33rd week of 2010 patent applcation highlights part 22 |
Patent application number | Title | Published |
20100209916 | Apparatus, System, And Method Using Immiscible-Fluid-Discrete-Volumes - Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure. | 2010-08-19 |
20100209919 | POLYNUCLEOTIDE MARKERS - The invention relates to polynucleotides that are closely linked to the bolting gene or B gene within the sugar beet genome and can be used for the development of molecular markers. The invention further relates to molecular markers and kits comprising said markers that can be used for mapping, identification and isolation of the bolting gene or S gene in the sugar beet genome and to discriminate between the annual and bienniai genotype or between different haplotypes within plant groupings of sugar beet plants exhibiting a biennial genotype. The invention also relates to assays and methods of breeding sugar beet plants involving said markers. | 2010-08-19 |
20100209920 | Gene Expression Profiling in Biopsied Tumor Tissues - The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies. | 2010-08-19 |
20100209921 | Digital Amplification - The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample. | 2010-08-19 |
20100209922 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 2010-08-19 |
20100209929 | MULTIPLE MECHANISMS FOR MODULATION OF JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 2010-08-19 |
20100209930 | PRESERVATION OF CELL-FREE NUCLEIC ACIDS - A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids. | 2010-08-19 |
20100209931 | Compositions for Identifying Novel Compositions for the Treatment of Disease and Methods of Using Same - Disclosed herein are compositions useful for identification of potential therapeutic agents for the treatment of a disorder associated with RAS deregulation or dysregulation. The compositions may be a yeast cell having one or more mutations in an IRA gene or an ERG gene. Also disclosed are methods of using these compositions. | 2010-08-19 |
20100209932 | MicroRNA and Messenger RNA Detection On Arrays - The present teachings provide methods for reverse transcribing, and detecting, a plurality of small nucleic acids such as micro RNAs, from the same reaction mixture as a plurality of messenger RNAs. High levels of multiplexing are provided by the use of a plurality of zip-coded stem-loop reverse transcription primers, along with an oligo-dT-promoter-containing reverse transcription primer, in the same reverse transcription reaction mixture. The resulting products can be amplified in an in vitro transcription reaction, and detected on a solid support such as an array. The present teachings also provide compositions, kits, and devices for performing and detecting the reverse transcription reactions described herein. | 2010-08-19 |
20100209935 | Nucleic Acid Ligand Diagnostic Biochip - A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. The target molecules include, but are not limited to, proteins (cellular, viral, bacterial, etc.) hormones, sugars, metabolic byproducts, cofactor, and intermediates, drugs, and toxins. Contacting the test mixture with the biochip leads to the binding of a target molecule to its cognate nucleic acid ligand. The biochip may then be contacted with a reagent(s) that reacts covalently with proteins and not with nucleic acids. Each protein target in the test mixture may then detected by detecting the presence of the reagent at the appropriate address on the biochip. | 2010-08-19 |
20100209936 | Novel recombinant 15-kDa polypeptide and use of same in detecting human infection with Bartonella henselae - Disclosed are the cloning and expression of a novel antigen of | 2010-08-19 |
20100209937 | FLUORESCENCE MICROSCOPE IN A MICROWAVE CAVITY - The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent molecules as well as interaction with other biomolecules and responses to localized environmental variables in living cells and tissues during the application of a microwave field. | 2010-08-19 |
20100209938 | METHODS AND SYSTEMS FOR DETECTION OF STOICHIOMETRY BY FORSTER RESONANCE ENERGY TRANSFER - Methods to detect stoichiometries of protein complexes and/or interactions between proteins based on detection and quantification of FRET and related systems and compositions. | 2010-08-19 |
20100209939 | BNP(1-32) EPITOPE AND ANTIBODIES DIRECTED AGAINST SAID EPITOPE - The present invention relates to a polypeptide carrying a human BNP(I-32) epitope according to Formula (I): a | 2010-08-19 |
20100209940 | FIBROSIS BIOMARKER ASSAY - Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: | 2010-08-19 |
20100209943 | Measurement Of Protease Activity In Post-Mortem Meat Samples - The present methods and systems relate to the placement on meat surfaces of a dye-linked protease substrate bonded in a defined location to a solid, porous support. Proteases in the meat hydrolyze the substrate, which then releases the dye, which diffuses away so that the extent of diffusion can be determined by imaging. Alternatively, the amount of dye released can be determined by its mobilization into a liquid medium. The present methods and systems also relates to determining the amount of hydrolyzed protein that is present in post-mortem meat samples. Agents which bond to hydrolyzed proteins, but not to unhydrolyzed proteins, are generated, wherein such agents comprise antibodies or aptamers. Such agents are then used in quantitative assays comprising ELISA tests or lateral flow tests. | 2010-08-19 |
20100209944 | ADAMTS-7 AS A BIOMARKER FOR CANCERS OF EPITHELIAL ORIGIN - ADAMTS-7 expression and activity are up regulated in patients that have cancers of epithelial origin. Accordingly, the present invention is directed to methods diagnosis of cancers of epithelial origin (e.g. breast cancer, prostate cancer, bladder cancer, brain cancer and hepatic cancer). In particular, the presence of ADAMTS-7 in a biological sample is indicative of cancer of epithelial origin. Thus, measuring the level of ADAMTS-7 in biological samples (e.g. urine or blood) provides a quick, easy, and safe screen that can be used to diagnose cancer in a patient. | 2010-08-19 |
20100209951 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY - Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I. | 2010-08-19 |
20100209952 | Methods For Diagnosis And Monitoring Of Neurological Disease By Detection Of An Excephalotoxin - Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro-inflammatory diseases, such as Alzheimer's disease (AD), HIV-1-associated dementia (HAD), Creutzfeldt-Jakob disease, Mild Cognitive Impairment, prion disease, minor cognitive/motor dysfunction, acute stroke, acute trauma, or neuro-AIDS. Biochemical detection of encephalotoxin according to the methods of the invention will allow diagnosis of neurological disease in early, presymptomatic stages, thereby allowing early intervention in disease progression as well as identification of subjects or populations at risk for developing neurodegenerative disease. The methods of the invention also provide a mechanism for monitoring progression and treatment of neurological disease. | 2010-08-19 |
