33rd week of 2009 patent applcation highlights part 43 |
Patent application number | Title | Published |
20090203525 | Composition Having a Germination-Preventing Activity, Processes For Obtaining Said Compositions and Use thereof - A composition having a germination-preventing activity, comprising, as active principle, allyl isothiocyanate alone or in combination with other substances having a synergic action, in the form of emulsifiable formulates or as a microencapsulate in which allyl isothiocyanate is englobed in a polymeric-based system for the controlled release of the active principle. The microcapsule membrane represents a weight percentage of 5-25%, the surfactant 2-10% and allyl isothiocyanate a weight percentage not lower than 70%. | 2009-08-13 |
20090203526 | METHOD OF CONTROLLING UNWANTED VEGETATION - The present invention is a method of controlling or preventing unwanted vegetation in a crop planting site by applying a traditionally recognized post-emergent herbicide to a planting site in a pre-emergent application and subsequently applying the same or different traditionally recognized post-emergent herbicide to the planting site in a post-emergent application. Further, a reduction in the amount of a post-emergent herbicide necessary for controlling unwanted vegetation in a crop planting site can be achieved by providing a pre-emergent treatment including a traditionally recognized post-emergent herbicide to the planting site and subsequently providing a post-emergent treatment of a reduced amount of the same or different post-emergent herbicide. | 2009-08-13 |
20090203527 | Preparing Formulations for Treating Agricultural Products - The invention provides an improved method for creating a formulation using a solid chemical agent in solution within a reservoir, and treating crops within a storage facility with an aerosol of the solution substantially at the time of use. The method includes having a premixing section for formulating the solution and mixing solid with a solvent in a premixing section. Further the solution may be heated by circulating it through a substantially instantaneous heater then channeling the solution into a commercial fogger, generating an aerosol of the CIPC solution, and providing said storage facility with said aerosol. | 2009-08-13 |
20090203528 | STABILIZED OIL-IN-WATER EMULSIONS INCLUDING MEPTYL DINOCAP - The present invention relates to stable, agricultural oil-in-water emulsion compositions. | 2009-08-13 |
20090203529 | SUPERCONDUCTING MATERIAL - There are provided superconducting materials ( | 2009-08-13 |
20090203530 | Polymer evolution via templated synthesis - The invention provides a method for producing polymers having a desirable property, for example, catalytic activity or binding activity, via evolutionary nucleic acid-mediated chemistry. | 2009-08-13 |
20090203531 | Method for Archiving and Clonal Expansion - The present method provides methods, libraries, and kits related to the archiving and clonal expansion of sequences related to target polynucleotide sequences. The method allow for the attachment of polynucleotides with defined 3′ and or 5′ sequences to solid surfaces. The polynucleotides attached to the solid substrates can be stored or archived as libraries and can subsequently be retrieved for analysis, for example by clonal expansion. In some embodiments, nucleotides attached to solid surfaces can be used for sequencing of nucleotide sequences related to target RNA or target RNA. The methods are applicable to total RNA and/or total DNA analysis. | 2009-08-13 |
20090203532 | PROCESS FOR GENERATION OF PROTEIN AND USES THEROF - A method of generating a protein with an improved functional property, the method comprising:
| 2009-08-13 |
20090203533 | Methods and Kits for Predicting and Monitoring Direct Response to Cancer Therapy - The invention provides novel compositions, methods and uses, for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia and breast cancer. The invention further relates to genes that are differentially expressed in breast tissue of breast cancer patients versus those of normal “healthy” tissue. Differentially expressed genes for the identification of patients which are likely to respond to chemotherapy are also provided. | 2009-08-13 |
20090203534 | EXPRESSION PROFILES FOR PREDICTING SEPTIC CONDITIONS - A rapid, safe method for predicting sepsis, or a condition similar to sepsis, in a mammal is disclosed, which comprises the following steps:
| 2009-08-13 |
20090203535 | ACOUSTIC WAVE TRANSDUCER SUBSTRATE AND MEASUREMENTS USING THE SAME - An acoustic wave transducer substrate is provided, the substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites. The growth-promotion sites are preferably for promoting fibril formation. The invention also provides a method of screening a candidate compound for an effect on fibril growth, including the steps of: providing an acoustic wave transducer substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites; causing oscillation of the substrate; contacting the substrate surface with a sample fluid comprising polypeptide molecules and a candidate compound; and measuring one or more parameters of the substrate oscillation to monitor the accumulation of said polypeptide molecules of interest in the presence and absence of said candidate compound. Alteration of the accumulation of said polypeptide molecules of interest in the presence of said candidate compound as compared with that in the absence of said candidate compound indicates that the candidate compound has an effect of fibril growth. | 2009-08-13 |
20090203536 | Assay supports comprising a peg support, said support attached from a peg solution in cloud point (theta solvent) conditions - Assay supports, such as microarrays and similar devices, and methods of use and manufacture thereof, are described. The assay support is capable of assaying binding and/or activity of a bioactive entity, such as a bioactive molecule or a cell. Analytical and diagnostic uses of the supports are also described. | 2009-08-13 |
