Class / Patent application number | Description | Number of patent applications / Date published |
623100390 | Having pores | 38 |
20080215136 | DIFFERENTIAL DRUG RELEASE FROM A MEDICAL DEVICE - The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrate and/or coating having a plurality of pores, dispersed in said pores are a plurality of a first and second therapeutic agents, wherein said first therapeutic agent is bonded to one or more molecule(s) of a first material and the second therapeutic agent bonded to one or more molecule(s) of a second material, such that when the medical device, is in use (e.g., implanted into a body lumen such as a blood vessel), bonded first therapeutic agent is released from the medical device at a rate that is slower than the rate at which the bonded second therapeutic agent is released from the medical device. | 09-04-2008 |
20080243234 | Magnesium Alloy Stent - A method for treating a vascular condition includes delivering a magnesium alloy stent framework to a target region of a vessel, leaching at least a portion of magnesium from the magnesium alloy stent framework, and forming a plurality of pores within the stent framework of the stent based on the leaching. | 10-02-2008 |
20080249615 | STENTS WITH CERAMIC DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME - A method of making a drug eluting stent comprises forming a porous stent body surface layer by ion implantation, applying a layer of ceramic particles on the porous layer and compressing the layer of ceramic particles. The layer of ceramic particles can be compressed to successively higher densities. Drugs can be loaded into the layer of ceramic materials at a relatively low density before the layer of ceramic materials is compressed to a higher density to achieve a desired low drug release rate. | 10-09-2008 |
20080249616 | Reinforced Porous Coating - The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps: -providing a support having a surface, -depositing on said surface one mono-layer of temporary particles, -depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, -eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a part of the pores communicating with the external environment, -applying a coating fixation step, characterized by the fact that said temporary particles are deposited on said surface in such a way that, after particle deposition, more than 50% of the temporary particles are in contact with a maximum of two adjacent particles and otherwise are separated by an empty space. The invention also concerns a coating and an object which can be obtained with this process. | 10-09-2008 |
20080306584 | Implantable medical devices for local and regional treatment - Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed. | 12-11-2008 |
20090048666 | Medical devices having porous carbon adhesion layers - According to an aspect of the present invention, medical devices are provided which comprise a substrate, a porous carbon layer disposed on at least a portion of the substrate surface, and a polymeric layer disposed on at least a portion of the porous carbon layer. | 02-19-2009 |
20090118817 | Magnetic Medical Apparatus, Kits, and Methods - Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed. | 05-07-2009 |
20090192592 | POROUS IMPLANT STRUCTURE - Exemplary embodiments of the present invention relate to an implant, e.g., a stent, and in particular to a stent having at least one section made of a material having a particular porous structure. | 07-30-2009 |
20090210050 | Implantable Device For Promoting Repair Of A Body Lumen - An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed. | 08-20-2009 |
20090319032 | ENDOPROSTHESIS COATING - An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), that includes a porous surface and hollow elements integrated with a coating on the surface and a method of making the same are disclosed. | 12-24-2009 |
20090326644 | PLANAR STRUCTURE AND METHOD FOR PRODUCING A PLANAR STRUCTURE - The invention relates to a planar structure made of fibers adhered to each other in certain locations, characterized in that the adhesions and/or fibers are broken by an ultrasound treatment. Such planar structures are utilized particularly in the medical field as vascular prostheses or tissue patches. | 12-31-2009 |
20100010624 | VASCULAR STENTING FOR ANEURYSMS - Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow. | 01-14-2010 |
20100070026 | STENT WITH POROUS MEMBRANE AND MANUFACTURING METHOD THEREOF - A dipping bath contains a polymer solution. Stent body members are dipped into the polymer solution. The polymer solution forms membrane on the surface of the stent body member. Humid atmosphere is created around the stent body members with the membrane to condense water vapor into water droplets on the surface of the membrane. After growing the water droplets to water drops, a solvent is evaporated, and the water drops penetrate into the membrane. Then, the water drops are evaporated with leaving pores in the membrane. The water drops function as templates. | 03-18-2010 |