20100209953 | METHOD OF DETERMINING CARBONIC ANHYDRASE I ACTIVITY - A method for determining hydrolase activity of carbonic anhydrase I (CAI) in a sample which employs, combination of a substrate and an inhibitor. The substrate is a substrate having higher reactivity with CAI than with CAII selected from 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone, a o-nitrophenyl ester, a p-nitropheylthio ester, and a β-naphthyl ester or a substrate having reactivity with both CAI and CAII selected from the group consisting of a p-nitrophenyl ester and a α-naphthyl ester. The substrate having higher reactivity with CAI than with CAII is a substrate that reacts with CAI in an amount, per amount of enzyme protein, twice or more the amount of substrate reacting with CAII, under identical substrate concentrations and reaction times and that specifically binds to CAI and serves as a substrate for hydrolase activity. The inhibitor is an inhibitor inhibiting a hydrolase other than CA, a CA inhibitor inhibiting both CAI and CAII, or a CA inhibitor inhibiting CAI more potently than CAII. | 2010-08-19 |
20100209954 | METHOD OF IDENTIFICATION AND QUANTIFICATION OF PROTEINS, ISOFORMS OF THE ANGIOTENSIN I CONVERTING ENZYME, MOLECULAR GENETIC MARKER BASED ON SAID PROTEINS, USE OF MENTIONED MARKER, ANALYTICAL METHOD FOR DIAGNOSIS, RISK STRATIFICATION, THERAPEUTICAL DECISION IN CARRIERS OF ARTERIAL HYPERTENSION AND RENAL LESION AND KIT FOR USING IN THE DIAGNOSIE - A method of detecting a predisposition for the development of a kidney lesion in an individual including detecting a presence of at least three angiotensin converting enzyme isoforms in an aliquot of fresh or concentrated biological fluids, cells or tissues obtained from the individual; and quantifying the presence of the at least three antiotension converting enzyme isoforms. | 2010-08-19 |
20100209961 | MICROORGANISM CONCENTRATION PROCESS AND AGENT - A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent. | 2010-08-19 |
20100209962 | Tetranor PGDM: A Biomarker of PGD2 Synthesis In Vivo - The present invention relates to a prostaglandin D | 2010-08-19 |
20100209963 | PHOTO-ELECTRIC DEVICE AND METHOD FOR HIGH THROUGHPUT ACTIVATION, GUIDANCE AND PORATION OF TARGETED CELLS WITH HIGH SPATIAL RESOLUTION - The method includes the steps of generating a spatially and/or temporally localized electric field generated on the photoconductive surface, and selectively activating, guiding or porating targeted (excitable) cells at high throughput with high spatial resolution, applied for example to neurons, cardiac and muscle cells. The spatially and/or temporally localized electric field can be established using spatially and/or temporally patterning light with a diffractive element to generate the spatially localized electric field on the photoconductive surface which is sandwiched between two conductive surfaces and applying a selected voltage difference between the two conductive surfaces. The intensity of the light beam can be varied for different processes of activation, guidance or poration without causing cellular damage. | 2010-08-19 |
20100209964 | METHOD AND APPARATUS FOR ANALYZING SAMPLE - A method for analyzing a sample includes the step of irradiating a reaction portion of a sample BL and a reagent | 2010-08-19 |
20100209967 | PROCESS FOR THE SYNTHESIS OF 9A-HYDROXY-STEROIDS - The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A′- is —CH | 2010-08-19 |
20100209968 | IMMOBILIZED ENZYMES AND USES THEREOF - The present invention generally relates to uses of immobilized enzymes. Immobilized enzymes can be used for various chemical transformations, separations, and purifications and can be used in sensors and diagnostics | 2010-08-19 |
20100209971 | GENERATION OF NUCLEIC ACID MOLECULES - The present invention relates generally to methods for generating single stranded nucleic acid molecules following enhanced solid phase polynucleotide amplification. The present invention employs an amplification reaction using primers with differential priming properties at particular annealing conditions or an immobilized primer nested between two aqueous phase primers. Thus, by primer design, solid support primer participation is enhanced relative to aqueous phase primers. The subject invention further provides methods for labeling solid matrices with single and double stranded nucleic acid molecules. Kits for generating single stranded nucleic acid molecules and for conducting amplification reactions also form part of the present invention. The present invention further provides amplification systems for the generation of single stranded nucleic acid molecules optionally labelled with a reporter molecule and their use inter alia as labels, primers and probes. | 2010-08-19 |
20100209972 | METHOD FOR SYNTHESIS OF SINGLE- OR DOUBLE-STRANDED DNA, AND KIT FOR THE SYNTHESIS - An object of the present invention is to provide a simple and safe method for synthesis of single-stranded or double-stranded DNA and a kit for performing the synthesis. The present invention relates to, (1) a method for synthesis of single-stranded DNA, comprising a nucleotide sequence corresponding to the template RNA, characterized by comprising the following steps: 1) Step 1 in which the template RNA is subjected to reverse transcription reaction, 2) Step 2 in which the solution obtained in the treatment of Step 1 is subjected to alkaline treatment; (2) a method for synthesis of double-stranded DNA, comprising a nucleotide sequence corresponding to the template RNA, characterized by comprising the following steps: 1) Step 1 in which the template RNA is subjected to reverse transcription reaction, 2) Step 2 in which the solution obtained in the treatment of Step 1 is subjected to alkaline treatment, 3) Step 3 in which the obtained single-stranded DNA is converted to a double strand, as well as (3) a kit for synthesis of single-stranded DNA and (4) a kit for synthesis of double-stranded DNA for use in the above-described method for synthesis. | 2010-08-19 |
20100209977 | L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING AN L-AMINO ACID - A bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an amino acid such as L-cysteine and has been modified to have specific mutation in the yeas gene, is cultured in a medium, and the L-amino acid is collected from the medium. | 2010-08-19 |
