43rd week of 2012 patent applcation highlights part 39 |
Patent application number | Title | Published |
20120270145 | ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPING DEVELOPER, TONER CARTRIDGE, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD - An electrostatic charge image developing toner includes a binder resin that contains an amorphous polyester resin and a colorant. The toner satisfies the following expressions: 20 μS/cm≦ρ≦150 μS/cm, and 0.012012-10-25 | |
20120270146 | MAGNETIC TONER COMPOSITIONS - The present disclosure relates to a process for preparing a polyester-based magnetic toner composition. The toner composition includes one or more polyester amorphous binder resins, optionally a crystalline polyester resin, and spherical barium iron oxide particles. In embodiments, the toner is prepared from barium iron oxide particles that are in a dispersion including water and a dispersant. In yet other embodiments, the process may be conducted under an inert gas such as argon to avoid oxidation of the ferromagnetic particles during toner preparation. | 2012-10-25 |
20120270147 | PARTICULATE MATERIAL PRODUCTION METHOD AND APPARATUS, TONER PRODUCTION METHOD AND APPARATUS, AND TONER - The particulate material production method includes vibrating a particulate material composition liquid in a liquid column resonance chamber having at least one nozzle to form a standing wave in the particulate material composition liquid caused by liquid column resonance, so that droplets of the particulate material composition liquid are ejected in a droplet ejection direction from the nozzle so as to fly in a space in a flight direction; feeding a gas in a direction substantially perpendicular to the droplet ejection direction to change the flight direction of the ejected droplets; and solidifying the droplets in the space to produce a particulate material. The particulate material composition liquid includes at least a solvent and a component of the particulate material dissolved or dispersed in the solvent, and the nozzle is located at a location corresponding to an anitnode of the standing wave. | 2012-10-25 |
20120270148 | METHOD OF MANUFACTURING TONER, APPARATUS FOR MANUFACTURING TONER, AND METHOD OF MANUFACTURING RESIN PARTICLE - A method of manufacturing toner includes forming liquid droplets. The forming liquid droplets includes vibrating a toner constituents liquid in a liquid column resonance liquid chamber having a plurality of nozzles to form a liquid column resonance pressure standing wave therein, and discharging the toner constituents liquid from the nozzles. The method further includes solidifying the liquid droplets. The toner constituents liquid includes an organic solvent and toner constituents dissolved or dispersed in the organic solvent. The toner constituents include a resin, a colorant, and a release agent. The nozzles are disposed within an area including an antinode of the liquid column resonance pressure standing wave. One of the nozzles disposed closer to a node of the liquid column resonance pressure standing wave has a smaller outlet diameter than that disposed farther from the node. The toner constituents liquid is applied with a uniform pressure at a vicinity of each nozzle. | 2012-10-25 |
20120270149 | PRODUCTION PROCESS OF TONER FOR ELECTROSTATIC IMAGE DEVELOPMENT - Disclosed is a production process of a toner for electrostatic image development, by which excellent toner particle size-controlling ability and moreover the sharpening of a particle size distribution are achieved. | 2012-10-25 |
20120270150 | SUBSTRATE DISTORTION MEASUREMENT - A substrate distortion measurement apparatus comprising one or more optical detectors arranged to measure the locations of pits or holes provided in a substrate, a memory arranged to store previously determined locations of the pits or holes in the substrate, and a comparator arranged to compare the measured locations of the pits or holes with the previously determined locations of the pits or holes, to determine distortion of the substrate. | 2012-10-25 |
20120270151 | RADIATION SENSITIVE RESIN COMPOSITION AND METHOD OF FORMING AN INTERLAYER INSULATING FILM - The present invention relates to a radiation sensitive resin composition comprising [A] an alkali-soluble resin, [B] a 1,2-quinonediazide compound and [C] a radical trapping agent. | 2012-10-25 |
20120270152 | ALUMINUM SUBSTRATES AND LITHOGRAPHIC PRINTING PLATE PRECURSORS - Electrochemically grained and anodized aluminum supports are treated with a post-treatment coating solution containing a polymer derived at least in part from vinyl phosphonic acid and phosphoric acid. This post-treated support is useful as substrates in the preparation of lithographic printing plate precursors. The post-treatment substrate treatment enables wide latitude in manufacturing and compatibility with silicate-free developers to achieve negligible background staining and oxide attack. | 2012-10-25 |
20120270153 | PHOTORESIST COMPOSITION AND METHOD FOR PRODUCING PHOTORESIST PATTERN - A photoresist composition comprising
| 2012-10-25 |
20120270154 | RESIN AND PHOTORESIST COMPOSITION COMPRISING SAME - The present invention provides a resin comprising a structural unit derived from a compound represented by the formula (I): | 2012-10-25 |
20120270155 | COMPOUND, POLYMERIC COMPOUND, ACID GENERATOR, RESIST COMPOSITION, AND METHOD OF FORMING RESIST PATTERN - There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern
| 2012-10-25 |
20120270156 | Photosensitive Resin Laminate and Thermal Processing of the Same - A method of developing a photocurable printing blank to produce a relief pattern comprising a plurality of relief dots. The photocurable printing blank comprises a backing layer having at least one photocurable layer disposed thereon, a barrier layer disposed on the at least one photocurable layer, and a laser ablatable mask layer disposed on top of the barrier layer. The method includes the steps of (1) imaging the at least one photocurable layer by ablating the laser ablatable mask layer to create the relief pattern on the photocurable printing blank the printing blank to actinic radiation through the barrier layer and mask layer to one or more sources of actinic radiation to selectively crosslink and cure portions of the at least one photocurable layer, wherein the at least one photocurable layer is crosslinked and cured in the portions not covered by the mask layer, thereby creating the relief pattern; (3) developing the printing blank to remove the barrier layer, the laser ablated mask layer and uncured portions of the photocurable layer and reveal the relief pattern. The presence of the barrier layer produces printing dots having desired characteristics. The method can also be used with an analog platemaking process that uses a negative instead of an ablatable mask layer. | 2012-10-25 |
20120270157 | RESIST UNDERLAYER FILM-FORMING COMPOSITION AND METHOD FOR FORMING PATTERN - A resist underlayer film-forming composition includes a polymer including a structural unit shown by a formula (1), and having a polystyrene-reduced weight average molecular weight of from 3000 to 10000, and a solvent. Each of R | 2012-10-25 |
