| Entries |
| Document | Title | Date |
|---|
| 20080208174 | Device for the Controlled Release of a Predefined Quantity of a Substance - The application provides a device ( | 08-28-2008 |
| 20080221557 | METHOD OF OPENING RESERVOIR OF CONTAINMENT DEVICE - A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to said reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor. | 09-11-2008 |
| 20080249511 | In Situ Blood Vessel and Aneurysm Treatment - Treatment of aneurysmal blood vessels with local delivery of therapeutic agents thereby reduces or lessens the severity of an aneurysm, and, where used in conjunction with the placement of an excluding device, provides for more rapid recovery of the blood vessel from any disturbance occurring during placement of the excluding device. Therapeutic agents are placed in the aneurysmal site in a time-release carrier medium, such that the therapeutic agent is released into the aneurysmal site over a period of time without the need to provide systemic introduction of the therapeutic agent. The carrier may be introduced through the patient's dermis, such as with the use of a laparoscope, or intravascularly, through the use of a catheter. The carrier may be in a solid matrix, viscous liquid or liquid form. | 10-09-2008 |
| 20080255543 | BODY-INSERTABLE APPARATUS AND MEDICAL AGENT DISCHARGE METHOD - A body-insertable apparatus according to an aspect of the present invention is introduced into a subject to inject medical agent stored in a casing into a desired part in the subject. The body-insertable apparatus includes a fixing unit which fixes the casing to the desired part; and a projecting unit which projects, from the casing, an injection needle for injecting the medical agent. The fixing unit and the projecting unit are driven by a driving source. | 10-16-2008 |
| 20080269724 | Implantable drug delivery device with programmable rate capacitor charge control - An implantable drug delivery device includes a pump motor that is asserted by drive currents from a storage capacitor. A programmable rate charge control delivers charging current from a battery to the storage capacitor based upon a programmable charge rate value, a minimum battery voltage value, sensed charging current, and sensed battery voltage. When sensed battery voltage droops to below a threshold value, the charge control reduces the charging rate value until other electrical loads within the drug device have been serviced and battery voltage is restored. The charge control also monitors capacitor voltage and provides a charge complete signal to a motor control, which then connects the pump motor to the storage capacitor to produce a pump stroke. Efficiency of charging is enhanced by controlling the charging at a programmable substantially constant rate. | 10-30-2008 |
| 20080281298 | Electronic support system for biological data sensor - An electronic support system for controlling a biological data sensor and related methods of use are disclosed herein. | 11-13-2008 |
| 20080294148 | SYSTEM AND METHOD FOR REFILLING AN IMPLANTED DELIVERY DEVICE - An apparatus for refilling an implanted delivery device has a needle connected to an output port of a three-way valve. One input port is sealed and the other is connected to a fluid source. When the valve is in a fluid delivery position, fluid from the fluid source flows through the needle, and when the valve is in a stylet insertion position, fluid from the fluid source is prevented from flowing through the needle. When the valve is in the stylet insertion position, a stylet can be inserted through the second input port and into the lumen of the needle, thereby occluding the needle's lumen. In this configuration, a practitioner inserts the needle with stylet therein into the body of the patient to engage the devices's refill port. The stylet is removed, the fluid delivery path is opened, and medication is delivered to the device's reservoir without being contaminated with tissue. | 11-27-2008 |
| 20080319425 | DRUG-ELUTING GRAFT - Embodiments of the present invention provide a device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first element capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. In embodiments, the first element may be fully or partially microporous or a separate intermediate microporous membrane may be provided. Also provided are methods of mixing or moving a drug within a reservoir using various mixing elements. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing a device in accordance with embodiments of the present invention. | 12-25-2008 |
| 20090005763 | Implantable Devices and Methods for Delivering Drugs and Other Substances to Treat Sinusitis and Other Disorders - Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body. | 01-01-2009 |
| 20090012503 | Body-Insertable Apparatus - A body-insertable apparatus is introduced in a subject to perform at least one of input and output of a predetermined fluid to and from the subject. The body-insertable apparatus includes a reservoir ( | 01-08-2009 |
| 20090012504 | CLOSED LOOP MEDICAMENT PUMP - A device to determine the level of a substance of interest in a patient's body and provide a therapeutic amount of medicament is disclosed. The level of a substance of interest in the patient's body is determined by iontopheretically sampling the patients' blood and then analyzing the resulting sample to determine the level of the substance of interest. The information about the level of a substance of interest is transmitted to an implanted drug pump in the patient's body. The preferred method of transmitting information about the level of a substance of interest determined by the sensor is transmitted to an implanted drug pump in the patient's body is via a so called “body bus”. The “body bus” is a telemetry system where the patient's own body provides the interconnection between the iontopheretic device and the implanted drug pump. | 01-08-2009 |
| 20090030404 | CONTAINMENT DEVICE WITH MULTI-LAYER RESERVOIR CAP STRUCTURE - Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps. | 01-29-2009 |
| 20090043289 | DRUG TITRATION UTILIZING AN IMPLANTABLE MEDICAL DEVICE - A method for titrating a drug to provide a medical therapy to a patient. The method includes the steps of providing an implantable medical device having a controller, providing one or more implantable sensors configured to sense physical parameters of the patient and configured to transmit signals to the controller. The method further includes the step of receiving signals from the one or more sensors at the controller. The method additionally includes processing the received signals to determine at least two cardiopulmonary characteristics of the patient. The method also includes determining a composite index based on the at least two cardiopulmonary characteristics. In addition, the method includes generating a signal based on the composite index. Medical device systems are also disclosed. | 02-12-2009 |
| 20090043290 | Drug Delivery Safety System - A drug delivery safety system includes a programmer with a display and a communications device adapted to communicate with an ambulatory medical device. The programmer has access to a database of information, and is adapted to receive and process the information and a user input and to control the display to provide a graphical user interface that prompts a user of the programmer to provide an additional user input when the user input requests a drug delivery protocol for the ambulatory medical device that is not already stored in the database as a clinician-approved drug delivery protocol. | 02-12-2009 |
| 20090043291 | Closed Loop Medicament Pump - A device to determine the level of a substance of interest in a patient's body and provide a therapeutic amount of medicament is disclosed. The level of a substance of interest in the patient's body is determined by iontopheretically sampling the patient's blood and then analyzing the resulting sample to determine the level of the substance of interest. The information about the level of a substance of interest is transmitted to an implanted drug pump in the patient's body. In the preferred embodiment, the substance of interest sensor is an external sensor applied to the user's skin. In an alternate embodiment, the sensor may be implanted. The preferred method of transmitting information about the level of a substance of interest determined by the sensor is transmitted to an implanted drug pump in the patient's body is via a so called “body bus”. The “body bus” is a telemetry system where the patient's own body provides the interconnection between the iontopheretic device and the implanted drug pump. | 02-12-2009 |
| 20090048584 | Closed Loop Medicament Pump - A device to determine the level of a substance of interest in a patient's body and provide a therapeutic amount of medicament is disclosed. The level of a substance of interest in the patient's body is determined by iontopheretically sampling the patient's blood and then analyzing the resulting sample to determine the level of the substance of interest. The information about the level of a substance of interest is transmitted to an implanted drug pump in the patient's body. In the preferred embodiment, the substance of interest sensor is an external sensor applied to the user's skin. In an alternate embodiment, the sensor may be implanted. The preferred method of transmitting information about the level of a substance of interest determined by the sensor is transmitted to an implanted drug pump in the patient's body is via a so called “body bus”. The “body bus” is a telemetry system where the patient's own body provides the interconnection between the iontopheretic device and the implanted drug pump. | 02-19-2009 |
| 20090082757 | PRESSURE BASED REFILL STATUS MONITOR FOR IMPLANTABLE PUMPS - The present invention includes systems and methods for detecting fluid flow into or out of a port chamber or a reservoir of an implantable medical device utilizing a pressure sensor. The system detects characteristic pressure profiles associated with fluid flowing into the medical device, out of the medical device, and also whether one or both of the port chamber or reservoir are substantially empty or substantially full. In addition, the present invention may generate a sensory cue to a clinician to indicate the fluid status. | 03-26-2009 |
| 20090082758 | Implantable Fluid Distribution Device and Method of Fluid Delivery - An implantable fluid distribution device is described. The device includes a first inlet for receiving fluid under pressure from a remote pump. A plurality of outlets are also provided, each outlet being connectable to a fluid delivery catheter. A valve mechanism is arranged to control the passage of fluid from the first inlet to the plurality of outlets. Apparatus including the fluid distribution device, an implantable pump and a plurality of drug delivery catheters is also described. The fluid distribution device can be used to delivery drug to multiple regions in the body and the sequential delivery of drugs to different sites in the brain is disclosed. | 03-26-2009 |
| 20090088732 | Rapid Refill Programming for Implantable Drug Pump - A programming device for an implantable drug pump includes a display device, a communication device, and a controller. The communication device is adapted to facilitate a communication link between the programming device and an implantable drug pump. The controller is adapted to receive identification information for the implantable drug pump when the communications link has been established and, when the implantable drug pump has been identified, to control the display device to generate a graphical user interface which permits a user of the programming device to initiate a refill procedure for the implantable drug pump. | 04-02-2009 |