20100209978 | GENE-DISRUPTED STRAIN, RECOMBINANT PLASMIDS, TRANSFORMANTS AND PROCESS FOR PRODUCTION OF 3-CARBOXYMUCONOLACTONE - Industrial-scale fermentative production of 3-carboxy-cis,cis-muconic acid from terephthalic acid. Also, a protocatechuate 4,5-ring-cleaving enzyme gene-disrupted strain in which the gene coding for (a) the amino acid sequence set forth in SEQ ID NO: 1 or 3, or (b) the amino acid sequence set forth in SEQ ID NO: 1 or 3 which has a deletion, substitution, addition and/or insertion of one or more amino acids and exhibits protocatechuate 4,5-ring cleavage activity, present in the chromosomal DNA of microbial cells, has been disrupted; recombinant plasmids comprising the Tph gene and protocatechuate 3,4-dioxygenase gene; transformants obtained by introducing the recombinant plasmids into the disrupted strain; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of terephthalic acid. | 2010-08-19 |
20100209979 | Method of Manufacturing Glycerol Carbonate - Disclosed is a method of manufacturing a glycerol carbonate (GC). The method includes a bio-catalyst reaction for generating the GC and byproducts generated by reacting a reactant solution using a lipase of a bio-catalyst. In this instance, the reactant solution is prepared by adding glycerol, a glycerol-containing composition, or a dimethyl carbonate (DMC) in a reaction solvent. | 2010-08-19 |
20100209980 | METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALKYLPHENOLS - The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R). | 2010-08-19 |
20100209981 | TRANSAMINASE POLYPEPTIDES - The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds. | 2010-08-19 |
20100209982 | MODIFIED-IMMOBILIZED ENZYMES OF HIGH TOLERANCE TO HYDROPHILIC SUBSTRATES IN ORGANIC MEDIA - Disclosed are preparations of modified interfacial enzymes, particularly lipases and phospholipases, immobilized on a solid support, wherein the enzyme is surrounded by hydrophobic microenvironment, thereby protected from deactivation and/or aggregation in the presence of hydrophilic agents, substrates and/or reaction products. The enzyme may be protected by being covalently bonded with lipid groups which coat the enzyme, or by being immobilized or embedded in a hydrophobic solid support. Also disclosed are processes for the preparation of the hydrophobically protected enzymes. The enzymes may be efficiently used in the preparation of biodiesel. | 2010-08-19 |
20100209985 | NOVEL ESTERASES AND THEIR USE - The present invention relates to polyesterases having cutinase and/or suberinase activity obtainable from | 2010-08-19 |
20100209986 | BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS - Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate. | 2010-08-19 |
20100209987 | Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses - The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z′, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, α-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material. | 2010-08-19 |
20100209988 | Bioremediation Materials - Microbially colonised charred biological material, such as charcoal, wherein the colonising microbes are capable of metabolising at least one selected environmental substance, such as a pollutant, and wherein a selective amount of the substance is present in the charred material provide protected colonies of environmentally active microbes useful in bioremediation, for example. | 2010-08-19 |
20100209991 | IONIC LIQUIDS DERIVED FROM FUNCTIONALIZED ANIONIC SURFACTANTS - A novel class of ionic liquids and methods for their preparation are disclosed. Specifically, these novel ionic liquids can be derived from anionic surfactants, such as alkyl aryl sulfonates, and mid-chain branched derivatives of alkyl sulfates, alkyl alkoxy sulfates, and alkyl aryl sulfonates. In addition, novel ionic liquids can be derived from other anionic surfactants, such as methyl ester sulfonates (MES), alkyl glycerol ether sulfonates, and alpha olefin sulfonates. Anions may be paired with a variety of cations to achieve various advantageous properties. The present invention also relates to compositions containing these novel ionic liquids and method of using the same. | 2010-08-19 |
20100209992 | Process for the production of a catalyst preparation and use of the catalyst preparation - A process is described for the production of a catalyst preparation, in which the catalyst containing at least one inorganic compound which is solid under standard conditions is comminuted by means of a dispersion unit into particles having a maximum average particle size d | 2010-08-19 |
20100209997 | CARBONIC ANHYDRASE POLYPEPTIDES AND USES THEREOF - The present disclosure relates to recombinant carbonic anhydrase enzymes having improved properties as compared to a naturally-occurring wild type carbonic anhydrase and uses thereof for the sequestration of carbon dioxide as well as for the release of carbon dioxide from a composition comprising bicarbonate. Also provided are polynucleotides encoding the recombinant carbonic anhydrase enzymes and host cells capable of expressing the recombinant carbonic anhydrase enzymes. | 2010-08-19 |
20100209998 | CELL-PERMEABILISING PEPTIDES AND POLYPEPTIDES FOR MICROBIAL CELLS - Signal peptides and polypeptides from | 2010-08-19 |
20100210003 | SYSTEM AND RELATED METHOD FOR CONCENTRATING BIOLOGICAL CULTURE AND CIRCULATING BIOLOGICAL CULTURE AND PROCESS FLUID - A system and related method for concentrating biological culture and circulating biological culture and process fluid is provided. The system includes a continuous flow separator that removes excess fluid from the culture medium, resulting in a “concentrated medium” of fluid. The concentrated medium is then passed along for further processing to capture the biomass. The overflow, i.e., the extracted fluid, from the continuous flow separator is reintroduced into the container in a manner to circulate the culture medium. Thus, energy from the concentration step is utilized to circulate the culture medium, alleviating the need for significant additional structure for circulating the culture medium. In this manner, the system grows and captures biological material in an energy and capital efficient manner. | 2010-08-19 |
20100210004 | PLASMODIUM AXENIC LIVER STAGES AS A NONINFECTIOUS WHOLE ORGANISM MALARIA VACCINE - The present invention relates to the treatment and prevention of malaria infection. In particular, the present invention provides novel noninfectious, whole organism vaccines for malaria, which vaccines comprise a | 2010-08-19 |
20100210007 | AUTOMATIC ANALYZER - Disclosed is an automatic analyzer that analyzes a component of a target layer of a test sample separated into a plurality of layers by transferring the component from an installed container, comprising: a dispensing probe that descends into the target layer and suctions the component; a detecting unit that detects the height of the layer surface of the target layer of the test sample; a calculating unit that calculates the depth from the layer surface of the target layer at which the total content of the component of the target layer reaches a target amount; and a controller that causes the dispensing probe to descend to the depth calculated by the calculating unit and suction the component. | 2010-08-19 |