20120270158 | MANUFACTURING METHOD OF METAL STRUCTURE OF FLEXIBLE MULTI-LAYER SUBSTRATE - Disclosed is a metal structure of a multi-layer substrate, comprising a first metal layer and a dielectric layer. The first metal layer has an embedded base and a main body positioned on the embedded base. The base area of the embedded base is larger than the base area of the main body. After the dielectric layer covers the main body and the embedded base, the dielectric layer is opened at the specific position of the first metal layer for connecting the first metal layer with a second metal layer above the dielectric layer. When the metal structure is employed as a pad or a metal line of the flexible multi-layer substrate according to the present invention, the metal structure cannot easily be delaminated or separated from the contacted dielectric layer. Therefore, a higher reliability for the flexible multi-layer substrate can be achieved. A manufacturing method thereof is also provided. | 2012-10-25 |
20120270159 | PATTERNING PROCESS - A negative pattern is formed by applying a resist composition onto a substrate, baking, exposing to high-energy radiation, baking (PEB), and developing the exposed resist film in an organic solvent developer to selectively dissolve the unexposed region of resist film. The resist composition comprising a hydrogenated ROMP polymer comprising recurring units having an acid labile group-protected carboxyl group and recurring units having a lactone structure displays a high dissolution contrast in organic solvent development, and exhibits high dry etch resistance even when the acid labile group is deprotected through exposure and PEB. | 2012-10-25 |
20120270160 | RECREATIONAL FIRE STARTING AID - An apparatus having a regulator fluidly connected to a nozzle by a fuel supply conduit can be fluidly connected to a source of liquefied fuel, such as liquefied petroleum gas. The apparatus can be used to initiate self-sustaining combustion of combustible materials in poor condition. The apparatus can be used to dispense a gaseous jet stream of the fuel through an air space and towards combustible materials for aspirating a portion of the air in the air space. The gaseous stream fuel contacts the combustible materials for mixing the gaseous fuel with air surrounding the combustible materials and with the portion of aspirated air, forming a flammable mixture. The flammable mixture can be automatically ignited by the heat of combustion provided by an open source of ignition adjacent the combustible materials. | 2012-10-25 |
20120270161 | COANDA GAS BURNER APPARATUS AND METHODS - A gas burner apparatus for discharging a mixture of fuel gas, air and flue gas into a furnace space of a furnace is provided. The burner tile includes at least one gas circulation port extending though the wall of the tile. The interior surface of the wall of the tile includes a Coanda surface. Fuel gas and/or flue gas conducted through the gas circulation port follows the path of the Coanda surface which allows more flue gas to be introduced into the stream. The exterior surface of the wall of the tile also includes a Coanda surface for facilitating the creation of a staged combustion zone. Also provided are improved burner tiles, improved gas tips and methods of burning a mixture of air, fuel gas and flue gas in a furnace space. | 2012-10-25 |
20120270162 | COMBUSTION CONTROL SYSTEM - A combustion control system, including a first set of sensors for generating sample data including data representing a sequence of detected images of different samples of a fuel made up of solid particles; a fuel analysis module for controlling a processor of a computing device to: (i) determine attributes for one or more predetermined physical characteristics of the particles in each said sample based on the sample data, and (ii) generate an index value for each said sample based on said attributes, said index value representing a level of combustibility of the particles in each said sample; and a combustion control module for controlling a processor of a computing device to adjust one or more parameters for controlling a combustion process based on changes to said index value over time. | 2012-10-25 |
20120270163 | MULTIPLE ACTIVATION CONTACT LIGHTER - The present invention relates to a lighter. The lighter includes a housing having a supply of fuel, an activating unit movably associated with the housing to selectively ignite the fuel, and at least two separate contact areas such that the user can apply enough force or torque with at least two fingers to overcome the torque/forces required to activate piezo, release the fuel the flame in which the activating unit has at least one internal surface. | 2012-10-25 |
20120270164 | CONTAINER CANDLE, INSERT THEREFOR AND METHOD OF MAKING - A container candle having improved burn performance and fragrance delivery is described. The container candle includes a container, a non-cylindrical insert with wick, and a fill material. The non-cylindrical insert provides auto-centering of the wick in the container candle and even burning of the candle by centrally positioning and retention of the wick in the container. The non-cylindrical insert has a top surface which transitions into tapered side walls which in turn transition to a base having a bottom surface, with the top surface being of a lesser diameter than the diameter of the bottom surface. An upper portion of the wick extends beyond the top surface of the insert. The fill material is situated in the container around the insert in an amount at least substantially sufficient to cover the insert but not cover the upper portion of the wick extending out of the insert. | 2012-10-25 |
20120270165 | HEATING METHOD FOR MAINTAINING A STABLE THERMAL BUDGET - The present invention discloses a heating method for maintaining a stable thermal budget. By following the primary procedure with a virtual procedure in such a manner that the total duration of the whole heating process remains constant, it is beneficial to maintain a stable thermal budget and further to maintain a stable device performance. | 2012-10-25 |
20120270166 | RAPID CONDUCTIVE COOLING USING A SECONDARY PROCESS PLANE - A method and apparatus for thermally processing a substrate is provided. In one embodiment, a method for thermally treating a substrate is provided. The method includes transferring a substrate at a first temperature to a substrate support in a chamber, the chamber having a heating source and a cooling source disposed in opposing portions of the chamber, heating the substrate to a second temperature during a first time period while the substrate is disposed on the substrate support, heating the substrate to a third temperature during a second time period while the substrate is disposed on the substrate support, and cooling the substrate in the chamber to a fourth temperature that is substantially equal to the second temperature during the second time period. | 2012-10-25 |
20120270167 | COVER FOR VITREOUS SILICA CRUCIBLE AND VITREOUS SILICA CRUCIBLE AND METHOD OF HANDLING THE SAME - By providing a method capable of avoiding invasion of starting material powder for crucible into an inner face of the crucible, it is made possible to reliably avoid the invasion of foreign substances into a vitreous silica crucible until an actual use time of the crucible and to handle the crucible with no contamination. A cover | 2012-10-25 |