20090203537 | NUCLEAR RECEPTOR ASSAY - The present invention relates to methods for measuring compound efficacy and potency on nuclear receptor-co-regulator interaction, comprising the steps of (a) co-incubating at least one nuclear receptor and at least one compound under conditions that allow interaction; (b) co-incubating the nuclear receptor-compound mixture of step (a) with an array of co-regulators, under conditions that allow compound modulated receptor-co-regulator interaction; (c) determination of compound-modulated receptor-co-regulator interaction in function B of co-regulator concentration, and (d) determination of compound-modulated receptor-co-regulator interaction in function of compound concentration; wherein steps (c) and (d) are performed in a single assay. | 2009-08-13 |
20090203538 | Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same - It is intended to provide a method whereby a plural number of antibodies against cell surface antigens are quickly classified and to provide a method whereby antigens of the thus classified antibodies are quickly identified. Further, it is intended to provide a method of promoting the utilization of the useful data obtained by the above methods. Furthermore, it is intended to provide an antibody which is effective in treating or diagnosing cancer. Namely, a method of classifying antibodies which comprises: (1) the step of preparing a plural number of antibodies respectively recognizing cell surface antigens; (2) the step of bringing each of these antibodies into contact with a cell of the same species; (3) the step of analyzing each of the cells having been treated in the step (2) by flow cytometry and thus obtaining data indicating the reactivity of each antibody with its cell surface antigen; and (4) the step of comparing the thus obtained data and classifying the individual antibodies depending on the similarity. A method of identifying antigens which further comprises: (5) the step of selecting one to several antibodies from each antibody group formed in the step (4) and identifying antigens thereof; and (6) on the assumption that antigens of the antibodies belonging to a single antibody group are the same or highly related to one another, making relations between the antigens having been identified in the step (5) and the antibody groups to thereby identify the antigens. An antibody against HER1, an antibody against HER2, an antibody against CD46, an antibody against ITGA3, an antibody against ICAM1, an antibody against ALCAM, an antibody against CD147, an antibody against C1qR, an antibody against CD44, an antibody against CD73, an antibody against EpCAM and an antibody against HGFR, each obtained by using the above methods. | 2009-08-13 |
20090203540 | Methods and Systems for Quality Control Metrics in Hybridization Assays - The present invention provides methods and systems for performing quality control metrics in hybridization assays. In particular, the present invention provides for quality control metrics for nucleic acid enrichment on hybridization assay formats, such as microarray assays. | 2009-08-13 |
20090203541 | MSP AND ITS DOMAINS AS FRAMEWORKS FOR NOVEL BINDING MOLECULES - Disclosed are compositions and methods relating to the use of MSP94 proteins and its domains as frameworks for novel binding molecules, including screening assays for the identification of novel binding molecules. | 2009-08-13 |
20090203542 | SELECTION SYSTEM - The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein. | 2009-08-13 |
20090203543 | Method for Assaying Enzyme Activity in Histological Sample - The present invention relates to methods for correlating histology and enzymatic activity of a biological sample, the method comprising the steps of: (i) providing a cryopreserved biological sample, wherein said sample comprises a series of consecutively sliced sections; (ii) obtaining histological data of a first subset of said series of sections; (iii) lysing a second subset of sections of said series of sections to obtain a lysate wherein specific enzyme activities are preserved; (iv) assaying the lysate of step (iii) for enzymatic reaction with one or more substrates; and (v) correlating the histology and enzymatic activity of the biological sample. | 2009-08-13 |
20090203544 | METHOD AND USE OF A PRINTER DEVICE FOR PRODUCING BIOLOGICAL TEST ARRAYS - The invention relates to a printer device for producing biological test arrays by depositing an array of biofluids onto a substrate. The invention further relates to the use of such a device in the production of biological test arrays. The invention also relates to a method for producing a biological test array. The invention moreover relates to a biological test array. The method according to the invention is failure-proof, and results in biological test arrays of superior quality. | 2009-08-13 |
20090203545 | EFFICIENT oriP/EBNA-1 PLASMID VECTOR - The invention provides a recombinant vector comprising a DNA segment having a synthetic origin of DNA synthesis that binds EBNA-1 and is capable of initiating DNA synthesis of sequences linked to the synthetic origin of DNA synthesis and maintaining the linked sequences when in the presence of EBNA-1. The synthetic origin of DNA synthesis comprises at least two binding sites for EBNA-1, wherein the two EBNA-1 binding sites are flanked by at least two half-binding sites for TRF2 or at least two binding sites for a protein that enhances the affinity of EBNA-1 for the synthetic origin of DNA synthesis. Further provided are host cells with the vector and methods of using the vector, for instance, ex vivo or in vivo. | 2009-08-13 |