20100210008 | Configurable Microfluidic Substrate Assembly - A microfluidic substrate assembly includes a substrate body having at least one fluid inlet port. At least one microscale fluid flow channel in the substrate is in fluid communication with the inlet port for transport of a fluid to be tested. The substrate body also has a plurality of sockets, with each of one or sockets configured to receive an operative component. At least one socket is in communication with the microscale fluid flow channel. | 2010-08-19 |
20100210015 | PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL - A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell. | 2010-08-19 |
20100210016 | ROTATION SYSTEM FOR CELL GROWTH CHAMBER OF A CELL EXPANSION SYSTEM AND METHOD OF USE THEREFOR - A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip. | 2010-08-19 |
20100210017 | COMPOSITIONS AND METHODS FOR ENHANCING TOLERANCE FOR THE PRODUCTION OF ORGANIC CHEMICALS PRODUCED BY MICROORGANISMS - Embodiments herein generally relate to methods, compositions and uses for enhancing tolerance of production of organic acids and alcohols by microorganisms. This application also relates generally to methods, compositions and uses of vectors having one or more genetic element to increase the tolerance of organic acids or alcohols by a microorganism. Certain embodiments relate to compositions and methods of enhancing the tolerance for production of 3-hydroxypropionic acid (3-HP) by bacteria. In some embodiments, compositions and methods relate to regulating the expression of an inhibitory molecule of an enhancing gene to increase production of organic acid by bacteria. | 2010-08-19 |
20100210018 | MICROBIAL HOST-VECTOR COMPLEMENTATION SYSTEM - This invention provides a host-vector complementation system, which permits selection of vector-carrying host cells, without requiring an antibiotic resistance gene. In some embodiments, this system utilizes a host which is guaB deficient and vectors that carry and express the guaB gene. The invention also discloses methods of making and using the system. | 2010-08-19 |
20100210019 | SAMPLE ANALYZER, SAMPLE ANALYZING METHOD, AND COMPUTER PROGRAM PRODUCT - The present invention is to present a sample analyzer comprising: a reagent container holder; a measurement unit; and an information processing unit configured to perform operations comprising: controlling the measurement unit so as to start the successive measurement of the plurality of samples; determining whether or not to switch from the first reagent container to the second reagent container while performing the successive measurement by using the reagent contained in the first reagent container; controlling the measurement unit so as to suspend a start of aspiration of a next sample, to measure a quality control measurement sample prepared from the reagent contained in the second reagent container, when determined to switch from the first reagent container to the second reagent container; and controlling the measurement unit so as to start the aspiration of the next sample when an analysis result of the quality control measurement sample meets a predetermined condition. | 2010-08-19 |
20100210020 | METHOD FOR ANALYZING DITHIOCARBAMATE PESTICIDE USING MICROWAVE-ASSISTED THERMAL DIGESTION AND EXTRACTION - A method for analyzing a dithiocarbamate pesticide, which can ensure analytical precision with both ease and promptness is provided. The method for analyzing a dithiocarbamate pesticide comprises adding a crude drug, a preparation containing the same, or a treated product thereof, an aqueous acid catalyst solution, L-cysteine or a salt thereof, and an organic solvent for extraction to a reaction vessel, sealing the vessel, carrying out microwave irradiation, digesting a dithiocarbamate pesticide existing in the crude drug or the preparation containing the same into carbon disulfide, carrying out fractional extraction using the above organic solvent, and then analyzing the extract. | 2010-08-19 |
20100210023 | Salivary metabolic biomarkers for human oral cancer detection - The present invention provides a novel oral cancer and periodontal disease salivary metabolome for use in the diagnosis or for providing a prognosis for oral cancer and periodontal disease in an individual. The present invention also provides novel methods of diagnosing or providing a prognosis for oral cancer or periodontal disease by detecting metabolites found in the saliva of an individual. Finally, the present invention provides kits for the detection of salivary metabolites useful in the diagnosis or prognosis of oral cancer and periodontal disease in an individual. | 2010-08-19 |
20100210024 | Methods For Producing Surface Bound Oligonucleotide on Solid Substrate and Uses Thereof - The present invention relates to methods for producing an oligonucleotide on a solid substrate surface and methods for using the same. Some aspects of the invention provide methods for selecting a single DNA molecule reproducibily with an atomic force microscope (AFM). | 2010-08-19 |
20100210025 | Common Module Profiling of Genes - A system for profiling a genomic sequence comprising assigning modules to a genome, wherein each module has a defined sequence characteristic and the genome is divided into modules; assigning a value or weight to a module for a given profile, wherein the presence of one or more modules in a genomic sequence contributes to the profile of the genomic sequence relative to its value or weight; analysing a genomic sequence to identify modules present; and assigning a profile to the genomic sequence based on the presence of the modules and their respective value or weight. | 2010-08-19 |
20100210026 | Alkalinity Determination - Alkalinity determination, including an alkalinity determination process and/or alkalinity determinator. An alkalinity determination process may include providing a known value of volume of an acidic fluid, forming a titration system by providing one or more additions of a known value of volume of a relatively alkaline fluid to an acidic fluid, determining a pH value and/or a temperature value for one or more additions and/or determining an alkalinity value of a system by calculating a transformation including one or more determined pH values and/or temperature values of one or more additions. An alkalinity determination process may include modeling, such that an informed determination may be made with reference to relevant and/or irrelevant factors, as well as parameters to maximize likelihood of alkalinity determination. In embodiments, an alkalinity determinator may include one or more titration cells, one or more sensors and/or one or more alkalinity value determinators. | 2010-08-19 |