| 20090093797 | Two way accumulatorprogrammable valve pump - An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration. | 04-09-2009 |
| 20090099553 | DEVICE FOR THE CONTROLLED RELEASE OF A SUBSTANCE AND METHOD OF RELEASING A SUBSTANCE - This invention provides a device for the controlled release of a substance and a method of controllably releasing a substance from a compartment. The device comprises a plurality of compartments in a substrate, each compartment being closed by at least one release mechanism, wherein the release | 04-16-2009 |
| 20090105694 | Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more. | 04-23-2009 |
| 20090112189 | Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more. | 04-30-2009 |
| 20090112190 | Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules comprising a first module operable in a digestive or respiratory tract to engage a second module, optionally by a magnetic field. Alternatively or additionally, systems may be operable to remain in situ and also operable to permit a therapeutic material dispensation. In some contexts, for example, systems or methods may dispense a therapeutic material via a subject's throat or elsewhere in the digestive or respiratory tract. | 04-30-2009 |
| 20090112191 | Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules comprising a first module operable in a digestive or respiratory tract to engage a second module, optionally by a magnetic field. Alternatively or additionally, systems may be operable to remain in situ and also operable to permit a therapeutic material dispensation. In some contexts, for example, systems or methods may dispense a therapeutic material via a subject's throat or elsewhere in the digestive or respiratory tract. | 04-30-2009 |
| 20090118711 | REDUCED-NOISE IMPLANTABLE INFUSION DEVICE - A drive mechanism for delivery of infusion medium in an implantable medical device includes an inlet for receiving the infusion medium and a piston channel for communication of infusion medium received by the inlet. The piston channel has a distal end and a proximal end. The proximal end is closer to the inlet than the distal end. The drive mechanism further includes a coil surrounding the piston channel and a piston located within the piston channel and moveable axially within the piston channel to drive infusion medium out of the distal end of the piston channel. The mechanism also includes an armature operably coupled to the piston and disposed adjacent the coil. The armature has first and second opposing major surfaces and a plurality of vents extending through the armature from the first major surface to the second major surface. The plurality of vents cumulatively occupy between about 20% and about 40% of the total surface area of the first major surface. Electromagnetic interaction between the armature and the coil cause the piston move in the channel. | 05-07-2009 |
| 20090131919 | Implantable medical device - The present invention comprises a modular, implantable medical device comprising a body portion capable of receiving a treatment device that accesses a patient's inner physiology while communicating with a device external to the patient. The body portion further includes a first skirt and a second skirt that surround the treatment device at its junction with the body portion. Both skirts are designed to gradually affix themselves into the surrounding tissues of the patient's body during an initial phase of healing. The first skirt is designed to separate from the device at a lower force than the second skirt such that during removal, the device and second skirt can be detached as a unit from patient's skin and first skirt without excessive force or trauma and the first skirt remains attached to the patient's skin as a permanent implant. | 05-21-2009 |
| 20090157054 | Treatment indications informed by a priori implant information - Systems and methods are described for implementing or deploying therapeutic administration systems for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment partly based on the a priori implant information and partly based on one or more other clot-indicative determinants; or obtaining a flow-change-indicative measurement and signaling a decision whether to administer one or more clot-reducing agents at least partly based on the flow-change-indicative measurement; or obtaining one or more indications of a lytic material in a vicinity of one or more body lumens and accelerating a decrease in a local concentration of the lytic material in the vicinity of the one or more body lumens by causing one or more elements to extract at least a portion of the lytic material in the vicinity of the one or more body lumens in response to the one or more indications of the lytic material in the vicinity of the one or more body lumens; or one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature. | 06-18-2009 |
| 20090157055 | Treatment indications informed by a priori implant information - Systems and methods are described for implementing or deploying therapeutic administration systems for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment partly based on the a priori implant information and partly based on one or more other clot-indicative determinants: or obtaining a flow-change-indicative measurement and signaling a decision whether to administer one or more clot-reducing agents at least partly based on the flow-change-indicative measurement; or obtaining one or more indications of a lactic material in a vicinity of one or more body lumens and accelerating a decrease in a local concentration of the lytic material in the vicinity of the one or more body lumens by causing one or more elements to extract at least a portion of the lytic material in the vicinity of the one or more body lumens in response to the one or more indications of the lytic material in the vicinity of the one or more body lumens; or one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature. | 06-18-2009 |
| 20090157056 | Circulatory monitoring systems and methods - Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects. Some involve implementing or deploying therapeutic administration systems, for example, for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment partly based on the a priori implant information and partly based on one or more other clot-indicative determinants; or obtaining a flow-change-indicative measurement and signaling a decision whether to administer one or more clot-reducing agents at least partly based on the flow-change-indicative measurement; or obtaining one or more indications of a lytic material in a vicinity of one or more body lumens and accelerating a decrease in a local concentration of the lytic material in the vicinity of the one or more body lumens by causing one or more elements to extract at least a portion of the lytic material in the vicinity of the one or more body lumens in response to the one or more indications of the lytic material in the vicinity of the one or more body lumens; or one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature. | 06-18-2009 |
| 20090157057 | Circulatory monitoring systems and methods - Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects. Some involve implementing or deploying therapeutic administration systems, for example, for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment partly based on the a priori implant information and partly based on one or more other clot-indicative determinants; or obtaining a flow-change-indicative measurement and signaling a decision whether to administer one or more clot-reducing agents at least partly based on the flow-change-indicative measurement; or obtaining one or more indications of a lytic material in a vicinity of one or more body lumens and accelerating a decrease in a local concentration of the lytic material in the vicinity of the one or more body lumens by causing one or more elements to extract at least a portion of the lytic material in the vicinity of the one or more body lumens in response to the one or more indications of the lytic material in the vicinity of the one or more body lumens; or one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature. | 06-18-2009 |
| 20090157058 | Circulatory monitoring systems and methods - Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects. Some involve implementing or deploying therapeutic administration systems, for example, for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment partly based on the a priori implant information and partly based on one or more other clot-indicative determinants; or obtaining a flow-change-indicative measurement and signaling a decision whether to administer one or more clot-reducing agents at least partly based on the flow-change-indicative measurement; or obtaining one or more indications of a lytic material in a vicinity of one or more body lumens and accelerating a decrease in a local concentration of the lytic material in the vicinity of the one or more body lumens by causing one or more elements to extract at least a portion of the lytic material in the vicinity of the one or more body lumens in response to the one or more indications of the lytic material in the vicinity of the one or more body lumens; or one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature. | 06-18-2009 |
| 20090187167 | INTEGRATED INTRA-DERMAL DELIVERY, DIAGNOSTIC AND COMMUNICATION SYSTEM - In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system. | 07-23-2009 |
| 20090209945 | VALVELESS IMPEDANCE PUMP DRUG DELIVERY SYSTEMS - A drug-delivery unit suitable for implantation into a patient body may include a valveless impedance pump. In some implementations the unit may include an actuator, control electronics and a battery, and may communicate with an external patient interface unit. The patient interface unit can be used to control operation of the implant and to download data from the implant. The patient interface unit can also be used to charge the implant and/or a separate charger can be used. In other implementations, a drug-delivery implant unit may lack internal electronics and instead rely on an externally-supplied magnetic field to actuate the pump. | 08-20-2009 |
| 20090234331 | ELECTRONICALLY CONTROLLED PILL AND SYSTEM HAVING AT LEAST ONE SENSOR FOR DELIVERING AT LEAST ONE MEDICAMENT - An electronically controlled pill ( | 09-17-2009 |
| 20090240241 | Subdermal material delivery device - A method may include placing a first device on a first side of a skin portion of a subject and transferring a material through the skin portion of the subject from the first device to a subdermal second device disposed on a second side of the skin portion of the subject. | 09-24-2009 |
| 20090259215 | Methods and systems associated with delivery of one or more agents to an individual - The present disclosure relates to methods and systems for administration of one or more agents. | 10-15-2009 |
| 20090259216 | AUTOMATED INTEGRITY TESTS - Techniques for testing integrity of various elements of implantable medical device systems are described. Some embodiments automatically test the integrity of one or more system elements in response to detecting an event. Examples of events in response to which an integrity test may be performed include the patient being within a target activity state, a symptomatic event experienced by a patient, an external impact on the patient that exceeds a damage threshold, or an indication that the patient is receiving inappropriate therapy. Some embodiments automatically test integrity in response to failure to autonomously detect an event, which may be indicated by input from a patient. An implantable lead carrying electrodes or a therapeutic substance delivery element, such as a catheter, are examples of system elements for which integrity may be tested in some embodiments. | 10-15-2009 |