20090203546 | SOLID SUPPORTS FUNCTIONALIZED WITH PHOSPHORUS-CONTAINING DENDRIMERS, PROCESS FOR PREPARING THEM AND USES THEREOF - The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especially biological molecules of interest such as nucleic acids, polypeptides, lipids and proteins. | 2009-08-13 |
20090203547 | Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions - Differences in gene expression between connective tissue cells (e.g., tendon cells) and other closely related cell types are disclosed. Also disclosed are expression profiles between tendon cells under different genetic and environmental influences. The presently disclosed expression profiles are useful as diagnostic markers as well as markers that can be used to monitor disease states, disease progression, injury repair, drug toxicity, drug efficacy, and drug metabolism. | 2009-08-13 |
20090203548 | Complex able to detect an analyte, method for its preparation and uses thereof - A complex able to detect an analyte (CRA) comprising a particle expressing on its outer surface a compound having specific binding capability (CDCLS) for the analyte and stably including at least one nucleic acid reporter sequence being univocally associated to the CDCLS; process for its construction and uses thereof. | 2009-08-13 |
20090203549 | FUNCTIONALIZED PLATFORM FOR ARRAYS CONFIGURED FOR OPTICAL DETECTION OF TARGETS AND RELATED ARRAYS, METHODS AND SYSTEMS - A functionalized platform for a polymer array, comprising a substrate, and a metal oxide layer that attaches a functionalized alkyl phosphonate compound is described together with related array methods and systems. | 2009-08-13 |
20090203550 | METHODS OF MAKING GLYCOMOLECULES WITH ENHANCED ACTIVITIES AND USES THEREOF - Methods to rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, polysaccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second moiety, modifying the structure of the second moiety to provide a modified second moiety, and evaluating or screening the molecule having the modified second moiety, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a polysaccharide. | 2009-08-13 |
20090203551 | Methods and Oligonucleotide Designs for Insertion of Multiple Adaptors Employing Selective Methylation - Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques. | 2009-08-13 |
20090203552 | METHOD OF TWO-DIMENSIONALLY ARRAYING FERRITIN ON SUBSTRATE - A novel method for two-dimensionally arraying ferritin on a substrate is provided which obviates the need for a metal ion that permits linking between adjacent two ferritin particles. In a method of two-dimensionally arraying ferritin on a substrate, the surface of the substrate is hydrophilic, and the method includes the steps of: developing a solution containing a solvent and the ferritin on the substrate; and removing the solvent from the solution developed on the substrate, while the ferritin has an amino acid sequence set out in SEQ ID NO: 1 modified at its N-terminus. | 2009-08-13 |
20090203553 | Sand aggregating reagents, modified sands, and methods for making and using same - A composition for treating solid materials is disclosed, where the treating compositions coats surfaces or portions of surfaces of the solid materials changing an aggregation or agglomeration propensity of the materials. Treated solid materials are also disclosed. The methods and treated materials are ideally suited for oil field applications. | 2009-08-13 |
20090203554 | Well Treatment Compositions Containing Nitrate Brines and Method of Using Same - Brine-based well treatment compositions containing alkali nitrate exhibit greater thermal stability when used in deep wells than substantially similar brine-based well treatment compositions which do not contain an alkali nitrate. The brine is thickened with a water-soluble crosslinkable polymer and crosslinking agent. The enhanced thermal stability of the well treatment compositions allows use of the fluids at elevated temperatures, for instance as high as 400° F. | 2009-08-13 |
20090203555 | Use of Relative Permeability Modifiers in Treating Subterranean Formations - A method for treating a subterranean formation penetrated by a wellbore utilizes forming at least one of a treatment fluid A and a treatment fluid B. The treatment fluid A comprises an aqueous carrier fluid, a first relative permeability modifier (RPM) polymer, a water-soluble viscosifying polymer and a crosslinking agent capable of crosslinking the viscosifying polymer at a pH of from about 3 to about 5. The treatment fluid B comprises a fresh-water carrier fluid and a second relative permeability modifier (RPM), and optionally an amount of fibers. At least one of the treatment fluids A and B is introduced into the formation through the wellbore. | 2009-08-13 |
20090203556 | GELLED HYDROCARBONS FOR OILFIELD PROCESSES, PHOSPHATE ESTER COMPOUNDS USEFUL IN GELLATION OF HYDROCARBONS AND METHODS FOR PRODUCTION AND USE THEREOF - Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters. | 2009-08-13 |
20090203557 | METHOD AND COMPOSITION FOR ENHANCED HYDROCARBONS RECOVERY - The present invention provides a method of treating a hydrocarbon containing formation comprising (a) providing a hydrocarbon recovery composition to at least a portion of the hydrocarbon containing formation, wherein the composition comprises one or more internal olefin sulfonates having 17 or more carbon atoms, (b) adding water and/or brine from the hydrocarbon formation to the composition, (c) adding a solubilizer which comprises an ethoxylated alcohol wherein the alcohol before ethoxylation had an average molecular weight of at least about 220 and (d) allowing the composition to interact with hydrocarbons in the hydrocarbon containing formation. The solubilizer may comprise less than about 0.1 wt %, preferably from about 0.02 to about 0.05 wt %, of the total composition and it may have from about 5 to about 9 moles of ethylene oxide per mole of alcohol. | 2009-08-13 |
