| Entries |
| Document | Title | Date |
|---|
| 20080221381 | Recharge Device for Brachytherapy of Tumors - A reloading device for brachytherapy of tumors is to be simplified in terms of the replacement of the radiation source at the irradiation site. At least two tubes are provided for receiving a longitudinally displaceable cable at the end of which a radiation source can be applied. The tubes can be connected, via a source replacement device and a shield, to a removable and adjustable distributor, from which lines lead to the tumor. By adjusting the distributor, the respectively desired line can be oriented to the respectively desired tube and in this way the desired radiation source can be introduced preferably step by step into the tumor. | 09-11-2008 |
| 20080242914 | METHOD AND APPARATUS FOR TREATMENT PLANNING USING IMPLANTED RADIOACTIVE SEEDS - A pre-computed sensitivity function providing ex ante assessment of optimal placement of a single radioactive seed, is used for sequential placement of multiple radioactive seeds. The location of each successive seed may also be constrained by an exclusion function omitting areas in the target receiving a pre-defined dose from the preexisting seeds. This technique makes possible optimization of additional dimensions of treatment planning including using a different number of needles and using mixed seed types. | 10-02-2008 |
| 20080262286 | SPECIFIC INHIBITION OF CPLA2 ENHANCES THE EFFICACY OF RADIOTHERAPY - A method for increasing the radiosensitivity of a target tissue in a subject is disclosed. In some embodiments, the methods includes administering a cytosolic phospholipase A2 (cPLA | 10-23-2008 |
| 20090030257 | Anti-microbial photodynamic therapy - Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is a special spacer connecting at least one photosensitizer to a microorganism receptor (vector) which in turn binds selectively to the surface of a microorganism bringing about photo-destruction upon irradiation. Spacers having hydrophilic structure such as ethylene glycol units and amino carboxyl end capped ethylene glycol units must be used for linking the vector to the photosensitizer. In a preferred embodiment a spacer would have at least 3 ethylene glycol units and be end capped with a carboxyl group on one end and a amino group at the other end. The present invention effectively works to combat bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or at least nearby of selected length and structure, in preferred embodiments, are used for linking the vector to the photosensitizer. These conjugate are found to be very effective in combating bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or a least nearby. A method of use is also provided. | 01-29-2009 |
| 20090069623 | METHODS AND COMPOSITIONS FOR TREATMENT OR PREVENTION OF RADIATION-INDUCED FIBROSIS - The present invention comprises methods and compositions for the treatment or prevention of radiation-induced fibrosis. Methods and compositions for the inhibition of CTGF are disclosed herein. Methods and compositions for treatment of neoplastic disease are disclosed herein. Inhibition of CTGF in humans or animals that have been exposed to ionizing radiation results in treatment or prevention of radiation-induced fibrosis. | 03-12-2009 |
| 20090082608 | Calculation of probable accumulated dosages based on patient movement - A stochastic patient movement model and a dosage delivery plan are used to determine probabilities of dosages received by a target volume during a radiation treatment. The stochastic patient movement model is created by identifying possible sequences of patient positions during the treatment with probabilities specified for each. The dosage delivery plan specifies dosage levels and radiation locations over time. Accumulated dosages are calculated for each sequence of patient positions and the dosage delivery plan. The specified probability for each sequence is then correlated to the accumulated dosage for that sequence. | 03-26-2009 |
| 20090203952 | Eyelid plaque - An eyelid plaque and a method of using the plaque to treat eye cancers. The eyelid plaque is placed on the eyelid such that it defines an enclosure within which the radiation source resides. The enclosure defines a radiation shield that reduces radiation entering other organs and structures proximate the cancer being treated. | 08-13-2009 |
| 20090292156 | ALGORITHM AND PROGRAM FOR THE HANDLING AND ADMINISTRATION OF RADIOACTIVE PHARMACEUTICALS - An algorithm and associated program for performing method steps in the maintaining of records and generating of reports used in the processing of radioactive pharmaceuticals. The algorithm is used as the basis of a program which can accomplish this method automatically. The method involves the determination of dose, the acquisition of the materials, scheduling for the issuance of doses and for future doses, the actual monitoring and control of material and equipment disposal. The algorithm and method are also adapted for the generation of reports on a periodic basis. In short, the method performed by the algorithm allows for an automation through a computer system and this, in turn, allows for the automatic processing of the steps performed and the controls involved in the dispensing of radioactive pharmaceuticals and automatically allows for the generation of governmental and other reports therefor. | 11-26-2009 |
| 20100016649 | External Beam Radiotherapy And Imaging With Radioactive Isotope - A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source. | 01-21-2010 |
| 20100081857 | SYSTEM, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR PLANNING COMBINED THERAPY - A system and method for planning a necrosis-inducing therapy and subsequent administration of a necrosis-targeting agent are described. The system takes into account the effect of necrosis-induction therapy as a basis for the biodistribution estimate of the necrosis-targeting agent. This interaction between the different calculation steps is essential for an accurate planning result. A computer-readable medium and use are also provided. | 04-01-2010 |
| 20100113860 | TEMPORARY TATTOO COVER AND RELATED METHOD - A cover for protecting a temporary mark on a person's skin includes a transparent layer and an associated opaque layer, wherein the opaque layer features an opening through which the temporary mark may be located as the cover is applied. An adhesive is superimposed upon the transparent layer in order to releasably affix the cover to the temporary mark, and also to permit maintaining the cover on a backing material during transportation or storage. During use, the mark is sighted through the transparent layer and the opening in the opaque layer, and applied to the patient's skin. The opaque layer is then removed from the transparent layer, which remains in place over the temporary mark, permitting the person to bathe or otherwise participate unhindered in his or her life's routines without smudging, wearing or removing the mark. | 05-06-2010 |
| 20100268012 | Radioprotective materials, methods of transport and utilization thereof, nanoscale-microscale supramagnetic and supraconducting particles, spherical flow dynamics and sonoluminesence - A spherical sonoluminesence chamber is treated with a positively charged transducer at one end and a negatively charged transducer at the other end, and a charge is applied to a medium of helium or other gas or liquid, with the anions, cat ions, or oxides of our selected particles dispersed therein. With the application of sufficient energy, a supraconducting entity is thus achieved via cooper-pair bonding, with techniques for enhancing the entity's paraconducting and supraconducting properties. Applications for using these novel entities in a variety of arenas are disclosed. | 10-21-2010 |
| 20110065974 | METHOD FOR DETERMINING AN IRRADIATION PLAN - A method for determining an irradiation plan includes specifying a target volume to be irradiated and a condition to be fulfilled, and implementing a first optimization. Implementing the first optimization includes providing a first data record, in which the target volume is mapped, and determining a first parameter set for the irradiation planning by implementing a first optimization algorithm. The first parameter set is optimized with respect to the condition to be fulfilled by using the first data record. The method also includes implementing a second optimization that includes providing a second data record that has a higher resolution than the first data record, determining a second parameter set by implementing a second optimization algorithm. The second parameter set is optimized with respect to the condition to be fulfilled by using the second data record and using the first parameter set. The method also includes generating an irradiation planning data record from the second parameter set. | 03-17-2011 |
| 20110087061 | RADIOTHERAPY APPARATUS CONTROL APPARATUS AND SPECIFIC SITE POSITION MEASURING METHOD - A specific site location measuring method according to the present invention, includes: calculating matching degrees based on a plurality of transmission images imaged by use of radiation transmitting through a specimen and a template set; selecting a template transmission image from the plurality of transmission images based on the matching degrees; adding a new template generated based on the template transmission image, to the template set; imaging a location measurement transmission image by use of radiation transmitting through the specimen; selecting an optimal template that is the most similar to a portion of the location measurement transmission image, from the template set by performing pattern matching of each of templates of the template set with the location measurement transmission image; and calculating a specific site location based on the location measurement transmission image and the optimal template. At this time, the transmission image of the specimen has a high probability that it is similar to any template of the thus-generated templates. Therefore, in the specific site location measuring method, the specific site can be measured with higher precision. | 04-14-2011 |
| 20110092759 | MOBILE SYSTEM FOR ELECTRON BEAM INTRAOPERATIVE RADIATION THERAPY - A mobile system for electron beam intraoperative radiation therapy uses a race-track microtron placed in a housing playing the role of the vacuum chamber, which is supported by a positioner providing its motion with six degrees of freedom with respect to a patient. The positioner is a part of a mobile mechanical structure which houses an ion pump, a microwave source, waveguide elements, a modulator with a pulse transformer and a cooler. The intraoperative radiation therapy system has a tube-like unit which couples the vacuum chamber with the mobile supporting mechanical structure and provides three functions, namely pumping out of the air from the vacuum chamber, feeding of the race-track microtron accelerating structure with radiofrequency power and rotation of the vacuum chamber with respect to the horizontal axis of the unit. | 04-21-2011 |
| 20110092760 | Device For Selecting A Beam Triggering Apparatus - The present invention is related to device for selecting one of several triggering apparatuses, which are simultaneously connectable to said device. The triggering apparatuses are arranged for producing each a triggering signal to enable/disable one or more components of a radiation treatment apparatus. The triggering signals depend on detected parameters. The device includes means for receiving triggering signals from the several triggering apparatuses, when all of the apparatuses are connected to the device, input means for selecting one of the triggering apparatuses, means for generating a universal triggering signal for the one or more components on the basis of said received triggering signal from the selected triggering apparatus, and means for sending the universal triggering signal to the one or more components. | 04-21-2011 |
| 20110098522 | Particle Beam Treatment System - A particle beam treatment system comprising a beam generating unit for generating and adjusting the kinetic energy of a beam of charged particles, comprising at least two beam guide units for feeding the beam of charged particles to a treatment location associated with the respective beam guide unit, wherein each beam guide unit comprises at least one beam deflection unit and/or at least one beam forming unit. The at least two beam guide units are designed for different areas of the kinetic energy of the charged particles such that the at least one beam deflection unit and/or the at least one beam forming unit of each beam guide unit are tailored to the energy of the particles and/or to beam characteristics of the particle beam. The invention further relates to a particle beam treatment method and use of the particle beam treatment system. | 04-28-2011 |
| 20110105821 | Quick Regulation of the Range of High-Energy ION Beams for Precision Irradiation of Moving Target Volumes - The invention concerns a device and a process for adjusting the range of an ion beam, in particular for irradiation in tumor therapy. For this purpose, first the reference position of a target volume to be irradiated is determined. Subsequently, the range of an ion beam is configured such that said beam is adjusted to the reference position of the target volume, in such a manner that the Bragg peak, i.e. the maximal energy loss and thereby the maximal damage occurs in the region of the target volume which is to be destroyed. In the case that it has been determined that the reference position has been altered by a movement of the target volume, the ion beam is then deflected from the beam axis such that the ion beam is directed to various regions of a range modulator, in order that the ion beam experience a correspondingly adjusted energy loss in passing through the range modulator. This energy loss is adjusted to correspond to the change in position of the target volume in such a manner that the change in position is compensated for by the adjustment of the range of the ion beam, and the Bragg peak is returned to the region within the target volume. | 05-05-2011 |
| 20110105822 | BALLOON CATHETER AND X-RAY APPLICATOR COMPRISING A BALLOON CATHETER - The invention relates to a balloon catheter for an X-ray applicator and an X-ray applicator—for use with the corresponding balloon catheter. Said balloon catheter can be filled with a medium and comprises a balloon—that expands with respect to the volume and a catheter shaft for inserting the X-ray applicator. Said balloon or the catheter shaft comprises a rigid inner end piece in the extension of the catheter shaft. | 05-05-2011 |
| 20110112351 | METHOD AND SYSTEM FOR EVALUATING QUALITY ASSURANCE CRITERIA IN DELIVERY OF A TREATMENT PLAN - System and method of determining whether a component of a radiation therapy system is operating within a dosimetric tolerance. The method can include the acts of generating a treatment plan for a patient, the treatment plan specifying a radiation amount to be delivered to the patient, delivering radiation to the patient according to the treatment plan, obtaining feedback during the delivery of radiation, the feedback related to one of a position, a velocity, and an acceleration for one of a multi-leaf collimator, a gantry, a couch, and a jaws, generating a mathematical model based on the feedback for one of the multi-leaf collimator, the gantry, the couch, and the jaws, calculating a delivered dose amount based on the mathematical model and treatment plan information, calculating a deviation in dose between the radiation amount specified in the treatment plan and the delivered dose amount, and determining whether the deviation in dose is within a dosimetric tolerance for the one of the multi-leaf collimator, the gantry, the couch, and the jaws. | 05-12-2011 |
| 20110118527 | METHOD TO DERIVE ANATOMICAL AND/OR PATHOLOGICAL STRUCTURES FROM DATA OF IMAGING TECHNOLOGIES - A method to derive anatomical and/or pathological structures from non-invasive imaging technologies is provided. Non-invasive imaging technologies are computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), surface scans and others. Imaging data obtained by non-invasive technology is used to create a surface contour. The imaging data is transmitted to rapid prototyping apparatus readable data. At hand of this readable data the rapid prototyping apparatus establishes a positive or negative surface model, such as a fixation device, a mask or a prosthesis or other instruments for medical purposes. | 05-19-2011 |
| 20110118528 | Methods and Nutritional Formulations to Increase the Efficacy and Reduce the Side Effects of Cancer Treatment - The present invention relates to methods of protecting patients and sensitizing cancer cells in combination with chemotherapy and/or radiation therapy. More specifically, the invention provides nutritional methods and formulations that are capable of reducing cancer growth without causing chronic weight loss in patients, protecting normal cells, tissues and organs from chemotherapy and/radiation therapy, and sensitizing cancer cells against low, normal and high-dose chemotherapy. Some of the methods also impede cancer growth even without chemotherapy. | 05-19-2011 |
| 20110118529 | MULTI-AXIS / MULTI-FIELD CHARGED PARTICLE CANCER THERAPY METHOD AND APPARATUS - The invention relates to a method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field raster beam charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, beam movement velocity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue. | 05-19-2011 |
