Patent Documents 4 and 5). In practice, some diseases such as Alzheimer's disease and hypertension have already been intensively analyzed by such an analysis method (Jeunemaitre, X., et al., Am. J. Hum. Genet., 60, 1448-1460 (1997); Martin, E. R., Am. J. Hum. Genet., 67, 383-394 (2000)).

[0008]In recent years, advances in genome analysis have led to development of toxicogenomics, which studies relationship between genes and toxicities such as the effect of a drug on cytochrome P450 (CYP) (i.e., a drug-metabolizing enzyme). Particularly, association studies of individual genetic background and sensitivity/response has been proposed as a powerful tool to elucidate the cause of adverse effects. So-called tailor-made therapy is expected to be realized through these approaches

[0009]Non-Patent Document 1: Brookes, A. J., "The essence of SNPs," Gene, USA, (1999), 234, 177-186

[0010]Non-Patent Document 2: Cargill, M, et al., "Characterization of single-nucleotide polymorphisms in coding regions of human genes," Nature Genet., USA, (1999), 22, 231-238

[0011]Non-Patent Document 3: Evans, W. E., & Relling, M. V., "Pharmacogenomics: translating functional genomics into rational therapeutics," Science, USA, (1999), 286, 487-491

[0012]Non-Patent Document 4: Stephens, J. C., et al., "Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes," Am. J. Hum. Genet., USA, (1998), 62, 1507-1515

[0013]Non-Patent Document 5: Tishkoff, S. A., et al., "The accuracy of statistical methods for estimation of haplotype frequencies: an example from the CD4 locus," Am. J. Hum. Genet., USA, (2000), 67, 518-522

DISCLOSURE OF THE INVENTION

Problems to be Solved by the Invention

[0014]A primary object of the present invention is to provide means for assessing the risk of drug-induced granulocytopenia by use, as an index, of polymorphisms of the human insulin receptor substrate-2 gene, or means for detecting the genetic polymorphisms employed as an index for the risk assessment means.

Means for Solving the Problems

[0015]In order to solve the aforementioned problems, firstly, the present inventors have selected, as genes for polymorphism analysis, 115 candidate genes, including cytokine-related genes, MHC region genes, G-CSF-related genes, TNF-α-related genes, NFκ-related genes, cAMP-related genes, and K-channel-related genes, searched for SNPs in these candidate genes from the database of Japanese Single Nucleotide Polymorphisms, and picked up 188 candidate SNPs for analysis.

[0016]Subsequently, the present inventors have determined the frequency of these SNPs in the genomic DNA of samples from the following two groups: a group of subjects with granulocytopenia induced by administration of a specific drug, and a group of subjects without granulocytopenia who have received the same drug. As a result, the present inventors have confirmed that SNPs with the most statistically significant difference between the aforementioned two groups are present on the insulin receptor substrate-2 gene (J-SNP ID: IMS-JST040476) (hereinafter, the gene will be referred to as "the IRS-2 gene").

[0017]Furthermore, the present inventors have conducted extensive studies on the relationship between polymorphisms in the human IRS-2 gene and drug-induced granulocytopenia, and as a result have confirmed that six SNPs of the human IRS-2 gene are intimately related to granulocytopenia induced by administration of the drug.

[0018]The present inventors have found that analysis of these specified SNPs enables assessment (predictive diagnosis) of the risk of side effects induced by drugs for various human diseases; particularly, the risk of onset of drug-induced granulocytopenia. The present invention has been accomplished on the basis of this finding.

[0019]The present invention provides a method for determining the presence of the risk of drug-induced granulocytopenia, a method of detecting a genetic polymorphism markers employed as an index for the aforementioned risk determination, and oligonucleotides and kit employed for these methods, which are summarized below in (1) through (19).

[0020](1) A method for assessing the risk of drug-induced granulocytopenia, the method comprising detecting polymorphisms of the human IRS-2 gene of a subject, and determining the presence of the risk of drug-induced granulocytopenia of the subject by use of the genetic polymorphisms as an index.

[0021](2) A method of detecting polymorphisms of the human IRS-2 gene of a subject for determining the presence of the risk of drug-induced granulocytopenia, in which the genetic polymorphism is employed as an index.

[0022](3) An examination method for the risk of drug-induced granulocytopenia, comprising detecting a polymorphism of the human IRS-2 gene of a subject, and carrying out an examination using the genetic polymorphisms as an index for the risk.

[0023](4) A method as described in any of (1) through (3) above, wherein the presence of the risk of drug-induced granulocytopenia is determined by use, as an index, of at least one genetic polymorphism selected from the group consisting of human IRS-2 gene polymorphisms described below in (a) through (f):

(a) a polymorphism that is C (wild type) to A conversion at position 4,587 upstream of the translation initiation codon;(b) a polymorphism that is AT deletion (wild type) at position 2,510 upstream of the translation initiation codon;(c) a polymorphism that is A (wild type) to C conversion at position 1,164 upstream of the translation initiation codon;(d) a polymorphism that is A (wild type) to G conversion at position 15,870 downstream from the translation initiation codon;(e) a polymorphism that is A (wild type) to G conversion at position 29,793 downstream from the translation initiation codon; and(f) a polymorphism that it C deletion (wild type) at position 31,532 downstream from the translation initiation codon.

[0024](5) A method as described in any of (1) through (4) above, wherein the genetic polymorphisms is detected through at least one technique selected from the group consisting of direct nucleotide sequencing, allele-specific oligonucleotide (ASO)-dot blot analysis, single nucleotide primer extension assay, PCR-single strand conformation polymorphism (SSCP) analysis, PCR-restriction enzyme fragment length polymorphism (RFLP) analysis, Invader assay, quantitative real-time PCR assay, and genetic polymorphism assay employing a mass spectrometer (mass array).

[0025](6) A method as described in (5) above, wherein the genetic polymorphisms is detected through direct nucleotide sequencing.

[0026](7) A method as described in (5) above, wherein the genetic polymorphisms are detected through PCR-restriction enzyme fragment length polymorphism (RFLP) analysis.

[0027](8) A method as described in (7) above, wherein the PCR-restriction enzyme fragment length polymorphism (RFLP) analysis is performed by use of the restriction enzyme Afa I for detecting A to G conversion at position 29,793 downstream from the translation initiation codon of the human IRS-2 gene.

[0028](9) An oligonucleotide which can be hybridized with the human IRS-2 gene and is employed as a primer or probe for genetic polymorphism detection, the oligonucleotide being selected from the group consisting of oligonucleotides described below in (a) through (f):

(a) an oligonucleotide having a sequence including a genetic polymorphism that is C to A conversion at position 4,587 upstream of the translation initiation codon of the human IRS-2 gene;(b) an oligonucleotide having a sequence including a genetic polymorphism that is AT deletion at position 2,510 upstream of the translation initiation codon of the human IRS-2 gene;(c) an oligonucleotide having a sequence including a genetic polymorphism that is A to C conversion at position 1,164 upstream of the translation initiation codon of the human IRS-2 gene;(d) an oligonucleotide having a sequence including a genetic polymorphism that is A to G conversion at position 15,870 downstream from the translation initiation codon of the human IRS-2 gene;(e) an oligonucleotide having a sequence including a genetic polymorphism site that is A to G conversion at position 29,793 downstream from the translation initiation codon of the human IRS-2 gene; and(f) an oligonucleotide having a sequence including a genetic polymorphism that is C deletion at position 31,532 downstream from the translation initiation codon of the human IRS-2 gene.

[0029](10) An oligonucleotide, which can be hybridized with the human IRS-2 gene is employed as a primer for genetic polymorphism detection, the oligonucleotide being selected from the group consisting of oligonucleotides described below in (a) through (d) and (f):

(a) an oligonucleotide having the sequence of SEQ ID NO: 3;(b) an oligonucleotide having the sequence of SEQ ID NO: 6;(c) an oligonucleotide having the sequence of SEQ ID NO: 9;(d) an oligonucleotide having the sequence of SEQ ID NO: 12; and(f) an oligonucleotide having the sequence of SEQ ID NO: 17.

[0030](11) A kit for assessing the risk of drug-induced granulocytopenia, the kit comprising an oligonucleotide as described in (9) above serving as a primer or probe for detecting a polymorphism of the human IRS-2 gene.

[0031](12) A kit as described in (11) above, which comprises oligonucleotides as described in (10) above.

[0032](13) A kit as described in (11) above, which comprises the oligonucleotide as described in (e) of (9) above and the restriction enzyme Afa I, the kit being employed for detecting A to G conversion at position 29,793 downstream from the translation initiation codon of the human IRS-2 gene.

[0033](14) A method as described in (1) above, which assesses the risk of drug-induced granulocytopenia attributed to vesnarinone administration by use of oligonucleotides as described in (9) or (10) above.

[0034](15) A method as described in (1) above, which assesses the risk of drug-induced granulocytopenia attributed to vesnarinone administration by use of the oligonucleotides as described in (e) of (9) above and the restriction enzyme Afa I.

[0035](16) A kit for detecting a polymorphism of the human IRS-2 gene employed for determining the presence of the risk of drug-induced granulocytopenia, the kit comprising oligonucleotides as described in (9) above as primers or probes for detecting the IRS-2 gene polymorphisms.

[0036](17) A kit as described in (16) above, which comprises oligonucleotides as described in (10) above.

[0037](18) A kit as described in (16) above, which comprises the oligonucleotides as described in (e) of (9) above and the restriction enzyme Afa I, the kit being employed for detecting A to G conversion at position 29,793 downstream from the translation initiation codon of the human IRS-2 gene.

[0038](19) A method as described in (2) above, which detects a genetic polymorphism employed for assessing the risk of drug-induced granulocytopenia attributed to vesnarinone administration by use of oligonucleotides as described in (9) or (10) above.

[0039](20) A method as described in (2) above, which detects a genetic polymorphism employed for assessing the risk of drug-induced granulocytopenia attributed to vesnarinone administration by use of the oligonucleotides as described in (e) of (9) above and the restriction enzyme Afa I.

[0040](21) A method as described in (3) above, in which the examination is carried out concerning the risk of drug-induced granulocytopenia attributed to vesnarinone administration, by use of oligonucleotides as described in (9) or (10) above.

[0041](22) A method as described in (3) above, in which the examination is carried out concerning the risk of drug-induced granulocytopenia attributed to vesnarinone administration, by use of oligonucleotides as described in (e) of (9) above and the restriction enzyme Afa I.

EFFECTS OF THE INVENTION

[0042]According to the present invention, there are provided methods for assessing the risk of drug-induced granulocytopenia in a human; a method of detecting a genetic polymorphism employed as an index for the aforementioned assessment; kits for these methods; primers and probes for polymorphism detection, which are employed in these methods; and a gene relating to a risk factor for drug-induced granulocytopenia in a human. These are useful for examining or assessing the risk of human drug-induced granulocytopenia, particularly useful for examining or assessing the risk of human drug-induced granulocytopenia before administration of a drug which has already been reported to induce granulocytopenia (including agranulocytosis).

BRIEF DESCRIPTION OF THE DRAWING

[0043]FIG. 1 A schematic representation showing the structure of the human IRS-2 gene and the positions of polymorphisms of the gene.

BEST MODE FOR CARRYING OUT THE INVENTION

[0044]As used herein, abbreviations of amino acids, peptides, nucleotide sequences, nucleic acids, etc. are according to IUPAC-IUB nomenclature [IUPAC-IUB communication on Biological Nomenclature, Eur. J. Biochem., 138: 9 (1984)], "Guideline for preparation of a specification, etc. including nucleotide sequences or amino acid sequences" (edited by Japan Patent Office), and commonly employed symbols used in the field.

[0045]As used herein, the genomic sequence of the human IRS-2 (insulin receptor substrate 2) gene is included in the sequence reported by Mohammadi, M. at Sanger Center (GenBank Accession No: AL162497; version 20; SEQ ID NO: 18), which has a full length of 143,409 bp.

[0046]The IRS-2 gene, whose structure is estimated by the genomic sequence on the basis of the sequence data of IRS-2 mRNA sequence obtained from GenBank (accession number XM 007095) and the sequence data of the aforementioned AL162497, is a 32,730 bp composed of two exons and one intron. The IRS-2 gene corresponds to 93,673 to 126,402 by in the sequence of AL162497. FIG. 1 schematically shows the structure of the IRS-2 gene. In FIG. 1, "Ex. 1" and "Ex. 2" correspond to the aforementioned two exons. Abbreviations with arrows correspond to the below-described alterations (SNPs). Notably, the SNPs are synonymous; i.e., the SNPs do not cause amino acid substitutions, and therefore the protein sequence does not be changed. The position numbers of SNPs as described in the specification or the figure correspond to the position numbers counting from A of ATG that is used as a codon for Met at N-terminus of protein when mRNA is translated into protein (translation initiation codon).

[0047]C-4587A: C to A conversion at position 4,587 upstream of the translation initiation codon of the human IRS-2 gene;

[0048]AT-2510del: AT deletion at position 2,510 upstream of the translation initiation codon of the human IRS-2 gene;

[0049]A-1164C: A to C conversion at position 1,164 upstream of the translation initiation codon of the human IRS-2 gene;

[0050]A15870G: A to G conversion at position 15,870 downstream from the translation initiation codon of the human IRS-2 gene;

[0051]A29793G: A to G conversion at position 29,793 downstream from the translation initiation codon of the human IRS-2 gene; and

[0052]C31532del: C deletion at position 31,532 (in Ex. 2) from the translation initiation codon of the human IRS-2 gene.

[0053]As used herein, the term "gene" encompasses double-stranded DNA, as well as single-stranded DNA (sense strand or antisense strand) constituting the double-stranded DNA. Unless otherwise specified, the gene (DNA) employed in the present invention encompasses double-stranded DNA including human genomic DNA, single-stranded DNA including cDNA (sense strand), single-stranded DNA having a sequence complementary to the sense strand, and fragments thereof. The aforementioned gene (DNA) may include regulatory regions, coding regions, exons, and introns. The term "polynucleotide" encompasses RNA and DNA. The term "DNA" encompasses cDNA, genomic DNA, and synthetic DNA. The term "polypeptide" encompasses its fragments, homologues, derivatives, and mutants. The term "mutant" refers to a naturally occurring allele mutant, a non-naturally occurring mutant, a mutant obtained through alteration (deletion, substitution, addition, or insertion), and a polynucleotide sequence which does substantially not change the function of the polypeptide encoded by the polynucleotide sequence. Alteration of an amino acid sequence, which may naturally occur through, for example, mutation or post-translational modification, can be artificially performed by introducing mutations into the gene.

[0054]As used herein, the term "SNP (single nucleotide polymorphism)" refers to alteration of a single nucleotide in a gene or gene cluster, and "SNPs" refers to plural form of SNP. The term "haplotype" refers to the type of the aforementioned single strand marker constructed of multiple polymorphic sites of a continuous gene region or gene cluster.

[0055]The present invention has been accomplished on the basis of the finding that a polymorphism(s) including alteration at a specific site of the human IRS-2 gene (the entirety of the IRS-2 gene including the promoter region involved in transcriptional regulation), particularly, SNP or SNPs are intimately correlated with human drug-induced granulocytopenia, and the risk of drug-induced granulocytopenia can be assessed (pre-diagnosed) by detecting the SNPs as a genetic polymorphism marker at the specific site. The assessment method of the present invention involves detection of a polymorphism(s) (i.e., SNP or SNPs) of the human IRS-2 gene of a sample (derived from a subject).

[0056]The SNPs detected and analyzed by the method of the present invention (i.e., genetic alterations serving as an index for assessing the risk of drug-induced granulocytopenia) include the aforementioned six polymorphisms; i.e., C-4587A, AT-2510del, A-1164C, A15870G, A29793G, and C31532del. The positions of the SNPs on the IRS-2 gene are as shown in FIG. 1. Notably, the position numbers of the SNPs correspond to the position numbers counting from A of ATG that is used as a codon for Met at N-terminus of protein when mRNA is translated into protein (translation initiation codon).

[0057]The present invention enables detection of polymorphisms (SNPs and haplotype) of the human IRS-2 gene, which provides data or means useful for elucidation and understanding of the mechanism of drug-induced granulocytopenia in human, and for diagnosis and prevention of the disease. According to the present invention, when a subject having the risk of drug-induced granulocytopenia is determined, and administration of a drug to the subject is avoided, drug-induced granulocytopenia can be prevented. Moreover, when other assays are performed frequently in addition to the present invention to monitor side effects upon administration of a drug, effective measures can be taken against such side effects.

[0058]The method of the present invention will next be described in detail.

[0059]In the method of the present invention, polymorphisms of the human IRS-2 gene of a subject are detected, and the presence of the risk of drug-induced granulocytopenia is determined by use of the genetic polymorphisms as an index.

[0060]Detection of the polymorphisms of the human IRS-2 gene is performed through, for example, the following procedure: the genomic sequence of the human IRS-2 gene of a subject, or its complementary strand is prepared, and, if desired, the genomic sequence or the sequence of its complementary strand is determined, followed by detection of the gene polymorphisms.

[0061]Preparation of Human IRS-2 Gene Including SNPs

[0062]The human IRS-2 gene derived from a subject is prepared as a sample for DNA analysis. Specific examples of the gene having polymorphisms (SNPs) are as described above. The IRS-2 gene encompasses the above-exemplified complementary strand of the DNA sequence of the human IRS-2 gene.

[0063]The human IRS-2 gene, which has genetic polymorphisms, or its complementary strand can be readily prepared through a generally employed genetic engineering technique on the basis of specific sequence data of the human IRS-2 gene as disclosed herein [see, for example, Molecular Cloning 2nd Ed, Cold Spring Harbor Lab. Press (1989); or Zoku Seikagaku Jikken Koza "Idenshi Kenkyuho I, II, III" edited by The Japanese Biochemical Society (1986)].

[0064]Specifically, cDNA or genomic DNA is extracted, through a common method, from a subject (e.g., a patient with human drug-induced granulocytopenia who has SNPs of the human IRS-2 gene), and a target clone is selected through a common method employing, for example, an appropriate antibody, restriction enzyme, or probe which may include a specific polymorphism of the human IRS-2 gene [see, for example, Proc. Natl. Acad. Sci., U.S.A., 78, 6613 (1981); or Science, 222, 778 (1983)], to thereby prepare a target genomic sequence of the IRS-2 gene.

[0065]Examples of the source of the aforementioned cDNA or genomic DNA include various cells and tissues having the IRS-2 gene including SNPs, and cultured cells derived therefrom. Other examples of the source include body fluids such as blood (e.g., serum or plasma), saliva, lymph, airway mucus, urine, and semen. The aforementioned source material (serving as a sample) is preferably DNA or genomic DNA derived from a human subject before administration of a drug (in particular, a drug which has previously been reported to induce granulocytopenia). Isolation of RNA from such a source material, isolation and purification of mRNA, preparation of cDNA, cloning thereof, etc. can be carried out through a common method. In the present invention, various commercially available cDNA libraries (e.g., cDNA libraries available from Clontech Lab. Inc.) may be employed.

[0066]No particular limitation is imposed on the method for screening a target gene from cDNA libraries, and the gene screening can be performed through a common method. Specifically, there is a prepared probe including a polymorphic site which can selectively bind to the DNA sequence of target sequence around SNPs, and plaque hybridization, colony hybridization, etc. These methods are performed singly or in combination by use of the thus-prepared probe.

[0067]The primers employed for screening may be a forward primer or reverse primer designed on the basis of target nucleotide sequence data of the human IRS-2 gene. Such primers can be synthesized through a common method by use of, for example, an automated synthesis apparatus. The probe for screening is generally a labeled probe. However, the screening probe may be an unlabeled probe, so long as it can specifically bind to a directly or indirectly labeled reagent. The labeling reagent and labeling technique such a probe or ligand have already been well known in the field. Examples of the labeling reagent include radioactive labeling reagents, biotin, fluorescent dyes, chemiluminescent reagents, enzymes (e.g., luciferase), and antibodies, which can be incorporated through a known labeling technique such as nick translation, random priming, or kinase treatment.

[0068]The thus-extracted genomic DNA or mRNA including the human IRS-2 gene can be amplified through a gene amplification method. This gene amplification enables easier and accurate detection through the detection method of the present invention. Examples of the gene amplification method include PCR (Saiki, R. K., Bugawan, T. L., et al., Nature, 324, 163-166 (1986)), NASBA (Comptom, J., Nature, 650, 91-92 (1991)), TMA (Kacian, D. L., and Fultz, T. J., U.S. Pat. No. 5,399,491 (1995)), and SDA (Walker, G. T., Little, M. C., et al., Proc. Natl. Acad. Sci., U.S.A., 89, 392-396 (1992)).

[0069]Gene fragments amplified by means of, for example, PCR may be isolated and purified through a common technique such as gel electrophoresis. Alternatively, purification of such gene fragments may be performed by use of a column. The gene fragment purification can be confirmed through, for example, mass spectrometry. In accordance with properties of the thus-amplified gene fragments, the gene fragments are applied for detection of the human IRS-2 gene (SNPs) employed in the present invention.

[0070]Detection of Human IRS-2 Gene Polymorphism

[0071]In the method of the present invention, subsequently, the presence of a polymorphism (s) of the aforementioned sample is detected. Specifically, this detection can be performed through, for example, any of the below-described methods (1) through (8).

[0072](1) Direct Nucleotide Sequencing

[0073]Detection of the IRS-2 gene polymorphism (s) can be performed through a direct nucleotide sequencing method, which has conventionally been employed for sequencing of such a gene; for example, the dideoxy method (Sanger, et al., Proc. Natl. Acad. Sci., U.S.A., 74, 5463-5467 (1977)) or the Maxam-Gilbert method [Methods in Enzymology, 65, 499 (1980)]. The genetic polymorphism detection may be performed through a combination of such a direct nucleotide sequencing method and a DNA amplification method (e.g., PCR). Particularly, a combination of such a direct nucleotide sequencing method and PCR or a similar DNA amplification method is preferred, since this combination needs only a small amount of a DNA sample, and enables simple and easy detection with high sensitivity and accuracy.

[0074]Basically, this preferred method can be performed through, for example, the following procedure: a PCR-amplified gene fragment or a purified product thereof is cloned into a plasmid, followed by direct nucleotide sequencing through the dideoxy method, the Maxam-Gilbert method, or a similar method. For the sake of convenience, the preferred method can be performed through nucleotide sequencing by use of, for example, a commercially available sequencing kit. Thus, the presence of polymorphisms at the aforementioned specific sites of the human IRS-2 gene can be detected.

[0075]In the aforementioned method and the below-described methods, no particular limitation is imposed on the PCR-amplified DNA fragment (i.e., sample), so long as the DNA fragment includes at least one of the aforementioned specific sites at which polymorphisms is expected to occur. The DNA fragment generally has a length of about 50 to several thousands of bp, preferably 50 to several hundreds of bp.

[0076](2) Allele-Specific Oligonucleotide Dot Blot Method

[0077]Alternatively, detection of the IRS-2 gene polymorphism (s) can be performed through the allele-specific oligonucleotide (ASO)-dot blot method (Conner, B. J., et al., Proc. Natl. Acad. Sci., U.S.A., 80, 278-282 (1983)). This method can be performed through, for example, dot blot analysis in which a PCR-amplified gene fragment by use of a forward primer and reverse primer designed so as to sandwich a target is hybridized with an allele-specific oligonucleotide probe containing SNP site. Thus, the presence of SNP in the gene fragment can be determined.

[0078](3) Single Nucleotide Primer Extension Assay

[0079]Detection of the IRS-2 gene polymorphism(s) can also be performed through a single nucleotide extension assay, such as the SNaPshot assay, pyrosequencing, or the point mutation detection assay disclosed in Japanese Patent Application Laid-Open (kokai) No. 2000-279197. In such an assay, a probe designed so as to correspond to a nucleotide immediately (or several nucleotides) before a target polymorphism (SNP) (i.e., a probe designed such that the 3'-end thereof corresponds to one (or several) nucleotide upstream of the polymorphism) is annealed to a DNA sample. Each of the aforementioned assays can be performed by use of a commercially available SNPs detection kit and the software attached to the kit.

[0080]For example, the SNaPshot assay can be performed by use of ABI PRISM SNaPshot ddNTP Primer Extension Kit (PE Applied Biosystems). Detection of SNPs can be performed through detection and analysis of fluorescent fragments generated after reaction by use of ABI PRISM 310/377/3100/3700 DNA Analyzer (PE Applied Biosystems) and GeneScan software.

[0081]Pyrosequencing can be performed through, for example, the following procedure. Specifically, genomic DNA is isolated from, for example, a blood sample through a common method; several tens to several hundreds of nucleotides (including a polymorphism) are PCR-amplified by use of a biotin-labeled primer; single-stranded DNA is purified by use of magnet beads; and the thus-purified DNA is employed as a sample. A primer designed to have a complementary sequence corresponding to several nucleotides upstream of a target polymorphism is annealed to the sample, and then each dNTP is added to the mixture none after another according to the sequence in the vicinity of the polymorphism input in software. Pyrophosphoric acid (PPi) released from nucleotide extension of DNA polymerase is converted to ATP by ATP sulfurylase, and luciferase generates detectable light using this ATP, which can be detected with a chemiluminescence detector, a CCD camera, etc. Thus, genotyping can be performed through analysis of the peak of luminescence obtained through addition of the dNTPs. This method enables genotyping in about 15 minutes for 96 samples.

[0082]The aforementioned method can use a generally employed reagent and apparatus. Examples include reagents such as commercially available SNP Reagent Kits (Pyrosequencing AB) which contain, as components, a mixture of the following four enzymes: DNA polymerase, ATP-sulfurylase, luciferase, and apyrase, a substrate solution containing luciferin and APS (adenosine 5'-phosphosulfate), and dNTPs containing dATP (deoxyadenosine 5'-triphosphate), dCTP, dGTP, and dTTP; PSQ96 system for automatic DNA sequence analysis (Pyrosequencing AB); and SNP software employed for the analysis (Pyrosequencing AB).

[0083]Alternatively, pyrosequencing can be performed through, for example, the method described in U.S. Pat. No. 6,159,693. Specifically, an isolated genomic DNA is amplified; the thus-amplified PCR product is purified; and the resultant product is reacted with pyrophosphoric acid by use of READIT® System (Promega Corporation), followed by analysis of the resultant data.

[0084](4) PCR-Single Strand Conformation Polymorphism (SSCP) Analysis

[0085]The detection method of the present invention can employ the PCR-SSCP method (Orita, M., Iwahara, H., et al., Proc. Natl. Acad. Sci., U.S.A., 86, 2776-2770 (1989)), in which an amplified PCR product (single-stranded DNA) is subjected to non-denatured polyacrylamide gel electrophoresis, and the presence of single nucleotide polymorphims is determined on the basis of the mobility difference.

[0086](5) PCR-Restriction Enzyme Fragment Length Polymorphism (RFLP) Analysis

[0087]In the present invention, in the case where, for example, a nucleotide sequence including a polymorphims, which are targeted for detection of SNPs or haplotype of the human IRS-2 gene, contains a restriction enzyme recognition site, the detection can be performed through restriction enzyme fragment length polymorphism analysis (RFLP analysis: Botstein, D. R., et al., Am. J. Hum. Gen., 32, 314-331 (1980)).

[0088]Specifically, for example, there is employed a restriction enzyme which can recognize nucleotides around the polymorphism, in order to detect whether the nucleotide at position 29,793 is A (wild type) or G (mutant type), the position being counted from the translation initiation codon present in Ex. 2 of the human IRS-2 gene. The enzyme employed in the RFLP analysis may be any known restriction enzyme, so long as the enzyme can recognize nucleotides around the target polymorphisms. Specific examples of the restriction enzyme include Afa I.

[0089]The RFLP analysis is more preferably done as PCR-RFLP analysis; i.e., analysis performed on a large amount of sample DNA which has been amplified and prepared in advance through PCR or a modification thereof. Thus, the presence of polymorphism can be detected on the basis of the presence of a specific cleavage site.

[0090]More specifically, detection of SNP of the human IRS-2 gene by the PCR-RFLP analysis is performed through, for example, the following procedure. Firstly, the genomic DNA of the human IRS-2 gene is extracted from a human biological sample, and a DNA fragment of the region including a polymorphism of the gene is amplified, thereby preparing a large amount of a DNA sample. The forward primer and/or reverse primer to be employed may be a primer whose sequence is not completely identical to the genomic sequence, as long as is a primer containing a sequence for introducing a restriction enzyme recognition site. Subsequently, the above-amplified DNA sample is digested by use of a specific restriction enzyme (i.e., an enzyme which can digest either a wild type or a mutant type), and DNA cleavage patterns (e.g., the presence of cleavage, or the base length of cleaved fragments) are confirmed through a common method such as gel electrophoresis.

[0091]In the case of the polymorphism (A29793G) of the human IRS-2 gene specified by the present invention, which is associated with human drug-induced granulocytopenia, a specific recognition site (GTAC) of the restriction enzyme Afa I is generated by the SNP in the region including positions 29,793 to 29,796 of the nucleotide sequence of the human IRS-2 gene. Therefore, this polymorphism can be detected through the RFLP analysis.

[0092](6) Invader Assay

[0093]Detection of SNPs of the IRS-2 gene can also be performed through the Invader assay. The Invader assay can be performed with reference to the following publications: [0094]Lyamichev, V., et al., Nat. Bio/technol., 17(3) 292-296 (1999); and [0095]International Patent Publication WO 9823774 (Japanese Kohyo Patent Publication No. 2001-526526).

[0096]The Invader assay enables analysis of SNPs of genomic DNA without amplification of target DNA. For example, the Invader assay is performed as follows.

[0097]In order to detect the presence of target SNPs of the human IRS-2 gene, firstly, genomic DNA is isolated. To perform this assay, two oligonucleotides were prepared by use of, for example, an automated DNA synthesis apparatus. One oligonucleotide, the allele-specific probe, contains the complementary base of the SNP nucleotide to be analyzed, and extends to the upstream of the SNP. Additional non-complementary nucleotides, which are composed of 15 to 50 nucleotides (5' flap), were added to this probe on its 5' site. The second oligonucleotide having 15 to several tens of nucleotides, the Invader oligonucleotide probe, has a complementary sequence to the downstream of the SNP and the end of the probe is a non-matching base overlapping the SNP nucleotide to be analyzed. The two oligonucleotides and an enzyme (i.e., Cleavase for the Invader assay employed in the present invention) are added to the target genomic DNA, which is extracted from described above. This enzyme recognizes the specific structure composed of the two oligonucleotides and the target genomic DNA. This reaction mixture is reacted under the appropriate conditions.

[0098]When the genomic DNA of a sample has a target SNP, a first reaction proceeds; the enzyme cleaves the 5' flap. On the other hand, when the genomic DNA of a sample does not have a target SNP, the enzyme does not cleave it.

[0099]The 5' flap released from the allele-specific probe which has been cleaved by the enzyme is complementarily bound to a fluorescence resonance energy transfer (FRET) probe serving as a target, and the 3'-end of the 5' flap is invaded in the FRET probe. In a manner similar to that described above, enzymatic reaction (second reaction) occurs, and a fluorescent dye is released.

[0100]The FRET probe employed in this second reaction is formed such that it doesn't depend on a target to be detected, and contains the following two essential elements:

[0101](1) a 3' region which is complementary to a product cleaved through the first reaction; and

[0102](2) a self-complementary region which forms a duplex for mimicking a single-stranded probe, which is hybridized with a target, and which contains a reporter fluorescent dye and a quencher fluorescent dye.

[0103]When the reporter fluorescent dye and the quencher fluorescent dye are bound to the same probe, the fluorescence intensity of the reporter fluorescent dye is quenched through fluorescence resonance energy transfer. Whereas when the reporter fluorescent dye and the quencher fluorescent dye are not bound to the same probe, the fluorescence intensity of the reporter fluorescent dye is not quenched. When the 5' flap released from the cleaved first probe is hybridized with the FRET probe, the resultant product acts as an invader oligonucleotide in the second reaction, and an invasion complex that is recognized by the enzyme is produced. Thus, cleavage of the FRET probe by the aforementioned enzyme separates the two fluorescent dyes, thereby yielding a detectable fluorescent signal. The signal can be read by use of, for example, a standard fluorescence microtiter plate reader, whereby the presence of target SNPs can be detected. A combination of the first and second reactions can amplify the signal by a factor of 1×10⁶. Employment of two FRET probes having different fluorescent dyes also enables detection of the presence of SNP.

[0104](7) Quantitative Real-Time PCR Assay

[0105]Detection of polymorphisms of the human IRS-2 gene can also be readily performed by quantitative real-time PCR assay (TaqMan assay).

[0106]This assay can be performed through, for example, the following procedure. Specifically, firstly, to confirm the presence of a polymorphism, a DNA fragment is prepared as a forward primer or reverse primer formed of, for example, 15 to 39 nucleotides. In this case, the forward primer or reverse primer is prepared so as not to contain the polymorphims. Subsequently, there is prepared a probe which has both a reporter fluorescent dye and a quencher fluorescent dye, and the probe contains, for example, a 15 to 50 by oligonucleotide which correspond to a partial sequence of amplified fragment. The nucleotide sequence of the probe has to be selected such that a region with which both of the forward and reverse primer do not hybridize. The probe is designed so as to have a sequence complementary to an allele-specific sequence for detecting the presence of a target single nucleotide polymorphism. By use of the probe, a target DNA fragment of the IRS-2 gene of a sample to be detected is amplified through PCR, and fluorescence from the resultant reaction mixture is real-time measured. Thus, the presence of polymorphism can be detected. Employment of two probes having different fluorescent dyes also enables detection of both alleles.

[0107]The reporter fluorescent dye employed in the aforementioned Invader assay or TaqMan assay is preferably a fluorescein fluorescent dye such as FAM (6-carboxy-fluorescein), whereas the quencher fluorescent dye is preferably a rhodamine fluorescent dye such as TAMRA (6-carboxy-tetramethyl-rhodamine). These fluorescent dyes are known, and are contained in commercially available real-time PCR detection kits. In the present invention, such a commercially available fluorescent dye can be employed. No particular limitation is imposed on the binding position of the reporter fluorescent dye or the quencher fluorescent dye, but generally, the reporter fluorescent dye is bound to one end (preferably the 5'-end) of the oligonucleotide constituting the probe, and the quencher fluorescent dye is bound to the other end. The method for binding a fluorescent dye to an oligonucleotide is known, and is described in, for example, Noble, et al., (1984), Nuc. Acids Res., 12: 3387-3403 or Iyer, et al., (1990), J. Am. Chem. Soc., 112: 1253-1254.

[0108]The TaqMan assay per se is known, and apparatuses and kits for the TaqMan assay are commercially available. In the present invention, such a commercially available apparatus or kit can be employed. For example, the TaqMan assay can be performed according to the method described in Japanese Patent No. 2,825,976, or according to the ABI PRISM 7700 sequencing system user manual (PE Applied Biosystems).

[0109](8) Genetic Polymorphism Assay Employing a Mass Spectrometer (Mass Array)

[0110]The mass array assay detects the difference in molecular weight between polymorphisms. Specifically, a region including a polymorphism to be detected is amplified through PCR, and then an extension primer is hybridized with a sequence immediately before the position of SNP, followed by extension reaction by use of a reaction mixture containing a ddNTP/dNTP mixture (e.g., a reaction mixture containing ddATP, dCTP, dGTP, and dTTP), thereby yielding a fragment having a length depending on the type of SNP. The resultant fragment is purified, and then subjected to analysis by use of, for example, a MALDI-TOF mass spectrometer, whereby the relationship between the molecular weight and the genetic polymorphism can be analyzed (Pusch, W., Wurmbach, J H., Thiele, H., Kostrzewa, M., MALDI-TOF mass spectrometry-based SNP genotyping, Pharmacogenomics, 3 (4): 537-48 (2002)). This assay can be readily performed by use of, for example, Sequenom Mass ARRAY high throughput SNP analysis system (http://www.sequenom.com/Files/applications/hme_assay.html).

[0111](9) Other Detection Methods

[0112]Detection of SNPs of the human IRS-2 gene can also be performed through, for example, any of the below-described various methods, which have conventionally been known as DNA sequencing methods or mutation detection methods.

[0113](a) PCR-SSO method employing sequence-specific oligonucleotide

[0114]A method in which a probe for a mutation is immobilized on a carrier; a sample (gene amplified product) is hybridized with the probe; and a difference in hybridization efficiency is determined on the basis of the presence of mismatch.

[0115](b) PCR-SSP method for point mutation detection

[0116]A method by use of a sequence-specific primer for gene amplification which is designed such that a nucleotide corresponding to point mutation becomes the 3'-end nucleotide, which method utilizes that a significant difference in PCR amplification efficiency occurs depending on the complementarity of the 3'-end nucleotide of the primer.

[0117](c) PCR-DGGE (denaturing gradient gel electrophoresis)

[0118]When DNA fragment including a mutation is hybridized with a normal DNA fragment, and then the thus-hybridized product is electrophoresed on a polyacrylamide gel with gradually increasing denaturant (e.g., urea or formamide) concentrations, the product is converted into single-stranded DNA fragments at a position of lower denaturant concentration, as compared with the case of non-mismatched homogenous double-stranded DNA fragments. The single-stranded DNA fragments migrate at a rate higher than the migration rate of the double-stranded DNA fragments, and therefore single nucleotide mutation can be detected through comparison of the mobilities of the DNA fragments.

[0119](d) PCR-DGGE/GC clamp method (Shefield, V. C., et al., Proc. Natl. Acad. Sci., U.S.A., 86, 232-236 (1989))

[0120]This method is a modification of the aforementioned PCR-DGGE, in which a region having a high GC content is added to a target DNA fragment for detection of a mutation. This method compensates for the disadvantage of the PCR-DGGE in detection of substitution, deletion, addition, or insertion of multiple nucleotides. This method requires a step of adding a GC clamp to a target DNA fragment for mutation detection.

[0121](e) RNase protection assay (Finkelstein, J., et al., Genomics, 7, 167-172 (1990))

[0122](f) In situ RT-PCR (Nucl. Acids Res., 21, 3159-3166 (1993))

[0123](g) In situ hybridization

[0124](h) Southern blotting (Sambrook, J., et al., Molecular Cloning a Laboratory Manual., Cold Spring Harbor Laboratory Press: NY. (1989))

[0125](i) Dot hybridization assay (see, for example, Southern, E. M., J. Mol. Biol., 98: 503-517 (1975))

[0126](j) Fluorescence in situ hybridization (FISH: Takahashi, E., et al., Hum. Genet., 86, 1416 (1990))

[0127](k) Comparative genomic hybridization (CGH: Kallioneimi, A., et al., Science, 258, 818-821 (1992)), (Spectral karyotyping: SKY: Rowley, J. D., et al., Blood, 93, 2038-2042 (1999))

[0128](l) Method employing yeast artificial chromosome (YAC) vector clone as a probe (Lengauer, C., et al., Cancer Res., 52, 2590-2596 (1992)).

[0129]Thus, polymorphisms (SNPs) or haplotype of the human IRS-2 gene can be detected.

[0130]According to the present invention, when a test sample is confirmed to have a polymorphism(s) of the human IRS-2 gene through detection procedures described above, the sample is judged as a subject with a high risk of drug-induced granulocytopenia.

[0131]Thus, before administration of a drug, it is determined whether the subject has a high risk of drug-induced granulocytopenia. Therefore, granulocytopenia, attributed to drug administration or other causes, will be prevented by this test.

[0132]Particularly, detection of SNPs of the human IRS-2 gene according to the present invention is effective in detecting the presence of a risk factor for drug-induced granulocytopenia in a human. That is, screening of the SNPs enables detection of a risk factor for human drug-induced granulocytopenia.

[0133]Thus, the present invention provides a method of detecting a polymorphism(s) of the human IRS-2 gene of a subject who may develop drug-induced granulocytopenia. That is, the genetic polymorphism(s) of the human IRS-2 gene can be used as an index to detect a subject who develops drug-induced granulocytopenia.

[0134]Oligonucleotide

[0135]The present invention also provides an oligonucleotide serving as a primer or probe for genetic polymorphism detection, which is used in the assessment (detection) method of the present invention employing PCR. No particular limitation is imposed on the oligonucleotide, so long as it can specifically amplify a specific region including polymorphisms (SNPs) of the human IRS-2 gene. The oligonucleotide can be appropriately constructed on the basis of sequence data of the human IRS-2 gene and synthesized through common methods.

[0136]More specifically, the oligonucleotide can be synthesized through a generally employed chemical synthesis method such as the phosphoroamidite method or the phosphotriester method, or can be synthesized by use of a commercially available automated oligonucleotide synthesis apparatus such as Pharmacia LKB Gene Assembler Plus (product of Pharmacia). A double-stranded fragment can be obtained by annealing of a chemically synthesized single-stranded oligonucleotide and its complementary strand under appropriate conditions, or synthesized by using an appropriate primer and DNA polymerase.

[0137]Preferred examples of the aforementioned oligonucleotide serving as a probe or primer include partial oligonucleotides corresponding to a DNA fragment designed so as to contain a polymorphism of the human IRS-2 gene. These oligonucleotides have at least a sequence of 10 bases (generally about 10 to 35 a sequence of bases). The oligonucleotide serving as a primer pair may be oligonucleotides having two sequences which are designed and synthesized so as to sandwich SNP of the human IRS-2 gene (genomic sequence). The oligonucleotide serving as a probe may be its positive clone per se.

[0138]Preferred examples of the aforementioned oligonucleotide serving as a probe or primer include partial sequences corresponding to a DNA fragment designed so as to contain at least one of the following polymorphisms: C to A conversion at position 4,587 upstream of the translation initiation codon of the human IRS-2 gene (C-4587A); AT deletion at position 2,510 upstream of the translation initiation codon of the human IRS-2 gene (AT-2510del); A to C conversion at position 1,164 upstream of the translation initiation codon of the human IRS-2 gene (A-1164C); A to G conversion at position 15,870 from the translation initiation codon of the human IRS-2 gene (A15870G); A to G conversion at position 29,793 downstream from the translation initiation codon of the human IRS-2 gene (A29793G); and C deletion at position 31,532 downstream from the translation initiation codon of the human IRS-2 gene (C31532del). These primer or probe has at least a sequence of 10 bases (preferably at least a sequence of 15 bases).

[0139]Specific examples of the oligonucleotide include forward primers and reverse primers of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11 and 13 to 16, and oligonucleotide primers for direct sequencing of SEQ ID NOs: 3, 6, 9, 12, and 17, which are described below in Examples.

[0140]No particular limitation is imposed on the gene-specific probe employed in the present invention, so long as it can detect any of the aforementioned C-4587A, AT-2510del, A-1164C, A15870G, A29793G, and C31532del.

[0141]Kit for Assessment

[0142]The assessment (detection) method of the present invention can be more easily performed by use of a reagent kit for detecting SNPs of the human IRS-2 gene of a sample. The present invention also provides a kit for such assessment.

[0143]A kit of the present invention includes, as an essential component, at least a DNA fragment which hybridizes with a partial or entire--nucleotide sequences or its complementary sequences--including six SNPs of the human IRS-2 gene, or which hybridizes with a sequence containing an ologonucleotide with one base or several bases before a polymorphic site. Another kit of the present invention includes, as an essential component, a restriction enzyme (e.g., Afa I) that specifically recognizes a sequence formed of several nucleotides (including the aforementioned polymorphic site).

[0144]Other components of the kit of the present invention are, for example, a labeling reagent, and reagents required for PCR (e.g., Taq DNA polymerase, deoxynucleotide triphosphate, or a primer for DNA amplification). Examples of the labeling reagent include chemical modification substances such as a radioactive isotope, a light-emitting substance, and a fluorescent substance. The DNA fragment per se may be conjugated in advance with such a labeling reagent. The kit of the present invention may further include, for example,--appropriate reaction diluents, standard antibodies, buffers, detergents, or reaction stopping solutions, to perform measurement conveniently.

[0145]Use of the aforementioned assessment method of the present invention enables provision of an examination method for the risk of human drug-induced granulocytopenia by use, as an index, of a detected genetic polymorphism which may cause drug-induced granulocytopenia in a human, particularly, an examination method for the risk of granulocytopenia attributed to administration of a drug (e.g., vesnarinone) which has already been reported to induce granulocytopenia (including agranulocytosis), before administration of the drug, as well as a diagnosis reagent and diagnosis kit employed for such an examination method.

[0146]The present invention will next be described in more detail by way of Examples, which should not be construed as limiting the invention thereto.

Example 1

Example 1

(a) Screening of Genetic Polymorphism in Relation to Granulocytopenia Attributed to Drug Administration

[0147]In order to find genetic polymorphisms in relation to granulocytopenia attributed to drug administration, there were employed subjects who had received vesnarinone (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline).

[0148]In Japan, vesnarinone, which is a commercially available drug applicable to chronic heart failure (mild to moderate heart failure), has been reported to induce side effects including leukopenia, granulocytopenia, and agranulocytosis, and therefore, administration of this drug requires observation of such side effects and frequent examinations of granulocytes.

[0149]Among subjects who had received vesnarinone, had orally agreed to cooperate with investigation of the cause for vesnarinone-induced granulocytopenia between May 1991 and October 1996, and had accepted to provide a blood sample, there were employed 84 subjects (male/female ratio=1.21:1) who had again agreed in writing to cooperate with genetic analysis according to ethical guidelines between July 2001 and December 2001. Genomic DNA was extracted from a blood sample (or a cell sample derived therefrom) of each of the subjects who had again agreed described above. through a common method, and was employed for the below-described tests.

(b) Classification Criteria of the Subjects

[0150]On the basis of the below-described criteria, the subjects were classified into the following two groups: a group of subjects with granulocytopenia, and a group of subjects without granulocytopenia.

[0151]Among the subjects, subjects having leukocytes or neutrophils which were decreased to half or less following vesnarinone administration, and having the number of leukocytes of 2,000/mm³ or less, or the number of neutrophils of 1,000/mm³ or less were classified as "subjects with granulocytopenia". On the other hand, subjects who did not decrease the number of neutrophils after vesnarinone administration for 90 days or more were classified as "subjects with granulocytopenia".

[0152]Each of these groups was further classified into two groups according to sex, to thereby become four subgroups; i.e., a group of 13 male with granulocytopenia (group A), a group of 17 female with granulocytopenia (group B), a group of 33 male without granulocytopenia (group C), and a group of 21 female without granulocytopenia (group D).

(c) Gene and Polymorphism (SNP) to be Analyzed

[0153]115 Candidate genes were selected from among, for example, cytokine-related genes, MHC region genes, G-CSF-related genes, TNF-α-related genes, NF-κ-related genes, cAMP-related genes, and potassium channel-related genes.

[0154]Polymorphisms (SNPs) of these candidate genes were searched from the database of Japanese Single Nucleotide Polymorphisms (JSNP:http://snp.ims.u-tokyo.ac.jp/index_ja.html), and 188 candidate SNPs were selected.

(d) Analysis Method

[0155]The SNPs were analyzed by the Invader assay. The Invader assay was performed with reference to the following publications (1) and (2):

[0156](1) Lyamichev, V., et al., Nat. Biotechnol., 17: 292-296 (1999); and

[0157](2) International Patent Publication WO 9823774 (98/6/4).

[0158]In order to amplify genomic DNA regions including each of the candidate SNPs by PCR, a set of primers for amplifying these regions was designed on the basis of genomic DNA sequence data around the SNPs searched from JSNP, and each of the primers was synthesized.

[0159]An Invader assay reagent for determining genotypes of the candidate SNPs was prepared by a common method on the basis of genomic DNA sequence data around the SNPs searched from JSNP.

[0160]Each PCR was performed by use of genomic DNA (1 ng) as a template. A reaction mixture (15 μL) contained dNTPs (0.25 mM), the PCR buffer attached to TaKaRa Ex Taq (Takara) ( 1/10 of the total amount for reaction), a set of a forward and a reverse primer (130 nM each), and TaKaRa Ex Taq (Takara) (0.5 U). Each sample was amplified in DNA Engine PTC-0200 (MJ Research). The PCR was performed for 94° C. for 2 minutes; then 50 cycles of 94° C. for 30 seconds, 56° C. (or 58° C. or 60° C.) for 30 seconds, and 72° C. for 90 seconds.

[0161]Invader assay reaction was carried out mixing the Invader assay reagent with the PCR product that was diluted with a range of 10 to 1.000-fold. A reaction mixture (15 μL) contained 5.5× Invader buffer (2.75 μL), 10× Bioplex FRET Probe Mix (0.75 μL), Cleavase VIII enzyme (200 ng/μL) (1 μL), PPI Mix (3 μL), and the diluted PCR product described above (7.5 μL). The reaction was performed at 62° C. for 60 to 120 minutes.

(e) Genotype Determination Method

[0162]Genotype of each subject was determined based on the intensities of two different fluorescent materials detected as a result of the Invader assay reaction. Thus, the genotypes of the 188 SNPs located in the 115 genes of each subject were determined by the Invader assay.

(f) Statistical Analysis Method

[0163]The allele frequencies in the group of subjects with granulocytopenia were compared to that of subjects without granulocytopenia by the contingency χ square test. The odds ratio was estimated through the Brown method (Brown, C. C., Am. J. Epidemiol., 113: 474-480 (1981)). The 95% confidence interval of odds ratio was calculated through the Woolf method.

(g) Results

[0164]The results of analysis of the 188 SNPs in the 115 genes through the aforementioned method revealed that polymorphism with the most statistically significant association was located in the insulin receptor substrate 2 (IRS-2) gene (JSNP ID: IMS-JST040476). In these subjects, this SNP was in Hardy-Weinberg equilibrium.

[0165]The result suggests that the SNP in the human IRS-2 gene is intimately related to the granulocytopenia attributed to vesnarinone administration, and that the human IRS-2 gene is likely to play an important role in the pathogenesis of granulocytopenia.

[0166]The Human IRS-2 protein (translation product of the human IRS-2 gene) belongs to the insulin receptor substrate protein family (IRSs: IRS-1, IRS-2, IRS-3, and IRS-4). IRSs are activated by insulin receptor tyrosine kinase that phosphorylates tyrosine residues of IRSs. As has been known, Phosphorylated-IRSs are related to the insulin action that is to promote glucose uptake by accelerating translocation of glucose transporter 4 (GLUT-4) from cytoplasm to cell membrane via PI-3 kinase activated by phosphorylated-IRSs. In order to conduct further studies on the relation between the human IRS-2 gene and vesnarinone-induced granulocytopenia, another polymorphisms of the human IRS-2 gene were analyzed.

Example 2

Association Analysis of the Human IRS-2 Gene and Drug-Induced Granulocytopenia

[0167]By use of the subjects described in Example 1, polymorphisms of the human IRS-2 gene were analyzed as follows.

[0168](a) Discovery of Polymorphisms in the Human IRS-2 Gene

[0169]In order to screen the entirety of the IRS-2 gene including a promoter region involved in its transcriptional regulation, the genomic sequence including the IRS-2 gene was obtained from GenBank (accession number AL162497, full length: 143,409 bp) by inquiring the human IRS-2 mRNA sequence, which is registered in GenBank (accession number XM_--007095). The structure of the human IRS-2 gene was estimated through detailed comparison between the human IRS-2 mRNA sequence and the genomic sequence including the IRS-2 gene. Notably, a complementary strand of the above-obtained genomic sequence was employed for the comparison such that the above-compared sequences were in the same direction (from 5' to 3').

[0170]It is inferred from the result that the human IRS-2 gene has a full length of 32,730 bp including two exons and one intron.

[0171]On the basis of the above sequence data, primers were designed and synthesized.

[0172]For discovery of polumorphism, there were employed genomic samples from 12 subjects with granulocytopenia and 12 subjects without granulocytopenia among the subjects described in Example 1.

[0173]Each PCR was performed by use of genomic DNA (5 ng). A reaction mixture (10 μL) was prepared to contain dNTPs (1.25 mM), magnesium chloride (3.9 mM), ammonium sulfate (16.6 mM), Tris-HCl (67 mM, pH 8.8), β-mercaptoethanol (10 mM), a set of a forward primer and a reverse primer (1.25 mM), and TaKaRa Ex Taq (Takara) (0.5 U). If desired, DMSO (dimethyl sulfoxide) was added to the reaction mixture such that the final concentration was 10%.

[0174]Each sample was amplified by use of DNA Engine PTC-0200 (MJ Research) or GeneAmp PCR System 9700 (PE Applied Biosystems). The PCR was performed at 95° C. for 2 minutes; then 37 cycles of 94° C. for 30 seconds, 56° C. (or 58° C.) for 30 seconds, and 72° C. for 3 minutes with final extension at 72° C. for 7 minutes.

[0175]Each of the PCR product was employed to react with BigDye® Terminator RR mix (PE Applied Biosystems).

[0176]On the basis of nucleotide sequence data obtained by ABI Prism 3700 DNA Analyzer (PE Applied Biosystems), genetic polymorphisms were detected and their positions on the human IRS-2 gene were confirmed by use of SEQUENCHER 3.1 (product of Gene Codes)

[0177](b) Sample Amplification and Genotype Determination Method

[0178]In order to determine the genotype distribution, all polymorphisms identified by the discovery above were analyzed in the all subjects described in Example 1 by amplifying the regions containing the polymorphisms with primer sets and sequencing the PCR products under the condition described above.

[0179](c) Statistical Analysis

[0180]In addition to the statistical methods employed in Example 1, a pair-wise linkage disequilibrium coefficient (D'=D/Dmax or D/Dmin) was calculated by use of the method by Thompson, et al. (Thompson, E. A., et al., Am. J. Hum. Genet. 42: 113-124 (1988))

[0181](d) Results

[0182]The analysis results revealed that, in the subject groups, all the polymorphisms analyzed in the present Example are in Hardy-Weinberg equilibrium.

[0183]The analysis results also revealed that six polymorphisms were intimately associated with granulocytopenia induced by vesnarinone administration. Tables 1 through 6 show the results of statistical analysis on the six polymorphisms respectively.

TABLE-US-00001 TABLE 1 Polymorphism subjects with subjects without The number of agranulocytosis agranulocytosis OR genotype N (%) N (%) χ² (df = 1) P (95% CI) C-4587A CC 7 (25.0) 29 (59.2) 8.36 0.0038 4.35 CA + AA 21 (75.0) 20 (40.8) (1.56-12.16) Total 28 49

TABLE-US-00002 TABLE 2 Polymorphism subjects with subjects without The number of agranulocytosis agranulocytosis OR genotype N (%) N (%) χ² (df = 1) P (95% CI) AT-2510del AT 7 (24.1) 28 (57.1) 8.02 0.0046 4.19 ATdel + del 22 (75.9) 21 (42.9) (1.51-11.64) Total 29 49

TABLE-US-00003 TABLE 3 Polymorphism subjects with subjects without The number of agranulocytosis agranulocytosis OR genotype N (%) N (%) χ² (df = 1) P (95% CI) A-1164C AA 8 (26.7) 29 (59.2) 7.90 0.0049 3.99 AC + CC 22 (73.3) 20 (40.8) (1.48-10.73) Total 30 49

TABLE-US-00004 TABLE 4 Polymorphism subjects with subjects without The number of agranulocytosis agranulocytosis OR genotype N (%) N (%) χ² (df = 1) P (95% CI) A15870G AA 10 (37.0) 36 (73.5) 9.67 0.0019 4.71 AG + GG 17 (63.0) 13 (26.5) (1.72-12.88) Total 27 49

TABLE-US-00005 TABLE 5 Polymorphism subjects with subjects without The number of agranulocytosis agranulocytosis OR genotype N (%) N (%) χ² (df = 1) P (95% CI) A29793G AA 11 (36.7) 39 (73.6) 10.90 0.00096 4.81 AG + GG 19 (63.3) 14 (26.4) (1.84-12.56) Total 30 53

TABLE-US-00006 TABLE 6 Polymorphism subjects with subjects without The number of agranulocytosis agranulocytosis OR genotype N (%) N (%) χ² (df = 1) P (95% CI) C31532del CC 9 (33.3) 34 (70.8) 9.93 0.0016 4.86 Cdel + del 18 (66.7) 14 (29.2) (1.76-13.39) Total 27 48

[0184]In the Tables, a polymorphism with the symbol "del" corresponds to a deletion polymorphism, and the position number of each "polymorphism" correspond to the position number counting from A (position number: +1) of ATG (translation initiation codon) of the IRS-2 gene. A polymorphism shown by the position number with the symbol "-" is located 5' upstream of A of ATG (translation initiation codon) of the IRS-2 gene.

[0185]As shown in Tables 1 through 6, a subject having at least one of these six polymorphisms has showed association with the granulocytopenia by vesnarinone administration. In other words, these results suggest that one of these polymorphisms, "C-4587A", which is a polymorphism obtained through C to A conversion at position 4,587 upstream of the translation initiation codon of the human IRS-2 gene; "AT-2510del", which is a polymorphism obtained through AT deletion at position 2,510 upstream of the translation initiation codon of the coding region; "A-1164C", which is a polymorphism obtained through A to C conversion at position 1,164 upstream of the translation initiation codon of the coding region; "A15870G", which is a polymorphism obtained through A to G conversion at position 15,870 downstream from the translation initiation codon of the coding region; "A29793G", which is a polymorphism obtained through A to G conversion at position 29,793 downstream from the translation initiation codon of the coding region; and "C31532del", which is a polymorphism obtained through C deletion at position 31,532 downstream from the translation initiation codon of the coding region, is associated with granulocytopenia by vesnarinone administration. FIG. 1 shows the positions of these six polymorphisms in the human IRS-2 gene. In FIG. 1, "+1" corresponds to A of ATG (translation initiation codon).

[0186]Table 7 shows the results of analysis of linkage disequilibrium between these polymorphisms.

TABLE-US-00007 TABLE 7 D' C- SNP 4587A AT-2510del A-1164C A15870G A29793G AT-2510del 1.000 -- -- -- -- A-1164C 1.000 1.000 -- -- -- A15870G 1.000 1.000 1.000 -- -- A29793G 0.956 0.956 0.957 1.000 -- C31532del 0.952 0.953 0.953 1.000 1.000

[0187]As is clear from Table 7, all the polymorphisms, which are intimately associated with granulocytopeniaby vesnarinone administration, are in almost complete linkage disequilibrium. Specifically, when the allele at position 4587 upstream of the translation initiation codon of the human IRS-2 gene is A (mutant type), each of the polymorphisms at the other five polymorphic sites has the genotype which shows association with granulocytopeniaby vesnarinone administration.

[0188]The results strongly suggest that these six polymorphisms of the human IRS-2 gene play an important role in the granulocytopenia by vesnarinone administration.

[0189]Recently, it has been reported that when HL-60 cells (myeloblasts) are differentiated into granulocytes by DMSO stimulation, the amount of IRS-2 protein is increased (Schacher, D. H., et al., J. Immunol., 164: 113-120 (2000)). This report suggests that IRS-2 is closely associated with granulocytic differentiation. Among the human IRS-2 gene polymorphisms analyzed or identified by the present inventors, three polymorphisms (C-4587A, AT-2510del, and A-1164C) are located in the promoter region, which regulates the transcription of the human IRS-2 gene. Therefore, it may be supported that the transcriptional levels of IRS-2 gene are reduced by these polymorphisms located in the promoter region, whereby a differentiation into granulocytes is also reduced.

Example 3

[0190]This Example is related to other methods for detecting the six polymorphisms of the human IRS-2 gene of the present invention. In this Example, these polymorphisms were detected through the below-described methods (a) and (b).

(a) Direct Sequencing

[0191]DNA fragments were amplified by use of forward primers (SEQ ID NOs: 1, 4, 7, 10, 13, and 15) and reverse primers (SEQ ID NOs: 2, 5, 8, 11, 14, and 16) described in Table 8, such that these amplified PCR products included the six polymorphisms according to the present invention. This operation was performed by DNA Engine PTC-0200 (MJ Research) or GeneAmp PCR System 9700 (PE Applied Biosystems) Each PCR was performed for 95° C. for 2 minutes; then 37 cycles of 94° C. for 30 seconds, the annealing temperature shown in Table 8 for 30 seconds, extension reaction at 72° C. for the time shown in Table 8 with final extension at 72° C. for 10 minutes. For each of the DNA fragments, as described in Table 8, the annealing temperature and the extension reaction time are 58° C. to 60° C. and 0.5 minutes to 3 minutes, respectively.

TABLE-US-00008 TABLE 8 Nucleotide Nucleotide position position Annealing Extension Forward number in Reverse number in temperature time primer AL162497 primer AL162497 (° C.) (min) DMSO C-4587A SEQ ID NO: 1 131420-131399 SEQ ID NO: 2 130318-130339 60 3 - AT-2510del SEQ ID NO: 4 128930-128911 SEQ ID NO: 5 127491-127510 60 3 - A-1164C SEQ ID NO: 7 127837-127818 SEQ ID NO: 8 126460-126479 60 3 + A15870G SEQ ID NO: 10 110260-110240 SEQ ID NO: 11 109859-109879 60 3 - A29793G SEQ ID NO: 13 96209-96190 SEQ ID NO: 14 96070-96091 58 0.5 - C31532del SEQ ID NO: 15 94616-94595 SEQ ID NO: 16 93139-93159 60 3 -

[0192]The component of a reaction mixture is as described in Example 2-(a). Notably, DMSO was added to the reaction mixture for detecting "A-1164C" such that the final concentration was 10% (see the column "DMSO" of Table 8).

[0193]G at position 23 of the reverse primer (SEQ ID NO: 14) employed for detection of "A29793G" described in Table 8 was a replaced base to create the polymorphic site that is recognized by the restriction enzyme Afa I.

[0194]The polymorphisms other than "A29793G" were detected by direct sequencing [the dideoxy method (Sanger, et al., Proc. Natl. Acad. Sci., U.S.A., 74, 5463-5467 (1977) or the Maxam-Gilbert method (Methods in Enzymology, 65, 499 (1980). Table 9 shows primers to determine genotype of each polymorphism (SEQ ID NOs: 3, 6, 9, 12, and 17).

TABLE-US-00009 TABLE 9 Primer for Nucleotide position sequencing number in AL162497 C-4587A SEQ ID NO: 3 130343-130363 AT-2510del SEQ ID NO: 6 128581-128562 A-1164C SEQ ID NO: 9 126912-126929 A15870G SEQ ID NO: 12 110249-110231 C31532del SEQ ID NO: 17 94556-94537

(b) PCR-RFLP (Restriction Enzyme Fragment Length Polymorphism) Analysis

[0195]"PCR-RFLP (restriction enzyme fragment length polymorphism) analysis was performed to detect "A29793G". Specifically, a reaction mixture (20 μL) contained the PCR product (10 μL), 2 units of restriction enzyme Afa I (10 units/mL, Takara), and 10× Buffer T attached to the restriction enzyme (2 μL). BSA was added to the reaction mixture such that the final concentration was 0.01%, and the resultant mixture was incubated at 37° C. for 16 hours. Digested DNA fragments were separated by use of 4% agarose gel and visualized by ethidium bromide staining and ultraviolet transillumination.

[0196]When DNA extracted from a subject sample is applied to any of the detection methods for the six polymorphisms of the human IRS-2 gene described above in the Examples before administration of a drug which may induce granulocytopenia, there can be determined the possibility of an drug-induced granulocytopenia (including agranulocytosis); i.e., the risk of drug-induced granulocytopenia. Thus, according to the present invention, the risk of granulocytopenia attributed to vesnarinone administration can be examined or assessed by of the analysis of DNA from a subject.

INDUSTRIAL APPLICABILITY

[0197]The present invention is useful for examining or assessing the risk of human drug-induced granulocytopenia, particularly useful for examining or assessing the risk of human drug-induced granulocytopenia before administration of a drug that has already been reported to induce granulocytopenia (including agranulocytosis).