20090203558 | METHOD AND COMPOSITION FOR ENHANCED HYDROCARBONS RECOVERY - A method of treating a hydrocarbon containing formation is described. The method includes (a) providing a hydrocarbon recovery composition to at least a portion of the hydrocarbon containing formation, wherein (i) when the salinity of the brine is from about 2 wt % to about 4 wt %, the composition comprises a blend of a C | 2009-08-13 |
20090203559 | Engine Lubrication - A trunk piston or cross-head diesel engine having a centrifuge system including a sealing medium is lubricated with a lubricant which, for the cross-head engine, is a system lubricant and which contains 0.04 to 5 mass %, expressed as active ingredient, of a combination of one or more linked aromatic compounds and one or more nitrogen containing ashless disperants, in a mass:mass ratio in the range of 1:3 to 9:1. | 2009-08-13 |
20090203560 | LUBRICATING COMPOSITION - The present application is directed to a lubricant composition comprising a major amount of a base oil; and a lead corrosion inhibiting amount of a reaction product of a hydrocarbyl carbonyl compound and an amine compound chosen from guanidines, ureas and thioureas; with the proviso that the lubricant is essentially free of zinc dialkyldithiophosphate wear inhibitors, and substantially free of chlorinated paraffins and calcium mannich phenate. | 2009-08-13 |
20090203561 | LUBRICANT COMPOSITION FOR INTERNAL COMBUSTION ENGINE - A lubricating oil composition for internal combustion engines, containing a base oil, (A) at least one compound selected from disulfide compounds represented by the following general formula (I): | 2009-08-13 |
20090203562 | Core Annular Flow of Heavy Crude Oils In Transportation Pipelines and Production Wellbores - A method is provided for enhancing the shear stability of a high-viscosity fluid-water flow system, such as a core annular flow system. The method employs a family of demulsifier additives for maintaining separation of the fluids in biphasic flow. The additive family is sodium salts of polynuclear aromatic sulfonic acids. In one aspect, the high-viscosity fluid is heavy oil. A method of transporting heavy oil through a tubular body is also provided. The method includes pumping the heavy oil through the tubular body within an annular flow of water, and subjecting the water in the tubular body to a salt of a polynuclear, aromatic sulfonic acid additive so as to improve shear stability of the heavy oil and water. | 2009-08-13 |
20090203563 | Method of Preparing an Overbased or Neutral Detergent - The invention provides a process for preparing a neutral or an overbased detergent, the process by: reacting (a) a pre-prepared suspension comprising (i) a metal base with a mean particle size of 10 micrometres or less; (ii) a surfactant; and (iii) an organic medium in which the metal base is suspended typically by a physical process. An overbased detergent may be formed with a further reaction with acidifying overbasing agent. The invention further provides a lubricant composition containing said neutral and overbased detergent. | 2009-08-13 |
20090203564 | Method of cleaning a surface attached with at least one chewing gum lump - The invention relates to a method of cleaning a surface ( | 2009-08-13 |
20090203565 | WATER SOLUBLE BARRIER FILM CONFORMAL COATING COMPOSITION AND METHOD OF CLEANING CONTAMINATED SURFACES - A composition is described having a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1. A method for treating contaminated surfaces of surgical waste management equipment is also described. The method includes rinsing surfaces of the equipment with water to remove water soluble contaminants and waste material. A rinse solution is applied to the surfaces of the equipment to provide a residual film thereon. The rinse solution includes a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1. | 2009-08-13 |
20090203566 | Semi Conductor Process Residue Removal Composition and Process - A composition that includes 2-(2-aminoethylamino)-ethanol, at least one of a chelating agent and a corrosion inhibitor, and water. The composition is capable of removing organic, organometallic and metal oxide residues from semiconductor substrates. The invention also relates to a method of removing etching residue from a semiconductor substrate. | 2009-08-13 |
20090203567 | USE OF ACTIVATOR COMPLEXES TO ENHANCE LOWER TEMPERATURE CLEANING IN ALKALINE PEROXIDE CLEANING SYSTEMS - The present invention provides for the use of activator complexes to enhance lower temperature cleaning in alkaline peroxide cleaning systems. Compositions including an activator complex, an active oxygen source, and a source of alkalinity are applied to the surface to be cleaned at temperatures between about 5° C. and about 50° C. The methods of the present invention provide for enhanced soil removal with reduced energy, water, and chemistry consumption. | 2009-08-13 |
20090203568 | DETERGENT COMPOSITIONS - The present invention relates to detergent compositions comprising a detergent ingredient and a specific lipase variant with reduced potential for odor generation and a good relative performance versus the parent lipase. | 2009-08-13 |
20090203569 | DIMENSIONALLY STABLE SOLID RINSE AID - The present invention is a solid rinse aid composition and methods of making and using the same. The solid rinse aid composition generally includes sodium sulfate and urea as solidification agents and an effective amount of an alcohol ethoxylate compound sheeting agent component and an effective amount of defoamer component. The solid rinse aid composition may also incorporate a preservative system including sodium bisulfate. The solid rinse aid composition may be phosphate-free, aminocarboxylate-free, and GRAS if desired. | 2009-08-13 |