20100087914 | Implant and Method for Manufacturing Same - The present invention proposes a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body such that the body has metallic material. To control the degradation in a desired time window, e.g., between four weeks and six months, the following production method is performed: a) preparing the body of the implant, and b) plasma-chemical treatment of at least a portion of the surface of the body in an aqueous solution by applying a plasma-generating electric alternating voltage to the body ( | 04-08-2010 |
20100161037 | MEDICAL DEVICES COATED WITH POROUS CARBON AND METHODS OF MANUFACTURING THE SAME - A method of creating a porous carbon coating on a medical device by applying a precursor carbon material on the medical device and then pyrolysing the precursor carbon material by laser irradiation. The laser irradiation may be focused to carbonize only certain portions of the medical device and any uncarbonized areas can be removed by solvent washing. Also provided is a medical device having a carbonized coating created according to the method of the present invention. | 06-24-2010 |
20100179644 | BARRIER STENT AND USE THEREOF - The present invention relates to a vascular stent that includes an expandable stent defining an interior compartment, a first polymeric layer exposed to the interior compartment defined by the stent, the first layer comprising an agent that promotes re-endothelialization, an agent that inhibits thrombosis, or a combination thereof, and a second polymeric layer at least partially external of the stent, the second layer being adapted for contacting a vascular surface and being characterized by pores that are substantially impermeable to vascular smooth muscle cell migration. Method of making and using the vascular stent are also disclosed. | 07-15-2010 |
20100228341 | ENDOPROSTHESES - A hydrophilic ceramic coating is formed on an endoprosthesis preform. The hydrophilic ceramic coating is porous and can store nano-sized drug particles. | 09-09-2010 |
20100249913 | Reticulated elastomeric matrices, their manufacture and use in implantable devices - This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes. | 09-30-2010 |
20110009952 | IMPLANT AND METHOD FOR MANUFACTURING SAME - The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NO | 01-13-2011 |
20110022159 | POROUS MEMBRANES FOR MEDICAL IMPLANTS AND METHODS OF MANUFACTURE - The present invention involves porous polymer membranes, suitable for use in medical implants, having controlled pore sizes, pore densities and mechanical properties. Methods of manufacturing such porous membranes are described in which a continuous fiber of polymer is extruded through a reciprocating extrusion head and deposited onto a substrate in a predetermined pattern. When cured, the polymeric material forms a stable, porous membrane suitable for a variety of applications, including reducing emboli release during and after stent delivery, and providing a source for release of bioactive substances to a vessel or organ and surrounding tissue. | 01-27-2011 |
20110054595 | METHOD OF COATING MEDICAL DEVICES - Disclosed herein are medical devices, such as stents, comprising a porous substrate, such as a porous ceramic. Also disclosed herein are methods for impregnating the porous substrate with a composition comprising at least one lipid and at least one pharmaceutically active agent, where the porous substrate is microporous and/or nanoporous. | 03-03-2011 |
20110106241 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE - Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells. | 05-05-2011 |
20110218618 | Self-Regenerating Drug-Delivering Stent - A method for bulk manufacture of a microporous sheet material from polyolefin fibers, where an average pore size in the material is controlled by calendering the material through low-energy rollers at a suitable temperature, pressure and speed. The material is useful to selectively pass or reject certain substances, and may be combined in a resilient, tube-shaped configuration to form a self-regenerating drug-delivering vascular stent that reduces inflammation at the stent site to prevent restenosis. | 09-08-2011 |
20130184810 | ROTATIONAL SPUN MATERIAL COVERED MEDICAL APPLIANCES AND METHODS OF MANUFACTURE - A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis. | 07-18-2013 |
20130204355 | MEDICAL DEVICE MADE OF EPTFE PARTIALLY COATED WITH AN ANTIMICROBIAL MATERIAL - A medical device includes a porous article of expanded polytetrafluoroethylene (ePTFE) having a microstructure of nodes interconnected by fibrils, and a coating including an antimicrobial material at the surface of the porous article, wherein the microstructure at a surface of the porous article is only partially coated with the antimicrobial material. | 08-08-2013 |
