| Entries |
| Document | Title | Date |
|---|
| 20080208173 | Insulin Pump Having Triple Functions Which Enables Efficient Control of Blood Glucose Concentration and Insulin Injection System Comprising the Same - The present invention relates to an insulin pump having triple functions for the efficient regulation of a blood glucose concentration and an insulin injection system comprising the same. The insulin pump comprises an insulin syringe into which an insulin is stored, a pump to pressurize the insulin syringe in response to a programmed control signal, a control device that generates the programmed control signal to control the pump, a mode selection button to determine an insulin injection mode, and an operating button to command an insulin injection. The insulin injection mode is comprised of a base mode that continuously infuses the insulin at a basic rate to control a blood glucose concentration at a fasting, a food mode that infuses the insulin at a bulk to control the blood glucose concentration after food intake, and an activation mode that infuses the insulin in pulses for a predetermined time period. Preferably, the insulin pump complementarity cooperates with a physiological saline syringe pump that infuses physiological saline solution immediately after the infusion of the insulin at the activation mode. | 08-28-2008 |
| 20080215037 | Temperature responsive systems - A shape memory material activated device of the present invention uses a shape memory material activator to create a path through a shell wall of the device. The path through the shell wall may release a substance contained in the shell or allow a substance to enter the shell. The path may be created by fracturing, puncturing, exploding, imploding, peeling, tearing, stretching, separating, debonding, abrading or otherwise opening the shell and, may be permanent or reversible. The substance may be released in one location while the device is stationary or along a path while it is traveling, self-powered by the shape memory material activator. In addition, the substance may be delivered to an object upon contact with its surface. The self powering abilities allow these devices to be used as substance delivery devices as well as actuators, transporters, and energy conversion systems with modular characteristics and growth potential. The devices may be armed, prior to the beginning of their service life, to be placed in a state of readiness to release their substances once the path is created. Prior to arming they may be maintained at any temperature, incapable of releasing their substances. The devices according to the present invention may be used as temperature sensors or warning devices, drug delivery devices, and the like. | 09-04-2008 |
| 20080221555 | METHOD FOR WIRELESSLY MONITORING IMPLANTED MEDICAL DEVICE - A method is provided for monitoring the status of a medical device implanted in a patient. The method includes the steps of implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics for disintegrating or permeabilizing the reservoir cap, and (iv) a telemetry system; and then using said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein. | 09-11-2008 |
| 20080221556 | Device For the Controlled Release of a Predefined Quantity of a Substance - The application provides a device ( | 09-11-2008 |
| 20080234663 | Method for Selecting Bolus Doses in a Drug Delivery System - A method, apparatus and system for selecting a bolus dose of a drug in a drug delivery device is disclosed. The method comprises selecting the bolus dose from a pre-determined schedule of bolus doses, wherein each dose corresponds to a range of a body analyte levels. | 09-25-2008 |
| 20080249510 | MEMBRANE-BASED FLUID CONTROL IN MICROFLUIDIC DEVICES - A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity. | 10-09-2008 |
| 20080262478 | Device for Controlled Release of Chemical Molecules - The invention relates to a device comprising an ingestible capsule which measures at least one body parameter and starts a drug release program upon predefined changes in the body parameter. | 10-23-2008 |
| 20080269723 | CLOSED LOOP/SEMI-CLOSED LOOP THERAPY MODIFICATION SYSTEM - A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to compare the measured blood glucose value to a target blood glucose value and adjust a therapy delivery parameter if the measured blood glucose value is not consistent with the target blood glucose value, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter. | 10-30-2008 |
| 20080275430 | Prolonged Transit Time of Permeability-Enhancing Drug Eluting Pill - Apparatus is provided for drug administration. The apparatus includes an ingestible capsule, which includes a drug, stored by the capsule. The apparatus also includes an environmentally-sensitive mechanism, adapted to change a state thereof responsively to a disposition of the capsule within a gastrointestinal (GI) tract of a subject; one or more drug-passage facilitation electrodes; and a control component, adapted to facilitate passage of the drug, in response to a change of state of the environmentally-sensitive mechanism, by driving the drug-passage facilitation electrodes to apply an electrical current. The apparatus further includes a velocity-reduction element adapted to reduce a velocity of the capsule through the GI tract for at least a portion of the time that the control component is facilitating the passage of the drug. Additional embodiments are also described. | 11-06-2008 |
| 20080281297 | Method and device for drug delivery - A method and a device for a delivery of a chemical substance to the body of the patient are provided. The device includes an infusion catheter configured to be inserted into a tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient. | 11-13-2008 |
| 20080287922 | User Interface for Delivery System Providing Graphical Programming of Profile - The invention provides a delivery system comprising a reservoir and an expelling assembly to expel drug out of the resorvoir. The system further comprises a display for graphically displaying a profile showing a first parameter as a function of a second parameter, the profile comprising at least one segment, each segment indicating an interval for the second parameter and an associated value for the first parameter, wherein each segment has a starting and an ending value for the first parameter. The display further shows an indicator arranged corresponding to a given value for the second parameter. User input means is provided allowing a user (i) to move the indicator corresponding to a desired value for the second parameter for the displayed profile, and (ii) to adjust the first parameter for a segment defined by the actual position of the indicator and an adjacent starting or ending point for a neighbouring segment. | 11-20-2008 |
| 20080319424 | Devices and Methods for Delivering Therapeutic Substances for the Treatment of Sinusitis and Other Disorders - Devices and methods for delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects. An implantable delivery device comprising a reservoir is initially attached to a deliver catheter or delivery tool and is introduced into the body and positioned at a desired site. A therapeutic or diagnostic substance is then introduced into the reservoir and the delivery catheter or deliver tool is then removed, leaving the implantable delivery device implanted within the body. The substance is then delivered from the reservoir at a rate that causes the desire diagnostic or therapeutic effect. Also provided are substance eluting stents that elute substance from a selected surface of the stent (e.g., the outer surface) but not from another surface of the stent (e.g., the inner surface). | 12-25-2008 |
| 20090012502 | Oxygen Supply for Cell Transplant and Vascularization - Apparatus is provided, including a housing ( | 01-08-2009 |