| 20090259217 | Methods and systems associated with delivery of one or more agents to an individual - The present disclosure relates to methods and systems for administration of one or more agents. | 10-15-2009 |
| 20090264870 | IMPLANTABLE INFUSION DEVICE HAVING FILTER - An implantable infusion device for delivering a fluid medication to a patient. The infusion device has an internal bacterial filter positioned between the reservoir and the pump, configured to provide a pathway for fluid to be pulled from the reservoir to the pump, regardless of the orientation of the infusion device. The configuration of the filter provides a fluid pathway from the reservoir to the pump, even in the presence of a gas bubble. | 10-22-2009 |
| 20090270844 | FLOW SENSOR CONTROLLED INFUSION DEVICE - An implantable infusion device includes an outlet through which a fluid is deliverable and a reservoir for containing the fluid. A flow path is in fluid communication with the reservoir and the outlet. The flow path includes a pressure regulator and a flow restrictor. The pressure regulator has a housing defining a major chamber and a diaphragm disposed in the housing such that the diaphragm sealingly divides the major chamber into first and second minor chambers. The flow restrictor is in fluid communication with the first and second minor chambers of the pressure regulator and is disposed downstream of the first minor chamber and upstream of the second minor chamber. The device further includes (i) a flow sensor configured to detect information regarding flow rate of the fluid downstream of the flow restrictor, and (ii) a pressure adjustment actuator assembly configured to vary pressure in the first minor chamber of the pressure regulator relative to pressure in the second minor chamber. The device also includes a processor operably coupled to the flow sensor and the pressure adjustment actuator assembly. The processor is configured to provide instructions to the actuator assembly for adjusting the pressure in the first minor chamber relative to pressure in the second minor chamber based on the information from the sensor to regulate flow rate of the fluid. | 10-29-2009 |
| 20090275924 | Systems and Methods for Monitoring and Controlling Internal Pressure of an Eye or Body Part - Systems and methods for automatically monitoring and controlling pressure in a body part are disclosed. The systems include an implantable tube with one open end of the tube implanted in the body part, an implantable valve coupled with the tube having at least one open state and a closed state, an implantable sensor for measuring pressure, and an implantable control device coupled with the sensor and the valve. The control device switches the valve between the at least one open state and the closed state, based on pressure information received from the sensor. When the valve is in the at least one open state, the tube drains fluids from the body part due to a difference of pressure between the open ends of the tube. Methods for using the systems to administer drugs and monitor and control fluid pressures in various biological systems are also disclosed. | 11-05-2009 |
| 20090275925 | DEVICE FOR THE CONTROLLED RELEASE OF A SUBSTANCE - An implantable drug delivery system is proposed which does not need internal electronics, but can be activated from outside the body. The system comprises a device ( | 11-05-2009 |
| 20090287191 | Circulatory monitoring systems and methods - Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects. | 11-19-2009 |
| 20090306633 | ELECTRONICALLY CONTROLLED CAPSULE - An electronically controlled capsule or medicament delivery system ( | 12-10-2009 |
| 20090318902 | Magnetic Breather Pump and a Method for Treating a Brain Tumor Using the Same - A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. | 12-24-2009 |
| 20090318903 | Magnetic Breather Pump and a Method for Treating a Brain Tumor Using the Same - A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. | 12-24-2009 |
| 20090326517 | FLUIDIC CAPILLARY CHIP FOR REGULATING DRUG FLOW RATES OF INFUSION PUMPS - An erosion-resistant capillary chip for use with in an infusion pump that is made from a silicon substrate having a first surface that includes a micro groove etched therein and a glass plate laminated to the first surface. The glass plate covers the micro groove so that a micro fluid conduit is created. The glass plate includes an inlet bore that connects with the micro fluid conduit and the silicon substrate includes an outlet bore that connects with the micro fluid conduit so that a drug solution entering the inlet bore from the infusion pump may pass through the micro fluid conduit at a restricted flow rate to the outlet bore and thereafter to a target site of a patient. The micro groove includes a passivation layer made from silicon nitride or silicon carbide that protects the micro groove against erosion from passing fluids having high basic or high acidic pH levels. A method for making the capillary chip is disclosed, as well as an infusion pump incorporating the improved capillary chip. | 12-31-2009 |
| 20100004637 | System and method for implantation of devices having unknown biocompatible materials - There is disclosed a system and method for allowing use within a body of devices having material not known for its biocompatibility with the body. In one embodiment, a magnetically controlled solenoid/valve is used where portions of the valve are directly in contact with compositions that are to be delivered to a target site. Advantage is taken of an existing solenoid/valve having chromium alloy parts by coating the portions of the valve that contact the deliverable composition with a known biocompatible material having good wear resistance. In one embodiment, titanium nitride (TiN) is used as the coating material. | 01-07-2010 |
| 20100004638 | Implantable Infusion Devices With Overfill Protection - Implantable medical devices that prevent over fill. | 01-07-2010 |
| 20100004639 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon. | 01-07-2010 |
| 20100010479 | DOSAGE CONTROL APPARATUS - The invention is directed to a dose control apparatus. The apparatus has two armatures pressed against a valve seat by at least one spring. A coil induces a magnetic field that motivates the armatures against the force of the spring, thereby opening the valve. The armatures may move along a common axis in opposite directions. The apparatus may also include a core located between the armatures and a casing about the coil. The core and casing act to guide the magnetic field, reducing the power requirements for creating the field. Current may be periodically reversed in the coil to provide a degaussing field. In addition, a signal may be produced by the coil in the presence an externally applied magnetic field such as an MRI. An opposing magnetic field may be produced by the coil or the current provided to the coil may be adjusted. | 01-14-2010 |
| 20100022991 | System and device for maintaining physiological levels of steroid hormone in a subject - A system, device, or method is provided which maintains a substantially physiological level or a substantially physiological cyclic pre-menopausal level of one or more steroid hormones in a mammalian subject in need thereof. The system, device, or method includes providing to the subject at least one treatment regimen including replacement therapy for the one or more steroid hormones or metabolites or modulators thereof, wherein the at least one treatment regimen is determined based on pre-menopausal cyclic steroid hormone levels of the subject and on current cyclic steroid hormone levels of the subject, wherein the at least one treatment regimen is configured to maintain the subject's one or more steroid hormones or metabolites or modulators thereof at substantially physiological cyclic pre-menopausal levels. The system, device, or methods can be used for the treatment of a disease or condition in the mammalian subject. | 01-28-2010 |
| 20100022992 | Drug Delivery Device - The present application provides a drug-delivery device comprising a drug reservoir chamber | 01-28-2010 |
| 20100069891 | Implantable Pump With Integrated Refill Detection - A refill port for an implantable device with integral refill instrument placement detection includes a pierceable septum and a detector. The pierceable septum is disposed on the refill port for admitting a refill instrument has a first outer surface at least a portion of which is exposed outside the refill port and a second inner surface at least a portion of which is exposed inside the refill port. The detector is disposed inside the refill port with respect to the second inner surface of the pierceable septum for determining the placement of a refill instrument within the refill port. The refill port can be provided on a refillable implantable drug delivery pump having control electronics so that the detector can trigger pump test features of the control electronics upon placement or removal of a refill instrument from the port. | 03-18-2010 |
| 20100069892 | VARIABLE FLOW INFUSION PUMP SYSTEM - An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump and a removable module. The module may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the flow rate, electronics for analyzing the flow rate information, and a mechanism for physically altering the flow rate. Methods of dispensing a medicament to a patient are also disclosed, as are variations of the pump system. | 03-18-2010 |
| 20100076413 | DIAPHRAGM DRUG PUMP - Embodiments of the invention provide apparatus, systems and methods for delivering drugs using an implantable diaphragm based drug pump which can deliver precisely controlled doses of drug to selected target tissue sites in the brain, digestive system, blood stream heart or other selected site. Various embodiments of the pump include multi-chamber bellows or other diaphragm based pumps which can rapidly deliver drug to the selected target tissue site. | 03-25-2010 |
| 20100076414 | Remote control of substance delivery system - Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used. | 03-25-2010 |
| 20100076415 | Remote control of substance delivery system - Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used. | 03-25-2010 |
| 20100100079 | IMPLANTABLE DEVICE SYSTEM - An implantable device system is disclosed. The implantable device system includes, a first energy transceiver system, a second energy transceiver system at least partially implanted within an organic tissue and capable of communication with the first energy transceiver system, and a sensing system capable of communication with the second energy transceiver system. An implantable device system array is also disclosed. A method of monitoring a physical parameter is also disclosed. | 04-22-2010 |
| 20100114074 | Sustained delivery of an active agent using an implantable system - The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved. | 05-06-2010 |
| 20100137843 | Delivery devices for modulating inflammation - Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes. | 06-03-2010 |
| 20100137844 | Delivery devices for modulating inflammation - Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes. | 06-03-2010 |
| 20100145317 | DEVICE SYSTEM AND METHOD FOR MONITORING AND CONTROLLING BLOOD ANALYTE LEVELS - A device and system for monitoring an analyte in a subject and for controlling blood analyte levels are provided. The device and system include a sensor element which is designed and configured for detecting the analyte in blood flowing through the bone of the subject. | 06-10-2010 |
