Class / Patent application number | Description | Number of patent applications / Date published |
600002000 | Combined with other radiant or wave energy source (e.g., electromagnetic, thermal, microwave etc.) | 39 |
20080221382 | Method and system of radiotherapy enhancement through cellular perturbation using ultrasound and microbubbles - An embodiment of the invention is related to a system for providing radiotherapy to a treatment region. The system includes a radiation source and a sound source. The radiation source is positioned to irradiate the treatment region. The sound source is positioned to provide ultrasound to the treatment region so that the treatment region is subject to coincidental treatment by irradiation and ultrasound. | 09-11-2008 |
20080234531 | BI-POLAR TREATMENT FACILITY FOR TREATING TARGET CELLS WITH BOTH POSITIVE AND NEGATIVE IONS - A system for treating target cells with both positive and negative ions comprises a bi-polar beam delivery system configured to create and deliver both positive ion beams and negative ion beams. The bi-polar beam delivery system comprises a bi-polar accelerator configured to accelerate positive and negative ions in the same direction making such a bi-polar bema delivery system practical. | 09-25-2008 |
20080287728 | MARKER SYSTEMS AND METHODS OF USING THE SAME - A marker system includes a structure having a first surface and a second surface, a first marker located on the first surface, and a second marker located on the second surface, wherein the first marker and the second marker are arranged so that they face approximately a same direction, and so that they can be simultaneously viewed by an optical device, and wherein a first distance between the first marker and the optical device is different from a second distance between the second marker and the optical device when the first and the second markers are simultaneously viewed by the optical device. | 11-20-2008 |
20090054720 | Use of histone deacetylase inhibitors in combination with radiation for the treatment of cancer - The present invention relates to a method for the treatment of cancer in a patient in need thereof. The method comprises administering to a patient in need thereof a first amount of a histone deacetylase inhibitor in a first treatment procedure, and a second amount or dose of radiation in a second treatment procedure. The first and second treatments together comprise a therapeutically effective amount. The combination of the HDAC inhibitor and radiation therapy is therapeutically synergistic. | 02-26-2009 |
20090069624 | STABILIZER AND METHOD FOR IRRADIATING TUMORS - A method of treating a region of diseased tissue using a probe is disclosed. A probe cannula is introduced into the tissue of the patient until a distal end of the cannula is located at or proximate to the treatment region. A plurality of electrodes are then deployed from the distal end of the cannula into the treatment region. Energy (e.g., radiofrequency energy) is then delivered through the plurality of electrodes to the tissue. The cannula is then secured to an immobile object external to the patient. The treatment region is irradiated with a therapeutically effective dose of an ionizing radiation while the plurality of electrodes remain at least partially advanced within the treatment region and while the cannula remains secured to the immobile object. | 03-12-2009 |
20090198093 | System and method for combined embolization and ablation therapy - A system and method of treating cancerous tissues using a combination of embolization and ablation therapies is described. An imaging device is used to determine the tissue volume to be treated, and the steps of embolization and ablation are performed while the patient remains on a treatment table. The embolization treatment may be combined with chemotherapy directly administered to the tumor. The position of the volume to be treated is visualized by the imaging device to monitor the progress of the treatment and to guide ablation treatment so as to mitigate collateral tissue damage. The imaging device may be a C-arm X-ray device, a MRI device, an acoustic device or other device capable of producing CT-like images. | 08-06-2009 |
20100076246 | Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease - New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles. | 03-25-2010 |
20110034752 | THERAPEUTIC REGIMEN FOR TREATING CANCER - The invention provides a method for treating cancer in a human comprising (a) administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding a human TNF-α and operably linked to a promoter, wherein the dose comprises about 4×10 | 02-10-2011 |
20110124947 | METHOD FOR INTEGRATING LARGE SCALE BIOLOGICAL DATA WITH IMAGING - Methods for extracting large scale biological, biochemical or molecular information about an index disease, biological state, or systems from imaging by correlating the imaging features associated with said disease, state or system with corresponding large scale biological data. | 05-26-2011 |
20110144410 | Therapy Device and Related Accessories, Compositions, and Treatment Methods - The invention is directed to a therapy device, including a body, an energy source disposed on the body for emitting a desired wavelength of electromagnetic radiation, and a material dispensing system disposed on the body for dispensing a desired material for use with the device. Also disclosed are accessories and compositions used with the therapy device, including interchangeable energy source-containing heads and interchangeable material containers. Methods for using the therapy device are also disclosed. | 06-16-2011 |