| 20090024112 | MEDICAL INJECTOR WITH COMPLIANCE TRACKING AND MONITORING - A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal. | 01-22-2009 |
| 20090024113 | MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS - An implantable medical device is provided for controlled delivery or exposure of reservoir contents. The device may include a substrate; a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate; reservoir contents disposed in the reservoirs; a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo, wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo. For example, to enhance the resistance of the substrate to etching in vivo, the interior sidewalls of the reservoirs may include a protective coating (such as gold, platinum, carbon, silicon carbide, silicon dioxide, or platinum silicide), or the sidewalls may include a doped silicon. | 01-22-2009 |
| 20090030403 | Methods and Systems for Attenuating the Tolerance Response to a Drug - Methods are provided for modulating a drug response comprising determining that a patient has an elevated or reduced susceptibility for a neurological event; outputting a signal that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to modulate the patient's susceptibility for the neurological event, wherein the drug response is modulated. Systems are also provided for treating epilepsy comprising an electrode array configured to receive a signal from a patient; a processing assembly configured to receive and process the signal to determine the patient's susceptibility for a neurological event; an output assembly configured to produce an output that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to reduce the patient's susceptibility for the neurological event, wherein the drug response to the pharmacological agent is attenuated. | 01-29-2009 |
| 20090036875 | CARDIAC TISSUE THERAPY - A method and apparatus for treating tissue of a heart of a patient includes delivering a carrier to an epicardial surface of the heart. The carrier has a therapeutic agent selected for treating cardiac tissue. The agent is releasable from the carrier over a period of time following placement of the carrier at the epicardial surface of the heart. The carrier is contained within a delivery tool at a first geometry and changes to a second geometry following delivery of the carrier from the tool. | 02-05-2009 |
| 20090043288 | Temperature responsive systems - A shape memory material activated device of the present invention uses a shape memory material activator to create a path through a shell wall of the device. The path through the shell wall may release a substance contained in the shell or allow a substance to enter the shell. The path may be created by fracturing, puncturing, exploding, imploding, peeling, tearing, stretching, separating, debonding, abrading or otherwise opening the shell and, may be permanent or reversible. The substance may be released in one location while the device is stationary or along a path while it is traveling, self-powered by the shape memory material activator. In addition, the substance may be delivered to an object upon contact with its surface. The self powering abilities allow these devices to be used as substance delivery devices as well as actuators, transporters, and energy conversion systems with modular characteristics and growth potential. The devices may be armed, prior to the beginning of their service life, to be placed in a state of readiness to release their substances once the path is created. Prior to arming they may be maintained at any temperature, incapable of releasing their substances. The devices according to the present invention may be used as temperature sensors or warning devices, drug delivery devices, and the like. | 02-12-2009 |
| 20090048583 | INTRAVASCULAR DELIVERY SYSTEM FOR THERAPEUTIC AGENTS - Described herein is a system for intravascular drug delivery system, which includes a reservoir implantable a blood vessel, an intravascular pump fluidly coupled to the reservoir and an anchor expandable into contact with a wall of the blood vessel to retain the system within the vasculature. Delivery conduits may be extend from the reservoir and are positionable at select locations within the vasculature for target drug delivery to select organs or tissues. | 02-19-2009 |
| 20090054877 | Acoustically controlled substance delivery device - Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used. | 02-26-2009 |
| 20090062777 | ADMINISTRATION APPARATUS FOR MEDICAL USE - An expansion/compression mechanism of a piston rod assembly is composed of a bush shaft, a first cylindrical piston rod that is screwed with the bush shaft, a second cylindrical piston rod that is screwed with the first piston rod, and a piston rod holding member for housing the bush shaft and these piston rods. Therefore, the piston rods move linearly in multiple stages. | 03-05-2009 |
| 20090062778 | Medical System Comprising Dual-Purpose Communication Means - The present invention relates to secure paring of electronically controlled devices adapted to communicate with each other. Thus, a medical system is provided comprising a first unit and a second unit, the system comprising first means of communication allowing a first group of data types to be transmitted between the first unit and the second unit, the first unit comprising an acoustic transducer having a transducer coil with a plurality of windings, the transducer coil serving as an antenna for wireless signals transmitted between the first and second units. In this way a “par-=asite” property of the acoustic transducer can be used, i.e. using the coil as a receiving means, thereby replacing a receiving structure, e.g. a separate receiver coil or an antenna, which would otherwise have to be provided, this reducing manufacturing costs. | 03-05-2009 |
| 20090088731 | Infusion Device Menu Structure and Method of Using the Same - A portable infusion system that is programmable by an individual for delivering fluid from a reservoir into a user includes a drive mechanism, an input device, a processor, and a display. The drive mechanism forces the fluid out of the reservoir, and the input device accepts one or more inputs. The processor uses one or more of the one or more inputs to control the drive mechanism. The display receives information from the processor and visually displays one or more screens containing the information. At least one of the one or more screens includes a menu with at least two menu items, and the input device is used to select one menu item from amongst the at least two menu items. | 04-02-2009 |
| 20090112188 | DEVICE FOR CONTROLLING EXPOSURE OF RESERVOIR CONTENTS TO SURROUNDINGS - Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture. | 04-30-2009 |
| 20090118710 | Non-invasive analysis and controlled dosage transdermal active patch - A programmable transdermal patch non-invasively delivers pharmaceuticals or other bio-active agents through the skin of a living body. The patch contains one or more agent storage pads and one or more active drivers that apply an electric current to the skin or produce ultrasound to drive the agent into the skin. A digital data processor controls the drivers to match administration of the agents to the needs of the body. The patch may contain a sensor, coupled to the data processor, for monitoring the concentration of a substance in the body in order to vary dosage of a therapeutic agent. A radio contained in the patch enables control by medical personnel from a remote location and/or transmission of sensor data to the remote location. The pads, drivers, sensor, data processor, radio and a battery are all contained within a unitary patch and need no physical connection to external devices. | 05-07-2009 |
| 20090131918 | DEVICE AND METHOD FOR THE CONTROLLED RELEASE OF A PREDEFINED QUANTITY OF A SUBSTANCE - This invention provides a device for the controlled release of a predefined quantity of a substance and a method of controllably releasing a predefined quantity of a substance from a compartment ( | 05-21-2009 |