| 20100145318 | Method and Device for Changing the pH of a Solution - The invention relates to a device ( | 06-10-2010 |
| 20100152713 | IMPLANTABLE DRUG DELIVERY SYSTEM HAVING PERIODIC DRUG DELIVERY REGIMEN TO AVOID GRANULOMAS - An implantable drug delivery system including: a biocompatible or bio-inert housing containing a drug infusion pump, a drug chamber from which a liquid drug is dispensed when the pump applies a force to the drug chamber, and an internal controller actuating the pump; a delivery catheter extending from the housing to one or more drug delivery treatment sites in a target tissue, wherein the catheter includes a lumen having an inlet to receive a drug pumped from the drug chamber and an outlet are positioned at the target tissue, wherein the drug flows through the outlet to the target tissue, and wherein the internal controller stores and executes an automatic periodic flow regimen which commands the pump and drug chamber to periodically dispense an intermittent bolus or pulse of the liquid drug, wherein the periodic flow regimen provides a prophylactic treatment for granuloma. | 06-17-2010 |
| 20100152714 | AIR TOLERANT IMPLANTABLE PISTON PUMP - An implantable infusion device includes a reservoir for housing an infusion medium and a drive mechanism having an inlet chamber, a piston and a piston channel. The inlet chamber is in fluid communication with the reservoir. The piston channel is in fluid communication with the inlet chamber, and has a distal end and a proximal end, the proximal end being closer to the inlet channel than the distal end. The piston is axially moveable within the piston channel to drive infusion medium out of the distal end of the piston channel. The clearance between the piston and the channel is sufficiently small to prevent undissolved gas in the inlet chamber from passing through the clearance. The inlet chamber may be sufficiently large to allow undissolved gas to accumulate without adversely affecting the performance of the infusion device. | 06-17-2010 |
| 20100160902 | INFUSION DEVICE WITH IMPEDANCE MEASUREMENT CROSS-REFERENCE TO RELATED APPLICATIONS - An ambulatory infusion device for the infusion of a liquid drug into a patient's body over an extended time period includes an infusion cannula designed to be placed in the patient's subcutaneous tissue. At least two subcutaneous electrodes are comprised by the infusion cannula and are placed in the subcutaneous tissue. An impedance measuring unit is operatively coupled to the at least two electrodes and is configured to measure at least one impedance value between the at least two electrodes. A variation of the at least one impedance value reflects a displacement of interstitial fluid by drug upon drug administration. An event trigger unit is operatively coupled to the impedance measuring unit and being configured to evaluate the at least one impedance value and to generate an event trigger if evaluation of the at least one impedance value indicates the occurrence of an administration anomaly. | 06-24-2010 |
| 20100174272 | IN-SITU REFILLABLE OPHTHALMIC IMPLANT - The present invention is directed to an in-situ refillable ophthalmic implant having a refill port in communication with a reservoir and a release control mechanism. The present invention also relates to methods of forming and using the ophthalmic implant. Preferably, the control release mechanism include opening[s] providing for passive passage of pharmaceutical ophthalmic composition, particularly therapeutic agent, out of the reservoir, through the opening[s] and into the eye. | 07-08-2010 |
| 20100179518 | Microelectrode-Equipped Subdural Therapeutic Agent Delivery Strip - An apparatus for treating the brain, comprises a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the brain, the first fluid delivery device including a first fluid lumen extending to a first outlet port in the distal end to deliver fluids to a first target location and a first microelectrode mounted within the distal end of the first fluid delivery device for movement between an insertion position in which a first distal tip of the first microelectrode is received within the first fluid delivery device and a deployed position in which the first microelectrode extends out of the first fluid delivery device with the first distal tip thereof penetrating the pia mater to a first electrode target position in the cerebral cortex. | 07-15-2010 |
| 20100185181 | DISPLAY OF SUPPLEMENTAL BOLUS IN RELATION TO PROGRAMMED DOSE - Techniques are described for displaying a representation of a supplemental bolus and a representation of programmed doses of a therapy schedule for an implantable fluid delivery device with a programmer device. In one example, a device includes a user interface to present a graphical representation of doses of fluid to be delivered to a patient via an implantable fluid delivery device and a processor that controls the user interface to simultaneously present a first graphical representation of a supplemental bolus to be delivered by the implantable fluid delivery device and a second graphical representation of programmed doses of a therapy schedule of the implantable fluid delivery device, wherein at least a portion of the programmed doses of the therapy schedule follows delivery of the supplemental bolus by the implantable fluid delivery device. A user of the device may determine whether the representations indicate an excessive dosage risk to the patient. | 07-22-2010 |
| 20100185182 | USER INTERFACE INDICATING FLUID LOCATION FOR AN IMPLANTABLE FLUID DELIVERY DEVICE - A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that displays a representation of a portion of the implantable fluid delivery device and displays an indication of a location of fluid within the implantable fluid delivery device during a delivery phase, e.g., a priming or bridging phase. The user interface may display a representation of progress of the delivery phase. The user interface may display the indication of the location of the fluid within internal tubing of the implantable fluid delivery device or within a catheter of the implantable fluid delivery device. The programmer device may display the representation of the progress of the delivery phase as a simulation of the delivery phase or during the actual delivery phase of the implantable fluid delivery device. A user may therefore observe a location of fluid corresponding to progress of the delivery phase. | 07-22-2010 |
| 20100185183 | USER INTERFACE THAT DISPLAYS PENDING AND SELECTED PROGRAMMING FOR AN IMPLANTABLE MEDICAL DEVICE - Techniques are described for simultaneously displaying representations, such as graphical representations, of both a selected dosing program of an implantable fluid delivery device and a pending dosing program of the implantable fluid delivery device. In one example, a system includes an implantable fluid delivery device that delivers fluid to a patient according to a selected dosing program, and a programmer device that includes a user interface comprising a display to present a graphical representation of doses of fluid to be delivered to a patient via an implantable fluid delivery device, and a processor that controls the user interface to simultaneously present on the display a first indication of a selected dosing program of the implantable fluid delivery device and a second indication of a pending dosing program of the implantable fluid delivery pump. A user may therefore compare the selected dosing program with the pending dosing program. | 07-22-2010 |
| 20100204683 | THERAPEUTIC HYBRID IMPLANTABLE DEVICES | 08-12-2010 |
| 20100217239 | PARTIALLY IMPLANTABLE MEDICAL DEVICES AND METHODS - Partially implantable medical devices and methods associated with partially implantable medical devices. | 08-26-2010 |
| 20100217240 | PARTIALLY IMPLANTABLE MEDICAL DEVICES WITH CARTRIDGE MOVEMENT SENSOR AND ASSOCIATED METHODS - Partially implantable medical devices and methods associated with partially implantable medical devices. | 08-26-2010 |
| 20100217241 | FLUID CARTRIDGES AND PARTIALLY IMPLANTABLE MEDICAL DEVICES FOR USE WITH SAME - Partially implantable medical devices and methods associated with partially implantable medical devices. | 08-26-2010 |
| 20100217242 | PARTIALLY IMPLANTABLE MEDICAL DEVICES AND DELIVERY/MANIFOLD TUBE FOR USE WITH SAME - Partially implantable medical devices and methods associated with partially implantable medical devices. | 08-26-2010 |
| 20100217243 | PARTIALLY IMPLANTABLE MEDICAL DEVICES AND TREATMENT METHODS ASSOCIATED WITH SAME - Partially implantable medical devices and methods associated with partially implantable medical devices. | 08-26-2010 |
| 20100217244 | FLUID CARTRIDGES INCLUDING A POWER SOURCE AND PARTIALLY IMPLANTABLE MEDICAL DEVICES FOR USE WITH SAME - Partially implantable medical devices and methods associated with partially implantable medical devices. | 08-26-2010 |
| 20100222769 | MEMS ELECTROCHEMICAL BELLOWS ACTUATOR - An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, to dispense that fluid under the control of an actuator, and to be implanted within the body of a living host. An actuator within the fluid reservoir may cause the fluid to be controllably dispensed from the fluid reservoir. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand. Methods of making the bellows which utilize stacked sheets are also disclosed. | 09-02-2010 |
| 20100222770 | FLUID DELIVERY DEVICE WITH A DIFFUSION MEMBRANE FOR FAST RESPONSE TIME - A fluid delivery device can be used to deliver fluid within a living body. The fluid delivery device includes an electrochemical pump, a reservoir, a displaceable member, and a diffuse membrane. The electrochemical pump transports water and includes an electrochemical pump product chamber to retain water transported by the electrochemical pump. The reservoir contains a fluid to be delivered. The displaceable member is positioned between the electrochemical pump product chamber and the reservoir. The displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber. The diffuse membrane generates increased pressure within the electrochemical pump product chamber. | 09-02-2010 |
| 20100228234 | Device for actively removing a target cell from blood or lymph of a vertebrate subject - Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate a physiological effect of the one or more target cell types in the vertebrate subject; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen; wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor. | 09-09-2010 |
| 20100268199 | Device for passively removing a target component from blood or lymph of a vertebrate subject - Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components. | 10-21-2010 |
| 20100268200 | FLUID METERING DEVICE - A device for metering fluids comprising a fluid chamber with one inlet or outlet port, at least one sidewall and a movable separator that is in contact with and separates the fluid in the chamber from the other components of the device, a porous actuator housing and wicking material, a flexible polymer actuator material in contact with the porous actuator housing and the moveable separator, an actuator hydrating solution reservoir with at least one sidewall, an inlet port, and in fluid contact with porous actuator housing, a fluid gate located at some point between actuator hydrating solution reservoir and the polymer actuator, effectively keeping actuator dry, and an external shell to hold all components so that the polymer actuator can only move in a direction and apply pressure to the separator in contact with the fluid in the fluid chamber, thereby dispensing fluid from fluid chamber. | 10-21-2010 |