20120270168 | LAMPHEAD ATMOSPHERE - A method and apparatus for thermal processing of semiconductor substrates is disclosed. Each lamp of a lamp assembly is immersed in a thermally conductive atmosphere comprising oxygen. As the lamps are operated, the oxygen reacts with carbon containing species. Consumed oxygen is replaced over time until the thermal conductivity of the atmosphere falls below a tolerance threshold. The atmosphere is then evacuated and replaced. | 2012-10-25 |
20120270169 | TEMPERATURE-MEASURING SUBSTRATE AND HEAT TREATMENT APPARATUS - A temperature-measuring substrate ( | 2012-10-25 |
20120270170 | THERMAL TREATMENT APPARATUS AND THERMAL TREATMENT METHOD - In a loading area below a vertical furnace of a thermal treatment apparatus, a gas stream flows along a first direction from one side to the other side of the loading area into a first evacuation opening provided in the other side of the loading area. A thermal evacuation part is located, along the first direction, between a first evacuation opening and an upstream end of a substrate holding member located at an unload position that is located between the one side and the other side of the loading area. The thermal evacuation part includes a second evacuation opening that is arranged to oppose at least an upper part of the substrate holding member located at the unload position and evacuates an environment around the substrate holding member located at the unload position. | 2012-10-25 |
20120270171 | Intermediate Panel Ceiling For Conveyor Oven - A conveyor oven is provided. The oven housing has a substantially rectangular box frame, clad with a top wall and side walls downwardly depending from the top wall, and a bottom wall connecting the side walls, all defining an interior baking chamber. The baking chamber is heated by a heat source in excess of 700° F. An endless conveyor transports food items to be baked through the baking chamber. The oven has an intermediate panel ceiling assembly disposed within the baking chamber. The assembly has a plurality of ceiling panel holders mounted above the conveyor and spaced below the top wall, each ceiling panel holder substantially spanning the width of the baking chamber. At least one ceiling panel is held within each ceiling panel holder, which is exposed on both sides to the baking chamber for absorbing and distributing heat in the baking chamber. | 2012-10-25 |
20120270172 | BONE AUGMENTATION DEVICE AND METHOD - A bone augmentation device includes at least one axial member defining a longitudinal axis and a plurality of transverse members. Each transverse member extends from a first end, or removably connected to the at least one axial member to a second end configured for fixation with bone. The transverse members are spaced apart and disposed along the longitudinal axis. The at least one axial member and the transverse members are disposed in a configuration to define a bone graft cavity. Methods of use are also disclosed. | 2012-10-25 |
20120270173 | ALIGNERS FOR INCREMENTALLY MOVING TEETH, AND METHODS AND APPARATUS OF MAKING AND USING SUCH ALIGNERS - Apparatus for repositioning teeth from an initial tooth arrangement to a final tooth arrangement, comprising a series of individual appliances comprising an introductory appliance that conforms to the initial tooth position, and remaining appliances of the series designed to incrementally reposition the teeth from an initial tooth arrangement, through a plurality of intermediate tooth arrangements (if there are any), and to a final tooth arrangement. | 2012-10-25 |
20120270174 | ORTHODONTIC WORKING ARCH WIRE, AND ORTHODONTIC TREATMENT SYSTEM INCLUDING SAID ARCH WIRE - The invention relates to an orthodontic working arch wire ( | 2012-10-25 |
20120270175 | SELF-LIGATING BRACKET FOR ORTHODONTIC TREATMENT - A self-ligating orthodontic bracket assembly has a bracket with an archwire slot extending in a mesial-distal direction for receiving an archwire; a vertical slot extending into the bracket to intersect the archwire slot; and a retentive boss in the vertical slot. A retentive pin slides in the vertical slot between an open position and a closed position. The pin has two parallel legs separated by a space, and a lower cross member extending between the legs. The cross member contacts the retentive boss in the open position to retain the pin in the vertical slot. Camming surfaces on the legs slidably engage the vertical slot to hold the pin in the closed position. | 2012-10-25 |
20120270176 | METHOD FOR PRODUCING A DENTIST TOOL - A method for producing a dentist tool for use in removing tooth structure is provided. The method includes acquiring three-dimensional data relating to a shape of a tooth and part of a neighbouring tooth. The method includes processing the data to determine an overlay fitting the tooth and part of the neighboring tooth. The method further includes processing the data to determine the tooth structure to be removed from the tooth to prepare the tooth for further treatment. The method includes determining first and second guiding edges such that the two edges are spaced apart a distance of at least 0.5 mm and configured to enable a dentist cutting tool to be guided by simultaneously contacting the first and second guiding edges to enable a guided removal of at least partially the predetermined part of tooth structure. The method includes producing the determined overlay having the determined guiding edges. | 2012-10-25 |
20120270177 | DENTAL ULTRASONIC DRUG DELIVERY SYSTEM AND DENTAL ULTRASONIC DRUG DELIVERY METHOD - A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device | 2012-10-25 |
20120270178 | GUIDANCE ASSEMBLY TIP FOR A LIQUID DROPLET SPRAY TEETH CLEAING APPLIANCE - The guidance assembly is used for precise cleaning of interproximal spaces of teeth. The guidance assembly includes a base portion ( | 2012-10-25 |
20120270179 | METHOD OF PROVIDING A PATIENT-SPECIFIC DENTAL FIXTURE-MATING ARRANGEMENT - The present invention relates to a method of providing a patient-specific dental fixture-mating arrangement, such as a dental abutment. According to the method, an arrangement is provided which can only be arranged in one rotational position with respect to a fixture in the jawbone of a patient. The arrangement is designed based on the orientation and inclination of the fixture relative to the jawbone. The invention also relates to a dental implant arrangement, comprising a dental fixture and a final dental restoration having mating indexing means. | 2012-10-25 |
20120270180 | SET OF DENTAL COMPONENTS - According to an aspect of the invention, in a set of male dental components, such as abutment screws, each male dental component has a threaded portion with different core diameter. Each male dental component is to be connected to a mating female dental component, such as an abutment. The smaller core diameter a threaded portion has, the higher friction is provided when the male dental component is finally tightened to its mating female dental component, even though the same insertion torque is applied to all male dental components. | 2012-10-25 |