| 20090137987 | METHOD AND APPARATUS FOR MULTI-INPUT STEPWISE INFUSION PRESCRIPTION - A drug infusion device includes a drug delivery module which delivers a drug in each of a series of sequential time slots over a period of time. The drug delivery module is controlled by a controller which is configured to cause the drug delivery module to deliver said drug in the series of sequential time slots in a manner defined by a formula in which a quantitative characteristic of drug delivery in each time slot is a function of a past drug delivery profile and at least one of: a) a medical professional-provided profile, b) a patient-chosen parameter, and c) a non-variable parameter. The formula may be a function of a medical professional-provided profile and a non-variable parameter may be a parameter chosen by a medical professional. The past drug delivery profile may include a drug delivery parameter in a previous time slot. The patient-chosen parameter may include an input from the patient characterizing the patient's condition. | 05-28-2009 |
| 20090149838 | Subcutaneous Implant System - Implantable subcutaneous drug delivery devices for treating chronic nerve pain, and methods of use thereof, are disclosed. The device includes a reservoir having a septum, and a flexible tube in fluid flow communication with the reservoir, with at least a portion of the tube having a plurality of sidewall apertures. The device is implanted such that the apertures are disposed proximal to the desired tissue for contacting the desired tissue with medicine, and the reservoir is disposed in an unobtrusive location distal from the desired tissue. Medicine is periodically and repeatedly percutaneously charged to the device via a cannula introduced from outside the body. | 06-11-2009 |
| 20090149839 | Treatment techniques using ingestible device - An apparatus, device, methods, computer program product, and systems are described that determine a control command at a patient internal device within a patient, and provide the control command to an ingestible device within the patient, the control command including instructions to the ingestible device to control an operation thereof. | 06-11-2009 |
| 20090171324 | Reservoir Pressure Equalization Systems and Methods - Various embodiments of the present invention are directed to equalizing pressure in a reservoir containing fluidic media, possibly due to imperfect installation of the reservoir or an external influence such as an altitude or a temperature change. In various embodiments, fluidic media may be expelled from the reservoir through a needle and contained in an interior volume of a pierceable member before the needle pierces the pierceable member to establish a flow path to a user. In other embodiments, fluidic media may be expelled through a port of the reservoir into a chamber. In further embodiments, fluidic media may be expelled through a channel in a plunger head and out a passage in the reservoir when the channel and passage are aligned. In other embodiments, fluidic media may be expelled through a valve, and the valve may be pierceable by a needle to establish a flow path to the user. | 07-02-2009 |
| 20090177188 | Method and device for controlling several infusion pumps - The invention concerns a method and device for controlling a number of infusion pumps ( | 07-09-2009 |
| 20090192500 | MEDICAL DEVICE FOR ACTIVE DRUG DELIVERY VIA SOLAR ENERGY - A surface wearable or implanted medical device suitable for delivering therapeutic agents to the body as well as monitoring and analyzing analytes in bodily fluids. The device utilizes a photovoltaic cell or miniature solar panel as an energy source in conjunction with microtubules or membranes, a therapeutic agent or analyte reservoir, an adhering structure, and a means of regulating and monitoring the agents and analytes. The device is adhered to the tissue of the recipient and by controlling the polarity of the current between the tissue and reservoir the flow of agents into the body can be controlled and regulated, just as the rate of removal of analytes from the body can also be regulated. This regulating, analyzing, and monitoring can be controlled by the absence or presence of light or may involve a computerized system that utilizes a transmitter and receiver or visual display system. | 07-30-2009 |
| 20090240240 | Disposable infusion device with actuation lock-out - An infusion system includes a wearable infusion device, a safety assembly, and a tool. The device includes a liquid medicament dispenser having a base attachable to a patient's skin and that, when enabled, causes the liquid medicament to flow to beneath the skin of the patient, and an actuator that, when engaged, enables the dispenser. The safety assembly precludes unintended engagement of the actuator and the tool is arranged to disable the safety assembly. | 09-24-2009 |
| 20090254067 | Fluid delivery device - A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as antibiotics, oncolytics, hormones, steroids, blood clotting agents, analgesics, and like medicinal agents from prefilled containers at a uniform rate. The dispenser uniquely includes a stored energy source that is provided in the form of a compressible-expandable elastomeric member of novel construction that provides the force necessary to continuously and uniformly expel fluid from the device reservoir. The device further includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient. | 10-08-2009 |
| 20090259214 | Agent delivery device - The present disclosure relates to agent delivery devices and related systems. | 10-15-2009 |
| 20090275923 | ELECTRONIC CAPSULE FOR TREATING GASTROINTESTINAL DISEASE - The present invention discloses an ingestible capsule containing drug and a method for controlled administration of the drug in a mammal for treatment of a disease of the GI tract. The capsule has electronic control means for dispensing the drug substantially to the diseased tissue sites of the GI tract, according to a pre-determined drug release profile obtained prior to administration from the specific mammal. | 11-05-2009 |
| 20090306632 | MEDICAMENT DELIVERY SYSTEM AND PROCESS - A system and method for delivering a substance to a selected site in the alimentary canal of a human or animal is provided. The system has an ingestible capsule comprising: a compartment for storing the substance; a receiver suitable for receiving a signal through animal tissue; a processor for storing a programmed set of instructions; an electronic power source; and at least one transmitter, disposed on a medically relevant site on the body of the human or animal, for sending a signal to the receiver, wherein the receiver further comprises a proximity based detection means for measuring proximity of the receiver to the at least one transmitter, and wherein the processor instructs the releasing means to release the substance upon recognition of a pre-programmed pattern of transmitters. | 12-10-2009 |
| 20090326516 | Preparatory dispensation systems and methods - Methods and systems are described for receiving wireless control signal content into a module containing one or more active ingredients and causing one or more dispensations from the module according to a programmatic dispensation profile partly dependent on the wireless control signal content and partly dependent on an attribute of the module; or for obtaining data indicating a future event time intended by an individual, and causing a bioactive material administration to the individual in response to the data to occur about or before the future event time. | 12-31-2009 |