| 20100280500 | MEDICAL DEVICE THERAPY BASED ON POSTURE AND TIMING - This disclosure describes techniques implemented by a medical device, such as an implantable medical device (IMD). The IMD may be configured to detect a posture state of a patient, and deliver posture-responsive therapy. In particular, the IMD not only detects the posture state of a patient, but also detects timing associated with the detected posture state, such as the time of day, the day of the week, or a specific time of day associated with a specific day. In this way, the posture-responsive therapy delivered by the IMD may be dependent not only on the posture state of the patient, but also on the timing associated with the posture state. The same posture state, therefore, may result in different types of therapy to the patient if the same posture occurs at different times of the day. | 11-04-2010 |
| 20100280501 | MODULAR MEDICAL PUMP ASSEMBLY - A medical pump subassembly comprises a magnetic cup forming a recess. The magnetic cup includes a protrusion within the recess. The cup forms a central aperture through the protrusion. The medical pump subassembly further comprises an electromagnetic coil within the recess and circumscribing the protrusion, a weld ring surrounding the recess, a barrier plate covering the recess, and a seal between the weld ring and the barrier plate to fluidically separate an interior of the cup from an external surface of the barrier plate. | 11-04-2010 |
| 20100280502 | MODULAR MEDICAL PUMP - An implantable medical device comprises a fluid reservoir configured to store a therapeutic agent; a port configured to deliver the therapeutic agent to a patient; a medical pump subassembly configured to actively transfer the therapeutic fluid from the fluid reservoir to the port; and a housing that contains the fluid reservoir, the port and the medical pump subassembly. The medical pump subassembly is configured to facilitate mechanical and electrical testing of the medical pump subassembly as a standalone component. | 11-04-2010 |
| 20100286668 | CAPSULE MEDICAL APPARATUS - A capsule medical apparatus includes a living tissue drawing portion in which a space for drawing the living tissue into a body of the capsule medical apparatus is formed; a movable unit that includes an engaging unit, which can be engaged with the living tissue of the subject, and that moves on a surface of the body of the capsule medical apparatus and in the living tissue drawing portion; an injection needle that has an ejection port for a drug and that protrudes such that the ejection port is positioned in the living tissue drawing portion; and an injection needle driver that drives the injection needle such that the injection needle protrudes. | 11-11-2010 |
| 20100298816 | MAGNETIC DELIVERY DEVICE - A method of delivering a reagent into a cell comprising positioning at least one cell, and at least one magnetically susceptible particle attached to the reagent, in the magnetic field of a Halbach array such that the magnetically susceptible particle is attracted to and contacts the cell is described together with an apparatus for delivery of the reagent. | 11-25-2010 |
| 20100305550 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball. | 12-02-2010 |
| 20100305551 | Valveless Impedance Pump Drug Delivery Systems - A drug-delivery unit suitable for implantation into a patient body may include a valveless impedance pump. In some implementations the unit may include an actuator, control electronics and a battery, and may communicate with an external patient interface unit. The patient interface unit can be used to control operation of the implant and to download data from the implant. The patient interface unit can also be used to charge the implant and/or a separate charger can be used. In other implementations, a drug-delivery implant unit may lack internal electronics and instead rely on an externally-supplied magnetic field to actuate the pump. | 12-02-2010 |
| 20110034908 | Device for actively removing a target component from blood or lymph of a vertebrate subject - Devices, systems, and methods are disclosed herein for modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject for treatment of a disease or condition in the vertebrate subject. An implantable device is provided which includes a body defining at least one lumen configured for fluid flow; at least one first reservoir in communication with at least one lumen; one or more energy sources configured to provide energy to elicit one or more signal responses associated with one or more labels that bind to one or more target components in one or more of blood fluid or lymph fluid of the vertebrate subject; one or more sensors configured to detect the one or more signal responses associated with one or more labeled target components; and one or more reactive components in communication with the at least one lumen for release responsive to the one or more sensors. | 02-10-2011 |
| 20110034909 | SAFETY LIMITS FOR CLOSED-LOOP INFUSION PUMP CONTROL - A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings. | 02-10-2011 |
| 20110040291 | TISSUE STIMULATING DEVICE AND METHOD - A tissue stimulating device that provides a biological stimulation of tissue has a release surface adapted for arrangement adjacent to a tissue to be stimulated. An agent reservoir of the device includes an ionic agent capable of causing a stimulation if present at sufficient high extracellular concentration close to the tissue. An agent releaser is provided in the device for releasing a selected amount of the ionic agent from the agent reservoir to an outside of the release surface at a stimulation occasion for stimulating the tissue. The ionic agent will cause a temporary change in ion permeability of the tissue cell membranes and a depolarization of the tissue cells. | 02-17-2011 |
| 20110060318 | METHODS AND SYSTEMS FOR PROVIDING METERED DOSES OF A COMPOUND TO AN INDIVIDUAL - An implantable pump for providing metered doses of a compound to an individual is described. The implantable pump includes a chamber for storing an individual dose of the compound, an inlet valve fluidly coupled to the chamber for controlling a flow of the compound into the chamber, and an outlet valve fluidly coupled to the chamber for controlling a flow of the compound out of the chamber and into the individual. The pump includes an inlet valve driver circuit operable for opening and closing the inlet valve, and an outlet valve driver circuit operable for opening and closing the outlet valve. A battery and a charging circuit that includes a capacitor are included in the implantable pump. The charging circuit is operatively coupled to the battery for charging of the capacitor. The charged capacitor is operable for supplying power to the valve driver circuits. | 03-10-2011 |
| 20110077623 | IMPLANTABLE BIO-MEDICAL UNIT WITH ELECTRO-MECHANICAL FUNCTION - A bio-medical unit includes a power harvesting module, a communication module, a processing module, and a micro electro-mechanical functional module. The power harvesting module converts a power source signal into a supply voltage that powers the other modules. The communication module converts inbound wireless communication signal into an inbound symbol stream and converts an outbound symbol stream into an outbound wireless communication signal. The processing module converts the inbound symbol stream into inbound data; generates a command message based on the inbound data; and converts an electro-mechanical response into the outbound symbol stream. The micro electro-mechanical functional module performs an electro-mechanical function within a hosting body in accordance with the command message and, when requested per the command message, generates the electro-mechanical response based on the performing the electro-mechanical function. | 03-31-2011 |
| 20110092960 | ENHANCED METHOD FOR DELIVERING BEVACIZUMAB (AVASTIN) INTO A BRAIN TUMOR USING AN IMPLANTED MAGNETIC BREATHER PUMP - A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. | 04-21-2011 |
| 20110092961 | Artificial cells - The present disclosure relates to various embodiments associated with artificial cells, particularly artificial antigen presenting cells, methods of making the same, methods of administering the same, computer systems relating thereto, computer-implemented methods relating thereto, and associated computer program products. | 04-21-2011 |
| 20110106064 | DEVICE FOR DELIVERY OF POWDER LIKE MEDICATION IN A HUMID ENVIRONMENT - A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir ( | 05-05-2011 |
| 20110125137 | IMPLANTABLE INFUSION DEVICE - An implantable infusion device includes a positive pressure reservoir, a pump, a flow restrictor, and an outlet. The device includes a first fluid flow path from the reservoir to the outlet, where the pump is downstream of the reservoir, and the outlet is downstream of the pump. The device further includes a second fluid flow path from the reservoir to the outlet, where the flow restrictor is downstream of the reservoir, and the outlet is downstream of the restrictor. The device may also include one or more controllable, MRI-safe valves to select whether fluid is delivered via the first or second flow path. | 05-26-2011 |
| 20110172646 | MULTI-MATERIAL SINGLE-PIECE ACTUATOR MEMBER FOR MINIATURE RECIPROCATING PISTON PUMP IN MEDICAL APPLICATIONS - An implantable medical device including a two piece actuator member which comprises a monocrystaline piston and a magnetizable pole. The monocrystalline piston is positioned within a piston channel having a surface having a titanium-oxide layer. The monocrystalline piston is selectively movable within the piston bore to permit intake and output of fluids. | 07-14-2011 |
| 20110184388 | BACTERIUM-BASED MICROROBOT FOR MEDICAL TREATMENT, OPERATION METHOD THEREOF AND TREATMENT METHOD USING THE SAME - Provided are a bacterium-based microrobot for medical treatment, an operation method thereof, and a treatment method using the same. The bacterium-based microrobot can be propelled by the flagellum movement of bacteria, can be directed toward a target lesion by the ability of bacteria to recognize the lesion, can be monitored for how many the microrobot targets the lesion, and can directly or indirectly treat the lesion by the proliferation of bacteria through self-division in the lesion. The bacteria may be genetically manipulated to be resistant to immune responses and produce a material inhibitory of the growth of affected cells. | 07-28-2011 |
| 20110184389 | OSMOTIC PUMP APPARATUS AND ASSOCIATED METHODS - Apparatuses and methods for pumping fluids such as fluid medications are disclosed. Embodiments of the invention provide an osmotic pump fluid delivery apparatus including elements designed to control the fluid delivery rate. Typical embodiments of the invention include an arrangement of elements such as solute reservoirs that can manipulate the solute concentrations within an inner osmotic compartment or compartments of an osmotic pump so as to control fluid delivery from the pump. Other embodiments include sealed electro-osmotic pumps that do not discharge ions into the surroundings or require water from an external source. These embodiments of the invention provide new ways to control fluid delivery in apparatuses that employ osmotic processes to function. | 07-28-2011 |
| 20110202041 | FASTENING MEANS FOR IMPLANTABLE MEDICAL CONTROL ASSEMBLY - A control assembly for implantation in a patient comprises a first unit adapted for subcutaneous implantation at a first side of a body tissue of said patient, a second unit adapted for implantation in a body cavity of said patient at a second side of said body tissue, wherein at least one of the first and the second unit is adapted to control an implanted powered medical device, and an interconnecting device adapted for mechanical interconnection of the first and second units to keep the assembly in place by the body tissue, the interconnecting device having a cross-sectional area which is smaller than the cross-sectional area of the first unit and the second unit in a plane parallel to the extension of the body tissue. | 08-18-2011 |