20100210029 | DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS - Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity. | 2010-08-19 |
20100210030 | ASSEMBLY OF SEMICONDUCTOR NANOPARTICLE PHOSPHORS, PREPARATION METHOD OF THE SAME AND SINGLE-MOLECULE OBSERVATION METHOD USING THE SAME - Disclosed are an assembly of semiconductor nanoparticle phosphors, which can provide stable evaluation without variation in emission wavelength or in intensity of emission among the particles when used as a labeling agent through which a single-molecule observation is carried out, a preparation method of the assembly, and a single-molecule observation method employing the assembly. Also disclosed is a method for preparing an assembly of semiconductor nanoparticle phosphors according to a liquid phase method, the method comprising the step of reacting a semiconductor precursor at a temperature which is not lower than the melting point of the semiconductor precursor and is not higher than the boiling point of a solvent. | 2010-08-19 |
20100210033 | PORTABLE DEVICE FOR DETECTING FOOD ALLERGENS - The invention relates to a portable device and method for detecting allergenic substances. | 2010-08-19 |
20100210034 | METHODS OF DETERMINING PATIENT RESPONSE BY MEASUREMENT OF HER-3 - The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3. | 2010-08-19 |
20100210035 | HUMAN PROTEINS RESPONSIBLE FOR NEDD8 ACTIVATION AND CONJUGATION - The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and methods for discovering molecules which are useful in detecting and/or modulating the activation and/or conjugation of NEDD8. The present invention arises from the purification and characterization of novel NEDD8 activating and conjugating enzymes. | 2010-08-19 |
20100210036 | PPAR ACTIVE COMPOUNDS - Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. | 2010-08-19 |
20100210039 | SANDWICH IMMUNOASSAY AND MONOCLONAL ANTIBODIES FOR COMP, CARTILLAGE OLIGOMERIC MATRIX PROTEIN - The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic determinants of the COMP molecules are used in the assay. The invention also relates to three particularly advantageous monoclonal antibodies per se that are directed against human COMP. Cell cultures manufacturing these antibodies have been deposited according to the Budapest Treaty at Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH, and have been assigned accesion numbers DSM ACC2406, DSM ACC2408 and DSM ACC2418, respectively. A diagnostic kit comprising at least two of these monoclonal antibodies also constitute a part of the present invention. | 2010-08-19 |
20100210040 | Method and apparatus for reducing the effect of shunting defects on thin film solar cell performance - The present invention provides methods of manufacturing a high efficiency solar cell. In one embodiment, in a solar cell having a grid pattern that channels current, a defect causes an undesired current flow is removed by mechanically removing a portion of the grid pattern, thereby passivating the defect by removing a segment of the solar cell adjacent the defect. The segment also includes the front and back portions of the solar cell at the location of the defect without including the defect. | 2010-08-19 |
20100210049 | METHOD OF MAKING A SEMICONDUCTOR CHIP ASSEMBLY WITH A POST/BASE HEAT SPREADER AND DUAL ADHESIVES - A method of making a semiconductor chip assembly includes providing a post and a base, mounting a first adhesive on the base including inserting the post through an opening in the first adhesive, mounting a conductive layer on the base including aligning the post with an aperture in the conductive layer, providing a conductive trace that includes a pad, a terminal and a selected portion of the conductive layer, then flowing a second adhesive into and downward in a gap between the post and the conductive trace, solidifying the second adhesive, then mounting a semiconductor device on a heat spreader that includes the post and the base, electrically connecting the semiconductor device to the conductive trace and thermally connecting the semiconductor device to the heat spreader. | 2010-08-19 |
20100210050 | METHOD OF MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE - A method of manufacturing a liquid crystal display device | 2010-08-19 |
20100210051 | FACET EXTRACTION LED AND METHOD FOR MANUFACTURING THE SAME - A facet extraction LED improved in light extraction efficiency and a manufacturing method thereof. A substrate is provided. A light emitting part includes an n-type semiconductor layer, an active layer and a p-type semiconductor layer sequentially stacked on the substrate. A p-electrode and an n-electrode are connected to the p-type semiconductor layer and the n-type semiconductor layer, respectively. The p- and n-electrodes are formed on the same side of the LED. The light emitting part is structured as a ring. | 2010-08-19 |
20100210052 | THIN FILM TRANSISTOR PANEL, LIQUID CRYSTAL DISPLAY HAVING THE SAME AND METHOD OF MANUFACTURING THE THIN FILM TRANSISTOR PANEL - A thin film transistor panel, a liquid crystal display having the same, and a method of manufacturing the thin film transistor panel are provided. The thin film transistor includes a gate line formed on an insulating substrate in a predetermined direction, a data line crossing the gate line, a thin film transistor connected to the gate line and the data line, a black matrix formed to overlap at least a portion of the gate line, the data line, and the thin film transistor, a color filter formed in a region partitioned by the black matrix, and a pixel electrode formed on the color filter and electrically connected to the thin film transistor. | 2010-08-19 |
20100210057 | Method for Manufacturing Thin Film Transistor and Method for Manufacturing Display Device - An object is to provide a method for manufacturing a thin film transistor and a display device with reduced number of masks, in which adverse effects of optical current are suppressed. A manufacturing method comprises forming a stack including, from bottom to top, a light-blocking film, a base film, a first conductive film, a first insulating film, a semiconductor film, an impurity semiconductor film, and a second conductive film; performing first etching on the whole thickness of the stack using a first resist mask formed over it; forming a gate electrode layer by side etching the first conductive film in a second etching; forming a second resist mask over the stack; and performing third etching down to the semiconductor film, and partially etching it, using the second resist mask to form a source and drain electrode layer, a source and drain region, and a semiconductor layer. | 2010-08-19 |