TABLE-US-00010 SEQUENCE LISTING <110> Otsuka Pharmaceutical Co., Ltd. <120> A method for determining the risk of drug-induced agranulocytosis <130> 0P0046 <140> <141> <160> 17 <170> Patentln Ver. 2.1 <210> 1 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) 400> 1 accactgtat ttgtgacaac tc 22 <210> 2 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 2 aaatatggat cagtctcttt cc 22 <210> 3 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 3 atgttcattt tatgagggag g 21 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 4 aactgccaat ccagagctgc 20 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 5 tctcaccaca ccgcttcaag 20 <210> 6 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 6 ccacattttc ttcaagcacc 20 <210> 7 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 7 gagcttgctg ggatctgaac 20 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 8 atgtgactcg gcgttacgca 20 <210> 9 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 9 ccttgcagtg gaagcatg 18 <210> 10 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 10 ctatcccgat tcctagatgt c 21 <210> 11 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 11 gactcatctg tgactaactc c 21 <210> 12 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 12 cctagatgtc agcttgccc 19 <210> 13 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 13 tctggaactc cagagattgc 20 <210> 14 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs

of Insulin receptor substance-2 (IRS-2) <400> 14 tgctgagcgt cttcttttaa tggta 25 <210> 15 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 15 gaggcttttt tagaggaaga cc 22 <210> 16 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 16 catgtcatgg agggagcatt c 21 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer sequence for amplification of SNPs of Insulin receptor substance-2 (IRS-2) <400> 17 gcaaaagtct tcctgcttcc 20

Sequence CWU 1

19122DNAArtificial SequenceSynthetic DNA 1accactgtat ttgtgacaac tc 22222DNAArtificial SequenceSynthetic DNA 2aaatatggat cagtctcttt cc 22321DNAArtificial SequenceSynthetic DNA 3atgttcattt tatgagggag g 21420DNAArtificial SequenceSynthetic DNA 4aactgccaat ccagagctgc 20520DNAArtificial SequenceSynthetic DNA 5tctcaccaca ccgcttcaag 20620DNAArtificial SequenceSynthetic DNA 6ccacattttc ttcaagcacc 20720DNAArtificial SequenceSynthetic DNA 7gagcttgctg ggatctgaac 20820DNAArtificial SequenceSynthetic DNA 8atgtgactcg gcgttacgca 20918DNAArtificial SequenceSynthetic DNA 9ccttgcagtg gaagcatg 181021DNAArtificial SequenceSynthetic DNA 10ctatcccgat tcctagatgt c 211121DNAArtificial SequenceSynthetic DNA 11gactcatctg tgactaactc c 211219DNAArtificial SequenceSynthetic DNA 12cctagatgtc agcttgccc 191320DNAArtificial SequenceSynthetic DNA 13tctggaactc cagagattgc 201425DNAArtificial SequenceSynthetic DNA 14tgctgagcgt cttcttttaa tggta 251522DNAArtificial SequenceSynthetic DNA 15gaggcttttt tagaggaaga cc 221621DNAArtificial SequenceSynthetic DNA 16catgtcatgg agggagcatt c 211720DNAArtificial SequenceSynthetic DNA 17gcaaaagtct tcctgcttcc 2018143409DNAHomo sapiensmisc_feature(1)..(143409)AL162497 an antisense strand 18gcaaatcaaa accactgtgc gatatcacct acacccttta ggatggctat taccagagac 60aagtgataaa tgtttgcaga gtgtggagaa aagagaattc ttgtacactg ttggtaggaa 120tgtagattgg aagagccatt ctggaaaaca aaatggagct tccttaaata aatgaaaaat 180agaactacca taagacccag caaccctctt ctgggtatat atccaacaga gaggaaatgg 240ctaccttata aaaatattgg cactcccatg tgcactgcag cattatttac agtagccaag 300gtatggaaac cacctaagtg tccattgaca gacaaatgga tgaagaaatt cctcgatgag 360attggagatt attattctaa gtgaagtaac tcaggaacag aaaaccaaac atcgtgtgtt 420cccactgaca tacggaagct aagctatgag gatgcaaagg cataagaatg acacaacgga 480ctttgaggac ttagggggaa ggctgggagg aggatgaggg ataaaggact acaaatatgg 540tgcagtgtat actgctcagg tgatgggtgc gccaaaatct cacaaatcac cacaaaagaa 600cctactcatg taaccaaata tcacctgttc cccaatacct tatggaaaaa taaaataata 660aactaaaata aataatgtca catatgtaca acagaatgtt atttggacct cataaagaat 720gagatcatcc catatgccac aacatcgatg aggctagagg acattatgct aagtggaata 780aaccagacac agtaagaaaa atattgcatg atctcactca tatgtggaat ctaaaaagaa 840aaattcaaat ggagatagaa aataaagcag ggttctgggg agatgcaagt tggaggacac 900aacgtagccc acatgcaaga tgaacacctc tagagatttc aggcacgaaa tgaggacact 960aagggccctg accaccctgg agtaagagct gacactactg ccttcccctg cctcggggga 1020tcatcaccag ccacccagtg ggtgaagagg aacagtaaga aagaagccat ggggcttccc 1080gcaatagctc ggtgtggtag agtctatcta aatgcagaat actttgatgg aggttactgg 1140ctgggtcact gccactgagt ctctatcagg agctgggaca gggtggctcc catgcctggt 1200tccacagcca gagaccttgc tgagtgacat gcagatttga gggacatggc tcatcttcct 1260gcctgctact ctctagggct cactgatgaa tttctagtga cagtgtgttc tagaagttag 1320ctctaactat aaaacatttt ttcaggtctt ccactttctg aacaatctga tcctaaagcc 1380actgtgtgta tccaaacaag ggggatatcc gcaccgatgg aagggaccac agaggaacat 1440agtgagcaag gatgggattg ggggaggttt gcaagagccc gagctgggca ttggtagggg 1500acggtggcgg tccacatggc tgggtcatgg tgtcagagcc ccagtgcaat gaggaccggg 1560ctcctgcagg agtaggacca tgggactttc agcctgagta gggtagagag agtgtccaag 1620caggggaagg gactgaatgg aagggtggca ggcacccaga aaaatgaatg gggtttaagg 1680gggaagcagc tggagcaaag tgtgcctctg ggcagggcaa ggagggcttc ggtgtaggaa 1740gggaggaaaa ggggctttca tgtgggcgga tggtccagac aggaatggca cagcattact 1800gggcagggag gatgctggcc tgggatgcag gccagtgcct ggcctcagag atcatacaga 1860atttggaatc ggactgtgca gggggaggtg gcaatgctga tagaaaatgg caggggtggc 1920acagggtgtg aatgagagtc acaaatatac aaaggaagaa agtggggtgg actctgaggt 1980gcttgagtga actgaagata ttagcaccaa ctcatggctt tccatataga cagagctaga 2040gacaaacata gacataaaca tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtc 2100tatatgcata tgctgtccag ctctgtgcac tgaggtacac ccagatcatg gtatctaaag 2160cccattctcc tcttgggatt cagctctttt tggagaacca gctgacccat gatccagagc 2220aggcagggtc cacaatgact cagaaacatc ttgaggacct gctcagagaa tgacaacaca 2280cgggccagtg ggaacagctt ccaaacccca gcaaaggtga acagtaagat aagtaatgat 2340aattccaggt tataatccaa taaataagat agaaaactac acatccatac tgacataaat 2400acaacataaa tgaataaatt aaacgttgaa tgaagagcag agtatttaca cagttttaag 2460ctagtcctcc atgtaatact aattaattac aaaggaagaa aggagtgaag aaaccacaga 2520caccacctcc atcaggtcac cagtgtgaac atcgtcagta accgggcaaa ttgcagtcct 2580gccgacctga gagcacggag tgaggcggtc ccagggtcgc tcctgggttc tcctgccaag 2640gacgctaaac ctgaatctgc tcatgaggaa gcatcaggca gccccgtgct gggggaaatc 2700ctgcaatgta actggcctag agccattaga gtgtcaaggc cacgaaagtc acagaaagac 2760tgaggaactt ttccaggtga atggagccta ataaaacaca acagccaaat gcagcatgta 2820gctctgagat ggttcctttt gtttttaagg atgtctgggg gcaaatatga acagggtctg 2880agaattaggc attaggaata tatcaacgtt gattatctga ttctgttaac tctactgtgg 2940ttgtgtagga gcatatttgt gttggtacaa aatacacact aaagtattcg tattcaggga 3000tgacaagata tcatgcaggc aacttactct caaaaggtcc agcaaaaaaa aaattatttc 3060tgttgtcctt gcaactattt tgtaagtagt ttgtacttgt taggaaaaaa aaaattcaga 3120cttcttataa ctaatatcct tatgtgtgaa gaaatgataa aaatttccaa tgaaaataaa 3180ttcccaaaca cctgggcagc ctctgcaccc atttggtaaa ctcctggctt tcatgcgctg 3240tagttttgac ctgcagtggt tcccaggtca catgagtctc tgctgtaatg agacaggtat 3300gcctcacgat gtcagtgcat ggcatcatga tgaaaacccc cctaagtttg ccagtgtcct 3360cagtaaagga cagtgagacc aacagatgat atccatcagc tgccaaccca ggagggctgg 3420aaagattgcc tagccctacc agtgtgggtc aagtaatttt tgttcttgga atctagtcaa 3480acgaacaccc aataggaaga gatcagagaa tcttaggacc caggataagg gcagcactaa 3540aaataaccaa aggtatcatt tattctgtgt gataaacctc ccactcaccc catcgcgtgc 3600catcatcgca atagtctggg gaagtgagta ccgttactat ctcatatggg ccatgagaaa 3660ctgaaagctc agaaaggaac tccaacaaat ttacaagaaa aaaacaaaca accccatcaa 3720caagtgggtg aaggatatga acagacactt ctcaaaagaa gacatttatg cagccaaaaa 3780acacatgaaa aaatgctcat catcactggc catcagagaa atgcaaatca aaaccacaat 3840gagataccat ctcacaccag ttagaatggt gatcattaaa aagtcaggaa acaacaggtg 3900ctggagagga tgtggagaaa caggaacact tttacactgt tggtgggact gcaaactagt 3960tcaaccattg tggaagtcag tgtggcgatt cctcagggat ctagaactag aaataccatt 4020tgacccagcc atcccattac tgggtatata cccaaaggat tataaatcat actgctataa 4080agacacatgc acacgtatgt ttactgcagc actattcaca atagcaaaga cttggaacca 4140acccaaatgt ccaacaatga tagactggat taagaaaatg tggcacatat acaccatgga 4200atactatgca gccataaaaa atgatgagtt catgtccttt gtagggacat ggatgaagct 4260ggaaaccatc attctcagca aactatcaca aggacaaaaa accaaacacc gcatgttctc 4320actcataggt gggaactgaa caatgagaac acatggacac aggaagggga acatcacaca 4380ctggggcctg ttgtggggtg ggggtagggg ggagggtagc atttagagat atacctaatg 4440ttaaatgacg acttaatggg tgcagcacac caacatggca catgtataca tatgtaacta 4500acctgcacgt tgtgcacatg taccctaaaa cttaaagtat aaaaaaaaaa aaacttggct 4560actgtcactc caccgtgtgt attcatctcc taagggagat gcttacattc aaagggggtg 4620caattattct ctctctctcc ctcacagagt aggaacctga gacacagaaa tgatcagcgg 4680gctgcctgag atcacatggc taatgaggga tgaattgaac attctcaaat tctcattcac 4740caccaactcc tcatgtcctg tgctgcccca cctcccaggt gggacttgca ggtcttttaa 4800gaacttgcat tcattgacac tattttgacg acagtaaact ggtagcaaaa ttaatgtgag 4860cacattcaaa tacaatttat tttttaagca gcctgggaga gtggaaaaag cactcctggg 4920ctcagcctcc atcacctgct agctgtgagc ttctgtacaa tctcttcact ttttccaatc 4980cccccaatgt ccttccttag attgaaatcg actctttaga atcagcacat tcaaggaggt 5040aaagtcacag cttgtcttgc agcccaaacc tcccatccaa taggcccatg gcaaagaacc 5100cacaggctgg gagcttcgca tcaggcgtcc ttgtttttgt ttgagccttt tctttcaaat 5160atatggataa tgaccacgtt tggggctaaa cataaagcat tctattcatt aggaccatgt 5220cacggacttg tggcatgtgg gaaatattac catggctacg gaggaggtgc gtgtggatgc 5280tggcagcggg gagggagccc atgcctgcct ggttgctgct aaacaataag tcaatctgtg 5340tttcactggg gtgttagtgt tctgttccct ctcacctcct ggagaccaag gatgtctccc 5400tgacatcaag ctgagcagtg ggaagctgag atatgagaga agaaagggcc tccgggggac 5460tgtgtgcagg tgatggccct ggagcttcca ttcaattatt ccaccagcat gcaccgagtg 5520actgccatgt gcaaagcaag ccagcagtaa gctacattct atcaaggaga caatatggag 5580aaactctgca aggagcttcc acacaccgga tgccctttca tcactcaaag acatagtttc 5640catgccagtc ttagggcagt aagtgaaagg ctacaattag aacagacgaa tcccaaaacg 5700cagagcctct gctgtgcgcg aaccatgagt cagcacctcc acggtgcact aagcgtgagc 5760tggcacctcc acggtgcact aagcgtgagc tggcacctcc acggtgcact aaccgtgagc 5820tggcacctcc acggtgcact aagcatgagc tggcacctcc acggtgcacc aaccgtgagc 5880tggcacctcc acggagcact aaccatgtgt aggctttgaa ctagtctgtt ctggaacctt 5940gctttgctca ggaggttttt tcctgttcct tccctgtgtc cagtcctctt gagagaggaa 6000aaccaaacca tgctgccgct attccctttc ttgataacaa tctgaaatca ttctggccaa 6060actgggatgg gcacagtgct tttccacatt gacttttttt ctgcttccca tgtttaggct 6120caaatttcta aaacggacca gagatgtaaa agggatattc aagtataaag tcctgtataa 6180acgtaaggca taaatattat gatcctcatc acttttagga gagtgaggta gaatgatgat 6240tttaaaaatt aggaacaaag ttacttcttt gatctcttta ttagccactt ctaataatcc 6300ctgtcccact catcctaaaa cctccagccc cctccagtct cccatccagc cacacacaga 6360attaccacaa tctaaatgcg ccctttgaat cagacaatac tcctattgct attaataata 6420atatattggt tagtcaccat tataaagatt ttacaaaata catttatggc atcaccagcc 6480aacacataac aggttacttt tattaagttg catttgttat ccctgatctt cacaggattc 6540ttacaagaca ggtattaata tgcccacttt tatggttggg gaaggatgat tcacagttac 6600ggaaacttgc tcatactcag gaggaagcta agccatcttt ctggcccact accattgttt 6660gatttcacag tgctggacag ctggtgtcac cctcagaggc cataggtaac cacatcccca 6720gatccttaac agccaggccc cccgccacca cataactttg ggaaacacgg aagcccggaa 6780tgcagcccca tgggctctaa tccaggtcaa ctgggtggga caccccgccc ccgcgtacag 6840gcacccccac cccgcccctg ctacctctct aggtctgaaa gccccagcaa taagtctcat 6900cggacccgag ctgcgattat ttatgccttc ctttcatctt tgcttcggtc tcttggtcag 6960ggtgatttct tcatcctttt tgtagaaggc ttccctttgc attagcagct ttgctatagt 7020tctagaataa atgagcacag gaagaagacg ctgtcatacg ggaccgatcc gtgtccacat 7080gaagtcatca gatcggtatg ggtgagtggc aggcaaatcc ggtgtgggga agcggcaaag 7140cctgaggagc ctgcacttat caaagattaa acactttcag gttctttaaa ggacaaactc 7200tgagttttcc cagcgtagta tttgagctat ttgagggtct gaaaagatat cacacaggtt 7260accctgcgtt ttgacagcct ttccttactt taatccaagc ctgtggcaaa ctggttgtaa 7320actattactg aagaaatggc tctatatttc tattctctct ctctttctcc ctctcttccc 7380gtttgaaatg aaaacacagt tctttcatta gctcattaaa aaatttactc ctttgtgaat 7440attttgaaat cacagagcag atatatattt tatatcaaag actccagtga aatattgatc 7500acctgtgtgt ttcactccct aaattcacca taactgtgcc tacgtggctt gtttcaaata 7560cacatcttac cctccagttt gaagtttaaa tcattgtggt aggcgttgta cagaggattg 7620cttttttatt ttctgtgctt aagtgcaggg cagccaaaac aagaacataa ttatatcgtc 7680agagtcgata agcgcatcaa gcctctatca gatcttgctg ggctcagcaa ctgcctcaca 7740ggaagtgctg gggagctctt ccgccaccaa atccatttgg ctctatttag gaactaagta 7800caggaaggta gttattgtac aagattagtt tcctgtaggc cataaattgg cagtagcaga 7860aaaatacagg atgaatttat tagcgtgcaa ggtcagctag aaggaagaca aggctgagcg 7920attgcgcttg ttttctttca tttagcccac ctcctggacc tcagggctga aaaagaccct 7980ctaactactt aattacttct taatagtttt aagcaaattc aaaaggcctg cgcgttgcta 8040agtgcctgag gtaagagctg cctgggctag gttaggaatg cctgtttgga ctagagtttc 8100tgaaacctga ctaggcccct tataatctga ggctttgtga gttttctgcg tttttttttt 8160ttttttcctg ccttatttgg tgttgattgg ccaagcattt actttgaagc tagaatttta 8220tacttgggaa taaaggagta gcttctaata gtgaaaatat aaaatccatc aagtcaaaaa 8280tattgtttcc aaccagaggt atgataatgt gataaacatc tctgtagata tttgctttaa 8340agagaacaag gacagattgc atttaaaaaa atttttttta aagaatacca cttcaaaaac 8400actcatttaa aggtagccca aaaggtggaa tgacctcctt acacagacat ttctaccttc 8460aaggagaaaa cctcgctcag ttacctgagc ctctttacca tgttagacac atgtaattca 8520cattttaatt atactcagca tctgcagtga gttatgggag acccctcctt ctccatccct 8580gcttccactg ggcctgctca cgctgcctct cctcacagat accctggtgg agcatacagg 8640gctggatgcc tgaaagtaga aaggcagagt cctctctgtt ccttcctaga agacaaccct 8700gttttggaat atgctttcct gatttcttag taaactgcag cactttgatg ctgtaaaaag 8760cctcatgatc agctagcacc agctcctgtc ctgccatttg caaacaaagg gcccagttaa 8820ccttcactgg gtgaggccat cctcccctga gggcagcccc gaggggtgag aggagcctga 8880gggaggaagg cccgttcaga gacagacagg gctgctgttc ccggaggtcc aagggatgtc 8940actgcttctc tattgtggac atttgtccaa gctgtactgt cttgataaaa gagtttgaga 9000gcatttcgaa agcgcaggtc ttaaaacaga tctccaggtg aatttcacag cccccttccc 9060cagagcacag acgcagagta ccccacacag tgttcaggtg cccagccttg ctctggggta 9120gggtgggggc aggcattgca acgctccgac atttgctgaa cgactgggtc acagtagctt 9180ggctgatttt ctgttcctgt cactccctgg agatgtgggt ctgaggtgag ctctggcacc 9240aagcctacct ctctggcatt ggctagagcc tccgtgtcag gccagagtca acctctcgta 9300acctttccaa agccaattat cacaacacag attcagaaat taagggagaa gttcaaagcc 9360caaattgtgc cagaaggagc cttcgcaagg cagtctgagg ccaagcagtc gcaggcagtt 9420tcttcattta ctcaccaggg aagctgaagc ccggcattcc tgaaacaaag atagcttttc 9480ttttccttcc catgttgttc tgaagtaggt tttagccaat cccaaaaaat ctcaaatcaa 9540caaattttta gccctaaata atgatgggcc caattacctg ctctctgcca agcatacgac 9600aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaacataaca caattcttca 9660ctgaatctcc tggatttctt agtccaggca ccctcagaga catatgctta gatcctacgt 9720ctgcttctat agaaaataca aaggaacgta gctctggaaa ggagggagcg tgagattctg 9780agccagaaat gttcctgata gactttgaaa atgatttgga agttcttgct gactatctcc 9840ctgctatgaa gccgccccga gttagatgtg aagactaaag tggaagcctt cagcagcctg 9900tcctcaccag cctgctcctc tgtcttccac tctaccctgg gctgcgaccc tgagcagagc 9960agccagctgc agtgttactc cattgctgga gggctcctct gtgaacccac aggaaggtcc 10020ctgcctcaca gtgggtgacg gtgcatcctc cacctgctga gtggtgtgac ctccacacct 10080gctgggacgc atggtggctt gaacctcact gtctccactt tgcccagcag caatcttgcc 10140tttctccccc cacctcaaga cacccaccac ctacctctgt ggcttcacag ggcagatgcc 10200ctgttaagtt gtggtgcctg tccccagcac tgtttagggt tttttttgtt ttttgtttgt 10260ttgtttttgt tgtttttttt ttgacggagt ctcgctctgt cacccaggct ggagtgcaat 10320gccaagatct tgctcactgc aacatccgcc tcctgggttc aagcgattca cctccctcag 10380cctcctagta ggtgggacta caggtgccca ccaccaagcc cggctaattt ttgtattttt 10440agtagagacg gggtttcacc atgttggcca gactggtctc gaactcctgg cctcaagtga 10500tccgcctacc tcggcctccc aaagtgctga gattacaggc gtgagccacc gctcccagca 10560catgttatta aagtcatgga caccaccaag tgctcagctt cagaacagcc atgactgtaa 10620ctgttagacc caggaatggg aagaggaaaa agagtcttca gggccaccaa gttcttttgc 10680tgcaaatctt gaaaggttat cagaagcata aaattgatta tcttcaccca cacccagcaa 10740ccacacacac gcactcctga cttagggaaa gttatatgct gtcgaagaac cagcggtagc 10800aaatgctttt cctcaccagt gagttcagaa aatcctgcat ttatctggcc caaagtccgc 10860atctcagata aagtctgaac gtgataactg cagaccaaca gcagtcctat cccaaagctc 10920agtcaaagcc actctcaagc cagagaacag acaggactca gacagggtca gaacacaaca 10980gtgcaacatc actgaggaag taaacaagtc accaaagaaa caccagagaa attcgtggac 11040aatattccag gcattaccat gttagggcta gcatgttaaa agacagcata ttgtattggt 11100gtgttttttt aaattcttac tgaaaagtta gaaaatgagg aaacaaaatg tggtatatat 11160ctctttaatg gaatattatt tagtcataaa aaagaaatga agtgctagca cacactacaa 11220cgtgcatgaa cctttaaaca ttacgttaag tgaaagaagc cagacacaac atataacgta 11280tgattccatt tatatgaaat atccagagta cccaagtcaa tcatgacagg aagtggacta 11340gtagttgtaa gggactagga gtcaagagaa atggggtgtc atggctatgg ggcttctctt 11400tgggatgata gaacattctg aaattagatg gtgaagatgg ttgccaactc tgtgaataca 11460cgaacaacta ctgaactaca ctccttttaa aagttggtat catgatatgt gaattacatc 11520tttatggtga taaaataaat gaggggcggt ggcagaaaga aacagaaatg aattccctta 11580tccaatatgt cttcacattg gccttcatgt tgagccactt ttatgcagca atctgagaca 11640aaggccacta ggacttggat gggtacccaa tgttacaatg aaaccttcaa gaggacctag 11700tcaactcagt ttcctggcta gctgacatgt ccctctttga gttttagttt taatgaacct 11760gctaattcca gtggaactaa ggcctctaga aagaactgcc aacttggtca agaccttagt 11820agtctgaata acgttggcct ggaaaccatg cacgtttacc tattttgtaa caaaacccca 11880actcaatgaa atgtgtttgt ctttaactag tctcagggga tttacatttt gccatctata 11940gggcagggtt tcctggccaa cttgagctgg atttgcaggc aagcagattt cccaacctag 12000gtactctagc tttgtgttcc cttatgcact tttccaatga ccggatgatg gcaagccccc 12060tggctcagat ccccaaattt ccacatcagt aaatgttgag aaagaaatta tatttcttaa 12120ttgcttagaa accgaagaca tacaggggaa atggcatcgt gtcctacact cgtggatctt 12180gaagacatga aacagaccta ataaaataag aatataaaca gacaacagag atttcgtctc 12240tcccaatcgt caggcatttc agtggatctg tgctccttgt gagccgctct acggtggtta 12300agtcaaagaa aaaaagcaca cttcccaggg cgacaacgga ctctctatta gaacctgtat 12360agtttcctag ttttcccttg tttataccta gtttcccatt attatctaca aagatgtttg 12420ccagttccag tccttaatga tccatgcata cattcctctc tgggttctga cctctctccc 12480ttcagtctca cctctgcatc ctgcctaatt gtggcttatc cttcagcttt gccctgttga 12540ttcttgatgc caattcctgg agaggctaat cctcaactct ctcatccctc aaaagaaata 12600aacaaatgaa ttccttccac attctgctga ccataatcac tgaaggatgt gcacagcgag 12660ggctaattgc ttgctggctg gctggttgtt tggttggttg gttggtttgt ctctatctca 12720gcaatctctg attaattcat cgttccctct tctaaattct aggacctgga aaaaaatgcc 12780tgccacatac gagaaattta acaactatat gctagatgaa tgacggttaa cagaactttg 12840tggcttaaat ttgagacaca aaactatgtt gtaggctcta cggatcctta aatgtaagaa 12900ctgggttttt tgtttatttg acttggtttt tgtcccaaca tctctaccca agctctatgc 12960ttggtgtgcc caagcataga gctaggagac aggacacttg ggcttgaatc ctggctgcca 13020caggtctttt gatgacctca gataggggat gcgtcctctc agatggacag tcagctacat 13080agaagcagaa actgacaagg gactcaagga ggaagctcca acttgaattt cagcctaaag 13140gacagtgcaa tgagtatctc ctggattccc agtttctggg accatgtgtg ctccccacac 13200ttcttggaaa tcatctgttg atgaatctgg cttctccact ggagtatgag cccctgataa 13260tgaaggctga gtcttgttta cctccaggcc tgcacatagt aggcacataa

tgaacagctg 13320cagacaagct gaacttcaaa catcatttga aggagagtaa agtctgagtc agatctttag 13380tatcagttgt ttcctgttaa aaataacatc ttttatttga aaaactgttt caagattgtc 13440tgccagggta aaagtcaagt caagttcctt gctgttccca gtgtaagaat aacatgagta 13500aaattcacag tataacccgc tgggactctc agaaatctcc ttgttctttc cttaaggctc 13560atgatgccat agtaaagact atgaacaacc aatccatgaa ttctattaca aaactaaaaa 13620taaacagggc agtgctgtgt aattttttaa aggcactatg agtataccag ataaatagtc 13680tttgttggca gtaggaataa aaacttccaa tactcctgca aagttataag caaaatttgt 13740tagcttcatt ttttttattt tgcagagcaa ttctattatt attgaatagc atgtgatgtg 13800gtttggctct gtgtccccac ctaaatctca tctctaattg taatccccct gtgtcaaggg 13860ggggacatac ctggtgggag gtgattggat cacagaggag gtttcccaca tgctgttctc 13920atgatagtga gttctcatgg tttaaaagtg gcagttttcc ctgcacgctc tctctctcct 13980gccgccatgt aagacttgcc ttgcttcctc ttcatcttcc accgtgattg taagtttcct 14040gaggcctccc cagtcatgca gaactgtgag tcaattaagc cttctttctt tataaattac 14100ccagtctcag gtagtatctt tcaagcagtg tgaacatggg caaatacatc acgccatgat 14160gataattacc gtttttaagt gcttatgcct gttaagagct gttttactca tattacctca 14220gtggaactct cccattcctc agtaaggtag ccactggtat cacctctatt tgacaggtga 14280tgacacctgt acacagatct ggtaagtgtg aggattgaaa tttaactcag gctgtcttgt 14340cctagcactc ccacctccac atgaacctct tagcactgcc acaataatca aagcacagct 14400gtcagagatg gcaacccagg gcaagatgat ttttttattc tacattttgt atattgaacc 14460tttagagcat taaacagtaa atgccagagc ccaacttata aggtctatga aaaggtcaaa 14520gtctcctttt acttcatcac cactggagaa aaacctaaac aataatagta accaaagtcc 14580atgtcttctt ttagaagacc aaaattttga gttcctctat tatgagtctt tgatggagac 14640ctgcttaatt ttctttctgg ggatttacaa caaatctatt tttttttaat tcttcattct 14700ctgtttttgt aatggtttta agggataatt actatttttt taaaaaaact taatgagtta 14760cagaacagtg atctctactt aaaattttgg tacactgctt tcactggtaa cagtatgggt 14820tcgtgctcca accccagctc tgccacttac agaacactgg ggacctgggc caagttattc 14880aacttctctt tacctcagtg ttctctgtaa aatgggaata acaatagaac ttctggtatt 14940aggctgttat gaggattaaa aaaaattcat atttacaaat tgcttagaag agtgcctggc 15000atataataag tggctctgaa ggtgtttgtt ggataaaaaa caacttttgt ggtaattttg 15060ggctggagga aggacaaaca agcaaacgtg ctgagccgag aagactcagg ccgcacacct 15120cccgttggtg gtgcacatta tagatcctgc cagaactgaa gagagaagct cacacaatag 15180ggtgaaaagg ctgggcttga agtaaggttt tgctagggag aatcagatta gaactgcatt 15240tcagaaaatc tgatctggca gggatggatt ggagaaacaa aaaactggag gtagaaaaga 15300atagccagga gttagaggta caacccatct gtgaatcaag ggaacccaaa ggcagatggg 15360gttggaatga gggtgaaaca gagagaaggg aatgggaggg ttggggggag gcactggggt 15420aactctcagg ccgagaattg ggcagcaagg gctcaaggct tctgcaagaa acaggtaaaa 15480ggggagctca tttgaaagca aggttgagtt caaatgcttt gaatagttta tgtcaaaggc 15540aagggtgggg gttcaggtgg agatggatac cgtgcagttg aaaacatgga ctagggttca 15600gcagtcagag ggattaaact ggggatgtgg aagtcgtttg cctagaatga aagttgacat 15660cttagaatgg atgcaattgg cttagattga ggaaagacta gatgagaaaa gagggttaag 15720ggaaaagcct gagagaacaa catttagggg ttgggaagga gaaaaagaac cagtggaagc 15780aagagagatg aagcaaaaga gcctcaggat ggagctttcc ggaaatggag agtttccact 15840gggtcagact ctgcagaaac tgcagaggct aatagattaa gaaagccatc agactgggca 15900gtaatgtggt tcctagtgac actcagcaag caacgtcagt cattcaagga gatggggtga 15960gtagatgata agaaagtaga taaatccaag cttcccaaac tgcagaggat aggcctatgg 16020ttcccaaact acagtggata gatctatggt tcccaaatta cagtacctag ttctcatagc 16080tttttacggg cacgcttact cccacaccca tctcactggc catgatttaa tcagaagacc 16140acaaataagt gtaagcaaga ctaggagatg cagcctttat cccagatgat gacgcactca 16200gctaagcact gagaattctg cacctaggaa ggaaaacgga catctggtag acctcagctt 16260cctctgcctc atgttgggac agattattta ttaagaaatc caaaagctag gcatggtggc 16320tcacgcctgt aatcccaaca ctttgggagg ctgaggcggg cagatcattt gaagtcagga 16380gttcaagacc agactggcca acatggcgaa accccgtttc tactaaaaac acacacagaa 16440aattagctgg gtgtggtggc acatggctgt aatcccagct actcaggagg ctgaggcagg 16500agaatcgctt gagcccagaa ggcagaggtt gaagtgagcc gagatcgcgc cactgtactc 16560cagccctggc aacagaacaa ggctcaatct caaaaaaaaa aaaaaaaaat tccaaccatc 16620aatgggcagg aagggataag ggattggctg taaattgggg gatggcaaaa atcaaaagtt 16680agtcttttgt tttctttttg cttttttatt gttttgtctt ttcctcataa tttgggatct 16740gtctaaatat ataggtaaaa caacagagaa acacagcagg ggtgctactg agaaagattc 16800ctaaagagat gggaaggaga aactccaatc caaattccat acatgcaagg ttatttttta 16860agtcttgaga acagataaag taaaaagtgt tgctttgata gactagtcag aaatttaaag 16920tttctataca tgcagaataa tatatcatat ttgtttcctg acccttctat aataaagtac 16980cacaaactag aggcttaaat gacagaaatg tattgtctca cagttctaga ggctagaagt 17040ctgagattca ggtgttggat ctgccagaca gcatggctca cacctgtaac tccagcactt 17100tgggaggcca aggcaaacag atggcttgag cttaggagtt caagaccaac ctgggcaaca 17160tagagagacc gtgtctctac aaaaaataca aaaattagcc aggaatgttg gggaacactt 17220gtggtcccca ctactcagga ggctgaggtg gaaggatccc ttgagcctgg gagccggagg 17280ctgcagcgag acatgattgc accactgcac tccagcttgg gtgacagagc aagaccttgt 17340ctcaaaaaaa aaaaaaaaaa gtcaccggat ccttccaagg gaaaatctgt tccccgtgct 17400ctcccagtgt cttctggcct tggcctccct tggcttgtag gtggctgtcc tctctctgtg 17460tgtcttcaca tcatcttctt ctacaggtgt ctctgtgtcc aaattttccc gttctataaa 17520aacatcagta atattctact agaggcactc taatggcctc accttaacca tctgcaaaga 17580ctcaacttct aagcgaggtc acactggtga gtgagcatgg agagttagga cttcagcatt 17640ttgggggaca caattcaacc ccttaattta agaacagtta tgacaatgtt tctatttaaa 17700aacaaattcc attgttatat aatttcctac ctaatgctat aaaatcccca atttcattca 17760ttgaggttct ctataaaaat ttaaaatgta attaatactt ctgtacttct gtcaaacatt 17820ttatatattt gctttggaaa gtttccttat ccatatacat ctgaacacaa attggcaacc 17880aattttacta aagccaattt tacataagga cagagaaatt atgttaaaat tcaaggtcaa 17940cattcaaatt ctgaatctta atcaagagta attatgaaag caaatgttat gtatcacatg 18000gaaagctgta taggaatgta cggagcagct ttattcatca tcacccaatg gcccaatggt 18060ggaatcagcc caggcatcct taacagctga ttggtgaaat aaaccatggt acctccctac 18120tgaggactgc cgttcagaaa cgcaaaggaa ccaagtacta atacaacacg ttgaatgaat 18180cttcagaaaa ttatgctgag tggaaaaatc taattctcaa agatgacata tgattctttt 18240tttgtaacgt ttctgaaatg acaaagtttt agaaatggaa gacagattac ggtacccaga 18300agttagggat gggggaagtg gggtgagagg gaagaggcta tggaattgtt cagtgtcttg 18360actctggtag tgaatataaa aacttacaca ggagagaagt ggatagaact taacacacac 18420agagacacac acatacacat gcacacacgt gtgcacacag gcacgtgtac acacatgcat 18480gtgcacacat gtatacacat gcaggcacac actcgcaaat acacatgcat acacacacac 18540acacacacac acactactgg cactactgag gaaatctgaa taaaatcagt ggactgtgtc 18600aacgcccata tcctggctgt aatagttcca ccatgttttt gcaaaatatc accatggggg 18660caagtgggta cctcaagtct ctctgtatta tttcttgcaa ctgcaggtga atctacaatt 18720atctaaatga aaataattat ctaaatgaaa agtcaattat ctaaatgact atttttgtaa 18780tgaaaaatag tcatctcgag ccttggcttt atgtattatt aaacctattt attttgaaaa 18840caatttttat actttttaac tacagagctg tgatgaaatg caatacaaat attataaata 18900ttattttttt aacacatcaa ttagtcacca caaagacaaa aagcagagtt aaaaggaaaa 18960gtcaaagagg aaatgctatt ctaggaaact aaaatagcaa aacaacatcc aggtagatta 19020gagatgagaa agaagactaa agagaatcca ctcagataga tagatagatg atagatagat 19080agatagatag acagacagac agattaaata ttaggtactc tggtccttga ttgaaaacta 19140agattcaaag ccatttattg tgggttcata aatctcccct ttataataaa aactctacct 19200cattattcaa ttgatttcat tatttctagc agacttataa aggctaaaga aaaaagtagc 19260taatgttgaa aacccacaag ccttatttac aaattacatt ccaaatagaa attcttttcc 19320atttatgcct ctgaacaatt atcatattaa atgcaaactt tgctcacctc tctctgtatc 19380tgaattgtca cattgtctca atcaggttca gcctgaccac cctgcttaag attgccctta 19440gcgcatcacc catatctttg ttttcctgtg tgtacaatat ttatgatatt ctaccatact 19500gcattatgta cttattatgt ctatagttta ttatctgtct tcttcttcca gaatataagt 19560ttaataaggc agggattttt tttgaagggg cgggggaggc atacgttaat gtacctggaa 19620catagtaggt gcataatcaa tatgtatttg ttgaatgaat gaattttagg cattctatgg 19680tccaattttc agtgcaaact ttttaggtag agactaaaaa aggaaataaa actgtgtgta 19740acttcttgtt gttgttgcca ttgttgcaca gacattgttt ttatggcata aacactcaga 19800ctgaggcaag aacaaaggag tcgaccttgc catccctaca ataaagttcc taagcaccta 19860taatgggaaa aacagtgtga taaatgttga aaagtatttt aaaaaaccaa gacatggtca 19920tgttcttggc agtttacagt ccagaaggaa tgccaaaaca catccacaaa taccaacccc 19980accagctata aaatgatcaa taccataaga gagatatagg caaattctac caaaaaaaaa 20040aaaaaaaaaa aaagagctga ctcctgagtg gagggcatct gggactggat ttgaggatgg 20100aatagcactt cagtttatgg agataaggta ctttctggga gggaaccttg tggagaagct 20160gaagcctcag cccatatggg gagctttgat tggcttagga agcagagatg ggacacgaaa 20220ggggaagagg taataacggg tccagatgag aaggtccagg gactaaataa ggaatatcgt 20280acatggtgaa gagccaagac ggtgtgcagt taactagaaa acacagaatt acacaatagt 20340gctaattgta acctatgaac catagagcca aggttcagca atgggggcat gtgccattag 20400ggcccagagc agtggtgctg gttgtcatgc tcagaagcaa ggcaagggtc tccaagctac 20460cttctccaag cagaattgtc tccaggtgtt ttatcagctc ttcccctgcc ctcatcagac 20520aaggacatca atgatggtct gtgtcgtgga gaccctacat acttcctgga tgtattgggg 20580ttagatgtga tgggtattaa gggtggaaaa cagagttatg tattcacaac ggagttatgt 20640attcacatga gatgtgtttg ctgtaactaa ctgcacttgg gttccatcgc agttcaccat 20700ctctgtttat ttcccgatag agttcaaggc ttaggctcag tctgcaaagt agaatctacc 20760tggctgttca gatgatgagt agctggggca aaaccttgtc ttctggatac tttaccaact 20820ttccagccag cttctccacg aatcccaaca ttgcacacaa gtgaacatgt gtttccaaac 20880acaaggatgg actgtgttga ctgcccatcc tctccagcca cctgtccctc atcctgcacc 20940agggcatgct cttgtgaaac agcacaccaa ggtcaggggg catggcagag ctgtgagcag 21000gaccagtggg agcgccacat tccaggcaca gggcctaaac aatgacattg gccacttcgc 21060ccacatcctc cttttggcta tgtgcgatgc aaaaacttaa acaagtttct gctttaaatt 21120gtaaatgcaa caaataaaaa catttatact aggcttgtat tccagagtat tattttgtca 21180tctttttgtc aacattttaa gtaaatttca gtaacacatt tttccttttt tataatcatg 21240gctgattgcg ttttttttgg gggggaggcg ggagacagag ttttgactct tgtcaccggg 21300gctggagtgc aatggcacag ccttgattca ctgcaacctc cgcctcccgg gttcaagcaa 21360ttctcctggc tcagcctccc tagtagctgg gatcataagc atgcaccacc acccccagct 21420aattttatat ttttagtaga gacagcgttt caccacgtta gccaggctgg tcttgaacta 21480ctgacctcag gtgatccacc cacctcggcc tcccaaagtg ctgagattac aggtgtgagc 21540caccgtacct ggccctgatt gctttttata cataaaaaca gaaaattttt aaaattagat 21600caacatacag aaagagcttt aatttggaaa gaatttccaa attgttctaa taactccttg 21660tataacatga aaaccagatt tataccataa caacgtatgt atttgttcat tttggggatt 21720ttggaaggaa aggggctttt tccataatcg tatgtcataa tcattgtcat cacccactga 21780actaaacact taccatgcaa tagttatttc atgtcttcct catagatgtc cgggactgat 21840gatttattca tcttattttc cagctgatgg aaatgaagtt tagagtggcc aaacactgcg 21900attacatagc tgacaaacct caggtttatg attccaaatt ctatgctttt ccccaaacac 21960tgcattcttt gcacatagcc agtgctggtg tgtacacaca catacacata agcacagagc 22020ctgcgaagtt ctgaacacca agcggttcac tttagtgcct cctccttttc ttctacaagt 22080tacaagctcc ccccaacgtt atttcaagca gagggtactt cagaactaaa acagtatctg 22140acagtgcctg gctcaaacac ttccaattcc ttcctagagt aagtaggaaa gcacagaaaa 22200ggataaaaac acaagcacag acaggtggac ctgtcgatcc acaaaccccc tgccagactc 22260tgggagatgc tggtgacagg aaaggacagc agacctggac cgggaaacac aatccacagc 22320cttgtgcaga ggctggaatg aagtgcgcag gcggcttgag ggaggagccc cacacaactc 22380tccttaccta ggagctggct cacctgaccc actagagcac agcaactggt tttgtgaaag 22440aaaaaaagaa aagaaaaaac agtgataaat aacataggtt caattgtttt gacagtaaaa 22500ctcattccaa aatacagcag aggcgtgtgt cctccacgtc tcgccttccc cacagagtga 22560gcccttcatc tctccaaggt cagtctgttt ttagcccaac gttgcttgaa cctgtcatct 22620tccctccaat tgcaccatca ctgtcaatgc tcccaccatc acagtgctcc caccatcatt 22680agccctccct tggcttccta gaaaggtcac cctgctttaa tcttgcacta ttttaatgag 22740ttctgcactg aaatcaagag tgtcttcaca aataccaacc tgagtctcct ttcctcatgc 22800tcccatactc atgaggggct ccaccaatgc caacacgtgc ctcctttccc catgctccca 22860tactcacgag gtacaaagcc catgctcacc ttttttacct ccctccctcc agtccacacc 22920tggccatctt gtcctccccg agcttggttc agctaaatag tccctgaatg catcaagttt 22980gttctcagcc cctcactcat gagctttctg ctccctttct ctgcctagaa tgttcccatt 23040ccctcggtcc tccttcactg gacttactcc ttttcatcct ttcagatgta gctccaggaa 23100aacctcccac cacccgtagg caaagtcaga gtgctttctc cactgcagtt ctgaagacat 23160tccccacacc ccatcacaag cacagttgag ctgtgatcag gtgctcatgt ctcctctacg 23220gtaaactcct ggtgatggct tcggtcattc cttcaaaagc tttttatgag cccctatccc 23280acagccagca ctcccaacat acagcagtga aagcacaggc tctgtgactt cgatgctcgc 23340aaataggcaa ttgtataaat aaacaagata attgctgaga atgatggatg cttcacaact 23400gtagcttttt cttttctatc ccccaagatc caaccccatt tttgacattt aaaaaaaaat 23460gctcaataaa tgtgttagat gaatataaaa tggcaagtac catcgtgatg acggtaataa 23520agttttgagt gtagaaaatg agtgataaac agaaatacag agaggaggag aaggaggaga 23580tgaaggatta aggagaaatt taacattgaa ggtttagaga aggttttttc ttgacttttt 23640aagacagtgg caaaagggta gaaaacagag ggaagatgac agattcgttg atacattgat 23700aggaaaaaaa gcagtattga gtgccttctt gaaaagcaaa aggaataact tctctgatat 23760gagcttaaaa caggtatgtg aacaggtaga aatgagttgg tagaaaagta acctgaaagt 23820tgagggggtt tgtcctgatg tatctgtttc ctttaaaaag tcaaaatcac agttgggtgt 23880tcagtgtgga gggtggggaa gggataaggt aggagttggg ggaaaatgaa aatggtgaaa 23940gtatgcaatg accgttgtag gcaatgggaa aggcagcttt ctagaagctg aaacaggaca 24000cccctccccc cagcccctgc cagcagcatc aatgcagcca catccctggg tataaactct 24060gtgacttccc atggaagagc tctacaagct gaggtgcaga gagggaacac tcgctaccaa 24120gaaaaactca aagcctgaca ggtctttggg tcatgaaagc aaataaacca caacaggagt 24180tcacgtcttc agaaaatgac ttgtgctggt gtctaatgat gcctggggct gtggggtggc 24240aggtgcaagg tcagagccaa aaatataatg cagtttggaa gttttgctcc acaaagcgaa 24300gaagagtcat tagtttcaac tccaccaagt caggcaaaca cagtatataa gatcatttga 24360ccctgcttcc agaacgattt ggcctaaccc agcagcctgc agttctccga cttatctcca 24420ctgtataaaa tatttcctaa tgttttatga cataactaat ctgctagcac tgggctttgc 24480tcacacaccc aggatcaggt caatccacct gtgtaacagg gcccattcca ggacacacct 24540gtcatcgccc caaatggtaa ccctcttagg caccccaaga ggaagtgagg gatgggacac 24600atctaggtca gacctcagca gacatgatta aaaagagatg tgtagttgga cagacagctc 24660gcacactttt gaaaatggca cgcaggagaa accaccttcc ccttggcttc ctcgcattag 24720gtttcactgg atctgaataa atgttacgtg gctctctgtg gcccagcaaa tacaaaggct 24780ggagcattgt ctgtgctggc ctcagtcacc gcctcccttg gaaaaaccaa gtgtgaggca 24840gagacattgc tcctgtggga aaagcaactt ggcccacagt caagtctaag tttgtaattg 24900gagcaggaag gggtgggtgt gttttcagca gaggcaggtc aactagggaa aaggtgatgt 24960ttacttcggg gctggggaaa gcagatttgc tgcgtggaaa gagctgaaat agcagcaaat 25020gccaccgtgc ccgtgcaagc agctccagcg aagaaagaca gctctatcgt gtttaggcga 25080aaggggaaag ttaggcaacc gtttggaatt aaaaaaaata aaatccggag cccactaagc 25140ctgtgtcaac gggcgaaaat gaagtgaagg gttgagaaaa tgaactgggt atggcagccc 25200caagtccacc atgggacagc cacctaaggc tggacccggc ctctgtgcag gttagaaatg 25260cgaaaactcc actcagaatc aagcttggag caagcctcac atgcccagca ggggagaggg 25320tggaaggagg agtgggaggg agggagaaag gaaggaagag gctatgtgga tttttaaaaa 25380tccagatgct agtgtagaag ggatcattgt gctttctcca ttgatttact tatgcttctg 25440gaatttgcca ttcactgcat aattgcaacc ggaatgttat ggtgctcttc attaaaaatc 25500tcttggagca agttgagcct ttattggagg ctaaatataa atgttgttgg accaaaggta 25560cagcggtaaa tctggacttt tgtgtgtaca gtgtaatgtt gtggctgaca ttttggggtg 25620tgaccacgtg gtcaaaatga actgaagcac tgaaacatta tttgggacaa tcagatcaat 25680ggaaagagct gctcttcatc ccacaggaga aaacaaagtc ggcttaagta aaacctactc 25740ctccttattt tctgtagcac atttatgtgc ataaattgtc ctgaaataaa gaactcaaat 25800catatttttg attgtcccat aaagccagat gtctaaacaa gggttcttaa aattacttag 25860ggaatgaaac atcagaaagt tacgaaacat gataaaatat caatgtttac ctctgttttt 25920tgaactaggg ttattttagc gattaaaagt atggcaacat taaaatcacg caatacaaat 25980tcacaactat gagcacagct gtccatgaaa atccagctgt caggctaact caggtagcta 26040tttccaaggt actcggttga gagtttggta cttgttcact gtttttctta tcaatttaag 26100tgctttccag cagagaagca gtagaatttc caaagattta agaaaaagtt attggggaac 26160tttttaaatt gaaaaaagcc tatccctttt ctcaaccttg tatgtgcacc tggaaacgat 26220cattatctca ctttaatagt aaaaccccag gttcagcctc cagagtacac gttttccaca 26280ggaatcaagt tggagaacca tcgtcctgtg atgtttttca cttcccatgc tctgtcttag 26340actatattag aaatgtattt ttagaataca gattttctgc tacaagaatg aagccactct 26400tatttttctc tttgctctga tttcaggatc tatttttata ttattctatg tacattttat 26460aagacaccaa agataccctt ttgaagaggt ataaataagt tgcttaaata caacacaaac 26520aaaaaacaaa cactaattca ctctaaactc tggagtctag aaatttagca tttaaaactt 26580ctatttagtc atttatgtaa tcattcattc agtgaataat taaagcaaac taattctact 26640ccaaacattg gttcagtcct ggttattaag cacataccaa ggatgctgga catagtaact 26700cacacctgta atttcagcat tttgtggggc tcaggtggaa ggatcactta agcccaggag 26760ttcaagatca acctgagcag cacagtgaga cccaacaaaa aatttagaaa ttggagctgg 26820gcacagtggc tcacgcctgt aatcccagca ctttgggaag ccgaggcggg ctgatcacct 26880gaggtcagaa cttagagacc agcctggcct atgtggtgaa accctgtctc tactaaaaat 26940acaaaaatca gccgggtatg gtggcatgca cctgtaatcc cagctactca ggaggctgag 27000gcaggaaaat cgcttaaacc tgggaggtgc aatgagccaa gactgcacca ttgcactcca 27060gcctgggcaa cgacagtgaa actccgtctc aaaaaaataa taataataaa ttaaccaggc 27120attgtggtgc ccacctgcca acccaactac tcggaaggct gaggtgggag gaccacttaa 27180gcccaagagg cggagtctgc agtgagccgt gatggcacca ctacactcca gcctggacaa 27240ccagggcaag actctgactc aaaaagcaag aacaaaaaaa aaaaacaggt gcctggtcac 27300agagaattta cattctggaa gggataaaca ggagataaac aatgcaatat gcatttaata 27360aaataaaatg tcagatgcta gtgttattga aaactggcag gatcaagggg acagaaagaa 27420aaattcttct tagagtggta agggatggcc ttgcagataa agtgacattt aaacgggaaa 27480ccgaaagaaa aattcagggc aaagcacaca gctatctggg acaagagcat tccaggaagc 27540aggaagaggg accagcaggt gcaccggctc tgggcagggt ttgctcttta accctcctag 27600aactaattgg tccacaaagc ctttgtacct tttacacatt taaatagcct ccaaatgact 27660tcttttatga gataagcaca aagtcaaagt cctttggatt gaacatttct gtcttttcaa 27720aattccaata tcacctctac cagaaactcc tgttggcttg atctcagatg caagtttcaa 27780agcattctct ttatggtttc cactaattgt gctcttattt actttccctg caccagggac 27840aaagaaagat gagctcctgt ggtgttggaa attcactgtg acttcgggca gaaggcctgc 27900tttgagaacg tacctaattc ctgccaaagc tcatccctgt atttcctcaa aattgttggc 27960gggtttctca tttgaccgag atttctttga aatcaacagc caggaaaaac aagtaaacaa 28020gcaagggcag cctcccaggg tcacccacac ttggtgaaca gtagccagga tgggagcacg 28080caggccgcgt tgtcctccgc aaaggcctgg gtttccatgg tgctaggtct gcaaagggca 28140gtgttcaaaa tcaagccact gcgtggtgaa actagcaccg caaaacccca aatgctttgg 28200gtgttggttt tacaaaggat ttacactatg tcgtgggcat agaggttcta cctgatcact 28260ttttggaata actccaggat gctttccatc tctcactaca aatctcacat cacctctctc 28320caggcctcag ctgctgtttc tcctaaaaat atggcagtgg gaggggatgg

ctgagccctc 28380tgaagtttta ctaatatcag ggcgcaaaca cttgcctcga aatgacttcc ttctcctgtg 28440caataacaaa attaataaaa gctcggtggc cactaccaga tagtgacttt ttcatagaaa 28500tgtagagaac atcaccataa tccttgtcca actgtgataa ctccaacatt tatattaagt 28560taagtgattg aggtctgcag tctttgcttg ccatagtcaa ctgtacagca atatatttta 28620tttcctaatc atgcccccag aaacccctgt ctggaatatg ctattggaca gaggacataa 28680tatgcaaata catcttatcc atcataaaac caaagctaag gctggaagca aaaaggacat 28740ttgtttgcaa ctcagctctt ctcttcagac tccccatttc ccagctcatg ttcctctgag 28800tgcagcgtct gcatctcacc atcagaggga aaacctccac gcagcagtgt ctttaactgt 28860ttgacttcat tgcttttcaa aatttttctt aaatcattga aaatatctta gaagtcacag 28920taagaggtag aatgggcttc catagcatct aatgttttaa ttctttaaaa actatctgag 28980gcgaatgtgg caaaatgcta agatacagca aagctgagag gtgaggactt gagtgttcct 29040tagtctgtct tttcgcatgc atatatttaa caataaatac ccaatagtaa tagatattta 29100ctaatgaaat gcattagtga aaacatccct ggatgttgtg acttcaacta attgatagag 29160ctaaatatat ctgcatactg ttttcatgta cagcatttgc aattcatgtt tagacttcct 29220ccctcctctc cccagaagtt tccaaaaggc aggccacgta attgctttac attatggtat 29280ctattttttg ttaattgatg tcttcttgtg gcaggacctt tcttcccgct atcctgagac 29340tcagcagctg cctgtgggca tgtaacccag tggaggccat cagctggtgt ggtccccagt 29400ctcagtgagc aagggctgcc tgcagcctgg ggtccatggg ctaaggccct tagctgattg 29460cacacagact caccagggct tagacacaaa ggagatggat gctgaatatt tcacctgagt 29520gtcacctgct ttctgttttc tttttgaact gccctagaaa tccctcctca agaaaattca 29580tcaaacgaaa ccaaagcagg gtatttctgt cgtctcttct gcttagtact gtcctcttta 29640caaattgtta gttgtctcaa cattacatat gagtctactt tagggctgtg aagtatatta 29700ttcaacattg atttttcctt ccttcagcac tggcgaccct ggatcactgg ccactgttta 29760aatcaccctg tgctggcttc ttctgagccc gttagcacca tgtggtagcc ccagtgccga 29820tggcatccca gcctgcatcc aggtcagagg aggcgcatgc ttccgtcacg cacgggcaca 29880ctcctccacg aagaacccca gttcaccggg gctgccctca tgccataaaa acagaggcac 29940tgccggccgg gcatggtggc tcacgcctgt aatcccagca ctttgggagg ctgaggcggg 30000tggatcacca gccaggaggt cgggagatcg agaccatccc tggctaaaat gtgaaacccc 30060gtctctacta aaaatacaaa aaattagccg ggcgtggtgg cacatgtctg tagtcccagc 30120tactcaggag tctgaggcag aagaatggca tgaacccggg agacggagct tgcagtgagc 30180cgagatcgtg acactgcact ccaacctggg tgacagagtg agactccatc tcaaaacaaa 30240aacaaacaaa caaaaaatac gaaggcactg ccattaggac agagtcagag agagccacac 30300acctgacatg tggcctctta agaggacaga gacgtgctct gctggaagaa ggaaaacgtt 30360agaagaggtc agttgccttg cctggccaca tcagtccagt gtggactgat atatatctta 30420tattccaatt tctttacttt tcaaacatgc ttttagccca gcacagaact gtgtgtctct 30480ctttacggca gggaggggaa agtgcaaaga tgagatcaaa atcaaacatt tcaagattgc 30540gaggaagagt tggaaattgg tacttttcac ccttctcttc ccctaaagtc attctcacct 30600ttccctcagc tcacaggcga aaggagggta cctgacaatc ccctcaaggg gaggttcagc 30660agatacaaat gaggactgaa caaaatatta gaacagttca aagaaaaggt gactgcaagt 30720tggaaatcat aaacatcacg tgttcataca ttacatactc atgcaccaat atttgcttta 30780aggataaagg cttttcttaa aaatggatca gggccgggca tggtggctca cgcctgtaat 30840ctcagcactt agggaggcca agatgggtgg atcacctgag gtcaggagtt caagaccagc 30900cttgccaaca tggtgagacc ccatctctac taaaaataca aaaattagcc gggtgtggtg 30960gtgcatacct gtaatcccag ccacttggga agctgaggca ggagaattgc ttgaacccag 31020gaggtggagg ttgcagtgag ccaagatcat gccactgcac tccagcctgg gcaacagaaa 31080tggatcagtc gattagagtt cggcacttat tattattatt attatttggc atacataaca 31140ctgaaagtgt ctattcctaa attctagttg agatgtcttt cagtaactta ggaagccatt 31200gggaaacaat ctgaatgcaa actttttcta gagtttttgt ttgccaattt ttcacaatca 31260tcacatctag gtataactta acagagaaaa gtttgtgact cgactatact ctttccaaag 31320ttttaacttt acaaaaaaca gcttgatttt cccctaatag ttctttatta tgtatgcatc 31380ccatatatgt ttatatatgt tcaagtgtac aacaaaaatt cacaaaatac tataaaggat 31440gtaccttgtg attttccatt ctagcccaag gaagttgagc cagttctatt ctttcaaatg 31500cagaccacga cccattaaat tgatttaaca acctgcaaat agtcaggctc cccagcatga 31560aaggcactgc ttcagtagct gtctgtaagc accaagcagt gagggcagag aggagaaccc 31620ctgagcacct ccccatacca ccgactgcat ctcagtgtaa tgtcccaata gctcagagga 31680aacatagcaa atgcttaaag tatcaacact actgaaatca atgatgtaat ctttgaactc 31740acagttacac ttgtctttgt tttgtgaaag catacaaatg tcttgttctc catcaagaca 31800ggaaaagagc acacagacag cttcagtgcc tgctcctccc tgtgctcaag gttcactcca 31860ttcttccaat ttttttcctc taagttcaga ggctggcaaa ctgcagtcca tgggccaagt 31920ctggccagtg cctgtttttg tcaaattgcg tcggaacaca gccacgctgg atttgtgtgt 31980gtgttgtctg tggttgtttt caagctgcag cggcagagtt gtttgatcgg agaaggtctg 32040ccacacaaag cccaagacat tcacgaactg gccgaaaaga tggctcaccc cccgcactaa 32100gtcatctcct agctctgaga aaatggcgat cctctgagaa ctcagaagct ctttccccat 32160attaaattat ttgctcacaa acttgtttac tgggataaga agaaggtggt attatttcca 32220ttgccattta tgcatcagag caaacaaatg atcaagtcag acttagagat aggacatatc 32280ttacaggttt gaaatgaacc ctttccactg tcttagttta ctttgctttg tttaccacag 32340taacagagga aagaaatttc agggccctgc aaccatgttc atattttttc atctcatgtt 32400tagttctaaa gatatatgta atatacgcat cacactttat actgtagtta tgtttatatt 32460aaaatacttt aaattgctta ccttcaagta aaacttgtgg tcccagaaaa ctcagagctt 32520caagaaacca gtgacattaa atagagccat atttcacctc aaagtgccat accgctgttt 32580gaaaacatgg aagaagaaat ggacatcacc aggaattatg aggaccacct catgcccact 32640gagggtgttt ggggacagca gctacctggg ctgggatgaa gggaatggtc ttgcctgggg 32700tacagaaaat ttctgttaaa agataattca tacacgataa gtaagccaag caaaactggc 32760ctgcttttat cccaacaaga gagtcattcc aaacacagtt agtgatgaaa cagtcctaca 32820cacacacaca cacacacaca cacacacaca cacacaatca tttgttgatg aaagttctaa 32880ataattgctc ttgtgactgt tgagttttca ttacatatat ttgggtgtgt gtgtgtgcgt 32940gcacgtgtgt gcgcgtgtgt gatgggttga aatgcatcgc ccaaaaagct atgttcaagt 33000cctaacccct ggtacctgtg aaggtgactt tatctggaag tggggggtct ttgcagaagc 33060aatcaagtta agatgaaacc atactgaagt atggtgggtc cttcatccaa agtgactagt 33120gtcctgataa gaagagggga agaaaaccaa gacaacacaa gagaatgtgg aagatgtgaa 33180catggagcag agatcaggca atgtgtctga gagccaagca gtaccccgat ggccccagcc 33240accaccagaa gctggagaga ggcagggggc cgattccttc tcccagcctc caaaggaacc 33300agccctgcag acctccagcc tcgagaacca tgaggaatac atgtctgtta ttttaagcca 33360cacagtttgt ggtcatttgt gacagcagtc tggcgaaact tatacaccta tgcaagcttc 33420aatcaattca tttgtatctt tatcacttaa taaacatcat actctacagg aaagttattc 33480cagaaaactc caagttattc agctgaccct ggcacacagg cacccagccc cccgccttca 33540tgtgaacgga aggagctgga tggagtaaac tattaacact ggttccaggt gcttctccaa 33600ccccggggat aatacatatt ctcgcactta aaccttagat tctaaattaa acgtgacagg 33660acagtgcctg tcaaaataaa ggaacacaac ttgacttatt ttaattcagt catcagaggg 33720gaccatttgg aagtttgtgc ttaaaatcta aaacagtgca acaggggaca aactgcacaa 33780tgtaatattt ttgtttagta aatgcaaatg tcagttcata aaacatttta ctgaatctga 33840aaaatttttt taaaaataga aatgtataat tttaactgat ttctactcat tttaatatta 33900aaagaaatat aaatatataa tatatataaa tataaattta tatataatat ataatatata 33960atatatattt aatatataat atatattata tataatagtt atatataata tatagttata 34020tataatatat atttcatata taatatataa tatatagtta tatataatat atatttcata 34080tataatatat aatatatata tatcatatat aagttatgta taatatatat ttaatataca 34140atatataata tatatattta atacataata tatagttata taatatatat atttaataca 34200taatatatag ttatataata tatatttaat atatatgtta tatataacat atatttaata 34260tataatatat agttatatat aacatatatt taatatataa tatatataaa tataaataaa 34320tataaatata taaatataaa tatatattat ataaatataa atatatatta tataaatata 34380tataatataa atataaatat atattatata atatatatta tataaatata aatatatatt 34440atataatata tattatataa tataaatata tattatataa tatatattat ataaatataa 34500atatatatta tataatatat attatatatt atataatata tattatataa atataaatat 34560atattatata aatatatatt atataaatat aaatatatat tatataaata tatattatat 34620aaatataaat atatattata taaatataaa tatatattat ataaatataa atattataat 34680aaaatattta ataaataata ttaaagaaag tcattactac tactgagtct tacatgatca 34740ttactaaaag taattttgtt acgtgcagga gagaagtgtg gaaaatcatc tgtactgtat 34800atcacatgtt ctgactacac cttagtggga gcagccacgc tgtgagcact ctctcttagt 34860tattcaacta tgcaaacaca tagcaatcaa gttaagatga aatcttcact aggctttgag 34920gttgcagaga tgacacaaac atgcaggcac agagtcctgt taagcaacct gtagtgtgtg 34980cgaacgacca acatgtaagt gattattccg gctctggctc ccaaacctgg ctgggcctca 35040gagtcaacta tgaatcttgt ttaaaaaata caagcatcca ctctcaaaaa tggtttcaca 35100ggctcttatc aaggtaaaca tgcccttacc acatgactca acaattctgc tcctgggtat 35160ttatcccaga taaatgaaaa tatgtcttca cacaaaaacc tgtacatgaa tgtttgttgc 35220agctctgttc ataattgtcc caaactggaa acagctaaaa tgcccctcca aaagtgagtg 35280aataatcagc tgtggctcct ccacacaatg gaatacaacc cagcaaggga caaacatgaa 35340tcaacaactt agatggattt tacaggcatt acggtgagct aatgaagctg acctcaatag 35400gtgagggccg tatgattgca ctggtatgac agcattggaa agatacatcg gcagtgatgc 35460aggacagaat agtgggtgct ggcgtcagaa ttcaggaggg tgagcctata aagggatagc 35520cccaaggagt tttgggggtg agggaattgt ttgtaacctg attgtggtag tgatcacgca 35580aatctatata tgagtcaaaa ttgatagacc tatgcactaa aaagaaaaaa gtcaatttta 35640ctgaatggct gaagggccca tgcagtagtg cataaagact caagaagcag gtggcagggc 35700tgtacagagc tagaaagagg tttcaaatgc attctggagg caatagggaa actaaaaatt 35760tttcctcatg agacagacat gattagatct gggttttagt aggatcattc tgttgacaga 35820ttgaagatgg attggaggtg gttacatgga agagaaggaa gtcaattagt attccatggc 35880aagaaagatc aattaagggc aacagataat gaattcagct ctgtacatag tgagttagag 35940acactcacag ggcattgaag caaagatgtc catgggggtg gaagacagga gtctgaagct 36000ccggaaagag ccccaagcta atagtaacag tatggtagtt gaatgcatgt gtacagatga 36060agttgtcttg gatgaactgt atgtagggtc agggaggaaa aaagcagttt gggattagag 36120tcaaggggaa ctgcattatc tggaaaaaaa gaaaaaaaca tatagagaga aagaagaaac 36180tgataatgtg tagtcacaga ggagtgcttc agaaactaaa ggaagaaaga agaaaggagt 36240caacggtttc cacccctagt gcatgagtct ggatgctatc gtctaactgc acagaataag 36300caactgggct gtacacagaa tcacaaagcc acaggatttg gccaccaaaa gagatctatg 36360tgatcgccca gtccaaaccc tcattcaata gctaaggaaa ctgaggccaa ggaagactag 36420ctggtttgtt tgaggtaaca cagctaatgc acggtaaggc tatggcaggc atccaaactg 36480ccagattgtt ggaataaaac aattgaattc ttcaacaagt cttccataag aaaatttaaa 36540tttcaatcaa cacattatcc ccaccagttt cccttacatc cacttatgag agaaaaccat 36600cttctatccc aacacagaaa agtaagaacc aggatgactg gattcatccc atttatctac 36660ctgttgctta catcagtaga tgccaatcta cctgattaat ccatttactt tcctctttct 36720gtccagtagg agaatacaaa cagattttga actacccata tagctcccca aatttggctc 36780ctagataaat ttatcagata tttgtggtgg aaattctatt tttcctcagc cttgactttt 36840ctgttttcta ttgcaaaata tttctcactt gctactcacc aggctatgga gagactgtga 36900ggcacacagg atttcctaca aaaggggcca cttacccaaa ctttctaatg gcttaacaac 36960tagaacatat aactttttaa aaatcttaca cgtttcaaaa atgtacaatt aattcattgt 37020aagaccaaca ttattctttc cagaagggtt aaatgtcaag catttcagct ccaaattttt 37080ggctcatttg attctttctg agtaaatctc agttaataaa aaaaatacac aatgcaaaca 37140tgccaaaatt gctttctgat ttagagattc cttaagaatt ttattttgca tagtaaattt 37200ggatggaaat ttgtctctaa aaatatagca agaagataaa ctagtctaga actaaagcta 37260tagacattta aatgagtgtg atgctgtgaa aatctttctt ggataagaga aggagtgtga 37320aaagcaaaca aagacggcag atcaataaca tgggaacgag agaaagatct ggcgagttct 37380gaagtagcca ctggaatggg caagagggtt catgagcaaa cttgggtcct ggcggaagtg 37440gtgtgttagc aggacattca tacgtgagta ggtgtcagag gcatagaaga gaagttcatt 37500tcaggataag agaagaatgg gctgtgaaaa caaaaggtat attttggaaa gctcagtgac 37560acacagctca taaataagtg gaagatgagg caggacaggg tgcagacttg tgtcatgttg 37620ccagaatttg ggtatgtctt taaatgcact gagagtgtct gaggttctag aggagcggta 37680tgattctacc tcagcttctg gaaaggggtt ccagcaacag tgtctttgta aagagaccat 37740cacaaaaaga tccaagtgaa ggaaaatggg gcccgaggca gtcatgtgag tgaggagagt 37800aggaaaagaa ggcagagaga aggatttggg agatatttca gagggagaag caagaggacg 37860tggtataggg gaagggtcag acaggtccgt gctagggatt gacgtcccgc gggagaggct 37920gacgttccta cccggcagct gggacagctg cagttatcag cagctcaaat gtgaaataca 37980ggagaaaagg cagcagggaa ggaaggccca tcagattagg gcacggtgag ttctgatgac 38040tgcccagatg tccagagagc ctttggaaat tcaggccttg ccattcatag aatgacatca 38100agatgtaggt ctatcactcg aaatcagcag gtttgaaatt atcagagtgt aggaggtttg 38160tctagacatt tgctttaagg ctttggcagt ggaagaaaaa cccaaaatac actcaggagg 38220agaatatggg gtagggagac attatttttt aataactaat tacaatccct ggcaagagtt 38280ttgctggtaa ttttacttcc tactgtggtt gctatccatg gatgtactat acatataaaa 38340gagataatat caaataactt gtttctgtga catactaaaa gaagaagtat gaaaaatatt 38400ctacctcatc taaaattctg ataccttcat attttggaaa ggcacatacg tattaaagta 38460tacaactgtc aacaatttgt aaatattcca caccaagtgg ctgctaggca aagccttacc 38520ttgtgttgat atgacatctt ttatttcttg agtcctattg caaaaattta aaagatttct 38580cgttatatct ttttcatgtc gctcacactt tccaataagt atgtgccaag cttttattct 38640tcaaggtcaa caaaccctgg cttagccatc ataatcaatc aaactgcatt tttacaaatg 38700taagtttcag ccatctgata aaatgagcaa ttctgcaatg ttttgtggtt tttttatttc 38760cgtttgaaaa caactcattt tagaggaact ctgttccctg tggttcttag tcatccttat 38820cccagaaaag agtaattttt cagtgtccat tctcactaac tctggaatat attgtatgat 38880tagctaactt tgaacctcaa atacttacat taaaagtgca gaaaccatga tggtttgaat 38940agttttgttt tgtgatttag aattcaagta gagctggata ataactgaca acataaaatg 39000tggaatccac aaagagtcag tatgattcaa agttcaccat tctaattcaa ataaaatttt 39060aagaattaaa actgatgtcc agcccaatat agaagctcaa gcaaattcaa atggctgatg 39120gaggagctgg cttggctcca atttttctat tcctcaagtt acttttgaga aaaataatac 39180atataaatga aaacataaca ttactggaaa agagaaaaat gaaaatagcc atggaataga 39240aatgttgaaa gcttcttccc aagcaagcct agaaaaagct ctgagagcaa agtcaaggag 39300gcaaagacct tgccatgagt caaacattag ggcgagagct ggaacggctc actacagctc 39360ctaccaccaa tcccccaaaa tagagtcgaa aaatgacggt cggagaaatt gtttctccca 39420aagacaaagc ccaaagacta gtttttaaag aaaattaatt tgtcggtgaa cttacagggc 39480ctaaaagaag cacagcagat cttcgccccg gcaaacccac aggggcgctg tggagtttct 39540tcatttttga gagaaacaca acctcttgga catccatcag cccctccatg aaacgtctgc 39600tctagcaaag ccaccgatcc aaggctcaag agcgctactt tactttccac gaggccctgg 39660ctggatgttc agcaggtgct ctgataaaaa gcaggccccg tatgaaaacc agcagggaac 39720agaaaacgca gcagggctct ccaatctcat gccaaggtag gtgaggctgt gctgtcccca 39780gcaggcgcgt gcagcgctgc taagtgatgg gaatttcaga gcaaaagaaa agatgggttg 39840ttttttgttt tgttttgttt ttgtttgttt tttctttaaa ggtatatgta ttggtttttc 39900aaacagttac taagttgtta gggcatgcat aattatgtcg tttggctcta actacttata 39960cacagaactg ttaagaagtt gctctggcct agggccactg taaaaaaatt actgaaacaa 40020tgatagagac ttgaaccaag aaagcgagga agtctctgtg ctgtagttat cggctctcag 40080gaaagaaaaa ccctcctggc ttggcagctg gcccaggagg ggcgtgggca ggaggaggtc 40140cccaggctgc tggatagttc ttcctgctgt tggagcctca tccacagaca caggcctgta 40200gttagccagg cagggaggag gctgagcagg aaacagatgt gcctggctgc aaaggaaacc 40260cacaagcaat caaccccatc ttcattcata aaaaagaacc aaatcaagtg ccacccaata 40320caggaggcaa ataccagggt ggaggataat gtgaacaaat aaaacagctc acctgagagg 40380aaatagaagt aataataata ataaaaatcc aacttgatac tgagagatta gagaggaaat 40440tgcacccata aaattagaat tagctacaat taggaggagg aggaggtagg gagggtaagg 40500aacagggaat aagaagataa cagcacttac gaaaaaggaa gaggtatggt aaataaaatt 40560taactgacaa aatgaaaatt aaatggaact gccaagctgg ctgtccagaa gaggggctgt 40620tccaccatgg agaccaggca gctagagggt cgagccaaag aaacctccca gatctaaaag 40680gaaaaataaa cagacgaatg aataaaaacc taaaagtctt gcaagatata ttcaggaggg 40740tcaaactaat agagactttt acaaatagag aacaaaaata ttagaaagaa atactaggag 40800aaatgattga agcctctttt ctggagctga agttccttat acagtgatcc actgagggct 40860gtgtgtccac ccacaggtcc cctgataaaa cttatagacc ccaaaataaa agaaaaactc 40920taaaagctcc cacaacacag aaggggacaa catgctgtgt aggaaccagt ggctgccatc 40980agaagctaag aagacgcaca aaggttgtga aaaaggtccc gcagatcttg gccttaggtc 41040acgcttcgag tagtgggagt tttggtgaca gatagcgttt cccttgctac aggtttattt 41100attcaccttg tttcaaagag aataaaatat gcataattat aataccatgt gctgacgtgg 41160agggacatcc atcacatgaa aaacaagttg caaaacaaat ggataatagg atcctactga 41220gcttaaatac acatacacag gcacaactag acaaataggc agatagatag ataataggta 41280ggtaggtagg tagagagaga ggaatttaaa aatatctaga atacgtagca gacagctgag 41340attggggagt agaggaggtg aagatgtttg cttttaatct tcaccacttg atactctcat 41400tttttaacag agtataaatt tcttttgaaa ttaaaaaaat tatcgtactt ttagtggaat 41460aaaagcagca tcaggcacat agtaggtaat taatcaatat ttgttaaatg aatgcgtgaa 41520tgcaaaatat atgcctttct accatcagaa gtatagctct attcaaactt tcttcagtat 41580ctcctgtagc actgacaaat taagttttct gtctcttctt aagtcatatt tggtaatata 41640ttttcctaga aattcattca tttcagctag atatcaaaat ggattatctc atggctgtgg 41700actgcaacct cctttccata ttgcttgttt tacataagaa acacatacat attttctttt 41760tgaaaccctg ttataaaagt actcgacaaa ttgtattagt cagttttcac actgctgata 41820aagacatact ggagactggg caatttacgg aagaaagaga tttaatggac ttacagttcc 41880acacggctgg ggaggcctca caatcatggc ggaagataaa gaggagcaag tcacacctcg 41940gatggcagca ggcagagaga tcgatctggt gcaggagaac tcctctttat aaaaccatca 42000gatcttgtga gacttactca ctatcacgag aacagcatgg gaaagacctg cccccatgat 42060tcaattacct cccactgggt ccctcccaca acatgtggga attcaagatg agatttgggt 42120ggggacacag ccaaaccata tcacaaatgg taactcaatg taattttttt aacagcacta 42180tgagccgtgg gaatccaagg catgagacaa gaaggctgga cagcgttcct ggatcacaca 42240gctgagtacc ggtgaagtca acccagtgtg cctcggctaa gggactgctc tcaccactat 42300gcctctcccc agtgtcctga attctaatgc tgaatatttg tatgttctct gcttttctct 42360tagccttcca aagatttgtc atcagtagta tttaatatca aagaataaag gtttgaatta 42420ctatatttgt tatagttttt caggttctaa gtcattaatt tctactatat cttcgttttc 42480ttactcatgc ttttgttggg gctttttaaa ttattttttg cttctgcagt aacatggata 42540tttcatttgc aactttctta taaaaacctt gaaaacttac aaagttttct cctagcacaa 42600tgtgggttac attccatata ttatggcatc ttctaaacaa tctctttatt cagttttaat 42660tttctctatc attttctttg agttaacagc tcatggatta ttcagggagt atttttagtt 42720tccacatggt tttagatttg gtgttaaact ttttattact taaattctat tgtttattgt 42780caaaatatgg cttatgggaa tgctttgtat tgagcttttt tttgacacag aagctataat 42840caatgtttaa ctatacgatg cacatttgaa gacattttct ttaaagaaat actgagtaaa 42900taaaacatat taattattca gttctctgta aagtttatgt acataacata aaaagtagag 42960atattgttaa gtagcctgtt aagactgtgc tttgccagtt tcttattgca tttataacaa 43020cttttatgtc ttttgatgct gttatttggt ttttaaacat ctctggctac tacattctca 43080taataaatta tactttagaa aattaatata aagtagccct cgctcattcc ttattttctc 43140tcaagttcca ctttgtatga tattaatatt gcactttggg gttcatttta ttttttgtct 43200tacatttaag aatttactca tctattttct atgtcatttt gcttcgtaca catgtatgtg 43260tatataaaat ttaatatgac aatatctttt gtaaaggaag tttgacccat ttatatttac 43320tgtatattat catgagtgat cttcttgata agagttctga aacacacaca catattactt 43380ttggcatcat tcactgctat taacacaggt atatgacatt ttaaaaaata