20090203570 | Fabric Conditioner Compositions - A fabric conditioner composition comprising: (g) 0.1-20% by weight cationic fabric conditioner active; (h) 0.1-5% by weight anion quencher selected from mono-long chain quaternary ammonium compound of the general formula R(R1)3N+X- or alkyl benzyl quaternary ammonium compound of a general formula R2R3(R4)2N+X-; (i) 0.1-10% by weight organic acid having from 1 to 8 carbon atoms; where R is selected from C8-C22 alkyl or alkenyl group, R1 is selected from C1-C3 alkyl group, R2 is selected from C6-C18 alkyl or alkenyl group, R3 is benzyl group, R4 is selected from C1-C3 alkyl group, and X is an anion selected from chloride, bromide, iodide, nitrate, sulfate, methyl sulfate, ethyl sulfate, acetate and phosphate. | 2009-08-13 |
20090203571 | Rinse aid compositions with improved characteristics - The present invention is directed to rinse aid compositions with improved biodegradability that may be used in automated carwash operations to promote drying and improve the appearance of vehicles. | 2009-08-13 |
20090203572 | Method for in Vitro Molecular Evolution of Protein Function - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent polynucleotide sequences, the method comprising the steps of (a) providing a first population of polynucleotide molecules and a second population of polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) digesting the first and second populations of polynucleotide molecules with a nuclease to generate polynucleotide fragments, (c) contacting said polynucleotide fragments generated from the plus strands with fragments generated from the minus strands and (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having an altered amino acid sequence as compared to those encoded by the parent polynucleotides, wherein the degree of sequence variability in a selected region of the at least one polynucleotide molecule produced in step (d) is controlled by the addition of one or more oligonucleotides of predetermined variability, which oligonucleotides anneal to a sequence that lies between, but excludes, the 3′ or 5′ terminal nucleotide of the parent polynucleotide molecule. The invention also provides polynucleotides obtained by the method of the invention and polypeptides encoded by the same. | 2009-08-13 |
20090203573 | USE OF DIETARY FIBRES AGAINST MUSCLE WASTING - A composition nutritional containing dietary fibres is useful for the treatment of muscle wasting, if the dietary fibre comprise at least 30 wt. % of galacto-oligosaccharides or other oligosaccharides having mainly anhydropyranose units, and having a chain length of 3-10 units. The composition may further contain other oligo- or polysaccharides, especially polysaccharides having a majority of anhydrofuranose units. | 2009-08-13 |
20090203574 | Method for Modulating Hair Growth - The present invention relates to the use of Lhx2 as a target for modulating the hair growth. Screening assays for identifying agents which increase or decrease the expression or activity of Lhx2 are provided. | 2009-08-13 |
20090203575 | TARGETED THERAPEUTIC PROTEINS - Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided. | 2009-08-13 |
20090203576 | METHODS AND COMPOSITONS FOR PULMONARY DELIVERY OF INSULIN - Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions of the lungs. | 2009-08-13 |
20090203577 | Azepinoindole Derivatives As Pharmaceutical Agents - The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor. | 2009-08-13 |
20090203578 | CERTAIN CRYSTALLINE DIPHENYLAZETIDINONE HYDRATES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR THEIR USE - Provided are certain crystalline hydrates of the formula I | 2009-08-13 |
20090203579 | Glycopegylated Granulocyte Colony Stimulating Factor - The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention. | 2009-08-13 |
20090203580 | Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity - Embodiments herein illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating graft rejection, transplant rejection or diabetes in a subject. Other embodiments herein relate to compounds including naturally occurring and synthetic mutant compositions of alpha-1 antitrypsin, wherein the alpha-1 antitrypsin has no significant serine protease inhibitor activity. | 2009-08-13 |
20090203581 | Novel Peptides for Use in the Treatment of Obesity - The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity. | 2009-08-13 |
20090203582 | LYSOBACTIN AMIDES - The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases. | 2009-08-13 |
20090203583 | Use of Type-B Lantibiotic-Based Compounds having Antimicrobial Activity - The present invention provides methods for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject, the method comprising administering to the subject a type-B lantibiotic. In particular, the invention provides methods for the treatment or prophylaxis of a | 2009-08-13 |
20090203584 | Peptide-based Compounds - The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. | 2009-08-13 |
20090203585 | CAPREOMYCIN DERIVATIVES AND THEIR USE AS ANTIBACTERIALS - The present invention relates to phenylurea derivatives of capreomycin I, IIB, IIA, or IB, and metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial infections by administering such compounds. The present invention also relates to methods of preparing such compounds. | 2009-08-13 |
20090203586 | METHOD FOR AMELIORATING AN INFLAMMATORY SKIN CONDITION - The present invention relates to the use of thioredoxin in the manufacture of a medicament suitable for application to a skin surface for ameliorating an inflammatory skin condition. The present invention further relates to a method of ameliorating an inflammatory skin condition comprising applying to a skin surface an effective amount of a composition comprising thioredoxin. The invention further relates to a pharmaceutical composition suitable for ameliorating an inflammatory skin condition comprising from 0.0001 to 0.5 w/v thioredoxin. | 2009-08-13 |