20100210058 | METHOD OF MANUFACTURING SEMICONDUCTOR LIGHT EMITTING DEVICE - Disclosed is a method of manufacturing a semiconductor light emitting device. The method includes forming a light emitting structure including a first conductive semiconductor layer, an active layer, and a second conductive semiconductor layer on a substrate, forming an electrode layer on the light emitting structure, forming a conductive support member on the electrode layer, and planarizing a top surface of the conductive support member. | 2010-08-19 |
20100210063 | STACKED-LAYERED THIN FILM SOLAR CELL AND MANUFACTURING METHOD THEREOF - The present invention provides a stacked-layered thin film solar cell and manufacturing method thereof The manufacturing method includes the steps of: providing a substrate, a first electrode layer and a first light-absorbing layer; providing a mask with a plurality of patterns above the first light-absorbing layer; forming an interlayer made of an opaque, highly reflective material by providing the mask on the first light-absorbing layer, wherein the interlayer has a plurality of light transmissive regions corresponding to the patterns, and the light transmissive regions are provided to divide the interlayer into a plurality of units; and then depositing a second light-absorbing layer on the units and a second electrode layer on the second light-absorbing layer. | 2010-08-19 |
20100210064 | METHOD FOR MANUFACTURING CIS-BASED THIN FILM SOLAR CELL - In order to manufacture a CIS-based thin film solar cell that can achieve high photoelectric conversion efficiency by adding an alkali element to a light absorbing layer easily and with good controllability, a backside electrode layer ( | 2010-08-19 |
20100210065 | METHOD OF MANUFACTURING SOLAR CELL - A method of manufacturing a solar cell is provided, which can enhance the carrier concentration, so as to increase the open-circuit voltage, short-circuit current, and fill factor (F.F.), thereby raising the conversion efficiency. The method of manufacturing a solar cell in accordance with the present invention comprises a sputtering step of forming a layer containing Ib and IIIb group elements and Se on a substrate by sputtering with a target containing a Ib group element and a target containing a IIIb group element in an atmosphere containing Se; and a heat treatment step of heating the layer. | 2010-08-19 |
20100210066 | ELECTRODE PASTE FOR SOLAR CELL AND SOLAR CELL ELECTRODE USING THE PASTE - An electrode paste for a solar cell comprising electrically conductive particles, lead-free glass frit, a resin binder and zinc oxide particles, wherein zinc oxide particles having a specific surface area of 6 m | 2010-08-19 |
20100210067 | MIGRATION AND PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION - A method of producing a thin film using plasma enhanced chemical vapor deposition, including the steps of supplying a cation species to a substrate region when there is at most a relatively low flux of a plasma based anion species in the substrate region, and supplying the plasma based anion species to the substrate region when there is at most a relatively low flux of the cation species in the substrate region. This enables delivery of gaseous reactants to be separated in time in PECVD and/or RPECVD based film growth systems, which provides a significant reduction in the formation of dust particles for these plasma based film growth techniques. | 2010-08-19 |
20100210068 | Method of forming phase change memory device - Provided is a method of forming a phase change memory device, the method including washing and rinsing a phase change device structure. A phase change material layer may be formed on a semiconductor substrate. The phase change material layer may be etched so as to form a phase change device structure. The semiconductor substrate on which the phase change device structure is formed may be washed using a washing solution including a reducing agent containing fluorine (F), a pH controller, a dissolution agent and water. In addition, the semiconductor substrate on which the washing is performed may be rinsed. | 2010-08-19 |
20100210071 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICES - A method of manufacturing a semiconductor device. The method includes providing a metal carrier, attaching chips to the carrier, and applying a metal layer over the chips and the metal carrier to electrically couple the chips to the metal carrier. The metal carrier is segmented, after applying the metal layer, to obtain metal contact elements. | 2010-08-19 |
20100210072 | Buffer coating having a physical mixture of high toughness polymer and a low shrinkage polymer - Embodiments of buffer coatings for semiconductor and integrated circuit manufacturing are presented herein. | 2010-08-19 |
20100210077 | CONFIGURABLE INTEGRATED CIRCUIT WITH BUILT-IN TURNS - Some embodiments of the invention provide configurable integrated circuits (“IC's”) with configurable node arrays. In some embodiments, the configurable node array includes numerous (e.g., 50, 100, etc.) configurable nodes arranged in several rows and columns. This array also includes several direct offset connections, where each particular direct offset connection connects two nodes that are neither in the same column nor in the same row in the array. In some embodiments, at least some direct offset connections connect pairs of nodes that are separated in the array by more than one row and at least one column, or by more than one column and at least one row. Some embodiments establish a direct connection by (1) a set of wire segments that traverse through a set of the IC's wiring layers, and (2) a set of vias when two or more wiring layers are involved. In some embodiments, some of the direct connections have intervening circuits (e.g., buffer circuits), while other direct connections do not have any intervening circuits. Also, in some embodiments, the nodes in the configurable array are all similar (e.g., have the same set of circuit elements and same internal wiring between the circuit elements). | 2010-08-19 |
20100210078 | Manufacturing Method of Semiconductor Device - A single crystal semiconductor layer is provided over a base substrate with a second insulating film, a first conductive film, and a first insulating film interposed therebetween; an impurity element having one conductivity type is selectively added to the single crystal semiconductor layer, using a first resist mask; the first resist mask is removed; a second conductive film is formed over the single crystal semiconductor layer; a second resist mask having a depression is formed over the second conductive film; a first etching is performed on the first insulating film, the first conductive film, the second insulating film, the single crystal semiconductor layer, and the second conductive film, using the second resist mask; and a second etching with accompanying side-etching is performed on a part of the first conductive film to form a pattern of a gate electrode layer. | 2010-08-19 |