| 20110118530 | CHARGED PARTICLE BEAM INJECTION METHOD AND APPARATUS USED IN CONJUNCTION WITH A CHARGED PARTICLE CANCER THERAPY SYSTEM - The invention comprises a charged particle beam injection method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam source includes a negative ion beam source, vacuum system, an ion beam focusing lens, and/or a tandem accelerator. The negative ion beam source uses electric field lines for focusing a negative ion beam. The negative ion source plasma chamber includes a magnetic material, which provides a magnetic field barrier between a high temperature plasma chamber and a low temperature plasma region. The injection system vacuum system and a synchrotron vacuum system are separated by a conversion foil, where negative ions are converted to positive ions. The foil is sealed to the edges of the vacuum tube providing for a higher partial pressure in the injection system vacuum chamber and a lower pressure in the synchrotron vacuum system. | 05-19-2011 |
| 20110118531 | MULTI-AXIS CHARGED PARTICLE CANCER THERAPY METHOD AND APPARATUS - The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor. | 05-19-2011 |
| 20110124946 | FLUID TRANSFER FOR RADIATION TREATMENT APPARATUS - Techniques and systems for supplying fluid to a rotating gantry portion of a radiation treatment apparatus are disclosed where a first batch fluid is supplied to the rotating gantry when the rotating gantry is stationary a first time, discontinuing the supply when the rotating gantry is rotating, and supplying a second batch of fluid when the rotating gantry is stationary a second time. A storage component on the rotating gantry allows supplied fluid to be stored in the rotating gantry and used to shape a radiation beam and/or cool an ionizing radiation source, for example, while the rotating gantry is rotating. The techniques and systems may also be utilized to discharge a first fluid from the rotating gantry and supply a second fluid to replace the first fluid. | 05-26-2011 |
| 20110130613 | MECHANOLUMINESCENT X-RAY GENERATOR - A device for generating x-rays has an enclosing vessel having a structure suitable to provide an enclosed space at a predetermined fluid pressure, wherein the enclosing vessel has a window portion and a shielding portion in which the shielding portion is more optically dense to x-rays than the window portion; a mechanoluminescent component disposed at least partially within the enclosing vessel; and a mechanical assembly connected to the mechanoluminescent component. The mechanical assembly provides mechanical energy to the mechanoluminescent component while in operation, and at least some of the mechanical energy when provided to the mechanoluminescent component by the mechanical assembly is converted to x-rays. | 06-02-2011 |
| 20110130614 | PROSPECTIVE ADAPTIVE RADIATION THERAPY PLANNING - A therapy planner ( | 06-02-2011 |
| 20110137102 | STEREOTACTIC INTRACRANIAL TARGET LOCALIZATION GUIDANCE SYSTEMS AND METHODS - Systems and methods of intracranial target localization using non-radiological direct surface imaging of one or more of the upper teeth. | 06-09-2011 |
| 20110160513 | SYSTEM AND METHODS FOR USING A DYNAMIC GAMMA KNIFE FOR RADIOSURGERY - The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system. | 06-30-2011 |
| 20110166407 | Heart Treatment Kit, System, and Method For Radiosurgically Alleviating Arrhythmia - Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy. | 07-07-2011 |
| 20110166408 | HEART TISSUE SURFACE CONTOUR-BASED RADIOSURGICAL TREATMENT PLANNING - A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan. | 07-07-2011 |
| 20110166409 | EGFR AND PTEN GENE ALTERATIONS PREDICTS SURVIVAL IN PATIENTS WITH BRAIN TUMORS - The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients. | 07-07-2011 |
| 20110184220 | METHODS FOR THE TREATMENT OF RADIATION OR CHEMOTHERAPY-INDUCED TISSUE DAMAGE - The present invention relates to methods for preventing or treating toxicities associated with exposure to ionizing radiation or to chemotherapy. Particularly, the present invention relates to methods for preventing or treating toxicities associated with radiation or chemotherapy comprising administering to a subject in need of such treatment polypeptide complexes comprising an IL-6 linked to a soluble IL-6 receptor, the polypeptide complexes capable of preventing or treating toxicities, particularly xerostomia. | 07-28-2011 |
| 20110184221 | ELONGATED LIFETIME X-RAY METHOD AND APPARATUS USED IN CONJUNCTION WITH A CHARGED PARTICLE CANCER THERAPY SYSTEM - The system uses an X-ray imaging system having an elongated lifetime. Further, the system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source located proximate to the charged particle beam path. By generating the X-rays near the charged particle beam path, an X-ray path running collinear, in parallel with, and/or substantially in contact with the charged particle beam path is created. The system then collects X-ray images of localized body tissue region about a cancerous tumor. Since, the X-ray path is essentially the charged particle beam path, the generated image is usable for precisely target the tumor with a charged particle beam. | 07-28-2011 |
| 20110201866 | BRACHYTHERAPY METHOD OF TREATING SKIN TUMORS USING A TAILOR-MADE RADIOACTIVE SOURCE - The present invention refers to a method of treating a cancerous or non-cancerous skin lesion of a subject, e.g. a human patient, by epidermal radioisotope therapy, a specialized type of brachytherapy, comprising the steps of (a) defining and marking an area of skin to be treated; (b) covering said area with a protective layer, e.g. a protective film or foil; (c) applying a tailor-made radioactive source by applying a layer of a radioactive source material on said protective layer, such that said area is covered by said material while any area not to be treated is spared; and (d) removing the radioactive source after a predetermined time period of irradiation. | 08-18-2011 |
| 20110207985 | PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS - Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed. | 08-25-2011 |
| 20110207986 | SYSTEM AND METHOD FOR RADIATION DOSE REDUCTION IN MOLECULAR BREAST IMAGING - A system and method is provided for analyzing detector data acquired during molecular breast imaging (MBI) that reduces a patient's radiation does without a reduction in image quality. The method processes and combines initial images acquired by the two gamma-camera detectors of the MBI system to produce a hybrid or composite image set having reduced noise and improved contrast. The composite image provides image quality comparable to that of traditional MBI methods, but at a lower patient radiation dose. | 08-25-2011 |
| 20110213192 | Inorganic Nanoparticles of High Density to Destroy Cells In-Vivo - The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X- Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same. | 09-01-2011 |
| 20110218379 | EPITOPES DERIVED FROM SATB2 AND USES THEREOF - The present invention relates to an affinity ligand capable of selective interaction with an epitope sequence consisting of 47 amino acids or less and comprising the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2. Further, it relates to a polypeptide consisting of the epitope sequence and to uses of the affinity ligand and the polypeptide. | 09-08-2011 |
| 20110224475 | ROBOTIC MOBILE ANESTHESIA SYSTEM - A mobile anesthesia system has a patient support configured for use with a robotic patient positioning system. There is a sliding rail system disposed on the patient support and an anesthesia machine coupled to the slide rail system. Through use of the rail system(s) on the patient support a anesthesia machine may move relative to a patient support from a stored configuration clear of the patient to a treatment configuration above the patient. A method of providing anesthesia to a patient positioned to receive a robotic assisted radiation therapy is also described. The method proceeds by positioning a patient on a robotic couch in a location remote to a radiation therapy treatment room used to perform the robotic assisted radiation therapy. Next, anesthesia is administered to the patient from an anesthesia machine attached to the robotic couch while both the patient and the robotic couch are in the location remote to the radiation therapy treatment room. Thereafter, the robotic couch is placed under the control of a patient positioning system in the radiation therapy treatment room. The patient and the robotic couch are then maneuvered into a treatment position while administering anesthesia to the patient from the anesthesia machine. | 09-15-2011 |
| 20110224476 | Method and Apparatus for Treatment of Discogenic Pain - A back pain treatment system includes a patient support, a radiation source, a radiation delivery mechanism, and a treatment planning computer adapted to control the radiation delivery mechanism. The treatment planning computer is programmed to deliver radiation from the radiation source to a treatment volume including a blood vessel. | 09-15-2011 |
| 20110237858 | Device and Methods for Sequential, Regional Delivery of Multiple Cytotoxic Agents and Directed Assembly of Wound Repair Tissues - An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of intercommunicating void spaces. A first cytotoxic agent in the preferred form of cisplatin is joined to the macrostructure during formation. A microstructure in the preferred form of a blend of high molecular weight hyaluronic acid conjugated with a second cytotoxic agent in the preferred form of paclitaxel and of pure high molecular weight hyaluronic acid is invested in the void spaces. Thus, when implanted, the paclitaxel and cisplatin are released sequentially, each initially at high level concentrations followed by lower release. Radiotherapy can be begun after the release of the paclitaxel has been completed but while the cisplatin is being released. | 09-29-2011 |
| 20110237859 | THERAPEUTIC APPARATUS - A therapeutic apparatus comprising: a magnetic resonance imaging system adapted for acquiring a set of magnetic resonance imaging data in an imaging zone, the magnetic resonance imaging system comprising a means for generating a magnetic field, a guiding means adapted for guiding a beam of charged particles to a target zone within a subject, wherein the imaging zone comprises the target zone, a zone determination means adapted for determining the location of the target zone within the subject using the set of magnetic resonance imaging data, a trajectory calculation means adapted for calculating a trajectory of the beam using magnetic field data being descriptive of the magnetic field such that the calculated trajectory reaches the target zone, a control means adapted for controlling the guiding means using the calculated trajectory such that the beam follows the calculated trajectory. | 09-29-2011 |
| 20110245577 | COMBINATION WITH BIS (THIOHYDRAZIDE AMIDES) FOR TREATING CANCER - Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy. | 10-06-2011 |
| 20110257457 | RADIATION TREATMENT SYSTEMS - Disclosed are radiation treatment systems with enhanced control architectures that enable more complex treatment plans to be implemented, and radiation treatment systems with enhanced resistance to the effect of neutrons. An exemplary control architectures comprises: a digital packet network; a supervisor electrically coupled to the digital packet network and having a treatment plan; and a plurality of nodes, each node coupled to digital packet network and controlling one or more treatment-related components of the radiation treatment system; and wherein the supervisor periodically communicates control orders to the nodes over the digital packet network. | 10-20-2011 |
| 20110257458 | METHOD OF USING TUMOR CELL DEBRIS TO REDUCE BRAIN TUMOR RECURRENCE OR GROWTH - The present invention describes compositions comprising tumor cell debris, tumor lysate or tumor antigens and methods of using tumor cell debris, tumor lysate or tumor antigens for stimulating a specific immune response. The compositions may further comprise at least one TLR ligand. The stimulation of the specific immune response may be used to treat tumors, particularly, brain tumors. The treatment method may also reduce the recurrence of a tumor and/or inhibit or slow down the growth of a tumor. | 10-20-2011 |
| 20110263920 | ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS - The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes | 10-27-2011 |
| 20110306818 | Irradiation of a Target Volume, Taking into Account a Volume to be Protected - The idea concerns irradiation of a target volume ( | 12-15-2011 |
| 20110313228 | RADIOTHERAPY APPARATUS CONTROL METHOD AND RADIOTHERAPY APPARATUS CONTROL APPARATUS - A radiotherapy apparatus control method according to the present invention includes: a step S | 12-22-2011 |
| 20110313229 | Therapy Targeting Cancer Stem Cells - Disclosed herein are new immunotherapy methods that involve the isolation of cancer stem cells from tumor tissue and use of the cells either directly or indirectly through proteins or other factors associated with the cells to activate antigen presenting cells. The activated antigen presenting cells are useful as a therapy against the tumor. Also disclosed herein are novel methods of isolating and characterizing cancer stem cells and producing individual cancer stem cell lines. Dendritic cell lines are also disclosed herein. | 12-22-2011 |
| 20110313230 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 12-22-2011 |
| 20110313231 | RADIATION SYSTEMS - A radiation system includes a first ring, a radiation source capable of providing radiation suitable for treating a patient, the radiation source secured to the first ring, a second ring located behind the first ring, and an imager secured to the second ring. A radiation system includes a first device having a radiation source capable of generating a radiation beam suitable for treating a patient, and a second device having imaging capability, wherein the first device is oriented at an angle that is less than 180° relative to the second device. A radiation system includes a structure having a first opening, a radiation source rotatably coupled to the structure, an imaging device rotatable relative to the structure, and a processor for controlling a rotation of the radiation source and a rotation of the imaging device, wherein the radiation source is rotatable relative to the imaging device. | 12-22-2011 |
| 20110313232 | Multi-Field Charged Particle Cancer Therapy Method and Apparatus - The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field charged particle cancer therapy method and apparatus coordinated with negative ion beam creation, ion beam focusing, charged particle acceleration, patient rotation, and/or patient respiration. Preferably, the charged particle therapy is performed on a patient in a partially immobilized and repositionable position. Proton delivery is preferably timed to patient respiration via control of charged particle beam injection, acceleration, and/or targeting methods and apparatus. | 12-22-2011 |
| 20120004492 | MARKER ADAPTED NORMAL TISSUE COMPLICATION PROBABILITY - A therapy system includes a diagnostic image scanner ( | 01-05-2012 |
| 20120029260 | Screening and Treatment Method - The invention provides a method to analyze an effect of a biological insult such as exposure to ionizing radiation comprising (a) exposing one or more groups of subjects to a biological insult of at least about an LD | 02-02-2012 |
| 20120029261 | SYSTEMS AND METHODS FOR DELIVERY OF A THERAPEUTIC AGENT - Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems. | 02-02-2012 |
| 20120035407 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 02-09-2012 |
| 20120035408 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 02-09-2012 |
| 20120035409 | BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF - This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders. | 02-09-2012 |
| 20120041250 | TARGET TRACKING DEVICE AND RADIATION THERAPY APPARATUS - An X-ray fluoroscopic unit simultaneously acquires a plurality of X-ray fluoroscopic images with different sensitivities in one direction. An image processing unit detects a target on the basis of the plurality of X-ray fluoroscopic images acquired in each direction. | 02-16-2012 |
| 20120041251 | CHARGED PARTICLE CANCER THERAPY X-RAY METHOD AND APPARATUS - The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation. | 02-16-2012 |
| 20120071704 | MITOCHONDRIAL LOCALIZATION OF MUC1 - The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either or both of HSP70 and HSP90. Also embraced by the invention are in vivo and in vitro methods of inhibiting such an interaction. | 03-22-2012 |
| 20120078028 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS - Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer. | 03-29-2012 |
| 20120083645 | ECG-CORRELATED RADIOTHERAPY - A method of delivering radiation includes obtaining a first signal that represents a cardiac state of the subject, and generating a control signal using a processor to operate a component of a treatment radiation machine based at least in part on the first signal. A method of delivering radiation includes determining a cardiac state of the subject, and generating a control signal using a processor to operate a component of a treatment radiation machine based at least in part on the determined cardiac state. | 04-05-2012 |