| 20100030198 | DRUG DELIVERY PLATFORM UTILIZING HYDROGEL PUMPING MECHANISM - A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a pressure source engageable with the reservoir. The pressure source is movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom. An output conduit is provided for transmitting the drug into the individual. An actuation mechanism is operatively connected to the pressure source and the output conduit. The actuation mechanism is movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output end of the output conduit is receivable in the individual. | 02-04-2010 |
| 20100042075 | MULTI-OPENING RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS - Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. | 02-18-2010 |
| 20100049172 | Sensing and interactive drug delivery - An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject. | 02-25-2010 |
| 20100057057 | Closed Loop Control And Signal Attenuation Detection - Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting a signal level associated with the monitored physiological condition deviating from a predetermined threshold level, retrieving the medication level administered associated with a time period of the detected signal level, applying the retrieved medication level to the detected signal based on a predefined predictive model to generate a predictive signal, and comparing the detected signal to the predictive signal to determine whether a condition associated with the detected signal level is present are provided. | 03-04-2010 |
| 20100057058 | CASSETTE FOR USE IN A MEDICATION DELIVERY FLOW SENSOR ASSEMBLY AND METHOD OF MAKING THE SAME - A disposable assembly for use with a sensor assembly comprises a body, a flow restricting element, and a fluid pressure membrane. The body has a lid portion and a base portion. The body defines a fluid flow passage that forms an inlet and an outlet. The flow restricting element is positioned in the fluid flow passage between the inlet and the outlet. The membrane is located between the lid and base portions along the fluid flow passage. A reinforcing structure, such as a ring or a rigid disk, is positioned between the fluid pressure membrane and the lid portion to provide increased resistance to pressure in the fluid flow passage. The ring or disk can be a separate component or formed on the membrane. The membrane thickness adjacent to sensor access openings in the lid portion can be increased for pressure resistance, too. | 03-04-2010 |
| 20100063485 | DEVICE FOR THE CONTROLLED RELEASE OF A PREDEFINED QUANTITY OF A SUBSTANCE - Device for the controlled release of a predefined quantity of a substance and method for the production of a device for the controlled release of a predefined quantity of a substance. To realize a controlled delivery of a substance based upon a multiplicity of individual compartments, the reservoirs are formed in plastic substrates that allow the substance delivery device to be flexible and conformal with both internal and external body parts. The fabrication technology for the plastic drug release reservoirs is compatible with active matrix array technology, allowing control of delivery to be based upon active matrix principles. Applications are for controlled external drug delivery (patches), implantable drug delivery and oral drug delivery (electronic pill). | 03-11-2010 |
| 20100063486 | MEDICAMENT DELIVERY APPARATUS - An electronic capsule ( | 03-11-2010 |
| 20100069887 | Multiple chamber ex vivo adjustable-release final dosage form - Described embodiments include a final dosage form, an article of manufacture, and method. A described final dosage form includes a dosage portion having a chamber carrying a medicament. The dosage portion also has a release element in a first medicament-release state wherein the medicament has a first bioavailability to the animal. The release element is modifiable ex vivo to a second medicament-release state by an exposure to a stimulus, wherein the medicament has a second bioavailability to the animal. The final dosage form includes another dosage portion having another chamber carrying another medicament. The another dosage portion also has another release element in another first medicament-release state wherein the another medicament has another first bioavailability to the animal. The another release element is modifiable ex vivo to another second medicament-release state by an exposure to another stimulus, wherein the another medicament has another second bioavailability to the animal. | 03-18-2010 |
| 20100069888 | Intelligent medical device system for personalized medicine applications - The system presents applications of personalized medicine with intelligent medical devices (iMDs) and customizes therapies to complex problems involving neurological, cardiovascular, cancer, immunological and endocrinological diseases. | 03-18-2010 |
| 20100069889 | Intelligent medical device system for integrated diagnostics and therapeutics - The system integrates medical diagnostics with therapeutics in an intelligent medical device (iMD) system. Solution options are generated and evaluated by the iMD's diagnostic module, which forwards a custom solution to the therapeutics module. The therapeutics module administers a customized combination of drugs to solve a specific set of pathologies on demand. The system automatically monitors the therapeutic operation, assesses and analyzes the biological system feedback, refines the drug combination, and delivers the refined drugs to the patient. | 03-18-2010 |
| 20100069890 | USER INTERFACE FOR MEDICAL SYSTEM COMPRISING DIARY FUNCTION WITH TIME CHANGE FEATURE - The invention provides a device for displaying information, comprising display means adapted to graphically display information as a function of time for a given period of time, and input means for changing the time from a first time setting to a second time setting, thereby generating an end of time value for the first setting and a start of time value for the second time setting. The display means is controlled to display a first and a second view, the first view displaying, for the given period of time, information corresponding to the first time setting until the end of time value, the second view displaying, for the given period of time, information corresponding to the second time setting from the start of time value. In the first view the period between the end of time value and the end of the given period is indicated as not comprising information as a function of time, and in the second view the period between the beginning of the given period and the start of time value is indicated as not comprising information as a function of time. By this arrangement a user interface is provided reducing the likelihood that graphically displayed information is misinterpreted in case of a time change event. | 03-18-2010 |
| 20100076412 | Method and System for Providing Integrated Medication Infusion and Analyte Monitoring System - Method and system for integrating infusion device and analyte monitoring system including medication infusion device such as an insulin pump and an analyte monitoring system such as a glucose monitoring system are provided. | 03-25-2010 |
| 20100094261 | SYSTEM AND METHOD FOR ADMINISTERING AN INFUSIBLE FLUID - A method, computer program product, and infusion pump assembly for administering a sequential, multi-part, infusion event, wherein the sequential, multi-part, infusion event includes a plurality of discrete infusion events. If a one-time infusion event is available to be administered, the administration of at least a portion of the plurality of discrete infusion events included within the sequential, multi-part, infusion event is delayed. The one-time infusion event is administered. | 04-15-2010 |
| 20100100076 | Method and System for Providing Integrated Medication Infusion and Analyte Monitoring System - Method and system for integrating infusion device and analyte monitoring system including medication infusion device such as an insulin pump and an analyte monitoring system such as a glucose monitoring system are provided. | 04-22-2010 |