aatcaccctg 43440atctaactta aggcttcaaa tcgttcattt atacatttgc tccaggaata ttttgtaaag 43500tctctattac atcatggaat tgtactagcc actgaaaacc ctttggtgaa aaagatacat 43560atgagttgcc atcttgaagc ttaccttcta aaaatactaa cagcaggaca acaatgcaaa 43620tctgtgtgct ttctatccaa gggcactgtt ctctctgctt tacttacttt attaaatttt 43680cacaactaaa tgactttcta ccaatgagca aattgagaat cacagagttt taaaaacata 43740cctattgtta tctactttgc atgtggtaga tccaagttgc taatgtatat ctgaacacag 43800agccggtcac tatgaacatg ctacccacca acatgtgctc tctctctctt cgggctccaa 43860gctttccata acgcttccag gttgccaaac cgtcaatccc agccactttg aagacccctc 43920ctaatgcttc cctgccattc acaactacac cttgtggtga ctgaacagct gttctgtttc 43980gcttcaggct gttttcctgg gaaccaccag ccattcctcg tgcccactgg gtcttactct 44040cactggcccc atggaccccc tgaggttgtc agtgacttct gttgggttcc aggtacaggc 44100accctttgcc acagagatga cctctggaat gttctcagcc tccttccatg ccctccatgt 44160acctgtggga atgtcttgat gctttccatg ccacagtgac aaggacagca agctcagatc 44220ctcactctac ctatttgagc tgtgcagtca ctagcactgt gagaagacca ccctgaagtg 44280ccggagcagg ggcatcctac aaggccgtat ttgtgcactg cccctctgcc cttgacaggc 44340gaccctccat ctttctggat ttttgccatg cactcccacc ctcaccccac atcctgccca 44400tcaaccttga ggagaaggcc ccacacttgg cgtggacagg acctggcact gtgctgcttt 44460acactctgct ttgccttccc tgccccatgg tgtggcaccc gacaggccat ccctcttctc 44520tttctgttcc accacacctt ccagacacaa aactctatga tcaattacac tttgcctagc 44580tttgaatatg ccaaaaaggg agcttcccaa actgggaaat atttttcttt ctctacaaag 44640cttggccttc gggcctcgtg tgtttctgtg aactcagata gcttcattag catgcagaac 44700ctgcccatcc ttccccgtat gagtaaaccc gctgtctgca tcctggcagg tcaccctcct 44760ccctgtaggg caggaggctg cccaggttgc gtaggagaag cccatatacc gggaaatgca 44820aagcataaaa ttacatcagt gtatctcaaa actgtttgcc ctatttcgta acaactcgag 44880aagtacatgg cacggtgaca tcaccaaaga gaatatttgc ctactttgaa actgaaaaaa 44940aaagattcct gaaggagtaa tgctcgaggt gagttttgaa gaaccatagg aagcacctgg 45000tggaagagga agttaatttt ctttccgggc aaaatgaatg gtgtctgcaa atagccagag 45060gccacaggag catctgtgtt taaacaactg aagaaagccc acagggctgc agaacggaga 45120gagaacaaga ggcataagga gatgccagac agtgggcttt ggcagggcag ggaaggcttg 45180cgtttgtcag gcgtggccat gtctccctgc tctaaaggga aggagaggaa aaatgggagg 45240ggccggcagc ggatactgtt gcggcagctc tggcacagag cacataagat tacaaaatct 45300gatgcctgct agggttggtt tcatgcccct ttcagctgac gcactcatga tccacaggct 45360gaaggaggca agggttgtga gccccaggtg ccagctctgc ccaaggaccg aatcccggct 45420cccttcctgc gttaccccac cttcttccaa gcggccccac cctcaactgt ggaatttaat 45480tctcccagaa ggcctggcac ggtggcttac acctgtaatc ccagcacttg gggaggctga 45540ggcgggcggg tcacgaggtc atgagattgc gaccgtccta gccaacatgg tgaaaccccg 45600tctctactaa aaatccaaaa attagctagg tgtggtggcg cacgcctgta atcccagcta 45660ctcaggaggc aggagaatca gttgaacccg ggagttggag gttacagtga gctgagatcg 45720tgccactgca ctccagcctg ggtgacagag tgagactcca tctcaaaaaa aaaaaaaaaa 45780attctcccag acatgctcag agccaaagca agcaaaatga gggtcctcca ctgagtgatt 45840ctcctgcacc ctccttagct gtccaccaac actgcctcca gttgtcccaa gcctgaaatg 45900cacttgagaa cacgtcctca aatccagtgg aaaagtctac attattttgg gagaacagag 45960catcagacag agctcccaac cccaccgctt cctgtccttt gccttgagga cctccctcag 46020ggtagggggg cctgtgggcc aggagtgggc agcccagccc cttcgatttc acaactgcct 46080ggtttcctct ctggtggaaa tgcacaggtg gtgacaaaac tggatgaatt tcatcttctt 46140tactcttgtt ttagagctgt gagttcgagt cagttacggt gtgtgactta ctaacccatg 46200tttgcatctg tgtgcttctg atcttcacac acgctgagca cattaggggc gccttcctgt 46260ggaccgggcc ccacactggc aatggggcag gcgcacagtt cctccaaaga acctcacagc 46320tgtgccttgt cctctgagaa aaggtgtcag ccagttccac tggacagccg gcactgtcag 46380aaatcctacc ttagcagctg gaccaaggtc tcaccggaga agatgtgtca attcaatttc 46440aaggtccttt tatacaattt aatcaaaggt catcattaga aaaaaaaatc atgattaaga 46500aacgaataaa attcaagtca tactgttacc tctgttttaa acaaaacaat gtttctttac 46560atataaattt ttatttcaaa acatttgatc ccaggaaagt ctttcacaat aagtgagttt 46620ttagcagacc aggagagtca tcagtggata agagttctgg ggtgaaggtt ttcacaaagt 46680gccctagatt gttgatgata ttttaatcat ctatccttgg aatacaatgg acataaaatc 46740aagaagtgta ctgaaccttg aatgaaacag cagaatgaac tctgagtccc agaaaacacc 46800taagaactaa gaatgcgttt ttaatgctca tgaaaaacaa atggcaatat agaatgtggg 46860actaaagaat ggttacttga agccagaagt gggtgttctg caggtgaaac ccaagcgcgg 46920cccctcccca aggctccttt ctgtgttgtg agtgccccac tccccaggga cagcactttg 46980ttttctttca gcttttctga catcatatga tgcaacctga tgcaaagcaa agcgataggc 47040atcttgtcac aggagaaatt cacagagagg aggggggcac gctgcagctg gtgcggaaat 47100tctcaagaga ggcctgggag tggagctgag ccgttgcaga ggaaggtgga gaacctcttg 47160agaagttcat ggacacatag cgtggttcag aagaaaagtc aggttccagt gattgaagaa 47220aaaagcgaga cattattgca ggcaaggatc tccatgttgg gatacaaagg caatgctgat 47280ttcaggatat ctgtgtacgt ctgtgtgtca tgggaaggga ggctgcagtt ggacacgaat 47340agaacatctg ctcaggacga ggacacgtgg gatcacatcc tcagagcccc gtcgtcttca 47400gagcccttct ctaggctgga ggcagtgagg acaggatggg agtgtctcct cccttccctg 47460tttcccaggg agcatggcca gcttggtgac tgtcacagca ggtgagcagc aaactcccag 47520gccagcaggg aggggcgact gtgagcagaa tgacagccac atggtaggtg tgtactttag 47580agcaggggcc tctcctcgag gttaccccag ctcatgcccc agcagatagc ttggtgggag 47640tgctgtgcct gaccctccca taacctacgg agcccaggtg gggagagtca ctctccagat 47700cttacataaa agatgtagca cctcacacac tgctgttaca gagcagataa taaatattca 47760tgatatgcaa ttgaatagtt atttaaaatg tttatctatg gatgaatgaa tgaactgaac 47820aaagagcaaa atatacagac aagtaaggtg tcacaaagct ggctctgagt aaccagcctg 47880ttatcaaatt catttgtaca gtaataaaag aaaacatatc ccaccagcca tgtgccaggc 47940actgacatgg gagcttcaca catatgaagg cgcagagcaa tcggcacaat cctctgcttc 48000atggaagagg aaacaaaagc cccaagaggc tgggccggga gcctgaggcc cagcggggcc 48060agcttcgggc cacctcactg tgtttcaagg cccgccgtcc atcactgcgg ctgtcacaat 48120ccctgtcttt tcttggttgt catatttgct tctcacctca tcatgtctat tttccatgtg 48180gttcaagctt ttaggttaca tggctaatag gttaacccaa ataaaccaca ttatggcttg 48240tttattgctc tctgtacagc actactaaga cgggtgttaa acccaacttc ctcctcgtga 48300aagaacacct aagcctggaa acttcccact tcgctgttca ttataaggtt cgaaaaacac 48360aaactccatg acagtgcttc agaggtgctt tccagcagct ctaggcacaa ggagtactat 48420catttgaggt tttcaggatt ttatgttaga tgaagcagag ttagtaaaat cattttaaat 48480tttcttctaa agaactatca agattgtaag gacattcaaa aacaaatttt atgtacatag 48540tactaataac atccacgtat ttccaaacat ctaaatactt gaaattgtat gtaatcagca 48600agtatcatag tataccttta tcatgactga taaaaccttt ggaagctgag taagtaattt 48660tcaaaaatta ttagttcctg aaagaccctg aaatctgttt cataaattgg aaatgaaatc 48720tagctattaa ttcaagatcc tctagataaa tcataccctg ggcaccttga aagaatcaaa 48780gattttcagt acttttttcc acatactcaa ggtataatat tataagacaa gaaaggagat 48840agactgaggc ttccatttat ctactactca ttaatcattt attgagcatc tacactgggt 48900cagatattat gttaggtatt gtggatacaa agatgaatga agcaaacttc ctgtccacaa 48960ctcattgtaa ctagagagaa taattttagc aggggagaag tagaattgta agttgggaag 49020gcagatttga acaacagtgt ggtaaatctc aaatattaga ctaaaggttt tatcctgtaa 49080ttattggaga atagggaatt atttggaaaa taaaattaac ataaaagaaa taattaaaaa 49140catactacca gcgccggaag tagctttaga gcaggggtcc gcgagctcca gggcatggac 49200tggtaccagg tccatggcct gttaggaact ggctgcaccg cagaagatga gccacaagcc 49260acggggagca ttaccaccta agctccgcct cctgtcagat cagcacttgc attagattca 49320ggaacattgg agcacaaaca ctattgtgac ctgtgcatgc gagggatcta ggttgtgcac 49380tccttatgag aatctaatgc ctgatgatct gtcactgtct cccatcatcc ccagatggga 49440ctgtctagtt gcaggaaaac aagctcaggg ctcccactga ttctacatta cggtgacttg 49500tataattatg tcattatata ttacgatata ataataataa aaataaagca cgcacttgaa 49560tcatcccaaa accatctccc cacccccagt ggtctgtgga acagttgtct tccatgaaac 49620cagtccctgg tgccaaaaag gttagggaca gaatatccag cctctactct catcccctct 49680ggactggagc cactttatat ctagaaaggc gatttatttg ttttgttctc tgcagtgcct 49740ggtagaaagt aatccactca atatatgttt aataaataaa tgaaagaaac aggaaagtat 49800aaacccaagt aactgattta atgacttgcc tgaggtcacc ctgaagtggc caaaccccag 49860gttccctgtt cagctatgac cagagcccat tcttcattca ttgttaaaca taaactagat 49920gttttatcca cacagagata gctatctaga gatatgaact tccagaaagt tgaccgtatt 49980ttttgtttac atgtggatat ctgatatctt gaaaatatac acatttagtc attaagttta 50040aaattaaaat ataggcctaa aattttttgg agccatactt ccaataataa tattatatgg 50100atgcacaagc tatattacat attaggaaaa acaataaagc cccaaaccta cagatttctc 50160tctctcacac acacacacac acacacacac acacacacac acactgctca ccaagattgt 50220tgattctcca gttttccaaa cactttgttt ctctactgta gctctaggtg aaacaagact 50280gatcctgagt ttatagctgc tgaagctggg tgatgactcc atggcttctc attagaccat 50340ggcctcttca tctgtatatt tttcaattgc ccattaaaaa atgtttttaa attgagagcc 50400aaaaaagagt atccattaac aaataaatgt atcattcagt cggcttattt agcagcagtc 50460agaagaaaac tccttctgaa ctgagcaggt caggcatcta tatagaattg tttcttggca 50520gatggctgag ctgtccagga gtaccaaatg taggcacctg cccaaggtaa cttaggaggt 50580tttcccctta gaagggagag agagagagga ggatggagaa cgtctctgca atcccttata 50640tcttattgca taactttctg ctgaatggag agctgcctgc ttgtttcagg gagaatgtca 50700tttttttata cccaaaactt aaaaaacaat attgttatgc agaaaagatt taaaaaattt 50760ctagagttgt aagtgaaaac taaattacta ggaatcattc atcaaatttt accaactcta 50820gattctgatt ttatttttgt atgtgtgcca aaatagatgt ttacccatgg gtacagatca 50880caaccaattt gcaagagcaa gtgggaagaa agctgactac tccttcacct ctgctgcact 50940tcctaagttt gaccattgat atctgaagat agaagtcaca tgtgcatgtg tgaatataaa 51000atataccttc ctcaattaaa tatacaagac aaagccactt taggaagcat attctcagat 51060tgttggctgc agtctttgac caacccaaat aaagattaga tagttgtaac tgtaagagct 51120gaagaaactg aaaactgagc atatttcctg aaattgtgag catagttaag tgtcttcact 51180ttttcagaaa aactgaaatg ggatgaggag acaaaacccc tcataaccta aagctctgtt 51240attttttttt tttctttttt ggagatgaag tctcattctg tcgcccaggc tggagtgcag 51300tggcgcaatc ttggctctct gcaacttctg cctcccgggt tcaagcgatt ctcctgcctc 51360agcctcccaa gtagctggga ttacaggcga gcgccaccac accagctaat ttttgtattt 51420tcagtagaga ctgggtttca ccacgttgtc caggatggtc ttgatctcct gacatcgtga 51480tctgcctgcc tcggcctccc gaagtgctgg gcttacaggc atgagccact gcaccgggcc 51540ctgaactata tacatttcta tctgcacatc taatgtctag tatccgctga ccacagaata 51600aactcaataa atgtttgctt ttgaacatat aaatcattgt tgttataact ctaattatat 51660gagaataaat ggaagatact ggcataatct atatacatat ttacatatat aggtatatgt 51720catctataca ttgttcatac agatttgagc agaaaacctt aatgagcgaa ccctgacaca 51780tggttgcttc agctttaagt gtgtccaaat gtctaagaaa atatggaata gaatttgtaa 51840tagggtttta agatcaatgc ataaaatatg tcactatgtt tatgaaagca tagaccgcct 51900gagctgtaac aggtacagag ttctggaaat atgaattctt cctttcacac actattaaga 51960tgtcctgcag gagtcgaatc gttttaatgt ttctgttctg gatgaaataa gccacattta 52020cgcagctaca atctctagct aacacagatg agtaataagt tttaggccga aatgattgtg 52080atgtgatgct ttcaagtgag gaagtgccgt ccagagtcac tggctctcag aattggaggg 52140aaattcatgc agtggggaag ctcacagagg atctcgctaa agactgagtt aaatggcctg 52200gaactcaact tacaagcagg ttaaaaaata acaaccttcc ttccttgtct agctccttta 52260agtgaagtat tttctatctt ggaggcctct tttgaaatgc aatactcctg agagtggtca 52320caccttaagt tatcagctaa cactttccga gggattagca gacagccggc agagaaaaag 52380aaatgggatt taggcaaaat gcctgagggc tggaggggag acactgcctg gagaaaggtt 52440aactagtctg ttgatttgct gatagacaaa tttcacgtac tccagagcat ttggtctaca 52500gtggagactc ccaaattctg gattctataa caccaccaaa aagcctacaa tttcccagat 52560tatcttgcaa gcaacttaag tctgcatgga atacaaacaa aataaaccca ctattggcct 52620ttgtataatt gaaaattatt aactttactt agaacatatt caaattattt ctgaggattg 52680tttatataca tgagatcaga ctttttaaat tataaatgca ttttaagaag gtaaaggaca 52740cagtaaaaat atagcaagtc ttaataagcc tacacagtga aaactcatca gattcttcta 52800gattgcaact aagatacact acaaaaaacc ccagatgggc caggcacggt ggctcacgcc 52860tgtaatctca atactttggg aggccgagaa gggcagatca caaggtcggg agttcgagac 52920cagcctggcc aacatggtga aaccctgtct ctactaaaag aaacatttct gttccgtatg 52980aaataaacca cactcacaca gctacaatct ctagctaaca catacaaaaa ttagtcgggc 53040atggtggcgg gcacctgtag tcccagctac tcaggaggct gaggcaggag aatctcttga 53100acccgggaag cggaggttgc agtgagctga gatggcgcca ctgcactcca gcctgggcga 53160tggtgtgaag ctccttctca aaaaaaaaaa aaaaaaaaaa aacccagatg tgccctgcct 53220taggattttt tgacttaaca atggcacaaa agcaacacac atccagtgga aactgtattt 53280ccagagctga aataaccatt ccgtgtttca ttttcaagag gctgttcagt caattatatg 53340agatattcaa ctcattatta taaaacaggc tttgtgtgag gtggttttgc ccaactgtag 53400gctaatgtta agtattccga acacgtttac ggtaggctag gctaagctat gacgtttggt 53460aggtgtattc aatgcatttt cgacttacat ttttagttta caatgggttt ataggaatgt 53520gtattagtcc attctcatac tgctataaag aaatacctga gactggataa tttataaaca 53580aaagaggttt aattgactca cagttccaca ggctctccag gaagcacggc tcaggaggcc 53640tcaggaaact ttcaatcatg tgcgggcgaa ggggaagcag gcacatggct ggagcaggag 53700gaagagagtg aagcgggagg tgccacacac ttttcaacaa ccagaactca ctgtcacaag 53760aacagcaagg ggaagatcca cccccatgat ccaatagcct cccaccaggc ccctcttcca 53820acagtgggga ttgcaataag attttggcag agagacagac ccaaaccata ccagatgtaa 53880ctgtatcata agttgaggga cattggtata tagcttatat aatagaaaaa gagaatttct 53940cttcagtttt aggaatcttt tttttcccca ggagcctatt tttaattgtt cttactactc 54000tgggtatagt atgttacagt cttagagtat ttatgcttta tcttcaaatg tcagcttaca 54060ctgatcaatt tagggcagaa gcctgttata gtcctttctt ggaaccacac cacatagaag 54120aaataatttt tttttaactt ttttttgttt tatgcttttc tgatactttt tcctacggac 54180ttcctggagg caacaaagct aaacaagctc ttcaaagttt aatcgacctc ttcggatcta 54240tgactgtatg ggtaggccct aatggactta aatattatca aaagttgctg agcacaggct 54300ttgtaagtgc acatttcgtt aatattgcct ccacttctcc atttatgatc atggggaaca 54360cacgcagcac agacagaagg tatctcccca ctccattttt ttcattgatt tgtatcttct 54420tttgccatga aacttttcac tatcaccaat aacaaagagc cagacagaga tgaatttaca 54480ttcattacct taccttattt ttaaccttag gcaaccataa tcgtgagcaa gtgaagggtc 54540aaagctatta gtattcctaa atgaatagta gatttatttt gaaagtgatc attaagagga 54600aatgtgctta ttccttagtg ctttaatttg gcaaacacat ttgagtttct cttgtgcccc 54660aggtaccgtg ctaggctctg ggtgtcaaag gataaggaca aacacagctg ttgcctctca 54720agatctagca taaggcaaca attagtaaac tgggtctaat ttgtgaaata gcagtatgtg 54780aattctgttg aaaaatactg aactcatgcc caaaagactc ggtttatcat cccagcgttg 54840acatttacta gttatgtgac cttgaacaag tcactgtgtc tccctcacct ctaggttttt 54900ctcccaaaaa gtgtgacatt tgaccacaac tagatgattc ttttctgttc caaagctgta 54960tgattccctg gtcatagtca agcccatcga tggggaaaac tagaatagaa cttattggat 55020gggtaccatg catgccatca tttaacgtcg ccttgtcctc tgggggccgt tatcccacag 55080gactccatgg cttcctgcct ctctaccatc tcctctctct gtggaagcaa gggtcggctc 55140acagtttgga atctcaattg ttgagaaagt gtaattgttt acaaggacag accaatgagt 55200aaaaccagcc atattttcac acacacaaaa aggggcgata gatctcaact tctcattatg 55260gataaaaatt tcaaaatatc aagtcaggtg aaggacatgt gcagcgagga ctggtgtgac 55320ctcaggactc agcatttatt ttacctcatt agtgtaagaa tgtcacaaga ttgacaggaa 55380cagcaattca atcaatcggc ttcaatcaag gctaccaaaa atgagagcca atctcttgcc 55440attagatttt gggcttcaaa caattttagg aagaagttct attcgctagc tgtataaaca 55500ctagaaattt attgcctgaa atctttgtat gaaagattat tccctgaagt ctttgtctga 55560aagttttgcg tgtaagatta gcaaatcttt ttaaaaagca ataaatatca aacaataaga 55620aaaaggaagt tgagaaactc aaagaccaca gtttaatctg gaatggatcc actggaaaag 55680tatattgtta acatgagttc atctaaacgt acacgctaac ttgtagcaac tgagtttcaa 55740agcccctccc tcattctgcc cccactggca aacaatttct aggtctgcta ggagaaaaag 55800atcttcaatt gcctcagtga gaggatgggg gcagaaagga gcctcaaatc ttccatgtcc 55860acataaaccc ttagtcatct gtcacatgtg aaatccctgc tgtcagccct gacccacatg 55920gcaggagcca ggctcattct gaagcaacac ttgttgctgt tgcaaggagt gacctgttca 55980tataaaagcc tacttcacag tgccaggcta acttttgttc agggacaaaa tcctctgttg 56040ccagaaacaa caacagcatt tgctcctcag gtcaacgtaa tacctcacta atgagattac 56100cttcttcatt ctaacagatt tttctgctat gtggagacca agaatatgag aatgcctact 56160taatttaatg tcctctgaat attatactga tttgaaaaaa aaaatactgt tgtttcaatg 56220ttgctgttga catttgaggc agagggacag tttacaatgg gacacgcagg actcacatcc 56280agtgagtagg aaggactttt tcagcctggg ggaaaataag acaaagtgat ggttaaaggt 56340gatggctcca gagtcacagg tgtgggtttg aaccctgggt ttctcatcta ctagctgtct 56400ggtcttggat aagtttctta atctttaaat cttagtagtg ctggtaatat gaaggtttgg 56460gtgagattta agtaagattc tgcactaaaa gcaattttca ccataccttg cacgtagcga 56520aggcctacat ttccatatat atattattcc tatttgtatt acattaccat ggctgtcaca 56580acaaagtacc ccagacttgg tggcttaaac aatagaaatt gattatctca cggttctgtg 56640ggccagaagt ccaagatcca ggtggtggca gggctggctt cttctgacat ctgtgaggga 56700ggctctgctc caggcctctc cctggctgta gacgcctatc ttctccctga gtctctccac 56760atcgtcttta ctctatgctt gtgtctatgt gcaactttcc cctttcgcta aggacagcaa 56820ccatagtgac cttgattacc tctctaaaga ccctgtcccc caaatataat catattatgt 56880gatgctggga gtttcaaatt tcatcacata aatttggagg agacacaatt caatccatac 56940tgctgttgat ataggtaata ataacaacta ttattagtat catgtttaga gcagaggtca 57000tccactccag aaaactgcat gtctttgaaa tgggaaattc tttcctagtg cctcgaacgt 57060aataaatgac ttgaagtggg taagaagagg ctacaagaat gaatgagtga gtgagtgaac 57120gtaataaatg acttgaagtg ggtaagaggc tacaagaatg aatgagtgag tgagtgagtg 57180aatgtaataa atgacttgaa gtgggtaaga ggctacaaga atgaatgagt gagtgagtga 57240gtgaatgtaa taaatgactt gaagtgggta agaggctaca agaatgaatg agtgagtgag 57300tgagtgaatg taataaatga cttgaagtgg gtaagaggct acaagaatga atgagtgagt 57360gagtgagtga atgtaataaa tgacttgaag tgggtaagag gctacaagag tgaatgagtg 57420aatgagtgag tgaatggtgg gcaggatatg aggagcctta aggatttacc tccagcaggg 57480atggggcaag tgaccaatgg agctccaagc atctgcggga ggtaaacagc agatgtataa 57540aaggagcctt ctcgagagcc tgcaggtcta agaccacagc gataggagga cagggcaaga 57600acctctgttc cagaaggatt gggaccagga agaaagctgc agagaggcag gctcgtgctc 57660acctgcagtc atgcccatct tgcccacctg ctgtctgcga ctaggccaac tcctaaacct 57720ctctgaagct taagacctgc cacagtgggc tgtgccagag ttggagtgga gactcactga 57780gatcatctag aagaggcacc tgcctcaaag ccttcaggta atacccacac ataaacctta 57840gggtttttcc tacctgcaat tctgtgttct ggccccttca cgatgaccca gccagcctag 57900gcatcaagcc acggaaagtc ctagaggaag tgggacctgg ctgaagtggg tataagcatg 57960tagagaccaa agctggcaga agatgacccc ggctatccat ccccatattt tgggaacttc 58020ctggaggaag ccatcctacg aggtgcccca gaggaaagga acctattttt aatgaggtta 58080cattgtaact aaattgatag cagggaggga gaaacagaag cttctgaggg agtataggtg 58140tggtggatat ttgataatac tctgaaatat ttttggtctt attttatttg cttttactac 58200aagaaaagaa aatctgcttt atttagaaag ccatttagaa gtccttactg gctaataaat 58260acataataag taaatattta ttatacttat tataatatat ataatactat ataatatata 58320aatactatat aatatagtaa tatatattaa gtaatattgt gacttcttag gaaagtcaca 58380ttatacattt attagccaac ttaaactcaa aaatgagaaa taagaatgtc cttttataaa 58440ataaacaaga cacacaaaaa aatctaactc caaatatcta attcaagctg

ctgattgaaa 58500gttggattgt aagtggcccg tgggcaactt ctacttccta ctacaaaata tgttgttttc 58560cttgcaaaag agtacttgga aattcttcca ggcaacagca aattcagtaa gcagatgagg 58620gactctgact gattaatata aatgagagtc tagaacagca gaactctgga aaatgagcaa 58680gtaaagaagc cctgaaaaag aaaaagcaat aaagcttgcc tgttgattca ggaaaacagc 58740ctccattgtt actgaaactt gattcacagt tgatggtgag ttatggaaag ggcaaaagga 58800caaaatcctt ttataaatat agttctgtag ggcatgggaa gcaatcaaat ggtgctgtga 58860gactgaacac aaatcatgct tttttcaagg ataattattt tgaatcaaca acctaagtat 58920ttccagtgca cttctgcaag acaaatattt tcttgggatg aaaaaataaa tatgttttgc 58980aaagaaatcg agaccatatc caaaaaggct gaaaagggtg tgtgtataca catatatacg 59040cctatataaa cacatcatat atggtctatg tacatacacc acgtgacacc atgtatcaca 59100tacatgcaac atataccaca caagctagta ataattattt gtaccaaatc tatttcttaa 59160gactgtaata ctgtgttcac acagtcacca tttagagata tattatcaca gtgtcaatca 59220ccaggactac agactattct tatagcttgc tgaagtttag ttttgtactt agaaatcaga 59280gctgatctct catacacagc aggaattaaa tatttaacag ttctccatag aacttcataa 59340aaaaagagta aaggagacag aaattactgc ttttgtagaa gaagaaaatt agtgctttgt 59400gtaatattta cagggactgc tgatggagtc tcaaagcaag aattgttttt tagggtaaag 59460aagtgaattg gcaatacctg cgttactgga cagtccttaa ctccttggtg gtattctgtt 59520taggaccttt ggtgaagggt cagtcatggg attttgaagg gtgcattgat ctcatcagga 59580aacattctgc tgccattgta acccttgccc actgtgattt tctctaaaag agtggagact 59640ttttagaaca cggaatgact ccaacaaggg tcagactcta acaaccaaac aacaacaatc 59700aacaactact tcacagttct cagagatcag ccctgccacg ggaaacgcac agtaaagcaa 59760gagcagggtt gacattctct gtgaaatggc atcaggcatg actctggagc aatcttacag 59820atggatagcc ttgatctcct tccaccagtt ggctaaagga ttgaattttt tactatctgt 59880aggagatagt ctatgatctt gttccaaata tctgaataaa ctttaagaac cacagtgcaa 59940tcacttggac acgatcccag atccatccgt ccattcatcc atccacccat ccatccatca 60000ttcacgattg actcaatatc ctgctgggag ctgggaaaaa agagacatga agtatccctg 60060cctctgagca gctttcagtg cagatggtat gccagggaca atatacaaga cagaatagag 60120ttcattcaag tattctatgt tttgttattt agttttcaaa tatgaaccct ggatggaacc 60180aggctttgtt cccccaagtt atcagctaaa gagaaagagc tcagccaagt gacaaggtgt 60240tgccgcagtg ataactcaat tttgtggttt tcagaaatgc agaagaaaga aggttggaaa 60300gaatgggctg gcactccccg aagagtgggg ctcaaagttc tggtctcagc agatctttga 60360gggagacgta gggtctaggc cggcaaaacc agagagaagg ataggctttt agatgctcat 60420cccacccaaa accatgaaat aatctcccct gtctcctgat tagtatttgt cagcctcatt 60480tacccttaag atttgtgcaa atgaaaaacg ttaaatgcag ttcctggatc agtaattaaa 60540cataattatt tcagtggaag agatttttgt tttcataatc tcctctttgt ctgcatagag 60600ccagctcttg gttacatctg ccactgatag cctttgctct gtttacttta aagaataagc 60660cactgtttga tttggtttct tgttttcaat atgtaaaccc tggtctcttg attccccatt 60720ccaggaagga aaaaataaaa gaacaaggct ctttaaatat cagagccatg atgacttaac 60780agatacacgc aggctcaata ttttatgtaa cagccactta ggaaaatgcg taagaatttc 60840ccagctggca gccctgattt ggcaggtgta cctcaattga accaatcgct tttcatctgg 60900ctgtcaattt gtttggtttt tctggctaca ttgcaccaga gtctgtgtgt attccaaaag 60960gtcgttcacc tattccacgg ttcaaaggga tcattctgtt cacttaaagg gtcactgtaa 61020tcatatattg aaacatagct aagtacgatg agctagaatt ttaggagggg taaaactaat 61080aggaaaatcc aggagtataa accacaaaac acacataaaa aaagagataa aaacagaaaa 61140cataattcct caattaaaaa aaaaaaggaa ccaaaaagaa aaaaaatcta taacaaacca 61200cactgtagga gtctcactat acactaaaat taacaatcac agctggggta aatactttat 61260ttattttatt catattctgc actggcagca tattctagtt gcctgtttga tttcattaat 61320ccaaagcaaa agagaagtag agatttatgt aaatttcatg ttatgctcag attgtaaggg 61380agccactaat tgaacttcag gtcttcctta ttggaaggaa gacctgaaga tgaatggctt 61440catgaaataa tcgtaaatga ataattcccc cacatccgta agtcagccta cttctgtaaa 61500cagaaaaaca aggtagtagt cccatagtct attttttaat ccagaaaaag tcattcttgc 61560agcaagaata agggaaacta tgtcccaaaa ataccaggtt ttccagatat agggatcatg 61620tttgaccaaa acaacccttg gcctaaaaat actgctatat tcaaataaga ggagttgctg 61680ttatttaatt ttactatact atttatactt acatgggatt tttataatga tactactgtg 61740gttttcacag atgtttggct tgtaaaaatg ctaaagatta caatctttag gtcaccaact 61800acctgtattt atggaggcta caggacagag cacagaacag ccaggaagcc aaaacgcgct 61860cgaattacct ccagcactta ctgccgcggg actcaaaccc gagtcctttc tgggactgct 61920tttccttgaa cataaaaatg ggggtgatat caccttccac agggatctcc taactgtaca 61980gagggcttag cacactgtct ggcactcaga ggccttgctg gatcgtgatc cgccccctcc 62040agtcagcgac tgagacccct cactggttca agggcaaaca cagtgctgag agctgtgtgc 62100ctggatcccg ccagcaggtg tgctggggta gggaatggaa gtcaggcatc ttgatctcca 62160tatgtatcca ccgatggaca ccctgcctgc ctttcactgg gctcacccta aaatggtgaa 62220caaagaaaac agctctcacc tctggagcca acacggaggg gtgggtatga gtgcagatgt 62280ggtgggggtg ctggtggagg cttgctgccc atctggcttt tcctgttatt gacatgctca 62340gatgaaagtg ggccctgttc acaaacatgg catccattcc tgggactcat cccgagcaga 62400acctcaaata aaaaccagaa caaactacac taatttgctg aaccccaaat ggagccaaat 62460tcaaagctct tacgaaacta caaacagaac cacagtttca aaaacaccag gaaaatagtc 62520tcaacaagac attacctaca tgaaggatgt ctgaaatcta ttttagtgta aaaatgctat 62580aagtttactc tcctactttc taaaattact gaattagtta ttaaaataac aacctaagta 62640atctgactgt aaattgagcc atattttatt taccctaaga tctctcaatc aaatggagat 62700ataacaaggg ttatcaattt ctactgcatc tattcctgta acatattaaa tctccatctc 62760cttgagagaa gtacattgat ttttccacag gagaattttt ttctagctcc aagaacagct 62820gagggctgca aaactgagca gatggccaca tggaagaatc tgcttggttg ataagatagt 62880ttaaaagaaa aatcacctga ctgcacatcc caaatacctg tcaaagtagg tcatgaacac 62940tgcttgattg gaacaaacca aaatatttaa tggatcgaat cttccagagt tcatgataac 63000tgccccacca aaggtctggg cttaagcact gatgtttcct ttaattataa agcccagatt 63060gtaaggcaaa cacagccctg ccagtgtgtt tgtaggtcca gtcagtgact gtgctgcgtc 63120cacaatggtc tttatcattg tcacttgttt gacctgacta taactgagta aagcatcatc 63180attacaaaat gcagcatgcg ggatagtaat cacctaaaga tatggttcaa gcacttcacc 63240aacctctgaa cctgaatatg cctaatgaat tttgtaaacc ttacaaaaag tgaagccagg 63300tgattatcag aaaaaagaca tgtgtcatac taaagaaaga gcatgttctg gacctgagaa 63360aacagcagtg cagaagggaa tgtcttttct ccacagtgat atgtggccac agccttgaac 63420agcaaatttg cagattaatg aagatagtaa aatagatcac atcctcctgc ctccaggtat 63480aatattttat tcatataaga gctatgtgag ccttgattta tatgaacttt cattagtagg 63540caaaattcaa tcataaggtt tcctcttttc acctctaggc gtccttaaat tcaacacaca 63600gtcaaatggt gattggcttc ccctctccct aggtaatacc ccacccccca gcctcccaaa 63660aaagacagaa aaagaggaaa atgaaaaaca agcacgttag aaaggtggcc agacaaaacg 63720gtttgcatca acaacataac ttctgatttg ttctcccgct gggacagtct aatgcagcct 63780cattcagctg tgcattttca atattattca acagagccca ctcaggtcaa agtagagtct 63840tttccttcac aagtacagag atacaacact aggtttacgg gagggctatt ttcaatcttc 63900ttgagcggta atgtgtttcc attatggttc catctatttg tgatctataa tgctttccaa 63960atagccccaa atttcaaaga agctctagtt ggttccaaat ggaaatgaga ttacatattt 64020agtattattt tattctcaaa tgttagattt aattaggttg ggagcattca ttcatctgcc 64080cattgtgttt gttgacttca ttaagggaca atcacagaat tgcagggaag tccacgtagg 64140gccccccaaa ctgcgattgc ttttagcttt tataaaccat taaaatgtaa gtcaagcaca 64200taaatatatc tgctatgaaa agaagtggta ttgctaagtt ccctgataga tgatgacagg 64260acttctcaga attcgaaggc cagtgtttta atcttcaggt tctctcaggt cacgtgcttg 64320ccaatgacat tggaccagga atctccagag gtgagaaagc cccggccaac cccaaatgca 64380gctcttgctt ggtgaaagca gagatggggt gaggacaggg acacaggcag aaccctgccg 64440cgctccagct gagctgctca cttgccactc ccagagaaaa caggaggatc gacctttctc 64500tatgcaacgt ctaaaattaa tttggtgctt aaaatcagag gtgggtcaag cagttgatta 64560cctgaggttg cctttggact aacaaaggcg tctcttcagc atggtgaatt gctctgatgg 64620ccctgggccc ggagcagtga tttgagaaaa tcacccatgg caaccattag gcaatgagtc 64680tccattgact gccaaaatct cactgaatat tgaaggaaaa gagaatttat atgtaatcca 64740attcagagca acaacaacaa caacatcaac aattcaatgt tccccagttc ttcatgggaa 64800aacttcaatc caggtccaaa gagagctgca agaacagcgc agttcacaca gaaagtctgc 64860attcacaggc tgggctgggg tcgcaactct gcgggcctcc ccaccctgcc acgctttgta 64920ctgctgtgtg attttagcgg aggcatttag ctcacacagc cttagtttcc tcatctgtaa 64980aattgaatag ctaccttcta ggctttggga gaatgcaatg gaaaaagaat cttgcctagg 65040gcatcatcag ctcagtaaat aatagttatt atcatgatga ttatcctcca ggtagctgtg 65100atgtgtagaa gcccagaacc aagtagcaca ggagacagag gtagttaatt caaccctcct 65160ccaatacaac tgagtgccct aattatccga atagaagctc cactgcagga aaactctgtt 65220ttggagctca aggaaagacc tacaagggag aaccacagag ctgtaattat cagctgaaag 65280aggaaggaag ttctaatctc acagagccct tggagacttg tgaacacccg aagcttggag 65340aaggcttcaa cagggaacaa acggtgaaag ccacacaaaa atgaacttag cagcaggaag 65400gagtactcca cgtgcccctg cacctctcac caaagggata cagatatgtg atgggtgttt 65460ctgtaatata tgcctcattt tccaatggaa aacctccata tacacatgag tgcatggaga 65520ggtcatagtc actggtcaag gagttagaga tgagtgggga aaagtgatag ggtgagcatc 65580ctcaatctgg ccccacccta tctggcgcca gacacctaat gaaccacctt tactggggga 65640gacagggtca aggatgaagc aatttcctct tcatatctag ctatcattta ttctacatag 65700ttgatgcagg caatatgctg gctgtttgaa gcaggtgata tttctaatcc acacaatggc 65760ctgaaaggta agtattatgg aatcacttat ctggataaat aaaacatgag gttcagagag 65820attacgtaac tggcctagat caataggtgg gtaggcagac aggtaggcag gtagatagat 65880atagagattg aaatatactt taaaaacact ctgtttgccc tacattcctt gctttagata 65940ggattctgaa tgtggggcgg gcaggaaagc tgtcagtcac gaagggagcc tgcccaccac 66000aaggcgagtc atgtgaccca ggccagagaa tcaggttacc ccacagggaa catcagtgat 66060tggcccaggg gtaagcaggt agctcatgta gcaccagagt catatttttg aagtttttat 66120ggaagttgga aagatctctt ttggaaatta ccaactccag agaggatgtt agcctgggag 66180tgccaggaac tttctgtgtc actggggaaa gcgagacttg attctccgga tatcattgac 66240catctgggtc ctgtggtgcc tgacgctatg agttctcaaa gtggggcccc caaagcagca 66300gcagcagcct catggccttg ctggaaatgc gaattctcaa cctcagctcc cagactcact 66360gcattacaaa ctctggaaga tggagctgac tcagtgagat ctctttccaa gctctctaga 66420tgggcctgat gcttattttg aaaagcactg ttctaggtca atccagggaa ctgttaaact 66480tcatgagcca atagataccc ctcttcttgc ctaaactttg attataataa aagaaaaata 66540cagcaagata gttttgaggg ttttttaata aaaatttaca attatttttt aatcgcaagt 66600aaacttaatt attttaccat taaaacctct tcaacacaga aattcctttg aggtttttag 66660ttttgttctg tgtttgtttg tatgtgaggc aagacacccc tggatgcttg caaagaagag 66720gcaatttgaa gtgaaacagg cagatgtaca atctgatccc ataagtgacc cactgcagaa 66780cagacagctg gacatatgga catatgcagc tgcctgtcat ttatacacga gagttaaaca 66840gttggcaaag agagtctggg ccacagagtg gtgagctggc tagaggtgcg gatctagcca 66900ttggataaca ctgtacttaa aacacaaaac tctatccaag aagaggaaat gattgaatac 66960gaagtatttg aaaaaagatt tgaaagactg aaaatgaaac acttccttac attcgctaag 67020tgagctgaga aagaattgcc cagaagggtg atacggaggg ctagagaatg aagacgacag 67080ggagtggaag gagagagccc acctacatgg cacccagctt tgcagaggct cctgaagaca 67140caaggttgaa ggccctggac tcaaaaattt ccttgactct gccaggcaag agggttagct 67200gtttcagcag agggtagagc caagcgaaag ctggagagtg aataagaaat gctaggagca 67260attgcgtcag gtggggcaac caggactgtg tttgccttcg gaccagggct gccgagtaca 67320gatagcaggt ggtttatgtg aggcctggag caggggtcat tgcaggagac ggggttgctg 67380tgtgcctata aatggagtga aaaagtgagt gcaaagaaat ggaaaagtta ggagatgcag 67440cataacctgt gaatcatgat ccctgacaaa gtggggaggc tcatgggtgc aggtgtaggt 67500gtgtgtgtgt gtgtgtgtgt gtgtgagatc acatggctgt ggacagaggt gggctggaac 67560ccctaacttc caggaaactc caggttcttt tcttcttcta cccataggtc tgcattgtgt 67620ttttctaggg tcactcatct attcatccaa caaatattca acaagcacct gttacatacc 67680agattattac atacatgtgg cagtgcacgt aactgtgaag ctgtgtacta cagctgcagg 67740gcgaggactg gggctttagc tcccaccttg tgcaatgtgg gatcttctcc atcgtcatat 67800caagccaccc cacgtgtatt taatgtaagt tggaacactg tgcttgctac aaaagtcagc 67860ttcagaagaa gcccctccgt ggatcaccac ctccctacaa gctgcagtcc taatctccta 67920tgtcaaaatc agggactgct gctgccccgg ggggtttaga gatgaagacc cagactctga 67980ctgaggagtc tcccagtgaa aggaaggagg cagaagccca gtcaccagtg acgccaccca 68040gctgagtgga ccgcgcagag ggaggcggac gcagggcact ccaacatgga cctgagaggc 68100acacactgca atgcaaatcc tccacgatag tccacaggat gtactgggag aaactggaag 68160gccacaggag aaacgtttgc tcacgaaaac acaggcattt catgtgcctg gagcacggga 68220tgaagaattc cttagacttt gagtgccaag ctagtgcttg gactttcttc taaaggtcat 68280gggtgagccc ttggggaatg tggagaccac tccggcctgc gatggagaag gaaattgtgc 68340cagaagctgg gaagtcaaag ttaaccctcc aggctagatg taagtaacgc gtggggctgc 68400acatacggct gtggcagagg aaatgggaca gagggattga ttttagtaca gaaatcctaa 68460ttgggcttaa agtaggtatg ggaaaacccc tgaaagtgtg tgctgatctt ggtatgtgca 68520gatattattt tcctcctggg gtaaacttta attctcaaag gagtctatga cccccaaaaa 68580agtcatctcc ctacttgaaa gatgcttgag tgtctaatgg ccaggagcgg gtgttggtgg 68640gataccaagc ggtgggagga acacagtatc gtcctcaagc ctctgacttc tcctagacag 68700ggtagctaag aggacttttc agatatgttg cttttgaggt gtctgtgagg agagggaggc 68760aggaaacgca ggcacacgca ctcacagtgg acgcgtcttt agaaagctgc acattctcta 68820attgagttaa ttgttcacgc actgaatgga gctgtttctg ctcaagctag ggaaagactt 68880gtcagctgtt tcttcacttc catgaccttg gaaaatccgc tgtctccacc agacactgat 68940ccttggcaca gccactattt gatacactta actctgctca ggattttaga tctcaaccca 69000ggaaatgagc tacagtctca ccccaggcaa gtacagaaca ttttcctaac caggagagac 69060gcctgtgtca cacattccaa aggtagccag cagctaagaa agccgcaaca aaggaaatca 69120aacagctctc tctcccctaa acgctgcttt caggcaagtt ccaaacaaaa atggaggatg 69180cactgcaaat taaaaacaaa agcctgccag tcaaaggcag tgtttttaaa cacagaaaga 69240gcaataccac tgcagggggc agataaaaga gcttttgagc atctcagaag ctactcacac 69300acaaaagcac ctctgtgcct tcaaacagga tctcctagaa gtttcccaag gtttcataac 69360ccaaataccg ctggtagtga tgtggtttgg aaattaacct tgcttttctc cccactgctg 69420ttttacatat taattaaagt gttttcctca gatcaggaac gcctgcaggc tggctaggtt 69480ctgcagaagg tgcctcattt tcctgccgct tcccgccccg gccccacttg tgcatagttc 69540aatgattaaa acttccccag gtcagctgta gacgcctccc ctcccttaac tgccatcgtg 69600atatagaaca cacactttaa tgtggctttt aaaaagtaat cgcttcccca ccccccaaga 69660aagataggtc gtgcagagct aatttcggga agccatttag aagaaattgt tgagaaggca 69720ttgaagtatt tgggtccaac tctgcttacc tcattcatgg acctgtttct tttctttttt 69780ttcttttcca gtgcttgaaa taggtgtgca aacaattcac atattataaa tacgttgact 69840tgggccgggt gtggtggctc acgcctgtaa tcccagcact ttaggaggct gaggcaggag 69900gattacttga ggtcaggagt tccagacaag cctggccaac attgcaaaac cctctctcta 69960ctaaagtaca aaaattagcc gggcaaggtg gtccgtgcct gtaatctcag ctactcagga 70020ggctgaggca ggagaatcgc ttaaacccag gagatggaag ttgcaatgag gcgagatcac 70080aacaacccac tccagcctgg gcgacagagc aagaccctgt ctcaaataaa taactaaaat 70140gaaaataaat aaattgattt gttttcattc atatattttg gggatacaat ggagcttaaa 70200gtttgaaaac caaaacggag ctggccacca aaggtgtgga tttggtcaac agggtgtgga 70260ctccagcagc ccgtgtcact ctcagactcc atgtctcaat ttgaatgttt ccatgtcact 70320taaaaagtag aatattcata gtgatgttga agatacaaaa gatataccag gattaatttt 70380ctagtcaatt ttatgtgtct gtgacccaag acaataaaag ttaagtcatc gttagttcct 70440tagttgctgg acactttagc ccaatatacc accttcaatt ttgaattatt atttggactg 70500tgttcatgag attcttggag tatgttaaat caacacattt ctttgtaatt attgagaacc 70560ttttgttccc tataaaatca agtgtacgat gatgtaaact ataaaacgca aattgtaggg 70620acaattggta atctgcagtg aaaataaagt caaaatagca aagagcagat tattctcaaa 70680tttatgtaac agagttctta catgtggaag tggatacaag tattagcaca ttcagttgat 70740gtactgaaaa taaaatgaaa ctatttttct acttactact tgcttgtgaa atccaaaggg 70800gtgaataaga gccaggattc attgtcatga gtgtaggggt gccctgggaa ggaggcctcc 70860atcccacgtg tcagtggcgt catcagaaat tccatgatcg tcggcttatt ctttgcacac 70920gtgtctacag ggtccctccg cacaccgact tggtgtcctc caggatgcag aaaacccaaa 70980ttaaactagt ttaatgaata aggaaactaa gtggctctta ggaccataag ccctgcggtg 71040acgcctgctt cagggctgga ggagctaagt gttctctggt tcaccaaagc ccccagttct 71100ttccgtctgt cactcatagc ttcggcttcg tccccggctc actgccagtg gtaatcaggc 71160tgcccaagaa cttctgaaat ccacagcccg gtgtttccaa acgaattatc agtagggttg 71220gaatcccttc tccccagccc cagccccagc aaggccctcc aacgccactg cagttccctg 71280gatagcagga agaggcctga gccggctctc ccggagctcc aggtgcagag tctccccaca 71340tgggagtcag tgttctcaga gcagcatttg ttgacctgag ctaaccaagt tctctaactg 71400aaagcctggc tgtgtaaagc cacagatgtc tggcattaga atagctcaag gacaggagaa 71460aaaactgaca atcagtccag aacggcatcc caggacttct gctctgagga gaaaacagga 71520ctaaacccca gctgaggtct atttccaact ccaagattct gcaatgttat ctctgtttaa 71580aaagatatcc cactttttga tgacagtgtg tctggaattg gtgggttctt ggtctcactg 71640acttcaagaa tgcagctgcg gaccctggcg gtgagtgtta cagctcttaa aggcggcatg 71700tccggagttt gttccttcta ggtgggttcc tggtctctct ggctcaggag tgaagctgca 71760gaccttagcg gtaagctgtt acagctctta agtcagcgcg tctggagtcg ttcgctcctc 71820ccggtgggtt cgtggtctcg ctagcctcag gagtgcagct gcagaccttc gtggtgactg 71880ctacagctca taaaagcagt gtggacccaa agactgagca gtagcaagat ttattgcaaa 71940agacgaatga acaaagcttc cacacgacag acacaaaccc taacagattg ccaccgctag 72000ctcggagagc ctgcttttct tcccttatct ggctccaccc acatcctgct gattggccca 72060ttttacagag agctgattgg tctgttttac agagagctga ttggtctgtt ttgacagggt 72120gctgattggt gcgtttacaa tcctgagcta gacacaaagg ttctccaagt ccccaccaga 72180ttagctagac acagggtgct gattggtgca tttacaaacc ttgagctaga tacagagtgc 72240tgattggtgt attcacaatc ccttagctag acataaatgt tctccaagtc cccaccagat 72300cagctagaca cagagtgctg attggtgcat ttacaaacct tgagctagat acagagtgct 72360gattggtgta tttacaatcc cttagctaga cataaagatt ctccaagtcc ccaccagact 72420caagagccca gctggcttca ctcagtggat cccgcccggg ggctgcaggt ggagctgtct 72480gccagtccca cgctgtgcgc ccgcactcct cagcccttgg gcggttgttg ggactgggcg 72540ccgtggagca gggggcggcg ctcatagggg aggctcgggc cgccaggagc ccacggcggg 72600ggtgcggggg caggctcagg catggcgggc tgcaggtccc gagccctgcc ctgcggggag 72660gcagctaagg cccggcgaga aatcgagcgc agcgccggtg ggccggcact gctgggggac 72720ctggcgcacc ctccgcagct gctggctcgg gtgctaagcc cctcactgcc cggccgctcc 72780gagtgcgggg cccgccaagc ccacgcccac ccggaactct agctggcccg caagcgccgc 72840tcccagccct ggttcccgcc cgtgcctctc cctccacacc tccccgcagg ctgagggagc 72900cggctcctgc ctcagccatc ccaggagggg gctcccacag tgcagcggcg ggctgaagcg 72960ctcctcaagc gcggccagaa tgggcgccga ggccgaggag gcaccgagag cgagcaaggc 73020ctgtgagggc tgccagcatg ctgtcacctc tcgacagagt cacaaagcat ttactgaatg 73080cctactgtat gccaggccct tttctcaagt ctgcttaacc aggagtgaag aaggctgaca 73140ttaccgtcca tgtcacattc tggtaggaga gggatacaga gaacactaca agtaggtgaa 73200ataggtagta ctttaaagaa tgagaacaac atggaaaagg aggctatgaa atactgagaa 73260tatggctgga gttttcattt tagataagta aatagccaaa gaagccttga ctgaggaagc 73320agccagccct gtaagaaagg agacccctgc catggtcctg agacaagggt ttgagtggtt 73380tccgcaggag gcatttccag gaggggaagg agggaaacaa cgagggaaaa gtacaaggtg 73440tgctcacccc tgaatgagtc cccggggcaa cccggatcca cctgtccagg ctcctctgag 73500cacgtgggga gcacgtggag agggagtggg ggagtcgtgg gggagcgtgg

gcagcgcttg 73560ggggagccgt tggggacttg gggagagcgt ggagagccgt ggggagggcg tggcggagct 73620gtcggggagc cgtgggggcg cgcgtggtca gcacttgggg agcgcattga gagccgtggg 73680gagcactgag ggaggatgcg gtggccacgg ctgcgtggca cccccaggcc atggccagga 73740gaccctcggg cggcgcaggt gccggaagca gcgccatccg tgctatggac gggtcccccc 73800aattggcagc ggtctcgggg gtgagccaga ggatggggtg actgagaggt ggccgatgtg 73860gggatggtgg ttttcaaata gaggcgagat cggagcagga gctgggaacc aaaccagaag 73920gttttcagga cgtggttaga ctttgaagcg gcctaaggct gtggcacatc tgacccactt 73980tctcaccaac attgcggtgg cttcttagta aggaacgggc tgaaaggggt aagggaaagg 74040gtgggggcag ggcactggga aaccaccatt gccaacatcc aggccaggca ggggcggcag 74100gggctgggcc agggcgcagg ggacccgact cttgctgcgg ccgctgggaa gagggaattg 74160ccatagagcc agaacaggag gcgctggggc agggctctgc tgtggggcgg ggtgctcagt 74220ttgggacagt gttgacactt ttggagatca tcagccatcc cagtaggtga ctccaggagg 74280ccactggata tacagctctg ggaacaaaaa acggaatcat cagcctattt acaactctgg 74340aatggatgag atggctgtga cgactggcag cagctgcgcc tgagccctca gcacctgcag 74400ggtcccatgg gaggtgaggg ctgtaaggga gcaagcaact cctctccctg gagcaggcgg 74460gcagggagaa cagaccgcca ctgtgctgct ctcaaaacca agtgcatggc cggtcggggt 74520ggctcaggcc tgtaatccca gcactttggg aggctgaggc aggcaggtca cctgaggtca 74580ggagttcaag accagcctgg ccaacatggt gaaccccctg actaataaaa atacaaaaat 74640taggtgtggt ggcacacacc tgtaatccca gctactcggg aggctgaggc aggagaatcg 74700cttgaaccca agacgcagag gtttcagtga gccgaaattg tgccactgca ctccaacctg 74760agccacagag tgagactttg tcttaaaaaa aaaaaaaaaa aaagtgcaga gttgctttac 74820atctttacat agaggagaat ggtgtaagac gcagctattt ggtcaaacct atgtgattga 74880aacatttgca tagaaagaga gagagaaagg atgggagaag aaaatataaa ctaaataact 74940ctcctttttc tttgctggct tgtgtgtttg catttatgaa caccaacatg aaattttgaa 75000ccttaaatct agtataaaaa tatggaacag ccagcttcct agagtgaggg caccattctg 75060tgtttgctgc cggtggacct agtgtgggtt ttggcgccaa tgtccttttc tgctaaaaca 75120acttggcctc ttggaaggaa acttggactc tgttgccctg actcaaactg ttgtttcatt 75180tcttatgatg tctcctcatg ttaaaaaaaa aaagaatgtg gacattatgg gtttaaacat 75240aattttgaat gaatgaggaa attctggtag agggtttgtc ataatgcagt atcaattggt 75300taggtcttct aaagaaacat gtagggttct cttaggaact ggttcattaa atctaaaagg 75360caaaaaaatt aaaacacact tttgatatat ttgttggagt tacatataat catatctttc 75420aagagcagat gtgccaaaat atacacaaca gagtgtagct gggtgacccg aactgaccac 75480gaaagtcatt tatcaaaatt caaagttagt tccccacagg cctgaatttt cagacctaca 75540cacaattcca caaacaaatg atggtaaagt cccaaacacc acattcttgg agggatccaa 75600tgctattggc actgatgctt taatcagaaa gaggctcaaa cccactggag ttaagctctc 75660tgaaagtctt tgctccttgg caaccacgag caaacctcta cagctgactt ttttagagta 75720ttttttacat ttttaaaagg attatttctg aattataaaa ccaccgttac caccttattc 75780ttgtaactct aacttattat tttgagtcaa tttataaaac ttgattcatg agagtcaaga 75840ttcagggtag gccagacagt cactcattcc taccctcaaa gagcatacac tcaaatagag 75900aatgaaacac gtgccccaag tcagaggtaa atattataag caaaagccaa agtgttctgg 75960gtcaaacact ttttgggggg tcagtgaggt cttcatgcag gggtaacagt ggagaaaggc 76020cttcaaggat ggggaagatt ttcccaggca gagttaagaa caaagagaaa gcagtttgcc 76080aggagacagg gaagcaagtg tgcagggagt gaatttgagg ccttcctaac tctgggtgtg 76140acagcagagg ggacctgccc atgagctgtc cgagatgcag ccaaaggttt caccgcccac 76200gtgataaggg gctagaacac tgaagtgtag aatttggact ttattcagta agaacgggga 76260agtactgggg gtccctgagt agagaagtgg gatcctgcaa gctgagcatc acaatgattc 76320gtcaggtgat gtctcagagt ttctctgaat ggcacataaa ccagagacag gaaggtgagt 76380ccagccgttt ctgtggccca gcaagaagta acaagtaata agtaaagtgc tatcagtggg 76440aatggcaagg gaggggcggt tacaagtcac atttcagaca ggagttgatt ggatgtgggg 76500agggcccaag gatgtgggga gggagctgtc agaaataagt ggccctctaa attttagccc 76560cagtgactta gagaaaatgg tcaagagatg gaattggttt tcagggaaga cactgatcca 76620ttctggacat gttgaattta agatgccatt aggaaaacca aattaaggca ccttgcaggg 76680aaattgcaca tgtaacatcc tggcttctgg gatttgagag gtggctgcaa agagagaaag 76740gcagtaaggg atctccagag aaggagatca cacaggaagg aagtgaggga tgggaagtca 76800ttgttgggaa gttgagggtc aaggacattt agagagcaga gggagaaaga aggggtggcc 76860attgcactag ccaaagaaaa tgttcagcca ctcgccctgc agggaaggcg aggggcaggg 76920tggctgcgca tagatgtgga attagccgga ctcagggtga agccatgatt ctgctagtgt 76980ggtcttgtaa cctgggacat ctatctgagc gccctgtcag cgcttctctg cattgtaaat 77040gggagttgtt gcaagggtga aataagacgt aaggtgtttg gtgcaaggtc ttgtgacaac 77100tagcactaag gaatggtgcc tatgaccttt attaggcagg aaggagtcaa cagagtgagc 77160tgctgctgca gggggttggg agctcttgca acggtggcat cgagaaggtt gtcaacacag 77220ccctgtcaac ggctgagggt ggcagagtcc atattgcaaa ggagcacggc ataagtggcg 77280aggcaagaag tagatggatg ttctattttt tcctttctct atctggacaa aggtcttttt 77340ccttccaagg tgtagctgga ttttctctct atagagcttc cctggggcgg ttccattttc 77400tagtgtctcc atgagtcttt gttctttata tgaggtccca atgatgccat ccactcattt 77460gctttctcac aggcatgttt tccaccagcc acccacgctg attagcttga gagtgactca 77520aggcaggaac gatgcccttg tcgtagaaca gcctctgatc gagtgcttgc tgaacagctg 77580gctagctctg agcatgaagc aaaatgcagg aagctggggt gtgtgaggag gagcagggac 77640agcttaaaga agagaggagg gagaggaggg ggactcctgc ttggggcacc ccacctcctg 77700gatatgagat cacttgtgtg gagcaggcct agtagcaggt aagtgggccg aaggggaggg 77760agtgaaaaag tccatgtatt gagtcacctg aggtgtcatt taaagagaca ggaataacaa 77820aacatcaatg ggacctaagt tgagattaga attaccgact tgacttgtag tgtcacctgc 77880cacccagggt gaggaatgtc ccttaccaca aggtcacctg gggtctgaga tttgaaatct 77940gtcagccttt ctgggctggt ctcttgcctc agtttatgct cacacagctg cctcaggatc 78000agtgtggaca gaaaggtacg tgagactgtg caacggagat gggctgggag aatgaggaag 78060aggggaggga caggaggtgt ccatcacctg gacacgggac tgaacaacca cacaacctca 78120tggcggacac cagcacacct tgacctttgc tcataagtct gtgagtcggg atggggggct 78180ggcgacggct catcctgctg ggcttcctac gtgtctgaga caaccggatg gactggtgcc 78240ggctccgtgt ggtctctctt catctcgcag atttgcctgg gcttgtttcc cagcagacag 78300cttctgagga taggtttggg acgggcacct gccacttcct ccacattcca ttggccacag 78360tgagttgcaa ggctggccag actcaggagt gcagagaaat accctctact tccagatgag 78420aagagccaca aagtgacatc accgcaggct ggatgcaggg cagggcaaga cagcggaacg 78480cgtgggctgt tttgacagtc agtctacccc aggatgctcc aggaagggga aaaggacaag 78540ggaagagggg cgctgtggcc aagcagggga acttctgtgt tcaaaatctt ggagatggat 78600cactttcagt tcccgataag gcttagtgta tggccctgag acttgccgtt tgatactata 78660atctgtcata tacaatgtaa cttagtgaat tgggtaaagg atcttcaggg tttattttga 78720atggttgtca tttattataa aattaattta ttttataata attttatcta attggctggg 78780catggtggct caaacctgta atctcagcac tttgtgagag cagattgctt gaacccagga 78840tcttgagacc agcatgagca acatagcaag acctcatctc tactaaaaaa aaaatccaaa 78900aaattagcca ggcgtggtgc catgtgcctg tagtcccagc tacctgggag gctgaggtgg 78960aaggatcgct tgagcccagg aggtcaaggc tgcaataagg tatgatcatg ccactgcact 79020ccagcatggg caacagagca agaccctgtc tccaaataat aatttgatat caatttgtaa 79080taatttattt taaaagaatt gtatgaagga cccatgcctt ggggcatagg ggcactgata 79140gaaggtaggt gatcagtata gatatttgct gcattaatct atttcagtca cctgtgagat 79200gattcaggta gaaggaaagt gaggccccga gaggtcaaat gtttgctgag tcccacacag 79260gtgaacacac ttttctcctg gatcctagtc taccccacct tcttttctcc ttttgaaaat 79320taatgttttg taagtgatta aaaagaaaaa tgatcgggct gggcatggtg gttcatgcct 79380gcaatcccag cactttggga ggctgaggcg ggcagatcaa aaggtcagga gtttgagatc 79440agcctggcca acatagtgaa acccccgtct ctactaaaaa tacgaaaatt agtagcgtgt 79500ggtggcacac gcctgtaatc ccagctactg gggaggctga ggcaggagaa tcgcttgaac 79560ccaggaggca gaggttgcag tgagccgaga ttgtgccact gcactccagc ctgggccaca 79620gagtgagact ctgtctcaaa ataataataa agaaaggaaa agaaaatgat tgaagacaca 79680gtgacattaa gtttcataat ttttatttaa tccaagtcta tccccaaaag gattatgcct 79740actgtactat attatacggc atgaaataga tgatcctgta acataaggga tcagattcta 79800tgccaacttc taacactgtg gcttaagaag tcagacccaa gaatgttgtt caattatttt 79860atcattagcc taatttattt ccaccctgga tttttccatg ataactaatt ccacacttcc 79920tctggatccc ctctttcagt ttcaggattc aggaatggct tcggggaaag agcccttatg 79980tttttgcttt caatccactt gtgtttccct ttgtcaagag acaaatggga actgcacccc 80040caaactgcat gatgttcttg gcagagaaaa tccccagacc acagaggagt ggtatctgca 80100gaagatagaa cgagaggaag cagctcaaag acaaggttcc agaatgagct tgcaccatgg 80160gatgcagcca gtggacagtg actgaccagg aaacacctgt gatggcaagc ggcagtgacg 80220agcgagtcag aggtgaccgt gccggaattg aatgtgcgag cactgctgtt ataaaggaaa 80280agaggaaagt gcaggcaagg acttttattc tcatgtgctg attataccaa ttcatataga 80340tgacgtctgt gtgggcattc agatgggcat tttcagttca aatgattgtg tgaacatgaa 80400tcgcctaatc aaaattagat ctttattttc tcctttccca gtcgtaccct cagcccaaca 80460acatttaaag gtgaatggat gtgcaatatt ggcacgaatg gacgtgacac acagtaggcc 80520tttgtgcacc ctggaaggga gggcagattc tgcttcaagt gtgctggaag acatgggagg 80580gatctgaact ggctgacgct gcactgtagt agggagaatg gagtggaatg aggggaagga 80640tgccaggggg aggccactta ggaggctgct gtgtagccca agcaagaaag gatggcgact 80700tttctatcag gggaagggat gagaggaggt tggactgaga ccgggatatg ctctgaggtc 80760aaggcgacag agttgctgaa ggatggaatg tgggctgtga gatggaggag tcctggcgag 80820tgctcggctg gttggcctga gtgtgtggac ggctggtggt gccgtttatc ggtgcagaga 80880aggctggtgg gagggcacct taggggtggg ctgggtgggt ctgttcagga aagaccacgc 80940tttgatcatg ttggttttga ggcatgtgca ggctaggcat gtggagatgc agagtggatt 81000tgagtgccat cggcatgcag atggactcag gccatgcgat cttgtgagat gccagcccag 81060gtcttgttcg gaagaggcag agtatgtttg gctgcaatgg ctgagtgggg cttagattca 81120gcaggaggag caggccatgg cagggtgaga ccttctgttt gagaagctag gcatggggca 81180tccatggcac agccctggga gttgccgcgc aggcagcagt ggatgtgagg gtggaagtca 81240aagttgagga tgtagatgag ggagctgaag tcatgggggg atgagggcac ctggggaagg 81300ggtgtcaagc aagagagcgg tgcacagatg agaactctga cctttatgag atgggagaca 81360aacgtgcgga tgaaaggtgc ggtgtcacac aaactccagt cgagaggcaa taaatatctc 81420acatctcagc tgcatcgtcc tttctaacca agcatggaaa ttctgtctgg caagccgtca 81480ggtacatttg cagaaaagga gaaggaaagt cattgagggc cacactggag tgagacagga 81540tcagcaggaa gggaaagaat caagaccatg atgtttacat gacttctggt tacttctccc 81600caagctccag aaggcaaatc ttgcatggac ctctggcatg catgggtggc tgcagagagg 81660cctagagaag aggcattcat ttggggtgag gctcctcctc tctttcaggg attttacagg 81720gatccttcca gccagtgggt ctgtgctgga tcctccacca gacaccccta gtcagggcgg 81780aggccctcag cactccagcc tcagagccca gacagttctg gttcccagct cccttcctgc 81840catgtctgtg agtccatcct cctgttccac ctcaggactt gtaaggcgta ttactgtgcc 81900ccctgggtaa ggcagagttt gaggaagaac gaataaggtg agggccactg actttcagga 81960tttagctcct cttctcaaca tgcatttcct gtctactgtc tgcttcacat cacccacccc 82020tcactgtccg aaatgcgtgc cccagcccaa catcagcatc acccaggagc tggttagaaa 82080tgaggctctc aatctccacc caacctcctg aatcagactc tgcattttaa cgagatcgcc 82140agagagattt gtgtgcatgt tgacatttga aaagcattat taggcacagt ggctcacgtc 82200tgtaatccga gcactttaag aggccatggt gggcaggatc gcttgaggcc aggagttcaa 82260gaccagcctg ggcaacaaaa gaaaccccat ctctacaaaa tatttttttt tttgagatgg 82320agtctcactc tgttgcccag gctggaatgc agtggcatga tctcagctca ctgcaacctc 82380catctctcag gttcaagcga ttcttctgcc tcagcttccc aagtagctgg gattataagc 82440gtgtgacacc acgcccagct aatttttgta tttttagtag agacggggtt tcaccatgtt 82500ggccagtctg gtctcaaact cctgacttca tgatccaccc gcctcggcct cccaaagtgc 82560tgggattaca ggcatgagcc accacgcccg gccaaaacat ttttaaacat tagccaggtg 82620cggtgcatgc ctgtagtccc agcaactcag gaggctgagg tgagagaatc ccttgagtct 82680ggcatttcga aactgtggtg agctctgata gcacctaatg catgccagcc tgagtgaaag 82740agtgagaccc tgtcaagaaa gaaagaggaa aggaagagag agaggaagga gaaggggaag 82800aggaaggaaa gaaggaaaag cagtatcata tattatttaa tgacacttca cccaaggttt 82860tccaaataaa aacatccaaa gaaactagac aacaagcatc cttacctttc aataaaggac 82920tcacttgaca attttaggta tgtgccaaag caccaaagca aattgttgat gttcagctta 82980gtaactgaca tggcttcaat acctacccgg catggtgctt cgctcactct ttaaagacta 83040cctttatgca cttttactat ttcactgcca cgctaaacat ctaagcgatc atatccttat 83100gcctactgat tatgaagtcc atgacattca acaacatcaa ccctttgccc actgccccac 83160ccgacttgaa ccaagttttc ccaagttcaa ttcctggggc ctttgatagt ttcatgcctt 83220ctccacgtgc cagagacaga gaagagtgag ctctatcgtt tttgggggtc tactagtttt 83280gcctttatta tttagacagc ttcaggtcag cttcttcctt gtataccagt cacaagtggg 83340tttttatttt acaaagaaaa catagaagtt atcattttct agaaaaaggt acaataacta 83400tttcaagaca tattttagat atacttacag gcacaccttg gagcagttca ataattaaaa 83460atttcatctg tctgcctgac cgccaatgca aaggaaacat aattaaaagt ttttttgttt 83520cttctccaag ataatagttt ataaagtagc ttaatgaaac actgaaaatc cagaatggaa 83580gaggacgtgt gaaatcccct ttccggtgtg aacttattct taaacaatca aatgaaagtg 83640cccgtcagcc tttgcaagat gctaaccatc tggcccctgc atcctgtctg agtcacccga 83700taaatagctg caggttgttt taagcacact gcgccctgca caagctgttt tgctctgcta 83760ctcactgccc ttaggtgcag atatttacac ccggggttga gcatattttc agccacacct 83820ggatgcctcg aggtaattag gaggaaactt ttagcggaaa ggaaacagca tacctttgag 83880tagcccgatt gtgtatgcag gagaaaggtt aagtaggaag agaggggagt tctctcctga 83940attgagtagc tttgcttcct attggaaaag tgtgcaaatg aaaggaagta gaaatgctaa 84000aaagctctgt gactgcctcc tgctgtattc aattagcctt ccagaggatg ccagaaggaa 84060ggctcaatta ccagagcggc tccaggactt aagagaaggc tggagggcaa accaaagggg 84120ctgccatctt gcagacctgg tgtgagacca aggcggggca gctgtgtgat tggattatac 84180acgggaacct tactttagtt tctattgcat ggccagagct atgcatgcca ccttttgcat 84240ggagtcttga aaagtcacct aattttaata aagcagaagg ggaaagcgat aagaagaggg 84300agagtgcatc tctctgaaat gcctaagcat cggccttgcg ggaaccggcc tcatcgagga 84360gcagggccac caccgttgga gcatcggagg agcatcggag gagccctagc tctggcctct 84420tggctggacg tcactgtttc aggccgagca gataaaagca gaaggcattg accgtgagcc 84480aagagctcag tgttttcaga aaatggactg gacgggagga aagagtgtga gtgtgctttg 84540agagcaataa acaaactatt ggctgccggc cagggaggag tgtgctgaca tcttcaagcg 84600gatcctcgaa agctccacag agcggctgag gaagcctcct tagggctgtg gatggggtgg 84660cggggcaagg gctgccgtgg cgccatgcag cagtgggcat cgggcctcag ccacacccag 84720cagggaggcc aacagcagaa tcccaggcaa acgcccctag ggttcgcccc tcatgcctcc 84780actccctggc ctggctctct gaagggcagg gcggtggagg agaagcagag ccaggcggtg 84840ccctccgcca gctctagctc aaaggctgct ggggctgacg ggtggagctt gtgtagacga 84900agccccttac cctggaagtg aaggttatgg ggtttcctgg agggagggca ctgggcctcg 84960ctcttaactg aggcttcccg tcccccgagg gagggtgatg aagggtgtcc agacacatcc 85020acggggacaa aggaggttgg caaggctgac cgcaggagtt tctcctctaa tgcctttcaa 85080atgaacaggt ctgtgtcgct gctccgggag cgcctgcgct cacatacccc gcggtgcaca 85140gttaccaacc agatcctacc acgccactgc ggacatcgcg gtttccggga agtctctggc 85200cttcgtatga aaagacagcc cgacaggttg aattctttaa aaccttatct ttggttattt 85260taataggata tgacaatctc ctctcctcag catgtcgata aatgtttatt gccctttact 85320gtgtgagagc aggggtcctg ccgccgcttg tttttatttt cttttagacg gcgtgaacat 85380ttttagcacg tgtaaccaat gatggtaatt aagattataa taatgctgat gccaacattt 85440atatcagtgg atacagaaaa tacacagcct gattattttt tattactcgt acccataaaa 85500ttaaagatct taaacatggg atggagggtg catccgcatc aagattttgt tagcatgaga 85560ccgaacccat tcagccacgg ccttcatcag aagccttttg agtgatgaga cagtgatgag 85620atagctcgcg ttatcctgca gcacagagct gcgcctggtc acggcagggt gcaccggctc 85680tcgggcttca gacaacagct tatcagtacc ttgcccgtgt gcaaggacag tactccttga 85740tgccctgaaa cctccgctcc tactaactgt ccttggacac gtcggcatac agagaatcaa 85800tcgtactctc agcagtggtt tctgcagcaa ctctgggtca tggaagaagc caagtgcatt 85860gttgaaacag cagagcccag gcagtgcccc gatagaaacc aggtattgag tgcttgcacc 85920cgttcctgtg caggcgggcg tcacgcacac cttctgctgg aagacacact gtctacgtga 85980acgcccagcc tccctgtgcc ctgccttgtc ttgtggaata tgtcggcacc cccaaagaat 86040acaccttcaa agccaaaggg gagtttctgt ctgtctgctt cacactgtcc ttcctcctct 86100cccacccctt ctctgtgtga agaagtaaag caaagctctt aatgatcacc cttaaatggc 86160aagactttga tagactgttt ctataatagg ttctcattga aacatgggag ttctaaatag 86220agaactgtta aaaagtggaa tgagagatga gggaccgagt cgtggccctc cttcctggtc 86280tccaccatgt caagtatgcc tccaccccgg ggcctttgca cctgctgcgc tgctcttcct 86340tcaggtcccc acagtaggcc ctttgggaac tctgatcaag tgttgccttc tccgagaggc 86400cgcctctgac catcccctgg aaaccagcct tctctccccc acgcctgggc tattcctccc 86460ggttcttatc ttcatcttgt gtttcatatt tgttttactt gctgatcacc agaagaaggc 86520cttataagtc caggcactca ggcttcctct ccactcgatc tccagtatcc agaagcatat 86580cggatgagga ggagaatgca atagaaatta gtcgcagaaa tcaatcatgg agaaaggaaa 86640tgttctcagt gaggtgtttc aaatatgcag cgtacaagac ttaagtggaa gactcactta 86700taaagtagct gactcgccca gcagaggcac ccatttttat actttcccct ttcacctttc 86760ttgtggataa agccagtgtg atggctggag cttcaggagc cacgttggac tatgaggcac 86820cttgaagaca gaaaggtgtg cactgaaaat gctaaagctg aatgacggtg ggaaggtggg 86880tcctgggaag tgatggaaac cccgtgccag ccttggaatg cccacatctg tctagtttca 86940tctgagagaa taaaacatta tatatgttcc agccattgtt gttttggctt ttctgctata 87000tatagttaaa ggtttcctat acatatatca gagaaccatt gggattcaat tttagtcact 87060tattataatt caacgaatgc actttacttc tctgagcaat gttatgcctt cataaagcca 87120ataaaacagc gtaattgttg aagaaattgt gcaaatatag aatacaatca ttcaaggcaa 87180cctagtctct tagcctgcga gtgttctaga tgtatacaag acaaatgcat tcattcaaat 87240attcaacaaa tatttgttga gtacctacta ctatgtgtcg tgtattgtgt taggttcact 87300aaaacacagt aggaaagagc tggaattgga ataaatgctt tgaattctga ctcactgctt 87360attagttgtg accctgagca aggtgtttaa cctttctgag cttcagtttt cttaatagca 87420cttagttctc agaggtgtgt gaatatggaa tgagaggtag ataaatgtct gaacagagtt 87480gctcagcggt tacagtaaca cagttttgct agctaccatg tctgcaatgt gatcctttcc 87540atcaaggagc cccctcgtgg gagaaacaca gataaacaga taatacagtg aaacttggaa 87600ggtgccgtaa cagaagggta agcagagtgg tttgagaatc tggagaagtg ggtcactagc 87660tctgtttagg tgagttgaaa tcaggttgca ttatagtcat tggaagcatt cactggatat 87720ttccagtttt ccttctcctg acacatggta gagttgtctt gaagagtcag tacaagtctc 87780tagatgaaga aagaggtttc aacactctag ggcaaatgaa atttttatgc aaagccgagt 87840cataaaagga ttaaaatttg gtgataggat cagtgcaact gtgaccaacg ctgggttcat 87900ggggtggtag aaggcagaag gtgagtctgg ttaggtagat agggttgtat atttagggca 87960cctttgtgca aggtgaattt ccccagagta atttgaactt gaaaaccact catcaaaatc 88020tcctgattca ataaataaga aggctggaga aatgtcacaa acttctttgg aaaggcgtat 88080gggacctaag agtgatctac atagccaatt tgttgctcat ctataaagac aacaggcaaa 88140ttacctctca aatatgagag agctcaggga acagagcata ttaaaaagtg tctggaaaga 88200agttttgagt tgtttgtttt cagtaacaaa atccaagcaa ttaatagatg gttaaaaaat 88260aagcatgttc aaagaacggg tggcatgaaa tggatcaatg taaatgaagg ataagtattt 88320taaactcata ggaattacat tacagaaaaa atgtattttt ttaccttgaa aatgcagaaa 88380ataatgtaac tgacaaatgt taaggtgggg aaaaaggaga aaggagaggt gaatggaaat 88440gagatgatga atgtcctcag atttcaaagg aagaagtgaa gcaatgctgt atagcattta 88500aatggtattt ttaaaaatgc ttctaacttg ttgcatacct ttcctcaagg gatcttttag 88560gaaatagtaa ctcttggtag ataaacattt gtttttaggt tcagcaattc