| 20120095277 | Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers - Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, antibodies specific for hyaluronan receptors, hyaluronan mimetics, inhibitors of hyaluronan synthesis, and stimulators of hyaluronan degradation. | 04-19-2012 |
| 20120108880 | CHROMOSOME 3p21.3 GENES ARE TUMOR SUPPRESSORS - Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3. | 05-03-2012 |
| 20120123182 | DEVICES FOR THERMALLY INDUCED TRANSFORMATIONS CONTROLLED BY IRRADIATION OF FUNCTIONALIZED FULLERENES - An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation. | 05-17-2012 |
| 20120123183 | TELETHERAPY LOCATION AND DOSE DISTRIBUTION CONTROL SYSTEM AND METHOD - A method of adjusting an irradiation treatment plan, the plan constituted of: obtaining a plurality of reference scans of a target tissue over a breathing cycle; obtaining a pre-treatment scan of the target tissue; identifying the reference scan whose phase is consonant with the obtained pre-treatment scan; computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan; applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to obtain at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the at least one synthetic scan. | 05-17-2012 |
| 20120123184 | SYSTEMS AND METHODS FOR OPTIMIZATION OF ON-LINE ADAPTIVE RADIATION THERAPY - Radiation treatment methods comprise: obtaining initial image data of a region of interest; initially optimizing one or more radiation delivery variables of a radiation treatment plan based on the initial image data; and dividing the plan into one or more fractional treatments. Each fractional treatment comprises: delivering an initial portion of a fraction based on the one or more initially optimized radiation delivery variables; obtaining fractional image data pertaining to the region of interest; fractionally optimizing the one or more radiation delivery variables based at least in part on the fractional image data; and delivering a subsequent portion of the fraction based on the one or more fractionally optimized radiation delivery variables. At least part of delivering the initial portion of the fraction overlaps temporally with at least one of: obtaining the fractional image data and fractionally optimizing the one or more radiation delivery variables. | 05-17-2012 |
| 20120123185 | RECTAL BALLOON APPARATUS WITH PRESSURE RELIEVING LUMEN AND SENSORS - A rectal balloon apparatus comprises a shaft having a fluid passageway extending therethrough. A rectal gas relieving lumen may be positioned with the shaft for removal of rectal gas. A motion detecting sensor and a radiation detecting sensor may be positioned with the balloon, the shaft, and/or the rectal gas release lumen. | 05-17-2012 |
| 20120123186 | THERAPEUTIC REGIMEN FOR TREATING CANCER - The invention provides a method for treating locally advanced resectable esophageal cancer in a human comprising (a) administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding a human TNF-α and operably linked to a promoter, wherein the dose comprises about 4×10 | 05-17-2012 |
| 20120130144 | TREATMENT OF LUNG CANCER WITH A NITROBENZAMIDE COMPOUND IN COMBINATION WITH A GROWTH FACTOR INHIBITOR - In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. | 05-24-2012 |
| 20120130145 | SYSTEM AND METHOD FOR PERFORMING A COMPREHENSIVE HEALTH ASSESSMENT - A system and method for providing a comprehensive overall health assessment is disclosed. A health assessment system includes first and second support structures oriented in a vertical fashion and spaced apart from one another to define a scanning area configured to receive a subject to be scanned, an x-ray imaging system incorporated into the first and second support structures and configured to acquire x-ray image data from the subject in a standing position, and at least one additional data acquisition device configured to acquire health related data from the subject. The health assessment system also includes a computer programmed to receive the x-ray image data and the health related data and generate a diagnostic output based on the x-ray image data and the health related data, the diagnostic output comprising at least one of a health related diagnosis and a recommendation for future action. | 05-24-2012 |
| 20120130146 | CONTINUOUS ADMINISTRATION OF CILENGITIDE IN CANCER TREATMENTS - The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising the continuous administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agent or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. | 05-24-2012 |
| 20120130147 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS - Compounds of the formula (I), in which R | 05-24-2012 |
| 20120130148 | PHARMACEUTICAL COMPOSITION - To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. | 05-24-2012 |
| 20120136194 | AUTOMATED TREATMENT PLANNING FOR RADIATION THERAPY - This patent generally relates to developing treatment plans for use in external beam radiation therapy, and more particularly to a method, a system and a computer readable media that contains programming for the development of external beam radiation therapy treatment plans. Embodiments of the invention include (1) automatically setting beam angles based on a beam angle automation algorithm, (2) judiciously designing planning structures and (3) automatically adjusting the objectives of the objective function based on a parameter automation algorithm. | 05-31-2012 |
| 20120157746 | INTERACTIVE COMPUTER-AIDED EDITOR FOR COMPENSATORS USED IN RADIOTHERAPY TREATMENT PLANNING - When constructing compensators for radiation therapy using ion or proton radiation beams, a computer-aided compensator editing method includes overlaying an initial 3D compensator model on an anatomical image of a target mass (e.g., a tumor) in a patient, along with radiation dose distribution information. A user manipulates pixels or voxels in the compensator model on a display, and a processor automatically adjusts the dose distribution according to the user edits. The user iteratively adjusts the compensator model until the dose distribution is optimized, at which time the optimized compensator model is stored to memory and/or output to a machining device that constructs a compensator from | 06-21-2012 |
| 20120157747 | PULSED ELECTROMAGNETIC FIELD AND NEGATIVE PRESSURE THERAPY WOUND TREATMENT METHOD AND SYSTEM - A method for treating a wound of an individual and for enhancing a rate of wound healing by applying, for a first period of time, a negative pressure treatment to the wound without applying a pulsed radio frequency treatment; and applying, for a second period of time subsequent to the first period time, a pulsed radio frequency energy treatment to the wound while maintaining the negative pressure treatment to enhance the rate of wound healing. The negative pressure treatment and the pulsed radio frequency energy treatment are applied concurrently for the duration of the second period of time. | 06-21-2012 |
| 20120172650 | USE OF SOMATOSTATIN OR AN ANALOGUE THEREOF IN COMBINATION WITH EXTERNAL RADIATION THERAPY - Use of somatostatin or analogues thereof to enhance the effects of radiation on cellular proliferation and apoptosis, particularly use of somatostatin combined with externally applied radiation to treat neuroendocrine tumors and/or acromegaly. | 07-05-2012 |
| 20120190909 | USES OF IL-12 IN HEMATOPOIESIS - Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of Il-12 for bone marrow preservation or recovery. | 07-26-2012 |
| 20120197058 | Grid Radiotherapy for Static and Dynamic Treatment Delivery - Some aspects include a system, method, and computer-readeable medium to divide a representation of a target volume into an array of sub-volumes; define a high dose volume to which a high dose of radiation is to be delivered; define a plurality of sampling volumes; direct an estimated dose of radiation to each sub-volume; determine whether the dose of radiation delivered to each high dose volume is at least a minimum threshold dose, and that the radiation delivered to the plurality of sampling volumes for each of the sub-volumes is at least a minimum difference less than the radiation delivered to the high dose volume; adjust the estimated dose of radiation directed to each sub-volume; and develop a radiation treatment plan, including the adjusted dose, to invoke a biological effect of spatially separated radiation. | 08-02-2012 |
| 20120197059 | UBIQUITIN INTERACTING MOTIF PEPTIDES AS CANCER THERAPEUTICS - The present invention involves the use peptides comprising ubiquitin interacting motifs (UIMs) alone or in combination with other agents to treat diseases involving neovascularization, such as cancer. | 08-02-2012 |
| 20120197060 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY - Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti | 08-02-2012 |
| 20120203050 | METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF - The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses. | 08-09-2012 |
| 20120203051 | TREATMENT OF CANCER USING THE SODIUM SALT OF A BENZOIC ACID DERIVATIVE - The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy. | 08-09-2012 |
| 20120203052 | THERAPEUTIC REGIMEN FOR TREATING CANCER - The invention provides a method for treating cancer in a human comprising administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding TNF-α operably linked to a promoter, wherein the dose comprises about 1×10 | 08-09-2012 |
| 20120203053 | SEQUENTIAL OPTIMIZATIONS FOR TREATMENT PLANNING - A method and apparatus for radiation treatment planning are described. The method includes receiving a plurality of radiation treatment-planning parameters, and sequentially optimizing the plurality of radiation treatment-planning parameters. | 08-09-2012 |
| 20120209050 | NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF - The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations. | 08-16-2012 |
| 20120215049 | PARTICLE BEAM THERAPY SYSTEM - The objective is to obtain a particle beam therapy system that prevents dispersion of a charged particle beam, reduction of the energy thereof, and upsizing of the system and that can accurately monitor the opening shape of a multileaf collimator so as to perform high-accuracy particle beam therapy. An image-capturing unit that takes an image of an outer end of a respective downstream side face of a leaf plate is provided for each row of leaves in such a way as to be situated at a position that is at an outer side of an irradiation field; and adjusted in such a way that the base of a perpendicular from a viewpoint to the downstream side face, is situated at a position that is at an inner side of the position of the outer end when the leaf plate is maximally driven in the departing direction. | 08-23-2012 |
| 20120215050 | Method and apparatus for producing quantum entanglement and non-local effects of substances - A method and apparatus are disclosed which produce quantum entanglement and non-local effects of various substances on responsive targets such as biological and/or chemical systems through quantum entanglement. In one broad embodiment, the apparatus includes a quantum entanglement generating source, said source emitting a plurality of quantum-entangling members such as photons when said source operates; and a substance disposed adjacent to said source, said substance being responsive to said members; such that when said source emits said members which pass through said substance and a biological system, said members first quantum-entangle with quantum entities in said substance, then travel to said biological system such as a human body and subsequently entangle with quantum entities inside the biological system producing non-local effect of the substance on said biological system through quantum entanglement. | 08-23-2012 |
| 20120215051 | Radiotherapeutic Apparatus - The ability to provide a fine resolution variation in the dose rate of radiotherapeutic apparatus would allow delivery times of VMAT and related techniques to be reduced significantly. A radiotherapeutic apparatus is described, comprising a source of radiation able to issue pulses of radiation at a base frequency, and a control apparatus arranged to permit pulses provided these match a pulse pattern chosen to achieve a selected time-averaged power level, the chosen pulse pattern being one selected from a plurality of pulse patterns that include patterns consisting of trains of pulses that include, relative to the base frequency, at least every n | 08-23-2012 |
| 20120220811 | Radiation Treatment Method For Use With A Radiation Treatment Bra - A method for radiation treatment includes adjusting a plurality of adjustable elements on a radiation treatment bra to establish a reference breast geometry and aligning the patient to a radiation treatment machine by projecting a light field through windows provided in the radiation treatment bra during a radiation treatment planning session. To begin actual radiation treatment, the reference breast geometry is reestablished by repeating the original adjustments of the adjustable elements, as necessary. Alignment is re-established by viewing tattoos through the windows in conjunction with the light field. | 08-30-2012 |
| 20120226090 | Protection Against and Treatment of Ionizing Radiation - Methods of preparing a proteoliposorne comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposorne. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds, and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds. In addition, RalBP1 is effective for the protection and treatment of mammals against the effects of ionizing radiation. | 09-06-2012 |
| 20120232324 | Device And Method For 3D Dose Tracking In Radiation Therapy - The present invention relates to a device and method for verification of the quality of a radiation beam in conformal radiation therapy, and in particular for IMRT (Intensity Modulated Radiation Therapy) applications. The actual 3D dose distribution in the patient is tracked during the course of the entire treatment by reconstructing the photon fluences from measured 2D detector responses during irradiation in conjunction with updated patient images. | 09-13-2012 |
| 20120238795 | METHOD AND DEVICE FOR CONTROLLING DOSAGE APPLICATION DURING IRRADIATION - A method for controlling dosage application during irradiation of a moveable target volume in a body with an energy beam by scanning the target volume includes, before irradiating an i-th grid position, determining a dosage during the irradiation process using the movement data, wherein the dosage already contains the i-th grid position during irradiation of the previous grid positions (1<=k| 09-20-2012 | |
| 20120253095 | CREATING A COMPENSATOR FROM SOLID PARTICULATES - A patient-specific compensator is created from solid particulates on-site at a radiation treatment facility and then used there at that facility in conjunction with a radiation therapy machine to deliver radiation therapy to a cancer patient. After use, the compensator can be broken down into loose solid particulates at the facility, and another compensator can be created on-site at the facility from those particulates and used in the radiation treatment of a different cancer patient at the facility. | 10-04-2012 |
| 20120253096 | RADIATION THERAPY APPARATUS AND CONTROL METHOD - According to one embodiment, a radiation therapy apparatus includes a radiation irradiation device, a detector included in a PET scanner, a control unit, and a PET image reconstruction unit. The radiation irradiation device emits a therapeutic radiation. The detector counts light derived from gamma rays, and is provided with a gap portion through which the therapeutic radiation passes on a plane of rotation about the body axis of a subject. The control unit controls the radiation irradiation device and the detector so as to rotate in synchronization with each other in a state capable of emitting the therapeutic radiation to the gap portion. The PET image reconstruction unit reconstructs a PET image based on position information at the time of counting of the detector that nearly coincidentally counts pair annihilation gamma rays in a state where the control unit performs rotation control. | 10-04-2012 |
| 20120253097 | DEVICE SYSTEM AND METHOD FOR TISSUE DISPLACEMENT OR SEPARATION - A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue. | 10-04-2012 |
| 20120259150 | Compositions and Methods of Sphingosine Kinase Inhibitors In Radiation Therapy of Various Cancers - The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and methods of SPK inhibitors, including siRNAs, which specifically block gene expression of SPK and potentiates the effect of radiation in the treatment of various cancers. | 10-11-2012 |
| 20120259151 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE - The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans. | 10-11-2012 |
| 20120259152 | TREATMENT OF HYPOXIC TUMORS WITH LOCALIZED OXYGENATION - Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light. | 10-11-2012 |
| 20120264996 | METHOD AND DEVICE FOR IRRADIATION TREATMENT PLANNING - A method for irradiation treatment planning for a target volume to be irradiated includes specifying a plurality of data sets. The target volume to be irradiated is depicted in each data set of the plurality of data sets. The data sets differ in that the target volume has another position and/or shape. A data set is selected from the plurality of the data sets and other data sets are registered to the selected data set. The method includes forming an amalgamation of the depicted target volumes using the registrations of the other data sets to the selected data set, and determining an area at risk in the selected data set. The method includes modifying the amalgamation of the target volumes such that the area at risk is excluded from the amalgamation of the depicted target volumes. An irradiation treatment plan is calculated using the modified amalgamation of the target volumes. | 10-18-2012 |