| 20100100077 | Method and System for Providing Integrated Medication Infusion and Analyte Monitoring System - Method and system for integrating infusion device and analyte monitoring system including medication infusion device such as an insulin pump and an analyte monitoring system such as a glucose monitoring system are provided. | 04-22-2010 |
| 20100100078 | Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor. | 04-22-2010 |
| 20100114072 | HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE - The invention relates to a transducer device ( | 05-06-2010 |
| 20100114073 | Device and Method Employing Shape Memory Alloy - A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system. | 05-06-2010 |
| 20100121314 | REGULATED DRUG DELIVERY SYSTEM - A drug delivery device for regulating delivery of a drug to a patient ( | 05-13-2010 |
| 20100121315 | PERSONAL ACCESSORY FOR USE WITH A PILL - A wearable accessory controls ( | 05-13-2010 |
| 20100137842 | Ambulatory Infusion Devices With Improved Delivery Accuracy - Infusion devices that are configured to measure fluid flow and to adjust delivery. | 06-03-2010 |
| 20100145316 | DEVICE FOR DELIVERY OF A SUBSTANCE - A device for delivering a substance in situ in a body comprising at least one permeable expandable container having a first dimension and a second dimension and having contained therein the substance to be delivered; and at least one expandable particle comprising a swellable material contained within the container and capable of expanding when contacted with a fluid; whereby when the device is positioned in situ, bodily fluid permeates the container causing the at least one expandable particle contained therein to swell and the container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance is provided. | 06-10-2010 |
| 20100198196 | Therapy Delivery Device Programming Tool - Methods and devices for providing programming tool for programming the initial and on-going operation of a therapy delivery device is provided. Embodiments include generating empirical rules for determining initial operating settings, applying the final empirical rules to a patient population, detecting a connection to a therapy delivery device, identifying the connected delivery device, receiving data download request from the delivery device. retrieving updated data associated with the connected delivery device; visualizing changes to the settings data of the device, and automatically transmitting the retrieved updated data to the delivery device. | 08-05-2010 |
| 20100217238 | Computerized System for Blood Chemistry Monitoring - An apparatus and computerized method of intravenously monitoring a patient's blood chemistry transmits real time measurements to an electronically controlled closed loop system that auto-regulates blood osmolality and glucose level with medications infused through a catheter designed for such purpose. The closed loop system utilizes a glucose algorithm and an osmolality algorithm implemented in hardware and software to control the flow of dextrose, insulin and hypertonic saline to a patient in an effort to achieve better patient outcomes in instances of trauma, surgery and medical illnesses. | 08-26-2010 |
| 20100234830 | Medical Device for Glucose Monitoring or Regulation - A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration. | 09-16-2010 |
| 20100249756 | SYSTEM AND METHOD FOR MONITORING CARDIOPULMONARY FLUID TRANSFER RATES USING AN IMPLANTABLE MEDICAL DEVICE - Techniques are provided for use by a pacemaker or other implantable medical device for detecting and tracking trends in cardiopulmonary fluid transfer rates—such as heart-to-lung fluid perfusion rates and lung-to-lymphatic system fluid excretion rates—and for detecting heart failure, dyspnea or other cardiopulmonary conditions. In one example, the device periodically measures transthoracic admittance values. A first exponential time-constant (k | 09-30-2010 |
| 20100249757 | Method of Electrogenically Controlling Pump Molecules - Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example in a physiological operating mode by applying the concept of an electronic synchrotron to the biological system. It was shown that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiometric number of the pump molecules. | 09-30-2010 |
| 20100280499 | SYSTEM AND METHOD FOR GLYCEMIC CONTROL - Disclosed is a glucose monitoring system. The system includes a glucose sensor to periodically perform a plurality of glucose measurements in interstitial fluid, and a processor to determine one or more HbA1c values representative of a patient's glycosylated hemoglobin levels based on the periodic glucose measurements. In some embodiments, the glucose sensor is coupled to a therapeutic fluid (e.g., insulin) dispensing pump. | 11-04-2010 |
| 20100298815 | MEDICAL IMPLANTS WITH RESERVOIR(S), AND MATERIALS PREPARABLE FROM SAME - Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients. | 11-25-2010 |
| 20100312228 | INGESTIBLE THERAPY ACTIVATOR SYSTEM AND METHOD - An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The responder module may receive and process the effector instruction, resulting in a response by the therapeutic device. Examples of responses by therapeutic device include activating a therapy, deactivating a therapy, modulating a therapy, and discontinuing a therapy. | 12-09-2010 |
| 20100331826 | APPARATUS FOR INFUSING LIQUID TO A BODY - An infusion device having a housing with a reusable control portion and an expendable reservoir portion includes a precise drive for an infusion pump. The drive includes a piezoelectric bender assembly, a limiter and at least one contact stop. The piezoelectric bender assembly includes a cantilevered piezoelectric bender having an member of predetermined thickness fixed to move with the second end. A limiter of dimensionally stable material including a gap and at least a first mounting hole extending to the gap. The member of predetermined thickness extends into the gap. A first contact stop is positioned in the gap to define a critical gap distance limiting movement of the member of predetermined thickness in the gap. A base has a mounting surface, a port through the base and extending to the mounting surface. The port includes a first length having a smaller diameter at the mounting surface and a second length displaced from the mounting surface and having a larger diameter. A rigid cannula extends from the base through the port. The rigid cannula has a diameter smaller than the smaller diameter of the port, and the first length of the port has an annular open gap for lateral or pivotal movement of the rigid cannula. A mount of elastomeric material in the length having the larger diameter mounts the rigid cannula. The cannula includes hydrogel material in a desiccated state coating the surface of the cannula, including the beveled end, which rehydrates upon placement in the patient. | 12-30-2010 |
| 20100331827 | ADMINISTRATION OF DRUGS TO A PATIENT - The invention relates to a method and an electronic pill ( | 12-30-2010 |
| 20110028945 | Device including altered microorganisms, and methods and systems of use - Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent. | 02-03-2011 |
| 20110066141 | IMPLANTABLE MEDICAL DEVICE HAVING AN ANTI-GASTRIC DISTRESS AGENT - Medical devices, and methods of use therewith, suitable for at least partial implantation within the gastrointestinal portions of a body and having at least one anti-gastric distress agent are provided. The anti-gastric distress agent can include antacids, H2 blockers, proton pump inhibitors, or any combination thereof. The medical device can also include one or more sections having one or more anti-gastric distress agent or antimicrobial agents. The medical device has a length such that when the device is at least partially implanted the first section is accessible to the gastrointestinal portion of the patient's body. A second section having an antimicrobial agent may be external to the gastrointestinal portion. Preferably, device includes a first and second anti-gastric distress agent each having a different controlled release rate. The therapeutic agents can be disposed on one or more surfaces of the medical device and/or impregnated with the material of the medical device. | 03-17-2011 |