20110160514 | ELECTRICAL ABLATION DEVICES - A variety of electrical ablation apparatuses and methods are disclosed. In one embodiment, an ablation apparatus includes an injector catheter electrode having a proximal end configured to couple to an energy source and a fluid source. A distal end of the injector catheter defines an injection needle and defines an electrically conductive hollow channel for communicating a fluid from the fluid source to a treatment site. A balloon electrode is in fluid communication with a balloon catheter. The balloon catheter has a proximal end configured to couple to the energy source and the fluid source and a distal end configured to inflate the balloon electrode. | 06-30-2011 |
20110224477 | THERAPEUTIC DEVICE COMBINING RADIATION THERAPY AND THERMOTHERAPY - The disclosure relates to a therapeutic device for treatment of a patient, particularly for cancer treatment, which includes a radiation therapy apparatus for applying an ionizing radiation to the patient, and an integrated thermotherapeutic heating device for inducing a regional hyperthermia in the patient. | 09-15-2011 |
20110301401 | COMPOSITIONS AND METHODS FOR THERMORADIOTHERAPY - The present invention relates to compositions and methods for increasing tissue-radiosensitivity through induction of local hyperthermia. In particular, the present invention provides superparamagnetic, paramagnetic, or ferromagnetic radioactive particles that heat surrounding tissue upon magnetic induction, and methods of use thereof. In some embodiments, the present invention provides compositions and methods for thermoradiotherapy (e.g. anti-tumor therapy). | 12-08-2011 |
20120016174 | DEVICE AND METHOD FOR PROVIDING A SYNERGISTIC COMBINATION OF PHOTOTHERAPY AND A NON-LIGHT ENERGY MODALITY TO THE BRAIN - Systems and methods that could reduce the potential for side effects while delivering a reduced amount of light energy and non-light energy to a patient while providing a desired therapeutic effect that might otherwise only be achievable with a higher dose of either the light energy or non-light energy administered alone are disclosed. In certain embodiments, disclosed is a system and method for treating a patient, by administering a combination of light therapy from a light energy source in addition to one, two, or more other non-light energy modalities to a target region of a patient for a synergistic therapeutic effect. | 01-19-2012 |
20120197061 | MAGNETIC COMPRESSION DELIVERY DEVICES AND RELATED DEVICES AND METHODS - Catheters configured to deliver magnets for magnetic compression of target tissue have at least one deflatable or retractable tissue spacer and/or radioactive material on the magnet. | 08-02-2012 |
20120209051 | METHOD AND APPARATUS FOR THE DELIVERY OF PHOTOCHEMICAL (CROSS-LINKING) TREATMENT TO SCLERAL TISSUE - Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue. | 08-16-2012 |
20120220812 | ULTRASOUND NEUROMODULATION FOR STROKE MITIGATION AND REHABILITATION - Disclosed are methods and systems and methods for neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke. The neuromodulation can produce acute effects or result in Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, firing pattern, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for mitigating the effects of stroke and/or in stroke rehabilitation. | 08-30-2012 |
20120253098 | PULSED ELECTROMAGNETIC ENERGY TREATMENT APPARATUS AND METHOD - An apparatus and method for the treatment of chronic wounds using electromagnetic energy. The apparatus includes a generator and at least one applicator. The generator can produce electromagnetic energy and the applicator can apply the electromagnetic energy produced by the generator. A detector is disposed on the applicator that can measure the field strength of the electromagnetic energy applied. | 10-04-2012 |
20120277517 | Formulation and Methods for Enhanced Interventional Image-Guided Therapy of Cancer - An embodiment in accordance with the present invention provides a thermo-chemoembolization formulation and method for enhanced interventional image-guided therapy for cancer. The T-C formulation includes magnetic iron oxide nano-particles (MIONs) that heat when exposed to an alternating magnetic field (AMF), a liquid tumorphilic drug carrier that enhances tumor retention of the T-C formulation, and a chemotherapeutic or radiotherapeutic agent. The T-C formulation enhances delivery of heat and chemo- or radio-therapeutic agents with hyperthermia produced by magnetic nanoparticles to improve therapeutic outcomes. The magnetic nanoparticles and tumorphilic drug carrier also allow for multimodal image-guided monitoring of treatment and patient follow-up. The method for enhanced interventional image-guided therapy for cancer includes using an AMF to heat the T-C formulation and activate the thermotherapy. | 11-01-2012 |
20120283502 | ULTRASOUND NEUROMODULATION TREATMENT OF DEPRESSION AND BIPOLAR DISORDER - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat depression, bipolar disorder, and other mood disorders. Also disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to affect the mood or emotional state of a subject or user. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Potentiation (LTP) or Long-Term Depression (LTD) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 11-08-2012 |
20120283503 | NANOPARTICLE LOADED STEM CELLS AND THEIR USE IN MRI GUIDED HYPERTHERMIA - The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions. The heating of diseased tissue either results in direct cell killing or makes the tumor more susceptible to radio- and/or chemotherapy. The NLSC of the present invention can be used for MR image-guided hyperthermia in oncology, in stem cell research for cell tracking and heating, and for elimination of mis-injected stem cells. | 11-08-2012 |
20120289761 | Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject - Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject. | 11-15-2012 |
20130012755 | SYSTEMS AND METHODS FOR ACCELERATING HEALING OF IMPLANTED MATERIAL AND/OR NATIVE TISSUE - Various embodiments provide methods and systems for ultrasound treatment of tissue are provided. Accordingly, a method can include locating an implant in a site in a body, directing a medicant to at least one of the implant and the site, directing ultrasound energy to the site, and accelerating healing of the implant and/or native tissue at the site. | 01-10-2013 |