tttgtctttt 88620cattttatgt tctcctcctt acttgagcta ggtgcacttt atgtgctcta ggaaggctta 88680ggtgcagaca cagggagggg tggagcggga gggacagggc cttgaagatg tgtctgggga 88740attaggcaga agccagttca tatagtgcct tatgtctcag gcctaccacg ttcaggaact 88800ttgacttttc ctaaaagata atgggtgagt ggggaggaag gagaatttga attatacatg 88860catttatttt ttttttcttt tttgagacag gatctagcta tattgtgcag tttggccccc 88920aactcttggg ctcaagtgac cctcccaact tagcctccta agtagctggg actacaggtg 88980ccagcaagag ggcccggcta tttgataaag atcactttgt cactttggct gtcctgtatt 89040taaaaacctc tttaagcaac atgatttaga gctgctctat cagcatgatc ttatgatctt 89100ataatcttat gaatctggac tattcaggat ggacctcata ctctgatcct tccttcaaat 89160ttcagatctt tccttcagat tcctaaatac tactttggta aacactttac agactaaact 89220aggcagaaaa aactatggtg attctttttg ctgattaaat ccatgctcag tagttctctt 89280atcctcagag aagccaggat ctcaggcttc aggccatgcc ctgtgcaagt ccaggggagc 89340tgttgacatg agcaacaaag ggggtggctg cctcctcagc tgtgcgatgc tgagcccctg 89400ggggaagggg ctggtcgaga ttatgtggtc tatgtcccct ctcccatcac tacgaagaaa 89460gacagctgca aagtcctatt ttttaaggcc tccaggcaat gaaatcaaca attatttcaa 89520agttgatatt taataaccct cgttattatc aaattatttt ttatggaaat cggacacatt 89580tttctaattg tattctaccc ctttctctgg ttttatcatc ttttgaggag gtcagctgac 89640taatctttat tttatctata gcccctaatg ttatcaatgc taatcaatca ccacgtagtt 89700tcctcttttc cagtctaaat agtcctagct ctttgatgta ccttcaaatg tccaattttc 89760caatccttta tatcttgatc ttttataaaa cagcttccca tgttgcacaa aatttaataa 89820caaaagcaaa gatacgtgaa gcctatagtg aagcaatgac gccatcctct ttttgaccat 89880gctagattca taattttgtt ctacttttac cctattttaa atcccccctt tcaaaatcgc 89940tgtagatgga gatcatacat tagagatata attgcatttg aaaaggatgg ccctttcatt 90000ttctgctgtt atagcagaca ctgttagttg ctactgaagt gacagtactc ctttttcctg 90060gtttccaatg cccagctttt gttcaactgt ctcttcatgg gatgtggaca cctcccagcc 90120ctggagggtg catctctttt agtgtaaatc agccatctcc ttcctcataa tcaatggaac 90180caggagcttg ggacccaatc ccagacaatg gaagtgaggc agaggcagct ggtggtgggg 90240tggctctggg gtcatttgca tcattccaaa aagacacccc aggaagagac actgctttgc 90300tggacattgt tatgagatga catgctgcct ggagctgccg caaccatctt agaaacacag 90360ggggccaagc gtctgaaatg aaagcaaaga tcgggaggat ggctgagtag aaagatgaag 90420agatccaggg cttctgtgca cgccacttag ctgcctaatt aaccagccct gggcttcctg 90480ttgtgtgagt taacacatcc ctttgcaatt tagtgatttt cactgtgtgg tcccagacca 90540gtatcagcat catctggaaa tttttagaaa tgcagatttt ggggccctac cccagacttg 90600ctgagaagag tctaggagtg gagtccagca atctgttttt aacaagcccc tccagataat 90660tctaagaagt cctgaagttt gagaactact gctctgagct tgctacagtc tgaatgtctg 90720tgtcctccca ccactcctat attaaaattt gaatccccaa agtgctggta ttaggaggtg 90780ggggtcttta ggaagtgatt cagtcatgag ggcagagctc tcatgaatag gattagtgcc 90840cttatgaaag ggaccccaga gagctaggtc aacccttctg tcacgggagg gcactgagac 90900agtaccatct atgaagcagg cagcaggcct tcaccagaca ccacattata gcagcttgtt 90960cttagacttc tcagcctcca gaattgtgag ggaaaaaaaa tactattgcc tataagctac 91020ccagtctatg gcattttgtt atagcagctc agatcagcta agagccattg aattgaggtt 91080tcaattactt gcagctaaat gcatgctaat taatacagct cctttattgt tttatgcatc 91140ttttctagaa aaatctatca atcagtatgt tttctgtcaa tgtcatctga gaattaagtg 91200tcataaccag aaagatctgg agagacagga gcacgttgta cagttcctga tatgtatttg 91260acacacccag acaggctgga aaagagctgg ggtaggtttc ctggggtata agtaattttc 91320gtaaaaattt agaacttttt gagttccaag gtgaaaggag aggattttga aatgcagaaa 91380aagaaaagtt cagaggcaca aactcagaca gagctcctgt cagaggaacc aagtgcctaa 91440aataggacag agtctccaga tgcagcggaa aggctgtgag tcatctgacc gctcaggtag 91500gaaagcggga ccagtgtgaa atgaaggagg cactaatgat aagaggacaa gaaaccacca 91560aattgctatt tagggtcatt gggatctgca gagggaaaca aggctgaaga gacaagagga 91620aagacacagc tgtgagggtc aaaatctaaa aggagctcct gaagggatgc ttaatgtttt 91680caagctatca actgcagcat gctaggtcta tcatctgtgt atcattgcca aagcaagacc 91740cataaacatc agatttcact tggttataga attcagagaa atactactgg ggcaatgaca 91800gggaagagac actgcacatt ctcagtggag gaatcgtccc ctctgtcctt caactggtgc 91860catccaaaag ttgctatgtc aagtaatgct agcttcactc aaatgctatt acccctggtc 91920aactcacagt gatatgcact aatgagcaac ccatctaatc tgtgaagcaa tgcttaagga 91980aggtttgagg aaggacgagc tgcagatcag ctcaaggatg ggactcaaat atcatgacag 92040taccatgagc taaggtgcct cttgcaagct gcctgtcgag gccatcagtg ggttagaacc 92100aaattcttcc aaaattattg cagcctgcag tcttctcatc ttgtcatata acacttaaca 92160ttctggaaaa ggccctgcat tggttttgag tggtatttcc agaatctgtg gacctttgaa 92220acaactccat tttgctgtac tttctccaca atggctcttt cagataaatc acttgtccgt 92280tcctgcctta gatgaggcct gtggaatgac tgcatcattt gccctttcat tgttgaaatg 92340gttatcagat ttcaggtata tcaagacttg cagatcaggc ctcttactct gtgtgactaa 92400caggctcccc cagaacaaac catccaggca caaacagggg atgcagcctg tggctatccc 92460atcacaggtt tccacaccac agtgtgagtc catcttgctg acttaacaac cgtaatttaa 92520aaatcacctt ccaaattgca ctgattttat ttgttcaaaa gataacacac acattattac 92580atgactatca ttttagggca aagtggatgc acggacaaat gtttcaagca aggaggtaaa 92640actctcctgg ataaaaattc acagcatcaa ttttctattt tctgcttcct gaattgcatt 92700ttcctggatc tgatgatttt cttctttgta ttcttgatgt atgcatcggt atgtcttctt 92760ctgtgtttgt gtcatggagg cagcattctt cttctttttt tttttttttt ttgagacgga 92820gtttcgctct tgttgcccag gctggagtgc aatggcatta tcttggctca cggcaacctc 92880tgcctcccgg gttcaagcca ttctcctgcc tcagcctccc gagtagctgg gattacaggc 92940atgcgccacc acgcctggct aattttgtat ttttagtaga gacggggttt ctccatgttg 93000gtcaggcttg tctcgaactc ctgacctcag gtgatctgcc tgcctcagcc tcccaaagtg 93060ctgggattac aggtgtgagc caccacgccc ggccggagga agcattctta atgtatgcat 93120tggtacatct tctgtgtgca tgtcatggag ggagcattct tgatgtacac gttggtgtat 93180cttctgtgtg cacatcagga agggagcact aagcagaggt gcataagcag attctggact 93240gcagagctgg ggagcggtcc tggttttacc actcatggac tgtgtgctct cacacaagtc 93300tcttagcatt tttgtacctc gggctcctcc tctgtagaat gaggatgaca attcttacct 93360cctaagattg tcatgagcta tcaagaagtt aatatttgtt atgtatttag aatggcatcc 93420agcacgtcat aaggactctg ttttgtagag tacatcgaat gttctgtttt gttatataac 93480acatttactt ttcataaatg ttgttatctg gcaggtattt tttggcttcc agaataaaag 93540ttttaaaatt aaaaggggta tccaagtatt tttaggagcc tagtatttcc tcacttactc 93600ccaaactcta aaagtagatt ggctttatgt taaacagaga attcgtacag aaaaaatctt 93660caggactgta ttcatttcat aaataatgta ctttatttta ttgcatatgg ctattaagga 93720gggcatccat gatcaataca gactaaatac aatgcactat tctagtccag tttattctcg 93780tctccagcag catcacattg acccctatat acagcgtgta cagtggaaga cagagcaaga 93840taagttaagt ctcttgtcat atcacaatag caagaaatat atttaacatc ttgatatcca 93900gaaacaatac gtacccaaaa agaaaacact gtttaataac tgttaaagtt tatatagcaa 93960aaaatatttt aaatttaagg taagtcaggc aaaatgtaca aagacccaat atacattgtg 94020aagttttagc aaacataaca tttatacatt ttggttccat tctgtaaact aaattaaaaa 94080tgtaaatatt gcatatgcct ttttgtgaaa tgtacaggat agaggaaaat ttagcatatt 94140atcatctgtg tattttgctt gttttaagct gcagtatgaa cacgaaccat ctgtatagtg 94200tcatgactac tctacggata gagggcgagt taaatatgcg tcaatacact gctttcagca 94260gggtccatat tcagtcccta tcgtacctgg ggggagttac aaagcaaata ccacccattg 94320atgcctattc ccaaaactaa ataaaaactt caggattttt atacatctta ataaagtata 94380tcatacactg aaattgacct tccagctaac attatatggc ctatgcactg ctgtgatgta 94440taatttcaga aaagtaaaac cttaaaaatg ttcagggaga tcactttaca ttcaactttg 94500tcttgcaata caatcctctg ttctaaagtt cagcacggaa gcaggaagac ttttgcattg 94560ccattaaata tatttttaag acattgaatt ttttggtctt cctctaaaaa agcctcattt 94620tattaatgca ttattctata gcgatagata tctattatat atttatatat atttttctaa 94680aaacaaaaca aaacaaaacc aacaacttac atctccaatg aattagtgta acctctccat 94740gactatcaga gaagataggc actggggaag cccccacggg aggagaggtc gacagccctc 94800caatcaagtg tcgagggagc agaaaacggc agaacattct gccggtcaag ttcagcagtt 94860ttaggtaaca tctgcgagaa ctgccacaca ctggtatttt cagaatactg aaaacataaa 94920acaagggtag tcttgtccgg aattttttcg acaagtaaca tgtactgcga gattgctttt 94980cttctttttc tttttccatc aataacatag gggctggaat gcctcttttt atcagtttct 95040ttctttcctt tttttttttt ctttttgttt tttttgttca gggcagcctc actggttgac 95100ataataacat tttattaaag ataatacgtt ttttaaaaat caaatctgcc aaacccggac 95160caccctggaa ttgctagcac gcctacaggg atttttggtt acagaaaggc atgcccaaga 95220ttcaggagag cagagacatc tgagcttgta aatagaataa aaggcgtttg caatgtgaag 95280tacctacata aacatctaca tcgagaagat taaacaagtc tgttaaaggt aaaaagagat 95340attcatcccc ttcccaaagc ccttccctcc cacctcccac tacccaatac agttgatttt 95400caaaagtagg ttgcttcagt tacatataat aattattatt tagtaatccg tcttcaaagt 95460ccaatcccaa atttcacttc cattgagaaa tgtcagtccc acactgggct cggtgtggac 95520gtaaacatcg caggtacctg cactggaatc caacaagcag ctgtctactt ggaccatttc 95580aataaggccg aggaccgcgc tccagacaca cagcgcaggg gctactacag gaggtcctgt 95640gggacccccg ccacggaaat ccggctttac cttgaactga ggtaggactg tggtcgtttt 95700gagtgtaagc cagtaaatac cagattttac cacttccata ggtacgggtg cactctccta 95760gcatgctgag ggttatatct gctttgccaa aaggaaaaga agaagaaatt aaaagacact 95820ggccacaatt taagaaggcc aatgaaaaca tccaattttc ttgagaataa cttcttcagc 95880taattttgtt aaaacaaaac aaaacaaaac gcaaacagca caatgatgaa tgccccatcc 95940gggaacaagg gaaagaggca ggtgaccttg ccttgttggt gcctcatcta acagagtcca 96000cagatgtttc caaacacagt cattgctcag atccaaaaga aaactgcaag cagcttcggg 96060ctgaaacagt gctgagcgtc ttcttttaat gatactctct gacatgtgac atcctggtga 96120taaagccaga cagatcttca ctctgaaaaa gaaaggaggg aagttagcag agaccctcag 96180gagaacagag caatctctgg agttccagaa agggcccctc taacccacag ctaggacctg 96240ggtcattttc ataaactgat gacctttgag aaagaaacat gtattcattc tgttttccag 96300aggtgagttc agtgggaaaa ctctgagttt tcctggaagc agagctgtta ggttcatggt 96360gagttgtcta gacagttagg ttcgtatttt caatttaaga aaaatattcg catgtgtttt 96420tgtgaatcat tctgtcgaac aagatagaaa aagaagggcc agttcctagg ttgcactgcg 96480tgtctgtgtg atggaatgac ccctgtaact ccttaggcct tgatgcttcc tgtgttgtgt 96540gggatacaca gaatccactt gccttcctcc cagggctgca gagatgaaaa actatgacac 96600acattacaat gctctgtaaa ctatgtttat tctacaaatg tgcattatgt tatgaaagtg 96660gagtaactaa taactccaca cttctgccct cagaaaactt ccaaccggat catctacctc 96720tttttgaacg tgcccagcaa tggaaggttc ctgcacggcc tcatgtgttg ttgcataacc 96780ctcaacatta ggaaagggtt atttttatcc actcaaactt tcatatgttc cagtttaagt 96840aatttaccct ttcgctgtgc tcagagggga cagggactga ggacacgtgg ccagatctaa 96900ttgcttcctc ccttccagga tgaaggatca aaattcttta acctttctca atttccagtg 96960ttttaggcct atttttactt gatatattcc ttcttcaagg gacagaacaa attggaagat 97020tttgaccttt cacagcgtgc tgttttcttc tttctaagct tcttggcttt ttaaccaaaa 97080tgacatactg ttcattttca tcactcagca acatgagggt gagcaccgct ttgctctcaa 97140acaggtacat ttccttcctt tgcagatgca tttataccaa ctgcatttct ggacactctt 97200ctaaaatcct ttagaattct gatcctagcc tcttatcata ctccctgact tacttttttg 97260tgaaccaaat tcttttctct ccatcttaag tttagaggac tgaactcaac aagacagaaa 97320cttccagtgt gccctgaagc tgagagtgag tccctcaaaa ccacatctcc ttatgaactc 97380gaggcactac atgctatagc cccccaaaaa ccccaaaagc tttacagaaa aaatacttgt 97440caatatacaa agtggacatt ttaaaattcc ctacaacgcg acattctgag gctgttttat 97500ctattttatt tattattatt attagtcttt tttaagatgg agtcttattc tgtcacccag 97560gctggagtgc agtggcatga tcttggttca ctgcaacctt cacctcccag gtttgagcaa 97620ttctcgtgtc tcagcctccc aagtagctgg gattacaggt acgtgccacc atgcctggct 97680aatttttgta tttttagtag agacggggtt tcaccatgct ggccaggcta gtcttgaact 97740cctgacctca ggtgatccac ccacttaggc ctcccaaagt gctgggatta caggcgtggg 97800ccactgcggc cggcctatct tgttattttt aaaaagcttt atgtccatta taaatttaat 97860aagtaaacaa tgttctgcca atgaacctta acagaattaa tttcttccta aggaaagatc 97920tgtctttgag ttatctgatt cattattgtt gtgattttca atcccaggag acttcagtga 97980gaatctaatt gtttgtatcc cctaaaaaaa aacaggcatt tgctaaaaca caccttgaga 98040cttgtaattc accctaaaat gagcttgcat tttgtccctg agaccctgat ttgggaagaa 98100tcccatggcc accacaagca ggtaactgag actctgcaaa tccattgaca gaagaatttc 98160taatcaattg cttattttat tttgacacta acaattagct aaatgtggct gaattatctc 98220atgttaactc taagtctgtt attttgaaaa cagctaaact agtaagttct tcagtttctc 98280aaacttaagc actttgtcat ataaatggcg ggtaaattat tgctgaaaaa aattactttc 98340cattttcatt tgtgatttca tgaggccact gacattttca ttgttttttt taggatgctg 98400tatcgctgta atattcaact cttatcatta catctttgcg agctccaatt aagttgaaca 98460tgtaatttta ttttttggaa gtagaataca gttatcaaaa cgttaatttc taagcattag 98520cattatgcaa gaaaagagct gataaatggc aaggaagtaa ttcatccatg catttattca 98580tgcaatgacc tttcaacaat tttctttttt taattctact ctggtgcaag gcctcactga 98640taacttgggg gaagatggct gacaaaaaaa aaaaaaaaaa gaaggaaagg ggaaaaggaa 98700gggcaagcgg aagaggaaga ggaaggggaa gaggaagggg aaggaaagaa aaaaaaagaa 98760ggagggagga aggggaaagg gaaggagaag ggaggaagga agggttatta caggaagatg 98820aacctgttaa tggcacactc aaaggacaca agagagctga ggtgagggag accagaaaca 98880ggatgaccac ccgctcagag ccaggcatgg gggtgtcagc tgtgcagcgt ttcacacaca 98940tctacatgca cacacgtgca ccagagcaag cacaacgtgc atgtgtctca cctagcctgt 99000ctcctgttag gttaatacaa ccgctttcaa cggccgcctc ctttcacggt aaagcgagaa 99060ctgtggtctg ggtgtgctca gcgggcacag gcctgtggtt ttgctcccca gtgccctgcc 99120tctcacagac ctgcttgctt agacatcccc ccaccccagg aggctgaggc tgattccagg 99180tgaccctttg ggatgcttgg aagcgctcgc ggtgatttaa acagaattaa ccagcagaaa 99240caatcctttg cggaggtgca aaagggcagc gaggaaaagg ctggagcaca cctcagattg 99300gacccagatg actaggacct gccagccgca gcagagggat tgggatacaa cagagaccta 99360agaagcatca gtactaagaa tttatggtgg aaaaaaggga tctgttttga aaccctaagt 99420atcattttta ttcatttgtt agagaaagaa ggtctaagac agaagccatc tgcctgaact 99480gatgtctcaa ataccttttt ccaattgagc tggtggtaga atctttgcca cacatactat 99540taaaggcccc aggcataggg ctaaatgatt aacacgtgca agggctcagg agggctctct 99600gtagttcaca cacagctttc agacaccaaa caccaagagc tggtgcccct ggttgaaacc 99660accacggcaa cacgatacct accacccacc tgacagccac ccactcatca gtgacactcc 99720cctaccccag gaagaagaaa gctggaaaac actccagaga ttcaaaccta ggaatgagag 99780taaacttttg cctttatatt catttacttt caaagtaact gaagttatcc ctcaccctga 99840aaatcagcct ggttcatcct gaccagggga aaaaaacaca ccaacaattt tctaacacta 99900atcatctgac atcctcaacc tttaaatatg atcaaacttc aggcttcctg aagatgagat 99960tccagcaaaa atttatttgt tgtattatct gtgttcattt tagtagaagc aaagaattat 100020taattttatg gctgttctac cctgaatatt cactaagaag gaagagattt tctgaattca 100080tcagctgtaa tggcaaaacc aaaaagaaaa caataagact cacgtgttgc tcatgaacac 100140aatgacagaa caccacacac cagttctgct gctacaggta atctatataa aaaatgtaaa 100200cttactgata ctcattgaat ttgtcacatc gctcattaca cactgtacta ctctgtccct 100260tagacgttgc tttgtgagga aatccatcca cagacgtatc cacgtagagt tatttgagca 100320aataaaacca acaaacaaaa acacttttag cagagatgag agttgttcca tgtgacatgt 100380cgtgcagtgt atccactccg catctccttt ctgctgtcgc ttgtgacaga tgacattcat 100440acgtgggata cagtcccctg tgccactcac cataatgccc tgcagatggg caataattcc 100500tccccttttc tcctccactt acaagagcaa tcagaatgca aatgaaggag agagctgtca 100560gtaaaagctc caccttcaaa ctgctcaact tgactccccc gaaagagaga aaggaggaaa 100620gaaaacaaat cactagaaaa cattgtgatt aagacaagga ggaaagcttc cttgtaatat 100680atggaacaat gtcccaacaa tgacatgtca cacggagctg ggcaccatga ctgcaatcac 100740attacagaaa actgaagtgg gcatcaagcc tagaacatgt tggaaataag gtcaatttgc 100800tccagccaat aaaatcaggc agcattttcg gcacacagtc tgactcacca atcctttttc 100860ttcataattt ctcctgacaa tttgggtttg gacatgtttg cctccaatgt tacatttcga 100920tgttcaaaat ccaggatata cacctgggtc gtggcagctc tgcccaggga ggccccggtc 100980ctctctgcag aggggcttac ggccaccacg tagggcccca tggcacggct gtgggacatg 101040gggcctcaca ggcctttggt gagcaacact ggaccaccca gaggccaaat tcatggagta 101100ggtaaagatg ctttcacatt ttcagccata gctgaattag gagtgttaca aatactgatg 101160tacttgacaa aatgaaacga tacacttctt aaaattaaaa tttgtatttc tagtagcaaa 101220tgtgattccg aaagcaagga aaccttccat gagctcaaac atatcgtaca ggtacatctc 101280agtgcccagt ttcagccttt tatgttaaac acagaattac aagggaaaat tgacttttca 101340gttgcaggag caattctgag aaaaataaac ccgataattt agtatctcca gactttacta 101400aagcaagaca ctctaagaac atgaaaaaaa aaaaaaggta aggttgggta tgataacaaa 101460agccagagat tctaggaaaa acggttactt gaacttttct tttaaattgg aaaaaaaact 101520aacttaaaag gaaaatatgg aagaataagt tccccatgac aaacaggggc aataacttgc 101580tttcctgctg ccctccttga gaaagactga aaacattctt ttctatgagc tcatcacttc 101640cactgacaat taaaatcatt tcattttgaa tgcttgttag taaaaaaaat tccgaatatc 101700aagttgcaac ttgatgttaa tgacacaata caaaatagga tgagacaatc tagttgtctc 101760acaggctgga tttagtaaaa ggtatctccc cctttaactc ctgtttaatc ctgcacataa 101820gacctggtct taatcatcca aaactaggaa aatcaggcct cctaaacttt tacctactgc 101880acttccaatt ccctctacac attcaacttt cctatacagg agcctgtata aattttacag 101940tgcacggcta cagcagattg tgtaacacag aatgtacacg gttcttttct gagtgttatt 102000gttaaaaacc ctgccatgtg catgaagtga gctattcgtc tatggcaaga attgcccact 102060gcccctgcag cagccgccaa tgccatagga gaaacagtat cgatgattct tctgcacaaa 102120cacctgagat acaaaaagtt ccaagaattg cgggtggacc ctttctttta aattatgaaa 102180tgttagaccc tttttagtta aaacccagac caggaagcac gaacaacttg ctgaagcctc 102240cctgccagtc tgtggaagaa cagggtcctc aacttctccc agaacacttt cctctctgct 102300cccctttggt gacaatgaga tgggtgggac agggcaggag cagagacacc tgcaactgtc 102360acctggggcc ccagagtgtc aacttccaca gtgaaccact agctctttat aaaactctcc 102420tcgaaggaca ttaaacagca tgctagcatg tcacaagatt cagtgaagcc tgtgagtcga 102480tgagggtgtg ctccatggtt ggtcttcctt gccagctgat gcccaggccc tgccttctca 102540cctccctgtc cccagcagcc agcagcctgc tggtcaggtc cttagtaaag cttataggta 102600ttaaattgaa gcgaaaaccc catgtggttc atgccatttc tcacaggcag aaatgctcaa 102660taaagttttc taaaagagaa caaagttttc taaaacagaa cgaagcttta ggactgcgtg 102720agacccagaa gaaaagaaaa ccctttccag cccacttgga gagtgacgtt ccaagcagag 102780gtcagtaaag taaggccaga tctggcttgc ctgtctctgc aaataaagtt ttatttgggc 102840acagccgtgc tcacgcattt acatatggct gctttcacac cataagcaga gtggagcagc 102900tgtgacagag actgcatggc aatgaaccta aactctttac tacctgacct ttcacagaat 102960gtttgttaat ccttcaagga gcacatgaac atggcaacct ttactaagga agacaatgcg 103020aagaaaaaca ggcaaatttg tcagaaaaac accatatatt tccatctgtg tgttatactg 103080ggaaactaat tgatatccct ttgaaaatta tctgcaagct tacgtacttt agaaatgcaa 103140tactatctac taaaaaccac actatcctgt tacagaccct actgaaaaag aggacacaca 103200tcacaaaatc atttatgaag ccagcacact tttggaatga atttctctta gctaccgcta 103260ttctatttga tttttcatgc ataacacaaa agtgctcaat aaatctaatc attgctaaat 103320acatcctaca ctagcattct tcctttaaca gaagtaaagg tttatatatg agatctacaa 103380ctcattaagg gtccaaatct tttctctttc ttgggtcatt tgagaatgtg aatgtaagca 103440ttatgcttct gccctaagag tatttgggcc aagtgatata aggtgcatta aaatcgcaaa 103500tagccaatga acgacgtaat tctttcctca gacttaacac atgtttatac gtatggtttt 103560cttactaatc taaaaaaatt ttatgtacac cataacaatg tttatattgt ttatatcaga 103620aattataaaa cctaattata tttttgctgc caaattaaga gaatgtagaa

taattattta 103680ttcacaatat atccatctcc agatagcctg ttgttatata tcatttcaac tggacctttt 103740ttctacttta aaagcttaaa taactgtagg taaatccccc ctcctcggtc tataacatct 103800atgtgatata ggatttcagc tttgtctctc cagggacaaa tccatctatc taatttaaaa 103860gcctcctaag aatcaccacg tagcctttaa ctgagccatc tactagagtc aaggttgaag 103920ggtcaaatcc tacttagtca ctgaagcgca ggctctcttt gcagagatca aagtgcccat 103980tcttcctaat cggccatatc aaaaacatcc tgctcttccc tgggagccta ggaatgactc 104040catgccccca tctctgtact ttaaactaca tgccattccc acgactctca ggatacaggt 104100gtgaaaggcg ctgtcgccac accagagccg ggtccccagg gctagcatct aggaaccact 104160tcttaccagc tgtgtaatct ctacagctat gtctctaagt ctgctccctc ttatgaagat 104220gggggcacta cctctcccac cctgaattcc ccagtggagt cacagggaac ctgtcaaatg 104280agatttcatg tataaaatat ataaataatt aataccaaaa atgcgtatgt tctttcattc 104340ataaagaagc acatgctact agcacaactg gcattttgtg gttggcttcc ctttgctttg 104400tgcaccttca aataatgtat acatgtaacc acatgctgtg ttctcaacta cagacttctt 104460aagaccaggc agccctgtgc tgccagggaa agacaggctc ctcccaccct tatgttctgg 104520ctaatttgtg gagagccaca gtggtgtctc ttagtgcatt tgtcatcaca gctcttcctc 104580gttcaaaatt gtattcgtga atgataccac gaacaaccac aactgcaagc agcaaataaa 104640caactgccga atgcacaaaa acaatggcaa attgctccta aaataaaatg aacaaacttg 104700ttttaattgg acagaagtgg aacagaagta gaattgtttt tctgggggta actctaggcc 104760atttaaagct gcaaagagtg cctttgccta gctgctttct tcatgtcctg aggacaggac 104820aaaatgcccg ggaaggggcc tcacatgtct actactcagg cagctgccca cagagaacat 104880gaatcccttg ccacgtcaca catgccaagc acacacaatg catcatcaac aggctgggct 104940ccgcctggtc caggccactg ggggacagca cttcccttct ctctgctcta tacaaaaagg 105000tgccctaaaa tgcaggccga catttaagtt cctctgccac aaatgacaga gatttacatc 105060taactaaagc actatttatt gaaatttcag taatgcaaaa tggaaaacgc caagctacca 105120actatataaa gttcatttac tggagaagca aataaaataa gacagcagca gctgatcacc 105180agtccttgcc caaggatgtg gagacagagg aaatccacat ctttggctcc tcttccccaa 105240caagcatgta gatatcccag cctcaaccac cctgactcca actccccacc aagcatgtag 105300atatcccagc ctcatccacc ctgactccaa ctccccacca agcatgtaga tatcccagcc 105360tcaaccaccc tgactccaac tccccaccaa gcatgtagat atcccagcct catccacctt 105420ggatccaact ccccaccaag catgtagata tcccagcctc atccaccctg actccaactc 105480cccaccaagc atgtagatat cccagcctcc tccaccttgg ctccaactcc ccaccaagca 105540tgtagatatc ccagcctcat ccactttggc tcctcctccc caccaagcat gtagatatcc 105600cagcctcaac caccctgact ccgactcccc accaagcatg tagatatccc agcctcatcc 105660accctgactc caactcccca ccaagcatgt agatatccca gcctcatcca ccttggctcc 105720aactccccac caagcatgta gatatcccag cctcatccac cttggctcct cctccccacc 105780aagcatgtag atatcccagc ctcatccacc ctggctccga ctccccacca agcatgtaga 105840tatcccagcc tcatccaccc tggctccgac tccccaccaa gcatgtagat atcccagcct 105900catccaccct gactccaact ccccaccaag catgtagata tcccagcctc atccaccttg 105960gctccgactc cccaccaagc atgtagatat cccagcctca accaccctga ctccgactcc 106020ccaccaagca tgtagatatc ccagcctcat ccaccctgac tccaactccc caccaaacat 106080gtagatatcc cagcctcatc caccctggct ccgactcccc accaagcatg tagatatccc 106140agcctcatcc accctgactc caactcccca ccaagcatgt agatatccca gcctcaacca 106200ccctgactcc gactccccac caagcatgta gatatcccag cctcaaccac cctgactccg 106260actccccacc aagcatgtag atatcccagc ctcatccacc ctggctccga ctccccacca 106320agcatgtaga tatcccagcc tcatccaccc tgactccgac tccccaccaa gcatgtagat 106380atcccagcct catccacctt ggctccaact ccccaccaag catgtagata tcccagcctc 106440atccaccctg gctccgactc cccaccaagc atgtagatat cccagcctca tccaccctga 106500ctccaactcc ccaccaaaca tgtagatatc ccagcctcat ccaccctggc tccgactccc 106560caccaagcat gtagatatcc cagcctcatc caccctgact ccaactcccc accaagcatg 106620tagatatccc agcctcatcc accttggctc tgactcccct gcatgtgacc cactggcact 106680gaaacagtgc acaagtcata ttcagttact gcacatgccc tttcagccaa aatgccaaag 106740tgtctataaa gttactcaaa aacttaagtc taagcagagg aaacatacat tctttagcct 106800cggtagaacc taaaatggca aagatcttgt agacattttc caatgctcat gggctgggag 106860gagcctcaca caccagagga cccagatctg cgaaatgctt tggtcaggga catggaggga 106920ggtttggatg agtgggcagc ctagaaacgt gggccccaac ttctcctgga gggtccagca 106980gggtgccctg agtcaccagc agttggattc agagtgagga caggcccctt gctcctgcct 107040ctcaggccca gggacagagg ccagaggctg tgcaggtcag tgtgcaccct ggctcctgtc 107100caggcgggcc acaccgggaa tgtggccaca aacacgtctt ctgccctccc ctcctgtcca 107160gcaaggagaa ggaggtgtgg aaggagaaaa tacccagcaa cataaagatt ccatttccca 107220aattgccaga agtttggaaa ggggagaact gatcaattaa tgataaagaa aacatttcct 107280acacgaaaag gaagttggac tgtgtggtga ttgacacagt cacatttcct ggtttcccaa 107340ggctgtgcct gagtccttga aggcctttaa gaatggattc aagagagatg taactttcta 107400accaccttgt tagtaaccaa ggtgacaaaa ctgaggatca agcagatgcg tacagaatag 107460acagtagttc tgtcctgtgt gttacagact taatgccttc tcttcccaga gagcatcacg 107520cagtgatatt ccattctgga aaatcagctc gaccattttt cctttttttt tttttttttt 107580ttttgagatg gagtctcgct ctgttgccca ggctggagcg cagtggtgca atctcggctc 107640gctgcaacct ccgcttcacg ggttccagcg attctcctgc ctcagcctcc taagcagctg 107700ggactacagg catgcgccac cacacctagc taatttttct atttttagta gagatagggt 107760ttcatcatat tggccaggat ggtctcaaac tcctgatctt gtaatccacc agccttggtc 107820tcccaaagtg ctgggatcac aggcgtgagc caccgtgcct ggcccagtgt gaccatttaa 107880acatttctag ttacatgatt ttgtaatatt caatatatat gaaatttcta gaaaataatt 107940gttatttccc tcattttgct tagagaatga tggaccattt tacaaattct acttggaata 108000actagcaaca cagttcaagc agataattca agaattaggt cctctttcac cattagtttt 108060ctacatattt caggaaaact aagtcaaatg gagcctaaat tctgaagata gacctaaatg 108120ctcaaccaca tttttaaaat tatgcaggct acaaataact gcacacagtt ggctggagcc 108180catttattaa acatgcactt tcctcaccag caggctaaga ggacatcagg gcacccgtac 108240acacctagcc ctcaccttcc ccaagctctt acgccctcag caaaacccat gcccttggct 108300ctttcctgtg aagccaggat ctctatgaaa caaatggaat aatacattgg aataatactt 108360tttctgcaca ttttttctaa cttctataat tttcatttcc aaattagctg aagagtgaaa 108420ttgatttgtt tgataagccg atggttagca ggtcctagtt aaccataatg cacggggcat 108480cccgcctcaa ggcagagttc gaaataagcg gattcagctt ttagtctgtc agagggaaag 108540accttgtctt ttttttttta aatgacggct gtgtgttacc agaagataca gaatcaggca 108600ggagccaggc ttgccaggac cacatcctct ctctacagac tgggaaagtt tctccaacag 108660caggagccag gctcaacggc ggggcaggca tatacatggc ctaccatctt caggcctcag 108720attttccatt aaaaaacagg gataacaaca agatccaacc ctacgcatag gttattggga 108780ttcaatacca tttttaaatg tcttatgaat tataaggtac gctacaaacg ttaagttttc 108840agaataaggc atgtcattcc atgattacaa acttgtgctt ttgttttgca gtttatcctg 108900taagcacgtc ccagtagttt ccccaacctc aatggtacct cagcgtcttc attccactag 108960atcacttcta ggtcttttca aattttatat acttttgagg aagaaattcg agttgacgta 109020tactctacca agtaaccacc accacccagg gataccacca ccatgatgat ggaattgatg 109080gctacagtat gaaagttttt aaaagctctg catattattg ttcccaagga ctctatctcc 109140ctcacacact gtgacatgtg ggctaacatc agtagcacgg ctggccgggc tcaattcctc 109200ctggtccctt actacctctt tctcttcact ttctcctttg agccttagct ctccatgcca 109260gccacactgg cctccttcct gttctggaac ataccgggca acctgctgcc ccagagcctt 109320tgcactgctg ttcatcccct ttgcctactt ggattcctcc cttaacatct gtaagaccgg 109380cttcccctga ccttcaggtt gcttggctca aatttccttt cccccctctc ccttccctgc 109440ttcattgcta gagcatttca ccacctgtag tgcttcatct cctaaatgca catccaaatt 109500aagtttactt cctaggtttc aaaggcagac agctcactga agactcgccc actttctgtt 109560attcttttta gcttgaaaaa ccaaatctgt ttctctctag cctattcttt catattgctc 109620aaatggatga agtatttttg agatagtcta tatgcaacaa ttgtcatctt tgtaatgaaa 109680acatgcagaa atttaacagt ttgaatacat ttaaaaatta aagggagatc tcaccatttt 109740tgccatcgtc ctttctgccc ccaactttct acctttctca agcaacccat aagtaaagtt 109800cctatttttc tttttttctg aaaactgcaa aaggtggcaa aaggtgagaa tgggaggaga 109860ctcatctgtg actaactccc ccatcagcct cacgggtggg tgacttggag ctccccaacc 109920caatgggact tccttctttc gcctacactg gccaccacca tggagggcag ggaggccaag 109980agcggcaagc agccctttga gccggtgggg gctgtggctg gcaggaaagg agggggcttt 110040cctgaacagg ctagggatgc ctatagaaag aatgtgatca atacccttaa cgcagccttt 110100ggggctgcct acaaaaagga gccaagaaac ctgacaatgg ggaagtttct ggaatactac 110160catttacaac aaagactgag cacagaatga agtaccagga gagcttggag gcaaggccgc 110220caagagctca gggcaagctg acatctagga atcgggatag cagcagaatc aaagctacta 110280tttttcagag aagaaaactt acaaacacta cctcatctga tgcaccccag gttcacgcag 110340gggtgaaggg gtgaaacatc tgagtggtcc cagctgtgaa tgggaccagt actgtgaatg 110400ttccagcaag gatatccact gtcgcagcag agacatcccg tgaaacatcc cattctctgt 110460gctcagccaa gattgcctgc ggggtggaca cttatgaaaa ggatcagagg ggctgcccag 110520aaaatggtgc ccggtgggat gctgccaagt tgactctgaa ggcacctagg gaacagaggc 110580caggcttcac atttcttctg catctcccag gacatctact cttgtgctga cacacgctga 110640actctcaata cattgattgg cttaaaatat caactgtgtt ctgcgttttg gaaatggctg 110700aagacccagt gattctaaac agcccagcga acctggacag atcaagactc acacagatga 110760atgtgtatca cccagacttg ttctaagaac ttcattaaat gctccctgct gggaaaactt 110820ggacatttca ttgcagtgat tatttcatct cgaactagga acactgataa gctaagctgc 110880aaataacagt aagacggcaa actgaaccaa ggtgtgtcct ttctactgga ccactgaaac 110940tttcatctgt ccccaaacac caaaatgccc ttacatgtag aagctacaaa acctttagga 111000gaaattctca tttaaaaaac ttgtcagaac aaataatctc aacaatgtct ttgcatcaat 111060gaatgcaaat tcatggatgt ttatatctaa aagggttttg tgtagccttt gtatctagta 111120ttttcatgca gttcaatatt aatatttaat ttttttctct tttgctttct cagccagcta 111180aattaaagtt agttttctga aactgcaatt aaaataaatt tacaatcctg gatttataat 111240actttaaaag agaaaaagag atttggtact tttgcaacta acacattttg ctaaagcata 111300ctcaaatata ctttcagttg aactatacat ttagtagatg tctacttgac aacataagtt 111360atttgtacaa gtctcagcac actcacctga tatatagaac tggaagaggg tatgggtagc 111420ttatggattt gttttctgtt tcatttgcgt atgtaaaacg ttattttagg ttgcttttat 111480gcaggaagac aataaaaagt gaatacctac tatcatacca gaataaaact gaagcaaagc 111540actttagtaa tttatttttt taaaatgcac caaaggtgtg gggtaagaaa ctgaccacaa 111600gactctactt ttccaggaat ttctgctgtc tgggaagttc agaagccctg caatgtccac 111660agtaaactag ggtcccagta cctccatttc tgacctcttc aaacagaaac agtctctgct 111720caatacactc taatccacga cttgcttaat cctgcttatt gcgtggagtt tctaaaggat 111780tatgtgcatg gtttttaaat ttagtaaaga aattctggcc tatttccaaa acttttctcc 111840ctgcttcaca attcccctta tttatccatc catctgggta tgggaagtcc cgaacaaaga 111900aaggagggca gagaggctca cccggcatgc gctgggccca ggcagcgcag ggcagtcatg 111960ggtgagggtg gccactgaga tgacgggatc gggggcggct tctgccgcag acccgggaat 112020tcacgtggtc agatggtccc tgacttcagt ccctattttc ggtggttcat agcacggagc 112080ggtgcaggta ggtgcacgct cttcccaggt cctctgcaga aggcaaaagt tcccagaggc 112140acccaaacct tgctggggaa aaggcttctg gccgattcat gaagaccccc agaccacacg 112200tctgcatcag ttttcctgac taaattggtg ggtgctcaac aaacccatca ctgcaacaca 112260gggcgctccg aacgtggctt tcttcttaac ctggaagaag gtccgtaact ccattcgccc 112320ggatagcaaa actgctttcc tgctttgctc atccagccag gtctccaatc tcacctgctg 112380tttggtgggt cacggcgctc accgttgggg gtgctggcca ggaaggaggt actgtctctt 112440gatgctgaga ggcctgacag cttgcacaaa gcaaacactg cactgcccac aagagttcca 112500ggccacagat ttgcctatta catttttttt tttttttttt gagacggagt ctcgctctgt 112560cggccaggcc ggactgcgga ctgcagtggc gcgatctcgg ctcactgcaa gctccgcttc 112620ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 112680caccgcaccc ggctaatttt ttgtattttt agtagagacg gggtttcacc ttgttagcca 112740ggatggtctc gatctcctga cctcatgatc cacccgcctc ggcctcccaa agtgctggga 112800ttacaggcgt gagccaccgc gcccggccgc ctattacatt ttttaaagtg tgaatatctt 112860aagaattttt atgtgtttgc taaagtgttt ctttctgctt ttgaaagtga ggttataccc 112920acgtcattag aataatggca gcttctgtga aattaaattt gtatgaaaac tatttatctt 112980catataaaaa tccagctaaa tgattttttt cctgagaatt aaaaaaaaag aaaaaaacaa 113040gggctgttaa aaataaaaag gcactgacaa aatactcaat tccccagaag ataaccacct 113100agcaacaact gattagttag ttattggtcc ttaggcaaat tctaaattga ttagttttca 113160aataaactca ttaaataggt taatgactca tttcttagaa aaatgttaat ggacttatcc 113220ataatgggga atatatgata tttcacttat agaacaagca cctgtcttag agacacagag 113280agcagtgacc gaatgcaccc gctgactcat cactgtgtca ccgcccaggc tgaacctgtt 113340acacagagcc gccttcaatt ctgctagata atctaggcct ttcgatttca ctgggggtct 113400tcatgaaaca ataactttgt ttccttttct ttgataaagt aaatacatga ccttaaatat 113460ttgccaaatc ttctccccac tcagtagaca ccgtccacat agtcatgaac agccatattt 113520ctctgattta taacgcgttt cttcattaag gaattctgca ttctctattt ctggctttca 113580gggtttcttt tagtctatgg atgaagaaag ttactaaaat gttccaaagt aaaaagacta 113640atatcatttc cacaaatact aagttgttct aaagagcata ggctgtatcc tgggagaaag 113700ttattcatca agatacaaag aaccaactga gatgtgtcat tgtttgtatc acattctcct 113760actctttctt gatgatatct acaaacaact ctaccactaa ttgaatcagt gaccttgact 113820aagactccgg acctcacaca gcctctgttt tcacaacctt aaataactaa gttacattct 113880atcaacggtt ctcaactctt ccttctcaga acacccttgt atattttttt cgtattgtca 113940ccacctgagt tgcaagagtt ttaatgtatt tgatggtggc ggtggtgggg aggtatctta 114000ccaagtatca tatacagttt gctttaccaa gaggtaatga aagacagcca gagcaatcta 114060agttttccac tttgttgaca catctagagg tccaggaagc atgactggag tccccagaac 114120agatccatca ccaacttgat ggtcaacttt aaaattcact agtaacatca cagccttgaa 114180aatagtatca aatactaaac tctccaaacc ggaggatgta aaaactgatt tcaataaata 114240gagcgctttc ctaccagtct tcctcctcaa tggtccccat tttcctttga attgataccc 114300agtggaagaa aaagggggag atgattaact atcactccag caaaatatta acttaaatgt 114360tgcttgaggc aagggtctag gataaaatcc taatgtaatt attgcatatg agcttcccaa 114420gcagacaata tgacattaga gaactgggct agggatacca agatgttatg aggttgaacc 114480cgacactcct tctccttttg gctcagagat ctggagcaag tcatctggcc tctccacact 114540gtaggttctt gattccaaag aatggggttc atggtggttc tgcctatgcc ataggatttt 114600ttggaatatt ataccatatt gtatatagga aaatgtctta ccactataaa gggaagaaaa 114660acaccctttg aattttacac aactctttta accccaagag aagagtggca ggcagttatc 114720cgtcaatatt gatcagaata atggtacatc gtcattgcat tcaacttcaa taagattctt 114780tcaaaatctt cagttgccag ttgtctacca agttgtggga ttatctgtta cacttatact 114840ttggaggcca aagattgact tatttaagtc catagaatgc atacagaaag cactgtatca 114900tattcttaaa tattaaagat taagcattaa tactatgcaa aatctttctt tttttttttt 114960ttttttttga gactgaattt cactctttgt tgctcaggct ggagtacagt gtcgcgatct 115020cagctcactg caacctctgc ctccctggtt caagtgattc tcctgcctca gcctcctgag 115080tagctgggac tacaggtgca tgctaccatg gctggctaat ttttgtattt ttagtagaga 115140tggggtttct ccatgttggc caggctggtc ttgaactcct gacctcagat gatccaccca 115200cctcggcctc ccaaagcgct gggattacag gcatgagcca ccaagctcat ccaagaatga 115260atcattctta acataaacat aaggatttta aggtaacaaa atcacacagt ataataggat 115320tgtaaagtaa caaaatcaca tagtataatg aactatatca taatatctgt ttttatgcat 115380tgaaaacaat tgaaatttca taccacaccg taataactga ctcaagtatt tgtactaact 115440gtatagggat aaagtagcag tagactatgc ttaagttata aagtttcaac atgaacaaag 115500aacacatcat taatccttga atttcagtta tggagaaaaa tatcatatcc agcctcctgg 115560agcatgactg gatgagatat tatggaaaca cacacacaca cacacacaca cacacacaca 115620cacacacaca caccagcccc aaatatttgt tgctggaaaa cctgatactc tttaaaatga 115680atattaaaag atccagcatt aggccgggcg cagtggctta tgcctgcaat cccagcactt 115740tgagaggctg aggcgggaag atcacggggt caggagatcg agaccagcct ggctaacacg 115800gtgaaatccc atctctacta aaaatacaaa aaattagcag ggcatggtgg catgcacctc 115860tagtcccagc tactcaggag gcggaggcag gagaatcgct tgaacccggg aggtggacgt 115920tgcagtgagc cgagatcaca ccactgcact ccagactgag tgatagagtg agactccgtc 115980tcaaaaaaaa aaaaagaaaa aaacccagca tttacagggt gcaatgcgtg tgatcagtta 116040tctttaaaaa atatatcgtg ggtcaaaata tttgatcaaa tattccaaat ttcagtaaaa 116100acacagtaag caaggaatat tttataaacc ttgtgtatat agatatcata tatgacataa 116160gaaaactgga cagagtttcc aaggcttcac ctttacccat tcaagtttta cagtgtcttt 116220ggacacataa aagtgactct atacaaactt agtattttcc tagtctaata gaaaattaat 116280cagaaccacc aaattgacta ttttatcatt tgtaaacatg taacccataa gttttaatcc 116340aatctatttc agaattctta tgtaatgaat tcacttaagt aataaagcta taacacacag 116400aagcatcttg cattatttgc acctacagag caaaatgttg gtatacaaca tatactccaa 116460ctctttctac actaaccttc acctatgcat tgtattttag cacccagtta atgtaagtct 116520ctgtagctat cttgaaagaa attgaaatca gtagcaatca tcaaccccat catctcctcc 116580atgccaaatg atgactttac tagttttctt cagaaaagtc tagcactgaa ctctgtgtac 116640aataatctac ctgaaatgag tcagaataac cactgcagtc ttgaagaacc cactcaaact 116700aaatatagaa agagtgtccc tatctaaact tggacagcat tcttttcaca aaaatcatga 116760tctgacagtt aatgtgttta taaccaatac ttttggacat tcagaaaatt ttgttttcat 116820ttgttcatta aaacgccaac attaaaacgt tttgttcatc ttgtatagaa atatacattc 116880tgctgtcatc cgtactagag aaatgaaaca gagaatccac ctgcattaca gctgtccaaa 116940tgcaggatgg ggggcggggg gcacagcact ttgcctcacc cagtgttttc ctcattctac 117000ttggcaatgc agatgaaaga ataaagttac attttccctt aagtttataa ggtgaaatgg 117060gaacacttga ttctgtgcta ctccccctag aaaaaaacca aaacaaacaa acaaaaaccc 117120tttctacttg ccaaatctga taccaaaatt agctcttaga actacgtttc taaagaaaat 117180gcattagtgg gaattttaac agaaaaccca ttatactcat gctgttacta aaacttttcc 117240aagttcttct cttcagaaaa aagagcctca ttttaaatac tcatacttct aaagaaaata 117300aaatatcaat tctctactaa gattcctttt tgggtggtag aaaaacaaaa gaatcacgca 117360ttttcctact atgtttgata agcacagtgc taccatcaaa actgcaggaa tgaccaccct 117420cattaaatcg accccaaaga atgaaccccc agactaaaca atgagtagtc aaacaacctc 117480agggttctgt ttttctttca atgcattcgg cattaagagg cgatttttaa aatgtatatt 117540ctaattatac attttcatct tgtcaacatc tcttaatata aaaaccagta ataaaaggta 117600atcagaagtt cagtcttaac atagtttcag gattaccata ctgttttccc taattgttac 117660tttactatgt aatttagaac accactttgt tacaatctgt tcataaatat ctatgaacag 117720atcttaagtt acataaaggg ggaaaacaat ggctcttggg agcctggagc ggaactagca 117780ataagcagta aaggtaagca atttttaagg tgctggctcc attttcagac tatgctgtta 117840ctgtttgttt caatttaaga gcacccattt acaaaagtgt ctttcctgta tacattcatg 117900gtttcaaagc aataagtatc aacaactgga tttattagca tcttccttta gaagagctta 117960aaacactctt gatgtttatg acctcattta ccttccagcg gccttgtgac acagaaaggg 118020gaggattata attaccccca ttttacagac agggaaagtg agaaggcagg attaagtggc 118080tctcccatag acacacaatg actcattaag atcagcaact agaaacctgg tttcctgatt 118140cctggtttag tgttccacat actatgcttc cttctatgaa gtactatttt tgtaaaggtt 118200tctctttcaa taaaggaaac agaacaagtc atgtgacttt cattcacgaa agccggtgtg 118260tgttttcatt agcaccttag ttgtctgctc ctgcgaatag ggcagcagca gtgcacgcta 118320ttgtcttatt atggccagag ccagccaact aaagcaaact agcacccgcc acagcaaaca 118380gaaaacttgt gtggtttgtc aatcacctca ctggatttct gaatttagga aaattctctg 118440ctttacgact tcaaaaggca aaacttttca acataaatcg tgattttatt gtccctttgg 118500aaacatatct cttatcattc tttcccctta agaaatgata atccttttat tcaacaaaat 118560ttaaatatgg atactttcag tagtaattct gatctaatct gtcttataca tacatacata 118620tatatacgcc aattttagaa taaaatccct aaaatcacta aaaaggaata ctaaaacagc 118680aaattttatg gcattcatca atctaccatc ctaacacaaa aacatataaa