| 20110082445 | ADMINISTRATION DEVICE HAVING PATIENT STATE MONITOR - Embodiments disclosed herein include systems and methods for administering a drug over a time period. One embodiment of a system includes an administration unit, a housing that houses the administration unit, and a controller unit adapted to receive an alarm triggering signal. Also included in some embodiments is an alarming unit that is adapted to generate an alarm signal on reception of the alarm triggering signal. Some embodiments include a patient state monitor that includes a motion-sensitive sensor unit that is reactive on patient motion. The patient state monitor may be adapted to process a sensor signal generated by the motion-sensitive sensor unit. The patient state monitor may also be adapted to transmit an alarm triggering signal to the controller unit if a patient motion level is below a predefined motion level, as determined by the length of time without patient motion. | 04-07-2011 |
| 20110092959 | ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS - Electronic pill ( | 04-21-2011 |
| 20110098685 | METHODS FOR PRODUCTION AND USE OF SUBSTANCE-LOADED ERYTHROCYTES (S-IEs) FOR OBSERVATION AND TREATMENT OF MICROVASCULAR HEMODYNAMICS - Disclosed herein are methods, kits, and compositions for medical imaging relating to fluorescent dyes entrapped in erythrocytes. Also disclosed therein are methods, and compositions further comprising erythrocytes entrapping at least one therapeutically active agent, as well as methods for releasing the entrapped therapeutically active agent(s). Disclosed herein also are methods for preparation of the cells entrapping dye and therapeutically active agent(s) in a freeze-dried form that makes them readily available and easy to use in a clinical environment. | 04-28-2011 |
| 20110098686 | Reservoir Device for Intraocular Drug Delivery - A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient. | 04-28-2011 |
| 20110106062 | System and Method For In Vivo Delivery of Antibodies and Fragments Thereof - The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suffering for a neurodegenerative disorder or other diseases treated by antibody administration. | 05-05-2011 |
| 20110106063 | ELECTRONIC PILL COMPRISING A MEDICINE RESERVOIR - Electronic pill ( | 05-05-2011 |
| 20110118705 | SENSOR AND CONTROL UNIT FOR FLOW CONTROL AND A METHOD FOR CONTROLLED DELIVERY OF FLUID - The invention relates to a sensor ( | 05-19-2011 |
| 20110125136 | INTRAVASCULAR DIAGNOSTIC AND THERAPEUTIC SAMPLING DEVICE - A device and methods for continuous precision blood sampling from a patient with a micro impedance pump as the driver in a microfluidic system. Depending on the needs of medical technologies, the micro impedance pump in the intravascular diagnostic and therapeutic sampling system serves in a forward pumping function for blood sampling, in a backward infusing for therapeutic treatment, and in a valving function for controlling fluid flow. | 05-26-2011 |
| 20110130746 | SAFETY LAYER FOR INTEGRATED INSULIN DELIVERY SYSTEM - An integrated diabetes management (IDM) system includes a safety layer which, in one configuration has two components, one located between a glucose sensor and a controller and a second component located between a controller and a pump, to monitor various aspects of signals and modify those signals for compatibility and safety purposes. In one application, the safety layer receives output control signals from a controller and modifies those control signals as a function of an actual amount of insulin delivered to the user. The safety layer allows for an increased level of safety in the IDM system and permits development of separate hardware and software upgrades with the safety layer assuring that compatibility between components will continue. | 06-02-2011 |
| 20110137297 | PHARMACOLOGICAL MANAGEMENT SYSTEM - A pharmacological management system has sensors, a pharmacological status monitor and a drug administrator. The sensors attach to the patient so as to generate corresponding sensor signals. The pharmacological status monitor is responsive to the sensor signals so as to generate an output indicative of the drug-induced effects of the pharmacological agent on the patient. Further, the monitor output is fed-back to the drug administrator so as to regulate administration of the agent for a desired effect. | 06-09-2011 |
| 20110166553 | MEDICAL DEVICE FOR ANALYTE MONITORING AND DRUG DELIVERY - The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device. | 07-07-2011 |
| 20110172645 | WEARABLE DRUG DELIVERY DEVICE INCLUDING INTEGRATED PUMPING AND ACTIVATION ELEMENTS - A drug delivery device for delivering a drug to a subject is provided. The drug delivery device includes a housing, a drug reservoir supported by the housing containing the drug and a hollow microneedle supported by the housing. The hollow microneedle is moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle. The channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle. The channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position. | 07-14-2011 |
| 20110184387 | Compositions and methods for therapeutic delivery with microorganisms - Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent. | 07-28-2011 |
| 20110196347 | MEDICAL DEVICES EMPLOYING PIEZOELECTRIC MATERIALS FOR DELIVERY OF THERAPEUTIC AGENTS - In one aspect, the present invention provides therapeutic-agent-releasing medical devices which comprise at least one region of piezoelectric material. Therapeutic agent release is initiated or increased when the piezoelectric material is subjected to mechanical stress, which leads to the development of a voltage across the piezoelectric material. This voltage is used to initiate or increase therapeutic agent release. | 08-11-2011 |
| 20110202040 | ADMINISTRATION DEVICE HAVING A BOLUS ADMINISTRATION PROFILE CONTROLLER - According to one embodiment, an administration device for subcutaneous administration of a liquid drug over an extended period of time is provided. The administration device may include an administration unit, a housing, and a controller unit. The administration unit may include a drug reservoir and a pump unit. The housing may include the administration unit and may be adapted to be carried by a patient over an extend period of time. The controller unit may include a bolus administration profile controller. The bolus administration profile controller receives a bolus volume of a bolus to be administered and determines based, at least in part, on the bolus volume a bolus administration profile such that a depot volume of a depot is limited. | 08-18-2011 |
| 20110257632 | DEVICE FOR ADMINISTERING LIQUID ANALGESICS - In the field of pain relief and treatment there is a need for a device which is able to administer several predetermined doses of an opioid analgesic in a manner which can be done simply and safely by a patient or carer; in particular in a manner which minimises the risk of administering too great a dose at any one time. A device ( | 10-20-2011 |