20090203587 | Diagnosis and Therapy of Cell Proliferative Disorders Characterized by Resistance to Trail Induced Apoptosis - Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and prostate cancer. Furthermore, methods for identifying drugs which are suitable for treatment of such diseases are described. | 2009-08-13 |
20090203588 | Outcome prediction and risk classification in childhood leukemia - Genes and gene expression profiles useful for predicting outcome, risk classification, cytogenetics and/or etiology in pediatric acute lymphoblastic leukemia (ALL). OPAL1 is a novel gene associated with outcome and, along with other newly identified genes, represent a novel therapeutic targets. | 2009-08-13 |
20090203589 | CHEMICALLY MODIFIED HUMAN GROWTH HORMONE RECEPTOR ANTAGONIST CONJUGATES - The present invention provides a chemically modified human Growth Hormone (hGH) receptor antagonists prepared by attaching a single polyethylene glycol moiety to the N-terminus. The chemically-modified protein according to the present invention have decreased PEGylation heterogeneity and which may also have increased binding affinity. | 2009-08-13 |
20090203590 | METHOD FOR THE INHIBITION OF ANGIOGENESIS - The present invention is based on the discovery that Matrilin-1 has antiangiogenic and anticancer properties. The invention is directed to a method of treating a disease that responds to an inhibition of angiogenesis. Additionally, the invention can be applied to those at risk for developing a disease that responds to an inhibition of angiogenesis. The methods comprise administering to a mammal an effective angiogenesis-inhibiting amount of an Matrilin-1 consisting of Matrilin-1, Matrilin-1 fragment, analog, or derivative that is administered in a composition substantially free of other cartilage proteins. | 2009-08-13 |
20090203591 | Methods and compositions for emergency contraception using endothelin receptor antagonists - Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception. | 2009-08-13 |
20090203592 | INFANT NUTRITION WITH HYDROLISED PROTEINS - The invention concerns a method to treat and/or prevent childhood obesity comprising administering a nutritional composition containing fat, digestible carbohydrates and protein, wherein the protein comprises at least 25 wt. % peptides with a chain length of 25 to 30 amino acids based on dry weight of protein. | 2009-08-13 |
20090203593 | Immunogenic Constructs - The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP. In particular, the present invention relates to polypeptides comprising an alipC polypeptide sequence, a gsd polypeptide sequence, a p12 polypeptide sequence and an mpa polypeptide sequence, wherein said ahpC polypeptide comprises the sequence of SEQ ID NO: 2, a variant thereof having more than 70% amino acid sequence identity to SEQ ID NO: 2 across the full length of SEQ ID NO: 2, or a fragment of at least 8 amino acids of SEQ ID NO: 2 which comprises an epitope; said gsd polypeptide comprises the sequence of SEQ ID NO: 6, a variant thereof having more than 70% amino acid sequence identity to SEQ ID NO: 6 across the full length of SEQ ID NO: 6, or a fragment of at least 8 amino acids of SEQ ID NO: 6 which comprises an epitope; said pi 2 polypeptide comprises the sequence of SEQ ID NO: 10, a variant thereof having more than 70% amino acid sequence identity to SEQ ID NO: 10 across the full length of SEQ ID NO: 10, or a fragment of at least 8 amino acids of SEQ ID NO: 10 which comprises an epitope; and said mpa polypeptide comprises the sequence of SEQ ID NO: 14, a variant thereof having more than 70% amino acid sequence identity to SEQ ID NO: 14 across the full length of SEQ ID NO: 14, or a fragment of at least 8 amino acids of SEQ ID NO: 14 which comprises an epitope. Preferably such a variant maintains the ability to generate an immune response against the unmodified polypeptide. | 2009-08-13 |
20090203594 | Anticancer peptide - A polypeptide and methods of using the polypeptide for treating malignancy by administering to a subject a composition of the polypeptide. Pharmaceutical compositions of the polypeptide. | 2009-08-13 |
20090203595 | NEUREGULIN VARIANTS AND METHODS OF SCREENING AND USING THEREOF - The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1β and methods of using polypeptide variants of NRG-1β for treating diseases. | 2009-08-13 |
20090203596 | Phosphatase Inhibitor Protein-1 As A Regulator of Cardiac Function - The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (1-1). In particular, the 1-1 mutant forms comprise altered phosphorylation sites of PKC-α. In addition, the present invention relates to methods of regulating cardiac contractility and function, and for treatment of cardio myopathy and heart failure, which employ the novel nucleic acids and polypeptides. Vectors comprising the novel nucleic acids, Antibodies to the novel proteins, and diagnostic and screening methods associated therewith, are also provided. | 2009-08-13 |
20090203597 | Methods to Restore Glycemic Control - Provided herein are methods and compositions to achieve a sustained delay in the progression of, or an amelioration of diabetes in a subject, or a delay in diabetes onset in a subject at risk for diabetes, comprising an abbreviated course of administration of a pharmaceutical composition comprising an exendin or an exendin agonist analog in an amount effective to induce cell regeneration. | 2009-08-13 |
20090203598 | ABC TRANSPORTER LIGAND - Compositions and methods of using scorpion venom peptide that is a ligand for ABC transporters. One aspect provides a peptide having at least 80% sequence identity to SEQ ID NO: 1. The peptide Is believed to have a molecular mass of about 3.7 kDa and specifically interacts with cystic fibrosis transmembrane conductance regulator. Methods of treating a disorder or symptom of a disorder related to aberrant ABC transporter activity are also provided. | 2009-08-13 |
20090203599 | N-TERMINAL MODIFIED PEG-TRAIL, METHOD FOR PREPARING AND USES THEREOF - Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases. | 2009-08-13 |