gttaatttta 118740aaaatcagtt ttaaagcaca ggaaattcag tagcgtcttt ccaattccca aacaacaacg 118800aaacctaaca aattggttag agttttccac atgcacacac accaaaaaca catgataagt 118860aaccttaacc tgccctcaaa taagatgcat aattttgagt ttgctctgga ctaataaaaa 118920cagatgtacc tgagatatac tttttaactg gctcttgcac tgaaagccca cccccattca 118980cgattctatt gtaaacaagt gccagacatg gctggaacct tacctctctg ctatcactta 119040tgcaaatacc aaacattacc cacataaccc caaaattatt ctgcatcagc atcactaacg 119100aggtcttccc atgcagaaca ggaagagctc agggtggaaa cacaggccac ttctaagagc 119160caggcagggc agggggccgc ccaggaagtg ctttctctat ttcatcttca aagaaatgct 119220ttgcaagtcg gccttctaca aatcatttcc tcaaaggaca ctgatctact gtgaactctg 119280tatttatgag catcccaaac aaatttctag tgcatgtatg agttaaataa aagtgggtat 119340ttatcccaag ttcctaaatg cttcctttct gtctcaacgg accacaactt tggtgctacg 119400tggactaagg tgacactagc ctttcctatt ctgctgttct ctgtgttcaa cttactttac 119460tagaaaccca atggggcaga tatttctttt tttttaaatg tcgttgggca tggtggactg 119520actgcagttg tctattttga tttaaaagat ccttttactt cttagaagag ggttcatcat 119580gatacccaca caaacttcgg acaaacagca gccccagtga tctctcatct ttgttcagca 119640gctacagaac acaggcttct gtctggactt cagaatcaag aatcctatgg gctgaaagga 119700attttacgca ggtgggaaat cttaaacaaa agctcaatcc agtctctaaa taaacttatc 119760tcttagagtt caacattttc actagcctga aaagggcatt atttcctatt tggaccccaa 119820ttctgaatgt atcggcttca tcagaaacgc cttgcgtccc tccaggcctg gaggcacaaa 119880ttccagctta tggcgcctgc tatggcagag cccactgctg gggccccagc tccacccagt 119940ccaggtttgt cccaccagct ccactgaaag caggaaaagg tgttatgttc ttggctgttt 120000tctgattaga atcagattcg ggtaagatgt aatttacttt catgttcact ctggcatata 120060cccatttgtg cagaccataa atatgtgtgt ttttccccac tcaattatac tgctgctgct 120120gctgctgtgt ttataatggt ctgtgtctta taaggcagct aatccttcaa ctttctgaca 120180cactagcaat agtgtataag taactccaac caaagtgacc ttcagctgag aatcactgtt 120240cacaggatac attctggcga cttccaatga tttaattgga tgctgaagca ccacactcct 120300gataattctc tgtgactctt catcttctag tatacggttt taataaagga aatagctttt 120360ctctattaca ctagaataac agggagttca ccccacagct ataattttaa atcccatgga 120420ccgacagtcc taagtatact ataaaacaga tgctggattt agatagcact aaactggtct 120480atttaagaac aaaaggctgt gaatctccag cccaccttga tcctcatctc atgacccttg 120540aagactgttt acaccttagg ctcacatcta atccagcatc caaattttac tatatgtttc 120600actgttccca caaagcctct atcctgctag gaaccctaca aagaaaacag ctacaaaatt 120660aaataaagtc tcccgaattg agcattcacc tttccctctc atctccccga ccccaaacac 120720cattcaaagt ttagacagcc agaatgcacc accagctgca ttctgcatca gctctctctc 120780ctcatggata tttgatcaga acgggaagaa caataccagg caccctccta tccaattgtt 120840cttgagaaga cctgtgtttt ttgtctttcc cttgttttct ccaaagcact gattgtaaat 120900cctggctgca cattcaaatc acctggacaa ctctgaaaaa tgtccgtccc tgcctcctag 120960ccatctcatg tttcacttca acgggtctgg ggtgaggccc aacaggtaat ttttcaatcc 121020tccccaggtg agtctcacct ggggcagggt cctcacaggg tggtcccccg gccagcagca 121080tcggcattat gcggagactc actagaaatg cacagcctgg gccgcgcccc aaagctacag 121140catcggaaac tgcggggtta acacaggcca gagatccatg tttcagcaaa gcctccaggt 121200aactcccaca tatgctcaag ttgaacacca ctgcattagg ctgtgtgcag ccttaccgtt 121260tcaccccttc cgagaaaaac aatgcctctg atggaaaagc tcccacagtt tgtgtgtaaa 121320acggaaatgg ttaactgtcg ctattagcag ccatcaaaat ggatgctcat ttcttaaatg 121380actttcaggt ctgaaccttc aagctcacca agaatcaggc ggagcccagc tccaggaaca 121440cagggaaagg tgaaagctgc ggctgagggc agcggtccgg acccgaggtc cttccagaag 121500gacggaccca cgcagccgga tgaagacagt cgggtgcccc gcggcctcta gtgtggccgg 121560tctgggagaa cttccactgt gttaagggac agggggctgt gggacgcaca gaatgggtga 121620atgggtgggg cctcaaaaaa tcagtctccc tcccacgcgg aaaacgtcac attcaactcc 121680aagacgaatg ttcctggcaa gttctctgaa ggaagagaac agggcagccc gcagaaaaac 121740aaaacaagga gccagtgcca ggctgtcggc ttctgggtca aggtccccaa aaagtgggag 121800cagtgaaacc caagaggctc cctcagcgcc ccgcccctcc ttcccgccag acgccaaggc 121860aaagggcctc ctcacctttc acgatggtgg cctccttcaa gtggtgggac aagaagtcaa 121920tgctggcgta ggtgttggca gggggcaggg caccgggacc cggccccccg cacccgccgc 121980cggtgctgcc gacgcccaca gcgctgatga gacccccgag gcttcgggtc cggccccagg 122040agctcttgtc tcccggctga ggaagcggcg gcggcggcgg ctgcggctgg ggtggcagcc 122100cgggctcctc cctcacgtcg atggcgatgt agttgagacc attctggaag ccggcagagg 122160tctctctgcg catgggcgat ccaccgctcc caggacaacc gaccaagccc ccgggctgac 122220ccggggtcca cggccggccc tgcggtgcca aagggggcgc cggctgcaac tgtcgtgggg 122280aggtgggcgg ctcgtcgccc cctccagggc cgacacccac gccgccctcg ctgcttttcc 122340tgagagagac attttccacg gaggccgagt tgtggcgctt ggggttgtgg gcgaaggacg 122400gggacacggg ggtgaccgtc gtggtggagg agaaggtctc ggaactgtgg cggcggcggc 122460ccccctgcgg gtctgcgcgg atgaccttgg cgccgcggtg ggggtccggg ggctggctgg 122520cctgcaggaa ggcctcgact cccgacacct gctccatgag gctcagcctc ttcacgcccg 122580acgtcgggct ggccacgcgg gcagcttctg gcttcggggg ggccgcgata ggttgcggcg 122640gggtggcggc cacaccaaaa gccatctcgg tgtagtcacc attgtccccg gtgtccgagg 122700acaacgatga ggcggcgccc gggccctggg cggtggcaac ggccgaggcg gggggcaggc 122760ggtacagctc ccccggggcc ggcggcggtg gcggcggctg cagagacgac gacggggacg 122820cggacggacg cgggggcaac ggcggatacg gggaggaggc ctcgggggac aggaggccgt 122880ccaaggagcc cacggggtgg ccgctcgggg cgcccggctt aggagacttg ggggagctga 122940agtcgaggtt catgtagtcg gagagcggag accgctgccg gctgtcgctg ctggtgcccg 123000gggtgcctga gcccagcgac gaggccgggc tgctggcgga caagagcgag gaggacgagg 123060ccgccgacgc cagcagggga ggcgcgggcg gcgacaggcg ggccccgggc tcgccaaagt 123120cgatgttgat gtactcgccg gggctcttgg gctccggtgg cagtgggtac tcgtgcatgc 123180tgggcaggct gggcagcccc tccagggaca ggcgcgtggg cctcaccgcc cggccgcgct 123240ggcccaagaa gccctccggg cggccgccgc taggccgcac gggcgaaggc actacagggt 123300gagggggctg cgtggggccg gccccgaagg cgctggccgc ctggctgggc cctggcgtgg 123360cctgaggctc cagacgctcc tcctccagga tgcgccccac gggggagctc atgagcacgt 123420actggtcgct gtccccgcca caggtgtagg gggccttgta ggagcggggc aaggagctgt 123480agcagcagcc gggaacgccc ctgagcggct ccccgccggg gtgcagggct gcggagaaga 123540agtcgggcgg ggtgcccgtg gtgaccgcgt cgctggggga cacgttgagg tagtccccgt 123600tgggcagcag cttgccatct gcatgctcca tggacagctt ggaaccgcac cacatgcgca 123660tgtacccact gtcctcgggg gagctctcgg cgggcgagct ggccttgtag ccgcccccgc 123720tcgccgggaa tgtcctgccc gccgcagagg tgggtgctgg ccccgcaggc cccgcagaag 123780gcacggcggc ggcggcggcg gcggcggccc tgggctgcaa gatctgcttg ggggcggaca 123840cgctggcggg gctcatgggc atgtagtcgt cgctcctgca gctgccgctc ccactgcccg 123900cgagggccgc gccgggcgtc atgggcatgt agccgtcgtc tgcccccagg ttgctgctgg 123960agctcctgtg ggagccgatc tcgatgtctc cgtagtcctc tgggtagggg tggtaggcca 124020ccttgggaga ggacgcgggg caggacgggc agaggcggcc cgcgctgccc gagaaggtgg 124080cccgcatcag ggtgtattca tccagcgagg cagaggaggg ctggggcacc ggccgctgcc 124140gggctggcgt ggtcagggag taggtcctct tgcgcagccc tcggtccagg tcctgggccg 124200cgtcccccga gacccggcgg taggagcggc cacagtggct caggggcctg tccatggtca 124260tgtacccgta gaactcaccg ccgccgccgc cgtctcgggc cgggggcgtc tccgcgatgg 124320actcgggcgt gttgcttcgg tggctgcaga aggcgcgcag gtcgcctggg ctggagccgt 124380actcgtccag ggacatgaag ccggggtcgc tgggggagcc cgaggcggag gcgctgccgc 124440tggagggccg ctggccgggg ccgtggtgca gcggatgcgg cagaggcggg tgcgggccgg 124500gcggcggcgg gtaggagccc gagccgtggc cgctgctgga cgacagggag ccggggctgg 124560tggcggcggg cggcgagtgc gccacgggca tggacatgga gcggctgtgt tgcagcgcgc 124620cccctgccgg cagcagcgcc accttgctcc cgcggccgcc gcagccgccg ctcagggtgt 124680gcgagcggct caggggcgcg cgcaccggcc cggggctcag ggggctccca gccaccgaca 124740ccggcctggc gcccgcggcc gccgctcccg ccgccgcgcc gccgtcgccc tcgctggcgg 124800tgcgcacccg gcacgagctg cacttggccg ccggcggggt ggcggccagg ctgtcggtgc 124860gcgagcggcg caccaggccc gtctggctgg ggggcaggtt gaccaggtgg tggtggcggc 124920gcgcgccggg gacgctgatg gggtgcgtgg ccgacgaccc cgacgattgg ctcttactgc 124980gcggccggaa ctcgaagagc tccttgagcg ccttcatggc ctccaggatg gtctcgtgga 125040tgttctgcgc caccaccgag tcgtccgcct gcatccacag ctcgccgggg cctgtgacgg 125100ccgagcggcc cacctcgatg aagaagaagc tgtccgagtg gccgcagcgg cggatgttca 125160tgagctgcag cgtcaccgac ggctgctcgc agttgagctt cacgaagccg atggtgcgcg 125220cagacaggca cagacggtac acccccgtca ggttcttgct ctggcccaga cccttgggct 125280tcaggttcac ctgccacacc tcacggtagg cggccgtggc gggagccacc agcccgtagc 125340tgtcctcggc cccggcggcg ccggcagagc cgcccagggc gccgggcagg gaggcgctgc 125400aggacgcggc gggcgcggcg gcggggggcg cgtctccggc ggccgcgcgg ccctcgctga 125460ccaggtcggt gagcgcgcgg taccagccct cctgctcctg ctcgttctcg gcggccacgg 125520cgaagtactc gtccttggtg tagagggcga tcaggtactt gtgcttggcg tcggcgcgct 125580tgttgatgtt caggcagcag tcgagagcga tcacccgttt cggcgcgcct gccttgctcc 125640gccacttttt ctcgctctcg tagtactcga gccgcggcgg ttgcggcgcc gaccccccgc 125700ccgccgtcgc ctcgtcgccg cccgcgccgg gtccgcgcag cacgaagaag cgcttgtggc 125760catgcttctg cttgcgcagg tagccgcact tgcgcacgct gtggttgttg ttgttgttgt 125820tgttgttgag gttggggccg tctccgctcg ccggcccggg cggcccgtgc cgcggcgggc 125880tcgccatcgc gggcgcttca ggccgcgcgg cccgggcccg gcgcccaggg gttggggcga 125940ggggcggagg gggcgcgggc gggggcggct ccctcccacc cttgcgcccg gccgcccgcc 126000cgatcacgcg tccctcgggc ccaggcggtg gggaaggtcc ggggaggccc gcgggggcca 126060gcaccgctcg gcggcgccgc gccctccgcg ctctggggct cctgaggatg cccggcgcgg 126120gcggtggccg cccccctccc cggctgcctg cggccgctgc ctcctcgggc tctcgggcgg 126180cgccggggga cgcgctcgct gggccgggag tcggggtccc cgagccgcgg ggccgagcct 126240aaggcgcgcg cggccgcacc ggggctgctg ccgccgcgtc gcgctccggg aagccggggt 126300gcgcccgggc gctcggggtc cgcgccgccg ccggggctgc tgctgctgct ggtgttgctg 126360ctgctgctgc caacggcgac ccgggctcgt cgcggtcccc gccgcacagt gagtaacaca 126420tcgcgcaccg agtgactgaa ctaagaagag caaaacaaca tgtgactcgg cgttacgcag 126480gcacacacag cgcggccgcc ccgccccgct gcctcgcatt ggcgccgcgc cccccgacgg 126540acggcgcgct cggccaatcg gcgcggcgct cgcgggggcg ggccgcgcgc ccccgccccg 126600cccccctttc tccccgggcc gcgtttcccg ccgtcccctc cccctcccgc gaaggccccg 126660gcccggccgg gcggggtggg gcggccccgg cctcattaat cagcggcttg ttgtggatgc 126720cggcggagga gatgccaccc agggcgggaa aaggggcgcg gaagaggggc ggggcgggcc 126780acggcgcgca gggcccttcc ctcccgcctc ggactcaatt aattgggctt gagcttccgc 126840cggggagggg gcgccgggcg gggccgcggc tgggcggggc gggggatcgg gatcggcggc 126900gggggctgcg gccttgcagt ggaagcatgg gcggcgagcc gggccgtgct ctcggggcgc 126960ggggtcccca ttttgggcga gggcggccgc tcccgcgctc ggggtgggcg cgccccatcc 127020ccgtcccccg tttcccgtcc ccgtctcccg gccgcatctc cgtccccccg cagccgcgaa 127080acgcggggag gttccagggc ccgcggccgc gggttcgcga gcaccgcgct ccagatcgag 127140agcggcgcgc gcccttccgt ggaggacaga ggggcgcgga gggggcgcct gtgtcccacc 127200cgctcgcggg cgctttacgg ggcgtcctct gcgccattca cttgtcagct tgtcgggaag 127260ttgaaatcgc gtttgggagg taataggaga aagagatcgg ggacggcagg cggagaaagt 127320gcggtttcca tagcgccggg gagagggcgg acccgcgagc cagcggtccc tgagccggga 127380gaccgcgcgg gcgtctctcc agcccccgca ggagcgccgc cttccttccg caggggcgtc 127440ctctcccccc accgctgcag gagcaccccc ttccttcctc ggaagcgtcc tctcaccaca 127500ccgcttcaag agccccccct tccttccaca ggggcgtcct ttccccctcc gaggcaggag 127560cgcccctttt ccccccacag gagcgccctc cccaccccag gagcgccctg cgcccagcag 127620acgggcaggt gggcgggcgt ccactacctg tgtgcgcggt gcgggcggtg actgccaagt 127680tggagatgcc cttggagaac tgcttcgaat tcatgtatct actgggcttt tgtgactttc 127740aaagcctata gcaaataagc acccctgcaa ttacgtctcc tcaatgacca agtcagggtg 127800aggtgagggc ttcctgagtt cagatcccag caagctcccg atcctgcgca acgaagaaaa 127860ctcaacaaaa caggctttgg ctgtttattt tatttttttt ttaattgtgc cttcatgaaa 127920taatttacag caataattta tcttataata ttggttattg tttttaagtc ccggatgttt 127980acttttggat gtcctctata attcatagaa gtatcttaaa agtaataaaa tcttaatcta 128040agagaaaata agtgtaattt ttgaaagagt gatatatatt ttaatatgtt tttgtaacat 128100gtgacttgaa gattgtgttg gctaatttta tgtgccaaga gagccctgac tagtacaaag 128160attatagcgt ttttattttt agcatgtata cagttaggat tattgatcag tagcctgaat 128220ttgggaagaa taatcattgt ggcaaatatc acccagtgtg cctcaaaaag gtgtgtttaa 128280agttgatctt ccatttttaa atcatacctt aaaaaaaaat acctcaagaa atgccatttt 128340aagtctgtgc acctatgtgt gcatgtgtgc gtgtttgttt atataataga ttgtgtgatt 128400gtgtgtgtat aggtatgtgt gtatgattgt gtgtgttggg ggcgccacct ttatgaacat 128460tatgcttcgg cgttcttttt agatcttgtt accttttctt acgttcacaa atgttgccta 128520gcaatatgtc tagtcaggaa agatgaaggg attcttatct tggtgcttga agaaaatgtg 128580gtgtagtttt attggctttg tgatcactta catcccactt ttatgaggat gtaaatgggc 128640cacctctatg ttcctgtatg ttgccagcca tcagtagaca atgctaaagg aaccaccact 128700tttaaacatc atgtgatggt ttcttctgag aaagtatatt ttgcaatctt tttctttttc 128760atgttgactt ttattatgca gttgcatttt catatccgta ttgaacattt acttgctgtg 128820cctgtcacac gctagcaggt gtcatctttt cctgtttgct tgtttcttgg ggccatccta 128880gtgttaaagg ccagtgtttt taaggtgtca gcagctctgg attggcagtt agcactttcc 128940ccatgtactg cctcagttac cagactgggg acaaaagaga gaaggttaaa gaattatcac 129000ctatgtccgt ggtattctgt catagagagt ataaatttcc tacagcaaac tggaaattaa 129060ttgcaattct gcagttagaa cctccaaata caaatgtgga tgatacaatt tcaattctca 129120ttgagagtca gcccatgaaa caaaccaaca gtaagaaact ctgtaattag aagtatccca 129180gtcctcttcc tcaaccgagg aacttgtttt ctttccccct ttctattgcc agataagcta 129240tttatttatt taaagcttgt tctacacctt gtgattttcc aactgttctt ccatactttt 129300tcaacaaaag tcagctaata acatctgcca acatgctctg cacgcaggac tggctggggc 129360tggcatggcc tcttgccagc aaacagcctg gttgaaattt tttctcatgg tccaagatct 129420ttccttggaa gctttctttc ctttcacagc taataaaatg gccatatctt tcagcaggga 129480gttttttctg tttgtttgtt ttttctattt ttaacagaat catatacaat aatgattatt 129540ttattagaag tcttctgaaa taattacttt tcaagaaaga atcaattata taaaagtgta 129600gagatttaaa aatatgttac aggttcacaa tacaaatact agtagcacta ccaataatga 129660acatcactaa ttattttctt tgtttcatat aggaaaggca agtatgggag gagaaaggtg 129720aatagcattt tattgcttgt gaaattttct ttcttttttt agttctttgc cctgtaggtg 129780tttgacagta ttttgtattt aggtgagctc aatctaaaaa ctaagcagat taagtggaat 129840gctatataac tagttagaat agctttaatt taaaaggtat tttaagaggg aaagattttt 129900aacttcacag gtttctgtca aaggatatat ttaatcttta aaatgagtgg caccatttca 129960ttatatttca ttttattaga taatgttgtt cagtagctca tttgagaaat tccattcctc 130020tgatgaacga actgtggaca gacttttcct catctagggt ttataaggaa acttcttgca 130080ctttaccagc aaatttattt gctaatgttt caactgaaat ttcacaagag ttttgtaaca 130140tgctaactct gtgtatgggc aacagaatga cttacatgag agaatataac tgctgtttgg 130200atcatttgct atgtatggca ttgcaaacat ttaaagtatc aggatttgtt aatggaattg 130260atcagcccct tggaaattat aaaggctttc tacttgtgtg tttattattc ttgttaaaaa 130320tatggatcag tctctttcct aaatgttcat tttatgaggg aggattttct aaaataaatg 130380attatttaat gtgcatatat gatagaacaa actactataa cttttttaaa gtcttatcaa 130440ttgaattaat actgtttaga aaaatatgtt gtagttacaa atgcagctaa tccagtattc 130500tcaacatttt ttcattataa atataattat gttgaagaaa tacataaatg cccaattaaa 130560aagtgactgc ggttaggagt tgaaaatatt tattaatatg cctctggatt ttgttctgtt 130620tgaattttga gaatgtgttt ctagatttaa gaagcaacac aagctttttt tcccagaagg 130680cttcctatta ttgaaatgga aattatacat taatgactgt ataacactag tagatatttt 130740taaaatgcaa gagcatcttc ttagatcatt acttttcctt ggaatgcttg gcccctgtaa 130800tataatacac cggtattttg catgatgaaa ttgatgtcct gtgtgttgct tcatgttgct 130860atcctagctg ccgattaaaa cgtttttttt ttttcatgcc agagcagaac aaaattgtct 130920gcttctcaat ctgcacatca taagcagatg acattaaaaa tgtctgtaag atgacacagc 130980tatattttct gggagagggc gggaggatgc tcagcgaggg tggcccggag tgtccttgta 131040cagagtacag atgttatgaa gtggggaaga ccagcctgtg ttcattgatt cacctattga 131100ttccaggagc aagctcaccc tgtttcatac actgctcagg aggtaaacag gaggaaggga 131160gccagcctgg cttttttgcc acatgctctg ctgtttggta gaactgtatt atagtcagaa 131220accttccgct tttctgcagt tgtttgcatg ctgtttccaa ggctagccct ctgagtctgt 131280tttctagagt tgttttgaaa ttcaacctaa agataacaga ggaaatgtga ccctctcttg 131340tgaatgctgc caccaactgg caatgtttct tcccaaggca gattcagggt tctggcatga 131400gttgtcacaa atacagtggt ggttgctttg agagaaaggt gcttacaacc tgacataaat 131460ttgctttgca tgaaacttta aggaaattaa tagaagtaag attaaacaaa gaaattttga 131520tagtgagtga ctaagagcaa tatcagatga caaatgaggg aagagaacat taataagtgc 131580aatactttat tttttatggt tgaattaagt atcaagcaaa tatgttcata ttttctaatg 131640caatttatat cccaatttgc atagttactt atacagttta atagaaatgt atatcactgc 131700ccacttaaga gtttagaata ctagccaaca aaataaaaac aagaatctaa attcagtatt 131760attttagaat gtttacctaa tcaaaaataa gttataatca agatttgctt atctggcaag 131820ccaagtgttt tttaattgta tttctcccct acattgacct ttaagtctca cattcttttt 131880aggataagcc aaagtcatct tgaaagattg aaaagcaaat tggaaaaagt aagataggaa 131940agaaaacata ctctgaaaat gacacataac aaaaatgtat tttaaaaaca taaataacaa 132000atggcaataa gcatcgaatg tcactatctt tttgattgcg taaaattatt tgaacttaca 132060tactcattac taatttggca attctaaatt tacaaattac accttccttc ttaactgctt 132120tattctcaat ctttaggcat tgcaaataga agatattcaa gttagtcaaa gtgttcagag 132180ctgttattca atagagtgaa gggatctgaa aacttatttg ctactgaaca tgtcgttgag 132240gtacttttat ggatgaaaaa aagttgatat ataaaatatc aataatagta atagcttgtg 132300agagtagttt gtcagtatac tcacaaagat catgaatttg acgcttacta gtatgaggga 132360taaataaaaa acattttata atatgtagct accataaaga tacgattatg acacaactga 132420gaattgagcg gtcttttaat tctccttttg agtaatcttt accaacctgt cctctgagcc 132480tccgtgtata tgctatgttt aagaccaatg attagctatt tatacatgaa ttttccattt 132540ttccttgttc aaaacacttt tgtcacacaa ataatattaa ctaaactaaa gtgacttgag 132600ggagtatgga ttaatgaggt tcacaagaaa ataaataaag caacaacttg tgaaatttag 132660ggcagatgcc atttattgcc atttcccgct gactgttaag tagagatttc agttcagata 132720aacacattct aagaattact actgaaagtg taaacatcag cctgcatttt agtacttgct 132780ggttctttag taaaaatttc gaatgtcagc ccaaggttgt cttgctaaaa gagaaaaaaa 132840ataggaatta tatattgaaa acatcttaaa attatatttt atactacaaa aatttccttt 132900taggtagtaa aagtgagaat ttaaaaacat gattctcact gctactaaaa gcacacagaa 132960aatgaaatac atatttttga gacttgatac ttacctgttt tattttgata aacttgtacc 133020tagttttaaa gtttcttcac actaaaagta caccacaatt tcaaaatggc acccttgtct 133080ctcacaatat aaactttaaa ggaaattaat atctagatca tcattttgct ttgttgtttt 133140aaatatcatc atgttttagt tacagaataa tacaaaagtg ggctcaccct ttatcgtgaa 133200ggtgcattta tggcattttc aattcaaaat ataaaaatcc gcaaacattg ttactaaaaa 133260tgtgctagat atttgttaag cctcaaacgt atactaagaa ttacccagaa cataggtctt 133320tgccccatta gctttctgtc taagtaataa ggcactattt tcctcaacta tttctttcct 133380caaatatttt tttcttgtgt cttttgttac aatattgcca cacataattt gaagataaaa 133440attgccatat attataacca tcatctggct tttttaaaaa aactttctta gtgcttgatt 133500ttaatgtcca atgctgcaat tttaccttct tcttactaat ggtgtagagt agagaaagtg 133560acttttatct ctgagctgag gaagtttcta aatttcattt cacagaaatt agttttaatg 133620agtcaaacag taattctatt tcttttattt ttaggttgct tcctttagaa ggtaccgttt 133680tggactcttg acgctgcctg ggtccatagt gtgaggaccc atctgtgtag tagagaataa 133740tactcaatag atgtagtgat gtagttatgc tgtgtggtgg taaattcatt

ctaacccagt 133800gaaatgttgg attcggtcaa atttatcaac gtttcttaag cacctacttt gtactagaca 133860ctgatcctgt ggacatcaaa atgcaaaccg accacaacca ctcagctgtg tctgctggga 133920aaggccctcc tctgtgcgtc tctcctgctc ccacgcctgt tagtgggtca gtgaaatacg 133980caagaccctg gctttgcttt actcaagcct tttttaaggg ttgtgcttgc agcaaaccac 134040actaagaggt gaggtcgcat tccagaacaa agtgcgggcc tgcttatttc ctgctacaaa 134100aatggtggat tacccaagtc ctttgtgtca gccgaaacac agcccactgc aggcgtggca 134160tccaacaggc cccgccctgt tgccccatgc tgcccgggaa gcaagaggaa tagaggcaag 134220tcatgccact ttctgtgcca tgagtctctg accggaaagg cttacatcct ctgccagcat 134280ccacctaacg gtgacgggct aacattactt tctaagggaa agggagtaaa atctcaaacc 134340ctgacagtgt gcttaggaag ctcacaaatc agtgggaggt ggagaaccta catgaacata 134400gccaaatcaa aaggtcagtt gtatttggta cagaactaaa tctagataca agggacaaag 134460catattataa agctggcagt ttatttcatt ggaggataag agattattca gtaaatgggg 134520ttggcagaac cagaaaatat acctgtagac acataaaaat tagatgcctg tgtcctttca 134580ctaaaatgtc aggtgaagca aaaaattaaa tattaaaaca tgaaaccata aaaccaagta 134640gaaaagtaaa gaaatattga taaacttgac tttctaaaat aggattctgt agggggaata 134700cagtaaaaac aaaacaaaaa cagtaaaagc aaagttaaag tagaagctgg aaggaaattg 134760cagccagtat catagatgaa gtgctaatga tgcttattta atactttaaa agagcgctgt 134820aaaaaataag aaactaaaaa cattctaaaa attggtgaat gacctgaata caaatttcac 134880aataatgaaa attaatgcaa gaaaggctta aatgtgtgaa agtttgctta acctttcttg 134940taataagatg aatgcaaatt aaaaccacaa tgtggtagaa tagttcacct atcagattgg 135000cacagatcaa gaagtttgat aacacggtgt gtttgccaga atgttgggaa acaggttccc 135060acccaaggct gctggtggta cagactgaac agcatctata caatttggct gtatctgtca 135120aaacgacaaa tgtctcatgt tccttgaccc acaatctaat ttccaggaat tactcatgtg 135180gatgggaaat gacttcttta taagggtgtt cattgcatta ttgttaggaa tagaaactta 135240tacacatgat tacagtattg tcttgtaatg gcaaaggttt gaaccctatg caactgtaac 135300acaaacgagg cagctctgtt tatactgacc cagaataata tttgactgta taatgtgagg 135360tgggaaaaca agcttcagaa cagtgtgtat agtatagtac aaccattttt tttattttta 135420aaacgtgtgg gtatgtgcac agatacctac tgcaagtgac ctcacaaata tggcaatgcg 135480aggagccaac ctggcttcct ggggaaggga cgggttgggg agaggactca cgtttcatcg 135540tgttactttt cggactttcc gaattttgta gcacaagtat gtatcaaata tttaacagtg 135600taaaaataat tgactttaat ttctaaaggc tcagtagcac ttggtgatga tttgggggta 135660ggggaggaag agaggacctt cagtgtcctg cactgtcgct gggtgatgac aaggtcttct 135720cctgagatgg gggagggaga gttaagagat ttattttgga cacacgaggt tggacataat 135780agaaatctga gagaagatgt tggataggct gttggagagg cttggaatgg agatattaat 135840ttgggattca tgggcatcta gctgcattta agtccctagg atttgccgaa agtgactgtg 135900agagatgaga ttggagcacc tgggattgga cccaactact cttaacattt agaagtcagg 135960gacagaaagg taatctagca gagaaaacgc aatgaaaggg cacagactag cttgctgaag 136020aaccacggga gtggacagca gagagcattg cagcagggac tggccagcca ggggtaacga 136080ggatgagtgg tccaggcagg ggacctggtg acatgggagc catgttgatc tagtgcgtgg 136140tttcctggtg tgaggaagag gggaatgcag cctggagaag gcatgacaga tggggcagga 136200tccatgagaa tgaactttca ataaatgaag tctttgcatt atgaattcaa agtgctattt 136260agcagaaaca ttggagaacg agaagaatcc gaaggaaaat ccaggggcaa aataagcatt 136320atcctccggg agcagaagag tcagtgtccc caggatgcag ccagctttca ggaaaggctg 136380agactcagaa agcatgggag tagtgttgca atggaaagga cacttgagag aagacactgg 136440aagtgtttgg gaggtaaagg agtgaaaaag ggctgggtga aaggaaaaca tcagttagga 136500taaccccatg ggagaaagtg gatagctcta agggcttcta ctgtgggcag aaatatgacg 136560catggtaggt tgagttgttt gtttcgtttt gttttgagac tgagtcttac tctgtcaccc 136620aggctggagt gcagtggcac aatctcggct cactgcaacc tctgcctccc aggttcaagc 136680aattctcctg cctcagcccc tgagtagcta ggactatagg cgtgcaccac cacacccagc 136740taatctttat tgtatttttt gtagagatgg ggtttcacca tgttggctga gttggtctca 136800aactcctgac ctcaagcaat ccacctgcct cagcctccca aagtcctggg attgcaggtg 136860taagccatcg tgcccggccg gtaggttgag ttttaatggt gtctgtgaag atgcaagttc 136920agctgtagcc tggaagtgtg acctggcatc tgagaggagc actgcagcac cccttttctg 136980tgctgcttgc attggcatcc atggtgagtg cagcaatagc tgtcatcagt gagcaaagag 137040gctccagcca ggggccctgt ggtgcctaca gggagaggca gagatctggg tgtccccagg 137100tttttctgct tgagtcaaag cccctgggag cccaggtatg aaaacctagg ggcttccatc 137160atgtccggat ggtgggtctc catcattcct cttaatctca tggttttctt gcaaagctga 137220agaagcccca ttatgggctt ttcctcaaat tgaatgtcat cttgcaacat ctcttcagct 137280ttgcattttt ggaacatgga tcagaatctt tcctttcctt gactcccttt ctagcagctt 137340gttagaatgc attcatgtag caactgggaa tgaatgcgac acatttacat ttaacacctc 137400ccttccattg acttcagctc agacctttcc agagatttct ccattagagg actgttagat 137460gccactagac gtgtgagacc aaatgatgtt ggcatcatct tggaatagag acggagactg 137520gggtctggcc tttcttctgg tcctcagtcc tgcaggctgt cctttctcca ctgcacctcc 137580tcaaggagca ttcctggtag cctctggaac ctgccctggg tgtgttttgg ttcactctct 137640atgcttgata ggctttctca aagaacctgc tgcatcgtaa gtgctcaaca cactcttttc 137700aggattgttc ttttatgttt ttagattaca attttatgta atttttttct gattaaatac 137760tttttgtgtg gctacggaaa agttcacata aattaacaca ttaaagacct ttgaaagctc 137820ctgactggca cagtagacac agccagtaca tattggctat gatcgtttgt gttctgtatc 137880agattggttt acaggccaca aagatggggg ccctacggat cctctctgtt caagcagtga 137940agagctggta tctgaggata aaagaagctt gtgttgtaat gatgtggaaa ttccagaggt 138000tgtgatggaa tgaatgacct agaatagaga agagcaaagc atgttgggag cagggaggtg 138060gaaaagggag tataggaaga ggggaagagg ggtcccagtt ggcctccagg tttctggaag 138120taccaatcct agagtcttct tggtgaaggg agttggccaa ggcaaggaaa cctgagccct 138180ttgtgaagga gtcagaggag gtttatgact aaaaaatgac aaattatgcc atattacgta 138240ttctgaacaa atatgtgtaa atacatgatt tagataaatt aggtatttat taaatatttc 138300aagatttggt tccagaagag tacaatttgt ctcttcacca ttgttagagg gaaaaaaaca 138360ggtaaagcca atcaaagaaa gatgaaagtt tttagaggaa aaaaaaatct agttttgcag 138420caaagaggat taatctgtaa agtctcatct tatagatgtg ctactgtagt aatctagaat 138480ttgtttcttc ttattcttca tttcccaaca gtattaagat gaagtgtgta atctttagaa 138540ctagagagaa gtctgtttgc atctgtgggg ttaatgcaga gagggaggtg agaggtgatt 138600cttgccatac ttggtcactt gaataaaact acctattccc atggctttct ctttagggag 138660tagaaaaccc tcatttcaat gaaatcagtg tttttcataa ttggaagcct accttccaag 138720agctaatggc atataatgga aatgaattat cccttgctac ctaaacactt gcttcctaaa 138780ctcatattta actgtgtaag gatatttata ttaatttagg aagtttatat ctaagcaggg 138840atttcccttt aacgaatgaa acaatatgca tactggcaag gtagaaaatg ttttcaattt 138900gcattttgtt gtttggaggc ctatttaatt cattgcaatc ttatttattc agtgatgtat 138960attaaacata aatgtattaa aaatctacca ctagaaagta ctaattgtca ttgaatggca 139020cattttaaaa tgaataattt catgttatgt aaatgctgcc taaaaactat aatagaactg 139080ccatgattaa gacattatgt ctacacagag aaggttaaag taacaatacc ataactactg 139140tccttttata aataaacaaa taaaaacata atatttattc caaaggacat tcttgtgtcg 139200aaagatgaaa cagaaagaaa gtggaagata gtaacagaga aagtggaaaa aaggacgaga 139260agggatagac atgcaaaact ccagcattcc aaagttaagg gaaagagaat aaccatgttg 139320tgcctataac cctagaagat tacaaaaatt atttctagca aattgacaac ccttctttct 139380gaaggtagct ttgggcaaaa aggtgctgtt ttgagctttt accctgaatc acctggggtg 139440cacttgaaaa gaagccattt tgccaatgca ttaaaagtgt ctgagtgaaa gctgccactt 139500gattgtccta agaggctttt aaccccagcc acataattat ttcataacaa acaatcagga 139560acatttctct tcctcatcag tttcccagac tacctcatag cacatgcatg atacaatgtg 139620tgattttgca gccttccatg taacatcgga gtcctaaaga gatggacttg aagaggctca 139680tggtgatttt aattgcattt tgaaatgcca cacatattct aagagatgtc attctaagag 139740atgtcatcaa tctcttaaaa catgattttt aatggctgca taccattctt ctaccccatt 139800gtaccatgat tcatttaacc acctcttaat acttgcttcg ttttggtgtt tctaatttct 139860tgcaaataaa aatttaactg cccttgctaa tgattatttg gtaggtgatt cttaccttga 139920taagtaggtc accatctatc cagttgtgca gctggaaacc tggaaatcat tcttgcaata 139980gttttcaccc cgaatcccaa tccattgcca aattctgtca attttctatt cttagtatct 140040ctcaagctta ttcacttctt tccacccctc ataaatattt ttgccgtaat atttctgaat 140100tccttattgg ttcagcaata tactaggtat ttattatctt ttatttttca cacctatcca 140160ttgttactct tcttccaatt tttctctcaa atttttgatg aaattcagtt tatttacctt 140220aagaactttt attttttact tattggattt ttatattgtg caacatagta cacacataca 140280aaaagatatt taacatatat gtaagttata aataataata ctttaaaatt ggcatagtca 140340agcctaaaaa gtaggacatt accaatattt attttgaagt ccactgacta gccttatcac 140400aatctgaaat tttgtgatta ttgtcctttg gctgtcttca tgattttact ggatatgtat 140460gtaaacattt tgcattgtac ttaaatttaa gcattataca aatattatca tcctattaat 140520attcttctgc aacttgctca acagtatggt tttattattg agatgtaact tagataccat 140580aaaaatgtac aacttaatat tttttagtat aatcacaagg ctgtgaaatt gtcatcacac 140640tctaagtctg gaatatcttc atcaccccaa aaagaaaccc caagaaactt tgtgcccaca 140700gcagtcactt ttgagttccc ctcccttcac ccctggcggc cataagtctt ctctctgtcc 140760ctgttcatcg ttatgttttt gagagaaatg tattacgatt tctgaagtcg tagttcatct 140820ttttcagttg taataaatat ataactgttt ttcacttctg ccaatagaaa tttaggttat 140880ttgtagttgt ttttaaaatt tctatttgaa catgacttgt ttttttaaaa agtatgtttc 140940acaattacac accttttaac aattaaagtg ccttttaaca attatttatg catacatata 141000tattcttagg cacactgttt tagacagaag aatagaattg ccagtgttaa ttctgtccac 141060ctttaatttt aatgtgtaat aaaaatcatt ttcgaaagta agtgtacaaa ttgaaaattc 141120caccaataag gtgtcattgt cttttacaat ttttcccatt ggattgtagt cattgtttat 141180agaggccatg tgttaatctt ttataaaaat cgatttgtca aatttattat ttgcttttta 141240ttttctttat gttttctttt gaatgaacat caattttaaa ttttaactga gtaaaattta 141300tcaagtttac cttttgagtt ttgtgccttt ttcattttgt tttaattttt ttctctatcg 141360ccaaattttc aagtacttac tcctgtattt cctttctctc tctctctttt tttagcttta 141420attcacctgc attatatgtt tgtgcatggt gtctgatagt ggctcaattt cagttttttt 141480ttaaattgtt tccgaggcgt gtttcaaata tttgactttt tcccactggt ctgaatagtg 141540cttctcagat acggcaagtc tctaggtttg catgagtcag cctctgtgcc ctctgttctt 141600ttccccgatg ttctttttgc ttcttcttat gctattacca cactgtctta attactatat 141660tttattaaca aatctcactt tctggtagac catttccttc acctacttct tcactttcct 141720tcaggaatgt cttggatatt tgtaactctt ttccttatga tttagcatca gcttgacaag 141780tttaataaac cttgttagga ctgagataaa attagaaaga ttggacatct ttaaggtact 141840gagttctcct agccaggaat gtggcacgtt tccctatttc tttagggaat tgtaaaatgt 141900ctttttataa cgttttataa ttttccccat agagatcttt aaaatatttt gttagattta 141960ttcctagcac cttatatatt ttgttactct tgtaaaaagt atcctttttt tttttttttt 142020ttttagaaac ggagtctcgc tctgtcgccc aggctggagt gcagtggcac gatcttggct 142080cactgcaagc tccgcctccc gggttcacgc cattctcctg cctcagcctc ccgagtagct 142140gggactgcag gcacctgcca ccacgcccgg ctaatttttg tatttttagt agtagagacg 142200gggtttcacc gcgttagcca ggatgttctc gatctcctga cctcgtgatc cgcccgcctc 142260ggcctcccaa agtgctggga ttacaggtgt gagccaccgc gcccggccag tatccatttt 142320taaaaactac attttctctt tgttgcttgg gtagagaaat aaaatcaatt tttaatttat 142380cttatatctg atcattttgt taaaccctca tattaatttt aatgctttaa agatgtttag 142440agggaaatat tttataaata cacaaataat accatttcat gtgtcgctta cagattttct 142500catcttattg aactggctag agccaccaat gtatgctgta aaagcaacct tgttttaatc 142560ctttttgaaa gggaatgttc cagattctac catgtggtac catgtttgtg ctaagatttt 142620ggtaggttca atttttttca gtttaaagaa gttctcctct agcccattat gccaatgaat 142680ttaagctgaa tggatataaa aattaatcaa atatttttta gtgcctactg aggtgatctt 142740acgcctttct agtttgattt ataagtaggg ctaactatat taattgattt ttcaatgtta 142800aacaaaattt acatttctgg aatagattta acttggtcgt tctttaactt tgcgttcccc 142860ttaaaaagga ccttgagaga agggctcagc gtctgatagt tccagcatct ggctgtggag 142920ctgtatggct gagtcatcat ctgttggttt gtttgctgac ttccaacctt tgtgcctaga 142980tattgaagtc accttctctc cctttgaagg gcagagactt tgtgtgtttg tcctttcact 143040cagcatggct cttggagttt ctggctgcat gagaaggtcc tgggagactc ttcccttcca 143100agagcctcca tgttgtcttc tgccttttgg ggctactgaa accgcagcac aaggtgtagg 143160gaaattacca ggttccccca gagccgtcgt tccttgcacc gcctttccac gatgtgtgtg 143220cccccttttg ttttgtcccc tgggatttct cctacactct tgcgaggtca ttatgaactt 143280aaaaggatgt ggatttttat tttattttat accttagagg tcttttatag cagagatttt 143340tcagggcatc aagactagac gttttgccca aaagggaaaa ccagaggctt tcaatttttt 143400tttgaattc 14340919143409DNAHomo sapiensmisc_feature(1)..(143409)Reverse complement of AL162497 19gaattcaaaa aaaaattgaa agcctctggt tttccctttt gggcaaaacg tctagtcttg 60atgccctgaa aaatctctgc tataaaagac ctctaaggta taaaataaaa taaaaatcca 120catcctttta agttcataat gacctcgcaa gagtgtagga gaaatcccag gggacaaaac 180aaaagggggc acacacatcg tggaaaggcg gtgcaaggaa cgacggctct gggggaacct 240ggtaatttcc ctacaccttg tgctgcggtt tcagtagccc caaaaggcag aagacaacat 300ggaggctctt ggaagggaag agtctcccag gaccttctca tgcagccaga aactccaaga 360gccatgctga gtgaaaggac aaacacacaa agtctctgcc cttcaaaggg agagaaggtg 420acttcaatat ctaggcacaa aggttggaag tcagcaaaca aaccaacaga tgatgactca 480gccatacagc tccacagcca gatgctggaa ctatcagacg ctgagccctt ctctcaaggt 540cctttttaag gggaacgcaa agttaaagaa cgaccaagtt aaatctattc cagaaatgta 600aattttgttt aacattgaaa aatcaattaa tatagttagc cctacttata aatcaaacta 660gaaaggcgta agatcacctc agtaggcact aaaaaatatt tgattaattt ttatatccat 720tcagcttaaa ttcattggca taatgggcta gaggagaact tctttaaact gaaaaaaatt 780gaacctacca aaatcttagc acaaacatgg taccacatgg tagaatctgg aacattccct 840ttcaaaaagg attaaaacaa ggttgctttt acagcataca ttggtggctc tagccagttc 900aataagatga gaaaatctgt aagcgacaca tgaaatggta ttatttgtgt atttataaaa 960tatttccctc taaacatctt taaagcatta aaattaatat gagggtttaa caaaatgatc 1020agatataaga taaattaaaa attgatttta tttctctacc caagcaacaa agagaaaatg 1080tagtttttaa aaatggatac tggccgggcg cggtggctca cacctgtaat cccagcactt 1140tgggaggccg aggcgggcgg atcacgaggt caggagatcg agaacatcct ggctaacgcg 1200gtgaaacccc gtctctacta ctaaaaatac aaaaattagc cgggcgtggt ggcaggtgcc 1260tgcagtccca gctactcggg aggctgaggc aggagaatgg cgtgaacccg ggaggcggag 1320cttgcagtga gccaagatcg tgccactgca ctccagcctg ggcgacagag cgagactccg 1380tttctaaaaa aaaaaaaaaa aaaaaggata ctttttacaa gagtaacaaa atatataagg 1440tgctaggaat aaatctaaca aaatatttta aagatctcta tggggaaaat tataaaacgt 1500tataaaaaga cattttacaa ttccctaaag aaatagggaa acgtgccaca ttcctggcta 1560ggagaactca gtaccttaaa gatgtccaat ctttctaatt ttatctcagt cctaacaagg 1620tttattaaac ttgtcaagct gatgctaaat cataaggaaa agagttacaa atatccaaga 1680cattcctgaa ggaaagtgaa gaagtaggtg aaggaaatgg tctaccagaa agtgagattt 1740gttaataaaa tatagtaatt aagacagtgt ggtaatagca taagaagaag caaaaagaac 1800atcggggaaa agaacagagg gcacagaggc tgactcatgc aaacctagag acttgccgta 1860tctgagaagc actattcaga ccagtgggaa aaagtcaaat atttgaaaca cgcctcggaa 1920acaatttaaa aaaaaactga aattgagcca ctatcagaca ccatgcacaa acatataatg 1980caggtgaatt aaagctaaaa aaagagagag agagaaagga aatacaggag taagtacttg 2040aaaatttggc gatagagaaa aaaattaaaa caaaatgaaa aaggcacaaa actcaaaagg 2100taaacttgat aaattttact cagttaaaat ttaaaattga tgttcattca aaagaaaaca 2160taaagaaaat aaaaagcaaa taataaattt gacaaatcga tttttataaa agattaacac 2220atggcctcta taaacaatga ctacaatcca atgggaaaaa ttgtaaaaga caatgacacc 2280ttattggtgg aattttcaat ttgtacactt actttcgaaa atgattttta ttacacatta 2340aaattaaagg tggacagaat taacactggc aattctattc ttctgtctaa aacagtgtgc 2400ctaagaatat atatgtatgc ataaataatt gttaaaaggc actttaattg ttaaaaggtg 2460tgtaattgtg aaacatactt tttaaaaaaa caagtcatgt tcaaatagaa attttaaaaa 2520caactacaaa taacctaaat ttctattggc agaagtgaaa aacagttata tatttattac 2580aactgaaaaa gatgaactac gacttcagaa atcgtaatac atttctctca aaaacataac 2640gatgaacagg gacagagaga agacttatgg ccgccagggg tgaagggagg ggaactcaaa 2700agtgactgct gtgggcacaa agtttcttgg ggtttctttt tggggtgatg aagatattcc 2760agacttagag tgtgatgaca atttcacagc cttgtgatta tactaaaaaa tattaagttg 2820tacattttta tggtatctaa gttacatctc aataataaaa ccatactgtt gagcaagttg 2880cagaagaata ttaataggat gataatattt gtataatgct taaatttaag tacaatgcaa 2940aatgtttaca tacatatcca gtaaaatcat gaagacagcc aaaggacaat aatcacaaaa 3000tttcagattg tgataaggct agtcagtgga cttcaaaata aatattggta atgtcctact 3060ttttaggctt gactatgcca attttaaagt attattattt ataacttaca tatatgttaa 3120atatcttttt gtatgtgtgt actatgttgc acaatataaa aatccaataa gtaaaaaata 3180aaagttctta aggtaaataa actgaatttc atcaaaaatt tgagagaaaa attggaagaa 3240gagtaacaat ggataggtgt gaaaaataaa agataataaa tacctagtat attgctgaac 3300caataaggaa ttcagaaata ttacggcaaa aatatttatg aggggtggaa agaagtgaat 3360aagcttgaga gatactaaga atagaaaatt gacagaattt ggcaatggat tgggattcgg 3420ggtgaaaact attgcaagaa tgatttccag gtttccagct gcacaactgg atagatggtg 3480acctacttat caaggtaaga atcacctacc aaataatcat tagcaagggc agttaaattt 3540ttatttgcaa gaaattagaa acaccaaaac gaagcaagta ttaagaggtg gttaaatgaa 3600tcatggtaca atggggtaga agaatggtat gcagccatta aaaatcatgt tttaagagat 3660tgatgacatc tcttagaatg acatctctta gaatatgtgt ggcatttcaa aatgcaatta 3720aaatcaccat gagcctcttc aagtccatct ctttaggact ccgatgttac atggaaggct 3780gcaaaatcac acattgtatc atgcatgtgc tatgaggtag tctgggaaac tgatgaggaa 3840gagaaatgtt cctgattgtt tgttatgaaa taattatgtg gctggggtta aaagcctctt 3900aggacaatca agtggcagct ttcactcaga cacttttaat gcattggcaa aatggcttct 3960tttcaagtgc accccaggtg attcagggta aaagctcaaa acagcacctt tttgcccaaa 4020gctaccttca gaaagaaggg ttgtcaattt gctagaaata atttttgtaa tcttctaggg 4080ttataggcac aacatggtta ttctctttcc cttaactttg gaatgctgga gttttgcatg 4140tctatccctt ctcgtccttt tttccacttt ctctgttact atcttccact ttctttctgt 4200ttcatctttc gacacaagaa tgtcctttgg aataaatatt atgtttttat ttgtttattt 4260ataaaaggac agtagttatg gtattgttac tttaaccttc tctgtgtaga cataatgtct 4320taatcatggc agttctatta tagtttttag gcagcattta cataacatga aattattcat 4380tttaaaatgt gccattcaat gacaattagt actttctagt ggtagatttt taatacattt 4440atgtttaata tacatcactg aataaataag attgcaatga attaaatagg cctccaaaca 4500acaaaatgca aattgaaaac attttctacc ttgccagtat gcatattgtt tcattcgtta 4560aagggaaatc cctgcttaga tataaacttc ctaaattaat ataaatatcc ttacacagtt 4620aaatatgagt ttaggaagca agtgtttagg tagcaaggga taattcattt ccattatatg 4680ccattagctc ttggaaggta ggcttccaat tatgaaaaac actgatttca ttgaaatgag 4740ggttttctac tccctaaaga gaaagccatg ggaataggta gttttattca agtgaccaag 4800tatggcaaga atcacctctc acctccctct ctgcattaac cccacagatg caaacagact 4860tctctctagt tctaaagatt acacacttca tcttaatact gttgggaaat gaagaataag 4920aagaaacaaa ttctagatta ctacagtagc acatctataa gatgagactt tacagattaa 4980tcctctttgc tgcaaaacta gatttttttt tcctctaaaa actttcatct ttctttgatt 5040ggctttacct gtttttttcc ctctaacaat ggtgaagaga caaattgtac tcttctggaa 5100ccaaatcttg aaatatttaa taaataccta atttatctaa atcatgtatt tacacatatt 5160tgttcagaat acgtaatatg gcataatttg tcatttttta gtcataaacc tcctctgact 5220ccttcacaaa gggctcaggt ttccttgcct tggccaactc ccttcaccaa gaagactcta 5280ggattggtac ttccagaaac ctggaggcca actgggaccc

ctcttcccct cttcctatac 5340tcccttttcc acctccctgc tcccaacatg ctttgctctt ctctattcta ggtcattcat 5400tccatcacaa cctctggaat ttccacatca ttacaacaca agcttctttt atcctcagat 5460accagctctt cactgcttga acagagagga tccgtagggc ccccatcttt gtggcctgta 5520aaccaatctg atacagaaca caaacgatca tagccaatat gtactggctg tgtctactgt 5580gccagtcagg agctttcaaa ggtctttaat gtgttaattt atgtgaactt ttccgtagcc 5640acacaaaaag tatttaatca gaaaaaaatt acataaaatt gtaatctaaa aacataaaag 5700aacaatcctg aaaagagtgt gttgagcact tacgatgcag caggttcttt gagaaagcct 5760atcaagcata gagagtgaac caaaacacac ccagggcagg ttccagaggc taccaggaat 5820gctccttgag gaggtgcagt ggagaaagga cagcctgcag gactgaggac cagaagaaag 5880gccagacccc agtctccgtc tctattccaa gatgatgcca acatcatttg gtctcacacg 5940tctagtggca tctaacagtc ctctaatgga gaaatctctg gaaaggtctg agctgaagtc 6000aatggaaggg aggtgttaaa tgtaaatgtg tcgcattcat tcccagttgc tacatgaatg 6060cattctaaca agctgctaga aagggagtca aggaaaggaa agattctgat ccatgttcca 6120aaaatgcaaa gctgaagaga tgttgcaaga tgacattcaa tttgaggaaa agcccataat 6180ggggcttctt cagctttgca agaaaaccat gagattaaga ggaatgatgg agacccacca 6240tccggacatg atggaagccc ctaggttttc atacctgggc tcccaggggc tttgactcaa 6300gcagaaaaac ctggggacac ccagatctct gcctctccct gtaggcacca cagggcccct 6360ggctggagcc tctttgctca ctgatgacag ctattgctgc actcaccatg gatgccaatg 6420caagcagcac agaaaagggg tgctgcagtg ctcctctcag atgccaggtc acacttccag 6480gctacagctg aacttgcatc ttcacagaca ccattaaaac tcaacctacc ggccgggcac 6540gatggcttac acctgcaatc ccaggacttt gggaggctga ggcaggtgga ttgcttgagg 6600tcaggagttt gagaccaact cagccaacat ggtgaaaccc catctctaca aaaaatacaa 6660taaagattag ctgggtgtgg tggtgcacgc ctatagtcct agctactcag gggctgaggc 6720aggagaattg cttgaacctg ggaggcagag gttgcagtga gccgagattg tgccactgca 6780ctccagcctg ggtgacagag taagactcag tctcaaaaca aaacgaaaca aacaactcaa 6840cctaccatgc gtcatatttc tgcccacagt agaagccctt agagctatcc actttctccc 6900atggggttat cctaactgat gttttccttt cacccagccc tttttcactc ctttacctcc 6960caaacacttc cagtgtcttc tctcaagtgt cctttccatt gcaacactac tcccatgctt 7020tctgagtctc agcctttcct gaaagctggc tgcatcctgg ggacactgac tcttctgctc 7080ccggaggata atgcttattt tgcccctgga ttttccttcg gattcttctc gttctccaat 7140gtttctgcta aatagcactt tgaattcata atgcaaagac ttcatttatt gaaagttcat 7200tctcatggat cctgccccat ctgtcatgcc ttctccaggc tgcattcccc tcttcctcac 7260accaggaaac cacgcactag atcaacatgg ctcccatgtc accaggtccc ctgcctggac 7320cactcatcct cgttacccct ggctggccag tccctgctgc aatgctctct gctgtccact 7380cccgtggttc ttcagcaagc tagtctgtgc cctttcattg cgttttctct gctagattac 7440ctttctgtcc ctgacttcta aatgttaaga gtagttgggt ccaatcccag gtgctccaat 7500ctcatctctc acagtcactt tcggcaaatc ctagggactt aaatgcagct agatgcccat 7560gaatcccaaa ttaatatctc cattccaagc ctctccaaca gcctatccaa catcttctct 7620cagatttcta ttatgtccaa cctcgtgtgt ccaaaataaa tctcttaact ctccctcccc 7680catctcagga gaagaccttg tcatcaccca gcgacagtgc aggacactga aggtcctctc 7740ttcctcccct acccccaaat catcaccaag tgctactgag cctttagaaa ttaaagtcaa 7800ttatttttac actgttaaat atttgataca tacttgtgct acaaaattcg gaaagtccga 7860aaagtaacac gatgaaacgt gagtcctctc cccaacccgt cccttcccca ggaagccagg 7920ttggctcctc gcattgccat atttgtgagg tcacttgcag taggtatctg tgcacatacc 7980cacacgtttt aaaaataaaa aaaatggttg tactatacta tacacactgt tctgaagctt 8040gttttcccac ctcacattat acagtcaaat attattctgg gtcagtataa acagagctgc 8100ctcgtttgtg ttacagttgc atagggttca aacctttgcc attacaagac aatactgtaa 8160tcatgtgtat aagtttctat tcctaacaat aatgcaatga acacccttat aaagaagtca 8220tttcccatcc acatgagtaa ttcctggaaa ttagattgtg ggtcaaggaa catgagacat 8280ttgtcgtttt gacagataca gccaaattgt atagatgctg ttcagtctgt accaccagca 8340gccttgggtg ggaacctgtt tcccaacatt ctggcaaaca caccgtgtta tcaaacttct 8400tgatctgtgc caatctgata ggtgaactat tctaccacat tgtggtttta atttgcattc 8460atcttattac aagaaaggtt aagcaaactt tcacacattt aagcctttct tgcattaatt 8520ttcattattg tgaaatttgt attcaggtca ttcaccaatt tttagaatgt ttttagtttc 8580ttatttttta cagcgctctt ttaaagtatt aaataagcat cattagcact tcatctatga 8640tactggctgc aatttccttc cagcttctac tttaactttg cttttactgt ttttgttttg 8700tttttactgt attcccccta cagaatccta ttttagaaag tcaagtttat caatatttct 8760ttacttttct acttggtttt atggtttcat gttttaatat ttaatttttt gcttcacctg 8820acattttagt gaaaggacac aggcatctaa tttttatgtg tctacaggta tattttctgg 8880ttctgccaac cccatttact gaataatctc ttatcctcca atgaaataaa ctgccagctt 8940tataatatgc tttgtccctt gtatctagat ttagttctgt accaaataca actgaccttt 9000tgatttggct atgttcatgt aggttctcca cctcccactg atttgtgagc ttcctaagca 9060cactgtcagg gtttgagatt ttactccctt tcccttagaa agtaatgtta gcccgtcacc 9120gttaggtgga tgctggcaga ggatgtaagc ctttccggtc agagactcat ggcacagaaa 9180gtggcatgac ttgcctctat tcctcttgct tcccgggcag catggggcaa cagggcgggg 9240cctgttggat gccacgcctg cagtgggctg tgtttcggct gacacaaagg acttgggtaa 9300tccaccattt ttgtagcagg aaataagcag gcccgcactt tgttctggaa tgcgacctca 9360cctcttagtg tggtttgctg caagcacaac ccttaaaaaa ggcttgagta aagcaaagcc 9420agggtcttgc gtatttcact gacccactaa caggcgtggg agcaggagag acgcacagag 9480gagggccttt cccagcagac acagctgagt ggttgtggtc ggtttgcatt ttgatgtcca 9540caggatcagt gtctagtaca aagtaggtgc ttaagaaacg ttgataaatt tgaccgaatc 9600caacatttca ctgggttaga atgaatttac caccacacag cataactaca tcactacatc 9660tattgagtat tattctctac tacacagatg ggtcctcaca ctatggaccc aggcagcgtc 9720aagagtccaa aacggtacct tctaaaggaa gcaacctaaa aataaaagaa atagaattac 9780tgtttgactc attaaaacta atttctgtga aatgaaattt agaaacttcc tcagctcaga 9840gataaaagtc actttctcta ctctacacca ttagtaagaa gaaggtaaaa ttgcagcatt 9900ggacattaaa atcaagcact aagaaagttt ttttaaaaaa gccagatgat ggttataata 9960tatggcaatt tttatcttca aattatgtgt ggcaatattg taacaaaaga cacaagaaaa 10020aaatatttga ggaaagaaat agttgaggaa aatagtgcct tattacttag acagaaagct 10080aatggggcaa agacctatgt tctgggtaat tcttagtata cgtttgaggc ttaacaaata 10140tctagcacat ttttagtaac aatgtttgcg gatttttata ttttgaattg aaaatgccat 10200aaatgcacct tcacgataaa gggtgagccc acttttgtat tattctgtaa ctaaaacatg 10260atgatattta aaacaacaaa gcaaaatgat gatctagata ttaatttcct ttaaagttta 10320tattgtgaga gacaagggtg ccattttgaa attgtggtgt acttttagtg tgaagaaact 10380ttaaaactag gtacaagttt atcaaaataa aacaggtaag tatcaagtct caaaaatatg 10440tatttcattt tctgtgtgct tttagtagca gtgagaatca tgtttttaaa ttctcacttt 10500tactacctaa aaggaaattt ttgtagtata aaatataatt ttaagatgtt ttcaatatat 10560aattcctatt ttttttctct tttagcaaga caaccttggg ctgacattcg aaatttttac 10620taaagaacca gcaagtacta aaatgcaggc tgatgtttac actttcagta gtaattctta 10680gaatgtgttt atctgaactg aaatctctac ttaacagtca gcgggaaatg gcaataaatg 10740gcatctgccc taaatttcac aagttgttgc tttatttatt ttcttgtgaa cctcattaat 10800ccatactccc tcaagtcact ttagtttagt taatattatt tgtgtgacaa aagtgttttg 10860aacaaggaaa aatggaaaat tcatgtataa atagctaatc attggtctta aacatagcat 10920atacacggag gctcagagga caggttggta aagattactc aaaaggagaa ttaaaagacc 10980gctcaattct cagttgtgtc ataatcgtat ctttatggta gctacatatt ataaaatgtt 11040ttttatttat ccctcatact agtaagcgtc aaattcatga tctttgtgag tatactgaca 11100aactactctc acaagctatt actattattg atattttata tatcaacttt ttttcatcca 11160taaaagtacc tcaacgacat gttcagtagc aaataagttt tcagatccct tcactctatt 11220gaataacagc tctgaacact ttgactaact tgaatatctt ctatttgcaa tgcctaaaga 11280ttgagaataa agcagttaag aaggaaggtg taatttgtaa atttagaatt gccaaattag 11340taatgagtat gtaagttcaa ataattttac gcaatcaaaa agatagtgac attcgatgct 11400tattgccatt tgttatttat gtttttaaaa tacatttttg ttatgtgtca ttttcagagt 11460atgttttctt tcctatctta ctttttccaa tttgcttttc aatctttcaa gatgactttg 11520gcttatccta aaaagaatgt gagacttaaa ggtcaatgta ggggagaaat acaattaaaa 11580aacacttggc ttgccagata agcaaatctt gattataact tatttttgat taggtaaaca 11640ttctaaaata atactgaatt tagattcttg tttttatttt gttggctagt attctaaact 11700cttaagtggg cagtgatata catttctatt aaactgtata agtaactatg caaattggga 11760tataaattgc attagaaaat atgaacatat ttgcttgata cttaattcaa ccataaaaaa 11820taaagtattg cacttattaa tgttctcttc cctcatttgt catctgatat tgctcttagt 11880cactcactat caaaatttct ttgtttaatc ttacttctat taatttcctt aaagtttcat 11940gcaaagcaaa tttatgtcag gttgtaagca cctttctctc aaagcaacca ccactgtatt 12000tgtgacaact catgccagaa ccctgaatct gccttgggaa gaaacattgc cagttggtgg 12060cagcattcac aagagagggt cacatttcct ctgttatctt taggttgaat ttcaaaacaa 12120ctctagaaaa cagactcaga gggctagcct tggaaacagc atgcaaacaa ctgcagaaaa 12180gcggaaggtt tctgactata atacagttct accaaacagc agagcatgtg gcaaaaaagc 12240caggctggct cccttcctcc tgtttacctc ctgagcagtg tatgaaacag ggtgagcttg 12300ctcctggaat caataggtga atcaatgaac acaggctggt cttccccact tcataacatc 12360tgtactctgt acaaggacac tccgggccac cctcgctgag catcctcccg ccctctccca 12420gaaaatatag ctgtgtcatc ttacagacat ttttaatgtc atctgcttat gatgtgcaga 12480ttgagaagca gacaattttg ttctgctctg gcatgaaaaa aaaaaaacgt tttaatcggc 12540agctaggata gcaacatgaa gcaacacaca ggacatcaat ttcatcatgc aaaataccgg 12600tgtattatat tacaggggcc aagcattcca aggaaaagta atgatctaag aagatgctct 12660tgcattttaa aaatatctac tagtgttata cagtcattaa tgtataattt ccatttcaat 12720aataggaagc cttctgggaa aaaaagcttg tgttgcttct taaatctaga aacacattct 12780caaaattcaa acagaacaaa atccagaggc atattaataa atattttcaa ctcctaaccg 12840cagtcacttt ttaattgggc atttatgtat ttcttcaaca taattatatt tataatgaaa 12900aaatgttgag aatactggat tagctgcatt tgtaactaca acatattttt ctaaacagta 12960ttaattcaat tgataagact ttaaaaaagt tatagtagtt tgttctatca tatatgcaca 13020ttaaataatc atttatttta gaaaatcctc cctcataaaa tgaacattta ggaaagagac 13080tgatccatat ttttaacaag aataataaac acacaagtag aaagccttta taatttccaa 13140ggggctgatc aattccatta acaaatcctg atactttaaa tgtttgcaat gccatacata 13200gcaaatgatc caaacagcag ttatattctc tcatgtaagt cattctgttg cccatacaca 13260gagttagcat gttacaaaac tcttgtgaaa tttcagttga aacattagca aataaatttg 13320ctggtaaagt gcaagaagtt tccttataaa ccctagatga ggaaaagtct gtccacagtt 13380cgttcatcag aggaatggaa tttctcaaat gagctactga acaacattat ctaataaaat 13440gaaatataat gaaatggtgc cactcatttt aaagattaaa tatatccttt gacagaaacc 13500tgtgaagtta aaaatctttc cctcttaaaa taccttttaa attaaagcta ttctaactag 13560ttatatagca ttccacttaa tctgcttagt ttttagattg agctcaccta aatacaaaat 13620actgtcaaac acctacaggg caaagaacta aaaaaagaaa gaaaatttca caagcaataa 13680aatgctattc acctttctcc tcccatactt gcctttccta tatgaaacaa agaaaataat 13740tagtgatgtt cattattggt agtgctacta gtatttgtat tgtgaacctg taacatattt 13800ttaaatctct acacttttat ataattgatt ctttcttgaa aagtaattat ttcagaagac 13860ttctaataaa ataatcatta ttgtatatga ttctgttaaa aatagaaaaa acaaacaaac 13920agaaaaaact ccctgctgaa agatatggcc attttattag ctgtgaaagg aaagaaagct 13980tccaaggaaa gatcttggac catgagaaaa aatttcaacc aggctgtttg ctggcaagag 14040gccatgccag ccccagccag tcctgcgtgc agagcatgtt ggcagatgtt attagctgac 14100ttttgttgaa aaagtatgga agaacagttg gaaaatcaca aggtgtagaa caagctttaa 14160ataaataaat agcttatctg gcaatagaaa gggggaaaga aaacaagttc ctcggttgag 14220gaagaggact gggatacttc taattacaga gtttcttact gttggtttgt ttcatgggct 14280gactctcaat gagaattgaa attgtatcat ccacatttgt atttggaggt tctaactgca 14340gaattgcaat taatttccag tttgctgtag gaaatttata ctctctatga cagaatacca 14400cggacatagg tgataattct ttaaccttct ctcttttgtc cccagtctgg taactgaggc 14460agtacatggg gaaagtgcta actgccaatc cagagctgct gacaccttaa aaacactggc 14520ctttaacact aggatggccc caagaaacaa gcaaacagga aaagatgaca cctgctagcg 14580tgtgacaggc acagcaagta aatgttcaat acggatatga aaatgcaact gcataataaa 14640agtcaacatg aaaaagaaaa agattgcaaa atatactttc tcagaagaaa ccatcacatg 14700atgtttaaaa gtggtggttc ctttagcatt gtctactgat ggctggcaac atacaggaac 14760atagaggtgg cccatttaca tcctcataaa agtgggatgt aagtgatcac aaagccaata 14820aaactacacc acattttctt caagcaccaa gataagaatc ccttcatctt tcctgactag 14880acatattgct aggcaacatt tgtgaacgta agaaaaggta acaagatcta aaaagaacgc 14940cgaagcataa tgttcataaa ggtggcgccc ccaacacaca caatcataca cacataccta 15000tacacacaca atcacacaat ctattatata aacaaacacg cacacatgca cacataggtg 15060cacagactta aaatggcatt tcttgaggta ttttttttta aggtatgatt taaaaatgga 15120agatcaactt taaacacacc tttttgaggc acactgggtg atatttgcca caatgattat 15180tcttcccaaa ttcaggctac tgatcaataa tcctaactgt atacatgcta aaaataaaaa 15240cgctataatc tttgtactag tcagggctct cttggcacat aaaattagcc aacacaatct 15300tcaagtcaca tgttacaaaa acatattaaa atatatatca ctctttcaaa aattacactt 15360attttctctt agattaagat tttattactt ttaagatact tctatgaatt atagaggaca 15420tccaaaagta aacatccggg acttaaaaac aataaccaat attataagat aaattattgc 15480tgtaaattat ttcatgaagg cacaattaaa aaaaaaataa aataaacagc caaagcctgt 15540tttgttgagt tttcttcgtt gcgcaggatc gggagcttgc tgggatctga actcaggaag 15600ccctcacctc accctgactt ggtcattgag gagacgtaat tgcaggggtg cttatttgct 15660ataggctttg aaagtcacaa aagcccagta gatacatgaa ttcgaagcag ttctccaagg 15720gcatctccaa cttggcagtc accgcccgca ccgcgcacac aggtagtgga cgcccgccca 15780cctgcccgtc tgctgggcgc agggcgctcc tggggtgggg agggcgctcc tgtgggggga 15840aaaggggcgc tcctgcctcg gagggggaaa ggacgcccct gtggaaggaa gggggggctc 15900ttgaagcggt gtggtgagag gacgcttccg aggaaggaag ggggtgctcc tgcagcggtg 15960gggggagagg acgcccctgc ggaaggaagg cggcgctcct gcgggggctg gagagacgcc 16020cgcgcggtct cccggctcag ggaccgctgg ctcgcgggtc cgccctctcc ccggcgctat 16080ggaaaccgca ctttctccgc ctgccgtccc cgatctcttt ctcctattac ctcccaaacg 16140cgatttcaac ttcccgacaa gctgacaagt gaatggcgca gaggacgccc cgtaaagcgc 16200ccgcgagcgg gtgggacaca ggcgccccct ccgcgcccct ctgtcctcca cggaagggcg 16260cgcgccgctc tcgatctgga gcgcggtgct cgcgaacccg cggccgcggg ccctggaacc 16320tccccgcgtt tcgcggctgc ggggggacgg agatgcggcc gggagacggg gacgggaaac 16380gggggacggg gatggggcgc gcccaccccg agcgcgggag cggccgccct cgcccaaaat 16440ggggaccccg cgccccgaga gcacggcccg gctcgccgcc catgcttcca ctgcaaggcc 16500gcagcccccg ccgccgatcc cgatcccccg ccccgcccag ccgcggcccc gcccggcgcc 16560ccctccccgg cggaagctca agcccaatta attgagtccg aggcgggagg gaagggccct 16620gcgcgccgtg gcccgccccg cccctcttcc gcgccccttt tcccgccctg ggtggcatct 16680cctccgccgg catccacaac aagccgctga ttaatgaggc cggggccgcc ccaccccgcc 16740cggccgggcc ggggccttcg cgggaggggg aggggacggc gggaaacgcg gcccggggag 16800aaaggggggc ggggcggggg cgcgcggccc gcccccgcga gcgccgcgcc gattggccga 16860gcgcgccgtc cgtcgggggg cgcggcgcca atgcgaggca gcggggcggg gcggccgcgc 16920tgtgtgtgcc tgcgtaacgc cgagtcacat gttgttttgc tcttcttagt tcagtcactc 16980ggtgcgcgat gtgttactca ctgtgcggcg gggaccgcga cgagcccggg tcgccgttgg 17040cagcagcagc agcaacacca gcagcagcag cagccccggc ggcggcgcgg accccgagcg 17100cccgggcgca ccccggcttc ccggagcgcg acgcggcggc agcagccccg gtgcggccgc 17160gcgcgcctta ggctcggccc cgcggctcgg ggaccccgac tcccggccca gcgagcgcgt 17220cccccggcgc cgcccgagag cccgaggagg cagcggccgc aggcagccgg ggaggggggc 17280ggccaccgcc cgcgccgggc atcctcagga gccccagagc gcggagggcg cggcgccgcc 17340gagcggtgct ggcccccgcg ggcctccccg gaccttcccc accgcctggg cccgagggac 17400gcgtgatcgg gcgggcggcc gggcgcaagg gtgggaggga gccgcccccg cccgcgcccc 17460ctccgcccct cgccccaacc cctgggcgcc gggcccgggc cgcgcggcct gaagcgcccg 17520cgatggcgag cccgccgcgg cacgggccgc ccgggccggc gagcggagac ggccccaacc 17580tcaacaacaa caacaacaac aacaaccaca gcgtgcgcaa gtgcggctac ctgcgcaagc 17640agaagcatgg ccacaagcgc ttcttcgtgc tgcgcggacc cggcgcgggc ggcgacgagg 17700cgacggcggg cggggggtcg gcgccgcaac cgccgcggct cgagtactac gagagcgaga 17760aaaagtggcg gagcaaggca ggcgcgccga aacgggtgat cgctctcgac tgctgcctga 17820acatcaacaa gcgcgccgac gccaagcaca agtacctgat cgccctctac accaaggacg 17880agtacttcgc cgtggccgcc gagaacgagc aggagcagga gggctggtac cgcgcgctca 17940ccgacctggt cagcgagggc cgcgcggccg ccggagacgc gccccccgcc gccgcgcccg 18000ccgcgtcctg cagcgcctcc ctgcccggcg ccctgggcgg ctctgccggc gccgccgggg 18060ccgaggacag ctacgggctg gtggctcccg ccacggccgc ctaccgtgag gtgtggcagg 18120tgaacctgaa gcccaagggt ctgggccaga gcaagaacct gacgggggtg taccgtctgt 18180gcctgtctgc gcgcaccatc ggcttcgtga agctcaactg cgagcagccg tcggtgacgc 18240tgcagctcat gaacatccgc cgctgcggcc actcggacag cttcttcttc atcgaggtgg 18300gccgctcggc cgtcacaggc cccggcgagc tgtggatgca ggcggacgac tcggtggtgg 18360cgcagaacat ccacgagacc atcctggagg ccatgaaggc gctcaaggag ctcttcgagt 18420tccggccgcg cagtaagagc caatcgtcgg ggtcgtcggc cacgcacccc atcagcgtcc 18480ccggcgcgcg ccgccaccac cacctggtca acctgccccc cagccagacg ggcctggtgc 18540gccgctcgcg caccgacagc ctggccgcca ccccgccggc ggccaagtgc agctcgtgcc 18600gggtgcgcac cgccagcgag ggcgacggcg gcgcggcggc gggagcggcg gccgcgggcg 18660ccaggccggt gtcggtggct gggagccccc tgagccccgg gccggtgcgc gcgcccctga 18720gccgctcgca caccctgagc ggcggctgcg gcggccgcgg gagcaaggtg gcgctgctgc 18780cggcaggggg cgcgctgcaa cacagccgct ccatgtccat gcccgtggcg cactcgccgc 18840ccgccgccac cagccccggc tccctgtcgt ccagcagcgg ccacggctcg ggctcctacc 18900cgccgccgcc cggcccgcac ccgcctctgc cgcatccgct gcaccacggc cccggccagc 18960ggccctccag cggcagcgcc tccgcctcgg gctcccccag cgaccccggc ttcatgtccc 19020tggacgagta cggctccagc ccaggcgacc tgcgcgcctt ctgcagccac cgaagcaaca 19080cgcccgagtc catcgcggag acgcccccgg cccgagacgg cggcggcggc ggtgagttct 19140acgggtacat gaccatggac aggcccctga gccactgtgg ccgctcctac cgccgggtct 19200cgggggacgc ggcccaggac ctggaccgag ggctgcgcaa gaggacctac tccctgacca 19260cgccagcccg gcagcggccg gtgccccagc cctcctctgc ctcgctggat gaatacaccc 19320tgatgcgggc caccttctcg ggcagcgcgg gccgcctctg cccgtcctgc cccgcgtcct 19380ctcccaaggt ggcctaccac ccctacccag aggactacgg agacatcgag atcggctccc 19440acaggagctc cagcagcaac ctgggggcag acgacggcta catgcccatg acgcccggcg 19500cggccctcgc gggcagtggg agcggcagct gcaggagcga cgactacatg cccatgagcc 19560ccgccagcgt gtccgccccc aagcagatct tgcagcccag ggccgccgcc gccgccgccg 19620ccgccgtgcc ttctgcgggg cctgcggggc cagcacccac ctctgcggcg ggcaggacat 19680tcccggcgag cgggggcggc tacaaggcca gctcgcccgc cgagagctcc cccgaggaca 19740gtgggtacat gcgcatgtgg tgcggttcca agctgtccat ggagcatgca gatggcaagc 19800tgctgcccaa cggggactac ctcaacgtgt cccccagcga cgcggtcacc acgggcaccc 19860cgcccgactt cttctccgca gccctgcacc ccggcgggga gccgctcagg ggcgttcccg 19920gctgctgcta cagctccttg ccccgctcct acaaggcccc ctacacctgt ggcggggaca 19980gcgaccagta cgtgctcatg agctcccccg tggggcgcat cctggaggag gagcgtctgg 20040agcctcaggc cacgccaggg cccagccagg cggccagcgc cttcggggcc ggccccacgc 20100agccccctca ccctgtagtg ccttcgcccg tgcggcctag cggcggccgc ccggagggct 20160tcttgggcca gcgcggccgg gcggtgaggc ccacgcgcct gtccctggag gggctgccca 20220gcctgcccag catgcacgag tacccactgc caccggagcc caagagcccc ggcgagtaca 20280tcaacatcga ctttggcgag cccggggccc gcctgtcgcc gcccgcgcct cccctgctgg 20340cgtcggcggc ctcgtcctcc tcgctcttgt ccgccagcag