| 20110230865 | SUSTAINED DELIVERY OF AN ACTIVE AGENT USING AN IMPLANTABLE SYSTEM - The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved. | 09-22-2011 |
| 20110264076 | POLYOXAESTER SUSPENDING VEHICLES FOR USE WITH IMPLANTABLE DELIVERY SYSTEMS - Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created. | 10-27-2011 |
| 20110270233 | Implantable Infusion Device With Multiple Controllable Fluid Outlets - An implantable infusion system includes at least two controllable fluid transfer devices that may be used to transfer different fluid flows to the same or different body sites. | 11-03-2011 |
| 20110301575 | IMPLANTABLE MEDICAL PUMP WITH PRESSURE SENSOR - The disclosure is directed to a pressure sensor of an implantable medical device. The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self-aligning housing shape that occludes an opening in the pump bulkhead of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor. | 12-08-2011 |
| 20120004646 | IMPLANTABLE DEVICE SYSTEM - An implantable device system is disclosed. The implantable device system comprises, a first energy transceiver system, a second energy transceiver system at least partially implanted within an organic tissue and capable of being interrogated by the first energy transceiver system, and a sensing system, wherein a state of the sensing system is available at the second energy transceiver system. | 01-05-2012 |
| 20120022505 | Closed loop glaucoma drug delivery system - A device implantable into an eye of a patient for treatment of glaucoma. The device has an implantable sensor configured to measure at least one characteristic of the eye. The implantable sensor is sized for implantation into the eye. The device also has an implantable processor coupled to the sensor and configured to receive the measurement of the at least one characteristic of the eye and generate a signal based on the received measurement. Additionally, the device has an implantable actuator coupled to the processor and operable to release a dosage of a therapeutic agent into the eye in response to the signal from the implantable processor. | 01-26-2012 |
| 20120022506 | Drug delivery device with active iris - A device implantable into an eye of a patient for treatment of glaucoma. The device has an implantable dispenser. The dispenser includes an implantable reservoir configured to store a therapeutic agent. Additionally, the dispenser includes an implantable reservoir sensor configured to measure a pressure within the reservoir. The device also has an implantable processor coupled to the implantable reservoir sensor and configured to receive the measurement of the pressure within the reservoir and determine a dosage of therapeutic agent based on the measurement of the pressure within the reservoir. Furthermore, the implantable dispenser is configured to release the dosage of the therapeutic agent at a selectively variable rate from the implantable reservoir into the eye. | 01-26-2012 |
| 20120041427 | ELECTROLYTICALLY DRIVEN DRUG PUMP DEVICES - Electrolytically driven drug pump devices may be configured so as to ensure sustained contact of the electrolysis electrodes with the electrolyte, thereby improving the reliability and/or pump capacity of the devices. | 02-16-2012 |
| 20120046651 | MEDICAL DEVICE FOR GLUCOSE MONITORING OR REGULATION - A medical device comprising a pressure generating means adapted to displace a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration. | 02-23-2012 |
| 20120089130 | AUTOMATIC ELECTRONIC DELIVERY OF MEDICATION FOR VETERINARY AND OTHER USES - A bolus is provided with a housing, an ASIC; PCB; power source; devices for providing a gas-generating explosion, propelling means, antenna; electrodes; weights; medicament containers, and seals. These components provide a controlled delivery of a medicament in the stomach or rumen of an animal. | 04-12-2012 |
| 20120109112 | Ingestible Therapy Activator System and Method - An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The responder module may receive and process the effector instruction, resulting in a response by the therapeutic device. Examples of responses by therapeutic device include activating a therapy, deactivating a therapy, modulating a therapy, and discontinuing a therapy. | 05-03-2012 |
| 20120109113 | SAFETY LIMITS FOR CLOSED-LOOP INFUSION PUMP CONTROL - A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings. | 05-03-2012 |
| 20120116358 | MODULAR INGESTIBLE DRUG DELIVERY CAPSULE - An ingestible capsule ( | 05-10-2012 |
| 20120116359 | Integrated Ingestible Event Marker System With Pharmaceutical Product - A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention. In accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product. | 05-10-2012 |
| 20120116360 | TREATMENT OF NEUROLOGICAL DISORDERS - This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution. | 05-10-2012 |
| 20120123394 | SUSTAINED RELEASE CAPSULES - The invention relates to an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral. The capsule can have a dissolvable overcap moulded from plasticised starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule. A piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen. After insertion of the capsule in the animal the overcap (if present) dissolves and separates from the capsule to release the dump dose of medicament. The sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present). | 05-17-2012 |
| 20120130353 | Medication infusion device using negatively biased ambient pressure medication chamber - A method and apparatus for infusing medication into a patient's body using a medication chamber referenced to ambient pressure. The apparatus includes a medication chamber enclosed by a peripheral wall which includes a movable portion configured to transfer exterior ambient pressure into the chamber. Means are provided for exerting a negative bias force acting on the movable portion in a direction opposed to the ambient pressure force. Thus, the resultant pressure in the chamber will be negative with respect to ambient pressure, reducing the risk that the chamber can be overpressurized and produce an unintended medication discharge. | 05-24-2012 |
| 20120143171 | VALVELESS DRUG DELIVERY DEVICE - A drug delivery device ( | 06-07-2012 |
| 20120157976 | METHODS FOR TREATING NEUROLOGICAL CONDITIONS AND COMPOSITIONS AND MATERIALS THEREFOR - The present invention generally relates to methods, compositions and materials for treatment of and promotion of neurological functional recovery from neurological conditions including central nervous system injuries and/or diseases. | 06-21-2012 |
| 20120165796 | Pill Catchers - Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs. | 06-28-2012 |
| 20120184945 | TWO-PIECE, INTERNAL-CHANNEL OSMOTIC DELIVERY SYSTEM FLOW MODULATOR - An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system. | 07-19-2012 |
| 20120191074 | REDUCED SIZED PROGRAMMABLE PUMP - A reduced size implantable infusion pump is disclosed. The pump preferably includes a lower profile pump housing facilitated by specific propellant envelope configurations. For instance, the pump may include one or more c-shaped propellant envelopes that each define active substance and propellant chambers. | 07-26-2012 |
| 20120197238 | MEDICAL PUMP WITH FIXED STROKE LENGTH - A method comprises measuring a volume of fluid delivered per pump stroke for each of a plurality of substantially identical medical pumps. The substantially identical medical pumps each have a fixed stroke length. The method further comprises: storing indications of the measured volumes on one or more data storage mediums; and for each of the plurality of substantially identical medical pumps, generating a separate therapy control program based on the indication of the measured volume associated with that one of the plurality of substantially identical medical pumps. | 08-02-2012 |
| 20120203212 | REDUCTION OF INFLAMMATORY MASS WITH SPINAL CATHETERS - Devices, systems and methods for delivering one or more drugs to the cerebrospinal fluid periodically replace continuous infusion of the a solution with intermittent bolus infusion of the solution to reduce the local concentration of a drug over time at a vertebral level in the patient's spinal canal relative to the drug infused continuously through the infusion section of a catheter intrathecally into a patient's spinal canal at the vertebral level. Such periodic replacement of continuous infusion with intermittent bolus infusion assists in prevention formation of an inflammatory mass at the vertebral level. | 08-09-2012 |
| 20120226265 | REMOTELY CONTROLLED DRUG DELIVERY SYSTEMS - Drug delivery devices responsive to at least one external stimulus are described, along with methods for their preparation and use. The devices can be configured to respond to the stimulus, providing “on demand” release of one or more deliverables such as pharmaceutical drugs. | 09-06-2012 |
| 20120239007 | Implantable Devices and Methods for Treatment of Pain by Delivery of Fentanyl and Fentanyl Congeners - The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use. | 09-20-2012 |
| 20120245565 | METHOD FOR DELIVERING GENE AND CELL THERAPY TO A TUMOR OR TARGETED SITE USING AN IMPLANTED METRONOMIC BIOFEEDBACK PUMP - A method for utilizing a controlled pump implanted into a patient connected to a multilumen catheter allowing delivery to and sampling from the brain or other organ for treatment of a cancer. The pump delivers a plurality of medicating agents, including viral and non-viral vectors for gene therapy and cell therapy at a controlled rate, corresponding to the specific needs of the patient. A catheter is implanted in or adjacent to the tumoral region. Fluid drawn from the tumor region to the pump via the multilumen catheter is analyzed within the pump by various biofeedback sensors. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. The method allows localized delivery of gene and cell therapy to a solid tumor or tumoral region, or to any other treatment area of interest within the patient. | 09-27-2012 |
| 20120245566 | REDUCED SIZE IMPLANTABLE PUMP - A variable hydraulic resistor for use with implantable pumps is disclosed. The variable hydraulic resistor according to the present invention is particularly useful in varying the flow rate of a medication fluid from an otherwise constant flow implantable pump. An implantable pump is also disclosed, which does not require a complicated clinching system or the like, and which may include an undulating membrane and chamber design to reduce the height of the pump. | 09-27-2012 |
| 20120259318 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 10-11-2012 |
| 20120265174 | IMPLANTABLE FLUID DELIVERY DEVICE INCLUDING GAS CHAMBER PRESSURE SENSOR - An implantable medical device is configured with a pressure sensor arranged within the device to reliably and accurately measure the pressure within a propellant gas chamber at least partially surrounding a therapeutic fluid reservoir of the device. In one example, a housing of the IMD includes a protrusion that is configured to provide clearance for fluid communication between a propellant gas chamber pressure sensor and the propellant gas chamber. | 10-18-2012 |
| 20120277732 | Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage - A drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump mechanism or valve, and a drug delivery control means. The drug delivery control means comprises a controller, e.g., a microprocessor or microcontroller which is operable to automatically reduce the rate of drug delivery over a certain reduction interval (e.g., multiple days) from an initial dosage value to a final dosage value. | 11-01-2012 |