20100210081 | STRESS MEMORIZATION DIELECTRIC OPTIMIZED FOR NMOS AND PMOS - A method for forming a tensile SiN stress layer for stress memorization enhancement of NMOS transistors with a high Si—H/N—H bond ratio that does not degrade PMOS transistors. | 2010-08-19 |
20100210082 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - A method for manufacturing a semiconductor device comprises forming a dielectric film, and oxidizing the dielectric film. In oxidizing the dielectric film, an oxidized gas is supplied to the dielectric film at a heat treatment. Supplying the oxidized gas is performed intermittently a plurality of times while the dielectric film is subjected to heat treatment. | 2010-08-19 |
20100210083 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - A method of manufacturing a semiconductor device includes forming a first cap film over gate electrodes formed in a first active region and a second active region, etching the first cap film over the first active region, forming a second cap film over the gate electrodes formed in the first active region and the second active region, etching the second cap film over the first active region, etching the first active region using the gate electrodes to form concave portions in the first active region, and embedding a semiconductor material in the concave portions. | 2010-08-19 |
20100210084 | METHODS FOR FABRICATING MOS DEVICES HAVING HIGHLY STRESSED CHANNELS - Methods for forming a semiconductor device comprising a silicon-comprising substrate are provided. One exemplary method comprises depositing a polysilicon layer overlying the silicon-comprising substrate, amorphizing the polysilicon layer, etching the amorphized polysilicon layer to form a gate electrode, etching recesses into the substrate using the gate electrode as an etch mask, depositing a stress-inducing layer overlying the gate electrode, annealing the silicon-comprising substrate to recrystallize the gate electrode, removing the stress-inducing layer, and epitaxially growing impurity-doped, silicon-comprising regions in the recesses. | 2010-08-19 |
20100210089 | SUBSTRATE HAVING THIN FILM OF GaN JOINED THEREON AND METHOD OF FABRICATING THE SAME, AND A GaN-BASED SEMICONDUCTOR DEVICE AND METHOD OF FABRICATING THE SAME - There is provided a method of producing a thin GaN film-joined substrate, including the steps of: joining on a GaN bulk crystalline body a substrate different in type or chemical composition from GaN; and dividing the GaN bulk crystalline body at a plane having a distance of at least 0.1 μm and at most 100 μm from an interface thereof with the substrate different in type, to provide a thin film of GaN on the substrate different in type, wherein the GaN bulk crystalline body had a surface joined to the substrate different in type, that has a maximum surface roughness Rmax of at most 20 μm. Thus a GaN-based semiconductor device including a thin GaN film-joined substrate including a substrate different in type and a thin film of GaN joined firmly on the substrate different in type, and at least one GaN-based semiconductor layer deposited on the thin film of GaN, can be fabricated at low cost. | 2010-08-19 |
20100210090 | FORMING STRUCTURES THAT INCLUDE A RELAXED OR PSEUDO-RELAXED LAYER ON A SUBSTRATE - A method for forming a structure that includes a relaxed or pseudo-relaxed layer on a substrate. The method includes the steps of growing an elastically stressed layer of semiconductor material on a donor substrate; forming a glassy layer of a viscous material on the stressed layer; removing a portion of the donor substrate to form a structure that includes the glassy layer, the stressed layer and a surface layer of donor substrate material; patterning the stressed layer; and heat treating the structure at a temperature of at least a viscosity temperature of the glassy layer to relax the stressed layer and form the relaxed or pseudo-relaxed layer of the structure. | 2010-08-19 |
20100210091 | METHOD FOR PRODUCING A SEMICONDUCTOR - A method for producing a semiconductor includes providing a p-doped semiconductor body having a first side and a second side; implanting protons into the semiconductor body via the first side to a target depth of the semiconductor body; bonding the first side of the semiconductor body to a carrier substrate; forming an n-doped zone in the semiconductor body by heating the semiconductor body such that a pn junction arises in the semiconductor body; and removing the second side of the semiconductor body at least as far as a space charge zone spanned at the pn junction. | 2010-08-19 |
20100210092 | METHOD AND APPARATUS FOR MANUFACTURING SILICON THIN FILM LAYER AND MANUFACTURING APPARATUS OF SOLAR CELL - A method and apparatus for manufacturing a silicon thin film layer and a manufacturing apparatus of a solar cell are disclosed. The manufacturing apparatus of solar cell comprises an outer chamber; an inner chamber disposed within the outer chamber; a container disposed at the inner chamber and which receives a fluid; and a heat exchanger disposed at the outside of the outer chamber and which exchanges heat of the fluid. | 2010-08-19 |
20100210097 | MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - Provided is a manufacturing method of a semiconductor device including a gate insulating film which can be formed into a thin film and of which film composition is easy to be controlled. The manufacturing method includes: forming a manganese oxide film for serving as a gate insulating film on a semiconductor substrate, on which a transistor is formed; forming a conductive film for serving as a gate electrode on the manganese oxide film; and forming a gate electrode and a gate insulating film by processing the conductive film and the manganese oxide film. | 2010-08-19 |
20100210098 | SELF-ALIGNED CONTACT - A method of forming contacts for semiconductor devices, the method including depositing an inter-level dielectric (ILD) over a plurality of gate stacks, in which the divots within the inter-level dielectric layer are defined by the spaces between the gate stacks, filling the divots with an initial fill material, depositing a masking material on the dielectric over the gate stacks, and selectively etching the fill material to form contact vias. The fill material may be a self-assembly material such as a multi-block copolymer in which the blocks self organize vertically within the divots, so that a selective etch of the block material will remove the vertically organized blocks from the divot, but leave at least one block over the gate regions. In another embodiment, the fill material may be a metal, and the masking material may be a parylene based polymer. | 2010-08-19 |