20120270181 | LOCKING IMPLANT - An implant assembly for supporting a prosthesis, the assembly comprising: a implant comprising: a body portion located at a distal end of the bladed implant; a collar portion located at a proximal end of the implant; a central bore extending through the collar portion and into the implant body portion, the central bore having an engagement portion and comprising a plurality of openings radially disposed with a plurality of blades pivotally connected to the body portion of implant, each blade aligned with one of the plurality of openings and capable of moving between a retracted position to an extended position; and a shaft member, having a proximal section and a distal section, said shaft member configured to engage the central bore thereby causing the plurality of blades to extend radially from the body portion anchoring the implant into the bone structure surrounding the implant body portion. | 2012-10-25 |
20120270182 | DENTITION SCORE - Methods, systems, algorithms, and uses for dentition scores having clinical applicability for an individual patient are described herein. The scores increase as a condition worsens and decrease with treatment. The score can be used to communicate the status of a patient's dentitions to the patient, to an insurer, or to another health care professional. | 2012-10-25 |
20120270183 | METHOD OF TREATING AND/OR PREVENTING CONDITIONS CAUSED BY MICROORGANISMS USING AN ORAL LIGHT DEVICE - Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices. | 2012-10-25 |
20120270184 | ENDODONTIC SEALING COMPOSITION - This invention relates to a composition resulting from the mixture of a solid phase, comprising at least one calcium derivative powder in association with at least one radioopacifier and at least one polymer and optionally at least one non-radioopaque filler, all in powder form; and aqueous phase comprising water, at least one water-reducing agent, and at least one set accelerator; the ratio of solid phase to liquid phase ranging from 1.0 to 2.5, preferably from 1.5 to 2.2, more preferably from 2 to 2.15; said composition having a compressive strength of less than 40 MPa, preferably ranging from 1 to 15 MPa, preferably ranging from about 3 to about 12 MPa; this invention also relates to a kit and a method for the manufacture of the composition, and to a method for treating or retreating a canal root. | 2012-10-25 |
20120270185 | DENTAL APPARATUS - The present invention provides a dental apparatus ( | 2012-10-25 |
20120270186 | MARKSMANSHIP TRAINING AID - An essential element of sharpshooter training is the reduction of quivering of the firearm. Such quivering or jitter is caused by inadvertent movement of the shooter while holding the firearm. Embodiments of the present invention comprise a motion sensing device that is attached to the firearm to produce visual and aural feedback to the shooter on the degree of gun shake. The shooter can thus practice different shooting stances, muscle control, and breathing techniques, and use the feedback from the gun shake sensor to evaluate and adjust these parameters. This training aid improves firearm accuracy without the need for stands, stabilizers, or other aids. The training aid can be rapidly attached to, and removed from any firearm. | 2012-10-25 |
20120270187 | FOOD CONTAINER BEHAVIOR MODIFICATION SYSTEM AND METHOD - A food container behavior modification system and method are provided. The food container behavior modification system includes a series of customized food containers including at least a first food container; a first behavior modifier integral to the first food container; a second food container; and, a second behavior modifier integral to the second food container. | 2012-10-25 |
20120270188 | EDUCATIONAL SYSTEMS - An educational kit including 1) a pre-assembled literary book containing text and a rotating photo sleeve into which photographs relating to the text may be inserted and predesignated space for recording documenting information or an electronic template therefore and 2) a task card including an “activity” section with suggested activities, a' “photo list” section with a search and find challenge, and a “record recording” section with spaces for written recording of the date of the document or a computer program. These kits may be used, in particular in teaching and improving reading skills. | 2012-10-25 |
20120270189 | Link Pencils - Link pencils, pens, or other writing utensils provide an improved method of discretely signaling special needs students in a class room setting. The invention utilizes radio frequency communication by using a transmitting device located inside of a writing utensil pencil that talks to a receiving device located inside a separate writing utensil. Once installed, there is no visible way to distinguish the modified pencils from ordinary pencils. The pencil containing the transmitting device is used by an instructor. The pencil containing the receiving device, which in some embodiments may be a transceiver such as a Bluetooth™ transceiver but without input to transmit a user controlled signal, is meant to be used by a student. When the instructor pushes down on the eraser or end of the writing utensil containing the transmitting device, the device containing the receiving device vibrates or emits light. This signals the student to pay attention. | 2012-10-25 |
20120270190 | Career Selection and Psychological Profiling - A method, software, database and system for determining optimal career choices, psychological profiles (i.e., mental health profiles) and genetic based predispositions of an individual are presented in which an attribute profile of the individual containing genetic and non-genetic attributes is compared against a database containing combinations of genetic and non-genetic attributes that are statistically associated with career, psychological and other genetically influenced attributes derived from other individuals. | 2012-10-25 |
20120270191 | Method and Apparatus for Personal Awareness and Growth - An presentation generator is disclosed for generating presentations for interacting with a user on a personal topic of, e.g., the user's selection, wherein the presentations assist the user in obtaining a greater awareness of his/her motivations and/or behaviors relating to the topic. In one embodiment, the presentation generator generates and presents to the user textual observations, questions, and/or statements for the user's consideration. Such presentations use and/or are consistent with textual descriptions obtained from: (a) the results of one or more personality/motivation test results, and (b) user inputs, e.g., regarding the selected topic together with his/her confidence in the validity of such inputs. The invention organizes the textual descriptions so that outputs to the user can be generated from various personality/motivational perspectives thereby assisting the user in viewing the topic of discussion from different perspectives and thereby becoming more aware of his/her biases, motivations, and/or concerns relating to the topic. | 2012-10-25 |