20090203600 | PHARMACEUTICAL COMPOSITION FOR THE PROPHYLAXIS AND TREATMENT OF HIV INFECTION AND ITS USE - Pharmaceutical compositions for the prophylaxis and treatment of HIV infection and its use are provided. Particularly, the present invention provides a pharmaceutical composition comprising anti-virus peptides, use of said composition for manufacturing a medicament for the prophylaxis and treatment of HIV infection, and method for preventing and treating HIV infection by using said composition. | 2009-08-13 |
20090203601 | Method for the treatment of neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (G-CSF) variant - The invention relates to a method for treating or preventing neutropenia in a patient receiving chemotherapy by administering a multi-PEGylated granulocyte colony stimulating factor (G-CSF) variant on the same day that chemotherapy is administered. | 2009-08-13 |
20090203602 | Compositions and methods for diagnosis and treatment of type 2 diabetes - The present invention relates generally to the identification of biological markers associated with an increased risk of developing Diabetes, as well as methods of using such biological markers in diagnosis and prognosis of Diabetes. The biological markers of the invention may indicate new targets for therapy or constitute new therapeutics for the treatment or prevention of Diabetes. | 2009-08-13 |
20090203603 | Compositions for the Treatment and Prevention of Nephropathy - Compositions and methods for the prevention and treatment of nephropathy, including hypertensive and diabetic nephropathy, and nephropathy associated with insulin resistance and metabolic syndrome are described. Compositions of the invention include a compound that binds to a receptor for the glucagon like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an exendin, or an analog (including an agonist analog), derivative, or variant of any of them. | 2009-08-13 |
20090203604 | SOOTHING AGENT AND FOOD FOR TREATING FATIGUE - It is an objective of the present invention to provide a soothing agent and a food for treating fatigue whereby: physical strength can be quickly restored from exhaustion (a state with lowered spontaneous motility), such as after exercise or exhausting labor or upon awakening in the early morning; physical strength decline can be prevented; and physical strength can be maintained. | 2009-08-13 |
20090203605 | Methods For Treating A Condition Characterized By Dysfunction In Protein Homeostasis - Methods are provided for treating conditions characterized by dysfunction in protein homeostasis in a patient in need thereof. A method for treating a condition characterized by dysfunction in protein homeostasis in a patient in need thereof is provided which comprises administering to the patient a proteostasis regulator in an amount effective to improve or restore protein homeostasis, and to reduce or eliminate the condition in the patient or to prevent its occurrence or recurrence. The condition can be a loss of function disorder such as a lysosomal storage disease, or a gain of function disorder such as an aging associated disease. | 2009-08-13 |
20090203606 | Systems for and Methods of use of Therapeutic Nutrition for the Management of Age-Associated and Age-Specific Health Conditions of the Elderly - Nutritional compositions which provide for improved taste profiles for the elderly while simultaneously providing nutrition specific to assist in the management of nutritional deficiencies that lead to age specific and age associated health conditions in the elderly. There are also provided products using these compositions and incorporating packaging design, volume delivery, and sensory attributes to improve nutritional regimen compliance in the elderly. | 2009-08-13 |
20090203607 | Method And Compositions For Simultaneously Regulating Memory And Mood - The present invention is concerned with methods and compositions for simultaneously treating or modulating memory and mood within the same individual. | 2009-08-13 |
20090203608 | Novel Proteins and Use Thereof - The present invention provides a novel secretory/membrane protein associated with adipocyte differentiation and/or metabolism function, specifically, an adipocyte-derived secretory/membrane protein containing amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 or 22, a nucleic acid encoding it, an antibody therefor, a method of screening prophylactic and/or therapeutic agents for diseases involving abnormality of adipocyte differentiation/metabolism function using it and/or a kit for the screening, a prophylactic and/or therapeutic agent for the diseases or a diagnostic agent containing the membrane protein. | 2009-08-13 |
20090203609 | Use of IL-1 inhibitors for treating IL-1 mediated diseases - The invention relates to methods for treating or preventing arthritis. The method comprises administering to patients in need thereof therapeutically effective amounts of an IL-1 inhibitor and methotrexate. In a preferred embodiment, the IL-1 inhibitor is human recombinant IL-1ra and the methotrexate is N-[4-[(2,4-diamino-6-pteridinyl)methylamino]benzoyl]-L-glutamic acid. The invention also relates to pharmaceutical compositions containing an IL-1 inhibitor and methotrexate useful in such methods. | 2009-08-13 |
20090203610 | METHODS OF TREATING OBESITY OR DIABETES USING NT-4/5 - The invention concerns methods for treating obesity, non-insulin dependent diabetes mellitus, metabolic syndrome, and other related diseases by administering an NT-4/5 polypeptide. The invention also concerns compositions and kits comprising an NT-4/5 polypeptide. | 2009-08-13 |
20090203611 | ANTI-MICROBIAL DEFENSIN-RELATED PEPTIDES AND METHODS OF USE - An antimicrobial peptide and its analogs that are insensitive to physiological salt and divalent cation concentrations is provided, as are methods for their use to treat and prevent bacterial infections. The peptides are especially useful to treat infections caused by bacteria that are resistant to traditional antibiotic therapy. | 2009-08-13 |