| 20110282327 | SYSTEM AND METHOD FOR CONTINUOUS NON-INVASIVE GLUCOSE MONITORING - A system and method for continuous non-invasive glucose monitoring is disclosed. According to one embodiment of the present invention, the method includes the steps of (1) contacting a remote device to an area of biological membrane having a permeability level, the remote device comprising a sensor and a transmitter; (2) extracting the at least one analyte through and out of the area of biological membrane and into the sensor; (3) generating an electrical signal representative of a level of the at least one analyte; (4) transmitting the electrical signal to a base device; (5) processing the electrical signal to determine the level of the at least one analyte; and (6) displaying the level of the at least one analyte in real time. The system includes a remote device that includes a sensor that generates an electrical signal representative of the concentration of the at least one analyte; and a transmitter that transmits the electrical signal. The system further includes a base device that includes a receiver that receives the electrical signal; a processor that processes the electrical signal; and a display that displays the processed signal in real time. | 11-17-2011 |
| 20110295241 | METHOD AND APPARATUS FOR IMPROVING LOCAL HYPOXICITY FOR ENHANCED THERAPY - An implantable oxygen generator system is disclosed. The implantable oxygen generator system includes a receiver configured to generate an electrical current, and an electrode set configured to deliver the electrical current to water molecules of an interstitial fluid within a tissue, wherein the electrical current electrolyzes the water molecules into oxygen molecules. | 12-01-2011 |
| 20120010599 | INORGANICALLY SURFACE-MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics. | 01-12-2012 |
| 20120010600 | METHOD OF OVERNIGHT CLOSED-LOOP INSULIN DELIVERY WITH MODEL PREDICTIVE CONTROL AND GLUCOSE MEASUREMENT ERROR MODEL - A closed-loop method for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery. | 01-12-2012 |
| 20120083767 | IMPLANTABLE BIOREACTOR FOR DELIVERY OF PARACRINE FACTORS - An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation. | 04-05-2012 |
| 20120150153 | Method and System for Monitoring Nutritional Uptake as a Function of Microflora Intestinal Gas Levels - Systems and methods for monitoring nutritional uptake of an individual are disclosed. The method can include monitoring microflora intestinal gas concentration levels associated with a patient and adjusting the volume of nutrient provided by the patient with an artificial feeding device based at least in part on the microflora intestinal gas levels associated with the patient. A microflora intestinal gas sensor can be used to monitor the microflora intestinal gas associated with the patient. The microflora intestinal gas sensor can monitor the microflora intestinal gas in a patient's exhaled breath or in the patient's digestive tract. The microflora intestinal gas sensor be included as part of an enteral feeding system at the distal end or outside end of an enteral feeding tube. Systems and methods for monitoring nutritional uptake of an infant based on microflora intestinal gas levels associated with the infant are also disclosed. | 06-14-2012 |
| 20120165792 | Pill Catchers - Devices and related methods arc provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete. administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs. | 06-28-2012 |
| 20120165793 | Pill Catchers - Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs. | 06-28-2012 |
| 20120165794 | Pill Catchers - Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs. | 06-28-2012 |
| 20120165795 | THERAPEUTIC AGENT RESERVOIR DELIVERY SYSTEM - A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane. | 06-28-2012 |
| 20120330281 | Device, system, and method including micro-patterned cell treatment array - Devices, systems, or methods are disclosed herein for treatment of disease in a vertebrate subject. The device can include a quasi-planar substrate; and one or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the one or more laterally-mobile effector molecule types is configured to interact with one or more cell types. The device can further include one or more sensors configured to detect at least one aspect of an interaction between the at least one of the one or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the one or more laterally-mobile effector molecule types, the quasi-planar substrate, and the one or more cell types. | 12-27-2012 |
| 20130165906 | ADMINISTRATION APPARATUS, OPERATING METHOD THEREOF AND ADMINISTRATION METHOD - An administration apparatus to administer an inhibitor drug to a patient to inhibit cell division of a malignant cell includes an administration unit configured to administer the inhibitor drug to the patient; an administration timing storage unit configured to store an administration time to start an administration of the inhibitor drug; a time measurement unit configured to measure a current time; and a control unit configured to drive and control the administration unit so as to administer the inhibitor drug to the patient when the current time coincides with the administration time. The administration time is set on a basis of a pre-determined phase of a cell cycle of the malignant cell. | 06-27-2013 |
| 20130231642 | Maintaining Multiple Defined Physiological Zones Using Model Predictive Control - The disclosure relates to drug delivery and maintaining multiple defined physiological zones using model predictive control. | 09-05-2013 |
| 20130338645 | TRANSDERMAL DRUG DELIVERY METHOD AND SYSTEM - The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated. | 12-19-2013 |
| 20140180262 | IMPLANTABLE MEDICAL DEVICE FOR MINIMALLY-INVASIVE INSERTION - Containment devices and methods of manufacture and assembly are provided. In an embodiment, the containment device includes an elongated microchip element comprising one or more containment reservoirs that are configured to be electrically activated to open. The containment device also include an elongated electronic printed circuit board (PCB) comprising a substrate. The elongated PCB comprises a first side on which one or more electronic components are fixed and an opposed second side on which the elongated microchip element is fixed in electrical connection to the one or more electronic components. Further, the containment device includes an elongated housing fixed to the elongated PCB. The elongated housing is configured to hermetically seal the one or more electronic components of the elongated PCB within the elongated housing. | 06-26-2014 |
| 20140257251 | CUSTOMIZING NAMES OF INSULIN DELIVERY PROFILES FOR IMPROVED PATIENT SAFETY - Configuration software implements techniques for customizing names of insulin delivery profiles with improved patient safety. The techniques include: receiving a string of characters which serve as a name for a given insulin delivery profile, where the insulin delivery profile includes at least one parameter pertaining to insulin delivery by an insulin pump and is one of a plurality of insulin delivery profiles associated with a given patient; normalizing the string of characters in accordance with a rule set; comparing the normalized string of characters with names for each of the plurality of insulin delivery profiles; and updating the name of the given insulin delivery profile in a pump configuration file residing on the configuration device when the normalized string of characters is unique in relation to the names of the plurality of insulin delivery profiles. | 09-11-2014 |
| 20140276664 | IMPLANTABLE MEDICAL DEVICE HAVING CLOCK TREE NETWORK WITH REDUCED POWER CONSUMPTION - An integrated circuit includes a clock tree network that distributes a clock signal to a plurality of clocked components of the integrated circuit. The clock tree network includes clock lines, each of which includes a clock tree delay element that provides a modified clock signal that is provided to an individual one the clocked components. Among the plurality of clocked components, one or more of the clocked components provides a data signal to another one or more of the clocked components. The one or more clocked components are configured having a transmission duration for the data signal that is longer relative to a transmission duration of the modified clock signal of the receiving clocked component. | 09-18-2014 |