20120270192 | BEHAVIOR ESTIMATION APPARATUS, BEHAVIOR ESTIMATION METHOD, AND COMPUTER READABLE MEDIUM - An example behavior estimation apparatus includes a detection unit to detect sensing information; a first estimation unit to estimate basic actions of a user; a second estimation unit to estimate behavior data in which a plurality of higher-level behaviors made of a combination of the basic actions is arranged in chronological order; an assignment unit to assign any one of a plurality of work behaviors each indicating a behavior related to work to each of the higher-level behaviors, so as to acquire work data; an evaluation unit to evaluate whether the work data satisfies a predetermined standard; a determination unit to determine, when the work data satisfies the predetermined standard, a name of the work behavior assigned to each of the higher-level behaviors; and a display unit to display information according to the name by the determination unit. | 2012-10-25 |
20120270193 | SPORTS BOARD TRAINING DEVICE - A board training apparatus comprising a platform which has a length, a width, a height, and an upper surface. A convexity is formed in the upper surface. The convexity has a base attached to the upper surface of the platform. The convexity has an upper apical region. In certain embodiments of the apparatus, the base of the convexity comprises pegs which detachably affix or attached into holes formed in the upper surface of the platform. The platform is embodied either as a solid monolith or as a hollow sized for containment of the detached convexity. | 2012-10-25 |
20120270194 | TRAINING DEVICE FOR SIMULATING A SKIING MOTION AND USE THEREOF - A training device has a frame and which is provided with a substantially elongated left-hand pedal element and a substantially elongated right-hand pedal element disposed substantially parallel thereto. A front part of each of the pedal elements is provided with a pedal shaft extending both at an upper side and at a bottom side of the pedal element. The training device may be used by a user to simulate a skiing motion. | 2012-10-25 |
20120270195 | Scalpel Brush - A scalpel brush painting device, comprising a retaining ferrule having two open ends, a plurality of bristles protruding from one of the open ends of the retaining ferrule, and a handle attached to or, in some embodiments, releasably attached to the other of the open ends of the retaining ferrule. The scalpel brush painting device can be utilized to train the fine muscles of a user's hand in similar manner as when making incisions utilizing a scalpel, as when painting on a painting medium, and to train the user's hand for the various grip positions utilized when holding a scalpel. | 2012-10-25 |
20120270196 | SYSTEMS AND METHODS FOR VIRTUAL WOUND MODULES - Wound care systems and methods are disclosed that provide users with interactive instruction for chronic wound care. The system presents a visual depiction of a patient with a chronic wound and a visual depiction of wound characteristics, cross-section of the wound and interactive wound care tools. Further, the system presents a visual map having on-screen graphics representing at least one of tissue consistency, tissue texture, tissue temperature, tissue moisture and tissue tenderness for a virtual chronic wound. At least some of the on-screen graphics represent visual cues for the wound care such that a user is provided with a visual indication of the response of the virtual wound to the care the user virtually provides. Administrators can select care modules to build custom training tutorials. In addition, the system tracks the user interaction with the virtual training to provide feedback to the administrator or the user. | 2012-10-25 |
20120270197 | PHYSIOLOGY SIMULATION GARMENT, SYSTEMS AND METHODS - Physiology simulation garments, systems including physiology simulation garments, and methods of using the same are described herein. | 2012-10-25 |
20120270198 | MECHANICAL EDGE VIDEO APPLICATION AND LEARNING SYSTEM - The system and method of learning technical or scientific content in combination with a video game includes provision of a learning module, provision of a gaming module, execution of actions in each of the learning and gaming modules, and alternating, in response to one or more predetermined learning or gaming conditions, between the learning and gaming modules. | 2012-10-25 |
20120270199 | METHODS AND SYSTEMS FOR ASSESSING LATENT TRAITS USING PROBABILISTIC SCORING - A method and system for assessing a latent trait such as a psychiatric disorder in a test subject. The method includes receiving a test subject's responses to test items that are administered to the test subject to elicit the responses from the test subject. An initial first sub-region probability of the test subject lying within a first sub-region of a first latent trait is determined from the test subject's response to the initial first test item. A subsequent first sub-region probability of the test subject lying within the first sub-region of the first latent trait is then determined using the test subject's response to the subsequent first test item to ascertain a conditional response probability, and using the initial first sub-region probability as a prior first sub-region probability. The method and system can be used to more accurately and/or more rapidly assess one or more latent traits in a test subject. | 2012-10-25 |
20120270200 | Electronic Flash Card Device and Method of Use Thereof for Passive Learning - The electronic flash card device is an apparatus that allows a user to complete a learning objective without a conscious effort. A plurality of such apparatuses is positioned throughout the areas that the user occupies daily. The user then passively views, remembers, and learns a plurality of teaching points that are displayed on the apparatus. Each teaching point has an initial portion, which is shown first, and has associated portion, which is shown second along with the initial portion. For example, if the user knows English and wants to learn Spanish, then the initial portion would be a word in English and the associated portion would be the same word in Spanish. The apparatus can also be used to learn simple arithmetic by first showing the arithmetic problem and then showing the arithmetic problem with its answer. The apparatus continuously displays the plurality of teaching points in a timed sequence. | 2012-10-25 |
20120270201 | Dynamic User Interface for Use in an Audience Response System - An audience response system with dynamic user interfaces and methods of using such an audience response system. The audience response system includes a wireless aggregation point and multiple remote handsets communicatively coupled to that wireless aggregation point. The remote handsets may be used (e.g., by students) to answer questions (e.g., posed by a teacher). At least some of the remote handsets may include user interfaces that include user input interface elements that are configurable via the wireless aggregation point. Additionally, the user interfaces of at least some of the remote handsets may provide feedback to the students regarding their interaction with the remote handsets. | 2012-10-25 |
20120270202 | Pre-Transplant Accommodated Organs Resistant To Anti-Donor Immunity - This invention includes the composition of organ grafts accommodated prior to transplantation and therefore resistant to rejection by preformed antibodies. Accommodation is achieved within the donor animal by administration of sub-lethal levels of accommodation inducing factors derived from animals sensitized to the donor. | 2012-10-25 |