cccggcctcg tcgctgggct 20400caggcacccc gggcaccagc agcgacagcc ggcagcggtc tccgctctcc gactacatga 20460acctcgactt cagctccccc aagtctccta agccgggcgc cccgagcggc caccccgtgg 20520gctccttgga cggcctcctg tcccccgagg cctcctcccc gtatccgccg ttgcccccgc 20580gtccgtccgc gtccccgtcg tcgtctctgc agccgccgcc accgccgccg gccccggggg 20640agctgtaccg cctgcccccc gcctcggccg ttgccaccgc ccagggcccg ggcgccgcct 20700catcgttgtc ctcggacacc ggggacaatg gtgactacac cgagatggct tttggtgtgg 20760ccgccacccc gccgcaacct atcgcggccc ccccgaagcc agaagctgcc cgcgtggcca 20820gcccgacgtc gggcgtgaag aggctgagcc tcatggagca ggtgtcggga gtcgaggcct 20880tcctgcaggc cagccagccc ccggaccccc accgcggcgc caaggtcatc cgcgcagacc 20940cgcagggggg ccgccgccgc cacagttccg agaccttctc ctccaccacg acggtcaccc 21000ccgtgtcccc gtccttcgcc cacaacccca agcgccacaa ctcggcctcc gtggaaaatg 21060tctctctcag gaaaagcagc gagggcggcg tgggtgtcgg ccctggaggg ggcgacgagc 21120cgcccacctc cccacgacag ttgcagccgg cgcccccttt ggcaccgcag ggccggccgt 21180ggaccccggg tcagcccggg ggcttggtcg gttgtcctgg gagcggtgga tcgcccatgc 21240gcagagagac ctctgccggc ttccagaatg gtctcaacta catcgccatc gacgtgaggg 21300aggagcccgg gctgccaccc cagccgcagc cgccgccgcc gccgcttcct cagccgggag 21360acaagagctc ctggggccgg acccgaagcc tcgggggtct catcagcgct gtgggcgtcg 21420gcagcaccgg cggcgggtgc ggggggccgg gtcccggtgc cctgccccct gccaacacct 21480acgccagcat tgacttcttg tcccaccact tgaaggaggc caccatcgtg aaaggtgagg 21540aggccctttg ccttggcgtc tggcgggaag gaggggcggg gcgctgaggg agcctcttgg 21600gtttcactgc tcccactttt tggggacctt gacccagaag ccgacagcct ggcactggct 21660ccttgttttg tttttctgcg ggctgccctg ttctcttcct tcagagaact tgccaggaac 21720attcgtcttg gagttgaatg tgacgttttc cgcgtgggag ggagactgat tttttgaggc 21780cccacccatt cacccattct gtgcgtccca cagccccctg tcccttaaca cagtggaagt 21840tctcccagac cggccacact agaggccgcg gggcacccga ctgtcttcat ccggctgcgt 21900gggtccgtcc ttctggaagg acctcgggtc cggaccgctg ccctcagccg cagctttcac 21960ctttccctgt gttcctggag ctgggctccg cctgattctt ggtgagcttg aaggttcaga 22020cctgaaagtc atttaagaaa tgagcatcca ttttgatggc tgctaatagc gacagttaac 22080catttccgtt ttacacacaa actgtgggag cttttccatc agaggcattg tttttctcgg 22140aaggggtgaa acggtaaggc tgcacacagc ctaatgcagt ggtgttcaac ttgagcatat 22200gtgggagtta cctggaggct ttgctgaaac atggatctct ggcctgtgtt aaccccgcag 22260tttccgatgc tgtagctttg gggcgcggcc caggctgtgc atttctagtg agtctccgca 22320taatgccgat gctgctggcc gggggaccac cctgtgagga ccctgcccca ggtgagactc 22380acctggggag gattgaaaaa ttacctgttg ggcctcaccc cagacccgtt gaagtgaaac 22440atgagatggc taggaggcag ggacggacat ttttcagagt tgtccaggtg atttgaatgt 22500gcagccagga tttacaatca gtgctttgga gaaaacaagg gaaagacaaa aaacacaggt 22560cttctcaaga acaattggat aggagggtgc ctggtattgt tcttcccgtt ctgatcaaat 22620atccatgagg agagagagct gatgcagaat gcagctggtg gtgcattctg gctgtctaaa 22680ctttgaatgg tgtttggggt cggggagatg agagggaaag gtgaatgctc aattcgggag 22740actttattta attttgtagc tgttttcttt gtagggttcc tagcaggata gaggctttgt 22800gggaacagtg aaacatatag taaaatttgg atgctggatt agatgtgagc ctaaggtgta 22860aacagtcttc aagggtcatg agatgaggat caaggtgggc tggagattca cagccttttg 22920ttcttaaata gaccagttta gtgctatcta aatccagcat ctgttttata gtatacttag 22980gactgtcggt ccatgggatt taaaattata gctgtggggt gaactccctg ttattctagt 23040gtaatagaga aaagctattt cctttattaa aaccgtatac tagaagatga agagtcacag 23100agaattatca ggagtgtggt gcttcagcat ccaattaaat cattggaagt cgccagaatg 23160tatcctgtga acagtgattc tcagctgaag gtcactttgg ttggagttac ttatacacta 23220ttgctagtgt gtcagaaagt tgaaggatta gctgccttat aagacacaga ccattataaa 23280cacagcagca gcagcagcag tataattgag tggggaaaaa cacacatatt tatggtctgc 23340acaaatgggt atatgccaga gtgaacatga aagtaaatta catcttaccc gaatctgatt 23400ctaatcagaa aacagccaag aacataacac cttttcctgc tttcagtgga gctggtggga 23460caaacctgga ctgggtggag ctggggcccc agcagtgggc tctgccatag caggcgccat 23520aagctggaat ttgtgcctcc aggcctggag ggacgcaagg cgtttctgat gaagccgata 23580cattcagaat tggggtccaa ataggaaata atgccctttt caggctagtg aaaatgttga 23640actctaagag ataagtttat ttagagactg gattgagctt ttgtttaaga tttcccacct 23700gcgtaaaatt cctttcagcc cataggattc ttgattctga agtccagaca gaagcctgtg 23760ttctgtagct gctgaacaaa gatgagagat cactggggct gctgtttgtc cgaagtttgt 23820gtgggtatca tgatgaaccc tcttctaaga agtaaaagga tcttttaaat caaaatagac 23880aactgcagtc agtccaccat gcccaacgac atttaaaaaa aaagaaatat ctgccccatt 23940gggtttctag taaagtaagt tgaacacaga gaacagcaga ataggaaagg ctagtgtcac 24000cttagtccac gtagcaccaa agttgtggtc cgttgagaca gaaaggaagc atttaggaac 24060ttgggataaa tacccacttt tatttaactc atacatgcac tagaaatttg tttgggatgc 24120tcataaatac agagttcaca gtagatcagt gtcctttgag gaaatgattt gtagaaggcc 24180gacttgcaaa gcatttcttt gaagatgaaa tagagaaagc acttcctggg cggccccctg 24240ccctgcctgg ctcttagaag tggcctgtgt ttccaccctg agctcttcct gttctgcatg 24300ggaagacctc gttagtgatg ctgatgcaga ataattttgg ggttatgtgg gtaatgtttg 24360gtatttgcat aagtgatagc agagaggtaa ggttccagcc atgtctggca cttgtttaca 24420atagaatcgt gaatgggggt gggctttcag tgcaagagcc agttaaaaag tatatctcag 24480gtacatctgt ttttattagt ccagagcaaa ctcaaaatta tgcatcttat ttgagggcag 24540gttaaggtta cttatcatgt gtttttggtg tgtgtgcatg tggaaaactc taaccaattt 24600gttaggtttc gttgttgttt gggaattgga aagacgctac tgaatttcct gtgctttaaa 24660actgattttt aaaattaact ttatatgttt ttgtgttagg atggtagatt gatgaatgcc 24720ataaaatttg ctgttttagt attccttttt agtgatttta gggattttat tctaaaattg 24780gcgtatatat atgtatgtat gtataagaca gattagatca gaattactac tgaaagtatc 24840catatttaaa ttttgttgaa taaaaggatt atcatttctt aaggggaaag aatgataaga 24900gatatgtttc caaagggaca ataaaatcac gatttatgtt gaaaagtttt gccttttgaa 24960gtcgtaaagc agagaatttt cctaaattca gaaatccagt gaggtgattg acaaaccaca 25020caagttttct gtttgctgtg gcgggtgcta gtttgcttta gttggctggc tctggccata 25080ataagacaat agcgtgcact gctgctgccc tattcgcagg agcagacaac taaggtgcta 25140atgaaaacac acaccggctt tcgtgaatga aagtcacatg acttgttctg tttcctttat 25200tgaaagagaa acctttacaa aaatagtact tcatagaagg aagcatagta tgtggaacac 25260taaaccagga atcaggaaac caggtttcta gttgctgatc ttaatgagtc attgtgtgtc 25320tatgggagag ccacttaatc ctgccttctc actttccctg tctgtaaaat gggggtaatt 25380ataatcctcc cctttctgtg tcacaaggcc gctggaaggt aaatgaggtc ataaacatca 25440agagtgtttt aagctcttct aaaggaagat gctaataaat ccagttgttg atacttattg 25500ctttgaaacc atgaatgtat acaggaaaga cacttttgta aatgggtgct cttaaattga 25560aacaaacagt aacagcatag tctgaaaatg gagccagcac cttaaaaatt gcttaccttt 25620actgcttatt gctagttccg ctccaggctc ccaagagcca ttgttttccc cctttatgta 25680acttaagatc tgttcataga tatttatgaa cagattgtaa caaagtggtg ttctaaatta 25740catagtaaag taacaattag ggaaaacagt atggtaatcc tgaaactatg ttaagactga 25800acttctgatt accttttatt actggttttt atattaagag atgttgacaa gatgaaaatg 25860tataattaga atatacattt taaaaatcgc ctcttaatgc cgaatgcatt gaaagaaaaa 25920cagaaccctg aggttgtttg actactcatt gtttagtctg ggggttcatt ctttggggtc 25980gatttaatga gggtggtcat tcctgcagtt ttgatggtag cactgtgctt atcaaacata 26040gtaggaaaat gcgtgattct tttgtttttc taccacccaa aaaggaatct tagtagagaa 26100ttgatatttt attttcttta gaagtatgag tatttaaaat gaggctcttt tttctgaaga 26160gaagaacttg gaaaagtttt agtaacagca tgagtataat gggttttctg ttaaaattcc 26220cactaatgca ttttctttag aaacgtagtt ctaagagcta attttggtat cagatttggc 26280aagtagaaag ggtttttgtt tgtttgtttt ggtttttttc tagggggagt agcacagaat 26340caagtgttcc catttcacct tataaactta agggaaaatg taactttatt ctttcatctg 26400cattgccaag tagaatgagg aaaacactgg gtgaggcaaa gtgctgtgcc ccccgccccc 26460catcctgcat ttggacagct gtaatgcagg tggattctct gtttcatttc tctagtacgg 26520atgacagcag aatgtatatt tctatacaag atgaacaaaa cgttttaatg ttggcgtttt 26580aatgaacaaa tgaaaacaaa attttctgaa tgtccaaaag tattggttat aaacacatta 26640actgtcagat catgattttt gtgaaaagaa tgctgtccaa gtttagatag ggacactctt 26700tctatattta gtttgagtgg gttcttcaag actgcagtgg ttattctgac tcatttcagg 26760tagattattg tacacagagt tcagtgctag acttttctga agaaaactag taaagtcatc 26820atttggcatg gaggagatga tggggttgat gattgctact gatttcaatt tctttcaaga 26880tagctacaga gacttacatt aactgggtgc taaaatacaa tgcataggtg aaggttagtg 26940tagaaagagt tggagtatat gttgtatacc aacattttgc tctgtaggtg caaataatgc 27000aagatgcttc tgtgtgttat agctttatta cttaagtgaa ttcattacat aagaattctg 27060aaatagattg gattaaaact tatgggttac atgtttacaa atgataaaat agtcaatttg 27120gtggttctga ttaattttct attagactag gaaaatacta agtttgtata gagtcacttt 27180tatgtgtcca aagacactgt aaaacttgaa tgggtaaagg tgaagccttg gaaactctgt 27240ccagttttct tatgtcatat atgatatcta tatacacaag gtttataaaa tattccttgc 27300ttactgtgtt tttactgaaa tttggaatat ttgatcaaat attttgaccc acgatatatt 27360ttttaaagat aactgatcac acgcattgca ccctgtaaat gctgggtttt tttctttttt 27420tttttttgag acggagtctc actctatcac tcagtctgga gtgcagtggt gtgatctcgg 27480ctcactgcaa cgtccacctc ccgggttcaa gcgattctcc tgcctccgcc tcctgagtag 27540ctgggactag aggtgcatgc caccatgccc tgctaatttt ttgtattttt agtagagatg 27600ggatttcacc gtgttagcca ggctggtctc gatctcctga ccccgtgatc ttcccgcctc 27660agcctctcaa agtgctggga ttgcaggcat aagccactgc gcccggccta atgctggatc 27720ttttaatatt cattttaaag agtatcaggt tttccagcaa caaatatttg gggctggtgt 27780gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtttccataa tatctcatcc 27840agtcatgctc caggaggctg gatatgatat ttttctccat aactgaaatt caaggattaa 27900tgatgtgttc tttgttcatg ttgaaacttt ataacttaag catagtctac tgctacttta 27960tccctataca gttagtacaa atacttgagt cagttattac ggtgtggtat gaaatttcaa 28020ttgttttcaa tgcataaaaa cagatattat gatatagttc attatactat gtgattttgt 28080tactttacaa tcctattata ctgtgtgatt ttgttacctt aaaatcctta tgtttatgtt 28140aagaatgatt cattcttgga tgagcttggt ggctcatgcc tgtaatccca gcgctttggg 28200aggccgaggt gggtggatca tctgaggtca ggagttcaag accagcctgg ccaacatgga 28260gaaaccccat ctctactaaa aatacaaaaa ttagccagcc atggtagcat gcacctgtag 28320tcccagctac tcaggaggct gaggcaggag aatcacttga accagggagg cagaggttgc 28380agtgagctga gatcgcgaca ctgtactcca gcctgagcaa caaagagtga aattcagtct 28440caaaaaaaaa aaaaaaaaaa agaaagattt tgcatagtat taatgcttaa tctttaatat 28500ttaagaatat gatacagtgc tttctgtatg cattctatgg acttaaataa gtcaatcttt 28560ggcctccaaa gtataagtgt aacagataat cccacaactt ggtagacaac tggcaactga 28620agattttgaa agaatcttat tgaagttgaa tgcaatgacg atgtaccatt attctgatca 28680atattgacgg ataactgcct gccactcttc tcttggggtt aaaagagttg tgtaaaattc 28740aaagggtgtt tttcttccct ttatagtggt aagacatttt cctatataca atatggtata 28800atattccaaa aaatcctatg gcataggcag aaccaccatg aaccccattc tttggaatca 28860agaacctaca gtgtggagag gccagatgac ttgctccaga tctctgagcc aaaaggagaa 28920ggagtgtcgg gttcaacctc ataacatctt ggtatcccta gcccagttct ctaatgtcat 28980attgtctgct tgggaagctc atatgcaata attacattag gattttatcc tagacccttg 29040cctcaagcaa catttaagtt aatattttgc tggagtgata gttaatcatc tccccctttt 29100tcttccactg ggtatcaatt caaaggaaaa tggggaccat tgaggaggaa gactggtagg 29160aaagcgctct atttattgaa atcagttttt acatcctccg gtttggagag tttagtattt 29220gatactattt tcaaggctgt gatgttacta gtgaatttta aagttgacca tcaagttggt 29280gatggatctg ttctggggac tccagtcatg cttcctggac ctctagatgt gtcaacaaag 29340tggaaaactt agattgctct ggctgtcttt cattacctct tggtaaagca aactgtatat 29400gatacttggt aagatacctc cccaccaccg ccaccatcaa atacattaaa actcttgcaa 29460ctcaggtggt gacaatacga aaaaaatata caagggtgtt ctgagaagga agagttgaga 29520accgttgata gaatgtaact tagttattta aggttgtgaa aacagaggct gtgtgaggtc 29580cggagtctta gtcaaggtca ctgattcaat tagtggtaga gttgtttgta gatatcatca 29640agaaagagta ggagaatgtg atacaaacaa tgacacatct cagttggttc tttgtatctt 29700gatgaataac tttctcccag gatacagcct atgctcttta gaacaactta gtatttgtgg 29760aaatgatatt agtcttttta ctttggaaca ttttagtaac tttcttcatc catagactaa 29820aagaaaccct gaaagccaga aatagagaat gcagaattcc ttaatgaaga aacgcgttat 29880aaatcagaga aatatggctg ttcatgacta tgtggacggt gtctactgag tggggagaag 29940atttggcaaa tatttaaggt catgtattta ctttatcaaa gaaaaggaaa caaagttatt 30000gtttcatgaa gacccccagt gaaatcgaaa ggcctagatt atctagcaga attgaaggcg 30060gctctgtgta acaggttcag cctgggcggt gacacagtga tgagtcagcg ggtgcattcg 30120gtcactgctc tctgtgtctc taagacaggt gcttgttcta taagtgaaat atcatatatt 30180ccccattatg gataagtcca ttaacatttt tctaagaaat gagtcattaa cctatttaat 30240gagtttattt gaaaactaat caatttagaa tttgcctaag gaccaataac taactaatca 30300gttgttgcta ggtggttatc ttctggggaa ttgagtattt tgtcagtgcc tttttatttt 30360taacagccct tgtttttttc ttttttttta attctcagga aaaaaatcat ttagctggat 30420ttttatatga agataaatag ttttcataca aatttaattt cacagaagct gccattattc 30480taatgacgtg ggtataacct cactttcaaa agcagaaaga aacactttag caaacacata 30540aaaattctta agatattcac actttaaaaa atgtaatagg cggccgggcg cggtggctca 30600cgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcatgaggt caggagatcg 30660agaccatcct ggctaacaag gtgaaacccc gtctctacta aaaatacaaa aaattagccg 30720ggtgcggtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatggcg 30780tgaacccggg aagcggagct tgcagtgagc cgagatcgcg ccactgcagt ccgcagtccg 30840gcctggccga cagagcgaga ctccgtctca aaaaaaaaaa aaaaaaatgt aataggcaaa 30900tctgtggcct ggaactcttg tgggcagtgc agtgtttgct ttgtgcaagc tgtcaggcct 30960ctcagcatca agagacagta cctccttcct ggccagcacc cccaacggtg agcgccgtga 31020cccaccaaac agcaggtgag attggagacc tggctggatg agcaaagcag gaaagcagtt 31080ttgctatccg ggcgaatgga gttacggacc ttcttccagg ttaagaagaa agccacgttc 31140ggagcgccct gtgttgcagt gatgggtttg ttgagcaccc accaatttag tcaggaaaac 31200tgatgcagac gtgtggtctg ggggtcttca tgaatcggcc agaagccttt tccccagcaa 31260ggtttgggtg cctctgggaa cttttgcctt ctgcagagga cctgggaaga gcgtgcacct 31320acctgcaccg ctccgtgcta tgaaccaccg aaaataggga ctgaagtcag ggaccatctg 31380accacgtgaa ttcccgggtc tgcggcagaa gccgcccccg atcccgtcat ctcagtggcc 31440accctcaccc atgactgccc tgcgctgcct gggcccagcg catgccgggt gagcctctct 31500gccctccttt ctttgttcgg gacttcccat acccagatgg atggataaat aaggggaatt 31560gtgaagcagg gagaaaagtt ttggaaatag gccagaattt ctttactaaa tttaaaaacc 31620atgcacataa tcctttagaa actccacgca ataagcagga ttaagcaagt cgtggattag 31680agtgtattga gcagagactg tttctgtttg aagaggtcag aaatggaggt actgggaccc 31740tagtttactg tggacattgc agggcttctg aacttcccag acagcagaaa ttcctggaaa 31800agtagagtct tgtggtcagt ttcttacccc acacctttgg tgcattttaa aaaaataaat 31860tactaaagtg ctttgcttca gttttattct ggtatgatag taggtattca ctttttattg 31920tcttcctgca taaaagcaac ctaaaataac gttttacata cgcaaatgaa acagaaaaca 31980aatccataag ctacccatac cctcttccag ttctatatat caggtgagtg tgctgagact 32040tgtacaaata acttatgttg tcaagtagac atctactaaa tgtatagttc aactgaaagt 32100atatttgagt atgctttagc aaaatgtgtt agttgcaaaa gtaccaaatc tctttttctc 32160ttttaaagta ttataaatcc aggattgtaa atttatttta attgcagttt cagaaaacta 32220actttaattt agctggctga gaaagcaaaa gagaaaaaaa ttaaatatta atattgaact 32280gcatgaaaat actagataca aaggctacac aaaacccttt tagatataaa catccatgaa 32340tttgcattca ttgatgcaaa gacattgttg agattatttg ttctgacaag ttttttaaat 32400gagaatttct cctaaaggtt ttgtagcttc tacatgtaag ggcattttgg tgtttgggga 32460cagatgaaag tttcagtggt ccagtagaaa ggacacacct tggttcagtt tgccgtctta 32520ctgttatttg cagcttagct tatcagtgtt cctagttcga gatgaaataa tcactgcaat 32580gaaatgtcca agttttccca gcagggagca tttaatgaag ttcttagaac aagtctgggt 32640gatacacatt catctgtgtg agtcttgatc tgtccaggtt cgctgggctg tttagaatca 32700ctgggtcttc agccatttcc aaaacgcaga acacagttga tattttaagc caatcaatgt 32760attgagagtt cagcgtgtgt cagcacaaga gtagatgtcc tgggagatgc agaagaaatg 32820tgaagcctgg cctctgttcc ctaggtgcct tcagagtcaa cttggcagca tcccaccggg 32880caccattttc tgggcagccc ctctgatcct tttcataagt gtccaccccg caggcaatct 32940tggctgagca cagagaatgg gatgtttcac gggatgtctc tgctgcgaca gtggatatcc 33000ttgctggaac attcacagta ctggtcccat tcacagctgg gaccactcag atgtttcacc 33060ccttcacccc tgcgtgaacc tggggtgcat cagatgaggt agtgtttgta agttttcttc 33120tctgaaaaat agtagctttg attctgctgc tatcccgatt cctagatgtc agcttgccct 33180gagctcttgg cggccttgcc tccaagctct cctggtactt cattctgtgc tcagtctttg 33240ttgtaaatgg tagtattcca gaaacttccc cattgtcagg tttcttggct cctttttgta 33300ggcagcccca aaggctgcgt taagggtatt gatcacattc tttctatagg catccctagc 33360ctgttcagga aagccccctc ctttcctgcc agccacagcc cccaccggct caaagggctg 33420cttgccgctc ttggcctccc tgccctccat ggtggtggcc agtgtaggcg aaagaaggaa 33480gtcccattgg gttggggagc tccaagtcac ccacccgtga ggctgatggg ggagttagtc 33540acagatgagt ctcctcccat tctcaccttt tgccaccttt tgcagttttc agaaaaaaag 33600aaaaatagga actttactta tgggttgctt gagaaaggta gaaagttggg ggcagaaagg 33660acgatggcaa aaatggtgag atctcccttt aatttttaaa tgtattcaaa ctgttaaatt 33720tctgcatgtt ttcattacaa agatgacaat tgttgcatat agactatctc aaaaatactt 33780catccatttg agcaatatga aagaataggc tagagagaaa cagatttggt ttttcaagct 33840aaaaagaata acagaaagtg ggcgagtctt cagtgagctg tctgcctttg aaacctagga 33900agtaaactta atttggatgt gcatttagga gatgaagcac tacaggtggt gaaatgctct 33960agcaatgaag cagggaaggg agagggggga aaggaaattt gagccaagca acctgaaggt 34020caggggaagc cggtcttaca gatgttaagg gaggaatcca agtaggcaaa ggggatgaac 34080agcagtgcaa aggctctggg gcagcaggtt gcccggtatg ttccagaaca ggaaggaggc 34140cagtgtggct ggcatggaga gctaaggctc aaaggagaaa gtgaagagaa agaggtagta 34200agggaccagg aggaattgag cccggccagc cgtgctactg atgttagccc acatgtcaca 34260gtgtgtgagg gagatagagt ccttgggaac aataatatgc agagctttta aaaactttca 34320tactgtagcc atcaattcca tcatcatggt ggtggtatcc ctgggtggtg gtggttactt 34380ggtagagtat acgtcaactc gaatttcttc ctcaaaagta tataaaattt gaaaagacct 34440agaagtgatc tagtggaatg aagacgctga ggtaccattg aggttgggga aactactggg 34500acgtgcttac aggataaact gcaaaacaaa agcacaagtt tgtaatcatg gaatgacatg 34560ccttattctg aaaacttaac gtttgtagcg taccttataa ttcataagac atttaaaaat 34620ggtattgaat cccaataacc tatgcgtagg gttggatctt gttgttatcc ctgtttttta 34680atggaaaatc tgaggcctga agatggtagg ccatgtatat gcctgccccg ccgttgagcc 34740tggctcctgc tgttggagaa actttcccag tctgtagaga gaggatgtgg tcctggcaag 34800cctggctcct gcctgattct gtatcttctg gtaacacaca gccgtcattt aaaaaaaaaa 34860agacaaggtc tttccctctg acagactaaa agctgaatcc gcttatttcg aactctgcct 34920tgaggcggga tgccccgtgc attatggtta actaggacct gctaaccatc ggcttatcaa 34980acaaatcaat ttcactcttc agctaatttg gaaatgaaaa ttatagaagt tagaaaaaat 35040gtgcagaaaa agtattattc caatgtatta ttccatttgt ttcatagaga tcctggcttc 35100acaggaaaga gccaagggca tgggttttgc tgagggcgta agagcttggg gaaggtgagg 35160gctaggtgtg tacgggtgcc ctgatgtcct cttagcctgc tggtgaggaa agtgcatgtt 35220taataaatgg gctccagcca actgtgtgca gttatttgta gcctgcataa ttttaaaaat 35280gtggttgagc atttaggtct atcttcagaa tttaggctcc atttgactta gttttcctga 35340aatatgtaga aaactaatgg tgaaagagga cctaattctt gaattatctg cttgaactgt 35400gttgctagtt attccaagta gaatttgtaa aatggtccat

cattctctaa gcaaaatgag 35460ggaaataaca attattttct agaaatttca tatatattga atattacaaa atcatgtaac 35520tagaaatgtt taaatggtca cactgggcca ggcacggtgg ctcacgcctg tgatcccagc 35580actttgggag accaaggctg gtggattaca agatcaggag tttgagacca tcctggccaa 35640tatgatgaaa ccctatctct actaaaaata gaaaaattag ctaggtgtgg tggcgcatgc 35700ctgtagtccc agctgcttag gaggctgagg caggagaatc gctggaaccc gtgaagcgga 35760ggttgcagcg agccgagatt gcaccactgc gctccagcct gggcaacaga gcgagactcc 35820atctcaaaaa aaaaaaaaaa aaaaaaagga aaaatggtcg agctgatttt ccagaatgga 35880atatcactgc gtgatgctct ctgggaagag aaggcattaa gtctgtaaca cacaggacag 35940aactactgtc tattctgtac gcatctgctt gatcctcagt tttgtcacct tggttactaa 36000caaggtggtt agaaagttac atctctcttg aatccattct taaaggcctt caaggactca 36060ggcacagcct tgggaaacca ggaaatgtga ctgtgtcaat caccacacag tccaacttcc 36120ttttcgtgta ggaaatgttt tctttatcat taattgatca gttctcccct ttccaaactt 36180ctggcaattt gggaaatgga atctttatgt tgctgggtat tttctccttc cacacctcct 36240tctccttgct ggacaggagg ggagggcaga agacgtgttt gtggccacat tcccggtgtg 36300gcccgcctgg acaggagcca gggtgcacac tgacctgcac agcctctggc ctctgtccct 36360gggcctgaga ggcaggagca aggggcctgt cctcactctg aatccaactg ctggtgactc 36420agggcaccct gctggaccct ccaggagaag ttggggccca cgtttctagg ctgcccactc 36480atccaaacct ccctccatgt ccctgaccaa agcatttcgc agatctgggt cctctggtgt 36540gtgaggctcc tcccagccca tgagcattgg aaaatgtcta caagatcttt gccattttag 36600gttctaccga ggctaaagaa tgtatgtttc ctctgcttag acttaagttt ttgagtaact 36660ttatagacac tttggcattt tggctgaaag ggcatgtgca gtaactgaat atgacttgtg 36720cactgtttca gtgccagtgg gtcacatgca ggggagtcag agccaaggtg gatgaggctg 36780ggatatctac atgcttggtg gggagttgga gtcagggtgg atgaggctgg gatatctaca 36840tgcttggtgg ggagtcggag ccagggtgga tgaggctggg atatctacat gtttggtggg 36900gagttggagt cagggtggat gaggctggga tatctacatg cttggtgggg agtcggagcc 36960agggtggatg aggctgggat atctacatgc ttggtgggga gttggagcca aggtggatga 37020ggctgggata tctacatgct tggtggggag tcggagtcag ggtggatgag gctgggatat 37080ctacatgctt ggtggggagt cggagccagg gtggatgagg ctgggatatc tacatgcttg 37140gtggggagtc ggagtcaggg tggttgaggc tgggatatct acatgcttgg tggggagtcg 37200gagtcagggt ggttgaggct gggatatcta catgcttggt ggggagttgg agtcagggtg 37260gatgaggctg ggatatctac atgcttggtg gggagtcgga gccagggtgg atgaggctgg 37320gatatctaca tgtttggtgg ggagttggag tcagggtgga tgaggctggg atatctacat 37380gcttggtggg gagtcggagt cagggtggtt gaggctggga tatctacatg cttggtgggg 37440agtcggagcc aaggtggatg aggctgggat atctacatgc ttggtgggga gttggagtca 37500gggtggatga ggctgggata tctacatgct tggtggggag tcggagccag ggtggatgag 37560gctgggatat ctacatgctt ggtggggagt cggagccagg gtggatgagg ctgggatatc 37620tacatgcttg gtggggagga ggagccaagg tggatgaggc tgggatatct acatgcttgg 37680tggggagttg gagccaaggt ggatgaggct gggatatcta catgcttggt ggggagttgg 37740agtcagggtg gatgaggctg ggatatctac atgcttggtg gggagtcgga gtcagggtgg 37800ttgaggctgg gatatctaca tgcttggtgg ggaggaggag ccaaagtgga tgaggctggg 37860atatctacat gcttggtggg gagttggagc caaggtggag gaggctggga tatctacatg 37920cttggtgggg agttggagtc agggtggatg aggctgggat atctacatgc ttggtgggga 37980gttggatcca aggtggatga ggctgggata tctacatgct tggtggggag ttggagtcag 38040ggtggttgag gctgggatat ctacatgctt ggtggggagt tggagtcagg gtggatgagg 38100ctgggatatc tacatgcttg gtggggagtt ggagtcaggg tggttgaggc tgggatatct 38160acatgcttgt tggggaagag gagccaaaga tgtggatttc ctctgtctcc acatccttgg 38220gcaaggactg gtgatcagct gctgctgtct tattttattt gcttctccag taaatgaact 38280ttatatagtt ggtagcttgg cgttttccat tttgcattac tgaaatttca ataaatagtg 38340ctttagttag atgtaaatct ctgtcatttg tggcagagga acttaaatgt cggcctgcat 38400tttagggcac ctttttgtat agagcagaga gaagggaagt gctgtccccc agtggcctgg 38460accaggcgga gcccagcctg ttgatgatgc attgtgtgtg cttggcatgt gtgacgtggc 38520aagggattca tgttctctgt gggcagctgc ctgagtagta gacatgtgag gccccttccc 38580gggcattttg tcctgtcctc aggacatgaa gaaagcagct aggcaaaggc actctttgca 38640gctttaaatg gcctagagtt acccccagaa aaacaattct acttctgttc cacttctgtc 38700caattaaaac aagtttgttc attttatttt aggagcaatt tgccattgtt tttgtgcatt 38760cggcagttgt ttatttgctg cttgcagttg tggttgttcg tggtatcatt cacgaataca 38820attttgaacg aggaagagct gtgatgacaa atgcactaag agacaccact gtggctctcc 38880acaaattagc cagaacataa gggtgggagg agcctgtctt tccctggcag cacagggctg 38940cctggtctta agaagtctgt agttgagaac acagcatgtg gttacatgta tacattattt 39000gaaggtgcac aaagcaaagg gaagccaacc acaaaatgcc agttgtgcta gtagcatgtg 39060cttctttatg aatgaaagaa catacgcatt tttggtatta attatttata tattttatac 39120atgaaatctc atttgacagg ttccctgtga ctccactggg gaattcaggg tgggagaggt 39180agtgccccca tcttcataag agggagcaga cttagagaca tagctgtaga gattacacag 39240ctggtaagaa gtggttccta gatgctagcc ctggggaccc ggctctggtg tggcgacagc 39300gcctttcaca cctgtatcct gagagtcgtg ggaatggcat gtagtttaaa gtacagagat 39360gggggcatgg agtcattcct aggctcccag ggaagagcag gatgtttttg atatggccga 39420ttaggaagaa tgggcacttt gatctctgca aagagagcct gcgcttcagt gactaagtag 39480gatttgaccc ttcaaccttg actctagtag atggctcagt taaaggctac gtggtgattc 39540ttaggaggct tttaaattag atagatggat ttgtccctgg agagacaaag ctgaaatcct 39600atatcacata gatgttatag accgaggagg ggggatttac ctacagttat ttaagctttt 39660aaagtagaaa aaaggtccag ttgaaatgat atataacaac aggctatctg gagatggata 39720tattgtgaat aaataattat tctacattct cttaatttgg cagcaaaaat ataattaggt 39780tttataattt ctgatataaa caatataaac attgttatgg tgtacataaa atttttttag 39840attagtaaga aaaccatacg tataaacatg tgttaagtct gaggaaagaa ttacgtcgtt 39900cattggctat ttgcgatttt aatgcacctt atatcacttg gcccaaatac tcttagggca 39960gaagcataat gcttacattc acattctcaa atgacccaag aaagagaaaa gatttggacc 40020cttaatgagt tgtagatctc atatataaac ctttacttct gttaaaggaa gaatgctagt 40080gtaggatgta tttagcaatg attagattta ttgagcactt ttgtgttatg catgaaaaat 40140caaatagaat agcggtagct aagagaaatt cattccaaaa gtgtgctggc ttcataaatg 40200attttgtgat gtgtgtcctc tttttcagta gggtctgtaa caggatagtg tggtttttag 40260tagatagtat tgcatttcta aagtacgtaa gcttgcagat aattttcaaa gggatatcaa 40320ttagtttccc agtataacac acagatggaa atatatggtg tttttctgac aaatttgcct 40380gtttttcttc gcattgtctt ccttagtaaa ggttgccatg ttcatgtgct ccttgaagga 40440ttaacaaaca ttctgtgaaa ggtcaggtag taaagagttt aggttcattg ccatgcagtc 40500tctgtcacag ctgctccact ctgcttatgg tgtgaaagca gccatatgta aatgcgtgag 40560cacggctgtg cccaaataaa actttatttg cagagacagg caagccagat ctggccttac 40620tttactgacc tctgcttgga acgtcactct ccaagtgggc tggaaagggt tttcttttct 40680tctgggtctc acgcagtcct aaagcttcgt tctgttttag aaaactttgt tctcttttag 40740aaaactttat tgagcatttc tgcctgtgag aaatggcatg aaccacatgg ggttttcgct 40800tcaatttaat acctataagc tttactaagg acctgaccag caggctgctg gctgctgggg 40860acagggaggt gagaaggcag ggcctgggca tcagctggca aggaagacca accatggagc 40920acaccctcat cgactcacag gcttcactga atcttgtgac atgctagcat gctgtttaat 40980gtccttcgag gagagtttta taaagagcta gtggttcact gtggaagttg acactctggg 41040gccccaggtg acagttgcag gtgtctctgc tcctgccctg tcccacccat ctcattgtca 41100ccaaagggga gcagagagga aagtgttctg ggagaagttg aggaccctgt tcttccacag 41160actggcaggg aggcttcagc aagttgttcg tgcttcctgg tctgggtttt aactaaaaag 41220ggtctaacat ttcataattt aaaagaaagg gtccacccgc aattcttgga actttttgta 41280tctcaggtgt ttgtgcagaa gaatcatcga tactgtttct cctatggcat tggcggctgc 41340tgcaggggca gtgggcaatt cttgccatag acgaatagct cacttcatgc acatggcagg 41400gtttttaaca ataacactca gaaaagaacc gtgtacattc tgtgttacac aatctgctgt 41460agccgtgcac tgtaaaattt atacaggctc ctgtatagga aagttgaatg tgtagaggga 41520attggaagtg cagtaggtaa aagtttagga ggcctgattt tcctagtttt ggatgattaa 41580gaccaggtct tatgtgcagg attaaacagg agttaaaggg ggagatacct tttactaaat 41640ccagcctgtg agacaactag attgtctcat cctattttgt attgtgtcat taacatcaag 41700ttgcaacttg atattcggaa ttttttttac taacaagcat tcaaaatgaa atgattttaa 41760ttgtcagtgg aagtgatgag ctcatagaaa agaatgtttt cagtctttct caaggagggc 41820agcaggaaag caagttattg cccctgtttg tcatggggaa cttattcttc catattttcc 41880ttttaagtta gttttttttc caatttaaaa gaaaagttca agtaaccgtt tttcctagaa 41940tctctggctt ttgttatcat acccaacctt accttttttt ttttttcatg ttcttagagt 42000gtcttgcttt agtaaagtct ggagatacta aattatcggg tttatttttc tcagaattgc 42060tcctgcaact gaaaagtcaa ttttcccttg taattctgtg tttaacataa aaggctgaaa 42120ctgggcactg agatgtacct gtacgatatg tttgagctca tggaaggttt ccttgctttc 42180ggaatcacat ttgctactag aaatacaaat tttaatttta agaagtgtat cgtttcattt 42240tgtcaagtac atcagtattt gtaacactcc taattcagct atggctgaaa atgtgaaagc 42300atctttacct actccatgaa tttggcctct gggtggtcca gtgttgctca ccaaaggcct 42360gtgaggcccc atgtcccaca gccgtgccat ggggccctac gtggtggccg taagcccctc 42420tgcagagagg accggggcct ccctgggcag agctgccacg acccaggtgt atatcctgga 42480ttttgaacat cgaaatgtaa cattggaggc aaacatgtcc aaacccaaat tgtcaggaga 42540aattatgaag aaaaaggatt ggtgagtcag actgtgtgcc gaaaatgctg cctgatttta 42600ttggctggag caaattgacc ttatttccaa catgttctag gcttgatgcc cacttcagtt 42660ttctgtaatg tgattgcagt catggtgccc agctccgtgt gacatgtcat tgttgggaca 42720ttgttccata tattacaagg aagctttcct ccttgtctta atcacaatgt tttctagtga 42780tttgttttct ttcctccttt ctctctttcg ggggagtcaa gttgagcagt ttgaaggtgg 42840agcttttact gacagctctc tccttcattt gcattctgat tgctcttgta agtggaggag 42900aaaaggggag gaattattgc ccatctgcag ggcattatgg tgagtggcac aggggactgt 42960atcccacgta tgaatgtcat ctgtcacaag cgacagcaga aaggagatgc ggagtggata 43020cactgcacga catgtcacat ggaacaactc tcatctctgc taaaagtgtt tttgtttgtt 43080ggttttattt gctcaaataa ctctacgtgg atacgtctgt ggatggattt cctcacaaag 43140caacgtctaa gggacagagt agtacagtgt gtaatgagcg atgtgacaaa ttcaatgagt 43200atcagtaagt ttacattttt tatatagatt acctgtagca gcagaactgg tgtgtggtgt 43260tctgtcattg tgttcatgag caacacgtga gtcttattgt tttctttttg gttttgccat 43320tacagctgat gaattcagaa aatctcttcc ttcttagtga atattcaggg tagaacagcc 43380ataaaattaa taattctttg cttctactaa aatgaacaca gataatacaa caaataaatt 43440tttgctggaa tctcatcttc aggaagcctg aagtttgatc atatttaaag gttgaggatg 43500tcagatgatt agtgttagaa aattgttggt gtgttttttt cccctggtca ggatgaacca 43560ggctgatttt cagggtgagg gataacttca gttactttga aagtaaatga atataaaggc 43620aaaagtttac tctcattcct aggtttgaat ctctggagtg ttttccagct ttcttcttcc 43680tggggtaggg gagtgtcact gatgagtggg tggctgtcag gtgggtggta ggtatcgtgt 43740tgccgtggtg gtttcaacca ggggcaccag ctcttggtgt ttggtgtctg aaagctgtgt 43800gtgaactaca gagagccctc ctgagccctt gcacgtgtta atcatttagc cctatgcctg 43860gggcctttaa tagtatgtgt ggcaaagatt ctaccaccag ctcaattgga aaaaggtatt 43920tgagacatca gttcaggcag atggcttctg tcttagacct tctttctcta acaaatgaat 43980aaaaatgata cttagggttt caaaacagat cccttttttc caccataaat tcttagtact 44040gatgcttctt aggtctctgt tgtatcccaa tccctctgct gcggctggca ggtcctagtc 44100atctgggtcc aatctgaggt gtgctccagc cttttcctcg ctgccctttt gcacctccgc 44160aaaggattgt ttctgctggt taattctgtt taaatcaccg cgagcgcttc caagcatccc 44220aaagggtcac ctggaatcag cctcagcctc ctggggtggg gggatgtcta agcaagcagg 44280tctgtgagag gcagggcact ggggagcaaa accacaggcc tgtgcccgct gagcacaccc 44340agaccacagt tctcgcttta ccgtgaaagg aggcggccgt tgaaagcggt tgtattaacc 44400taacaggaga caggctaggt gagacacatg cacgttgtgc ttgctctggt gcacgtgtgt 44460gcatgtagat gtgtgtgaaa cgctgcacag ctgacacccc catgcctggc tctgagcggg 44520tggtcatcct gtttctggtc tccctcacct cagctctctt gtgtcctttg agtgtgccat 44580taacaggttc atcttcctgt aataaccctt ccttcctccc ttctccttcc ctttcccctt 44640cctccctcct tctttttttt tctttccttc cccttcctct tccccttcct cttcctcttc 44700cgcttgccct tccttttccc ctttccttct tttttttttt ttttttgtca gccatcttcc 44760cccaagttat cagtgaggcc ttgcaccaga gtagaattaa aaaaagaaaa ttgttgaaag 44820gtcattgcat gaataaatgc atggatgaat tacttccttg ccatttatca gctcttttct 44880tgcataatgc taatgcttag aaattaacgt tttgataact gtattctact tccaaaaaat 44940aaaattacat gttcaactta attggagctc gcaaagatgt aatgataaga gttgaatatt 45000acagcgatac agcatcctaa aaaaaacaat gaaaatgtca gtggcctcat gaaatcacaa 45060atgaaaatgg aaagtaattt ttttcagcaa taatttaccc gccatttata tgacaaagtg 45120cttaagtttg agaaactgaa gaacttacta gtttagctgt tttcaaaata acagacttag 45180agttaacatg agataattca gccacattta gctaattgtt agtgtcaaaa taaaataagc 45240aattgattag aaattcttct gtcaatggat ttgcagagtc tcagttacct gcttgtggtg 45300gccatgggat tcttcccaaa tcagggtctc agggacaaaa tgcaagctca ttttagggtg 45360aattacaagt ctcaaggtgt gttttagcaa atgcctgttt ttttttaggg gatacaaaca 45420attagattct cactgaagtc tcctgggatt gaaaatcaca acaataatga atcagataac 45480tcaaagacag atctttcctt aggaagaaat taattctgtt aaggttcatt ggcagaacat 45540tgtttactta ttaaatttat aatggacata aagcttttta aaaataacaa gataggccgg 45600ccgcagtggc ccacgcctgt aatcccagca ctttgggagg cctaagtggg tggatcacct 45660gaggtcagga gttcaagact agcctggcca gcatggtgaa accccgtctc tactaaaaat 45720acaaaaatta gccaggcatg gtggcacgta cctgtaatcc cagctacttg ggaggctgag 45780acacgagaat tgctcaaacc tgggaggtga aggttgcagt gaaccaagat catgccactg 45840cactccagcc tgggtgacag aataagactc catcttaaaa aagactaata ataataataa 45900ataaaataga taaaacagcc tcagaatgtc gcgttgtagg gaattttaaa atgtccactt 45960tgtatattga caagtatttt ttctgtaaag cttttggggt ttttgggggg ctatagcatg 46020tagtgcctcg agttcataag gagatgtggt tttgagggac tcactctcag cttcagggca 46080cactggaagt ttctgtcttg ttgagttcag tcctctaaac ttaagatgga gagaaaagaa 46140tttggttcac aaaaaagtaa gtcagggagt atgataagag gctaggatca gaattctaaa 46200ggattttaga agagtgtcca gaaatgcagt tggtataaat gcatctgcaa aggaaggaaa 46260tgtacctgtt tgagagcaaa gcggtgctca ccctcatgtt gctgagtgat gaaaatgaac 46320agtatgtcat tttggttaaa aagccaagaa gcttagaaag aagaaaacag cacgctgtga 46380aaggtcaaaa tcttccaatt tgttctgtcc cttgaagaag gaatatatca agtaaaaata 46440ggcctaaaac actggaaatt gagaaaggtt aaagaatttt gatccttcat cctggaaggg 46500aggaagcaat tagatctggc cacgtgtcct cagtccctgt cccctctgag cacagcgaaa 46560gggtaaatta cttaaactgg aacatatgaa agtttgagtg gataaaaata accctttcct 46620aatgttgagg gttatgcaac aacacatgag gccgtgcagg aaccttccat tgctgggcac 46680gttcaaaaag aggtagatga tccggttgga agttttctga gggcagaagt gtggagttat 46740tagttactcc actttcataa cataatgcac atttgtagaa taaacatagt ttacagagca 46800ttgtaatgtg tgtcatagtt tttcatctct gcagccctgg gaggaaggca agtggattct 46860gtgtatccca cacaacacag gaagcatcaa ggcctaagga gttacagggg tcattccatc 46920acacagacac gcagtgcaac ctaggaactg gcccttcttt ttctatcttg ttcgacagaa 46980tgattcacaa aaacacatgc gaatattttt cttaaattga aaatacgaac ctaactgtct 47040agacaactca ccatgaacct aacagctctg cttccaggaa aactcagagt tttcccactg 47100aactcacctc tggaaaacag aatgaataca tgtttctttc tcaaaggtca tcagtttatg 47160aaaatgaccc aggtcctagc tgtgggttag aggggccctt tctggaactc cagagattgc 47220tctgttctcc tgagggtctc tgctaacttc cctcctttct ttttcagagt gaagatctgt 47280ctggctttat caccaggatg tcacatgtca gagagtatca ttaaaagaag acgctcagca 47340ctgtttcagc ccgaagctgc ttgcagtttt cttttggatc tgagcaatga ctgtgtttgg 47400aaacatctgt ggactctgtt agatgaggca ccaacaaggc aaggtcacct gcctctttcc 47460cttgttcccg gatggggcat tcatcattgt gctgtttgcg ttttgttttg ttttgtttta 47520acaaaattag ctgaagaagt tattctcaag aaaattggat gttttcattg gccttcttaa 47580attgtggcca gtgtctttta atttcttctt cttttccttt tggcaaagca gatataaccc 47640tcagcatgct aggagagtgc acccgtacct atggaagtgg taaaatctgg tatttactgg 47700cttacactca aaacgaccac agtcctacct cagttcaagg taaagccgga tttccgtggc 47760gggggtccca caggacctcc tgtagtagcc cctgcgctgt gtgtctggag cgcggtcctc 47820ggccttattg aaatggtcca agtagacagc tgcttgttgg attccagtgc aggtacctgc 47880gatgtttacg tccacaccga gcccagtgtg ggactgacat ttctcaatgg aagtgaaatt 47940tgggattgga ctttgaagac ggattactaa ataataatta ttatatgtaa ctgaagcaac 48000ctacttttga aaatcaactg tattgggtag tgggaggtgg gagggaaggg ctttgggaag 48060gggatgaata tctcttttta cctttaacag acttgtttaa tcttctcgat gtagatgttt 48120atgtaggtac ttcacattgc aaacgccttt tattctattt acaagctcag atgtctctgc 48180tctcctgaat cttgggcatg cctttctgta accaaaaatc cctgtaggcg tgctagcaat 48240tccagggtgg tccgggtttg gcagatttga tttttaaaaa acgtattatc tttaataaaa 48300tgttattatg tcaaccagtg aggctgccct gaacaaaaaa aacaaaaaga aaaaaaaaaa 48360aggaaagaaa gaaactgata aaaagaggca ttccagcccc tatgttattg atggaaaaag 48420aaaaagaaga aaagcaatct cgcagtacat gttacttgtc gaaaaaattc cggacaagac 48480tacccttgtt ttatgttttc agtattctga aaataccagt gtgtggcagt tctcgcagat 48540gttacctaaa actgctgaac ttgaccggca gaatgttctg ccgttttctg ctccctcgac 48600acttgattgg agggctgtcg acctctcctc ccgtgggggc ttccccagtg cctatcttct 48660ctgatagtca tggagaggtt acactaattc attggagatg taagttgttg gttttgtttt 48720gttttgtttt tagaaaaata tatataaata tataatagat atctatcgct atagaataat 48780gcattaataa aatgaggctt ttttagagga agaccaaaaa attcaatgtc ttaaaaatat 48840atttaatggc aatgcaaaag tcttcctgct tccgtgctga actttagaac agaggattgt 48900attgcaagac aaagttgaat gtaaagtgat ctccctgaac atttttaagg ttttactttt 48960ctgaaattat acatcacagc agtgcatagg ccatataatg ttagctggaa ggtcaatttc 49020agtgtatgat atactttatt aagatgtata aaaatcctga agtttttatt tagttttggg 49080aataggcatc aatgggtggt atttgctttg taactccccc caggtacgat agggactgaa 49140tatggaccct gctgaaagca gtgtattgac gcatatttaa ctcgccctct atccgtagag 49200tagtcatgac actatacaga tggttcgtgt tcatactgca gcttaaaaca agcaaaatac 49260acagatgata atatgctaaa ttttcctcta tcctgtacat ttcacaaaaa ggcatatgca 49320atatttacat ttttaattta gtttacagaa tggaaccaaa atgtataaat gttatgtttg 49380ctaaaacttc acaatgtata ttgggtcttt gtacattttg cctgacttac cttaaattta 49440aaatattttt tgctatataa actttaacag ttattaaaca gtgttttctt tttgggtacg 49500tattgtttct ggatatcaag atgttaaata tatttcttgc tattgtgata tgacaagaga 49560cttaacttat cttgctctgt cttccactgt acacgctgta tataggggtc aatgtgatgc 49620tgctggagac gagaataaac tggactagaa tagtgcattg tatttagtct gtattgatca 49680tggatgccct ccttaatagc catatgcaat aaaataaagt acattattta tgaaatgaat 49740acagtcctga agattttttc tgtacgaatt ctctgtttaa cataaagcca atctactttt 49800agagtttggg agtaagtgag gaaatactag gctcctaaaa atacttggat acccctttta 49860attttaaaac ttttattctg gaagccaaaa aatacctgcc agataacaac atttatgaaa 49920agtaaatgtg ttatataaca aaacagaaca ttcgatgtac tctacaaaac agagtcctta 49980tgacgtgctg gatgccattc taaatacata acaaatatta acttcttgat agctcatgac 50040aatcttagga ggtaagaatt gtcatcctca ttctacagag gaggagcccg aggtacaaaa 50100atgctaagag acttgtgtga gagcacacag tccatgagtg gtaaaaccag gaccgctccc 50160cagctctgca gtccagaatc tgcttatgca cctctgctta gtgctccctt cctgatgtgc 50220acacagaaga tacaccaacg tgtacatcaa gaatgctccc tccatgacat gcacacagaa 50280gatgtaccaa tgcatacatt aagaatgctt cctccggccg ggcgtggtgg ctcacacctg 50340taatcccagc actttgggag gctgaggcag gcagatcacc tgaggtcagg agttcgagac 50400aagcctgacc aacatggaga aaccccgtct ctactaaaaa tacaaaatta gccaggcgtg 50460gtggcgcatg cctgtaatcc cagctactcg ggaggctgag

gcaggagaat ggcttgaacc 50520cgggaggcag aggttgccgt gagccaagat aatgccattg cactccagcc tgggcaacaa 50580gagcgaaact ccgtctcaaa aaaaaaaaaa aaaaagaaga agaatgctgc ctccatgaca 50640caaacacaga agaagacata ccgatgcata catcaagaat acaaagaaga aaatcatcag 50700atccaggaaa atgcaattca ggaagcagaa aatagaaaat tgatgctgtg aatttttatc 50760caggagagtt ttacctcctt gcttgaaaca tttgtccgtg catccacttt gccctaaaat 50820gatagtcatg taataatgtg tgtgttatct tttgaacaaa taaaatcagt gcaatttgga 50880aggtgatttt taaattacgg ttgttaagtc agcaagatgg actcacactg tggtgtggaa 50940acctgtgatg ggatagccac aggctgcatc ccctgtttgt gcctggatgg tttgttctgg 51000gggagcctgt tagtcacaca gagtaagagg cctgatctgc aagtcttgat atacctgaaa 51060tctgataacc atttcaacaa tgaaagggca aatgatgcag tcattccaca ggcctcatct 51120aaggcaggaa cggacaagtg atttatctga aagagccatt gtggagaaag tacagcaaaa 51180tggagttgtt tcaaaggtcc acagattctg gaaataccac tcaaaaccaa tgcagggcct 51240tttccagaat gttaagtgtt atatgacaag atgagaagac tgcaggctgc aataattttg 51300gaagaatttg gttctaaccc actgatggcc tcgacaggca gcttgcaaga ggcaccttag 51360ctcatggtac tgtcatgata tttgagtccc atccttgagc tgatctgcag ctcgtccttc 51420ctcaaacctt ccttaagcat tgcttcacag attagatggg ttgctcatta gtgcatatca 51480ctgtgagttg accaggggta atagcatttg agtgaagcta gcattacttg acatagcaac 51540ttttggatgg caccagttga aggacagagg ggacgattcc tccactgaga atgtgcagtg 51600tctcttccct gtcattgccc cagtagtatt tctctgaatt ctataaccaa gtgaaatctg 51660atgtttatgg gtcttgcttt ggcaatgata cacagatgat agacctagca tgctgcagtt 51720gatagcttga aaacattaag catcccttca ggagctcctt ttagattttg accctcacag 51780ctgtgtcttt cctcttgtct cttcagcctt gtttccctct gcagatccca atgaccctaa 51840atagcaattt ggtggtttct tgtcctctta tcattagtgc ctccttcatt tcacactggt 51900cccgctttcc tacctgagcg gtcagatgac tcacagcctt tccgctgcat ctggagactc 51960tgtcctattt taggcacttg gttcctctga caggagctct gtctgagttt gtgcctctga 52020acttttcttt ttctgcattt caaaatcctc tcctttcacc ttggaactca aaaagttcta 52080aatttttacg aaaattactt ataccccagg aaacctaccc cagctctttt ccagcctgtc 52140tgggtgtgtc aaatacatat caggaactgt acaacgtgct cctgtctctc cagatctttc 52200tggttatgac acttaattct cagatgacat tgacagaaaa catactgatt gatagatttt 52260tctagaaaag atgcataaaa caataaagga gctgtattaa ttagcatgca tttagctgca 52320agtaattgaa acctcaattc aatggctctt agctgatctg agctgctata acaaaatgcc 52380atagactggg tagcttatag gcaatagtat tttttttccc tcacaattct ggaggctgag 52440aagtctaaga acaagctgct ataatgtggt gtctggtgaa ggcctgctgc ctgcttcata 52500gatggtactg tctcagtgcc ctcccgtgac agaagggttg acctagctct ctggggtccc 52560tttcataagg gcactaatcc tattcatgag agctctgccc tcatgactga atcacttcct 52620aaagaccccc acctcctaat accagcactt tggggattca aattttaata taggagtggt 52680gggaggacac agacattcag actgtagcaa gctcagagca gtagttctca aacttcagga 52740cttcttagaa ttatctggag gggcttgtta aaaacagatt gctggactcc actcctagac 52800tcttctcagc aagtctgggg tagggcccca aaatctgcat ttctaaaaat ttccagatga 52860tgctgatact ggtctgggac cacacagtga aaatcactaa attgcaaagg gatgtgttaa 52920ctcacacaac aggaagccca gggctggtta attaggcagc taagtggcgt gcacagaagc 52980cctggatctc ttcatctttc tactcagcca tcctcccgat ctttgctttc atttcagacg 53040cttggccccc tgtgtttcta agatggttgc ggcagctcca ggcagcatgt catctcataa 53100caatgtccag caaagcagtg tctcttcctg gggtgtcttt ttggaatgat gcaaatgacc 53160ccagagccac cccaccacca gctgcctctg cctcacttcc attgtctggg attgggtccc 53220aagctcctgg ttccattgat tatgaggaag gagatggctg atttacacta aaagagatgc 53280accctccagg gctgggaggt gtccacatcc catgaagaga cagttgaaca aaagctgggc 53340attggaaacc aggaaaaagg agtactgtca cttcagtagc aactaacagt gtctgctata 53400acagcagaaa atgaaagggc catccttttc aaatgcaatt atatctctaa tgtatgatct 53460ccatctacag cgattttgaa aggggggatt taaaataggg taaaagtaga acaaaattat 53520gaatctagca tggtcaaaaa gaggatggcg tcattgcttc actataggct tcacgtatct 53580ttgcttttgt tattaaattt tgtgcaacat gggaagctgt tttataaaag atcaagatat 53640aaaggattgg aaaattggac atttgaaggt acatcaaaga gctaggacta tttagactgg 53700aaaagaggaa actacgtggt gattgattag cattgataac attaggggct atagataaaa 53760taaagattag tcagctgacc tcctcaaaag atgataaaac cagagaaagg ggtagaatac 53820aattagaaaa atgtgtccga tttccataaa aaataatttg ataataacga gggttattaa 53880atatcaactt tgaaataatt gttgatttca ttgcctggag gccttaaaaa ataggacttt 53940gcagctgtct ttcttcgtag tgatgggaga ggggacatag accacataat ctcgaccagc 54000cccttccccc aggggctcag catcgcacag ctgaggaggc agccaccccc tttgttgctc 54060atgtcaacag ctcccctgga cttgcacagg gcatggcctg aagcctgaga tcctggcttc 54120tctgaggata agagaactac tgagcatgga tttaatcagc aaaaagaatc accatagttt 54180tttctgccta gtttagtctg taaagtgttt accaaagtag tatttaggaa tctgaaggaa 54240agatctgaaa tttgaaggaa ggatcagagt atgaggtcca tcctgaatag tccagattca 54300taagattata agatcataag atcatgctga tagagcagct ctaaatcatg ttgcttaaag 54360aggtttttaa atacaggaca gccaaagtga caaagtgatc tttatcaaat agccgggccc 54420tcttgctggc acctgtagtc ccagctactt aggaggctaa gttgggaggg tcacttgagc 54480ccaagagttg ggggccaaac tgcacaatat agctagatcc tgtctcaaaa aagaaaaaaa 54540aaataaatgc atgtataatt caaattctcc ttcctcccca ctcacccatt atcttttagg 54600aaaagtcaaa gttcctgaac gtggtaggcc tgagacataa ggcactatat gaactggctt 54660ctgcctaatt ccccagacac atcttcaagg ccctgtccct cccgctccac ccctccctgt 54720gtctgcacct aagccttcct agagcacata aagtgcacct agctcaagta aggaggagaa 54780cataaaatga aaagacaaag aattgctgaa cctaaaaaca aatgtttatc taccaagagt 54840tactatttcc taaaagatcc cttgaggaaa ggtatgcaac aagttagaag catttttaaa 54900aataccattt aaatgctata cagcattgct tcacttcttc ctttgaaatc tgaggacatt 54960catcatctca tttccattca cctctccttt ctcctttttc cccaccttaa catttgtcag 55020ttacattatt ttctgcattt tcaaggtaaa aaaatacatt ttttctgtaa tgtaattcct 55080atgagtttaa aatacttatc cttcatttac attgatccat ttcatgccac ccgttctttg 55140aacatgctta ttttttaacc atctattaat tgcttggatt ttgttactga aaacaaacaa 55200ctcaaaactt ctttccagac actttttaat atgctctgtt ccctgagctc tctcatattt 55260gagaggtaat ttgcctgttg tctttataga tgagcaacaa attggctatg tagatcactc 55320ttaggtccca tacgcctttc caaagaagtt tgtgacattt ctccagcctt cttatttatt 55380gaatcaggag attttgatga gtggttttca agttcaaatt actctgggga aattcacctt 55440gcacaaaggt gccctaaata tacaacccta tctacctaac cagactcacc ttctgccttc 55500taccacccca tgaacccagc gttggtcaca gttgcactga tcctatcacc aaattttaat 55560ccttttatga ctcggctttg cataaaaatt tcatttgccc tagagtgttg aaacctcttt 55620cttcatctag agacttgtac tgactcttca agacaactct accatgtgtc aggagaagga 55680aaactggaaa tatccagtga atgcttccaa tgactataat gcaacctgat ttcaactcac 55740ctaaacagag ctagtgaccc acttctccag attctcaaac cactctgctt acccttctgt 55800tacggcacct tccaagtttc actgtattat ctgtttatct gtgtttctcc cacgaggggg 55860ctccttgatg gaaaggatca cattgcagac atggtagcta gcaaaactgt gttactgtaa 55920ccgctgagca actctgttca gacatttatc tacctctcat tccatattca cacacctctg 55980agaactaagt gctattaaga aaactgaagc tcagaaaggt taaacacctt gctcagggtc 56040acaactaata agcagtgagt cagaattcaa agcatttatt ccaattccag ctctttccta 56100ctgtgtttta gtgaacctaa cacaatacac gacacatagt agtaggtact caacaaatat 56160ttgttgaata tttgaatgaa tgcatttgtc ttgtatacat ctagaacact cgcaggctaa 56220gagactaggt tgccttgaat gattgtattc tatatttgca caatttcttc aacaattacg 56280ctgttttatt ggctttatga aggcataaca ttgctcagag aagtaaagtg cattcgttga 56340attataataa gtgactaaaa ttgaatccca atggttctct gatatatgta taggaaacct 56400ttaactatat atagcagaaa agccaaaaca acaatggctg gaacatatat aatgttttat 56460tctctcagat gaaactagac agatgtgggc attccaaggc tggcacgggg tttccatcac 56520ttcccaggac ccaccttccc accgtcattc agctttagca ttttcagtgc acacctttct 56580gtcttcaagg tgcctcatag tccaacgtgg ctcctgaagc tccagccatc acactggctt 56640tatccacaag aaaggtgaaa ggggaaagta taaaaatggg tgcctctgct gggcgagtca 56700gctactttat aagtgagtct tccacttaag tcttgtacgc tgcatatttg aaacacctca 56760ctgagaacat ttcctttctc catgattgat ttctgcgact aatttctatt gcattctcct 56820cctcatccga tatgcttctg gatactggag atcgagtgga gaggaagcct gagtgcctgg 56880acttataagg ccttcttctg gtgatcagca agtaaaacaa atatgaaaca caagatgaag 56940ataagaaccg ggaggaatag cccaggcgtg ggggagagaa ggctggtttc caggggatgg 57000tcagaggcgg cctctcggag aaggcaacac ttgatcagag ttcccaaagg gcctactgtg 57060gggacctgaa ggaagagcag cgcagcaggt gcaaaggccc cggggtggag gcatacttga 57120catggtggag accaggaagg agggccacga ctcggtccct catctctcat tccacttttt 57180aacagttctc tatttagaac tcccatgttt caatgagaac ctattataga aacagtctat 57240caaagtcttg ccatttaagg gtgatcatta agagctttgc tttacttctt cacacagaga 57300aggggtggga gaggaggaag gacagtgtga agcagacaga cagaaactcc cctttggctt 57360tgaaggtgta ttctttgggg gtgccgacat attccacaag acaaggcagg gcacagggag 57420gctgggcgtt cacgtagaca gtgtgtcttc cagcagaagg tgtgcgtgac gcccgcctgc 57480acaggaacgg gtgcaagcac tcaatacctg gtttctatcg gggcactgcc tgggctctgc 57540tgtttcaaca atgcacttgg cttcttccat gacccagagt tgctgcagaa accactgctg 57600agagtacgat tgattctctg tatgccgacg tgtccaagga cagttagtag gagcggaggt 57660ttcagggcat caaggagtac tgtccttgca cacgggcaag gtactgataa gctgttgtct 57720gaagcccgag agccggtgca ccctgccgtg accaggcgca gctctgtgct gcaggataac 57780gcgagctatc tcatcactgt ctcatcactc aaaaggcttc tgatgaaggc cgtggctgaa 57840tgggttcggt ctcatgctaa caaaatcttg atgcggatgc accctccatc ccatgtttaa 57900gatctttaat tttatgggta cgagtaataa aaaataatca ggctgtgtat tttctgtatc 57960cactgatata aatgttggca tcagcattat tataatctta attaccatca ttggttacac 58020gtgctaaaaa tgttcacgcc gtctaaaaga aaataaaaac aagcggcggc aggacccctg 58080ctctcacaca gtaaagggca ataaacattt atcgacatgc tgaggagagg agattgtcat 58140atcctattaa aataaccaaa gataaggttt taaagaattc aacctgtcgg gctgtctttt 58200catacgaagg ccagagactt cccggaaacc gcgatgtccg cagtggcgtg gtaggatctg 58260gttggtaact gtgcaccgcg gggtatgtga gcgcaggcgc tcccggagca gcgacacaga 58320cctgttcatt tgaaaggcat tagaggagaa actcctgcgg tcagccttgc caacctcctt 58380tgtccccgtg gatgtgtctg gacacccttc atcaccctcc ctcgggggac gggaagcctc 58440agttaagagc gaggcccagt gccctccctc caggaaaccc cataaccttc acttccaggg 58500taaggggctt cgtctacaca agctccaccc gtcagcccca gcagcctttg agctagagct 58560ggcggagggc accgcctggc tctgcttctc ctccaccgcc ctgcccttca gagagccagg 58620ccagggagtg gaggcatgag gggcgaaccc taggggcgtt tgcctgggat tctgctgttg 58680gcctccctgc tgggtgtggc tgaggcccga tgcccactgc tgcatggcgc cacggcagcc 58740cttgccccgc caccccatcc acagccctaa ggaggcttcc tcagccgctc tgtggagctt 58800tcgaggatcc gcttgaagat gtcagcacac tcctccctgg ccggcagcca atagtttgtt 58860tattgctctc aaagcacact cacactcttt cctcccgtcc agtccatttt ctgaaaacac 58920tgagctcttg gctcacggtc aatgccttct gcttttatct gctcggcctg aaacagtgac 58980gtccagccaa gaggccagag ctagggctcc tccgatgctc ctccgatgct ccaacggtgg 59040tggccctgct cctcgatgag gccggttccc gcaaggccga tgcttaggca tttcagagag 59100atgcactctc cctcttctta tcgctttccc cttctgcttt attaaaatta ggtgactttt 59160caagactcca tgcaaaaggt ggcatgcata gctctggcca tgcaatagaa actaaagtaa 59220ggttcccgtg tataatccaa tcacacagct gccccgcctt ggtctcacac caggtctgca 59280agatggcagc ccctttggtt tgccctccag ccttctctta agtcctggag ccgctctggt 59340aattgagcct tccttctggc atcctctgga aggctaattg aatacagcag gaggcagtca 59400cagagctttt tagcatttct acttcctttc atttgcacac ttttccaata ggaagcaaag 59460ctactcaatt caggagagaa ctcccctctc ttcctactta acctttctcc tgcatacaca 59520atcgggctac tcaaaggtat gctgtttcct ttccgctaaa agtttcctcc taattacctc 59580gaggcatcca ggtgtggctg aaaatatgct caaccccggg tgtaaatatc tgcacctaag 59640ggcagtgagt agcagagcaa aacagcttgt gcagggcgca gtgtgcttaa aacaacctgc 59700agctatttat cgggtgactc agacaggatg caggggccag atggttagca tcttgcaaag 59760gctgacgggc actttcattt gattgtttaa gaataagttc acaccggaaa ggggatttca 59820cacgtcctct tccattctgg attttcagtg tttcattaag ctactttata aactattatc 59880ttggagaaga aacaaaaaaa cttttaatta tgtttccttt gcattggcgg tcaggcagac 59940agatgaaatt tttaattatt gaactgctcc aaggtgtgcc tgtaagtata tctaaaatat 60000gtcttgaaat agttattgta cctttttcta gaaaatgata acttctatgt tttctttgta 60060aaataaaaac ccacttgtga ctggtataca aggaagaagc tgacctgaag ctgtctaaat 60120aataaaggca aaactagtag acccccaaaa acgatagagc tcactcttct ctgtctctgg 60180cacgtggaga aggcatgaaa ctatcaaagg ccccaggaat tgaacttggg aaaacttggt 60240tcaagtcggg tggggcagtg ggcaaagggt tgatgttgtt gaatgtcatg gacttcataa 60300tcagtaggca taaggatatg atcgcttaga tgtttagcgt ggcagtgaaa tagtaaaagt 60360gcataaaggt agtctttaaa gagtgagcga agcaccatgc cgggtaggta ttgaagccat 60420gtcagttact aagctgaaca tcaacaattt gctttggtgc tttggcacat acctaaaatt 60480gtcaagtgag tcctttattg aaaggtaagg atgcttgttg tctagtttct ttggatgttt 60540ttatttggaa aaccttgggt gaagtgtcat taaataatat atgatactgc ttttccttct 60600ttccttcctc ttccccttct ccttcctctc tctcttcctt tcctctttct ttcttgacag 60660ggtctcactc tttcactcag gctggcatgc attaggtgct atcagagctc accacagttt 60720cgaaatgcca gactcaaggg attctctcac ctcagcctcc tgagttgctg ggactacagg 60780catgcaccgc acctggctaa tgtttaaaaa tgttttggcc gggcgtggtg gctcatgcct 60840gtaatcccag cactttggga ggccgaggcg ggtggatcat gaagtcagga gtttgagacc 60900agactggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta gctgggcgtg 60960gtgtcacacg cttataatcc cagctacttg ggaagctgag gcagaagaat cgcttgaacc 61020tgagagatgg aggttgcagt gagctgagat catgccactg cattccagcc tgggcaacag 61080agtgagactc catctcaaaa aaaaaaatat tttgtagaga tggggtttct tttgttgccc 61140aggctggtct tgaactcctg gcctcaagcg atcctgccca ccatggcctc ttaaagtgct 61200cggattacag acgtgagcca ctgtgcctaa taatgctttt caaatgtcaa catgcacaca 61260aatctctctg gcgatctcgt taaaatgcag agtctgattc aggaggttgg gtggagattg 61320agagcctcat ttctaaccag ctcctgggtg atgctgatgt tgggctgggg cacgcatttc 61380ggacagtgag gggtgggtga tgtgaagcag acagtagaca ggaaatgcat gttgagaaga 61440ggagctaaat cctgaaagtc agtggccctc accttattcg ttcttcctca aactctgcct 61500tacccagggg gcacagtaat acgccttaca agtcctgagg tggaacagga ggatggactc 61560acagacatgg caggaaggga gctgggaacc agaactgtct gggctctgag gctggagtgc 61620tgagggcctc cgccctgact aggggtgtct ggtggaggat ccagcacaga cccactggct 61680ggaaggatcc ctgtaaaatc cctgaaagag aggaggagcc tcaccccaaa tgaatgcctc 61740ttctctaggc ctctctgcag ccacccatgc atgccagagg tccatgcaag atttgccttc 61800tggagcttgg ggagaagtaa ccagaagtca tgtaaacatc atggtcttga ttctttccct 61860tcctgctgat cctgtctcac tccagtgtgg ccctcaatga ctttccttct ccttttctgc 61920aaatgtacct gacggcttgc cagacagaat ttccatgctt ggttagaaag gacgatgcag 61980ctgagatgtg agatatttat tgcctctcga ctggagtttg tgtgacaccg cacctttcat 62040ccgcacgttt gtctcccatc tcataaaggt cagagttctc atctgtgcac cgctctcttg 62100cttgacaccc cttccccagg tgccctcatc cccccatgac ttcagctccc tcatctacat 62160cctcaacttt gacttccacc ctcacatcca ctgctgcctg cgcggcaact cccagggctg 62220tgccatggat gccccatgcc tagcttctca aacagaaggt ctcaccctgc catggcctgc 62280tcctcctgct gaatctaagc cccactcagc cattgcagcc aaacatactc tgcctcttcc 62340gaacaagacc tgggctggca tctcacaaga tcgcatggcc tgagtccatc tgcatgccga 62400tggcactcaa atccactctg catctccaca tgcctagcct gcacatgcct caaaaccaac 62460atgatcaaag cgtggtcttt cctgaacaga cccacccagc ccacccctaa ggtgccctcc 62520caccagcctt ctctgcaccg ataaacggca ccaccagccg tccacacact caggccaacc 62580agccgagcac tcgccaggac tcctccatct cacagcccac attccatcct tcagcaactc 62640tgtcgccttg acctcagagc atatcccggt ctcagtccaa cctcctctca tcccttcccc 62700tgatagaaaa gtcgccatcc tttcttgctt gggctacaca gcagcctcct aagtggcctc 62760cccctggcat ccttcccctc attccactcc attctcccta ctacagtgca gcgtcagcca 62820gttcagatcc ctcccatgtc ttccagcaca cttgaagcag aatctgccct cccttccagg 62880gtgcacaaag gcctactgtg tgtcacgtcc attcgtgcca atattgcaca tccattcacc 62940tttaaatgtt gttgggctga gggtacgact gggaaaggag aaaataaaga tctaattttg 63000attaggcgat tcatgttcac acaatcattt gaactgaaaa tgcccatctg aatgcccaca 63060cagacgtcat ctatatgaat tggtataatc agcacatgag aataaaagtc cttgcctgca 63120ctttcctctt ttcctttata acagcagtgc tcgcacattc aattccggca cggtcacctc 63180tgactcgctc gtcactgccg cttgccatca caggtgtttc ctggtcagtc actgtccact 63240ggctgcatcc catggtgcaa gctcattctg gaaccttgtc tttgagctgc ttcctctcgt 63300tctatcttct gcagatacca ctcctctgtg gtctggggat tttctctgcc aagaacatca 63360tgcagtttgg gggtgcagtt cccatttgtc tcttgacaaa gggaaacaca agtggattga 63420aagcaaaaac ataagggctc tttccccgaa gccattcctg aatcctgaaa ctgaaagagg 63480ggatccagag gaagtgtgga attagttatc atggaaaaat ccagggtgga aataaattag 63540gctaatgata aaataattga acaacattct tgggtctgac ttcttaagcc acagtgttag 63600aagttggcat agaatctgat cccttatgtt acaggatcat ctatttcatg ccgtataata 63660tagtacagta ggcataatcc ttttggggat agacttggat taaataaaaa ttatgaaact 63720taatgtcact gtgtcttcaa tcattttctt ttcctttctt tattattatt ttgagacaga 63780gtctcactct gtggcccagg ctggagtgca gtggcacaat ctcggctcac tgcaacctct 63840gcctcctggg ttcaagcgat tctcctgcct cagcctcccc agtagctggg attacaggcg 63900tgtgccacca cacgctacta attttcgtat ttttagtaga gacgggggtt tcactatgtt 63960ggccaggctg atctcaaact cctgaccttt tgatctgccc gcctcagcct cccaaagtgc 64020tgggattgca ggcatgaacc accatgccca gcccgatcat ttttcttttt aatcacttac 64080aaaacattaa ttttcaaaag gagaaaagaa ggtggggtag actaggatcc aggagaaaag 64140tgtgttcacc tgtgtgggac tcagcaaaca tttgacctct cggggcctca ctttccttct 64200acctgaatca tctcacaggt gactgaaata gattaatgca gcaaatatct atactgatca 64260cctaccttct atcagtgccc ctatgcccca aggcatgggt ccttcataca attcttttaa 64320aataaattat tacaaattga tatcaaatta ttatttggag acagggtctt gctctgttgc 64380ccatgctgga gtgcagtggc atgatcatac cttattgcag ccttgacctc ctgggctcaa 64440gcgatccttc cacctcagcc tcccaggtag ctgggactac aggcacatgg caccacgcct 64500ggctaatttt ttggattttt tttttagtag agatgaggtc ttgctatgtt gctcatgctg 64560gtctcaagat cctgggttca agcaatctgc tctcacaaag tgctgagatt acaggtttga 64620gccaccatgc ccagccaatt agataaaatt attataaaat aaattaattt tataataaat 64680gacaaccatt caaaataaac cctgaagatc ctttacccaa ttcactaagt tacattgtat 64740atgacagatt atagtatcaa acggcaagtc tcagggccat acactaagcc ttatcgggaa 64800ctgaaagtga tccatctcca agattttgaa cacagaagtt cccctgcttg gccacagcgc 64860ccctcttccc ttgtcctttt ccccttcctg gagcatcctg gggtagactg actgtcaaaa 64920cagcccacgc gttccgctgt cttgccctgc cctgcatcca gcctgcggtg atgtcacttt 64980gtggctcttc tcatctggaa gtagagggta tttctctgca ctcctgagtc tggccagcct 65040tgcaactcac tgtggccaat ggaatgtgga ggaagtggca ggtgcccgtc ccaaacctat 65100cctcagaagc tgtctgctgg gaaacaagcc caggcaaatc tgcgagatga agagagacca 65160cacggagccg gcaccagtcc atccggttgt ctcagacacg taggaagccc agcaggatga 65220gccgtcgcca gccccccatc ccgactcaca gacttatgag caaaggtcaa ggtgtgctgg 65280tgtccgccat gaggttgtgt ggttgttcag tcccgtgtcc aggtgatgga cacctcctgt 65340ccctcccctc ttcctcattc tcccagccca tctccgttgc acagtctcac gtacctttct 65400gtccacactg atcctgaggc agctgtgtga gcataaactg aggcaagaga ccagcccaga 65460aaggctgaca gatttcaaat ctcagacccc aggtgacctt gtggtaaggg acattcctca 65520ccctgggtgg caggtgacac tacaagtcaa gtcggtaatt