20090203612 | XENORHABDUS TC PROTEINS AND GENES FOR PEST CONTROL - The subject invention relates to novel | 2009-08-13 |
20090203613 | SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE - The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also includes a transfer device having a cannula with a first end and a second end. The first and second ends are adapted to puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. | 2009-08-13 |
20090203614 | USE OF AGENTS THAT PREVENT THE GENERATION OF AMYLOID-LIKE PROTEINS AND/OR DRUSEN, AND/OR USE OF AGENTS THAT PROMOTE SEQUESTRATION AND/OR DEGRADATION OF, AND/OR PREVENT THE NEUROTOXIC EFFECTS OF SUCH PROTEINS IN THE TREATMENT OF MACULAR DEGENERATION - The present invention provides compositions and methods for treating age-related macular degeneration (AMD). More specifically, the methods of the invention target amyloid proteins and drusen that tend to accumulate in the eyes of those patients suffering from AMD. AMD is treated in the methods of the invention by providing agents that sequester and/or degrade such amyloid deposits and/or drusen such that a patient's vision is improved or restored. | 2009-08-13 |
20090203615 | USE OF ACTIVITY DEPENDENT NEUROTROPHIC FACTOR FOR ENHANCING LEARNING AND MEMORY: PRE-AND POST-NATAL ADMINISTRATION - The present invention provides methods for improving performance (e.g., learning and/or memory) using ADNF polypeptides, by treating the subject prenatally or postnatally with an Activity Dependent Neurotrophic Factor (ADNF) polypeptide in an amount sufficient to improve postnatal learning and/or memory of the subject. | 2009-08-13 |
20090203616 | METHODS FOR TREATING PAIN AND SCREENING ANALGESIC COMPOUNDS - The present invention relates to the use of compounds that block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block the α9α10 subtype of the nAChR. | 2009-08-13 |
20090203617 | CHIMERIC PEPTIDES FOR THE REGULATION OF GTPASES - Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene. | 2009-08-13 |
20090203618 | Analog compounds of analgesic peptides derived from the venom of crotalus durissus terrificus snakes, their uses, compositions, methods of preparation and purification - The present invention refers to analog compounds of peptides having the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, including analgesic peptides derived from snakes of species such as | 2009-08-13 |
20090203619 | Artificial platelets - Therapeutic agents suitable for use as artificial platelets are described. The agents comprise a fibrinogen binding precursor bound to an insoluble carrier, wherein the fibrinogen binding precursor can be converted by a wound site specific agent, such as thrombin, to a fibrinogen binding component bound to the carrier. The fibrinogen binding component has increased ability to bind fibrinogen compared to the fibrinogen binding precursor. The agents may be used to treat patients with deficiencies in their own platelets, such as hereditary or acquired defects of platelet numbers (thrombocytopenia) or function (thrombasthenia). | 2009-08-13 |
20090203620 | METHODS FOR ATTENUATING RELEASE OF INFLAMMATORY MEDIATORS AND PEPTIDES USEFUL THEREIN - The present invention includes methods of inhibiting or suppressing cellular secretory processes. More specifically the present invention relates to inhibiting or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from granules in inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. Peptide fragments and variants thereof of MANS peptide as disclosed in the present invention are useful in such methods. | 2009-08-13 |
20090203621 | Tripeptides that Down Regulate the Activity of Plasma Membrane transporters Including Sodium-D-Glucose Cotransporter Sglt1 - The present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein said RS1 fragment is characterized in comprising at least the amino acid sequence Q-C-P (Glutamine-Cysteine-Proline) or derivatives thereof. Furthermore, the present invention relates to a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, said method comprising administering to a patient in need of such amelioration, prevention and/or treatment a pharmaceutically active amount of a regulatory protein RS1 fragment or a nucleic acid molecule encoding a regulatory protein RS1 fragment, wherein said RS1 fragment is characterized in comprising at least the amino acid sequence Q-C-P (Glutamine-Cysteine-Proline) or derivatives thereof. Moreover, the present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of food and/or food supplements. | 2009-08-13 |
20090203622 | METHOD OF TREATING METASTATIC STAGE PROSTATE CANCER - The invention provides methods and dosing regimens for treating metastatic stage prostate cancer in a subject using degarelix, as well as related methods of using degarelix in a subject identified as having metastatic stage prostate cancer, and methods of using degarelix to prevent or delay the progression of locally advanced prostate cancer. | 2009-08-13 |
20090203623 | METHOD OF TREATING PROSTATE CANCER WITH GnRH ANTAGONIST - The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. | 2009-08-13 |
20090203624 | ALPHA-FETOPROTEIN PEPTIDES - The invention relates to compounds that include peptides that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer. | 2009-08-13 |
20090203625 | Phage Display Selection of Anti Fungal Peptides - A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions containing peptides identified using the method of the present invention. In addition, isolated polynucleotides, vectors, expression cassettes and transformed cells capable of expressing peptides identified by the method of the present invention are provided. | 2009-08-13 |