20130053618 | RADIATION SENSITIVE LIPOSOMES - The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents. | 02-28-2013 |
20130131432 | Selective Destruction of Cancer Cells via Tuned Ultrasound Resonance - Disclosed is a method to use tuned resonant frequency ultrasonic energy for treatment of cancer that selectively destroys neoplastic cells while leaving surrounding healthy tissue minimally affected. | 05-23-2013 |
20130131433 | THERAPEUTIC APPARATUS - The invention provides for a therapeutic apparatus comprising a tissue heating system ( | 05-23-2013 |
20130197295 | TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY - Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heat energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy. | 08-01-2013 |
20130261371 | IMAGEABLE ACTIVATABLE AGENT FOR RADIATION THERAPY AND METHOD AND SYSTEM FOR RADIATION THERAPY - Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules. | 10-03-2013 |
20130317276 | BRACHYTHERAPY TANDEM AND OVOID IMPLANTATION DEVICES AND METHODS - Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section retained within a body cavity during and between radiation treatments. This can be for single-patient use and disposed of after completion of a multiple-dose radiation treatment session. Real time in vivo detection and monitoring and hytpertherapy features can be included. Tandem or ovoid colpostats can feature bendability to tailor the system to the specific body and patient being treated. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from chosen body sites. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats. | 11-28-2013 |
20140018605 | SELECTIVE LUNG TISSUE ABLATION - Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue. | 01-16-2014 |
20140094643 | Controlling Particle Therapy - An example particle therapy system includes the following: a gantry that is rotatable relative to a patient position; a particle accelerator mounted to the gantry, where the particle accelerator is for outputting a particle beam essentially directly to the patient position; and a control system to receive a prescription and to generate machine instructions for configuring one or more operational characteristics of the particle therapy system. At least one of the operational characteristics relates to a rotational angle of the gantry relative to the patient position. | 04-03-2014 |
20140163303 | PLASMONIC ASSISTED SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE - A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent. | 06-12-2014 |
20140257013 | BRACHYTHERAPY DEVICES AND METHODS FOR THERAPEUTIC RADIATION PROCEDURES - Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one balloon that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member. | 09-11-2014 |
20140275712 | RADIATION TREATMENT SHEET DEVICES AND METHODS - Radiation therapy devices, systems and methods are in general sheet-like form, are characterized by flexibility, and include at least one spacer that can be a balloon or bubble that assists in placement of radio therapeutic members at desired treatment locations along or around a limb, within an existing body cavity, or at a site that was formed under a patient's skin for treatment purposes. Sarcoma treatment is particularly conducive to treatment by these devices, systems and methods. One or more detectors, such as microdiodes, are accommodated when desired on the device, and a hyperthermia tube or the like is also includable that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member. | 09-18-2014 |
20140378738 | IRRADIATION SYSTEM - An irradiation system for simultaneous application of radiation therapy and hyperthermia is provided. The irradiation system has a radiation source and a magnetic resonance tomography apparatus comprising a controller, a plurality of local coils for arrangement on the body of a patient, and a plurality of transmission devices. The transmission devices are configured to supply the local coils with radiofrequency signals independently of one another. In this case, the controller is configured to actuate the transmission devices in such a way that a predetermined region in the body of the patient is heated to a predetermined temperature by means of the radiofrequency signals emitted by the local coils. The radiation source is configured to irradiate a target in the predetermined region. | 12-25-2014 |
20150065782 | SYSTEMS AND METHODS FOR FORCED NON-UNIFORM RADIOPHARMACEUTICAL UPTAKE - A method is provided including identifying a target portion of a patient corresponding to a portion of interest of the patient to be scanned with a nuclear medicine scanning technique. The method also includes applying an uptake increasing technique to at least one of the target portion or an application portion of the patient other than the target portion. The uptake increasing technique is configured to increase uptake of a radiopharmaceutical to the target portion of the patient relative to portions of the patient other than the target portion. Also, the method includes administering the radiopharmaceutical to the patient temporally proximate to the applying an uptake increasing technique. | 03-05-2015 |
20150141734 | METHOD FOR DETERMINING OPTIMIZED PARAMETERS OF A DEVICE GENERATING A PLURALITY OF ULTRASOUND BEAMS FOCUSED IN A REGION OF INTEREST - The method determines parameters to generate confocal ultrasound beams (B1,B2) inside a medium ( | 05-21-2015 |
20150375010 | BRACHYTHERAPY DEVICES AND METHODS FOR THERAPEUTIC RADIATION PROCEDURES - Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one balloon that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member. | 12-31-2015 |
20160166852 | X-OPTOGENETICS / U-OPTOGENETICS | 06-16-2016 |