| 20120264997 | EXTERNAL IMMOBILIZER - An external immobilizer for cancer treatment has a plurality of inflatable bladders that are independent finable depending on computer instruction based on patient position data provided from integrated or separate position determining means, such as external cameras or sensors, optionally with internal and/or external markers. In preferred embodiments, the immobilizer is fully integrated with an imaging means as well as the external beam radiation source, thus allowing both real time, independent anatomical compensation or correction for patient movement and fine control of beam shape and position to accurately target the tumor, even if the patient moves. | 10-18-2012 |
| 20120264998 | TREATMENT PLANNING APPARATUS AND PARTICLE THERAPY SYSTEM - A charged particle beam reduces treatment time in the uniform scanning or in the conformal layer stacking irradiation. In the uniform scanning, an optimum charged particle beam scan path for uniformly irradiating a collimator aperture area is calculated. In the conformal layer stacking irradiation, an optimum charged particle beam scan path for uniformly irradiating a multi-leaf collimator aperture area of each layer for each of the layers obtained by partitioning the target volume is calculated. Alternatively, a minimum irradiation field size that covers the multi-leaf collimator aperture area of each layer is calculated, and a scan path corresponding to the irradiation field size, prestored in a memory of a particle therapy control apparatus, is selected. The charged particle beam scan path is optimally changed in the lateral directions in conformity with the collimator aperture area in the uniform scanning or in each layer in the conformal layer stacking irradiation. | 10-18-2012 |
| 20120264999 | 4 (PYRROLOPYRIDINYL)PYRIMIDIN-2-YLAMINE DERIVATIVES - Compounds of the formula (I), in which R | 10-18-2012 |
| 20120271093 | Spacer For Ionized Radiation Therapy - Provided is a spacer for ionizing radiation therapy, which can be easily disposed in a living body, does not require abdominal surgery for removing the disposed spacer after radiation therapy, and can effectively separate a tissue to be treated from other tissues. The spacer for ionizing radiation therapy includes a fiber assembly obtained by three-dimensionally entangling a fibrous material formed of a biocompatible synthetic polymeric material. Specifically, the spacer has a thickness of 1 mm to 100 mm. | 10-25-2012 |
| 20120271094 | METHODS FOR PERFORMING RADIOSURGERY USING NON-HOMOGENEOUS STEREOTACTIC TECHNIQUES - The present invention relates to a method for performing non-homogeneous radiosurgery to provide optimal doses to the site of an abnormal lesion and to minimize damages to surrounding healthy tissues. | 10-25-2012 |
| 20120271095 | DEVICE AND METHOD FOR IMMOBILIZING PATIENTS FOR BREAST RADIATION THERAPY - According to the improved systems and methods described herein, a patient may be immobilized so that one or both breasts are returned to a known position. Additionally, the improved systems and methods reduce respiratory movement of the breasts. Thus, the immobilization devices and techniques described herein provide accurate and reproducible breast positioning while simultaneously reducing respiratory motion. | 10-25-2012 |
| 20120289757 | Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject - Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject. | 11-15-2012 |
| 20120289758 | Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject - Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject. | 11-15-2012 |
| 20120289759 | INTERLOCKING VACUUM CUSHION - A method of positioning, holding, and immobilization of a patient on a radiation treatment table or patient support surface. The positioning device is an improved vacuum cushion for the immobilization of a patient's full body on a support surface for some type of therapy to be accurately delivered and repeated. The patient's body is to be positioned in a manner for treatment that can be reproduced during consecutive days of radiotherapy. The upper and lower body cushions both include an outer casing with a valve that is connectable to a vacuum source. The casings contain small spheres. The immobilization device is comprised of upper and lower body cushions, both non-porous, to be evacuated of air. The cushions are adjoined by interlocking frame members fixed at proximal ends of each cushion. The device can be secured on the support surface at predetermined points using commercially available indexing bars during the procedure. | 11-15-2012 |
| 20120289760 | CYTOMEGALOVIRUS-BASED IMMUNOGENIC PREPARATIONS - This disclosure relates to methods of using recombinant replication-deficient cytomegalovirus (CMV) to generate a long-term, repeatedly stimulated T cell-based immune response in a subject, for instance against a heterologous antigen expressed by the cytomegalovirus. It further relates to methods of using a recombinant replication deficient CMV as an anti-cancer immunogenic preparation. | 11-15-2012 |
| 20120296148 | Method and Apparatus Pertaining to Treatment Plans for Dynamic Radiation-Treatment Platforms - A control circuit accesses patient information and treatment-platform information and uses that information to automatically suggest a treatment plan having at least one of a given number of treatment-pathway traversals wherein the given number is permitted to be greater than one and sub-treatment-pathway traversal-based physical alterations to at least one of the dynamic elements of the dynamic radiation-treatment platform. By one approach the aforementioned patient information can refer, at least in part, to the patient's external contour and a treatment target's size and position with respect to the patient. The patient information regarding the treatment target can represent the latter as a simple symmetrical geometric shape (such as a cuboid). The treatment-platform information, in turn, can refer, at least in part, to dynamic elements of the dynamic radiation-treatment platform itself. | 11-22-2012 |
| 20120302815 | MULTI-VALENT POLY-UBL CHAIN INHIBITORS AND METHODS OF USE - A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group. | 11-29-2012 |
| 20120302816 | THERAPEUTIC COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF ACTIVE AGENTS - The present invention pertains to therapeutic compositions that comprise: (1) a nanovector, (2) an active agent; and (3) a targeting agent, wherein the active agent and the targeting agent are non-covalently associated with the nanovector. The present invention also pertains to methods of treating various conditions in a subject by utilizing the above-described therapeutic compositions. Methods of making the therapeutic compositions are also a subject matter the present invention. | 11-29-2012 |
| 20120302817 | METHOD FOR INCREASING MOISTURE CONTENT OF SKIN SURFACE AND IMPROVING MOISTURE-RETAINING FUNCTION OF DERMIS AND BEAUTY APPARATUS THEREFOR - A method for increasing a moisture content of a skin and improving skin elasticity by improving a moisture retaining function of a dermis without generating steam, mist and the like, and a beauty apparatus that supplies moisture to a skin are provided. A user is irradiated with positive and negative ions which are generated by using ion generation means | 11-29-2012 |
| 20120302818 | METHOD OF UTILIZING AN IMPLANT FOR TARGETING EXTERNAL BEAM RADIATION - A method of partial breast radiation therapy includes placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast. | 11-29-2012 |
| 20120310030 | Device And Method For Line Control Of An Energy Beam - The invention relates to the field of line control of a beam, and especially to a device comprising a plurality of ionisation chambers, enabling the measurement of the dose deposited by an ionising beam and the field of said beam. At least one ionisation chamber is formed from support films having a thickness less than or equal to 100 nm. | 12-06-2012 |
| 20120316377 | EFFECTIVE VOLUME FILLING WITH TEMPLATES - A method and a dose planning module for planning a treatment session of a patient by means of a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. The method includes obtaining a target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit, the target volume being modeled as a three-dimensional voxel representation; selecting an isodose level for the planned treatment; determining shots to be delivered during the treatment, each shot being modeled by a spatial dose volume distribution of radiation represented by a three-dimensional voxel representation, the shape of the spatial distribution depending on the specific collimator setting and the selected isodose level; and selecting shots in a decreasing volume order for the dose planning. | 12-13-2012 |
| 20120316378 | BEAM IRRADIATION APPARATUS AND BEAM IRRADIATION CONTROL METHOD - The beam irradiation apparatus is featured by including a transport pipe which is vacuum-evacuated to be used as a transport channel of a beam taken out from an accelerator, a quadrupole magnet which modulates the beam diameter of the beam so that the beam is incident on an irradiation target existing in the atmosphere while maintaining the focusing angle of the beam, and one or more longitudinally movable range shifters which are provided to be capable of changing the distance to the irradiation target of the beam, and which modulate the beam range by reducing the energy of the beam by allowing the beam to pass through the movable range shifter, and is featured in that the beam is irradiated onto the irradiation target by modulating the beam diameter and the beam range. | 12-13-2012 |
| 20120316379 | IMAGING OBSERVATION TIMING BASED ON RADIATION TREATMENT SYSTEM ELEMENT DELAY - Systems and methods are provided for imaging observation timing based on radiation treatment system element delay. One system includes an imaging element configured to generate a first observation of an object, the first observation being generated at a first time, wherein the object is associated with a volume of interest (VOI). The system is further configured to determine a plurality of positionings of the VOI based at least in part on the first observation of the object, determine a first radiation treatment system configuration based at least in part on one or more parameters of the plurality of positionings of the VOI, configure the radiation treatment system based on the first radiation treatment system configuration, and aid in administering of radiation, by a radiation treatment system element of the radiation treatment system, to at least a portion of the patient based on the first radiation treatment system configuration. | 12-13-2012 |
| 20120316380 | Pyrazolo Piperidine Derivatives as NADPH Oxidase Inhibitors - The present invention is related to pyrazolo piperidine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase). | 12-13-2012 |
| 20120323062 | DATA PROCESSING FOR REAL-TIME TRACKING OF A TARGET IN RADIATION THERAPY - A facility for processing data is described. The facility receives a stream of digital location indications, each location indication identifying a location of a patient while undergoing radiation therapy. In response to each location indication of the string, in substantially real-time relative to the receipt of the position indication, the facility performs an action responsive to the location indication. | 12-20-2012 |
| 20120330083 | RADIOTHERAPY PHANTOM - The present invention relates to a phantom for use in the auditing or verification of a proposed radiation therapy regime for administration to a patient. The phantom comprises a housing which is shaped to simulate the anatomical shape of a human head and neck; and a radiation detector module configured to receive at least one radiation detector. The housing defines a cavity in which the radiation detector module can be removeably received such that the radiation detector module occupies a predetermined location within the simulated head and neck of the housing. Said predetermined location encompasses areas of the housing which simulate a target site to which it is proposed to administer radiation to the patient and a location of at least one organ that is susceptible to harm by administration of said radiation. | 12-27-2012 |
| 20120330084 | Neutron Source for Neutron Capture Therapy - A therapy apparatus for producing thermal neutrons at a tumor site in a patient has a plurality of fast neutron sources surrounding a moderator, a fast neutron reflecting media around the fast neutron sources, a gamma-ray and neutron shielding media surrounding the fast neutron reflecting media, and a patient chamber positioned inside the moderator. The fast neutron sources are positioned around the moderator to maximize and direct the neutron flux to said tumor site. | 12-27-2012 |
| 20120330085 | SYSTEM AND METHOD FOR CALIBRATING AND POSITIONING A RADIATION THERAPY TREATMENT TABLE - A system and method for calibrating and positioning a radiation therapy treatment table with a high degree of precision and accuracy. The treatment table includes radiographic indexing markers embedded or inlaid therein. The radiographic indexing markers can include a density different from density of the table material, or a radio-frequency or magnetic contrasting matter, something that the imaging system and detector of the radiation therapy system can detect, so that when scanned, with or without a patient or phantom on the table, the precise location of the patient treatment table in the x, y and z planes is known. This is important so that the table may be reconstructed, alone or with a phantom on it, by the radiation therapy system software, providing a very good indication of where the table top is prior to treatment. | 12-27-2012 |
| 20120330086 | Rapid Range Stacking (RRS) for Particle Beam Therapy - According to one general aspect there is a position and tracking module used for a patient position and locating a region of interest, a scanning routine module used for targeting the target voxel within the region of interest by accessing a treatment plan characterization while providing a maximum amount of dose to the target voxel, wherein the scanning routine module determines a maximum amount of dose for the target voxel in all a horizontal index in a single vertical index; and a beam delivery module used for controlling a beaming device that delivers ion particles to the target voxel within the region of interest, wherein the beam delivery module controls a power supply for a horizontal magnet and a vertical magnet by retrieving information from the scanning routine module, wherein the beam delivery module controls a power supply for an accelerator energy selection. | 12-27-2012 |
| 20130006033 | APPLICATOR FOR APPLYING A RADIOACTIVE SUBSTANCE TO A BIOLOGICAL TISSUE - An applicator for applying a radioactive substance to a biological tissue, the applicator comprising a container for receiving the radioactive substance; an application device connectable to the container, by which the substance compound can be applied to the tissue; and at least a part of a conveying device by which the radioactive substance can be supplied from the container into the application device when the application device has been connected to the container. | 01-03-2013 |
| 20130006034 | METHODS OF ENHANCING THE RESPONSE TO RADIATION IN TUMOR THERAPY USING ANTI-DLL4 ANTIBODIES - The disclosure provides methods of treating cancer, tumors, and neoplasias by administering ionizing radiation and an anti-DLL4 antibody or a DLL4-binding fragment. | 01-03-2013 |
| 20130006035 | RADIOTHERAPY PHANTOM - The present invention relates to a phantom for use in the auditing or verification of a proposed radiation therapy regime for administration to a patient. The phantom comprises a housing which is shaped to simulate the anatomical shape of a human head and neck; and a radiation detector module configured to receive at least one radiation detector. The housing defines a cavity in which the radiation detector module can be removeably received such that the radiation detector module occupies a predetermined location within the simulated head and neck of the housing. Said predetermined location encompasses areas of the housing which simulate a target site to which it is proposed to administer radiation to the patient and a location of at least one organ that is susceptible to harm by administration of said radiation. | 01-03-2013 |
| 20130006036 | CONFIGURING A RADIATION TREATMENT SYSTEM BASED ON A PLURALITY OF VOLUME OF INTEREST POSITIONING - Systems, methods, and apparatuses are provided for configuring a radiation treatment system based on a plurality of volume of interest (VOI) positioning. One system includes an imaging element configured to generate a first observation of an object, the first observation being generated at a first time, wherein the object is associated with a volume of interest (VOI), and the VOI includes a volume within a body of a patient. The system further includes determining a first positioning of the VOI based at least in part on the first observation of the object, determining a second time for the imaging element based at least in part on a positioning parameter associated with the first positioning, and a time offset, and generating a second observation of the object at the second time. | 01-03-2013 |