20120270203 | INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT - The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition. | 2012-10-25 |
20120270205 | HIGH-FLUX CHEMICAL SENSORS - The present invention relates to the field of chemical detection. Specifically, the invention provides devices that respond quickly to various target chemical analytes present in the environment. Responses are based on a change in an electrical property (such as impedance or resistance) caused by adsorption or absorption of the target analyte(s) to or in a substrate-free chemical sensing element. The chemical sensing element is composed of a thin, electrically conductive polymer material (due to doping of structural polymer material(s) with electrically conductive particles and/or the use of electrically conductive polymer material(s)), which can allow vapors to pass through with little pressure drop. The chemical sensing material is either suspended in the environment, or emplaced adjacent to one or between two porous membranes, resulting in a sensing patch capable of high gas or vapor flux through the chemical sensing element. | 2012-10-25 |
20120270206 | Systems and Methods for Analyzing Nucleic Acid Sequences - The invention relates to systems and methods for analyzing clinically relevant nucleic acid sequences. | 2012-10-25 |
20120270207 | ANALYTE DETECTION - The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid substrate comprising a bound immobilisation agent and an antibody capture agent and a detectable agent, which can bind to the analyte. The antibody capture agent comprises, at a plurality of sites, a ligand for the immobilisation agent. A complex between the analyte, the antibody capture agent and a detectable agent is formed and immobilised on the solid substrate by binding between the immobilisation agent and the ligand. In some embodiments, the ligand and the immobilisation agent are a binding pair comprising a peptide tag and an anti-peptide tag antibody. | 2012-10-25 |
20120270208 | SYNTHETIC ANTIGENS FOR THE DETECTION OF ANTIBODIES TO HEPATITIS C VIRUS - Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens. | 2012-10-25 |
20120270209 | SYSTEMS, DEVICES, AND METHODS FOR SPECIFIC CAPTURE AND RELEASE OF BIOLOGICAL SAMPLE COMPONENTS - Living cells can be selectively and reversibly bound to functionalized dissolvable material (e.g., cross-linked hydrogel compositions) and subsequently released from the composition as viable cells. In some examples, the cells are released by reducing the degree of cross-linking within a functionalized hydrogel composition and/or dissolving the functionalized hydrogel composition bound to the cells. The functionalized hydrogel compositions can be adhered to silicon- and silicon-oxide containing surfaces, such as glass and aminated silicon. The living cells can be isolated from biological samples, such as blood, by selectively binding certain cells from the sample to the functionalized hydrogel, removing unbound cells and later releasing viable bound cells from the functionalized hydrogel. | 2012-10-25 |
20120270210 | METHOD AND REAGENT FOR GENE SEQUENCE ANALYSIS - Provided is a nucleic acid substrate which has nucleic acid substrate characteristics equivalent to those of dATP, has a low substrate specificity for luciferase, exerts no negative effect on enzymatic reactions such as a complementary-strand synthesis, and therefore is particularly suitable for the pyrosequencing method. As a nucleic acid substrate complementary to nucleotide T, a 7-substituted deoxyribonucleotide triphosphate whose 7-position of a purine group is modified by a substituent is used as a substitute for a nucleotide α-thiotriphosphate analog. | 2012-10-25 |
20120270211 | CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded. | 2012-10-25 |
20120270212 | Methods for Non-Invasive Prenatal Ploidy Calling - The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR. | 2012-10-25 |
20120270213 | SCREENING METHOD FOR CELL AGING - The present invention relates to a method for increasing the chronological lifespan of a cell comprising disrupting the function of at least one of the SAGA1 SLIK and/or SALSA complexes in said cell. | 2012-10-25 |
20120270214 | METHODS FOR LOCALIZED IN SITU DETECTION OF mRNA - The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ. | 2012-10-25 |
20120270215 | PROBE FOR DETECTING POLYMORPHISM IN CYP3A GENE, METHOD OF DETECTING POLYMORPHISM, METHOD OF EVALUATING DRUG EFFICACY, AND REAGENT KIT FOR DETECTING POLYMORPHISM - Provided in the present disclosure is a probe for detecting polymorphism that enables a simple detection of polymorphism in the CYP3A gene with high sensitivity. | 2012-10-25 |
20120270216 | COMPOSITIONS AND METHODS FOR DETECTING AND IDENTIFYING SALMONELLA ENTERICA STRAINS - The present specification describes several novel SNPs of | 2012-10-25 |
20120270217 | RESTRICTION ENDONUCLEASE ENHANCED POLYMORPHIC SEQUENCE DETECTION - Provided in part herein is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Provided also are methods for selectively enriching target nucleic acid, for example, fetal nucleic acid in a maternal sample. In the case of detecting fetal nucleic acid in a maternal sample, a restriction enzyme is introduced that can discriminate between the alleles of a polymorphic site. In some embodiments, the maternal allele is digested and nucleic acid comprising the paternal allele is relatively enriched. | 2012-10-25 |
20120270218 | Method for analyzing cervical lymph node metastasis, and tumor marker for head and neck cancer - Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression level of at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing in a cervical lymph node sample; and comparing the aforementioned expression level with a reference value. Also provided is a tumor marker for head and neck cancer used in the aforementioned method for analyzing cervical lymph node metastasis, including at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing, and/or an expression product of the aforementioned gene and/or an expression level thereof. | 2012-10-25 |
20120270219 | NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES - The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 2012-10-25 |
20120270220 | DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS - The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference. | 2012-10-25 |