| 20140350528 | SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT - Devices and methods for delivering a fluid to a patient are disclosed herein. In one embodiment, a method includes providing a wearable delivery device that includes an electrochemical actuator and a reservoir containing a fluid with viscosity greater than 15 cP. The electrochemical actuator can be actuated such that the actuator exerts sufficient force on the reservoir to cause the fluid within the reservoir to be communicated to the patient's body over a time period. In some embodiments, the time period is two hours. In one embodiment, a delivery system includes a reservoir containing a fluid having a viscosity greater than 15 cP and a fluid communicator in fluid communication with the reservoir. An electrochemical actuator is coupled to the reservoir and configured to exert a sufficient force on the reservoir for a time period upon actuation such that the fluid within the reservoir is communicated through the fluid communicator. | 11-27-2014 |
| 20140358128 | SURFACE PLASMON RESONANT DEVICES AND METHODS OF USE THEREOF - Devices and methods are provided for controlling the propagation of electromagnetic radiation on conductive surfaces via the presence of coupled subwavelength conductor-dielectric unit plasmonic resonators. In some embodiments, the dimensions of the unit plasmonic resonators are selected to produce modal overlap and coupling between surface plasmons of adjacent conductive surfaces. The properties of the unit plasmonic resonators may be spatially graded to produce the slowing down and/or trapping of electromagnetic waves. Methods are provided for calculating resonant modes of structures that involve intra-resonator plasmonic coupling. Various example implementations of such devices and structures are provided. | 12-04-2014 |
| 20150073393 | COORDINATION OF CONTROL COMMANDS AND CONTROLLER DISABLE MESSAGES IN A MEDICAL DEVICE SYSTEM - A medical device system includes at least one controllable patient-worn or patient-carried medical device, and a plurality of controller devices that are capable of independently controlling features or functions of the patient medical device. Control commands and other data is wirelessly communicated among the patient medical device and the multiple controller devices. A number of techniques, protocols, and other measures are provided to coordinate wireless communication between the various devices in a medical device system. These control command coordination processes address situations where conflicting, redundant, or concurrent control commands might be independently issued by the multiple controller devices. | 03-12-2015 |
| 20150112315 | CONTROLLING ACCESS TO AN INTRAVENOUS CATHETER - A system includes an intravenous catheter having a catheter chamber, a catheter line for insertion into a blood vessel of the identified patient, and an electronically actuatable blocking member providing selective fluid communication between the catheter chamber and the catheter line. A reader is secured to the catheter chamber for reading an identification code that identifies a liquid in a syringe received within the catheter chamber. A control system accesses an electronic patient record that includes medical information specific to an identified patient and runs an application program logically associating the intravenous catheter and the medical information specific to the identified patient, determining whether the administration of the identified liquid to the identified patient is compatible within the medical information specific to the identified patient, and controlling electronic actuation of the blocking member. | 04-23-2015 |
| 20150112316 | CONTROLLING ACCESS TO AN INTRAVENOUS CATHETER - A method includes logically associating an intravenous catheter and an electronic patient record stored on a computer readable storage medium, wherein the electronic patient record includes medical information specific to an identified patient. An identification code of a syringe to be administered to the identified patient is read in order to identify a liquid contained in the syringe. The blocking member may be electronically actuated to provide fluid communication between a catheter chamber and a catheter line inserted into the identified patient, wherein the fluid communication is provided only while the syringe is received within the catheter chamber and only in response to determining that administration of the identified liquid to the identified patient is compatible within the medical information. | 04-23-2015 |
| 20150141967 | Electronic Pill for Delivery of Powder Medication - The invention relates to an electronic pill ( | 05-21-2015 |
| 20150342875 | IMPLANTS WITH CONTROLLED DRUG DELIVERY FEATURES AND METHODS OF USING SAME - Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device. | 12-03-2015 |
| 20160030721 | DEVICE, SYSTEM, AND METHOD FOR DELIVERY OF SUGAR GLASS STABILIZED COMPOSITIONS - Devices, methods, and compositions are described that includes an implantable device including one or more compartments. One or more pharmaceutically effective compounds stabilized in a sugar glass composition, at least one of the one or more stabilized pharmaceutically effective compounds in the sugar glass composition enclosed within the one or more compartments; and one or more reservoirs configured to provide access for one or more release agents to an interior of the sugar glass composition, wherein the one or more reservoirs are configured to controllably dispense the one or more release agents to disrupt the sugar glass composition from the interior of the sugar glass composition. | 02-04-2016 |
| 20160058942 | SYSTEM AND METHOD FOR ADMINISTERING AN INFUSIBLE FLUID - A method, computer program product, and infusion pump assembly for administering a sequential, multi-part, infusion event, wherein the sequential, multi-part, infusion event includes a plurality of discrete infusion events. If a one-time infusion event is available to be administered, the administration of at least a portion of the plurality of discrete infusion events included within the sequential, multi-part, infusion event is delayed. The one-time infusion event is administered. | 03-03-2016 |
| 20160114104 | MEDICAMENT INFUSION SYSTEM AND METHODS OF USE THEREOF - A medicament infusion system and methods of use thereof are disclosed herein for delivery of a medicament from a medicament source reservoir to a patient recipient. A medicament infusion system is disclosed that includes: a cylindrical tubing member having a medicament source connector configured to connect to a medicament source reservoir and a patient recipient connector configured to connect to a patient recipient; a medicament data transmitter operably connected to transmit medicament source data to the medicament source connector; a communication connection embedded within the wall of the cylindrical tubing member to transmit medicament source data from the medicament source connector to the patient recipient connector; a wireless tag operably connected to communicate with the patient recipient connector, the wireless tag configured to transmit the medicament source data; and a controller including circuitry to determine a connection status between the medicament source connector and the patient recipient connector. | 04-28-2016 |
| 20160136401 | HELICAL COIL DELIVERY DEVICE FOR ACTIVE AGENT - A delivery device including a substrate formed in a coil comprising a plurality of loops, an active agent deposited between an inner surface and an outer surface of the substrate formed in the coil, and a pair of end caps, each end cap disposed on a corresponding end of the coil. | 05-19-2016 |