| 20130012754 | MICROWAVE INDUCED PHOTODYNAMIC THERAPY - A method of administering photodynamic therapy includes using a microwave frequency-sensitive light-emitting polymer as a light source to excite a administered photosensitizer to exert cytotoxicity in situ at a site containing undesired or diseased tissue. | 01-10-2013 |
| 20130018215 | ESOPHAGEAL STENT AND METHODS FOR USE OF SAME - Disclosed herein are various embodiments of esophageal stents and related methods for the treatment of esophageal dysphagia. Esophageal stents, according to the present disclosure, may have a diameter between 8 mm and 16 mm. Further, esophageal stents according to the present disclosure may have a length between 40 and 150 mm. A method, according to the present disclosure, may include the steps of placing an esophageal stent across an esophageal stricture, treating an underlying cause of the esophageal stricture, and retrieving the esophageal stent following migration of the esophageal stent. The esophageal stents of the present disclosure may be configured to avoid radial and other forces that cause undue strain and/or stretching of the esophageal tissue. | 01-17-2013 |
| 20130023714 | Medical and Imaging Nanoclusters - In one embodiment the present invention discloses a nanocluster or a nanorose composition comprising two or more closely spaced nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof and one or more stabilizers. The stabilizers are in contact with the two or more closely spaced nanoparticles to form a nanocluster composition in which the inorganic weight percentage is greater than 50% and the average size is below 300 nm, and the nanocluster composition has magnetic properties, optical properties or a combination of both. | 01-24-2013 |
| 20130023715 | TRACKING OF TUMOR LOCATION FOR TARGETED RADIATION TREATMENT - Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. Functional models can be used to accurately obtain a location of specific tissue using sensors at identifiable locations of the patient's body. Using the relative distances between the identifiable sensor locations can allow a patient to be in various positions. The functional models can be prepared using accurate pre-treatment scans, which can be taken at various body positions (e.g., rotations and/or translations). The trajectory of the beam can be measured efficiently and accurately using beam sensors attached to a beam assembly, where a model maps the beam sensor locations to a trajectory of the beam. Further, a motion model can use measurements made during treatment to obtain a time-dependent functions of the movement of the specific tissue, the change of an optimal beam trajectory over time, or the change in input commands to a beam positioner. | 01-24-2013 |
| 20130023716 | DOSE CONTROL SYSTEM AND METHOD OF CONTROLLING OUTPUT DOSE OF A RADIATION THERAPY TREATMENT SYSTEM - A dose control system for a radiation therapy treatment system. The dose control system monitors the dose output and addresses the effects of rotational dose variation and drift. | 01-24-2013 |
| 20130023717 | Bladder and/or Rectum Extender with Exchangeable and/or Slideable Tungsten Shield - A shielding device includes two elongated, parallel tubes joined at a distal portion, and a shield at least one of removably and slidably situated at the distal portion. An assembly includes an applicator configured for a treatment site, an assembly block attached to the applicator, at least one rotary unit configured to be rotatably received in the assembly block, and at least one shielding device that is configured to be movably received in a respective rotary unit. A method of using the shielding device with an applicator includes inserting the distal portion of the shielding device to a treatment site, and adjusting a position of the distal portion relative to a distal end of the applicator. | 01-24-2013 |
| 20130023718 | Method and Apparatus Pertaining to Optimizing a Radiation-Treatment Leaf-Sequence Plan - Determine first information regarding physical-movement limitations pertaining to at least one multi-leaf collimator and also determine second information regarding movement of the treatment target with respect to the given patient. Then, while optimizing a radiation-treatment leaf-sequence plan, constrain individually-planned leaf positions as a function, at least in part, of the first information, the second information, and planned positions of adjacent leaves. By one approach, the first information can comprise information regarding a speed (such as a maximum speed) at which individual leaves of the multi-leaf collimator are able to move during a treatment session. By one approach, the second information can comprise information regarding a distance (such as a maximum distance) that one or more parts of the treatment target may possibly move as compared to a presumed position used during the optimizing of the radiation-treatment leaf-sequence plan. | 01-24-2013 |
| 20130030237 | POTENTIATION OF ANTI-CANCER ACTIVITY THROUGH COMBINATION THERAPY WITH BER PATHWAY INHIBITORS - Provided herein are pharmaceutical compositions and methods of treating cancer wherein the cytotoxic activity of an anticancer agent is potentiated by the combination of base excision repair (BER) pathway inhibitors. | 01-31-2013 |
| 20130046127 | MUON MONITORING SYSTEM FOR CHARGED PARTICLE RADIATION THERAPY - A muon monitoring system for particle radiation therapy includes: a shield for a selective passing, by eliminating particles and radiation produced due to the high energy particles and radiation pulses, of the delay positrons emitted due to decay of muons stopped at a position corresponding to the Bragg peak position; a positron detector for detecting positrons from a designated direction and detecting the delay positrons passed through the shield opening by each of positron detecting plates for providing information of positron produced positions and time of delay simultaneous signals; and a control/analysis apparatus generating a delay signal at a timing delayed by a predetermined time period from a completion of irradiation of the high energy particle radiation pulses, and performing a process to generate μSR signals segmented for each positron generating position by analyzing detected results obtained by operating the positron detector for a predetermined number of times. | 02-21-2013 |
| 20130053616 | INNER GANTRY - A system includes a patient support and an outer gantry on which an accelerator is mounted to enable the accelerator to move through a range of positions around a patient on the patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach a target in the patient. An inner gantry includes an aperture for directing the proton or ion beam towards the target. | 02-28-2013 |
| 20130053617 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - A particle beam irradiation apparatus comprises a particle beam shielding member which shields a part of a particle beam which is scanned, a prompt signal detector which detects a prompt signal which is generated when the particle beam which is scanned collides with the particle beam shielding member and a signal comparison device which predicts and obtains a generation pattern of a prompt signal which is generated with a predetermined scanning pattern and stores as a signal time pattern for comparison, wherein the signal comparison device detects an abnormality of scanning of a particle beam or the particle beam shielding member by comparing a detected signal time pattern which is a time pattern of a signal which is detected by the prompt signal detector to a signal time pattern for comparison which is stored. | 02-28-2013 |
| 20130066134 | Multiplexed Radiation Therapy - A radiation system is provided comprising a single source of therapeutic radiation that is directed toward at least two treatment spaces in succession. Each treatment space houses a patient to be treated, each patient being secured generally by a separate supporting device adapted to support the patient in a generally sitting or standing or horizontal position. The x-ray source first delivers at least one beam to the first patient in the first space and then the x-ray source/patient relationship is adjusted so as to deliver an at least one beam to an at least second patient in a second space. | 03-14-2013 |
| 20130066135 | NEUTRON IRRADIATION THERAPY DEVICE - A device for irradiating cancer patients with neutrons, useful in Boron Neutron Capture Therapy, using at least one neutron emitter mounted and controlled so as to deliver a measured dose of neutrons directed at a treatment site or sites. | 03-14-2013 |
| 20130072742 | METHOD AND APPARATUS PERTAINING TO MULTI-STAGE RADIATION-TREATMENT PLAN OPTIMIZATION - A control circuit employs at least two optimization stages while developing a radiation-treatment plan. During a first optimization stage the control circuit uses a first radiation-treatment plan optimization process that employs user-selected constraints to provide general plan results. During this first optimization stage the control circuit then provides one or more opportunities for a user to modify those user-selected constraints to thereby influence the general plan results. Eventually, this first optimization stage identifies a set of resultant user-selected constraints. During the second optimization stage the control circuit then uses a second radiation-treatment plan optimization process that employs the aforementioned resultant user-selected constraints to provide an optimized radiation-treatment plan. | 03-21-2013 |
| 20130072743 | METHOD AND DEVICE FOR DETERMINING A RADIOTHERAPY TREATMENT PLAN - A radiotherapy treatment plan for irradiation of an object to be irradiated is determined. The object to be irradiated includes a number of irradiation areas and the object to be irradiated is irradiated with a number of beams from different directions. The method includes determining a number of total dose conditions. One of the number of total dose conditions is assigned to a respective one of the number of irradiation areas. The method further includes determining a number of single beam dose conditions. One of the single dose conditions is assigned to a respective one of the number of beams and a respective one of the number of irradiation areas. The method also includes determining irradiation parameters for the number of beams as a function of the number of total dose conditions and the number of single beam dose conditions. | 03-21-2013 |
| 20130072744 | Multi-Leaf Collimator for Proton Beam Therapy - A proton beam collimator comprising (a) titanium or (b) stainless steel containing no tungsten or (c) containing no tungsten or brass. The collimator comprises a multi-leaf collimator (MLC). The apparatus further comprises an integrated circuit (IC) mounted adjacent the collimator, the IC subject to exposure to atomic particles, illustratively, neutrons. | 03-21-2013 |
| 20130072745 | TRACKING REPRESENTATIONS OF INDICATOR BODY PARTS - The present invention relates to a method for tracking image sections which represent indicator body parts of a body in a process sequence of images, wherein changes in the position of the indicator body parts are used as an indicator for changes in the position of a treatment body part of the body which is to be treated using a treatment beam, said method comprising the following steps: providing advance image data which describe an advance sequence of images representing a result of an advance analysis of the body; providing process image data which describe the process sequence of images, wherein the process sequence of images represents a result of a process analysis of the body which is performed after the advance analysis; determining, on the basis of the advance image data, sub-images which undergo similar changes in position in the advance sequence; extracting, on the basis of the process image data and the determined sub-images, image sections from the images of the process sequence which have an image content which corresponds to the image content of the determined sub-images; and tracking the extracted image sections in the process sequence. | 03-21-2013 |
| 20130079579 | DEVICE AND METHOD FOR RADIATION DOSIMETRY - A method and a device for regulating a therapeutic beam directed at an object are provided. The method includes displaying at least one multidimensional image data record encompassing at least one target area of the object. The method also includes determining the treatment beam dosage directed at the at lest one target area, and recording and optionally visualizing an isoline or isosurface dependent on the treatment beam dosage in the at least one multidimensional image data record. The method includes adjusting the isoline or isosurface such that the isoline or isosurface approximates a contour of the target area as closely as possible or corresponds to the contour, and regulating the treatment beam dosage by evaluation of the adjusted isoline or isosurface. | 03-28-2013 |
| 20130085314 | AUTOMATIC TREATMENT PLANNING METHOD - The invention is directed to a data processing method of determining a treatment plan, a corresponding program and a computer running the program, the treatment plan describing a medical treatment to be carried out on a patient, the steps of the method being executed by a computer and comprising:
| 04-04-2013 |
| 20130090513 | USE OF BORIC ACID IN BORON NEUTRON CAPTURE THERAPY FOR LIVER CANCER - The present invention provides a boron drug for boron neutron capture therapy for liver cancer, which is an aqueous solution of boric acid. | 04-11-2013 |
| 20130090514 | RADIATION THERAPY APPARATUS - A radiation therapy apparatus includes a gantry having a central aperture that defines a cavity, in which a patient is positionable. The apparatus also includes a positioning device, with which the patient is positionable in the central aperture of the gantry, and a radiation head for generating therapeutic radiation. The apparatus includes an extension mechanism for the radiation head. The extension mechanism may be operated, such that in a first operating mode, the radiation head is disposable inside the gantry, such that the gantry has, on a side facing the positioning device, a front surface that constitutes a front limit of the radiation therapy apparatus toward the positioning device. In the first operating mode, the radiation head is behind the front surface viewed from the positioning device. In a second operating mode, the radiation head, viewed from the positioning device, may be moved out in front of the front surface. | 04-11-2013 |
| 20130102829 | METHOD FOR TREATING OSTEOSARCOMA BY BORON NEUTRON CAPTURE THERAPY USING BORIC ACID AS A BORON DRUG - The present invention provides a treatment of osteosarcoma by boron neutron capture therapy using boric acid as a single boron drug. | 04-25-2013 |
| 20130102830 | SYSTEM AND METHOD FOR ESTIMATING AND MANIPULATING ESTIMATED RADIATION DOSE - Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets. | 04-25-2013 |
| 20130109904 | APPARATUS AND METHOD PERTAINING TO MOVEMENT COMPENSATION DURING RADIATION TREATMENT | 05-02-2013 |
| 20130116496 | APPARATUS AND METHOD FOR RADIATION TREATMENT OF A DESIRED AREA IN THE RENAL VASCULAR SYSTEM OF A PATIENT - According to another general aspect, an apparatus for irradiating a plurality of renal nerves comprising a guidewire used to lead an elongated catheter in the human body; the enlongated catheter further comprising a plurality of lumens; the plurality of lumens further comprising a source train lumen, a hydraulic pump lumen, a guidewire lumen, and an inflator lumen; the elongated catheter is connected to the guidewire by inserting the guidewire into the guidewire lumen; the elongated catheter contains a source train within the source train lumen; the source train lumen and hydraulic pump lumen are used to push the source train to a renal vessel. | 05-09-2013 |
| 20130123565 | Quality Assurance Device and Method in Radiotherapy - The invention relates to a method of quality assurance of an apparatus for radiotherapy ( | 05-16-2013 |
| 20130123566 | RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER - Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer. | 05-16-2013 |
| 20130131422 | SYSTEMS AND METHODS FOR COMMUNICATING DOSE CALIBRATION INFORMATION - Systems and methods for communicating dose calibration information are provided. One method includes determining dose calibration information of a radiopharmaceutical at a dose calibrator. The method also includes automatically storing the dose calibration information in a memory. The method further includes communicating the stored dose calibration information to a host system. | 05-23-2013 |
| 20130131423 | Methods to detect and treat diseases - The current invention discloses methods to treat disease caused by virus infection, bacterial infection, parasites infection, autoimmune disease, disease caused by production of unwanted antibodies, sepsis as well as methods to treat cancer and methods for virus infection detection using blood purification method. The current invention provides a method to treat pathogen infection by inactivating the pathogens in the blood. During the treatment, blood is withdrawn from a patient and is separated into its plasma and cellular components. The plasma portion is treated with physical means such as UV radiation to inactivate the pathogens inside and then is returned to the patient. The current invention also provide a method to treat cancer especially to prevent tumor metastasis and tumor recurrence by removing and/or inactivating (e.g. killing) the circulating tumor cells (CTC) in the blood after removing the tumor or treating the tumor with therapeutical means. | 05-23-2013 |