ctaatctcaa cttaggtccc 65580attgatgttt tgttattcct gtctctttaa atgacacctc aggtgactca atacatggac 65640tttttcactc cctccccttc ggcccactta cctgctacta ggcctgctcc acacaagtga 65700tctcatatcc aggaggtggg gtgccccaag caggagtccc cctcctctcc ctcctctctt 65760ctttaagctg tccctgctcc tcctcacaca ccccagcttc ctgcattttg cttcatgctc 65820agagctagcc agctgttcag caagcactcg atcagaggct gttctacgac aagggcatcg 65880ttcctgcctt gagtcactct caagctaatc agcgtgggtg gctggtggaa aacatgcctg 65940tgagaaagca aatgagtgga tggcatcatt gggacctcat ataaagaaca aagactcatg 66000gagacactag aaaatggaac cgccccaggg aagctctata gagagaaaat ccagctacac 66060cttggaagga aaaagacctt tgtccagata gagaaaggaa aaaatagaac atccatctac 66120ttcttgcctc gccacttatg ccgtgctcct ttgcaatatg gactctgcca ccctcagccg 66180ttgacagggc tgtgttgaca accttctcga tgccaccgtt gcaagagctc ccaaccccct 66240gcagcagcag ctcactctgt tgactccttc ctgcctaata aaggtcatag gcaccattcc 66300ttagtgctag ttgtcacaag accttgcacc aaacacctta cgtcttattt cacccttgca 66360acaactccca tttacaatgc agagaagcgc tgacagggcg ctcagataga tgtcccaggt 66420tacaagacca cactagcaga atcatggctt caccctgagt ccggctaatt ccacatctat 66480gcgcagccac cctgcccctc gccttccctg cagggcgagt ggctgaacat tttctttggc 66540tagtgcaatg gccacccctt ctttctccct ctgctctcta aatgtccttg accctcaact 66600tcccaacaat gacttcccat ccctcacttc cttcctgtgt gatctccttc tctggagatc 66660ccttactgcc tttctctctt tgcagccacc tctcaaatcc cagaagccag gatgttacat 66720gtgcaatttc cctgcaaggt gccttaattt ggttttccta atggcatctt aaattcaaca 66780tgtccagaat ggatcagtgt cttccctgaa aaccaattcc atctcttgac cattttctct 66840aagtcactgg ggctaaaatt tagagggcca cttatttctg acagctccct ccccacatcc 66900ttgggccctc cccacatcca atcaactcct gtctgaaatg tgacttgtaa ccgcccctcc 66960cttgccattc ccactgatag cactttactt attacttgtt acttcttgct gggccacaga 67020aacggctgga ctcaccttcc tgtctctggt ttatgtgcca ttcagagaaa ctctgagaca 67080tcacctgacg aatcattgtg atgctcagct tgcaggatcc cacttctcta ctcagggacc 67140cccagtactt ccccgttctt actgaataaa gtccaaattc tacacttcag tgttctagcc 67200ccttatcacg tgggcggtga aacctttggc tgcatctcgg acagctcatg ggcaggtccc 67260ctctgctgtc acacccagag ttaggaaggc ctcaaattca ctccctgcac acttgcttcc 67320ctgtctcctg gcaaactgct ttctctttgt tcttaactct gcctgggaaa atcttcccca 67380tccttgaagg cctttctcca ctgttacccc tgcatgaaga cctcactgac cccccaaaaa 67440gtgtttgacc cagaacactt tggcttttgc ttataatatt tacctctgac ttggggcacg 67500tgtttcattc tctatttgag tgtatgctct ttgagggtag gaatgagtga ctgtctggcc 67560taccctgaat cttgactctc atgaatcaag ttttataaat tgactcaaaa taataagtta 67620gagttacaag aataaggtgg taacggtggt tttataattc agaaataatc cttttaaaaa 67680tgtaaaaaat actctaaaaa agtcagctgt agaggtttgc tcgtggttgc caaggagcaa 67740agactttcag agagcttaac tccagtgggt ttgagcctct ttctgattaa agcatcagtg 67800ccaatagcat tggatccctc caagaatgtg gtgtttggga ctttaccatc atttgtttgt 67860ggaattgtgt gtaggtctga aaattcaggc ctgtggggaa ctaactttga attttgataa 67920atgactttcg tggtcagttc gggtcaccca gctacactct gttgtgtata ttttggcaca 67980tctgctcttg aaagatatga ttatatgtaa ctccaacaaa tatatcaaaa gtgtgtttta 68040atttttttgc cttttagatt taatgaacca gttcctaaga gaaccctaca tgtttcttta 68100gaagacctaa ccaattgata ctgcattatg acaaaccctc taccagaatt tcctcattca 68160ttcaaaatta tgtttaaacc cataatgtcc acattctttt tttttttaac atgaggagac 68220atcataagaa atgaaacaac agtttgagtc agggcaacag agtccaagtt tccttccaag 68280aggccaagtt gttttagcag aaaaggacat tggcgccaaa acccacacta ggtccaccgg 68340cagcaaacac agaatggtgc cctcactcta ggaagctggc tgttccatat ttttatacta 68400gatttaaggt tcaaaatttc atgttggtgt tcataaatgc aaacacacaa gccagcaaag 68460aaaaaggaga gttatttagt ttatattttc ttctcccatc ctttctctct ctctttctat 68520gcaaatgttt caatcacata ggtttgacca aatagctgcg tcttacacca ttctcctcta 68580tgtaaagatg taaagcaact ctgcactttt tttttttttt tttttaagac aaagtctcac 68640tctgtggctc aggttggagt gcagtggcac aatttcggct cactgaaacc tctgcgtctt 68700gggttcaagc gattctcctg cctcagcctc ccgagtagct gggattacag gtgtgtgcca 68760ccacacctaa tttttgtatt tttattagtc agggggttca ccatgttggc caggctggtc 68820ttgaactcct gacctcaggt gacctgcctg cctcagcctc ccaaagtgct gggattacag 68880gcctgagcca ccccgaccgg ccatgcactt ggttttgaga gcagcacagt ggcggtctgt 68940tctccctgcc cgcctgctcc agggagagga gttgcttgct cccttacagc cctcacctcc 69000catgggaccc tgcaggtgct gagggctcag gcgcagctgc tgccagtcgt cacagccatc 69060tcatccattc cagagttgta aataggctga tgattccgtt ttttgttccc agagctgtat 69120atccagtggc ctcctggagt cacctactgg gatggctgat gatctccaaa agtgtcaaca 69180ctgtcccaaa ctgagcaccc cgccccacag cagagccctg ccccagcgcc tcctgttctg 69240gctctatggc aattccctct tcccagcggc cgcagcaaga gtcgggtccc ctgcgccctg 69300gcccagcccc tgccgcccct gcctggcctg gatgttggca atggtggttt cccagtgccc 69360tgcccccacc ctttccctta cccctttcag cccgttcctt actaagaagc caccgcaatg 69420ttggtgagaa agtgggtcag atgtgccaca gccttaggcc gcttcaaagt ctaaccacgt 69480cctgaaaacc ttctggtttg gttcccagct cctgctccga tctcgcctct atttgaaaac 69540caccatcccc acatcggcca cctctcagtc accccatcct ctggctcacc cccgagaccg 69600ctgccaattg gggggacccg tccatagcac ggatggcgct gcttccggca cctgcgccgc 69660ccgagggtct cctggccatg gcctgggggt gccacgcagc cgtggccacc gcatcctccc 69720tcagtgctcc ccacggctct caatgcgctc cccaagtgct gaccacgcgc gcccccacgg 69780ctccccgaca gctccgccac gccctcccca cggctctcca cgctctcccc aagtccccaa 69840cggctccccc aagcgctgcc cacgctcccc cacgactccc ccactccctc tccacgtgct 69900ccccacgtgc tcagaggagc ctggacaggt ggatccgggt tgccccgggg actcattcag 69960gggtgagcac accttgtact tttccctcgt tgtttccctc cttcccctcc tggaaatgcc 70020tcctgcggaa accactcaaa cccttgtctc aggaccatgg caggggtctc ctttcttaca 70080gggctggctg cttcctcagt caaggcttct ttggctattt acttatctaa aatgaaaact 70140ccagccatat tctcagtatt tcatagcctc cttttccatg ttgttctcat tctttaaagt 70200actacctatt tcacctactt gtagtgttct ctgtatccct ctcctaccag aatgtgacat 70260ggacggtaat gtcagccttc ttcactcctg gttaagcaga cttgagaaaa gggcctggca 70320tacagtaggc attcagtaaa tgctttgtga ctctgtcgag aggtgacagc atgctggcag 70380ccctcacagg ccttgctcgc tctcggtgcc tcctcggcct cggcgcccat tctggccgcg 70440cttgaggagc gcttcagccc gccgctgcac tgtgggagcc ccctcctggg atggctgagg 70500caggagccgg ctccctcagc ctgcggggag gtgtggaggg agaggcacgg gcgggaacca 70560gggctgggag cggcgcttgc gggccagcta gagttccggg tgggcgtggg cttggcgggc 70620cccgcactcg gagcggccgg gcagtgaggg gcttagcacc cgagccagca gctgcggagg 70680gtgcgccagg tcccccagca gtgccggccc accggcgctg cgctcgattt ctcgccgggc 70740cttagctgcc tccccgcagg gcagggctcg ggacctgcag cccgccatgc ctgagcctgc 70800ccccgcaccc ccgccgtggg ctcctggcgg cccgagcctc ccctatgagc gccgccccct 70860gctccacggc gcccagtccc aacaaccgcc caagggctga ggagtgcggg cgcacagcgt 70920gggactggca gacagctcca cctgcagccc ccgggcggga tccactgagt gaagccagct 70980gggctcttga gtctggtggg gacttggaga atctttatgt ctagctaagg gattgtaaat 71040acaccaatca gcactctgta tctagctcaa ggtttgtaaa tgcaccaatc agcactctgt 71100gtctagctga tctggtgggg acttggagaa catttatgtc tagctaaggg attgtgaata 71160caccaatcag cactctgtat ctagctcaag gtttgtaaat gcaccaatca gcaccctgtg 71220tctagctaat ctggtgggga cttggagaac ctttgtgtct agctcaggat tgtaaacgca 71280ccaatcagca ccctgtcaaa acagaccaat cagctctctg taaaacagac caatcagctc 71340tctgtaaaat gggccaatca gcaggatgtg ggtggagcca gataagggaa gaaaagcagg 71400ctctccgagc tagcggtggc aatctgttag ggtttgtgtc tgtcgtgtgg aagctttgtt 71460cattcgtctt ttgcaataaa tcttgctact gctcagtctt tgggtccaca ctgcttttat 71520gagctgtagc agtcaccacg aaggtctgca gctgcactcc tgaggctagc gagaccacga 71580acccaccggg aggagcgaac gactccagac gcgctgactt aagagctgta acagcttacc 71640gctaaggtct gcagcttcac tcctgagcca gagagaccag gaacccacct agaaggaaca 71700aactccggac atgccgcctt taagagctgt aacactcacc gccagggtcc gcagctgcat 71760tcttgaagtc agtgagacca agaacccacc aattccagac acactgtcat caaaaagtgg 71820gatatctttt taaacagaga taacattgca gaatcttgga gttggaaata gacctcagct 71880ggggtttagt cctgttttct cctcagagca gaagtcctgg gatgccgttc tggactgatt 71940gtcagttttt tctcctgtcc ttgagctatt ctaatgccag acatctgtgg ctttacacag 72000ccaggctttc agttagagaa cttggttagc tcaggtcaac aaatgctgct ctgagaacac 72060tgactcccat gtggggagac tctgcacctg gagctccggg agagccggct caggcctctt 72120cctgctatcc agggaactgc agtggcgttg gagggccttg ctggggctgg ggctggggag 72180aagggattcc aaccctactg ataattcgtt tggaaacacc gggctgtgga tttcagaagt 72240tcttgggcag cctgattacc actggcagtg agccggggac gaagccgaag ctatgagtga 72300cagacggaaa gaactggggg ctttggtgaa ccagagaaca cttagctcct ccagccctga 72360agcaggcgtc accgcagggc ttatggtcct aagagccact tagtttcctt attcattaaa 72420ctagtttaat ttgggttttc tgcatcctgg aggacaccaa gtcggtgtgc ggagggaccc 72480tgtagacacg tgtgcaaaga ataagccgac gatcatggaa tttctgatga cgccactgac 72540acgtgggatg gaggcctcct tcccagggca cccctacact catgacaatg aatcctggct 72600cttattcacc cctttggatt tcacaagcaa gtagtaagta gaaaaatagt ttcattttat 72660tttcagtaca tcaactgaat gtgctaatac ttgtatccac ttccacatgt aagaactctg 72720ttacataaat ttgagaataa tctgctcttt gctattttga ctttattttc actgcagatt 72780accaattgtc cctacaattt gcgttttata gtttacatca tcgtacactt gattttatag 72840ggaacaaaag gttctcaata attacaaaga aatgtgttga tttaacatac tccaagaatc 72900tcatgaacac agtccaaata ataattcaaa attgaaggtg gtatattggg ctaaagtgtc 72960cagcaactaa ggaactaacg atgacttaac ttttattgtc ttgggtcaca gacacataaa 73020attgactaga aaattaatcc tggtatatct tttgtatctt caacatcact atgaatattc 73080tactttttaa gtgacatgga aacattcaaa ttgagacatg gagtctgaga gtgacacggg 73140ctgctggagt ccacaccctg ttgaccaaat ccacaccttt ggtggccagc tccgttttgg 73200ttttcaaact ttaagctcca ttgtatcccc aaaatatatg aatgaaaaca aatcaattta 73260tttattttca ttttagttat ttatttgaga cagggtcttg ctctgtcgcc caggctggag 73320tgggttgttg tgatctcgcc tcattgcaac ttccatctcc tgggtttaag cgattctcct 73380gcctcagcct cctgagtagc tgagattaca ggcacggacc accttgcccg gctaattttt 73440gtactttagt agagagaggg ttttgcaatg ttggccaggc ttgtctggaa ctcctgacct 73500caagtaatcc tcctgcctca gcctcctaaa gtgctgggat tacaggcgtg agccaccaca 73560cccggcccaa gtcaacgtat ttataatatg tgaattgttt gcacacctat ttcaagcact 73620ggaaaagaaa aaaaagaaaa gaaacaggtc catgaatgag gtaagcagag ttggacccaa 73680atacttcaat gccttctcaa caatttcttc taaatggctt cccgaaatta gctctgcacg 73740acctatcttt cttggggggt ggggaagcga ttacttttta aaagccacat taaagtgtgt 73800gttctatatc acgatggcag ttaagggagg ggaggcgtct acagctgacc tggggaagtt 73860ttaatcattg aactatgcac aagtggggcc ggggcgggaa gcggcaggaa aatgaggcac 73920cttctgcaga acctagccag cctgcaggcg ttcctgatct gaggaaaaca ctttaattaa 73980tatgtaaaac agcagtgggg agaaaagcaa ggttaatttc caaaccacat cactaccagc 74040ggtatttggg ttatgaaacc ttgggaaact tctaggagat cctgtttgaa ggcacagagg 74100tgcttttgtg tgtgagtagc ttctgagatg ctcaaaagct cttttatctg ccccctgcag 74160tggtattgct ctttctgtgt ttaaaaacac tgcctttgac tggcaggctt ttgtttttaa 74220tttgcagtgc atcctccatt tttgtttgga acttgcctga aagcagcgtt taggggagag 74280agagctgttt gatttccttt gttgcggctt tcttagctgc tggctacctt tggaatgtgt 74340gacacaggcg tctctcctgg ttaggaaaat gttctgtact tgcctggggt gagactgtag 74400ctcatttcct gggttgagat ctaaaatcct gagcagagtt aagtgtatca aatagtggct 74460gtgccaagga tcagtgtctg gtggagacag cggattttcc aaggtcatgg aagtgaagaa 74520acagctgaca agtctttccc tagcttgagc agaaacagct ccattcagtg cgtgaacaat 74580taactcaatt agagaatgtg cagctttcta aagacgcgtc cactgtgagt gcgtgtgcct 74640gcgtttcctg cctccctctc ctcacagaca cctcaaaagc aacatatctg aaaagtcctc 74700ttagctaccc tgtctaggag aagtcagagg cttgaggacg atactgtgtt cctcccaccg 74760cttggtatcc caccaacacc cgctcctggc cattagacac tcaagcatct ttcaagtagg 74820gagatgactt ttttgggggt catagactcc tttgagaatt aaagtttacc ccaggaggaa 74880aataatatct gcacatacca agatcagcac acactttcag gggttttccc atacctactt 74940taagcccaat taggatttct gtactaaaat caatccctct gtcccatttc ctctgccaca 75000gccgtatgtg cagccccacg cgttacttac atctagcctg gagggttaac tttgacttcc 75060cagcttctgg cacaatttcc ttctccatcg caggccggag tggtctccac attccccaag 75120ggctcaccca tgacctttag aagaaagtcc aagcactagc ttggcactca aagtctaagg 75180aattcttcat cccgtgctcc aggcacatga aatgcctgtg ttttcgtgag caaacgtttc 75240tcctgtggcc ttccagtttc tcccagtaca tcctgtggac tatcgtggag gatttgcatt 75300gcagtgtgtg cctctcaggt ccatgttgga gtgccctgcg tccgcctccc tctgcgcggt 75360ccactcagct gggtggcgtc actggtgact gggcttctgc ctccttcctt tcactgggag 75420actcctcagt cagagtctgg gtcttcatct ctaaaccccc cggggcagca gcagtccctg 75480attttgacat aggagattag gactgcagct tgtagggagg tggtgatcca cggaggggct 75540tcttctgaag ctgacttttg tagcaagcac agtgttccaa cttacattaa atacacgtgg 75600ggtggcttga tatgacgatg gagaagatcc cacattgcac aaggtgggag ctaaagcccc 75660agtcctcgcc ctgcagctgt agtacacagc ttcacagtta cgtgcactgc cacatgtatg 75720taataatctg gtatgtaaca ggtgcttgtt gaatatttgt tggatgaata gatgagtgac 75780cctagaaaaa cacaatgcag acctatgggt agaagaagaa aagaacctgg agtttcctgg 75840aagttagggg ttccagccca cctctgtcca cagccatgtg atctcacaca cacacacaca 75900cacacacaca cctacacctg cacccatgag cctccccact ttgtcaggga tcatgattca 75960caggttatgc tgcatctcct aacttttcca tttctttgca ctcacttttt cactccattt 76020ataggcacac agcaaccccg tctcctgcaa tgacccctgc tccaggcctc acataaacca 76080cctgctatct gtactcggca gccctggtcc gaaggcaaac acagtcctgg ttgccccacc 76140tgacgcaatt gctcctagca tttcttattc actctccagc tttcgcttgg ctctaccctc 76200tgctgaaaca gctaaccctc ttgcctggca gagtcaagga aatttttgag tccagggcct 76260tcaaccttgt gtcttcagga gcctctgcaa agctgggtgc catgtaggtg ggctctctcc 76320ttccactccc tgtcgtcttc attctctagc cctccgtatc acccttctgg gcaattcttt 76380ctcagctcac ttagcgaatg taaggaagtg tttcattttc agtctttcaa atcttttttc 76440aaatacttcg tattcaatca tttcctcttc ttggatagag ttttgtgttt taagtacagt 76500gttatccaat ggctagatcc gcacctctag ccagctcacc actctgtggc ccagactctc 76560tttgccaact gtttaactct cgtgtataaa tgacaggcag ctgcatatgt ccatatgtcc 76620agctgtctgt tctgcagtgg gtcacttatg ggatcagatt gtacatctgc ctgtttcact 76680tcaaattgcc tcttctttgc aagcatccag gggtgtcttg cctcacatac aaacaaacac 76740agaacaaaac taaaaacctc aaaggaattt ctgtgttgaa gaggttttaa tggtaaaata 76800attaagttta cttgcgatta aaaaataatt gtaaattttt attaaaaaac cctcaaaact 76860atcttgctgt atttttcttt tattataatc aaagtttagg caagaagagg ggtatctatt 76920ggctcatgaa gtttaacagt tccctggatt gacctagaac agtgcttttc aaaataagca 76980tcaggcccat ctagagagct tggaaagaga tctcactgag tcagctccat cttccagagt 77040ttgtaatgca gtgagtctgg gagctgaggt tgagaattcg catttccagc aaggccatga 77100ggctgctgct gctgctttgg gggccccact ttgagaactc atagcgtcag gcaccacagg 77160acccagatgg tcaatgatat ccggagaatc aagtctcgct ttccccagtg acacagaaag 77220ttcctggcac tcccaggcta acatcctctc tggagttggt aatttccaaa agagatcttt 77280ccaacttcca taaaaacttc aaaaatatga ctctggtgct acatgagcta cctgcttacc 77340cctgggccaa tcactgatgt tccctgtggg gtaacctgat tctctggcct gggtcacatg 77400actcgccttg tggtgggcag gctcccttcg tgactgacag ctttcctgcc cgccccacat 77460tcagaatcct atctaaagca aggaatgtag ggcaaacaga gtgtttttaa agtatatttc 77520aatctctata tctatctacc tgcctacctg tctgcctacc cacctattga tctaggccag 77580ttacgtaatc tctctgaacc tcatgtttta tttatccaga taagtgattc cataatactt 77640acctttcagg ccattgtgtg gattagaaat atcacctgct tcaaacagcc agcatattgc 77700ctgcatcaac tatgtagaat aaatgatagc tagatatgaa gaggaaattg cttcatcctt 77760gaccctgtct cccccagtaa aggtggttca ttaggtgtct ggcgccagat agggtggggc 77820cagattgagg atgctcaccc tatcactttt ccccactcat ctctaactcc ttgaccagtg 77880actatgacct ctccatgcac tcatgtgtat atggaggttt tccattggaa aatgaggcat 77940atattacaga aacacccatc acatatctgt atccctttgg tgagaggtgc aggggcacgt 78000ggagtactcc ttcctgctgc taagttcatt tttgtgtggc tttcaccgtt tgttccctgt 78060tgaagccttc tccaagcttc gggtgttcac aagtctccaa gggctctgtg agattagaac 78120ttccttcctc tttcagctga taattacagc tctgtggttc tcccttgtag gtctttcctt 78180gagctccaaa acagagtttt cctgcagtgg agcttctatt cggataatta gggcactcag 78240ttgtattgga ggagggttga attaactacc tctgtctcct gtgctacttg gttctgggct 78300tctacacatc acagctacct ggaggataat catcatgata ataactatta tttactgagc 78360tgatgatgcc ctaggcaaga ttctttttcc attgcattct cccaaagcct agaaggtagc 78420tattcaattt tacagatgag gaaactaagg ctgtgtgagc taaatgcctc cgctaaaatc 78480acacagcagt acaaagcgtg gcagggtggg gaggcccgca gagttgcgac cccagcccag 78540cctgtgaatg cagactttct gtgtgaactg cgctgttctt gcagctctct ttggacctgg 78600attgaagttt tcccatgaag aactggggaa cattgaattg ttgatgttgt tgttgttgtt 78660gctctgaatt ggattacata taaattctct tttccttcaa tattcagtga gattttggca 78720gtcaatggag actcattgcc taatggttgc catgggtgat tttctcaaat cactgctccg 78780ggcccagggc catcagagca attcaccatg ctgaagagac gcctttgtta gtccaaaggc 78840aacctcaggt aatcaactgc ttgacccacc tctgatttta agcaccaaat taattttaga 78900cgttgcatag agaaaggtcg atcctcctgt tttctctggg agtggcaagt gagcagctca 78960gctggagcgc ggcagggttc tgcctgtgtc cctgtcctca ccccatctct gctttcacca 79020agcaagagct gcatttgggg ttggccgggg ctttctcacc tctggagatt cctggtccaa 79080tgtcattggc aagcacgtga cctgagagaa cctgaagatt aaaacactgg ccttcgaatt 79140ctgagaagtc ctgtcatcat ctatcaggga acttagcaat accacttctt ttcatagcag 79200atatatttat gtgcttgact tacattttaa tggtttataa aagctaaaag caatcgcagt 79260ttggggggcc ctacgtggac ttccctgcaa ttctgtgatt gtcccttaat gaagtcaaca 79320aacacaatgg gcagatgaat gaatgctccc aacctaatta aatctaacat ttgagaataa 79380aataatacta aatatgtaat ctcatttcca tttggaacca actagagctt ctttgaaatt 79440tggggctatt tggaaagcat tatagatcac aaatagatgg aaccataatg gaaacacatt 79500accgctcaag aagattgaaa atagccctcc cgtaaaccta gtgttgtatc tctgtacttg 79560tgaaggaaaa gactctactt tgacctgagt gggctctgtt gaataatatt gaaaatgcac 79620agctgaatga ggctgcatta gactgtccca gcgggagaac aaatcagaag ttatgttgtt 79680gatgcaaacc gttttgtctg gccacctttc taacgtgctt gtttttcatt ttcctctttt 79740tctgtctttt ttgggaggct ggggggtggg gtattaccta gggagagggg aagccaatca 79800ccatttgact gtgtgttgaa tttaaggacg cctagaggtg aaaagaggaa accttatgat 79860tgaattttgc ctactaatga aagttcatat aaatcaaggc tcacatagct cttatatgaa 79920taaaatatta tacctggagg caggaggatg tgatctattt tactatcttc attaatctgc 79980aaatttgctg ttcaaggctg tggccacata tcactgtgga gaaaagacat tcccttctgc 80040actgctgttt tctcaggtcc agaacatgct ctttctttag tatgacacat gtcttttttc 80100tgataatcac ctggcttcac tttttgtaag gtttacaaaa ttcattaggc atattcaggt 80160tcagaggttg gtgaagtgct tgaaccatat ctttaggtga ttactatccc gcatgctgca 80220ttttgtaatg atgatgcttt actcagttat agtcaggtca aacaagtgac aatgataaag 80280accattgtgg acgcagcaca gtcactgact ggacctacaa acacactggc agggctgtgt 80340ttgccttaca atctgggctt tataattaaa ggaaacatca gtgcttaagc ccagaccttt 80400ggtggggcag ttatcatgaa ctctggaaga ttcgatccat taaatatttt ggtttgttcc 80460aatcaagcag tgttcatgac ctactttgac aggtatttgg gatgtgcagt caggtgattt 80520ttcttttaaa ctatcttatc aaccaagcag attcttccat gtggccatct gctcagtttt 80580gcagccctca gctgttcttg gagctagaaa aaaattctcc

tgtggaaaaa tcaatgtact 80640tctctcaagg agatggagat ttaatatgtt acaggaatag atgcagtaga aattgataac 80700ccttgttata tctccatttg attgagagat cttagggtaa ataaaatatg gctcaattta 80760cagtcagatt acttaggttg ttattttaat aactaattca gtaattttag aaagtaggag 80820agtaaactta tagcattttt acactaaaat agatttcaga catccttcat gtaggtaatg 80880tcttgttgag actattttcc tggtgttttt gaaactgtgg ttctgtttgt agtttcgtaa 80940gagctttgaa tttggctcca tttggggttc agcaaattag tgtagtttgt tctggttttt 81000atttgaggtt ctgctcggga tgagtcccag gaatggatgc catgtttgtg aacagggccc 81060actttcatct gagcatgtca ataacaggaa aagccagatg ggcagcaagc ctccaccagc 81120acccccacca catctgcact catacccacc cctccgtgtt ggctccagag gtgagagctg 81180ttttctttgt tcaccatttt agggtgagcc cagtgaaagg caggcagggt gtccatcggt 81240ggatacatat ggagatcaag atgcctgact tccattccct accccagcac acctgctggc 81300gggatccagg cacacagctc tcagcactgt gtttgccctt gaaccagtga ggggtctcag 81360tcgctgactg gagggggcgg atcacgatcc agcaaggcct ctgagtgcca gacagtgtgc 81420taagccctct gtacagttag gagatccctg tggaaggtga tatcaccccc atttttatgt 81480tcaaggaaaa gcagtcccag aaaggactcg ggtttgagtc ccgcggcagt aagtgctgga 81540ggtaattcga gcgcgttttg gcttcctggc tgttctgtgc tctgtcctgt agcctccata 81600aatacaggta gttggtgacc taaagattgt aatctttagc atttttacaa gccaaacatc 81660tgtgaaaacc acagtagtat cattataaaa atcccatgta agtataaata gtatagtaaa 81720attaaataac agcaactcct cttatttgaa tatagcagta tttttaggcc aagggttgtt 81780ttggtcaaac atgatcccta tatctggaaa acctggtatt tttgggacat agtttccctt 81840attcttgctg caagaatgac tttttctgga ttaaaaaata gactatggga ctactacctt 81900gtttttctgt ttacagaagt aggctgactt acggatgtgg gggaattatt catttacgat 81960tatttcatga agccattcat cttcaggtct tccttccaat aaggaagacc tgaagttcaa 82020ttagtggctc ccttacaatc tgagcataac atgaaattta cataaatctc tacttctctt 82080ttgctttgga ttaatgaaat caaacaggca actagaatat gctgccagtg cagaatatga 82140ataaaataaa taaagtattt accccagctg tgattgttaa ttttagtgta tagtgagact 82200cctacagtgt ggtttgttat agattttttt tctttttggt tccttttttt ttttaattga 82260ggaattatgt tttctgtttt tatctctttt tttatgtgtg ttttgtggtt tatactcctg 82320gattttccta ttagttttac ccctcctaaa attctagctc atcgtactta gctatgtttc 82380aatatatgat tacagtgacc ctttaagtga acagaatgat ccctttgaac cgtggaatag 82440gtgaacgacc ttttggaata cacacagact ctggtgcaat gtagccagaa aaaccaaaca 82500aattgacagc cagatgaaaa gcgattggtt caattgaggt acacctgcca aatcagggct 82560gccagctggg aaattcttac gcattttcct aagtggctgt tacataaaat attgagcctg 82620cgtgtatctg ttaagtcatc atggctctga tatttaaaga gccttgttct tttatttttt 82680ccttcctgga atggggaatc aagagaccag ggtttacata ttgaaaacaa gaaaccaaat 82740caaacagtgg cttattcttt aaagtaaaca gagcaaaggc tatcagtggc agatgtaacc 82800aagagctggc tctatgcaga caaagaggag attatgaaaa caaaaatctc ttccactgaa 82860ataattatgt ttaattactg atccaggaac tgcatttaac gtttttcatt tgcacaaatc 82920ttaagggtaa atgaggctga caaatactaa tcaggagaca ggggagatta tttcatggtt 82980ttgggtggga tgagcatcta aaagcctatc cttctctctg gttttgccgg cctagaccct 83040acgtctccct caaagatctg ctgagaccag aactttgagc cccactcttc ggggagtgcc 83100agcccattct ttccaacctt ctttcttctg catttctgaa aaccacaaaa ttgagttatc 83160actgcggcaa caccttgtca cttggctgag ctctttctct ttagctgata acttggggga 83220acaaagcctg gttccatcca gggttcatat ttgaaaacta aataacaaaa catagaatac 83280ttgaatgaac tctattctgt cttgtatatt gtccctggca taccatctgc actgaaagct 83340gctcagaggc agggatactt catgtctctt ttttcccagc tcccagcagg atattgagtc 83400aatcgtgaat gatggatgga tgggtggatg gatgaatgga cggatggatc tgggatcgtg 83460tccaagtgat tgcactgtgg ttcttaaagt ttattcagat atttggaaca agatcataga 83520ctatctccta cagatagtaa aaaattcaat cctttagcca actggtggaa ggagatcaag 83580gctatccatc tgtaagattg ctccagagtc atgcctgatg ccatttcaca gagaatgtca 83640accctgctct tgctttactg tgcgtttccc gtggcagggc tgatctctga gaactgtgaa 83700gtagttgttg attgttgttg tttggttgtt agagtctgac ccttgttgga gtcattccgt 83760gttctaaaaa gtctccactc ttttagagaa aatcacagtg ggcaagggtt acaatggcag 83820cagaatgttt cctgatgaga tcaatgcacc cttcaaaatc ccatgactga cccttcacca 83880aaggtcctaa acagaatacc accaaggagt taaggactgt ccagtaacgc aggtattgcc 83940aattcacttc tttaccctaa aaaacaattc ttgctttgag actccatcag cagtccctgt 84000aaatattaca caaagcacta attttcttct tctacaaaag cagtaatttc tgtctccttt 84060actctttttt tatgaagttc tatggagaac tgttaaatat ttaattcctg ctgtgtatga 84120gagatcagct ctgatttcta agtacaaaac taaacttcag caagctataa gaatagtctg 84180tagtcctggt gattgacact gtgataatat atctctaaat ggtgactgtg tgaacacagt 84240attacagtct taagaaatag atttggtaca aataattatt actagcttgt gtggtatatg 84300ttgcatgtat gtgatacatg gtgtcacgtg gtgtatgtac atagaccata tatgatgtgt 84360ttatataggc gtatatatgt gtatacacac acccttttca gcctttttgg atatggtctc 84420gatttctttg caaaacatat ttattttttc atcccaagaa aatatttgtc ttgcagaagt 84480gcactggaaa tacttaggtt gttgattcaa aataattatc cttgaaaaaa gcatgatttg 84540tgttcagtct cacagcacca tttgattgct tcccatgccc tacagaacta tatttataaa 84600aggattttgt ccttttgccc tttccataac tcaccatcaa ctgtgaatca agtttcagta 84660acaatggagg ctgttttcct gaatcaacag gcaagcttta ttgctttttc tttttcaggg 84720cttctttact tgctcatttt ccagagttct gctgttctag actctcattt atattaatca 84780gtcagagtcc ctcatctgct tactgaattt gctgttgcct ggaagaattt ccaagtactc 84840ttttgcaagg aaaacaacat attttgtagt aggaagtaga agttgcccac gggccactta 84900caatccaact ttcaatcagc agcttgaatt agatatttgg agttagattt ttttgtgtgt 84960cttgtttatt ttataaaagg acattcttat ttctcatttt tgagtttaag ttggctaata 85020aatgtataat gtgactttcc taagaagtca caatattact taatatatat tactatatta 85080tatagtattt atatattata tagtattata tatattataa taagtataat aaatatttac 85140ttattatgta tttattagcc agtaaggact tctaaatggc tttctaaata aagcagattt 85200tcttttcttg tagtaaaagc aaataaaata agaccaaaaa tatttcagag tattatcaaa 85260tatccaccac acctatactc cctcagaagc ttctgtttct ccctccctgc tatcaattta 85320gttacaatgt aacctcatta aaaataggtt cctttcctct ggggcacctc gtaggatggc 85380ttcctccagg aagttcccaa aatatgggga tggatagccg gggtcatctt ctgccagctt 85440tggtctctac atgcttatac ccacttcagc caggtcccac ttcctctagg actttccgtg 85500gcttgatgcc taggctggct gggtcatcgt gaaggggcca gaacacagaa ttgcaggtag 85560gaaaaaccct aaggtttatg tgtgggtatt acctgaaggc tttgaggcag gtgcctcttc 85620tagatgatct cagtgagtct ccactccaac tctggcacag cccactgtgg caggtcttaa 85680gcttcagaga ggtttaggag ttggcctagt cgcagacagc aggtgggcaa gatgggcatg 85740actgcaggtg agcacgagcc tgcctctctg cagctttctt cctggtccca atccttctgg 85800aacagaggtt cttgccctgt cctcctatcg ctgtggtctt agacctgcag gctctcgaga 85860aggctccttt tatacatctg ctgtttacct cccgcagatg cttggagctc cattggtcac 85920ttgccccatc cctgctggag gtaaatcctt aaggctcctc atatcctgcc caccattcac 85980tcactcattc actcattcac tcttgtagcc tcttacccac ttcaagtcat ttattacatt 86040cactcactca ctcactcatt cattcttgta gcctcttacc cacttcaagt catttattac 86100attcactcac tcactcactc attcattctt gtagcctctt acccacttca agtcatttat 86160tacattcact cactcactca ctcattcatt cttgtagcct cttacccact tcaagtcatt 86220tattacattc actcactcac tcactcattc attcttgtag cctcttaccc acttcaagtc 86280atttattacg ttcactcact cactcattca ttcttgtagc ctcttcttac ccacttcaag 86340tcatttatta cgttcgaggc actaggaaag aatttcccat ttcaaagaca tgcagttttc 86400tggagtggat gacctctgct ctaaacatga tactaataat agttgttatt attacctata 86460tcaacagcag tatggattga attgtgtctc ctccaaattt atgtgatgaa atttgaaact 86520cccagcatca cataatatga ttatatttgg gggacagggt ctttagagag gtaatcaagg 86580tcactatggt tgctgtcctt agcgaaaggg gaaagttgca catagacaca agcatagagt 86640aaagacgatg tggagagact cagggagaag ataggcgtct acagccaggg agaggcctgg 86700agcagagcct ccctcacaga tgtcagaaga agccagccct gccaccacct ggatcttgga 86760cttctggccc acagaaccgt gagataatca atttctattg tttaagccac caagtctggg 86820gtactttgtt gtgacagcca tggtaatgta atacaaatag gaataatata tatatggaaa 86880tgtaggcctt cgctacgtgc aaggtatggt gaaaattgct tttagtgcag aatcttactt 86940aaatctcacc caaaccttca tattaccagc actactaaga tttaaagatt aagaaactta 87000tccaagacca gacagctagt agatgagaaa cccagggttc aaacccacac ctgtgactct 87060ggagccatca cctttaacca tcactttgtc ttattttccc ccaggctgaa aaagtccttc 87120ctactcactg gatgtgagtc ctgcgtgtcc cattgtaaac tgtccctctg cctcaaatgt 87180caacagcaac attgaaacaa cagtattttt tttttcaaat cagtataata ttcagaggac 87240attaaattaa gtaggcattc tcatattctt ggtctccaca tagcagaaaa atctgttaga 87300atgaagaagg taatctcatt agtgaggtat tacgttgacc tgaggagcaa atgctgttgt 87360tgtttctggc aacagaggat tttgtccctg aacaaaagtt agcctggcac tgtgaagtag 87420gcttttatat gaacaggtca ctccttgcaa cagcaacaag tgttgcttca gaatgagcct 87480ggctcctgcc atgtgggtca gggctgacag cagggatttc acatgtgaca gatgactaag 87540ggtttatgtg gacatggaag atttgaggct cctttctgcc cccatcctct cactgaggca 87600attgaagatc tttttctcct agcagaccta gaaattgttt gccagtgggg gcagaatgag 87660ggaggggctt tgaaactcag ttgctacaag ttagcgtgta cgtttagatg aactcatgtt 87720aacaatatac ttttccagtg gatccattcc agattaaact gtggtctttg agtttctcaa 87780cttccttttt cttattgttt gatatttatt gctttttaaa aagatttgct aatcttacac 87840gcaaaacttt cagacaaaga cttcagggaa taatctttca tacaaagatt tcaggcaata 87900aatttctagt gtttatacag ctagcgaata gaacttcttc ctaaaattgt ttgaagccca 87960aaatctaatg gcaagagatt ggctctcatt tttggtagcc ttgattgaag ccgattgatt 88020gaattgctgt tcctgtcaat cttgtgacat tcttacacta atgaggtaaa ataaatgctg 88080agtcctgagg tcacaccagt cctcgctgca catgtccttc acctgacttg atattttgaa 88140atttttatcc ataatgagaa gttgagatct atcgcccctt tttgtgtgtg tgaaaatatg 88200gctggtttta ctcattggtc tgtccttgta aacaattaca ctttctcaac aattgagatt 88260ccaaactgtg agccgaccct tgcttccaca gagagaggag atggtagaga ggcaggaagc 88320catggagtcc tgtgggataa cggcccccag aggacaaggc gacgttaaat gatggcatgc 88380atggtaccca tccaataagt tctattctag ttttccccat cgatgggctt gactatgacc 88440agggaatcat acagctttgg aacagaaaag aatcatctag ttgtggtcaa atgtcacact 88500ttttgggaga aaaacctaga ggtgagggag acacagtgac ttgttcaagg tcacataact 88560agtaaatgtc aacgctggga tgataaaccg agtcttttgg gcatgagttc agtatttttc 88620aacagaattc acatactgct atttcacaaa ttagacccag tttactaatt gttgccttat 88680gctagatctt gagaggcaac agctgtgttt gtccttatcc tttgacaccc agagcctagc 88740acggtacctg gggcacaaga gaaactcaaa tgtgtttgcc aaattaaagc actaaggaat 88800aagcacattt cctcttaatg atcactttca aaataaatct actattcatt taggaatact 88860aatagctttg acccttcact tgctcacgat tatggttgcc taaggttaaa aataaggtaa 88920ggtaatgaat gtaaattcat ctctgtctgg ctctttgtta ttggtgatag tgaaaagttt 88980catggcaaaa gaagatacaa atcaatgaaa aaaatggagt ggggagatac cttctgtctg 89040tgctgcgtgt gttccccatg atcataaatg gagaagtgga ggcaatatta acgaaatgtg 89100cacttacaaa gcctgtgctc agcaactttt gataatattt aagtccatta gggcctaccc 89160atacagtcat agatccgaag aggtcgatta aactttgaag agcttgttta gctttgttgc 89220ctccaggaag tccgtaggaa aaagtatcag aaaagcataa aacaaaaaaa agttaaaaaa 89280aaattatttc ttctatgtgg tgtggttcca agaaaggact ataacaggct tctgccctaa 89340attgatcagt gtaagctgac atttgaagat aaagcataaa tactctaaga ctgtaacata 89400ctatacccag agtagtaaga acaattaaaa ataggctcct ggggaaaaaa aagattccta 89460aaactgaaga gaaattctct ttttctatta tataagctat ataccaatgt ccctcaactt 89520atgatacagt tacatctggt atggtttggg tctgtctctc tgccaaaatc ttattgcaat 89580ccccactgtt ggaagagggg cctggtggga ggctattgga tcatgggggt ggatcttccc 89640cttgctgttc ttgtgacagt gagttctggt tgttgaaaag tgtgtggcac ctcccgcttc 89700actctcttcc tcctgctcca gccatgtgcc tgcttcccct tcgcccgcac atgattgaaa 89760gtttcctgag gcctcctgag ccgtgcttcc tggagagcct gtggaactgt gagtcaatta 89820aacctctttt gtttataaat tatccagtct caggtatttc tttatagcag tatgagaatg 89880gactaataca cattcctata aacccattgt aaactaaaaa tgtaagtcga aaatgcattg 89940aatacaccta ccaaacgtca tagcttagcc tagcctaccg taaacgtgtt cggaatactt 90000aacattagcc tacagttggg caaaaccacc tcacacaaag cctgttttat aataatgagt 90060tgaatatctc atataattga ctgaacagcc tcttgaaaat gaaacacgga atggttattt 90120cagctctgga aatacagttt ccactggatg tgtgttgctt ttgtgccatt gttaagtcaa 90180aaaatcctaa ggcagggcac atctgggttt tttttttttt tttttttttt gagaaggagc 90240ttcacaccat cgcccaggct ggagtgcagt ggcgccatct cagctcactg caacctccgc 90300ttcccgggtt caagagattc tcctgcctca gcctcctgag tagctgggac tacaggtgcc 90360cgccaccatg cccgactaat ttttgtatgt gttagctaga gattgtagct gtgtgagtgt 90420ggtttatttc atacggaaca gaaatgtttc ttttagtaga gacagggttt caccatgttg 90480gccaggctgg tctcgaactc ccgaccttgt gatctgccct tctcggcctc ccaaagtatt 90540gagattacag gcgtgagcca ccgtgcctgg cccatctggg gttttttgta gtgtatctta 90600gttgcaatct agaagaatct gatgagtttt cactgtgtag gcttattaag acttgctata 90660tttttactgt gtcctttacc ttcttaaaat gcatttataa tttaaaaagt ctgatctcat 90720gtatataaac aatcctcaga aataatttga atatgttcta agtaaagtta ataattttca 90780attatacaaa ggccaatagt gggtttattt tgtttgtatt ccatgcagac ttaagttgct 90840tgcaagataa tctgggaaat tgtaggcttt ttggtggtgt tatagaatcc agaatttggg 90900agtctccact gtagaccaaa tgctctggag tacgtgaaat ttgtctatca gcaaatcaac 90960agactagtta acctttctcc aggcagtgtc tcccctccag ccctcaggca ttttgcctaa 91020atcccatttc tttttctctg ccggctgtct gctaatccct cggaaagtgt tagctgataa 91080cttaaggtgt gaccactctc aggagtattg catttcaaaa gaggcctcca agatagaaaa 91140tacttcactt aaaggagcta gacaaggaag gaaggttgtt attttttaac ctgcttgtaa 91200gttgagttcc aggccattta actcagtctt tagcgagatc ctctgtgagc ttccccactg 91260catgaatttc cctccaattc tgagagccag tgactctgga cggcacttcc tcacttgaaa 91320gcatcacatc acaatcattt cggcctaaaa cttattactc atctgtgtta gctagagatt 91380gtagctgcgt aaatgtggct tatttcatcc agaacagaaa cattaaaacg attcgactcc 91440tgcaggacat cttaatagtg tgtgaaagga agaattcata tttccagaac tctgtacctg 91500ttacagctca ggcggtctat gctttcataa acatagtgac atattttatg cattgatctt 91560aaaaccctat tacaaattct attccatatt ttcttagaca tttggacaca cttaaagctg 91620aagcaaccat gtgtcagggt tcgctcatta aggttttctg ctcaaatctg tatgaacaat 91680gtatagatga catataccta tatatgtaaa tatgtatata gattatgcca gtatcttcca 91740tttattctca tataattaga gttataacaa caatgattta tatgttcaaa agcaaacatt 91800tattgagttt attctgtggt cagcggatac tagacattag atgtgcagat agaaatgtat 91860atagttcagg gcccggtgca gtggctcatg cctgtaagcc cagcacttcg ggaggccgag 91920gcaggcagat cacgatgtca ggagatcaag accatcctgg acaacgtggt gaaacccagt 91980ctctactgaa aatacaaaaa ttagctggtg tggtggcgct cgcctgtaat cccagctact 92040tgggaggctg aggcaggaga atcgcttgaa cccgggaggc agaagttgca gagagccaag 92100attgcgccac tgcactccag cctgggcgac agaatgagac ttcatctcca aaaaagaaaa 92160aaaaaaaata acagagcttt aggttatgag gggttttgtc tcctcatccc atttcagttt 92220ttctgaaaaa gtgaagacac ttaactatgc tcacaatttc aggaaatatg ctcagttttc 92280agtttcttca gctcttacag ttacaactat ctaatcttta tttgggttgg tcaaagactg 92340cagccaacaa tctgagaata tgcttcctaa agtggctttg tcttgtatat ttaattgagg 92400aaggtatatt ttatattcac acatgcacat gtgacttcta tcttcagata tcaatggtca 92460aacttaggaa gtgcagcaga ggtgaaggag tagtcagctt tcttcccact tgctcttgca 92520aattggttgt gatctgtacc catgggtaaa catctatttt ggcacacata caaaaataaa 92580atcagaatct agagttggta aaatttgatg aatgattcct agtaatttag ttttcactta 92640caactctaga aattttttaa atcttttctg cataacaata ttgtttttta agttttgggt 92700ataaaaaaat gacattctcc ctgaaacaag caggcagctc tccattcagc agaaagttat 92760gcaataagat ataagggatt gcagagacgt tctccatcct cctctctctc tctcccttct 92820aaggggaaaa cctcctaagt taccttgggc aggtgcctac atttggtact cctggacagc 92880tcagccatct gccaagaaac aattctatat agatgcctga cctgctcagt tcagaaggag 92940ttttcttctg actgctgcta aataagccga ctgaatgata catttatttg ttaatggata 93000ctcttttttg gctctcaatt taaaaacatt ttttaatggg caattgaaaa atatacagat 93060gaagaggcca tggtctaatg agaagccatg gagtcatcac ccagcttcag cagctataaa 93120ctcaggatca gtcttgtttc acctagagct acagtagaga aacaaagtgt ttggaaaact 93180ggagaatcaa caatcttggt gagcagtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 93240tgtgagagag agaaatctgt aggtttgggg ctttattgtt tttcctaata tgtaatatag 93300cttgtgcatc catataatat tattattgga agtatggctc caaaaaattt taggcctata 93360ttttaatttt aaacttaatg actaaatgtg tatattttca agatatcaga tatccacatg 93420taaacaaaaa atacggtcaa ctttctggaa gttcatatct ctagatagct atctctgtgt 93480ggataaaaca tctagtttat gtttaacaat gaatgaagaa tgggctctgg tcatagctga 93540acagggaacc tggggtttgg ccacttcagg gtgacctcag gcaagtcatt aaatcagtta 93600cttgggttta tactttcctg tttctttcat ttatttatta aacatatatt gagtggatta 93660ctttctacca ggcactgcag agaacaaaac aaataaatcg cctttctaga tataaagtgg 93720ctccagtcca gaggggatga gagtagaggc tggatattct gtccctaacc tttttggcac 93780cagggactgg tttcatggaa gacaactgtt ccacagacca ctgggggtgg ggagatggtt 93840ttgggatgat tcaagtgcgt gctttatttt tattattatt atatcgtaat atataatgac 93900ataattatac aagtcaccgt aatgtagaat cagtgggagc cctgagcttg ttttcctgca 93960actagacagt cccatctggg gatgatggga gacagtgaca gatcatcagg cattagattc 94020tcataaggag tgcacaacct agatccctcg catgcacagg tcacaatagt gtttgtgctc 94080caatgttcct gaatctaatg caagtgctga tctgacagga ggcggagctt aggtggtaat 94140gctccccgtg gcttgtggct catcttctgc ggtgcagcca gttcctaaca ggccatggac 94200ctggtaccag tccatgccct ggagctcgcg gacccctgct ctaaagctac ttccggcgct 94260ggtagtatgt ttttaattat ttcttttatg ttaattttat tttccaaata attccctatt 94320ctccaataat tacaggataa aacctttagt ctaatatttg agatttacca cactgttgtt 94380caaatctgcc ttcccaactt acaattctac ttctcccctg ctaaaattat tctctctagt 94440tacaatgagt tgtggacagg aagtttgctt cattcatctt tgtatccaca atacctaaca 94500taatatctga cccagtgtag atgctcaata aatgattaat gagtagtaga taaatggaag 94560cctcagtcta tctcctttct tgtcttataa tattatacct tgagtatgtg gaaaaaagta 94620ctgaaaatct ttgattcttt caaggtgccc agggtatgat ttatctagag gatcttgaat 94680taatagctag atttcatttc caatttatga aacagatttc agggtctttc aggaactaat 94740aatttttgaa aattacttac tcagcttcca aaggttttat cagtcatgat aaaggtatac 94800tatgatactt gctgattaca tacaatttca agtatttaga tgtttggaaa tacgtggatg 94860ttattagtac tatgtacata aaatttgttt ttgaatgtcc ttacaatctt gatagttctt 94920tagaagaaaa tttaaaatga ttttactaac tctgcttcat ctaacataaa atcctgaaaa 94980cctcaaatga tagtactcct tgtgcctaga gctgctggaa agcacctctg aagcactgtc 95040atggagtttg tgtttttcga accttataat gaacagcgaa gtgggaagtt tccaggctta 95100ggtgttcttt cacgaggagg aagttgggtt taacacccgt cttagtagtg ctgtacagag 95160agcaataaac aagccataat gtggtttatt tgggttaacc tattagccat gtaacctaaa 95220agcttgaacc acatggaaaa tagacatgat gaggtgagaa gcaaatatga caaccaagaa 95280aagacaggga ttgtgacagc cgcagtgatg gacggcgggc cttgaaacac agtgaggtgg 95340cccgaagctg gccccgctgg gcctcaggct cccggcccag cctcttgggg cttttgtttc 95400ctcttccatg aagcagagga ttgtgccgat tgctctgcgc cttcatatgt gtgaagctcc 95460catgtcagtg cctggcacat ggctggtggg atatgttttc ttttattact gtacaaatga 95520atttgataac aggctggtta ctcagagcca gctttgtgac accttacttg tctgtatatt 95580ttgctctttg ttcagttcat tcattcatcc atagataaac attttaaata actattcaat 95640tgcatatcat gaatatttat tatctgctct gtaacagcag

tgtgtgaggt gctacatctt 95700ttatgtaaga tctggagagt gactctcccc acctgggctc cgtaggttat gggagggtca 95760ggcacagcac tcccaccaag ctatctgctg gggcatgagc tggggtaacc tcgaggagag 95820gcccctgctc taaagtacac acctaccatg tggctgtcat tctgctcaca gtcgcccctc 95880cctgctggcc tgggagtttg ctgctcacct gctgtgacag tcaccaagct ggccatgctc 95940cctgggaaac agggaaggga ggagacactc ccatcctgtc ctcactgcct ccagcctaga 96000gaagggctct gaagacgacg gggctctgag gatgtgatcc cacgtgtcct cgtcctgagc 96060agatgttcta ttcgtgtcca actgcagcct cccttcccat gacacacaga cgtacacaga 96120tatcctgaaa tcagcattgc ctttgtatcc caacatggag atccttgcct gcaataatgt 96180ctcgcttttt tcttcaatca ctggaacctg acttttcttc tgaaccacgc tatgtgtcca 96240tgaacttctc aagaggttct ccaccttcct ctgcaacggc tcagctccac tcccaggcct 96300ctcttgagaa tttccgcacc agctgcagcg tgcccccctc ctctctgtga atttctcctg 96360tgacaagatg cctatcgctt tgctttgcat caggttgcat catatgatgt cagaaaagct 96420gaaagaaaac aaagtgctgt ccctggggag tggggcactc acaacacaga aaggagcctt 96480ggggaggggc cgcgcttggg tttcacctgc agaacaccca cttctggctt caagtaacca 96540ttctttagtc ccacattcta tattgccatt tgtttttcat gagcattaaa aacgcattct 96600tagttcttag gtgttttctg ggactcagag ttcattctgc tgtttcattc aaggttcagt 96660acacttcttg attttatgtc cattgtattc caaggataga tgattaaaat atcatcaaca 96720atctagggca ctttgtgaaa accttcaccc cagaactctt atccactgat gactctcctg 96780gtctgctaaa aactcactta ttgtgaaaga ctttcctggg atcaaatgtt ttgaaataaa 96840aatttatatg taaagaaaca ttgttttgtt taaaacagag gtaacagtat gacttgaatt 96900ttattcgttt cttaatcatg attttttttt ctaatgatga cctttgatta aattgtataa 96960aaggaccttg aaattgaatt gacacatctt ctccggtgag accttggtcc agctgctaag 97020gtaggatttc tgacagtgcc ggctgtccag tggaactggc tgacaccttt tctcagagga 97080caaggcacag ctgtgaggtt ctttggagga actgtgcgcc tgccccattg ccagtgtggg 97140gcccggtcca caggaaggcg cccctaatgt gctcagcgtg tgtgaagatc agaagcacac 97200agatgcaaac atgggttagt aagtcacaca ccgtaactga ctcgaactca cagctctaaa 97260acaagagtaa agaagatgaa attcatccag ttttgtcacc acctgtgcat ttccaccaga 97320gaggaaacca ggcagttgtg aaatcgaagg ggctgggctg cccactcctg gcccacaggc 97380ccccctaccc tgagggaggt cctcaaggca aaggacagga agcggtgggg ttgggagctc 97440tgtctgatgc tctgttctcc caaaataatg tagacttttc cactggattt gaggacgtgt 97500tctcaagtgc atttcaggct tgggacaact ggaggcagtg ttggtggaca gctaaggagg 97560gtgcaggaga atcactcagt ggaggaccct cattttgctt gctttggctc tgagcatgtc 97620tgggagaatt tttttttttt tttttgagat ggagtctcac tctgtcaccc aggctggagt 97680gcagtggcac gatctcagct cactgtaacc tccaactccc gggttcaact gattctcctg 97740cctcctgagt agctgggatt acaggcgtgc gccaccacac ctagctaatt tttggatttt 97800tagtagagac ggggtttcac catgttggct aggacggtcg caatctcatg acctcgtgac 97860ccgcccgcct cagcctcccc aagtgctggg attacaggtg taagccaccg tgccaggcct 97920tctgggagaa ttaaattcca cagttgaggg tggggccgct tggaagaagg tggggtaacg 97980caggaaggga gccgggattc ggtccttggg cagagctggc acctggggct cacaaccctt 98040gcctccttca gcctgtggat catgagtgcg tcagctgaaa ggggcatgaa accaacccta 98100gcaggcatca gattttgtaa tcttatgtgc tctgtgccag agctgccgca acagtatccg 98160ctgccggccc ctcccatttt tcctctcctt ccctttagag cagggagaca tggccacgcc 98220tgacaaacgc aagccttccc tgccctgcca aagcccactg tctggcatct ccttatgcct 98280cttgttctct ctccgttctg cagccctgtg ggctttcttc agttgtttaa acacagatgc 98340tcctgtggcc tctggctatt tgcagacacc attcattttg cccggaaaga aaattaactt 98400cctcttccac caggtgcttc ctatggttct tcaaaactca cctcgagcat tactccttca 98460ggaatctttt tttttcagtt tcaaagtagg caaatattct ctttggtgat gtcaccgtgc 98520catgtacttc tcgagttgtt acgaaatagg gcaaacagtt ttgagataca ctgatgtaat 98580tttatgcttt gcatttcccg gtatatgggc ttctcctacg caacctgggc agcctcctgc 98640cctacaggga ggagggtgac ctgccaggat gcagacagcg ggtttactca tacggggaag 98700gatgggcagg ttctgcatgc taatgaagct atctgagttc acagaaacac acgaggcccg 98760aaggccaagc tttgtagaga aagaaaaata tttcccagtt tgggaagctc cctttttggc 98820atattcaaag ctaggcaaag tgtaattgat catagagttt tgtgtctgga aggtgtggtg 98880gaacagaaag agaagaggga tggcctgtcg ggtgccacac catggggcag ggaaggcaaa 98940gcagagtgta aagcagcaca gtgccaggtc ctgtccacgc caagtgtggg gccttctcct 99000caaggttgat gggcaggatg tggggtgagg gtgggagtgc atggcaaaaa tccagaaaga 99060tggagggtcg cctgtcaagg gcagaggggc agtgcacaaa tacggccttg taggatgccc 99120ctgctccggc acttcagggt ggtcttctca cagtgctagt gactgcacag ctcaaatagg 99180tagagtgagg atctgagctt gctgtccttg tcactgtggc atggaaagca tcaagacatt 99240cccacaggta catggagggc atggaaggag gctgagaaca ttccagaggt catctctgtg 99300gcaaagggtg cctgtacctg gaacccaaca gaagtcactg acaacctcag ggggtccatg 99360gggccagtga gagtaagacc cagtgggcac gaggaatggc tggtggttcc caggaaaaca 99420gcctgaagcg aaacagaaca gctgttcagt caccacaagg tgtagttgtg aatggcaggg 99480aagcattagg aggggtcttc aaagtggctg ggattgacgg tttggcaacc tggaagcgtt 99540atggaaagct tggagcccga agagagagag agcacatgtt ggtgggtagc atgttcatag 99600tgaccggctc tgtgttcaga tatacattag caacttggat ctaccacatg caaagtagat 99660aacaataggt atgtttttaa aactctgtga ttctcaattt gctcattggt agaaagtcat 99720ttagttgtga aaatttaata aagtaagtaa agcagagaga acagtgccct tggatagaaa 99780gcacacagat ttgcattgtt gtcctgctgt tagtattttt agaaggtaag cttcaagatg 99840gcaactcata tgtatctttt tcaccaaagg gttttcagtg gctagtacaa ttccatgatg 99900taatagagac tttacaaaat attcctggag caaatgtata aatgaacgat ttgaagcctt 99960aagttagatc agggtgattt attttttaaa atgtcatata cctgtgttaa tagcagtgaa 100020tgatgccaaa agtaatatgt gtgtgtgttt cagaactctt atcaagaaga tcactcatga 100080taatatacag taaatataaa tgggtcaaac ttcctttaca aaagatattg tcatattaaa 100140ttttatatac acatacatgt gtacgaagca aaatgacata gaaaatagat gagtaaattc 100200ttaaatgtaa gacaaaaaat aaaatgaacc ccaaagtgca atattaatat catacaaagt 100260ggaacttgag agaaaataag gaatgagcga gggctacttt atattaattt tctaaagtat 100320aatttattat gagaatgtag tagccagaga tgtttaaaaa ccaaataaca gcatcaaaag 100380acataaaagt tgttataaat gcaataagaa actggcaaag cacagtctta acaggctact 100440taacaatatc tctacttttt atgttatgta cataaacttt acagagaact gaataattaa 100500tatgttttat ttactcagta tttctttaaa gaaaatgtct tcaaatgtgc atcgtatagt 100560taaacattga ttatagcttc tgtgtcaaaa aaaagctcaa tacaaagcat tcccataagc 100620catattttga caataaacaa tagaatttaa gtaataaaaa gtttaacacc aaatctaaaa 100680ccatgtggaa actaaaaata ctccctgaat aatccatgag ctgttaactc aaagaaaatg 100740atagagaaaa ttaaaactga ataaagagat tgtttagaag atgccataat atatggaatg 100800taacccacat tgtgctagga gaaaactttg taagttttca aggtttttat aagaaagttg 100860caaatgaaat atccatgtta ctgcagaagc aaaaaataat ttaaaaagcc ccaacaaaag 100920catgagtaag aaaacgaaga tatagtagaa attaatgact tagaacctga aaaactataa 100980caaatatagt aattcaaacc tttattcttt gatattaaat actactgatg acaaatcttt 101040ggaaggctaa gagaaaagca gagaacatac aaatattcag cattagaatt caggacactg 101100gggagaggca tagtggtgag agcagtccct tagccgaggc acactgggtt gacttcaccg 101160gtactcagct gtgtgatcca ggaacgctgt ccagccttct tgtctcatgc cttggattcc 101220cacggctcat agtgctgtta aaaaaattac attgagttac catttgtgat atggtttggc 101280tgtgtcccca cccaaatctc atcttgaatt cccacatgtt gtgggaggga cccagtggga 101340ggtaattgaa tcatgggggc aggtctttcc catgctgttc tcgtgatagt gagtaagtct 101400cacaagatct gatggtttta taaagaggag ttctcctgca ccagatcgat ctctctgcct 101460gctgccatcc gaggtgtgac ttgctcctct ttatcttccg ccatgattgt gaggcctccc 101520cagccgtgtg gaactgtaag tccattaaat ctctttcttc cgtaaattgc ccagtctcca 101580gtatgtcttt atcagcagtg tgaaaactga ctaatacaat ttgtcgagta cttttataac 101640agggtttcaa aaagaaaata tgtatgtgtt tcttatgtaa aacaagcaat atggaaagga 101700ggttgcagtc cacagccatg agataatcca ttttgatatc tagctgaaat gaatgaattt 101760ctaggaaaat atattaccaa atatgactta agaagagaca gaaaacttaa tttgtcagtg 101820ctacaggaga tactgaagaa agtttgaata gagctatact tctgatggta gaaaggcata 101880tattttgcat tcacgcattc atttaacaaa tattgattaa ttacctacta tgtgcctgat 101940gctgctttta ttccactaaa agtacgataa tttttttaat ttcaaaagaa atttatactc 102000tgttaaaaaa tgagagtatc aagtggtgaa gattaaaagc aaacatcttc acctcctcta 102060ctccccaatc tcagctgtct gctacgtatt ctagatattt ttaaattcct ctctctctac 102120ctacctacct acctattatc tatctatctg cctatttgtc tagttgtgcc tgtgtatgtg 102180tatttaagct cagtaggatc ctattatcca tttgttttgc aacttgtttt tcatgtgatg 102240gatgtccctc cacgtcagca catggtatta taattatgca tattttattc tctttgaaac 102300aaggtgaata aataaacctg tagcaaggga aacgctatct gtcaccaaaa ctcccactac 102360tcgaagcgtg acctaaggcc aagatctgcg ggaccttttt cacaaccttt gtgcgtcttc 102420ttagcttctg atggcagcca ctggttccta cacagcatgt tgtccccttc tgtgttgtgg 102480gagcttttag agtttttctt ttattttggg gtctataagt tttatcaggg gacctgtggg 102540tggacacaca gccctcagtg gatcactgta taaggaactt cagctccaga aaagaggctt 102600caatcatttc tcctagtatt tctttctaat atttttgttc tctatttgta aaagtctcta 102660ttagtttgac cctcctgaat atatcttgca agacttttag gtttttattc attcgtctgt 102720ttatttttcc ttttagatct gggaggtttc tttggctcga ccctctagct gcctggtctc 102780catggtggaa cagcccctct tctggacagc cagcttggca gttccattta attttcattt 102840tgtcagttaa attttattta ccatacctct tcctttttcg taagtgctgt tatcttctta 102900ttccctgttc cttaccctcc ctacctcctc ctcctcctaa ttgtagctaa ttctaatttt 102960atgggtgcaa tttcctctct aatctctcag tatcaagttg gatttttatt attattatta 103020cttctatttc ctctcaggtg agctgtttta tttgttcaca ttatcctcca ccctggtatt 103080tgcctcctgt attgggtggc acttgatttg gttctttttt atgaatgaag atggggttga 103140ttgcttgtgg gtttcctttg cagccaggca catctgtttc ctgctcagcc tcctccctgc 103200ctggctaact acaggcctgt gtctgtggat gaggctccaa cagcaggaag aactatccag 103260cagcctgggg acctcctcct gcccacgccc ctcctgggcc agctgccaag ccaggagggt 103320ttttctttcc tgagagccga taactacagc acagagactt cctcgctttc ttggttcaag 103380tctctatcat tgtttcagta atttttttac agtggcccta ggccagagca acttcttaac 103440agttctgtgt ataagtagtt agagccaaac gacataatta tgcatgccct aacaacttag 103500taactgtttg aaaaaccaat acatatacct ttaaagaaaa aacaaacaaa aacaaaacaa 103560aacaaaaaac aacccatctt ttcttttgct ctgaaattcc catcacttag cagcgctgca 103620cgcgcctgct ggggacagca cagcctcacc taccttggca tgagattgga gagccctgct 103680gcgttttctg ttccctgctg gttttcatac ggggcctgct ttttatcaga gcacctgctg 103740aacatccagc cagggcctcg tggaaagtaa agtagcgctc ttgagccttg gatcggtggc 103800tttgctagag cagacgtttc atggaggggc tgatggatgt ccaagaggtt gtgtttctct 103860caaaaatgaa gaaactccac agcgcccctg tgggtttgcc ggggcgaaga tctgctgtgc 103920ttcttttagg ccctgtaagt tcaccgacaa attaattttc tttaaaaact agtctttggg 103980ctttgtcttt gggagaaaca atttctccga ccgtcatttt tcgactctat tttgggggat 104040tggtggtagg agctgtagtg agccgttcca gctctcgccc taatgtttga ctcatggcaa 104100ggtctttgcc tccttgactt tgctctcaga gctttttcta ggcttgcttg ggaagaagct 104160ttcaacattt ctattccatg gctattttca tttttctctt ttccagtaat gttatgtttt 104220catttatatg tattattttt ctcaaaagta acttgaggaa tagaaaaatt ggagccaagc 104280cagctcctcc atcagccatt tgaatttgct tgagcttcta tattgggctg gacatcagtt 104340ttaattctta aaattttatt tgaattagaa tggtgaactt tgaatcatac tgactctttg 104400tggattccac attttatgtt gtcagttatt atccagctct acttgaattc taaatcacaa 104460aacaaaacta ttcaaaccat catggtttct gcacttttaa tgtaagtatt tgaggttcaa 104520agttagctaa tcatacaata tattccagag ttagtgagaa tggacactga aaaattactc 104580ttttctggga taaggatgac taagaaccac agggaacaga gttcctctaa aatgagttgt 104640tttcaaacgg aaataaaaaa accacaaaac attgcagaat tgctcatttt atcagatggc 104700tgaaacttac atttgtaaaa atgcagtttg attgattatg atggctaagc cagggtttgt 104760tgaccttgaa gaataaaagc ttggcacata cttattggaa agtgtgagcg acatgaaaaa 104820gatataacga gaaatctttt aaatttttgc aataggactc aagaaataaa agatgtcata 104880tcaacacaag gtaaggcttt gcctagcagc cacttggtgt ggaatattta caaattgttg 104940acagttgtat actttaatac gtatgtgcct ttccaaaata tgaaggtatc agaattttag 105000atgaggtaga atatttttca tacttcttct tttagtatgt cacagaaaca agttatttga 105060tattatctct tttatatgta tagtacatcc atggatagca accacagtag gaagtaaaat 105120taccagcaaa actcttgcca gggattgtaa ttagttatta aaaaataatg tctccctacc 105180ccatattctc ctcctgagtg tattttgggt ttttcttcca ctgccaaagc cttaaagcaa 105240atgtctagac aaacctccta cactctgata atttcaaacc tgctgatttc gagtgataga 105300cctacatctt gatgtcattc tatgaatggc aaggcctgaa tttccaaagg ctctctggac 105360atctgggcag tcatcagaac tcaccgtgcc ctaatctgat gggccttcct tccctgctgc 105420cttttctcct gtatttcaca tttgagctgc tgataactgc agctgtccca gctgccgggt 105480aggaacgtca gcctctcccg cgggacgtca atccctagca cggacctgtc tgacccttcc 105540cctataccac gtcctcttgc ttctccctct gaaatatctc ccaaatcctt ctctctgcct 105600tcttttccta ctctcctcac tcacatgact gcctcgggcc ccattttcct tcacttggat 105660ctttttgtga tggtctcttt acaaagacac tgttgctgga acccctttcc agaagctgag 105720gtagaatcat accgctcctc tagaacctca gacactctca gtgcatttaa agacataccc 105780aaattctggc aacatgacac aagtctgcac cctgtcctgc ctcatcttcc acttatttat 105840gagctgtgtg tcactgagct ttccaaaata taccttttgt tttcacagcc cattcttctc 105900ttatcctgaa atgaacttct cttctatgcc tctgacacct actcacgtat gaatgtcctg 105960ctaacacacc acttccgcca ggacccaagt ttgctcatga accctcttgc ccattccagt 106020ggctacttca gaactcgcca gatctttctc tcgttcccat gttattgatc tgccgtcttt 106080gtttgctttt cacactcctt ctcttatcca agaaagattt tcacagcatc acactcattt 106140aaatgtctat agctttagtt ctagactagt ttatcttctt gctatatttt tagagacaaa 106200tttccatcca aatttactat gcaaaataaa attcttaagg aatctctaaa tcagaaagca 106260attttggcat gtttgcattg tgtatttttt ttattaactg agatttactc agaaagaatc 106320aaatgagcca aaaatttgga gctgaaatgc ttgacattta acccttctgg aaagaataat 106380gttggtctta caatgaatta attgtacatt tttgaaacgt gtaagatttt taaaaagtta 106440tatgttctag ttgttaagcc attagaaagt ttgggtaagt ggcccctttt gtaggaaatc 106500ctgtgtgcct cacagtctct ccatagcctg gtgagtagca agtgagaaat attttgcaat 106560agaaaacaga aaagtcaagg ctgaggaaaa atagaatttc caccacaaat atctgataaa 106620tttatctagg agccaaattt ggggagctat atgggtagtt caaaatctgt ttgtattctc 106680ctactggaca gaaagaggaa agtaaatgga ttaatcaggt agattggcat ctactgatgt 106740aagcaacagg tagataaatg ggatgaatcc agtcatcctg gttcttactt ttctgtgttg 106800ggatagaaga tggttttctc tcataagtgg atgtaaggga aactggtggg gataatgtgt 106860tgattgaaat ttaaattttc ttatggaaga cttgttgaag aattcaattg ttttattcca 106920acaatctggc agtttggatg cctgccatag ccttaccgtg cattagctgt gttacctcaa 106980acaaaccagc tagtcttcct tggcctcagt ttccttagct attgaatgag ggtttggact 107040gggcgatcac atagatctct tttggtggcc aaatcctgtg gctttgtgat tctgtgtaca 107100gcccagttgc ttattctgtg cagttagacg atagcatcca gactcatgca ctaggggtgg 107160aaaccgttga ctcctttctt ctttcttcct ttagtttctg aagcactcct ctgtgactac 107220acattatcag tttcttcttt ctctctatat gtttttttct ttttttccag ataatgcagt 107280tccccttgac tctaatccca aactgctttt ttcctccctg accctacata cagttcatcc 107340aagacaactt catctgtaca catgcattca actaccatac tgttactatt agcttggggc 107400tctttccgga gcttcagact cctgtcttcc acccccatgg acatctttgc ttcaatgccc 107460tgtgagtgtc tctaactcac tatgtacaga gctgaattca ttatctgttg cccttaattg 107520atctttcttg ccatggaata ctaattgact tccttctctt ccatgtaacc acctccaatc 107580catcttcaat ctgtcaacag aatgatccta ctaaaaccca gatctaatca tgtctgtctc 107640atgaggaaaa atttttagtt tccctattgc ctccagaatg catttgaaac ctctttctag 107700ctctgtacag ccctgccacc tgcttcttga gtctttatgc actactgcat gggcccttca 107760gccattcagt aaaattgact tttttctttt tagtgcatag gtctatcaat tttgactcat 107820atatagattt gcgtgatcac taccacaatc aggttacaaa caattccctc acccccaaaa 107880ctccttgggg ctatcccttt ataggctcac cctcctgaat tctgacgcca gcacccacta 107940ttctgtcctg catcactgcc gatgtatctt tccaatgctg tcataccagt gcaatcatac 108000ggccctcacc tattgaggtc agcttcatta gctcaccgta atgcctgtaa aatccatcta 108060agttgttgat tcatgtttgt cccttgctgg gttgtattcc attgtgtgga ggagccacag 108120ctgattattc actcactttt ggaggggcat tttagctgtt tccagtttgg gacaattatg 108180aacagagctg caacaaacat tcatgtacag gtttttgtgt gaagacatat tttcatttat 108240ctgggataaa tacccaggag cagaattgtt gagtcatgtg gtaagggcat gtttaccttg 108300ataagagcct gtgaaaccat ttttgagagt ggatgcttgt attttttaaa caagattcat 108360agttgactct gaggcccagc caggtttggg agccagagcc ggaataatca cttacatgtt 108420ggtcgttcgc acacactaca ggttgcttaa caggactctg tgcctgcatg tttgtgtcat 108480ctctgcaacc tcaaagccta gtgaagattt catcttaact tgattgctat gtgtttgcat 108540agttgaataa ctaagagaga gtgctcacag cgtggctgct cccactaagg tgtagtcaga 108600acatgtgata tacagtacag atgattttcc acacttctct cctgcacgta acaaaattac 108660ttttagtaat gatcatgtaa gactcagtag tagtaatgac tttctttaat attatttatt 108720aaatatttta ttataatatt tatatttata taatatatat ttatatttat ataatatata 108780tttatattta tataatatat atttatataa tatatattta tatttatata atatatattt 108840atataatata tatttatatt tatataatat atattatata atatataata tatattatat 108900aatatatatt tatatttata taatatatat tatataatat atatttatat tatataatat 108960atattatata atatatattt atatttatat aatatatatt atataatata tatttatatt 109020tatattatat atatttatat aatatatatt tatatttata taatatatat ttatatttat 109080atatttatat ttatttatat ttatatatat tatatattaa atatatgtta tatataacta 109140tatattatat attaaatata tgttatatat aacatatata ttaaatatat attatataac 109200tatatattat gtattaaata tatatattat ataactatat attatgtatt aaatatatat 109260attatatatt gtatattaaa tatatattat acataactta tatatgatat atatatatta 109320tatattatat atgaaatata tattatatat aactatatat tatatattat atatgaaata 109380tatattatat ataactatat attatatata actattatat ataatatata ttatatatta 109440aatatatatt atatattata tattatatat aaatttatat ttatatatat tatatattta 109500tatttctttt aatattaaaa tgagtagaaa tcagttaaaa ttatacattt ctatttttaa 109560aaaaattttt cagattcagt aaaatgtttt atgaactgac atttgcattt actaaacaaa 109620aatattacat tgtgcagttt gtcccctgtt gcactgtttt agattttaag cacaaacttc 109680caaatggtcc cctctgatga ctgaattaaa ataagtcaag ttgtgttcct ttattttgac 109740aggcactgtc ctgtcacgtt taatttagaa tctaaggttt aagtgcgaga atatgtatta 109800tccccggggt tggagaagca cctggaacca gtgttaatag tttactccat ccagctcctt 109860ccgttcacat gaaggcgggg ggctgggtgc ctgtgtgcca gggtcagctg aataacttgg 109920agttttctgg aataactttc ctgtagagta tgatgtttat taagtgataa agatacaaat 109980gaattgattg aagcttgcat aggtgtataa gtttcgccag actgctgtca caaatgacca 110040caaactgtgt ggcttaaaat aacagacatg tattcctcat ggttctcgag gctggaggtc 110100tgcagggctg gttcctttgg aggctgggag aaggaatcgg ccccctgcct ctctccagct 110160tctggtggtg gctggggcca tcggggtact gcttggctct cagacacatt gcctgatctc 110220tgctccatgt tcacatcttc cacattctct tgtgttgtct tggttttctt cccctcttct 110280tatcaggaca ctagtcactt tggatgaagg acccaccata cttcagtatg gtttcatctt 110340aacttgattg cttctgcaaa gaccccccac ttccagataa agtcaccttc acaggtacca 110400ggggttagga cttgaacata gctttttggg cgatgcattt caacccatca cacacgcgca 110460cacacgtgca cgcacacaca cacacccaaa tatatgtaat gaaaactcaa cagtcacaag 110520agcaattatt tagaactttc atcaacaaat gattgtgtgt gtgtgtgtgt gtgtgtgtgt 110580gtgtgtgtgt gtaggactgt ttcatcacta actgtgtttg gaatgactct cttgttggga 110640taaaagcagg ccagttttgc ttggcttact tatcgtgtat gaattatctt ttaacagaaa 110700ttttctgtac cccaggcaag accattccct tcatcccagc