| 20120283703 | Flow Rate Accuracy of a Fluidic Delivery System - Improving the accuracy of the flow rate of a valve in a fluidic delivery device in which a desired flow rate may be achieved by varying the duty cycle of the valve. The flow rate of fluid delivery from the valve over its lifetime is stabilized by minimizing the voltage OPENING time of the valve to account for valve and piezoelectric actuator drift. Also, the valve OPENING time of one or more fluidic parameters that impact on the flow rate delivery by the valve and differ among fluidic delivery devices is compensated to optimize the flow rate accuracy. | 11-08-2012 |
| 20120283704 | DRUG INFUSION SYSTEM AND METHOD ADAPTED TO START DURING PROGRAMMING CYCLE - Drug infusion system capable of delivering a fluid medication to a patient and method for doing same is described. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time. | 11-08-2012 |
| 20120289943 | OSMOTIC PUMP WITH REMOTELY CONTROLLED OSMOTIC FLOW RATE - Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used. | 11-15-2012 |
| 20120302999 | Ingestible Device with Pharmaceutical Product - A system and a manufacturing process are disclosed in accordance with the present invention that protect an electronic device and allows for placement or combination of the device within a pharmaceutical product or capsule. The system includes circuitry and components that can be placed within certain environments. The device includes an assembly including an electronic unit, a flexible membrane secured to the unit, and a protective coating. | 11-29-2012 |
| 20120303000 | Regulator - A flow regulator ( | 11-29-2012 |
| 20120316540 | IMPLANTABLE DEVICE WITH CONFORMING TELEMETRY COIL AND METHODS OF MAKING SAME - A spiral-coil antenna conforming to a non-planar contour is deployed, in various embodiments, in an implantable device for controllably ejecting fluid into an anatomic region. The antenna facilitates wireless communications with the implantable device and external charging thereof. In one implementation, the device has a non-planar contour and the spiral coil defines a non-planar surface conforming to the non-planar contour. | 12-13-2012 |
| 20120330282 | TWO-PIECE, INTERNAL-CHANNEL OSMOTIC DELIVERY SYSTEM FLOW MODULATOR - An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system. | 12-27-2012 |
| 20130023857 | TWO WAY ACCUMULATOR PROGRAMMABLE VALVE PUMP - An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration. | 01-24-2013 |
| 20130030417 | Rapid Establishment and/or Termination of Substantial Steady-State Drug Delivery - The present invention is directed to treatment methods for a disease or condition, in a subject in need of such treatment, that provide alternatives to treatment by injection that give, relative to treatment by injection, improved treatment outcomes, 100% treatment compliance, reduced side effects, and rapid establishment and/or termination of substantial steady-state drug delivery. The method typically includes providing continuous delivery of a drug from an implanted osmotic delivery device, wherein substantial steady-state delivery of the drug at therapeutic concentrations is typically achieved within about 7 days or less after implantation of the osmotic delivery device in the subject and the substantial steady-state delivery of the drug from the osmotic delivery device is continuous over a period of at least about 3 months. In one embodiment, the present invention is directed to treatment of type 2 diabetes mellitus using incretin mimetics. | 01-31-2013 |
| 20130035669 | SUSTAINED DELIVERY OF AN ACTIVE AGENT USING AN IMPLANTABLE SYSTEM - The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved. | 02-07-2013 |
| 20130035670 | SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES - A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed. | 02-07-2013 |
| 20130066302 | INTRAUTERINE ELECTRONIC CAPSULE FOR ADMINISTERING A SUBSTANCE - An electronic capsule ( | 03-14-2013 |
| 20130096537 | IMPLANTABLE INFUSION DEVICE INCLUDING ANTI-SEALING RESERVOIR - Techniques are disclosed for reducing the accumulation of gases in an implantable infusion device. In one example, an implantable infusion device (IID) includes a housing, an expandable and contractible reservoir, and a standoff member. The expandable and contractible reservoir is configured to store a therapeutic agent and is arranged within the housing. A first end of the reservoir is configured to collapse toward a second end of the reservoir as the reservoir contracts. The standoff member is interposed between the first end and the second end of the reservoir and is configured to hold at least a portion of the first end offset from the second end when the reservoir is in a contracted state. | 04-18-2013 |
| 20130096538 | IMPLANTABLE PUMP WITH RESERVOIR LEVEL DETECTOR - An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil. A secondary magnetic field, which is dependant on the position of the bottom and intermediate plate of the bellow mechanism, couples back to the primary field affecting the electrical characteristics of the coil. The amount of fluid remaining in the reservoir is determined based on the resulting changes in the electrical characteristics of the coil. | 04-18-2013 |
| 20130103006 | MESH PROTECTION SYSTEM - An improved safety feature for preventing overdosage to a patient is disclosed. In one embodiment, the feature includes an improved screen member that prevents the inadvertent entry of a needle having too large a diameter. The screen member includes a plurality of holes that are configured so as to rid unwanted dead spaces that can damage an injection device during injection. Another embodiment of the safety feature includes a plurality of pins situated so as to similarly create a plurality of openings for reception of certain sized injection devices. Methods of providing a bolus dose to a patient are also disclosed. | 04-25-2013 |
| 20130116663 | Systems and methods for dynamic drug therapy response to blood pressure incidents - A dermal or transdermal drug-delivery skin patch has a blood pressure sensor structurally integrated or built into it. The skin patch when attached to a skin portion of an individual determines a blood pressure of the individual and in response needle-lessly delivers a treatment drug to the individual if necessary. | 05-09-2013 |
| 20130116664 | IMPLANTABLE DRUG PUMPS AND REFILL DEVICES THEREFOR - Implanted drug pump devices can be refilled via a fill port in the drug reservoir that includes a self-resealable septum. | 05-09-2013 |
| 20130116665 | IMPLANTABLE DRUG PUMPS AND REFILL DEVICES THEREFOR - Implanted drug pump devices can be refilled with a refill needle inserted through a fill port in the drug reservoir of the drug pump device. Proper needle insertion may be verified visually or using electrical, magnetic, optical, acoustic, or other suitable sensing mechanisms. | 05-09-2013 |
| 20130116666 | IMPLANTABLE DRUG PUMPS AND REFILL DEVICES THEREFOR - A system for refilling the drug reservoir of an implanted drug pump device may facilitate wireless data exchange between the refill system and the implanted device, e.g., to verify proper drug selection prior to commencement of the refill process. | 05-09-2013 |
| 20130116667 | SYSTEM FOR CONTROLLED ADMINISTRATION OF A SUBSTANCE FROM A HUMAN-BODY-IMPLANTED INFUSION DEVICE - A system for the controlled administration of a substance by means of an infusion device implanted in the human body is described. The system has an implantable unit for detecting a shortage or an excess of such substance or a physiological parameter correlatable to the shortage or excess of such substance, an infusion group of this substance implantable in the peritoneal cavity and having a central control unit for processing data received from the detection unit, and energy storage means to power such infusion group. The system also has a carrier of such substance adapted to be ingested, and a refilling device for refilling the infusion group with such substance. | 05-09-2013 |
| 20130197487 | Implantable Infusion Devices Including Apparatus For Confirming Fluid Flow And Systems, Apparatus And Methods Associated With Same - Implantable infusion apparatus, systems and methods that involve the use of a sensor that is associated with the catheter outlet. | 08-01-2013 |
| 20130204233 | DRUG DELIVERY DEVICE WITH COMPRESSIBLE DRUG RESERVOIR - A drug delivery device ( | 08-08-2013 |
| 20130245614 | FAULT MONITOR FOR FAULT TOLERANT IMPLANTABLE PUMP - A implantable pump system comprises an implantable pump motor and an external unit. An inverter comprises respective phases with redundant legs connected in parallel, and respective current sensors in series with each leg generating a respective measured current. A cable redundantly couples the inverter to the motor. The cable includes a respective conductor coupling each redundant leg to a respective phase of the motor. The controller receives the measured currents, monitors for a fault in the conductors by comparing the measured currents in the respective redundant legs. A fault in a pair of redundant conductors is detected if a ratio of the respective measured currents is not within a predetermined range. | 09-19-2013 |
| 20130289538 | Charge Pump Sequencing for Minimizing In-Rush Current - An implantable infusion device includes a voltage boost circuit configured to selectively generate an output voltage from a first voltage provided by a battery. The voltage boost circuit includes a signal generation circuit configured to generate control signals and a charge pump circuit configured to generate the output voltage in response to the control signals. In response to a request for a predetermined voltage, the signal generation circuit generates the control signals using a first profile for a first period of time, and generates the control signals using a second profile for a second period of time subsequent to the first period. The charge pump circuit increases the output voltage to (i) an intermediate voltage less than the predetermined voltage in response to the first profile of the control signals, and (ii) the predetermined voltage in response to the second profile of the control signals. | 10-31-2013 |
| 20130289539 | Power Management System for a Piston-Based Implantable Infusion Pump - An implantable infusion device includes a pump, a charge storage unit, and a charging circuit configured to supply current to the charge storage unit from a battery in preparation for actuating the pump. The implantable infusion device also includes a pump actuator circuit configured to actuate the pump using energy from the charge storage unit, and a voltage boost circuit configured to provide a boosted battery voltage generated from the battery. The charging circuit is configured to supply current to the charge storage unit from the voltage boost circuit instead of directly from the battery in response to (i) a comparison of a voltage of the battery with a predetermined threshold and (ii) a comparison of a voltage of the charge storage unit with the voltage of the battery. | 10-31-2013 |
| 20130289540 | IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM - The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells. | 10-31-2013 |
| 20140039469 | REDUCED SIZE IMPLANTABLE PUMP - A variable hydraulic resistor for use with implantable pumps is disclosed. The variable hydraulic resistor according to the present invention is particularly useful in varying the flow rate of a medication fluid from an otherwise constant flow implantable pump. An implantable pump is also disclosed, which does not require a complicated clinching system or the like, and which may include an undulating membrane and chamber design to reduce the height of the pump. | 02-06-2014 |