| 20130131424 | Programmable Particle Scatterer For Radiation Therapy Beam Formation - Interposing a programmable path length of one or more materials into a particle beam modulates scattering angle and beam range in a predetermined manner to create a predetermined spread out Bragg peak at a predetermined range. Materials can be “low Z” and “high Z” materials that include fluids. A “high Z” and, independently, a “low Z” reservoir, arranged in series, can be used. | 05-23-2013 |
| 20130131425 | Heart Treatment Kit, System, and Method for Radiosurgically Alleviating Arrhythmia - Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy. | 05-23-2013 |
| 20130131426 | Radiosurgical Ablation of the Myocardium - The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both. | 05-23-2013 |
| 20130131427 | INTRA-ORAL DEVICE FOR PROTECTING ORAL TISSUES DURING RADIATION TREATMENT - An intra-oral device for positioning oral tissues during medical treatment, for example, radiation treatment. The device includes upper and lower dental arch members configured to engage the maxillary and mandibular teeth or edentulous arch(es) of a patient, respectively. The upper and lower dental arch members are operatively coupled to provide a dental arch assembly. A protective element to displace or depress a patient's tongue is secured at a suitable working position with respect to the dental arch assembly. In an embodiment, provision is made for three-dimensional spatial adjustment of the protective element to a desired location, at least during initial fitting and assembly. The device is then secured to allow consistent repetition of the oral tissue positioning from treatment to treatment. The protective element may be configured to engage the tongue of a patient so that the tongue may be selectively positioned for treatment and/or diagnostic procedures. | 05-23-2013 |
| 20130131428 | OPTIMIZATION PROCESS FOR VOLUMETRIC MODULATED ARC THERAPY - Systems, techniques, and processes are disclosed for implementing aperture-based optimization techniques. In one aspect, a method performed by an aperture-based radiation treatment system includes implementing a volumetric modulated arc therapy (VMAT) treatment plan by generating apertures at beam angles. Beam intensities of the generated apertures are determined, which can be used to control generation of a radiation dose in a radiation therapy. | 05-23-2013 |
| 20130131429 | METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES - Psoralen compounds of Formula (I): | 05-23-2013 |
| 20130131430 | NON-PLANAR TREATMENT BEAM CONTROL - The present invention relates to a data processing method for determining control data for controlling beam positions which beam positions describe positions which a treatment beam has or would have if emitted by a beam source, the treatment beam being for treating a treatment body part of a patient, said method constituted to be performed by a computer and comprising the steps of: • providing treatment data which comprise data on a position of the treatment body part; • providing condition data which describe: constraints on the beam positions and/or constraints on positional changes of the beam positions, wherein said constraints allow for at least a part of the beam positions to lie not in a common plane; • providing an arrangement of the beam positions on the basis of the treatment data which arrangement fulfils the condition data; • determining control data for controlling a change of a relative position of the beam source relative to the treatment body part for changing the beam positions and for controlling an emission of the treatment beam from the beam source, the determined control data being constituted to change the beam positions to follow the provided arrangement of the beam positions and to cause continuous emission of the treatment beam during a continuous change of the beam positions while the beam positions follow at least a part of the arrangement. | 05-23-2013 |
| 20130131431 | CONTROL UNIT OF RADIOTHERAPY APPARATUS AND RADIOTHERAPY APPARATUS CONTROLLING METHOD - A radiotherapy apparatus controlling method according to the present invention includes controlling an imager driving unit to move an imaging unit to a position, and to image a transmission image by the imaging unit based on a radiation emitted from a first irradiating unit; and controlling the imager driving unit to move the imaging unit to a position, and to image a transmission image based on a radiation emitted from a second irradiating unit. According to such a radiotherapy apparatus controlling method, it is not necessary to separately provide an imaging unit which images the transmission image using a first radiation emitted from the first irradiating unit and an imaging unit which images a transmission image from the radiation emitted from the second irradiating unit, and a radiotherapy apparatus can be manufactured to be cheaper. | 05-23-2013 |
| 20130137915 | FLEXIBLE ENERGY FILTER FOR ION BEAM THERAPY - An energy filter allows, particularly at lower beam energies, a determined spread of the beam energies in order to preserve the beam edges and to spread the Bragg peak at each individual beam energy. The energy filter behaves similarly to a ridge filter and spreads out the Bragg peak of a low energy proton beam (70-100 MeV) so that energy modulation of the beam can be done with steps of 5 mm in one go over the full range of 235-70 MeV. Due to its mechanical flexibility, the energy filter can be placed on the skin of the patient which minimizes the effect of scattering in the filter due to the short distance behind a layer of a plurality of metal particles within a flexible soft plastic sheet to the skin of the patient. | 05-30-2013 |
| 20130137916 | RADIOTHERAPY COMBINED WITH HYPOXIC CELL SENSITIZERS - The invention discloses a method of treating cancer in a patient, comprising administering to the patient a radiation sensitizer selected from nitroimidazoles in an amount effective to sensitize a patient to radiation and subjecting the patient to radiation therapy. In certain embodiments the radiation sensitizer is etanidazole or doranidazole. | 05-30-2013 |
| 20130144104 | RADIATION SYSTEMS WITH MINIMAL OR NO SHIELDING REQUIREMENT ON BUILDING - A radiation system includes a support, a capsule rotatably coupled to the support, a radiation source movably coupled to the capsule, wherein the radiation source is configured to provide a treatment radiation beam, and is capable of being turned on or off in response to a control signal, and a collimator located next to the radiation source, wherein the capsule defines a space for accommodating a portion of a patient, and includes a shielding material for attenuating radiation resulted from an operation of the radiation source, and wherein the shielding material is configured to limit a radiation exposure level to 5 mR/hr or less within 3 meters from an isocenter. | 06-06-2013 |
| 20130150645 | METHOD AND DEVICE FOR REGISTRATION AND IMMOBILIZATION - Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses. | 06-13-2013 |
| 20130150646 | Method for the Operation of a Radiotherapy System and a Radiotherapy System - A method for calculating local part radiation doses in a radiotherapy system for applying a total radiation dose in a target volume with several beams is provided. The method includes determining at least one first control plane for controlling the dosing of the beams, determining at least one second control plane for controlling the positioning of the beams, and allocating beams to the first and second control planes. The method also includes, for at least one side of a first control plane, calculating in isolation of the corresponding local part radiation doses of all the beams allocated to the first control plane. | 06-13-2013 |
| 20130150647 | Irradiation Planning for Particle Therapy - A method for producing an irradiation plan for a target volume includes preparing a modulation curve that characterizes modulation of particle numbers at target points in the target volume that lie one behind another in a direction of the beam. The method also includes determining a current position of the target volume and defining a plurality of target points that fully cover the target volume in the current position. Particle numbers are assigned to the plurality of current target points using the modulation curve. | 06-13-2013 |
| 20130150648 | INCLINED BEAMLINE MOTION MECHANISM - A radiotherapy particle emitter positioning device is provided. The positioning device includes first and second arcuate support frames, a mounting carriage and a drive arrangement. The first and second arcuate support frames each include a drive track arrangement defining an arcuate carriage guide path. The mounting carriage is configured for supporting the radiotherapy particle emitter. The mounting carriage is mounted to and supported by the support frames. The mounting carriage is connectable to the drive track arrangements and moveable along the carriage guide path. The mounting carriage also includes the drive arrangement. The drive arrangement engages the drive track arrangements for driving the mounting carriage along the drive track arrangements and the carriage guide path. | 06-13-2013 |
| 20130150649 | SENSITIZATION OF TUMOR CELLS TO RADIATION THERAPY THROUGH ADMINISTRATION OF ENDOTHELIN AGONISTS - Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ET | 06-13-2013 |
| 20130158336 | USE OF NANOPARTICLES IN THE PHOTODYNAMIC TREATMENT OF TUMORS AND NON-DESTRUCTIVE TESTING - A method for generating light intensity inside a tumor to aid in the treatment of diseases such as cancer is disclosed. The light is generated inside the body to perform a modified photodynamic therapy treatment (PDT) that allows treatment of body regions that are inaccessible by normal PDT procedures. In addition, the use of two spatially and temporally coincident treatment modalities, i.e. radiation and PDT, have the potential for significant biological synergy in the tumor. | 06-20-2013 |
| 20130158337 | METHOD AND DEVICE FOR PREVENTING OR TREATING ATOPIC DERMATITIS - A method for preventing or treating atopic dermatitis of a patient by covering the patient itself or a patient's area affected by the atopic dermatitis, filling a covered space with positive ions composed of H | 06-20-2013 |
| 20130165731 | APPARTUS AND METHOD TO VISUALLY VIEW HIGH-DOSE-RADIATION APPARATUS USED TO VERIFY QUALITY ASSURANCE - An apparatus for testing a high-dose-rate afterloader machine comprising an image capturing device that used to capture a plurality of still images or a real-time video, wherein said image capturing device further comprises, a zoom lens, a microphone and a light, a measurement ruler that is located on a base plate; a plurality of calibration points located on the said base plate, a source insert that connects to said high-dose-rate afterloader machine to one end, wherein said source insert allows entry of a radioactive pellet and a source wire into one end, and an adjustable shaft that is connected to said base plate and connected to said image capturing device. | 06-27-2013 |
| 20130165732 | METHOD AND SYSTEM FOR ADMINISTERING RADIOPHARMACEUTICAL THERAPY (RPT) - A computerized system and method for determining an optimum amount of radiopharmaceutical therapy (RPT) to administer, comprising: performing processing associated with obtaining activity image information related to at least one agent for sub-units of at least one imaged organ from at least one detector; performing processing associated with running at least one calculation for the activity image information, using at least one computer application, to obtain absorbed dose rate image information; and performing processing associated with adding the absorbed dose rate image information, using, the at least one computer application, to obtain RPT total absorbed dose image information for the at least one imaged organ; wherein macroscopic distribution measurements that are related to microscopic or sub-unit distribution of the at least one agent are utilized. | 06-27-2013 |
| 20130172656 | NOVEL USE OF ARMILLARIDIN FOR TREATING CANCER - Novel Uses of an aromatic ester isolated from | 07-04-2013 |
| 20130172657 | INTEGRATED RADIATION THERAPY SYSTEMS AND METHODS FOR TREATING A TARGET IN A PATIENT - An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy. | 07-04-2013 |
| 20130172658 | POSITRON EMITTER IRRADIATION SYSTEM - Analysis of the production of | 07-04-2013 |
| 20130178688 | SEQUENCING SECTOR FIELDS - A method for planning a treatment session of a patient and optimizing the treatment time for a treatment using a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. During an optimization of a treatment plan for a patient, a set of shots to be delivered to a plurality of isocenter positions within a target volume of a patient during a treatment session are determined and a beam-on time for each respective sector and state for each isocenter during which radiation is to be delivered are determined based on the treatment plan. For each isocenter position, sectors and states of respective sector are grouped in accordance predetermined rules with respect to beam-on times for respective state of the sectors, wherein sectors and respective states are aggregated for simultaneous delivery of radiation during a predetermined period of time. | 07-11-2013 |
| 20130178689 | TARGETS FOR GENERATING IONS AND TREATMENT APPARATUSES USING THE TARGETS - Provided is an ion beam treatment apparatus including the target. The ion beam treatment apparatus includes a substrate having a first surface and a second surface opposed to the first surface, and including a cone type hole decreasing in width from the first surface to the second surface to pass through the substrate, wherein an inner wall of the substrate defining the cone type hole is formed of a metal, an ion generation thin film attached to the second surface to generate ions by a laser beam incident into the cone type hole through the first surface and strengthen, and a laser that emits a laser beam to generate ions from the ion generation thin film and project the ions onto a tumor portion of a patient. The laser beam incident into the cone type hole is focused by the cone type hole and is strengthened. | 07-11-2013 |
| 20130178690 | RADIOTHERAPY APPARATUS CONTROLLER AND RADIOTHERAPY APPARATUS CONTROL METHOD - A radiotherapy apparatus control method includes: collecting a planning-stage position where a patient is arranged during a planning stage; collecting a position-adjusting-stage position where the patient is arranged during a position-adjusting stage; calculating a treatment-stage position, a gantry-angle offset value and a ring-angle offset value such that an orientation in which an irradiation head is arranged with respect to the treatment-stage position, when a ring is arranged while deviating from a ring angle by the ring-angle offset value and a gantry is arranged while deviating from a gantry angle by the gantry-angle offset value, coincides with an orientation in which the irradiation head is arranged with respect to the planning-stage position, when the ring is arranged at the ring angle and the gantry is arranged at the gantry angle. After that, the patient is arranged at a patient position. | 07-11-2013 |
| 20130184511 | Radiosurgical Neuromodulation Devices, Systems, and Methods for Treatment of Behavioral Disorders by External Application of Ionizing Radiation - Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased. | 07-18-2013 |
| 20130184512 | CHARGED PARTICLE BEAM IRRADIATION DEVICE - A charged particle beam irradiation device includes a particle accelerator that accelerates charged particles and ejects a charged particle beam, a cylindrical outer shell part that is capable of rotating around a rotating axis, an irradiation unit that is capable of irradiating an irradiation target with the charged particle beam, the irradiation direction of which changes in accordance with the rotation of the outer shell part, and a beam transport line that transports the charged particle beam ejected from the particle accelerator to the irradiation unit. The particle accelerator and the beam transport line may be at least partially housed within the outer shell part. | 07-18-2013 |
| 20130184513 | SKIN CARE METHOD AND SKIN CARE DEVICE - A skin care method using a closed-bottomed casing | 07-18-2013 |
| 20130190548 | BEAM POSITION MONITOR AND PARTICLE BEAM THERAPY SYSTEM - A charged particle beam position monitor is provided with a plurality of position monitors and a beam data processing device that performs calculation processing of the state of a charged particle beam, based on a plurality of signals outputted from the position monitors. The beam data processing device includes a plurality of channel data conversion units that perform AD conversion processing of the plurality of signals outputted from the position monitors; a position size processing unit, for each of the position monitors, that calculates the beam position of the beam, based on voltage information obtained through the AD conversion processing; and an integrated control unit that controls the plurality of channel data conversion units in such a way that while the beam is irradiated onto an irradiation subject, AD conversion processing of the signals is performed at different timings for the respective position monitors. | 07-25-2013 |