20120270221 | Methods of sequencing fluorophore-quencher FRET-aptamers - The present invention describes methods for the production and selecting of single chain (single-stranded) fluorescence resonance energy transfer (“FRET”) DNA or RNA aptamers containing fluorophores (F) and quenchers (Q) at various loci within their structures, such that when its specific matching analyte is bound and the FRET-aptamers are excited by specific wavelengths of light, the fluorescence intensity of the system is modulated (increased or decreased) in proportion to the amount of analyte added. F and Q are covalently linked to nucleotide triphosphates (NTPs), which are incorporated by various nucleic acid polymerases such as Taq polymerase during the polymerase chain reaction (PCR) and then selected by affinity chromatographic, size-exclusion or molecular sieving, and fluorescence techniques. Further separation of related FRET-aptamers can be achieved by ion-pair reverse phase high performance liquid chromatography (HPLC) or other types of chromatography. Finally, FRET-aptamer structures and the specific locations of F and Q within FRET-aptamer structures are determined by digestion with exonucleases and mass spectral nucleotide sequencing analysis. Alternatively, single DNA or RNA intrachain FRET-aptamers can be sequenced and the locations of F and Q within the structure can be determined by nanopore sequencing and the locations of F and Q within the structure can be verified by nucleic acid “combing” coupled to high-powered fluorescence microscopy. | 2012-10-25 |
20120270222 | Method for the Efficiency-Corrected Real-Time Quantification of Nucleic Acids - The present invention concerns a method for the quantification of a target nucleic acid in a sample comprising the following steps: (i) determination of the amplification efficiency of the target nucleic acid under defined amplification conditions, (ii) amplification of the target nucleic acid contained in the sample under the same defined reaction conditions, (iii) measuring the amplification in real-time, (iv) quantification of the original amount of target nucleic acid in the sample by correction of the original amount derived from step (iii) with the aid of the determined amplification efficiency. The efficiency correction of PCR reactions according to the invention for the quantification of nucleic acids can be used for absolute quantification with the aid of an external or internal standard as well as for relative quantification compared to the expression of housekeeping genes. | 2012-10-25 |
20120270223 | OLIGONUCLEOTIDE SEQUENCES THAT IDENTIFY SPECIES OF ANIMAL - The present invention provides a method for identifying animal species, said method comprises a step of amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a primer pair, wherein the animal-specific DNA sequences are derived from a ATP synthase subunit 8 gene or a region proximal thereto of a mitochondrial genome; and a step of detecting the amplified DNA fragment. | 2012-10-25 |
20120270224 | METHOD FOR ACCURATE ASSESSMENT OF DNA QUALITY AFTER BISULFITE TREATMENT - The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment. | 2012-10-25 |
20120270225 | DEVICE AND APPARATUS | 2012-10-25 |
20120270226 | MATCHING OF FORENSIC RESULTS - A method of analysing and comparing a test sample with another sample is provided, wherein: the test sample is analysed, the analysis producing test sample analysis data set; the test sample analysis data set is processed to give a test sample results data set; defining a search term relating to the test sample results data set; obtaining the another sample to compare with the test sample; comparing the another sample result with the search term to inform on the another sample being a potential match with the test sample. | 2012-10-25 |
20120270227 | GLYCINE N-METHYLTRANSFERASE (GNMT) ANIMAL MODEL AND USE THEREOF - The present invention is a method of detecting abnormality of liver in a subject, comprising: (i) measuring expression level of genes consisting of survival and proliferation genes, oncogenes, tumor suppressor genes, one carbon metabolism genes and glycogen storage disease related genes, and (ii) determining expression level of genes are indicative of abnormality of liver function when expression level of the survival and proliferation genes and the oncogenes in sample are higher than in wild-type; and expression level of the tumor suppressor genes, the one carbon metabolism genes, and the glycogen storage disease related genes in sample is lower than in wild-type. | 2012-10-25 |
20120270228 | PREDICTORS OF PATIENT RESPONSE TO TREATMENT WITH EGF RECEPTOR INHIBITORS - The present invention provides methods and compositions to facilitate determining whether an EGFR-expressing cancer in an individual is an EGFR inhibitor-responsive cancer, as well as methods for determining the likelihood that a patient having an EGFR-expressing cancer will exhibit a beneficial response to an EGFR inhibitor therapy. The methods generally involve determining a normalized expression level of a gene product that correlates with EGFR inhibitor responsiveness. | 2012-10-25 |
20120270229 | DEVICE FOR DETECTION OF ANALYTES AND USES THEREOF - Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed. | 2012-10-25 |
20120270230 | MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM - The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same. | 2012-10-25 |
20120270231 | LATTICE-MISMATCHED CORE-SHELL QUANTUM DOTS - The disclosure relates to lattice-mismatched core-shell quantum dots (QDs). In certain embodiments, the lattice-mismatched core-shell QDs are used in methods for photovoltaic or photoconduction applications. They are also useful for multicolor molecular, cellular, and in vivo imaging. | 2012-10-25 |
20120270232 | CHARACTERIZATION OF GRANULOCYTIC EHRLICHIA AND METHODS OF USE - The present invention relates, in general, to methods of screening a sample obtained from a subject for antibodies relating to granulocytic ehrlichia (GE) infection. | 2012-10-25 |
20120270233 | ASSOCIATION OF BIOMARKERS WITH PATIENT OUTCOME - The present method relates to quantification of prognostic and predictive biomarkers of the PDK/AKT/mTOR pathway, such as GSK3β, S6, CREB, PTEN, AKT and mTOR, using AQUA® analysis to estimate both patient risk and benefit of treatment to patients diagnosed with glioblastoma. Unlike traditional IHC, the AQUA® system is objective and produces quantitative in situ protein expression data on a continuous scale. Taking advantage of the power of the AQUA system, the present method provides a highly robust and standardized diagnostic assays that can be used in the clinical setting to provide physicians with reliable prognostic and predictive information. Glioblastoma multiform (GBM) remains one of the most aggressive human cancers, and biomarkers that provide prognostic and predictive information would be extremely valuable to both the physician and the patient. A patient's risk may be determined using the prognostic biomarkers of the present method. Such a prognostic determination will allow physicians to identify patients with a relatively ‘good’ or a relatively ‘poor’ prognosis. The benefit of treating specific patients with a specific therapy, may be determined usin̂ the predictive markers of the present method. Treatment with the AGC-family kinase inhibitor enzastaurin, for example, identifies patients that will likely benefit from treatment or not. | 2012-10-25 |
20120270234 | DDR2 PROTEIN WITH ACTIVATED KINASE ACTIVITY AND PREPARATION METHOD THEREOF - The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase activity by inducing phosphorylations of tyrosines by a co-expression with Src or Src related proteins in host cells, or by H2O2 processing of host cells, or a site directed mutation modifying at least one of tyrosines to other amino acid; and a use thereof as a target material in developing medical drugs for treating a disease caused by an excessively activated DDR2 autophosphorylation and tyrosine kinase activity. | 2012-10-25 |