20130274868 | METHODS AND DEVICES FOR TREATMENT OF VASCULAR DEFECTS - Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments include thin permeable membranes configured to occlude blood flow therethrough. | 10-17-2013 |
20140039606 | MEDICAL DEVICE - A method for treating a bifurcation or trifurcation aneurysm ( | 02-06-2014 |
20140067047 | ELECTROSPUN PTFE COATED STENT AND METHOD OF USE - A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis. | 03-06-2014 |
20140249620 | ULTRA-LOW FRACTIONAL AREA COVERAGE FLOW DIVERTER FOR TREATING ANEURYSMS AND VASCULAR DISEASES - A flow diverter is described and fabricated using ultra-thin porous thin-film Nitinol, and is configured for implantation to a treatment site within a vessel for significant reduction in an intra-aneurismal flow velocity and vorticity. Using small size pores in a coverage area of only 10%, a 90% reduction in flow velocity into a pseudo-aneurysm can be achieved, with an almost immediate cessation of flow into an anatomical feature such as aneurysm sac in vivo. The size of the holes can be tailored to be any shape and range in size from 1-400 μm using photolithography and from 5-1000 nm using ebeam lithography. | 09-04-2014 |
20140277397 | VARIABLE POROSITY INTRAVASCULAR IMPLANT AND MANUFACTURING METHOD - A vascular occlusion device for effectively occluding blood flow and pressure to a vascular defect while simultaneously not occluding blood flow and pressure to adjacent vasculature is provided. The vascular occlusion device can include a tubular member that has variable porosity regions along its length. The tubular member can be formed of a plurality of filaments that have different cross-sectional shapes along their length that are indexed to the variable porosity regions along the length of the tubular member. | 09-18-2014 |
20140288638 | MEDICAL DEVICE - The present invention relates to a medical device, particularly a vascular graft or an arteriovenous (AV) graft for haemodialysis. The medical device comprises a layer of porous silk fibroin matrix and a layer of knitted silk fibres. The invention further relates to processes of manufacture of such medical devices and methods of use of such devices. | 09-25-2014 |
20150313736 | METHODS AND APPARATUS FOR LUMINAL STENTING - Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow. | 11-05-2015 |
623100400 | Pore gradient | 6 |
20080249599 | Stent With Therapeutic Agent Delivery Structures in Low Strain Regions - A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of therapeutic agent-carrying regions and non therapeutic agent-carrying regions. The therapeutic agent-carrying regions are located within low strain regions of the stent and the non therapeutic agent-carrying regions are located within high strain regions of the stent. Another embodiment of the invention includes a method of manufacturing a therapeutic agent-carrying stent comprising forming a stent framework and applying a formulation containing one or more therapeutic agents to the stent framework while preventing the therapeutic agents from contacting the high strain regions of the stent framework. | 10-09-2008 |
20080249600 | STENTS WITH DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME - A method of making drug eluting stents comprises forming ceramic surface coatings of two or more levels of porosity on a stent body. The less porous coating is more conducive to endothelial cell growth, while the more porous coating is better suited for storing and releasing drugs. The surface coatings of different porosities can be produced by coating stent body surface of differing roughness with coatings made by sol-gel method. Differing roughness of the stent body surface can be produced by selective etching of the stent body surface. | 10-09-2008 |
20090118809 | ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER - An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g. directly in the body of the stent, and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir | 05-07-2009 |
20120310319 | Stent - In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer. | 12-06-2012 |
20130172975 | METHODS AND APPARATUS FOR LUMINAL STENTING - Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow. | 07-04-2013 |
20130304178 | IMPLANT AND METHOD FOR MANUFACTURING SAME - The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. For controlling the degradation of the implant the method includes the following steps: (a) providing a first part of the implant body; and (b) performing heat treatment which alters the carbon content and/or the boron content and/or the nitrogen content in the structure of a near-surface boundary layer in the first part of the implant body in such a way that strain on the lattice or a lattice transformation, optionally following a subsequent mechanical load, is achieved in the near-surface boundary layer. Such an implant is also described. | 11-14-2013 |