| 20130197294 | METHOD AND APPARATUS PERTAINING TO CONFIGURING A RADIATION-DELIVERY TREATMENT PLAN - A radiation-delivery treatment plan includes a first value for a limit as pertains to motion compensation-based adjustment of a radiation-delivery parameter during a first portion of a radiation treatment session as well as a second value for that same limit during a second, different portion of the treatment session. By one approach, the radiation-delivery treatment plan selects between this first and second value as a function of a preselected parameter. Examples of such parameters include, but are not limited to, radiation-beam orientation parameters (such as a gantry-based parameter) and/or any of a variety of external surrogates. | 08-01-2013 |
| 20130204067 | Method and Apparatus Pertaining to the Optimization of Radiation-Treatment Plans Using Automatic Changes to Treatment Objectives - Optimization of a radiation-delivery treatment plan can be facilitated by permitting the making of automatic changes to one or more treatment objectives. This can comprise processing radiation-delivery treatment plan parameters with respect to one or more predetermined treatment objectives and then automatically changing that predetermined treatment objective to provide one or more changed treatment objectives (including altered, deleted, and/or added treatment objectives) that can then be used to at least attempt to optimize a radiation-delivery treatment plan. That predetermined treatment objective can comprise, for example, a treatment objective as regards a given treatment volume. The automatic changing of the predetermined treatment objective can occur in response to a variety of stimuli such as detecting a change with respect to a treatment condition such as a change in the presentation of a patient volume of interest. | 08-08-2013 |
| 20130204068 | Apparatus and Methods For Treating Pulmonary Hypertension - A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension. | 08-08-2013 |
| 20130204069 | Compositions and Methods of Treating Tumors - Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed. | 08-08-2013 |
| 20130217946 | CHARGED PARTICLE TREATMENT, RAPID PATIENT POSITIONING APPARATUS AND METHOD OF USE THEREOF - The invention comprises a charged particle beam, rapid patient positioning system including steps of: positioning a patient relative to a table in a substantially vertical orientation, optionally constraining motion of the patient with one or more constraints, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and table in a substantially horizontal orientation, such as in a position for tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. Optionally, the robot arm is used to re-orientate the patient into a substantially vertical orientation at the conclusion of a charged particle therapy session. | 08-22-2013 |
| 20130217947 | Hybrid Ultrasound-Guided Superficial Radiotherapy System and Method - Systems, method and devices for detecting, analyzing and treating lesions, such as skin cancer are disclosed. Such a system can include a high-frequency ultrasound imaging device to image a lesion. The system can also include a processor that executes instructions stored in memory to perform operations, and the operations can include receiving a plurality of images of the lesion from the high-frequency ultrasound imaging device, rendering a three dimensional model of the lesion using the plurality of images from the high-frequency ultrasound imaging device and determining a treatment dosimetry based on the three dimensional model of the lesion. The system can also include a radiotherapy device to provide radiotherapy treatment to the lesion, where the radiotherapy treatment is based on the treatment dosimetry. | 08-22-2013 |
| 20130217948 | Advanced Radiotherapy Treatment Planning Optimization - A method of radiotherapy treatment planning is described. A planned target volume is identified for radiotherapy treatment and at least one volume of interest is identified. The mass, density, and total deposited energy contained in the planned target volume and the volumes of interest are identified and dose objectives are determined. At least one of the objectives is a function of the identified mass, density, or deposited energy. A composite objective function is determined using the dose objectives for the planned target volume and the volumes of interest. A near optimal solution to the composite objective function is determined to produce a radiotherapy treatment plan. | 08-22-2013 |
| 20130217949 | COMBINATORIAL METHODS AND COMPOSITIONS FOR TREATMENT OF MELANOMA - The invention relates to combining targeted therapies with selected chemotherapeutics for the treatment of melanoma. The invention provides a method for inducing apoptosis in a melanoma tumor cell by reducing Akt3 activity, a method for inducing apoptosis in a melanoma tumor cell comprising contacting a melanoma tumor cell with an agent that reduces Akt3 activity to restore normal apoptotic sensitivity to a melanoma tumor cell, allowing a lower concentration of chemotherapeutic agents resulting in decreased toxicity to a patient. Also disclosed is a method for treating a melanoma comprising administering an agent that reduces Akt3 activity and an agent that reduces V599E B-Raf activity, thereby treating a melanoma tumor. | 08-22-2013 |
| 20130217950 | THERAPEUTIC APPARATUS FOR HEATING A SUBJECT - A therapeutic apparatus ( | 08-22-2013 |
| 20130217951 | 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES - Compounds of the formula (I), in which R | 08-22-2013 |
| 20130225900 | Method and Device for Closure of Intraluminal Perforations - A closure device having evertable arms for capturing and everting tissue and method for its use with an invasive scope, such as an endoscope, for full-thickness closure of perforations and leaks in the walls of an intraluminal bodily space. | 08-29-2013 |
| 20130231516 | Pluridirectional Very High Electron Energy Radiation Therapy Systems and Processes - A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy. In addition to the unique physical advantages of extremely rapid radiation delivery, there may also be radiobiological advantages in terms of greater tumor or other target control efficacy for the same physical radiation dose. | 09-05-2013 |
| 20130231517 | BEAM MONITOR SYSTEM AND PARTICLE BEAM IRRADIATION SYSTEM - Disclosed is a beam monitor system in which signals outputted from a plurality of wires are divided in a multi-wire type monitor for measuring a beam profile of a charged particle beam, an identical number of the wires are grouped, the signals of the respective groups are taken out one piece by one piece to be connected with each other, and the number of the pieces, corresponding to a number of the wires belonging to the one group, are put together to be connected to a signal processor storing connection information. | 09-05-2013 |
| 20130231518 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY - Embodiments of the present invention provide compounds and compositions thereof, which are effective for mitigating tissue damage or lethality induced by an agent, and methods of making and using the same. | 09-05-2013 |
| 20130231519 | 1H-Pyrrolo[2,3 b]pyridine derivatives - 1H-Pyrrolo[2,3-b]pyridine compounds are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours. | 09-05-2013 |
| 20130245354 | Automated method and apparatus for the verification of treatment parameters prior to delivery of radiaiton to patient - Prior to delivery of the radiation treatment, the actual treatment parameters need to be verified against the parameters in a treatment planning system. This verification (timeout) is performed manually by radiation technologist(s) as shown in FIG. | 09-19-2013 |
| 20130245355 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS - Compounds of the formula I in which Q, R | 09-19-2013 |
| 20130253251 | Eyelid Plaque - An eyelid plaque and a method of using the plaque to treat eye cancers. The eyelid plaque is placed on the eyelid such that it defines an enclosure within which the radiation source resides. The enclosure defines a radiation shield that reduces radiation entering other organs and structures proximate the cancer being treated. | 09-26-2013 |
| 20130253252 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - The objective of the present invention is to eliminate noise caused by driving a ridge filter and to achieve a uniform dose distribution without making a patient sense discomfort or anxiety. There are provided a ridge filter having a thickness distribution in which the energy that a charged particle beam loses differs depending on the position thereon through which the charged particle beam passes, a deflector that deflects the charged particle beam, and a controller that controls the deflector in such a way that the charged particle beam passes through the thickness distribution of the ridge filter. | 09-26-2013 |
| 20130253253 | PARTICLE BEAM THERAPY SYSTEM - There are provided with a respiration induction apparatus that induces respiration, based on a desired respiration waveform; a switching device that switches the orbit of a particle beam; and an irradiation apparatus that controls irradiation, in synchronization with the desired respiration waveform. A controller, which performs synchronization control of the switching device and the respiration induction apparatuses in a plurality of treatment rooms, adjusts the periods and the phases of the desired respiration waveforms of the respiration induction apparatuses in the treatment rooms so that the irradiation times synchronized with the desired respiration waveforms in the treatment rooms do not overlap with one another, and controls the switching device so as to switch the orbits of the particle beam, in accordance with the respective irradiation times of the treatment rooms. | 09-26-2013 |
| 20130261368 | NON-INVASIVE AND MINIMALLY INVASIVE AND TIGHTLY TARGETED MINIMALLY INVASIVE THERAPY METHODS AND DEVICES FOR PARATHYROID TREATMENT - Systems and method for treating organic tissue of a patient's body in precisely controlled regions of the body such as the parathyroid glands. The systems and methods include introducing an energy or substance into contact with target tissue to control functionality of the target tissue and preventing the energy or substance from contacting surrounding non-target tissues sufficiently that functionality of critical non-target tissues is substantially not affected. | 10-03-2013 |
| 20130261369 | TARGET FOR GENERATING ION AND TREATMENT APPARATUS USING THE SAME - Provided are an ion generation target and a treatment apparatus using the same. The treatment apparatus includes an ion generation material generating the ions by incident laser beam, the ion generation material generating a bubble having a hemispheric shape, a support supporting the bubble having the hemispheric shape, a bubble generation member for generating the bubble having the hemispheric shape on the support by using the ion generation material, and a laser radiating laser beam onto a surface of the bubble to generate ions from the ion generation material, thereby projecting the ions onto a tumor portion of a patient. | 10-03-2013 |
| 20130261370 | RADIO-IMMUNO-MODULATION TREATMENT FOR ADVANCED CANCER AND MONITORING TOLERANCE AND CELLULAR IMMUNE RESPONSE AT THE TUMOR SITE - A combination therapy for treating advanced cancer, comprises, first, performing targeted low dose radiation therapy on a recipient tumoral site to generate an inflammation zone and an immuno-stimulant effect, including release of cytokines and chemokines. Secondly, PMBC collected from a suitable donor are administered intravenously in order to initiate an allogeneic reaction. The post-radiotherapy inflammation zone will attract the newly injected PBMC to the tumor bed, triggering an immunological cancer cell rejection. The cellular response in the recipient is monitored and post-treatment evaluation for recipients' side effects is also provided. | 10-03-2013 |
| 20130267755 | High-Speed Tumor Segmentation System - A system for automatic segmentation of tumor tissue, useful for motion correction during radiotherapy using real-time imaging, identifies multiple regions based on the values of data and then identifies the tumors within the regions based on a priori knowledge about tumor size and/or location. The regions may be refined with robust and fast morphological operations, providing segmentation at speeds commensurate with the motion to be corrected. | 10-10-2013 |
| 20130267756 | PARTICLE THERAPY SYSTEM - A particle therapy system is capable of reducing an increase in treatment time caused by the initialization operation of magnets in the execution of the scanning irradiation method successively changing the energy level of a beam extracted from an accelerator. An irradiation control apparatus has a scheme that calculates setting vales of excitation current for bending magnets for a transport system on every irradiation condition (energy condition), and sets appropriate excitation current values according to the irradiation sequence. The irradiation control apparatus | 10-10-2013 |
| 20130267757 | ANTHRAQUINONES FOR USE AS RADIOSENSITIZERS IN CANCER TREATMENT - Provided is an a combination therapy including a radiosensitizing agent and radiation, and being effective to inhibit proliferation of cancer stem cells. Further provided is a combination which includes a radiosensitizing agent and radiation, and effectively reduces incidence of at least one of cancer relapse and metastatic cancer in a subject having a cancer, wherein the cancer includes cancer stem cells. Also provided are anthraquinone derivatives for use as radiosensitizing agents in combination with radiations, the combination therapy being cancer specific. Further, the radiosensitizing agents were found to be cancer specific, namely, some being more effective against a cancer type as compared to others. | 10-10-2013 |
| 20130274536 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - When IMRT technology for a radiation therapy system utilizing an X-ray or the like is applied to a particle beam therapy system having a conventional wobbler system, it is required to utilize two or more boluses. The present invention solves the problem of excess irradiation in IMRT by a particle beam therapy system. More specifically, the problem of excess irradiation in IMRT by a particle beam therapy system is solved by raising the irradiation flexibility in the depth direction, without utilizing a bolus. A particle beam irradiation apparatus has a scanning irradiation system that performs scanning with a charged particle beam accelerated by an accelerator and is mounted in a rotating gantry for rotating the irradiation direction of the charged particle beam. The particle beam irradiation apparatus comprises a columnar-irradiation-field generation apparatus that generates a columnar irradiation field by enlarging the Bragg peak of the charged particle beam. | 10-17-2013 |
| 20130274537 | APPARATUS AND METHOD FOR EVALUATING A RADIATION THERAPY PLAN - The present invention relates to an apparatus and method for evaluating the safety of RTP data. According to an embodiment of the present invention, the computer-implemented method for evaluating safety of RTP data comprises the steps of: receiving first RTP data about a first concerned area of a patient; receiving a second concerned area of the patient from a user; and calculating an amount of radiation for the second concerned area by using the first RTP data and a medical image of the patient. The evaluating method of the present invention may further comprise a step of evaluating the safety of the first RTP data by using information on the amount of radiation for the second concerned area. | 10-17-2013 |
| 20130274538 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - The particle beam irradiation apparatus comprises: a position monitor that detects a passing position of a charged particle beam; and an irradiation control apparatus that calculates a distance from a predetermined reference point to the position monitor, calculates a beam irradiation position on an irradiation subject, and controls irradiation of the beam; wherein the irradiation control apparatus includes a position calculation apparatus that calculates the beam irradiation position, based on a beam position detected by the position monitor, a scanning starting point distance information on a distance from a irradiation plane of the irradiation subject to a scanning starting point, of the beam, in a scanning electromagnet, and a position monitor distance information on a distance, from the irradiation plane to the position monitor, that is calculated based on the calculated distance. | 10-17-2013 |
| 20130274539 | RADIATION THERAPY DEVICE CONTROLLER, PROCESSING METHOD AND PROGRAM FOR SAME - This radiation therapy device controller selects, for a plurality of body motion phases, computed tomography image data obtained which shows a diseased portion, and generates, for each rotation angles of a ray source and a sensor array, a reconstructed image. The control device generates a radiation projection image which shows the diseased portion when the radiation is radiated if the rotation angle is a predetermined rotation angle, compares the reconstructed image of each of the plurality of body motion phases with the radiation projection image, and determines a body motion phase indicated by a reconstructed image in which a difference is small, to be a current respiratory phase. As a result, a position of the diseased portion calculated for the computed tomography image data in the computed tomography image data group of the respiratory phase in advance is identified to be a current position of the diseased portion. | 10-17-2013 |