20120270235 | MEMBRANE BIOSENSOR HAVING MULTI-HOLE FILM ATTACHED THERETO AND METHOD FOR MEASURING IMMUNOLOGICAL REACTION OR ENZYMATIC REACTION USING THE SAME - The present invention relates to a membrane sensor having a multi-hole film attached thereto and a method for measuring immunological reactions or enzymatic reactions using the same. More specifically, the present invention relates to a membrane sensor in which a multi-hole film is joined to the top of a membrane on which receptors are immobilized, and a method for measuring immunological reactions or enzymatic reactions using the same. The present invention makes it possible to adjust the sensitivity of membrane biosensors by adjusting the hole size in the multi-hole film and so makes it possible to measure analytes with a high degree of sensitivity using just a small amount of sample, and makes it possible to simultaneously measure diverse types of analyte by attaching various types of receptor on the membrane sensor. | 2012-10-25 |
20120270236 | VOLTAGE-GATED PROTON CHANNEL, Hv1, AND USES THEREFOR - Nucleic acid and protein sequences relating to a proton channel (HvI) are disclosed. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the HvI gene and protein are disclosed. Also provided are methods of identifying modulators of HvI activity, methods of geno typing subjects with respect to HvI, and methods of diagnosing and treating HvI-mediated disorders. | 2012-10-25 |
20120270237 | METHODS FOR THE IDENTIFICATION OF KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF KINASE PROTEINS - The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins. | 2012-10-25 |
20120270238 | Peptides That Bind the Alpha-Fetoprotein (AFP) Receptor and Uses Thereof - The present invention provides an active binding sequence of mammalian alpha-fetoprotein (AFP) to the receptor of AFP (AFPr or RECAP). The sequence is embodied in peptides comprising Lys-Glx-Glx-Xaa-Leu-Ile-Asn (SEQ. ID. NO: 1) and variants thereof, wherein GIx means GIn or GIu, each GIx being selected independently of the other, and Xaa represents Phe or Leu. The peptides bind a site of the AFP receptor. This peptide can be used as a substitute for AFP in the detection, purification and imagining of RECAF. This peptide, as it binds to RECAF which is elevated in cancer cells, allows for a method of diagnostic determination of cancer or chemotherapeutic delivery using cytotoxic or radiological agents. | 2012-10-25 |
20120270239 | MELANOMA PROGNOSTIC MODEL USING TISSUE MICROARRAYS AND GENETIC ALGORITHMS - The invention provides a method for determining the risk that a patient diagnosed with melanoma will develop a recurrence of melanoma comprising: a) determining the level of expression for each marker of a panel of markers, wherein the panel comprises activating transcription factor 2, p21 | 2012-10-25 |
20120270240 | Detection Reagents for Tyrosine Kinase Activity and Methods of Use Thereof - Dual colored fluorescent indicators of specific tyrosine kinase activity and methods of use thereof are disclosed. | 2012-10-25 |
20120270241 | SYSTEMS AND METHODS FOR EVOLVING ENZYMES WITH DESIRED ACTIVITIES - The present invention provides a new method for engineering or evolving enzymes to have desirable characteristics. Among the desirable characteristics is the ability to control catalytic activity through the use of a trigger molecule that rescues a catalytic site defect introduced during the engineering process. The method includes co-evolving enzyme and substrate to retain or improve substrate binding activity in the absence of catalytic activity. | 2012-10-25 |
20120270242 | IMMUNOCHEMICAL DETECTION OF SINGLE TARGET ENTITIES - The present invention relates to immunochemical visualization and quantification of single target entities, such as single molecules, single molecular structures, single particles, etc. in samples wherein said single entities are immobilized. In particular, the invention relates to methods for visualization and quantification of single units of biological or chemical targets, in particular to immunochemical visualization of single molecules of biological targets in histological samples. The methods of the invention comprise a step of forming discrete deposits of detectable molecules at single target sites of sample mediated by an enzyme with oxydoreductase activity, wherein a single target site comprises a single unit of a target. The invention also relates to assays comprising the present visualization and quantification methods and diagnostic applications of said methods. | 2012-10-25 |
20120270243 | Diagnosing and Managing Venous Thromboembolism and Intracardiac Thrombi Using a Provoked D-dimer Test - The present invention provides methods for diagnosing a venous thromboembolism or intracardiac thrombi in an individual in need of such treatment. A representative method of the present invention comprises the steps of: obtaining a plasma sample from said individual; determining the baseline level of D-dimer in said sample; contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin; and measuring the level of D-dimer is said sample after administering or contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin, wherein a significantly greater concentration of D-dimer after contact with a compound that catalyzes the conversion of plasminogen into plasmin than prior to contact with a compound that catalyzes the conversion of plasminogen into plasmin indicates that said individual has pulmonary embolism or venous thromboembolism. | 2012-10-25 |
20120270244 | Means and Methods for Diagnosing and/or Treating a Subject at Risk of Developing Heart Failure - The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of the subject; (b) comparing the level of the biological marker to a standard level of the same biological marker; and (c) determining whether the level of the marker is indicative of a risk for developing heart failure, wherein the biological marker is Krüppel-Like Factor 15 (KLF-15) and/or lysosomal integral membrane protein-2 (LIMP-2) and/or fragments and/or variants thereof, and/or wherein the biological marker is a gene coding for KLF 15 and/or LIMP-2, and/or fragments and/or variants thereof. The invention further relates to use of the KLF15 and/or LIMP-2 protein, and/or the gene coding for KLF15 and/or LIMP2, and/or fragments, and/or variants of the genes and/or proteins, for the preparation of a medicament for a prophylactic and/or a therapeutic medicament for prevention and/or treatment of heart failure. | 2012-10-25 |
20120270245 | DIAGNOSIS AND RISK STRATIFICATION OF INFECTIONS AND CHRONIC DISEASES OF THE RESPIRATORY TRACT AND LUNGS BY MEANS OF PROVASOPRESSIN, PARTICULARLY COPEPTIN OR NEUROPHYSIN II - The invention relates to a method for diagnosing and/or stratifying the risk of infections or chronic diseases of the respiratory tract and lungs, particularly lower respiratory tract infections and chronic obstructive pulmonary disease. In said method, provasopressin (proAVP) or fragments or partial peptides thereof, especially copeptin or neurophysin II, is/are determined. The invention further relates to suitable biomarker combinations for in-vitro diagnosis. | 2012-10-25 |