ccaggtagct gctgtcccca 110760aacaccctca gtgggcatga ggtggtcctc ataattcctg gtgatgtcca tttcttcttc 110820catgttttca aacagcggta tggcactttg aggtgaaata tggctctatt taatgtcact 110880ggtttcttga agctctgagt tttctgggac cacaagtttt acttgaaggt aagcaattta 110940aagtatttta atataaacat aactacagta taaagtgtga tgcgtatatt acatatatct 111000ttagaactaa acatgagatg aaaaaatatg aacatggttg cagggccctg aaatttcttt 111060cctctgttac tgtggtaaac aaagcaaagt aaactaagac agtggaaagg gttcatttca 111120aacctgtaag atatgtccta tctctaagtc tgacttgatc atttgtttgc tctgatgcat 111180aaatggcaat ggaaataata ccaccttctt cttatcccag taaacaagtt tgtgagcaaa 111240taatttaata tggggaaaga gcttctgagt tctcagagga tcgccatttt ctcagagcta 111300ggagatgact tagtgcgggg ggtgagccat cttttcggcc agttcgtgaa tgtcttgggc 111360tttgtgtggc agaccttctc cgatcaaaca actctgccgc tgcagcttga aaacaaccac 111420agacaacaca cacacaaatc cagcgtggct gtgttccgac gcaatttgac aaaaacaggc 111480actggccaga cttggcccat ggactgcagt ttgccagcct ctgaacttag aggaaaaaaa 111540ttggaagaat ggagtgaacc ttgagcacag ggaggagcag gcactgaagc tgtctgtgtg 111600ctcttttcct gtcttgatgg agaacaagac atttgtatgc tttcacaaaa caaagacaag 111660tgtaactgtg agttcaaaga ttacatcatt gatttcagta gtgttgatac tttaagcatt 111720tgctatgttt cctctgagct attgggacat tacactgaga tgcagtcggt ggtatgggga 111780ggtgctcagg ggttctcctc tctgccctca ctgcttggtg cttacagaca gctactgaag 111840cagtgccttt catgctgggg agcctgacta tttgcaggtt gttaaatcaa tttaatgggt 111900cgtggtctgc atttgaaaga atagaactgg ctcaacttcc ttgggctaga atggaaaatc 111960acaaggtaca tcctttatag tattttgtga atttttgttg tacacttgaa catatataaa 112020catatatggg atgcatacat aataaagaac tattagggga aaatcaagct gttttttgta 112080aagttaaaac tttggaaaga gtatagtcga gtcacaaact tttctctgtt aagttatacc 112140tagatgtgat gattgtgaaa aattggcaaa caaaaactct agaaaaagtt tgcattcaga 112200ttgtttccca atggcttcct aagttactga aagacatctc aactagaatt taggaataga 112260cactttcagt gttatgtatg ccaaataata ataataataa taagtgccga actctaatcg 112320actgatccat ttctgttgcc caggctggag tgcagtggca tgatcttggc tcactgcaac 112380ctccacctcc tgggttcaag caattctcct gcctcagctt cccaagtggc tgggattaca 112440ggtatgcacc accacacccg gctaattttt gtatttttag tagagatggg gtctcaccat 112500gttggcaagg ctggtcttga actcctgacc tcaggtgatc cacccatctt ggcctcccta 112560agtgctgaga ttacaggcgt gagccaccat gcccggccct gatccatttt taagaaaagc 112620ctttatcctt aaagcaaata ttggtgcatg agtatgtaat gtatgaacac gtgatgttta 112680tgatttccaa cttgcagtca ccttttcttt gaactgttct aatattttgt tcagtcctca 112740tttgtatctg ctgaacctcc ccttgagggg attgtcaggt accctccttt cgcctgtgag 112800ctgagggaaa ggtgagaatg actttagggg aagagaaggg tgaaaagtac caatttccaa 112860ctcttcctcg caatcttgaa atgtttgatt ttgatctcat ctttgcactt tcccctccct 112920gccgtaaaga gagacacaca gttctgtgct gggctaaaag catgtttgaa aagtaaagaa 112980attggaatat aagatatata tcagtccaca ctggactgat gtggccaggc aaggcaactg 113040acctcttcta acgttttcct tcttccagca gagcacgtct ctgtcctctt aagaggccac 113100atgtcaggtg tgtggctctc tctgactctg tcctaatggc agtgccttcg tattttttgt 113160ttgtttgttt ttgttttgag atggagtctc actctgtcac ccaggttgga gtgcagtgtc 113220acgatctcgg ctcactgcaa gctccgtctc ccgggttcat gccattcttc tgcctcagac 113280tcctgagtag ctgggactac agacatgtgc caccacgccc ggctaatttt ttgtattttt 113340agtagagacg gggtttcaca ttttagccag ggatggtctc gatctcccga cctcctggct 113400ggtgatccac ccgcctcagc ctcccaaagt gctgggatta caggcgtgag ccaccatgcc 113460cggccggcag tgcctctgtt tttatggcat gagggcagcc ccggtgaact ggggttcttc 113520gtggaggagt gtgcccgtgc gtgacggaag catgcgcctc ctctgacctg gatgcaggct 113580gggatgccat cggcactggg gctaccacat ggtgctaacg ggctcagaag aagccagcac 113640agggtgattt aaacagtggc cagtgatcca gggtcgccag tgctgaagga aggaaaaatc 113700aatgttgaat aatatacttc acagccctaa agtagactca tatgtaatgt tgagacaact 113760aacaatttgt aaagaggaca gtactaagca gaagagacga cagaaatacc ctgctttggt 113820ttcgtttgat gaattttctt gaggagggat ttctagggca gttcaaaaag aaaacagaaa 113880gcaggtgaca ctcaggtgaa atattcagca tccatctcct ttgtgtctaa gccctggtga 113940gtctgtgtgc aatcagctaa gggccttagc ccatggaccc caggctgcag gcagcccttg 114000ctcactgaga ctggggacca caccagctga tggcctccac tgggttacat gcccacaggc 114060agctgctgag tctcaggata gcgggaagaa aggtcctgcc acaagaagac atcaattaac 114120aaaaaataga taccataatg taaagcaatt acgtggcctg ccttttggaa acttctgggg 114180agaggaggga ggaagtctaa acatgaattg caaatgctgt acatgaaaac agtatgcaga 114240tatatttagc tctatcaatt agttgaagtc acaacatcca gggatgtttt cactaatgca 114300tttcattagt aaatatctat tactattggg tatttattgt taaatatatg catgcgaaaa 114360gacagactaa ggaacactca agtcctcacc tctcagcttt gctgtatctt agcattttgc 114420cacattcgcc tcagatagtt tttaaagaat taaaacatta gatgctatgg aagcccattc 114480tacctcttac tgtgacttct aagatatttt caatgattta agaaaaattt tgaaaagcaa 114540tgaagtcaaa cagttaaaga cactgctgcg tggaggtttt ccctctgatg gtgagatgca 114600gacgctgcac tcagaggaac atgagctggg aaatggggag tctgaagaga agagctgagt 114660tgcaaacaaa tgtccttttt gcttccagcc ttagctttgg ttttatgatg gataagatgt 114720atttgcatat tatgtcctct gtccaatagc atattccaga caggggtttc tgggggcatg 114780attaggaaat aaaatatatt gctgtacagt tgactatggc aagcaaagac tgcagacctc 114840aatcacttaa cttaatataa atgttggagt tatcacagtt ggacaaggat tatggtgatg 114900ttctctacat ttctatgaaa aagtcactat ctggtagtgg ccaccgagct tttattaatt 114960ttgttattgc acaggagaag gaagtcattt cgaggcaagt gtttgcgccc tgatattagt 115020aaaacttcag agggctcagc catcccctcc cactgccata tttttaggag aaacagcagc 115080tgaggcctgg agagaggtga tgtgagattt gtagtgagag atggaaagca tcctggagtt 115140attccaaaaa gtgatcaggt agaacctcta tgcccacgac atagtgtaaa tcctttgtaa 115200aaccaacacc caaagcattt ggggttttgc ggtgctagtt tcaccacgca gtggcttgat 115260tttgaacact gccctttgca gacctagcac catggaaacc caggcctttg cggaggacaa 115320cgcggcctgc gtgctcccat cctggctact gttcaccaag tgtgggtgac cctgggaggc 115380tgcccttgct tgtttacttg tttttcctgg ctgttgattt caaagaaatc tcggtcaaat 115440gagaaacccg ccaacaattt tgaggaaata cagggatgag ctttggcagg aattaggtac 115500gttctcaaag caggccttct gcccgaagtc acagtgaatt tccaacacca caggagctca 115560tctttctttg tccctggtgc agggaaagta aataagagca caattagtgg aaaccataaa 115620gagaatgctt tgaaacttgc atctgagatc aagccaacag gagtttctgg tagaggtgat 115680attggaattt tgaaaagaca gaaatgttca atccaaagga ctttgacttt gtgcttatct 115740cataaaagaa gtcatttgga ggctatttaa atgtgtaaaa ggtacaaagg ctttgtggac 115800caattagttc taggagggtt aaagagcaaa ccctgcccag agccggtgca cctgctggtc 115860cctcttcctg cttcctggaa tgctcttgtc ccagatagct gtgtgctttg ccctgaattt 115920ttctttcggt ttcccgttta aatgtcactt tatctgcaag gccatccctt accactctaa 115980gaagaatttt tctttctgtc cccttgatcc tgccagtttt caataacact agcatctgac 116040attttatttt attaaatgca tattgcattg tttatctcct gtttatccct tccagaatgt 116100aaattctctg tgaccaggca cctgtttttt ttttttgttc ttgctttttg agtcagagtc 116160ttgccctggt tgtccaggct ggagtgtagt ggtgccatca cggctcactg cagactccgc 116220ctcttgggct taagtggtcc tcccacctca gccttccgag tagttgggtt ggcaggtggg 116280caccacaatg cctggttaat ttattattat tatttttttg agacggagtt tcactgtcgt 116340tgcccaggct ggagtgcaat ggtgcagtct tggctcattg cacctcccag gtttaagcga 116400ttttcctgcc tcagcctcct gagtagctgg gattacaggt gcatgccacc atacccggct 116460gatttttgta tttttagtag agacagggtt tcaccacata ggccaggctg gtctctaagt 116520tctgacctca ggtgatcagc ccgcctcggc ttcccaaagt gctgggatta caggcgtgag 116580ccactgtgcc cagctccaat ttctaaattt tttgttgggt ctcactgtgc tgctcaggtt 116640gatcttgaac tcctgggctt aagtgatcct tccacctgag ccccacaaaa tgctgaaatt 116700acaggtgtga gttactatgt ccagcatcct tggtatgtgc ttaataacca ggactgaacc 116760aatgtttgga gtagaattag tttgctttaa ttattcactg aatgaatgat tacataaatg 116820actaaataga agttttaaat gctaaatttc tagactccag agtttagagt gaattagtgt 116880ttgttttttg tttgtgttgt atttaagcaa cttatttata cctcttcaaa agggtatctt 116940tggtgtctta taaaatgtac atagaataat ataaaaatag atcctgaaat cagagcaaag 117000agaaaaataa gagtggcttc attcttgtag cagaaaatct gtattctaaa aatacatttc 117060taatatagtc taagacagag catgggaagt gaaaaacatc acaggacgat ggttctccaa 117120cttgattcct gtggaaaacg tgtactctgg aggctgaacc tggggtttta ctattaaagt 117180gagataatga tcgtttccag gtgcacatac aaggttgaga aaagggatag gcttttttca 117240atttaaaaag ttccccaata actttttctt aaatctttgg aaattctact gcttctctgc 117300tggaaagcac ttaaattgat aagaaaaaca gtgaacaagt accaaactct caaccgagta 117360ccttggaaat agctacctga gttagcctga cagctggatt ttcatggaca gctgtgctca 117420tagttgtgaa tttgtattgc gtgattttaa tgttgccata cttttaatcg ctaaaataac 117480cctagttcaa aaaacagagg taaacattga tattttatca tgtttcgtaa ctttctgatg 117540tttcattccc taagtaattt taagaaccct tgtttagaca tctggcttta tgggacaatc 117600aaaaatatga tttgagttct ttatttcagg acaatttatg cacataaatg tgctacagaa 117660aataaggagg agtaggtttt acttaagccg actttgtttt ctcctgtggg atgaagagca 117720gctctttcca ttgatctgat tgtcccaaat aatgtttcag tgcttcagtt cattttgacc 117780acgtggtcac accccaaaat gtcagccaca acattacact gtacacacaa aagtccagat 117840ttaccgctgt acctttggtc caacaacatt tatatttagc ctccaataaa ggctcaactt 117900gctccaagag atttttaatg aagagcacca taacattccg gttgcaatta tgcagtgaat 117960ggcaaattcc agaagcataa gtaaatcaat ggagaaagca caatgatccc ttctacacta 118020gcatctggat ttttaaaaat ccacatagcc tcttccttcc tttctccctc cctcccactc 118080ctccttccac cctctcccct gctgggcatg tgaggcttgc tccaagcttg attctgagtg 118140gagttttcgc atttctaacc tgcacagagg ccgggtccag ccttaggtgg ctgtcccatg 118200gtggacttgg ggctgccata cccagttcat tttctcaacc cttcacttca ttttcgcccg 118260ttgacacagg cttagtgggc tccggatttt atttttttta attccaaacg gttgcctaac 118320tttccccttt cgcctaaaca cgatagagct gtctttcttc gctggagctg cttgcacggg 118380cacggtggca tttgctgcta tttcagctct ttccacgcag caaatctgct ttccccagcc 118440ccgaagtaaa catcaccttt tccctagttg acctgcctct gctgaaaaca cacccacccc 118500ttcctgctcc aattacaaac ttagacttga ctgtgggcca agttgctttt cccacaggag 118560caatgtctct gcctcacact tggtttttcc aagggaggcg gtgactgagg ccagcacaga 118620caatgctcca gcctttgtat ttgctgggcc acagagagcc acgtaacatt tattcagatc 118680cagtgaaacc taatgcgagg aagccaaggg gaaggtggtt tctcctgcgt gccattttca 118740aaagtgtgcg agctgtctgt ccaactacac atctcttttt aatcatgtct gctgaggtct 118800gacctagatg tgtcccatcc ctcacttcct cttggggtgc ctaagagggt taccatttgg 118860ggcgatgaca ggtgtgtcct ggaatgggcc ctgttacaca ggtggattga cctgatcctg 118920ggtgtgtgag caaagcccag tgctagcaga ttagttatgt cataaaacat taggaaatat 118980tttatacagt ggagataagt cggagaactg caggctgctg ggttaggcca aatcgttctg 119040gaagcagggt caaatgatct tatatactgt gtttgcctga cttggtggag ttgaaactaa 119100tgactcttct tcgctttgtg gagcaaaact tccaaactgc attatatttt tggctctgac 119160cttgcacctg ccaccccaca gccccaggca tcattagaca ccagcacaag tcattttctg 119220aagacgtgaa ctcctgttgt ggtttatttg ctttcatgac ccaaagacct gtcaggcttt 119280gagtttttct tggtagcgag tgttccctct ctgcacctca gcttgtagag ctcttccatg 119340ggaagtcaca gagtttatac ccagggatgt ggctgcattg atgctgctgg caggggctgg 119400ggggaggggt gtcctgtttc agcttctaga aagctgcctt tcccattgcc tacaacggtc 119460attgcatact ttcaccattt tcattttccc ccaactccta ccttatccct tccccaccct 119520ccacactgaa cacccaactg tgattttgac tttttaaagg aaacagatac atcaggacaa 119580accccctcaa ctttcaggtt acttttctac caactcattt ctacctgttc acatacctgt 119640tttaagctca tatcagagaa gttattcctt ttgcttttca agaaggcact caatactgct 119700ttttttccta tcaatgtatc aacgaatctg tcatcttccc tctgttttct acccttttgc 119760cactgtctta aaaagtcaag aaaaaacctt ctctaaacct tcaatgttaa atttctcctt 119820aatccttcat ctcctccttc tcctcctctc tgtatttctg tttatcactc attttctaca 119880ctcaaaactt tattaccgtc atcacgatgg tacttgccat tttatattca tctaacacat 119940ttattgagca ttttttttta aatgtcaaaa atggggttgg atcttggggg atagaaaaga 120000aaaagctaca gttgtgaagc atccatcatt ctcagcaatt atcttgttta tttatacaat 120060tgcctatttg cgagcatcga agtcacagag cctgtgcttt cactgctgta tgttgggagt 120120gctggctgtg ggataggggc tcataaaaag cttttgaagg aatgaccgaa gccatcacca 120180ggagtttacc gtagaggaga catgagcacc tgatcacagc tcaactgtgc ttgtgatggg 120240gtgtggggaa tgtcttcaga actgcagtgg agaaagcact ctgactttgc ctacgggtgg 120300tgggaggttt tcctggagct acatctgaaa ggatgaaaag gagtaagtcc agtgaaggag 120360gaccgaggga atgggaacat tctaggcaga gaaagggagc agaaagctca tgagtgaggg 120420gctgagaaca aacttgatgc attcagggac tatttagctg aaccaagctc ggggaggaca 120480agatggccag gtgtggactg gagggaggga ggtaaaaaag gtgagcatgg gctttgtacc 120540tcgtgagtat gggagcatgg ggaaaggagg cacgtgttgg cattggtgga gcccctcatg 120600agtatgggag catgaggaaa ggagactcag gttggtattt gtgaagacac tcttgatttc 120660agtgcagaac tcattaaaat agtgcaagat taaagcaggg tgacctttct aggaagccaa 120720gggagggcta atgatggtgg gagcactgtg atggtgggag cattgacagt gatggtgcaa 120780ttggagggaa gatgacaggt tcaagcaacg ttgggctaaa aacagactga ccttggagag 120840atgaagggct cactctgtgg ggaaggcgag acgtggagga cacacgcctc tgctgtattt 120900tggaatgagt tttactgtca aaacaattga acctatgtta tttatcactg ttttttcttt 120960tctttttttc tttcacaaaa ccagttgctg tgctctagtg ggtcaggtga gccagctcct 121020aggtaaggag agttgtgtgg ggctcctccc tcaagccgcc tgcgcacttc attccagcct 121080ctgcacaagg ctgtggattg tgtttcccgg tccaggtctg ctgtcctttc ctgtcaccag 121140catctcccag agtctggcag ggggtttgtg gatcgacagg tccacctgtc tgtgcttgtg 121200tttttatcct tttctgtgct ttcctactta ctctaggaag gaattggaag tgtttgagcc 121260aggcactgtc agatactgtt ttagttctga agtaccctct gcttgaaata acgttggggg 121320gagcttgtaa cttgtagaag aaaaggagga ggcactaaag tgaaccgctt ggtgttcaga 121380acttcgcagg ctctgtgctt atgtgtatgt gtgtgtacac accagcactg gctatgtgca 121440aagaatgcag tgtttgggga aaagcataga atttggaatc ataaacctga ggtttgtcag 121500ctatgtaatc gcagtgtttg gccactctaa acttcatttc catcagctgg aaaataagat 121560gaataaatca tcagtcccgg acatctatga ggaagacatg aaataactat tgcatggtaa 121620gtgtttagtt cagtgggtga tgacaatgat tatgacatac gattatggaa aaagcccctt 121680tccttccaaa atccccaaaa tgaacaaata catacgttgt tatggtataa atctggtttt 121740catgttatac aaggagttat tagaacaatt tggaaattct ttccaaatta aagctctttc 121800tgtatgttga tctaatttta aaaattttct gtttttatgt ataaaaagca atcagggcca 121860ggtacggtgg ctcacacctg taatctcagc actttgggag gccgaggtgg gtggatcacc 121920tgaggtcagt agttcaagac cagcctggct aacgtggtga aacgctgtct ctactaaaaa 121980tataaaatta gctgggggtg gtggtgcatg cttatgatcc cagctactag ggaggctgag 122040ccaggagaat tgcttgaacc cgggaggcgg aggttgcagt gaatcaaggc tgtgccattg 122100cactccagcc ccggtgacaa gagtcaaaac tctgtctccc gcctcccccc caaaaaaaac 122160gcaatcagcc atgattataa aaaaggaaaa atgtgttact gaaatttact taaaatgttg 122220acaaaaagat gacaaaataa tactctggaa tacaagccta gtataaatgt ttttatttgt 122280tgcatttaca atttaaagca gaaacttgtt taagtttttg catcgcacat agccaaaagg 122340aggatgtggg cgaagtggcc aatgtcattg tttaggccct gtgcctggaa tgtggcgctc 122400ccactggtcc tgctcacagc tctgccatgc cccctgacct tggtgtgctg tttcacaaga 122460gcatgccctg gtgcaggatg agggacaggt ggctggagag gatgggcagt caacacagtc 122520catccttgtg tttggaaaca catgttcact tgtgtgcaat gttgggattc gtggagaagc 122580tggctggaaa gttggtaaag tatccagaag acaaggtttt gccccagcta ctcatcatct 122640gaacagccag gtagattcta ctttgcagac tgagcctaag ccttgaactc tatcgggaaa 122700taaacagaga tggtgaactg cgatggaacc caagtgcagt tagttacagc aaacacatct 122760catgtgaata cataactccg ttgtgaatac ataactctgt tttccaccct taatacccat 122820cacatctaac cccaatacat ccaggaagta tgtagggtct ccacgacaca gaccatcatt 122880gatgtccttg tctgatgagg gcaggggaag agctgataaa acacctggag acaattctgc 122940ttggagaagg tagcttggag acccttgcct tgcttctgag catgacaacc agcaccactg 123000ctctgggccc taatggcaca tgcccccatt gctgaacctt ggctctatgg ttcataggtt 123060acaattagca ctattgtgta attctgtgtt ttctagttaa ctgcacaccg tcttggctct 123120tcaccatgta cgatattcct tatttagtcc ctggaccttc tcatctggac ccgttattac 123180ctcttcccct ttcgtgtccc atctctgctt cctaagccaa tcaaagctcc ccatatgggc 123240tgaggcttca gcttctccac aaggttccct cccagaaagt accttatctc cataaactga 123300agtgctattc catcctcaaa tccagtccca gatgccctcc actcaggagt cagctctttt 123360tttttttttt ttttttttgg tagaatttgc ctatatctct cttatggtat tgatcatttt 123420atagctggtg gggttggtat ttgtggatgt gttttggcat tccttctgga ctgtaaactg 123480ccaagaacat gaccatgtct tggtttttta aaatactttt caacatttat cacactgttt 123540ttcccattat aggtgcttag gaactttatt gtagggatgg caaggtcgac tcctttgttc 123600ttgcctcagt ctgagtgttt atgccataaa aacaatgtct gtgcaacaat ggcaacaaca 123660acaagaagtt acacacagtt ttatttcctt ttttagtctc tacctaaaaa gtttgcactg 123720aaaattggac catagaatgc ctaaaattca ttcattcaac aaatacatat tgattatgca 123780cctactatgt tccaggtaca ttaacgtatg cctcccccgc cccttcaaaa aaaatccctg 123840ccttattaaa cttatattct ggaagaagaa gacagataat aaactataga cataataagt 123900acataatgca gtatggtaga atatcataaa tattgtacac acaggaaaac aaagatatgg 123960gtgatgcgct aagggcaatc ttaagcaggg tggtcaggct gaacctgatt gagacaatgt 124020gacaattcag atacagagag aggtgagcaa agtttgcatt taatatgata attgttcaga 124080ggcataaatg gaaaagaatt tctatttgga atgtaatttg taaataaggc ttgtgggttt 124140tcaacattag ctactttttt ctttagcctt tataagtctg ctagaaataa tgaaatcaat 124200tgaataatga ggtagagttt ttattataaa ggggagattt atgaacccac aataaatggc 124260tttgaatctt agttttcaat caaggaccag agtacctaat atttaatctg tctgtctgtc 124320tatctatcta tctatctatc atctatctat ctatctgagt ggattctctt tagtcttctt 124380tctcatctct aatctacctg gatgttgttt tgctatttta gtttcctaga atagcatttc 124440ctctttgact tttcctttta actctgcttt ttgtctttgt ggtgactaat tgatgtgtta 124500aaaaaataat atttataata tttgtattgc atttcatcac agctctgtag ttaaaaagta 124560taaaaattgt tttcaaaata aataggttta ataatacata aagccaaggc tcgagatgac 124620tatttttcat tacaaaaata gtcatttaga taattgactt ttcatttaga taattatttt 124680catttagata attgtagatt cacctgcagt tgcaagaaat aatacagaga gacttgaggt 124740acccacttgc ccccatggtg atattttgca aaaacatggt ggaactatta cagccaggat 124800atgggcgttg acacagtcca ctgattttat tcagatttcc tcagtagtgc cagtagtgtg 124860tgtgtgtgtg tgtgtgtgta tgcatgtgta tttgcgagtg tgtgcctgca tgtgtataca 124920tgtgtgcaca tgcatgtgtg tacacgtgcc tgtgtgcaca cgtgtgtgca tgtgtatgtg 124980tgtgtctctg tgtgtgttaa gttctatcca cttctctcct gtgtaagttt ttatattcac 125040taccagagtc aagacactga acaattccat agcctcttcc ctctcacccc acttccccca 125100tccctaactt ctgggtaccg taatctgtct tccatttcta aaactttgtc atttcagaaa 125160cgttacaaaa aaagaatcat atgtcatctt tgagaattag atttttccac tcagcataat 125220tttctgaaga ttcattcaac gtgttgtatt agtacttggt tcctttgcgt ttctgaacgg 125280cagtcctcag tagggaggta ccatggttta tttcaccaat cagctgttaa ggatgcctgg 125340gctgattcca ccattgggcc attgggtgat gatgaataaa gctgctccgt acattcctat 125400acagctttcc atgtgataca taacatttgc tttcataatt actcttgatt aagattcaga 125460atttgaatgt tgaccttgaa ttttaacata atttctctgt ccttatgtaa aattggcttt 125520agtaaaattg gttgccaatt tgtgttcaga tgtatatgga taaggaaact ttccaaagca 125580aatatataaa atgtttgaca gaagtacaga agtattaatt acattttaaa tttttataga 125640gaacctcaat gaatgaaatt ggggatttta tagcattagg taggaaatta tataacaatg 125700gaatttgttt ttaaatagaa acattgtcat aactgttctt aaattaaggg gttgaattgt 125760gtcccccaaa atgctgaagt cctaactctc catgctcact

caccagtgtg acctcgctta 125820gaagttgagt ctttgcagat ggttaaggtg aggccattag agtgcctcta gtagaatatt 125880actgatgttt ttatagaacg ggaaaatttg gacacagaga cacctgtaga agaagatgat 125940gtgaagacac acagagagag gacagccacc tacaagccaa gggaggccaa ggccagaaga 126000cactgggaga gcacggggaa cagattttcc cttggaagga tccggtgact tttttttttt 126060ttttttgaga caaggtcttg ctctgtcacc caagctggag tgcagtggtg caatcatgtc 126120tcgctgcagc ctccggctcc caggctcaag ggatccttcc acctcagcct cctgagtagt 126180ggggaccaca agtgttcccc aacattcctg gctaattttt gtattttttg tagagacacg 126240gtctctctat gttgcccagg ttggtcttga actcctaagc tcaagccatc tgtttgcctt 126300ggcctcccaa agtgctggag ttacaggtgt gagccatgct gtctggcaga tccaacacct 126360gaatctcaga cttctagcct ctagaactgt gagacaatac atttctgtca tttaagcctc 126420tagtttgtgg tactttatta tagaagggtc aggaaacaaa tatgatatat tattctgcat 126480gtatagaaac tttaaatttc tgactagtct atcaaagcaa cactttttac tttatctgtt 126540ctcaagactt aaaaaataac cttgcatgta tggaatttgg attggagttt ctccttccca 126600tctctttagg aatctttctc agtagcaccc ctgctgtgtt tctctgttgt tttacctata 126660tatttagaca gatcccaaat tatgaggaaa agacaaaaca ataaaaaagc aaaaagaaaa 126720caaaagacta acttttgatt tttgccatcc cccaatttac agccaatccc ttatcccttc 126780ctgcccattg atggttggaa tttttttttt ttttttttga gattgagcct tgttctgttg 126840ccagggctgg agtacagtgg cgcgatctcg gctcacttca acctctgcct tctgggctca 126900agcgattctc ctgcctcagc ctcctgagta gctgggatta cagccatgtg ccaccacacc 126960cagctaattt tctgtgtgtg tttttagtag aaacggggtt tcgccatgtt ggccagtctg 127020gtcttgaact cctgacttca aatgatctgc ccgcctcagc ctcccaaagt gttgggatta 127080caggcgtgag ccaccatgcc tagcttttgg atttcttaat aaataatctg tcccaacatg 127140aggcagagga agctgaggtc taccagatgt ccgttttcct tcctaggtgc agaattctca 127200gtgcttagct gagtgcgtca tcatctggga taaaggctgc atctcctagt cttgcttaca 127260cttatttgtg gtcttctgat taaatcatgg ccagtgagat gggtgtggga gtaagcgtgc 127320ccgtaaaaag ctatgagaac taggtactgt aatttgggaa ccatagatct atccactgta 127380gtttgggaac cataggccta tcctctgcag tttgggaagc ttggatttat ctactttctt 127440atcatctact caccccatct ccttgaatga ctgacgttgc ttgctgagtg tcactaggaa 127500ccacattact gcccagtctg atggctttct taatctatta gcctctgcag tttctgcaga 127560gtctgaccca gtggaaactc tccatttccg gaaagctcca tcctgaggct cttttgcttc 127620atctctcttg cttccactgg ttctttttct ccttcccaac ccctaaatgt tgttctctca 127680ggcttttccc ttaaccctct tttctcatct agtctttcct caatctaagc caattgcatc 127740cattctaaga tgtcaacttt cattctaggc aaacgacttc cacatcccca gtttaatccc 127800tctgactgct gaaccctagt ccatgttttc aactgcacgg tatccatctc cacctgaacc 127860cccacccttg cctttgacat aaactattca aagcatttga actcaacctt gctttcaaat 127920gagctcccct tttacctgtt tcttgcagaa gccttgagcc cttgctgccc aattctcggc 127980ctgagagtta ccccagtgcc tccccccaac cctcccattc ccttctctct gtttcaccct 128040cattccaacc ccatctgcct ttgggttccc ttgattcaca gatgggttgt acctctaact 128100cctggctatt cttttctacc tccagttttt tgtttctcca atccatccct gccagatcag 128160attttctgaa atgcagttct aatctgattc tccctagcaa aaccttactt caagcccagc 128220cttttcaccc tattgtgtga gcttctctct tcagttctgg caggatctat aatgtgcacc 128280accaacggga ggtgtgcggc ctgagtcttc tcggctcagc acgtttgctt gtttgtcctt 128340cctccagccc aaaattacca caaaagttgt tttttatcca acaaacacct tcagagccac 128400ttattatatg ccaggcactc ttctaagcaa tttgtaaata tgaatttttt ttaatcctca 128460taacagccta ataccagaag ttctattgtt attcccattt tacagagaac actgaggtaa 128520agagaagttg aataacttgg cccaggtccc cagtgttctg taagtggcag agctggggtt 128580ggagcacgaa cccatactgt taccagtgaa agcagtgtac caaaatttta agtagagatc 128640actgttctgt aactcattaa gtttttttaa aaaaatagta attatccctt aaaaccatta 128700caaaaacaga gaatgaagaa ttaaaaaaaa atagatttgt tgtaaatccc cagaaagaaa 128760attaagcagg tctccatcaa agactcataa tagaggaact caaaattttg gtcttctaaa 128820agaagacatg gactttggtt actattattg tttaggtttt tctccagtgg tgatgaagta 128880aaaggagact ttgacctttt catagacctt ataagttggg ctctggcatt tactgtttaa 128940tgctctaaag gttcaatata caaaatgtag aataaaaaaa tcatcttgcc ctgggttgcc 129000atctctgaca gctgtgcttt gattattgtg gcagtgctaa gaggttcatg tggaggtggg 129060agtgctagga caagacagcc tgagttaaat ttcaatcctc acacttacca gatctgtgta 129120caggtgtcat cacctgtcaa atagaggtga taccagtggc taccttactg aggaatggga 129180gagttccact gaggtaatat gagtaaaaca gctcttaaca ggcataagca cttaaaaacg 129240gtaattatca tcatggcgtg atgtatttgc ccatgttcac actgcttgaa agatactacc 129300tgagactggg taatttataa agaaagaagg cttaattgac tcacagttct gcatgactgg 129360ggaggcctca ggaaacttac aatcacggtg gaagatgaag aggaagcaag gcaagtctta 129420catggcggca ggagagagag agcgtgcagg gaaaactgcc acttttaaac catgagaact 129480cactatcatg agaacagcat gtgggaaacc tcctctgtga tccaatcacc tcccaccagg 129540tatgtccccc ccttgacaca gggggattac aattagagat gagatttagg tggggacaca 129600gagccaaacc acatcacatg ctattcaata ataatagaat tgctctgcaa aataaaaaaa 129660atgaagctaa caaattttgc ttataacttt gcaggagtat tggaagtttt tattcctact 129720gccaacaaag actatttatc tggtatactc atagtgcctt taaaaaatta cacagcactg 129780ccctgtttat ttttagtttt gtaatagaat tcatggattg gttgttcata gtctttacta 129840tggcatcatg agccttaagg aaagaacaag gagatttctg agagtcccag cgggttatac 129900tgtgaatttt actcatgtta ttcttacact gggaacagca aggaacttga cttgactttt 129960accctggcag acaatcttga aacagttttt caaataaaag atgttatttt taacaggaaa 130020caactgatac taaagatctg actcagactt tactctcctt caaatgatgt ttgaagttca 130080gcttgtctgc agctgttcat tatgtgccta ctatgtgcag gcctggaggt aaacaagact 130140cagccttcat tatcaggggc tcatactcca gtggagaagc cagattcatc aacagatgat 130200ttccaagaag tgtggggagc acacatggtc ccagaaactg ggaatccagg agatactcat 130260tgcactgtcc tttaggctga aattcaagtt ggagcttcct ccttgagtcc cttgtcagtt 130320tctgcttcta tgtagctgac tgtccatctg agaggacgca tcccctatct gaggtcatca 130380aaagacctgt ggcagccagg attcaagccc aagtgtcctg tctcctagct ctatgcttgg 130440gcacaccaag catagagctt gggtagagat gttgggacaa aaaccaagtc aaataaacaa 130500aaaacccagt tcttacattt aaggatccgt agagcctaca acatagtttt gtgtctcaaa 130560tttaagccac aaagttctgt taaccgtcat tcatctagca tatagttgtt aaatttctcg 130620tatgtggcag gcattttttt ccaggtccta gaatttagaa gagggaacga tgaattaatc 130680agagattgct gagatagaga caaaccaacc aaccaaccaa acaaccagcc agccagcaag 130740caattagccc tcgctgtgca catccttcag tgattatggt cagcagaatg tggaaggaat 130800tcatttgttt atttcttttg agggatgaga gagttgagga ttagcctctc caggaattgg 130860catcaagaat caacagggca aagctgaagg ataagccaca attaggcagg atgcagaggt 130920gagactgaag ggagagaggt cagaacccag agaggaatgt atgcatggat cattaaggac 130980tggaactggc aaacatcttt gtagataata atgggaaact aggtataaac aagggaaaac 131040taggaaacta tacaggttct aatagagagt ccgttgtcgc cctgggaagt gtgctttttt 131100tctttgactt aaccaccgta gagcggctca caaggagcac agatccactg aaatgcctga 131160cgattgggag agacgaaatc tctgttgtct gtttatattc ttattttatt aggtctgttt 131220catgtcttca agatccacga gtgtaggaca cgatgccatt tcccctgtat gtcttcggtt 131280tctaagcaat taagaaatat aatttctttc tcaacattta ctgatgtgga aatttgggga 131340tctgagccag ggggcttgcc atcatccggt cattggaaaa gtgcataagg gaacacaaag 131400ctagagtacc taggttggga aatctgcttg cctgcaaatc cagctcaagt tggccaggaa 131460accctgccct atagatggca aaatgtaaat cccctgagac tagttaaaga caaacacatt 131520tcattgagtt ggggttttgt tacaaaatag gtaaacgtgc atggtttcca ggccaacgtt 131580attcagacta ctaaggtctt gaccaagttg gcagttcttt ctagaggcct tagttccact 131640ggaattagca ggttcattaa aactaaaact caaagaggga catgtcagct agccaggaaa 131700ctgagttgac taggtcctct tgaaggtttc attgtaacat tgggtaccca tccaagtcct 131760agtggccttt gtctcagatt gctgcataaa agtggctcaa catgaaggcc aatgtgaaga 131820catattggat aagggaattc atttctgttt ctttctgcca ccgcccctca tttattttat 131880caccataaag atgtaattca catatcatga taccaacttt taaaaggagt gtagttcagt 131940agttgttcgt gtattcacag agttggcaac catcttcacc atctaatttc agaatgttct 132000atcatcccaa agagaagccc catagccatg acaccccatt tctcttgact cctagtccct 132060tacaactact agtccacttc ctgtcatgat tgacttgggt actctggata tttcatataa 132120atggaatcat acgttatatg ttgtgtctgg cttctttcac ttaacgtaat gtttaaaggt 132180tcatgcacgt tgtagtgtgt gctagcactt catttctttt ttatgactaa ataatattcc 132240attaaagaga tatataccac attttgtttc ctcattttct aacttttcag taagaattta 132300aaaaaacaca ccaatacaat atgctgtctt ttaacatgct agccctaaca tggtaatgcc 132360tggaatattg tccacgaatt tctctggtgt ttctttggtg acttgtttac ttcctcagtg 132420atgttgcact gttgtgttct gaccctgtct gagtcctgtc tgttctctgg cttgagagtg 132480gctttgactg agctttggga taggactgct gttggtctgc agttatcacg ttcagacttt 132540atctgagatg cggactttgg gccagataaa tgcaggattt tctgaactca ctggtgagga 132600aaagcatttg ctaccgctgg ttcttcgaca gcatataact ttccctaagt caggagtgcg 132660tgtgtgtggt tgctgggtgt gggtgaagat aatcaatttt atgcttctga taacctttca 132720agatttgcag caaaagaact tggtggccct gaagactctt tttcctcttc ccattcctgg 132780gtctaacagt tacagtcatg gctgttctga agctgagcac ttggtggtgt ccatgacttt 132840aataacatgt gctgggagcg gtggctcacg cctgtaatct cagcactttg ggaggccgag 132900gtaggcggat cacttgaggc caggagttcg agaccagtct ggccaacatg gtgaaacccc 132960gtctctacta aaaatacaaa aattagccgg gcttggtggt gggcacctgt agtcccacct 133020actaggaggc tgagggaggt gaatcgcttg aacccaggag gcggatgttg cagtgagcaa 133080gatcttggca ttgcactcca gcctgggtga cagagcgaga ctccgtcaaa aaaaaaacaa 133140caaaaacaaa caaacaaaaa acaaaaaaaa ccctaaacag tgctggggac aggcaccaca 133200acttaacagg gcatctgccc tgtgaagcca cagaggtagg tggtgggtgt cttgaggtgg 133260ggggagaaag gcaagattgc tgctgggcaa agtggagaca gtgaggttca agccaccatg 133320cgtcccagca ggtgtggagg tcacaccact cagcaggtgg aggatgcacc gtcacccact 133380gtgaggcagg gaccttcctg tgggttcaca gaggagccct ccagcaatgg agtaacactg 133440cagctggctg ctctgctcag ggtcgcagcc cagggtagag tggaagacag aggagcaggc 133500tggtgaggac aggctgctga aggcttccac tttagtcttc acatctaact cggggcggct 133560tcatagcagg gagatagtca gcaagaactt ccaaatcatt ttcaaagtct atcaggaaca 133620tttctggctc agaatctcac gctccctcct ttccagagct acgttccttt gtattttcta 133680tagaagcaga cgtaggatct aagcatatgt ctctgagggt gcctggacta agaaatccag 133740gagattcagt gaagaattgt gttatgtttt tttttttttt tttttttttt tttttttttt 133800tttttttttg tcgtatgctt ggcagagagc aggtaattgg gcccatcatt atttagggct 133860aaaaatttgt tgatttgaga ttttttggga ttggctaaaa cctacttcag aacaacatgg 133920gaaggaaaag aaaagctatc tttgtttcag gaatgccggg cttcagcttc cctggtgagt 133980aaatgaagaa actgcctgcg actgcttggc ctcagactgc cttgcgaagg ctccttctgg 134040cacaatttgg gctttgaact tctcccttaa tttctgaatc tgtgttgtga taattggctt 134100tggaaaggtt acgagaggtt gactctggcc tgacacggag gctctagcca atgccagaga 134160ggtaggcttg gtgccagagc tcacctcaga cccacatctc cagggagtga caggaacaga 134220aaatcagcca agctactgtg acccagtcgt tcagcaaatg tcggagcgtt gcaatgcctg 134280cccccaccct accccagagc aaggctgggc acctgaacac tgtgtggggt actctgcgtc 134340tgtgctctgg ggaagggggc tgtgaaattc acctggagat ctgttttaag acctgcgctt 134400tcgaaatgct ctcaaactct tttatcaaga cagtacagct tggacaaatg tccacaatag 134460agaagcagtg acatcccttg gacctccggg aacagcagcc ctgtctgtct ctgaacgggc 134520cttcctccct caggctcctc tcacccctcg gggctgccct caggggagga tggcctcacc 134580cagtgaaggt taactgggcc ctttgtttgc aaatggcagg acaggagctg gtgctagctg 134640atcatgaggc tttttacagc atcaaagtgc tgcagtttac taagaaatca ggaaagcata 134700ttccaaaaca gggttgtctt ctaggaagga acagagagga ctctgccttt ctactttcag 134760gcatccagcc ctgtatgctc caccagggta tctgtgagga gaggcagcgt gagcaggccc 134820agtggaagca gggatggaga aggaggggtc tcccataact cactgcagat gctgagtata 134880attaaaatgt gaattacatg tgtctaacat ggtaaagagg ctcaggtaac tgagcgaggt 134940tttctccttg aaggtagaaa tgtctgtgta aggaggtcat tccacctttt gggctacctt 135000taaatgagtg tttttgaagt ggtattcttt aaaaaaaatt tttttaaatg caatctgtcc 135060ttgttctctt taaagcaaat atctacagag atgtttatca cattatcata cctctggttg 135120gaaacaatat ttttgacttg atggatttta tattttcact attagaagct actcctttat 135180tcccaagtat aaaattctag cttcaaagta aatgcttggc caatcaacac caaataaggc 135240aggaaaaaaa aaaaaaaaac gcagaaaact cacaaagcct cagattataa ggggcctagt 135300caggtttcag aaactctagt ccaaacaggc attcctaacc tagcccaggc agctcttacc 135360tcaggcactt agcaacgcgc aggccttttg aatttgctta aaactattaa gaagtaatta 135420agtagttaga gggtcttttt cagccctgag gtccaggagg tgggctaaat gaaagaaaac 135480aagcgcaatc gctcagcctt gtcttccttc tagctgacct tgcacgctaa taaattcatc 135540ctgtattttt ctgctactgc caatttatgg cctacaggaa actaatcttg tacaataact 135600accttcctgt acttagttcc taaatagagc caaatggatt tggtggcgga agagctcccc 135660agcacttcct gtgaggcagt tgctgagccc agcaagatct gatagaggct tgatgcgctt 135720atcgactctg acgatataat tatgttcttg ttttggctgc cctgcactta agcacagaaa 135780ataaaaaagc aatcctctgt acaacgccta ccacaatgat ttaaacttca aactggaggg 135840taagatgtgt atttgaaaca agccacgtag gcacagttat ggtgaattta gggagtgaaa 135900cacacaggtg atcaatattt cactggagtc tttgatataa aatatatatc tgctctgtga 135960tttcaaaata ttcacaaagg agtaaatttt ttaatgagct aatgaaagaa ctgtgttttc 136020atttcaaacg ggaagagagg gagaaagaga gagagaatag aaatatagag ccatttcttc 136080agtaatagtt tacaaccagt ttgccacagg cttggattaa agtaaggaaa ggctgtcaaa 136140acgcagggta acctgtgtga tatcttttca gaccctcaaa tagctcaaat actacgctgg 136200gaaaactcag agtttgtcct ttaaagaacc tgaaagtgtt taatctttga taagtgcagg 136260ctcctcaggc tttgccgctt ccccacaccg gatttgcctg ccactcaccc ataccgatct 136320gatgacttca tgtggacacg gatcggtccc gtatgacagc gtcttcttcc tgtgctcatt 136380tattctagaa ctatagcaaa gctgctaatg caaagggaag ccttctacaa aaaggatgaa 136440gaaatcaccc tgaccaagag accgaagcaa agatgaaagg aaggcataaa taatcgcagc 136500tcgggtccga tgagacttat tgctggggct ttcagaccta gagaggtagc aggggcgggg 136560tgggggtgcc tgtacgcggg ggcggggtgt cccacccagt tgacctggat tagagcccat 136620ggggctgcat tccgggcttc cgtgtttccc aaagttatgt ggtggcgggg ggcctggctg 136680ttaaggatct ggggatgtgg ttacctatgg cctctgaggg tgacaccagc tgtccagcac 136740tgtgaaatca aacaatggta gtgggccaga aagatggctt agcttcctcc tgagtatgag 136800caagtttccg taactgtgaa tcatccttcc ccaaccataa aagtgggcat attaatacct 136860gtcttgtaag aatcctgtga agatcaggga taacaaatgc aacttaataa aagtaacctg 136920ttatgtgttg gctggtgatg ccataaatgt attttgtaaa atctttataa tggtgactaa 136980ccaatatatt attattaata gcaataggag tattgtctga ttcaaagggc gcatttagat 137040tgtggtaatt ctgtgtgtgg ctggatggga gactggaggg ggctggaggt tttaggatga 137100gtgggacagg gattattaga agtggctaat aaagagatca aagaagtaac tttgttccta 137160atttttaaaa tcatcattct acctcactct cctaaaagtg atgaggatca taatatttat 137220gccttacgtt tatacaggac tttatacttg aatatccctt ttacatctct ggtccgtttt 137280agaaatttga gcctaaacat gggaagcaga aaaaaagtca atgtggaaaa gcactgtgcc 137340catcccagtt tggccagaat gatttcagat tgttatcaag aaagggaata gcggcagcat 137400ggtttggttt tcctctctca agaggactgg acacagggaa ggaacaggaa aaaacctcct 137460gagcaaagca aggttccaga acagactagt tcaaagccta cacatggtta gtgctccgtg 137520gaggtgccag ctcacggttg gtgcaccgtg gaggtgccag ctcatgctta gtgcaccgtg 137580gaggtgccag ctcacggtta gtgcaccgtg gaggtgccag ctcacgctta gtgcaccgtg 137640gaggtgccag ctcacgctta gtgcaccgtg gaggtgctga ctcatggttc gcgcacagca 137700gaggctctgc gttttgggat tcgtctgttc taattgtagc ctttcactta ctgccctaag 137760actggcatgg aaactatgtc tttgagtgat gaaagggcat ccggtgtgtg gaagctcctt 137820gcagagtttc tccatattgt ctccttgata gaatgtagct tactgctggc ttgctttgca 137880catggcagtc actcggtgca tgctggtgga ataattgaat ggaagctcca gggccatcac 137940ctgcacacag tcccccggag gccctttctt ctctcatatc tcagcttccc actgctcagc 138000ttgatgtcag ggagacatcc ttggtctcca ggaggtgaga gggaacagaa cactaacacc 138060ccagtgaaac acagattgac ttattgttta gcagcaacca ggcaggcatg ggctccctcc 138120ccgctgccag catccacacg cacctcctcc gtagccatgg taatatttcc cacatgccac 138180aagtccgtga catggtccta atgaatagaa tgctttatgt ttagccccaa acgtggtcat 138240tatccatata tttgaaagaa aaggctcaaa caaaaacaag gacgcctgat gcgaagctcc 138300cagcctgtgg gttctttgcc atgggcctat tggatgggag gtttgggctg caagacaagc 138360tgtgacttta cctccttgaa tgtgctgatt ctaaagagtc gatttcaatc taaggaagga 138420cattgggggg attggaaaaa gtgaagagat tgtacagaag ctcacagcta gcaggtgatg 138480gaggctgagc ccaggagtgc tttttccact ctcccaggct gcttaaaaaa taaattgtat 138540ttgaatgtgc tcacattaat tttgctacca gtttactgtc gtcaaaatag tgtcaatgaa 138600tgcaagttct taaaagacct gcaagtccca cctgggaggt ggggcagcac aggacatgag 138660gagttggtgg tgaatgagaa tttgagaatg ttcaattcat ccctcattag ccatgtgatc 138720tcaggcagcc cgctgatcat ttctgtgtct caggttccta ctctgtgagg gagagagaga 138780gaataattgc accccctttg aatgtaagca tctcccttag gagatgaata cacacggtgg 138840agtgacagta gccaagtttt ttttttttta tactttaagt tttagggtac atgtgcacaa 138900cgtgcaggtt agttacatat gtatacatgt gccatgttgg tgtgctgcac ccattaagtc 138960gtcatttaac attaggtata tctctaaatg ctaccctccc ccctaccccc accccacaac 139020aggccccagt gtgtgatgtt ccccttcctg tgtccatgtg ttctcattgt tcagttccca 139080cctatgagtg agaacatgcg gtgtttggtt ttttgtcctt gtgatagttt gctgagaatg 139140atggtttcca gcttcatcca tgtccctaca aaggacatga actcatcatt ttttatggct 139200gcatagtatt ccatggtgta tatgtgccac attttcttaa tccagtctat cattgttgga 139260catttgggtt ggttccaagt ctttgctatt gtgaatagtg ctgcagtaaa catacgtgtg 139320catgtgtctt tatagcagta tgatttataa tcctttgggt atatacccag taatgggatg 139380gctgggtcaa atggtatttc tagttctaga tccctgagga atcgccacac tgacttccac 139440aatggttgaa ctagtttgca gtcccaccaa cagtgtaaaa gtgttcctgt ttctccacat 139500cctctccagc acctgttgtt tcctgacttt ttaatgatca ccattctaac tggtgtgaga 139560tggtatctca ttgtggtttt gatttgcatt tctctgatgg ccagtgatga tgagcatttt 139620ttcatgtgtt ttttggctgc ataaatgtct tcttttgaga agtgtctgtt catatccttc 139680acccacttgt tgatggggtt gtttgttttt ttcttgtaaa tttgttggag ttcctttctg 139740agctttcagt ttctcatggc ccatatgaga tagtaacggt actcacttcc ccagactatt 139800gcgatgatgg cacgcgatgg ggtgagtggg aggtttatca cacagaataa atgatacctt 139860tggttatttt tagtgctgcc cttatcctgg gtcctaagat tctctgatct cttcctattg 139920ggtgttcgtt tgactagatt ccaagaacaa aaattacttg acccacactg gtagggctag 139980gcaatctttc cagccctcct gggttggcag ctgatggata tcatctgttg gtctcactgt 140040cctttactga ggacactggc aaacttaggg gggttttcat catgatgcca tgcactgaca 140100tcgtgaggca tacctgtctc attacagcag agactcatgt gacctgggaa ccactgcagg 140160tcaaaactac agcgcatgaa agccaggagt ttaccaaatg ggtgcagagg ctgcccaggt 140220gtttgggaat ttattttcat tggaaatttt tatcatttct tcacacataa ggatattagt 140280tataagaagt ctgaattttt tttttcctaa caagtacaaa ctacttacaa aatagttgca 140340aggacaacag aaataatttt ttttttgctg gaccttttga gagtaagttg cctgcatgat 140400atcttgtcat ccctgaatac gaatacttta gtgtgtattt tgtaccaaca caaatatgct 140460cctacacaac cacagtagag ttaacagaat cagataatca acgttgatat attcctaatg 140520cctaattctc agaccctgtt catatttgcc cccagacatc cttaaaaaca aaaggaacca 140580tctcagagct acatgctgca tttggctgtt gtgttttatt aggctccatt cacctggaaa 140640agttcctcag tctttctgtg actttcgtgg ccttgacact ctaatggctc taggccagtt 140700acattgcagg atttccccca gcacggggct gcctgatgct tcctcatgag cagattcagg 140760tttagcgtcc ttggcaggag aacccaggag cgaccctggg accgcctcac tccgtgctct 140820caggtcggca ggactgcaat ttgcccggtt actgacgatg

ttcacactgg tgacctgatg 140880gaggtggtgt ctgtggtttc ttcactcctt tcttcctttg taattaatta gtattacatg 140940gaggactagc ttaaaactgt gtaaatactc tgctcttcat tcaacgttta atttattcat 141000ttatgttgta tttatgtcag tatggatgtg tagttttcta tcttatttat tggattataa 141060cctggaatta tcattactta tcttactgtt cacctttgct ggggtttgga agctgttccc 141120actggcccgt gtgttgtcat tctctgagca ggtcctcaag atgtttctga gtcattgtgg 141180accctgcctg ctctggatca tgggtcagct ggttctccaa aaagagctga atcccaagag 141240gagaatgggc tttagatacc atgatctggg tgtacctcag tgcacagagc tggacagcat 141300atgcatatag acacacacac acacacacac acacacacac acacacagat gtttatgtct 141360atgtttgtct ctagctctgt ctatatggaa agccatgagt tggtgctaat atcttcagtt 141420cactcaagca cctcagagtc caccccactt tcttcctttg tatatttgtg actctcattc 141480acaccctgtg ccacccctgc cattttctat cagcattgcc acctccccct gcacagtccg 141540attccaaatt ctgtatgatc tctgaggcca ggcactggcc tgcatcccag gccagcatcc 141600tccctgccca gtaatgctgt gccattcctg tctggaccat ccgcccacat gaaagcccct 141660tttcctccct tcctacaccg aagccctcct tgccctgccc agaggcacac tttgctccag 141720ctgcttcccc cttaaacccc attcattttt ctgggtgcct gccacccttc cattcagtcc 141780cttcccctgc ttggacactc tctctaccct actcaggctg aaagtcccat ggtcctactc 141840ctgcaggagc ccggtcctca ttgcactggg gctctgacac catgacccag ccatgtggac 141900cgccaccgtc ccctaccaat gcccagctcg ggctcttgca aacctccccc aatcccatcc 141960ttgctcacta tgttcctctg tggtcccttc catcggtgcg gatatccccc ttgtttggat 142020acacacagtg gctttaggat cagattgttc agaaagtgga agacctgaaa aaatgtttta 142080tagttagagc taacttctag aacacactgt cactagaaat tcatcagtga gccctagaga 142140gtagcaggca ggaagatgag ccatgtccct caaatctgca tgtcactcag caaggtctct 142200ggctgtggaa ccaggcatgg gagccaccct gtcccagctc ctgatagaga ctcagtggca 142260gtgacccagc cagtaacctc catcaaagta ttctgcattt agatagactc taccacaccg 142320agctattgcg ggaagcccca tggcttcttt cttactgttc ctcttcaccc actgggtggc 142380tggtgatgat cccccgaggc aggggaaggc agtagtgtca gctcttactc cagggtggtc 142440agggccctta gtgtcctcat ttcgtgcctg aaatctctag aggtgttcat cttgcatgtg 142500ggctacgttg tgtcctccaa cttgcatctc cccagaaccc tgctttattt tctatctcca 142560tttgaatttt tctttttaga ttccacatat gagtgagatc atgcaatatt tttcttactg 142620tgtctggttt attccactta gcataatgtc ctctagcctc atcgatgttg tggcatatgg 142680gatgatctca ttctttatga ggtccaaata acattctgtt gtacatatgt gacattattt 142740attttagttt attattttat ttttccataa ggtattgggg aacaggtgat atttggttac 142800atgagtaggt tcttttgtgg tgatttgtga gattttggcg cacccatcac ctgagcagta 142860tacactgcac catatttgta gtcctttatc cctcatcctc ctcccagcct tccccctaag 142920tcctcaaagt ccgttgtgtc attcttatgc ctttgcatcc tcatagctta gcttccgtat 142980gtcagtggga acacacgatg tttggttttc tgttcctgag ttacttcact tagaataata 143040atctccaatc tcatcgagga atttcttcat ccatttgtct gtcaatggac acttaggtgg 143100tttccatacc ttggctactg taaataatgc tgcagtgcac atgggagtgc caatattttt 143160ataaggtagc catttcctct ctgttggata tatacccaga agagggttgc tgggtcttat 143220ggtagttcta tttttcattt atttaaggaa gctccatttt gttttccaga atggctcttc 143280caatctacat tcctaccaac agtgtacaag aattctcttt tctccacact ctgcaaacat 143340ttatcacttg tctctggtaa tagccatcct aaagggtgta ggtgatatcg cacagtggtt 143400ttgatttgc 143409

Claims

1-22. (canceled)

23. A kit for assessing the risk of vesnarinone-induced granulocytopenia, comprising:an isolated or purified oligonucleotide having a sequence including a genetic polymorphism of a human insulin receptor substrate 2 ("IRS-2") gene that is a T to C conversion at position 96,095 of SEQ ID NO: 18; or a full complement of said oligonucleotide.

24. The kit of claim 23, wherein the isolated or purified oligonucleotide consists of 10 to 35 consecutive nucleotides and which is usable as a primer or probe for identifying the genetic polymorphism that is a T to C conversion at position 96,095 of SEQ ID NO: 18.

25. The kit of claim 23, further comprising restriction enzyme Afa I.

26. The kit of claim 23, further comprising at least one labeling reagent, reagent required for PCR, reaction diluent, standard antibody, buffer, detergent, or reaction stopping solution.

27. The kit of claim 23, further comprising at least one additional isolated or purified oligonucleotide having a sequence including a genetic polymorphism of the human IRS-2 gene.

28. The kit of claim 23, wherein said human insulin receptor substrate 2 ("IRS-2") gene is described by GenBank Accession No. AL162497 (version 20) (SEQ ID NO: 18).

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