| 20140135743 | System and Method for Correction of Intracerebral Chemical Imbalances - A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit. A system for treating disorders of the central nervous system (CNS), comprises first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient's CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS and a first reservoir imlpantable within the patient's body and holding material to be introduced to the CNS in combination with a first pump coupled to the first reservoir and the first conduit for introducing the material to the CNS via the first conduit and a brain wave detection unit for detecting and analyzing brain waves of the patient. | 05-15-2014 |
| 20140142556 | IMPLANTABLE DRUG DELIVERY DEVICES - The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers. | 05-22-2014 |
| 20140200559 | Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type I diabetes applications - A controller for an artificial pancreas for automated insulin delivery to patients with type 1 diabetes mellitus (T1DM) that enforces safe insulin delivery throughout both day and night, wherein the controller employs zone model predictive control, whereby real-time optimization, based on a model of a human's insulin response, is utilized to regulate blood glucose levels to a safe zone, and time-dependent zones that smoothly modulate the controller correction based on the time of day, wherein the controller strategically strives to maintain an 80-140 mg/dL glucose zone during the day, a 110-220 mg/dL zone at night, and a smooth transition of 2 hour duration in between. | 07-17-2014 |
| 20140207122 | Drug Delivery Safety System - A drug delivery safety system includes a programmer with a display and a communications device adapted to communicate with an ambulatory medical device. The programmer has access to a database of information, and is adapted to receive and process the information and a user input and to control the display to provide a graphical user interface that prompts a user of the programmer to provide an additional user input when the user input requests a drug delivery protocol for the ambulatory medical device that is not already stored in the database as a clinician-approved drug delivery protocol. | 07-24-2014 |
| 20140214010 | DRUG DELIVERY DEVICE WITH COMPRESSIBLE FLUID CHAMBERS - A drug delivery device utilizing compressible fluid chambers for actuation is disclosed. The device includes a compressible dispensing chamber situated in a first compartment and a compressible filler-fluid chamber in flow communication with the first compartment. The compressible dispensing chamber is attached with a reciprocating plunger for dispensing the drug fluid. The drug chamber is refillable with a refill container that uses a compressible pouch containing the refill drug fluid. The refilling process is failsafe enabled by the insertion of the refill container needle only at the correct position to activate an internal contact switch. The compressible-wall configurations enable low dispensing forces without leakage of the drug fluid. | 07-31-2014 |
| 20140288535 | Intragastric Volume Occupying Device with Active Agents - An implantable intragastric volume occupying device system is provided which generally includes a volume occupying device and an active agent, for example, a metabolic agent or satiety inducing agent. The volume occupying device may be structured to contain the agent and permit controlled release of the agent to the patient while the volume occupying device is positioned within the patient's stomach. Methods for treating obesity are also provided which include positioning a volume occupying device in the stomach of a patient and administering a satiety inducing agent to the patient while the volume occupying device is positioned in the stomach. In one embodiment, the active agent may be contained in a reservoir and dispensed to a portion of the patient's body. | 09-25-2014 |
| 20140330256 | Implantable Device for Manipulating Immune Cells - Systems, devices, methods, and compositions are disclosed which include an actively-controllable implantable device configured to, for example, capture and/or release biochemical and/or biological cells in a subject. | 11-06-2014 |
| 20140330257 | Implantable Device for Manipulating Immune Cells - Systems, devices, methods, and compositions are disclosed which include an actively-controllable implantable device configured to, for example, capture and/or release biochemical and/or biological cells in a subject. | 11-06-2014 |
| 20140350529 | Sustained Release Capsules - The invention relates to an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral. The capsule can have a dissolvable overcap moulded from plasticised starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule. A piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen. After insertion of the capsule in the animal the overcap (if present) dissolves and separates from the capsule to release the dump dose of medicament. The sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present). | 11-27-2014 |
| 20140364839 | Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage - A drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump mechanism or valve, and a drug delivery control means: The drug delivery control means comprises a controller, e.g., a microprocessor or microcontroller which is operable to automatically reduce the rate of drug delivery over a certain reduction interval (e.g., multiple days) from an initial dosage value to a final dosage value. | 12-11-2014 |
| 20140371727 | Implantable Device For Drug Delivery Operated By Magnetic Force - Disclosed is an implantable device for drug delivery operated by a magnetic force. The device is provided with a body member and an external magnetic controller which is able to move some of the parts in the body member so that the drug inside the body member can be delivered to a site of interest of the animal body without the extra power source. | 12-18-2014 |
| 20150025509 | Implantable Fluid Delivery Apparatus and Implantable Electrode - A fluid delivery system includes an implantable fluid source, a first catheter in fluid communication with the implantable fluid source, and an implantable micro-valve in fluid communication with the first catheter, the micro-valve configured to be located within a round window or to be secured to a promontory bone of a cochlea | 01-22-2015 |
| 20150038948 | Apparatus and use of a neurochemisrty regulator device insertable in the cranium for thetreatment of cerebral cortical disorders - A subarachnoid pharmacodialysis apparatus insertable under the scalp, in and under the cranium, with a relatively short and simple neurosurgical procedure, to be kept there safely implanted for a year or longer for the purpose of regulating the neurochemistry of one or more diseased cerebral cortical areas and thus to achieve therapeutic effects via both localized delivery of medication and drainage of local neurotoxic molecules across the subdural meninges and compartments in a feedback-controlled fashion, with or without the additional capability of performing localized neurochemistry regulation in subcortical areas. This apparatus is also used for neurochemical profiling of the diseased brain area or areas by analyzing the removed endogenous molecules and adjusting the composition of the delivered medication based on the patient's specific, abnormal neurochemistry within the treated area or areas. | 02-05-2015 |
| 20150038949 | SYSTEMS AND METHODS FOR DRUG DELIVERY, TREATMENT, AND MONITORING - Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. | 02-05-2015 |
| 20150051589 | CAPSULE TYPE MEDICAL DEVICE AND MEDICAL SYSTEM - Provided is a capsule type medical device which is able to be suspended in a body cavity. The capsule type medical device performs continuous treatment while being suspended at a predetermined site. | 02-19-2015 |
| 20150088102 | NANOCHANNELED DEVICE WITH ELECTRODES AND RELATED METHODS - A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, electrodes and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel. | 03-26-2015 |
| 20150094697 | MEDICAMENT DELIVERY SYSTEMS - Described herein are systems, devices, and methods for the delivery of substances to, or the sampling of substances from, a patient using a portable and preferably implantable device. The substances introduced to and/or taken from the patient are preferably fluidic and are driven by a miniature pump, such as a microimpedance pump. A number of design variations are explicitly and implicitly described, such as the use of multiple pumps and multiple reservoirs for containing medicaments. Methods of manufacture of these systems and devices are also described, for instance, using molding, micromachining, or lithographic processes. | 04-02-2015 |
| 20150297828 | IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM - The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immuno-rejection of the host body or of the host to the secretory cells. | 10-22-2015 |
| 20150351897 | MOBILE BIO-SCAFFOLD CONTROLLED BY MAGNETIC FIELD AND METHOD OF MANUFACTURING THE SAME - A mobile bio-scaffold controlled by a magnetic field is provided. A mobile bio-scaffold controlled by a magnetic field according to the present invention comprises a spherical body including a first ring, a second ring connected to the first ring that intersects the second ring, and a third ring connected to the first and second rings that intersect the third ring, with a plurality of openings being defined by the first to third rings. A magnetic layer is disposed on the spherical body. The spherical body rotates through interaction between the magnetic layer and a rotational magnetic field applied from an external source, thereby moving by rolling in a single direction. | 12-10-2015 |
| 20150367067 | Programming and Bolus Monitoring Device for an Implantable Drug Pump - A programming device for an implantable drug pump includes a display device, a communication device, and a controller. The communication device is adapted to facilitate a communication link between the programming device and an implantable drug pump. The controller adapted to receive bolus data stored on the implantable drug pump when the communications link has been established, to process the bolus data, and to control the display device to generate a visual representation of numbers of bolus attempts for multiple periodic time intervals. | 12-24-2015 |
| 20160000602 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. When a predetermined cracking pressure is reached, a valve opens and allows the liquid to flow through the cannula. | 01-07-2016 |
| 20160067467 | SYSTEMS, METHODS, AND DEVICES ADDRESSING THE GASTRO-INTESTINAL TRACT - Various embodiments disclosed herein relate to an implantable device, systems, and methods related thereto, that includes at least one sensor and/or therapeutic agent delivery depot. In one embodiment, the system and device include means for detecting general or specific biological agents in a subject's intestinal tract, and utilizing the information from the detection for determining the timing and content of any therapeutic treatment needed by the subject. | 03-10-2016 |
| 20160074323 | MICROCHIP SUBSTANCE DELIVERY DEVICES HAVING LOW-POWER ELECTROMECHANICAL RELEASE MECHANISMS - Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity. | 03-17-2016 |
| 20160192994 | AEMS Compendium | 07-07-2016 |
| 20170232193 | Diagnostic Transceiver Assembly | 08-17-2017 |