20100210099 | METHODS OF FORMING A METAL SILICIDE LAYER FOR SEMICONDUCTOR DEVICES - Methods of forming a metal silicide layer are provided that include exposing polysilicon through just dry etching (JDE) and recessesing an oxide layer through chemical dry etching (CDE). In particular, dry etching is primarily performed to an extent to expose the polysilicon. Then, CDE is secondarily performed to expose the polysilicon. The CDE process includes selecting an etchant source among combinations of NF | 2010-08-19 |
20100210100 | Semiconductor device and method for manufacturing the same - It is made possible to provide a method for manufacturing a semiconductor device that includes CMISs each having a low threshold voltage Vth and a Ni-FUSI/SiON or high-k gate insulating film structure. The method comprises: forming a p-type semiconductor region and an n-type semiconductor region insulated from each other in a substrate; forming a first and second gate insulating films on the p-type and n-type semiconductor regions, respectively; forming a first nickel silicide having a composition of Ni/Si< | 2010-08-19 |
20100210101 | Formation of Solder Bumps - A method of providing connections to a chip having contact pads on the surface thereof, comprising: locating a discrete solder element on each pad; and melting the discrete solder elements so as to cause each of them to adhere to the respective pad, thereby forming a solder bump extending from the surface of the chip; wherein the size of each discrete solder element relative to the area of the pad on which it is located is such that the height of each bump is less than 70% of the diameter of the solder element that formed it. | 2010-08-19 |
20100210102 | METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE - Aimed at improving adhesiveness between upper and lower interconnects in semiconductor devices, a semiconductor device of the present invention includes a second dielectric multi-layered film formed on a substrate, and containing a lower interconnect; a first dielectric multi-layered film formed on the second dielectric multi-layered film, and having a recess; an MOx film formed on the inner wall of the recess, and containing a metal M and oxygen as major components; an M film formed on the MOx film, and containing the M as a major component; and an electric conductor formed on the M film so as to fill the recess, and containing Cu as a major component, wherein the surficial portion of the interconnect fallen straight under the bottom of the recess has an oxygen concentration of 1% or smaller. | 2010-08-19 |
20100210105 | METHOD OF FABRICATING SEMICONDUCTOR DEVICE HAVING BURIED WIRING - A method of fabricating a semiconductor device can include forming a trench in a semiconductor substrate, forming a first conductive layer on a bottom surface and side surfaces of the trench, and selectively forming a second conductive layer on the first conductive layer to be buried in the trench. The second conductive layer may be formed selectively on the first conductive layer by using an electroless plating method or using a metal organic chemical vapor deposition (MOCVD) or an atomic layer deposition (ALD) method. | 2010-08-19 |
20100210106 | SEMICONDUCTOR DEVICE HAVING A INTERLAYER INSULATION FILM WITH LOW DIELECTRIC CONSTANT AND HIGH MECHANICAL STRENGTH - A method for fabricating a semiconductor includes the steps of forming a porous insulation film and wires on a substrate, the wires embedded in the porous insulation film having a portion adjacent to the wires and a remote portion spaced apart from the wires; and applying an energy beam to the remote portion to change the structure of the porous insulation film such that an Young's modulus of the porous insulation film increased so as to substantially reinforce the strength of the porous insulation film. | 2010-08-19 |
20100210107 | SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF - A semiconductor device and a manufacturing method thereof are provided for the improvement of the reliability of copper damascene wiring in which a film between wiring layers and a film between via layers are comprised of an SiOC film with low dielectric constant. A film between wiring layers, a film between wiring layers, and a film between via layers are respectively comprised of an SiOC film, and stopper insulating films and a cap insulating film are comprised of a laminated film of an SiCN film A and an SiC film B. By doing so, it becomes possible to reduce the leakage current of the film between wiring layers, the film between wiring layers, and the film between via layers, and also possible to improve the adhesion of the film between wiring layers, the film between wiring layers, and the film between via layers to the stopper insulating films and the cap insulating film. | 2010-08-19 |
20100210108 | RADIATION-ASSISTED SELECTIVE DEPOSITION OF METAL-CONTAINING CAP LAYERS - A method for integrating metal-containing cap layers into copper (Cu) metallization of semiconductor devices to improve electromigration and stress migration in bulk Cu metal. In one embodiment, the method includes providing a patterned substrate containing Cu metal surfaces and dielectric layer surfaces, exposing the patterned substrate to a process gas comprising a metal-containing precursor, and irradiating the patterned substrate with electromagnetic radiation, where selective metal-containing cap layer formation on the Cu metal surfaces is facilitated by the electromagnetic radiation. In some embodiments, the method further includes pre-treating the patterned substrate with additional electromagnetic radiation and optionally a cleaning gas prior to forming the metal-containing cap layer. | 2010-08-19 |
20100210111 | PITCH REDUCED PATTERNS RELATIVE TOPHOTOLITHOGRAPHY FEATURES - Differently-sized features of an integrated circuit are formed by etching a substrate using a mask which is formed by combining two separately formed patterns. Pitch multiplication is used to form the relatively small features of the first pattern. Pitch multiplication is accomplished by patterning an amorphous carbon layer. Sidewall spacers are then formed on the amorphous carbon sidewalls which are then removed; the sidewall spacers defining the first mask pattern. A bottom anti-reflective coating (BARC) is then deposited to form a planar surface and a photoresist layer is formed over the BARC. The photoresist is next patterned by conventional photolithography to form the second pattern, which is transferred to the BARC. The combined pattern is transferred to an underlying amorphous silicon layer. The combined pattern is then transferred to the silicon oxide layer and then to an amorphous carbon mask layer. The combined mask pattern, is then etched into the underlying substrate. | 2010-08-19 |