| 20130281758 | Treatment of refractory neuropsychiatric disorders using targeted radiation - Provided herein are methods for treating neuropsychiatric disorders by delivering radiation to an area in the subgenual anterior cingulate cortex, particularly to the cingulate area 25. Those methods are also beneficial to treat refractory neuropsychiatric disorders. | 10-24-2013 |
| 20130289330 | PARTICLE BEAM ROTATIONAL IRRADIATION APPARATUS - The particle beam rotational irradiation apparatus is provided with an irradiation nozzle that irradiates a charged particle beam, a beam transport unit that transports the charged particle beam to the irradiation nozzle, and a rotating unit that can rotate around the isocenter; the particle beam rotational irradiation apparatus is characterized in that the beam transport unit has three or more bending electromagnets and in that the bending electromagnets are arranged in such a way that in the case where as a pair of bending planes, any two of the bending planes of the bending electromagnets are selected, the two bending planes of at least one pair of bending planes are not on the same plane, not parallel with each other, and not perpendicular to each other. | 10-31-2013 |
| 20130289331 | TARGETS FOR GENERATING IONS AND TREATMENT APPARATUSES INCLUDING THE TARGETS - Provided are an ion generation target and a treatment apparatus including the target. The treatment apparatus includes a grid having a net shape of nano wires, an ion generation thin film attached to a side of the grid and generating ions by means of an incident laser beam, and a laser for emitting a laser beam into the nano wire of the grid to generate ions from the ion generation thin film and project the ions onto a tumor portion of a patient. The laser beam emitted into the nano wire forms a near field, the intensity of which is higher than that of the laser beam through a nanoplasmonics phenomenon, and the near field emits the ions from the ion generation thin film. | 10-31-2013 |
| 20130289332 | METHODS AND SYSTEMS FOR AUTOMATED PLANNING OF RADIATION THERAPY - Methods and systems for automated treatment planning for radiation therapy are disclosed. Such methods and systems may be useful for treatment planning for intensity-modulate radiotherapy (IMRT). Also provided are user interfaces for automated radiation therapy treatment planning. | 10-31-2013 |
| 20130289333 | PARTICLE BEAM THERAPY SYSTEM - The present invention is intended to enable proper elimination of the remanent magnetization of the scanning magnet, which is used in a particle beam therapy system, in a short time. In the particle beam therapy system that irradiates an irradiation target with a particle beam | 10-31-2013 |
| 20130303823 | EyeLid Plaque - An eyelid plaque and a method of using the plaque to treat eye cancers. The eyelid plaque is placed on the eyelid such that it defines an enclosure within which the radiation source resides. The enclosure defines a radiation shield that reduces radiation entering other organs and structures proximate the cancer being treated. | 11-14-2013 |
| 20130303824 | SYSTEM AND METHOD FOR AUTOMATED CYCLOTRON PROCEDURES - Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters. | 11-14-2013 |
| 20130303825 | METHOD AND APPARATUS FOR PRODUCING IRRADIATION PLANNING - A method for drawing up an irradiation plan includes at least one of calculating, assessing, displaying and taking into consideration effects of at least one uncertainty on the irradiation plan, at least one of at times and in certain areas. | 11-14-2013 |
| 20130303826 | PROGNOSTIC SIGNATURE FOR ORAL SQUAMOUS CELL CARCINOMA - The present disclosure describes methods and compositions for diagnosing or predicting likelihood of a OSCC recurrence in a subject having undergone OSCC resection comprising: a) determining an expression level of one or more biomarkers selected from Table 4, 5 and/or 7, optionally MMP1, COL4A1, THBS2 and/or P4HA2 in a test sample from the subject, the one or more biomarkers comprising at least one of THBS2 and P4HA2, and b) comparing the expression level of the one or more biomarkers with a control, wherein a difference or a similarity in the expression level of the one or more biomarkers between the test sample and the control is used to diagnose or predict the likelihood of OSCC recurrence in the subject In particular, the present disclosure describes methods and compositions using a four-gene biomarker signature that can predict recurrence of oral squamous cell carcinoma in subjects that have histologically normal surgical resection margins. | 11-14-2013 |
| 20130310625 | VELIPARIB IN COMBINATION WITH WHOLE BRAIN RADIATION THERAPY FOR THE TREATMENT OF BRAIN METASTASES - The invention relates to a method for the treatment of brain metastases from non-small cell lung cancer in a subject, comprising administering to the subject an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, in combination with an effective amount of whole brain radiation. | 11-21-2013 |
| 20130317275 | IMPLANT FOR TARGETING THERAPEUTIC PROCEDURE - An implantable device has a body that is substantially rigid and has a predetermined shape. The body is further bioabsorbable and has a density less than or equal to about 1.03 g/cc. When the device is implanted in a resected cavity in soft tissue, it causes the cavity to conform to the predetermined shape. The implantable device is further imageable due to its density being less than that of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined. | 11-28-2013 |
| 20130324783 | Apparatus and Method Pertaining to Optimizing a Radiation-Treatment Plan Using Historical Information - A control circuit operably couples to a memory having historical information stored therein. This historical information comprises information regarding delivered radiation doses to non-targeted patient volumes for a plurality of different volume presentations. The control circuit iteratively optimizes a radiation-treatment plan for a specific plan using that historical information. The aforementioned historical information can comprise delivered-dose metrics as correspond to different relative distances within given patients. The control circuit can employ such information to determine, for example, an estimated dosage (including, if desired, a corresponding range of estimated dosages) for at least one volume within the specific patient at a specific distance from a specific point of reference. The control circuit can compare such historical information against radiation-treatment plan optimization results to qualitatively assess the radiation-treatment plan optimization results. | 12-05-2013 |
| 20130324784 | METHOD AND A SYSTEM FOR OPTIMIZING A RADIATION TREATMENT PLAN - A computer-based method for generating an improved radiation therapy treatment plan for a treatment volume having a target and an organ-at-risk. The method includes a step of accessing an existing radiation therapy treatment plan from a memory of a computer, a dose distribution of the existing radiation therapy treatment plan serving as a reference dose distribution; and performing machine parameter optimization on the existing radiation therapy treatment plan with the computer by pursuing an optimization goal to minimize doses to the organ-at-risk, thereby generating the improved radiation therapy treatment plan. | 12-05-2013 |
| 20130324785 | METHOD AND APPARATUS FOR PLANNING OR CONTROLLING A RADIATION TREATMENT - The present invention relates to method for generating planning data or control data for a radiation treatment, comprising the following steps: acquiring segmented data of an object which contains a treatment volume and a non-treatment volume; modelling at least some or all of the volume or surface of the treatment volume as a source of light or rays exhibiting a predefined or constant initial intensity; modelling the non- treatment volume as comprising volumetric elements or voxels which each exhibit an individually assigned feature or attenuation or transparency value (t | 12-05-2013 |
| 20130338422 | ANTICANCER PRODRUG ACTIVATED BY RADIATION OR ULTRAVIOLET TREATMENT AND USE THEREOF - The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy. | 12-19-2013 |
| 20130345489 | CONFIGURATION MANAGEMENT AND RETRIEVAL SYSTEM FOR PROTON BEAM THERAPY SYSTEM - In a complex, multi-processor software controlled system, such as proton beam therapy system (PBTS), it may be important to provide treatment configurable parameters that are easily modified by an authorized user to prepare the software controlled systems for various modes of operation. This particular invention relates to a configuration management system for the PBTS that utilizes a database to maintain data and configuration parameters and also to generate and distribute system control files that can be used by the PBTS for treatment delivery. The use of system control files reduces the adverse effects of single point failures in the database by allowing the PBTS to function independently from the database. The PBTS accesses the data, parameters, and control settings from the database through the system control files, which insures that the data and configuration parameters are accessible when and if single point failures occur with respect to the database. | 12-26-2013 |
| 20130345490 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - A scanning power source that outputs the excitation current for a scanning electromagnet and an irradiation control apparatus that controls the scanning power source; the irradiation control apparatus is provided with a scanning electromagnet command value learning generator that evaluates the result of a run-through, which is a series of irradiation operations through a command value for the excitation current outputted from the scanning power source, that updates the command value for the excitation current, when the result of the evaluation does not satisfy a predetermined condition, so as to perform the run-through, and that outputs to the scanning power source the command value for the excitation current such that its evaluation result has satisfied the predetermined condition. | 12-26-2013 |
| 20140005463 | ASSEMBLY AND METHOD FOR CONFORMAL PARTICLE RADIATION THERAPY OF A MOVING TARGET | 01-02-2014 |
| 20140005464 | STUDYING DOSIMETRIC IMPACT OF MOTION TO GENERATE ADAPTIVE PATIENT-SPECIFIC MARGINS IN EBRT PLANNING | 01-02-2014 |
| 20140012061 | NON-INVASIVE LOCATION AND TRACKING OF TUMORS AND OTHER TISSUES FOR RADIATION THERAPY - Embodiments herein provide a non-invasive tracking system that accurately predicts the location of tumors, such as lung tumors, in real time, while allowing patients to breathe naturally. This is accomplished by using Electrical Impedance Tomography (EIT), in conjunction with spirometry, strain gauge and infrared sensors, and by using sophisticated patient-specific mathematical models that incorporate the dynamics of tumor motion. With the direction and speed of lung tumor movement successfully tracked, radiation may be effectively delivered to the lung tumor and not to the surrounding healthy tissue, thus increased radiation dosage may be directed to improving local tumor control without compromising functional parenchyma. | 01-09-2014 |
| 20140012062 | HADRON TREATMENT PLANNING WITH ADEQUATE BIOLOGICAL WEIGHTING - Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region. | 01-09-2014 |
| 20140018602 | APPARATUS AND METHOD PERTAINING TO DETERMINING A SPATIALLY-VARIANT NORMAL TISSUE CONSTRAINT AS A FUNCTION OF DOSE DISTRIBUTION - A control circuit optimizes a radiation-treatment plan (as regards treating at least one target volume for a given patient) by automatically determining a spatially-variant normal tissue constraint as a function, at least in part, of dose distribution for normal tissue that is proximal to the target volume. If desired, the control circuit can repeatedly determine spatially-variant normal tissue constraints while optimizing the radiation-treatment plan. This automatic determination can comprise evaluating dose distributions at specific different distances from the target volume. So configured, the control circuit can effect such evaluation by penalizing, during the optimization of the radiation-treatment plan, dose distribution levels that exceed a predetermined distribution property (such as an aggregation value for the dose values including, but not limited to, an average value of dose values for each of the given specific different distances) at a given one of the specific different distances. | 01-16-2014 |
| 20140018603 | CHARGED PARTICLE BEAM TREATMENT PLANNING DEVICE AND CHARGED PARTICLE BEAM TREATMENT PLANNING METHOD - There is provided a charged particle beam treatment planning device that creates a treatment plan and is connected to a charged particle beam irradiation apparatus that includes a scanning electromagnet, which scans a charged particle beam, and a degrader, which adjusts a range of the charged particle beam by reducing the energy of the charged particle beam, and irradiates an irradiation object with the charged particle beam. The charged particle beam treatment planning device includes a control unit that adjusts the dose of the charged particle beam, which is irradiated to a predetermined position of the irradiation object, on the basis of a passing distance of the charged particle beam within the degrader calculated using a deflection angle of the charged particle beam. | 01-16-2014 |
| 20140018604 | MOVING OBJECT TRACKING SYSTEM FOR RADIOTHERAPY - In the case where X-ray tubes and X-ray detectors have fixed directions (directions of irradiation and directions of detecting planes), X-ray fluoroscopy can be carried out from various directions by providing two U-shaped tracks for the X-ray tubes and the X-ray detectors, each having two straight tracks arranged opposite each other, and a curved track connected thereto. An increased number of directions for X-ray fluoroscopy can be secured by arranging a U-shaped track rail for the X-ray tubes and a U-shaped track rail for the X-ray detectors opposite each other when seen in plane view. | 01-16-2014 |
| 20140031602 | TREATMENT PLANNING SYSTEM - A treatment planning system is provided which, with irradiation parameters varied over time, performs highly accurate dose distribution calculations based on information about tumor movements included in 4D CT images. The system is characterized by the ability to read CT images furnished with timing information and associate the status of the irradiation target corresponding to an elapsed time from the beginning of irradiation with positions being irradiated at corresponding elapsed time points so as to calculate the dose distribution. | 01-30-2014 |
| 20140031603 | METHODS AND APPARATUS FOR IMAGING IN CONJUNCTION WITH RADIOTHERAPY - Methods and apparatus for planning imaging include planning imaging in conjunction with planning a radiation treatment. A radiation dose due to planned imaging may be calculated and used in optimizing a plan for delivering therapeutic radiation. Imaging and treatment may be performed using radiation beams having different characteristics. In some embodiments an imaging beam is generated using a low-Z target and a therapy beam is generated using a high-Z target. A radiation treatment planning system may include data characterizing both the imaging beam and the treatment beam. | 01-30-2014 |
| 20140046113 | TREATMENT PLANNING SYSTEM, DEVICE FOR CALCULATING A SCANNING PATH AND PARTICLE THERAPY SYSTEM - In a particle therapy treatment planning system for creating treatment plan data, the movement of a target (patient's affected area) is extracted from plural tomography images of the target, and the direction of scanning is determined by projecting the extracted movement on a scanning plane scanned by scanning magnets. Irradiation positions are arranged on straight lines parallel with the scanning direction making it possible to calculate a scanning path for causing scanning to be made mainly along the direction of movement of the target. The treatment planning system can thereby realize dose distribution with improved uniformity. | 02-13-2014 |
| 20140058184 | USE OF NEURAL STEM CELLS FOR TREATMENT OF MALIGNANCY - An improved method for treatment of malignancies is based on the interaction between nerve cells and angiogenesis of malignancies. In general, the method comprises: (1) harvesting neural stem cells; (2) culturing neural stem cells under conditions such that the cells proliferate while retaining their ability to differentiate; (3) applying a biocompatible adhesive to a post-surgical site of a malignancy; and (4) following the application of the biocompatible adhesive to the post-surgical site of the malignancy, applying the cultured neural stem cells to the post-surgical site of the malignancy to remove residual tumor cells and to induce endothelial cell apoptosis. The method can further comprise the administration of a therapeutically effective quantity of at least one anti-neoplastic therapeutic agent or administration of a therapeutically effective quantity of anti-neoplastic ionizing radiation. The invention further encompasses kits for use in treating malignancies. | 02-27-2014 |
| 20140058185 | RADIATION THERAPY APPARATUS AND CONTROL METHOD - According to one embodiment, a radiation therapy apparatus includes a radiation irradiation device, a detector included in a PET scanner, a control unit, and a PET image reconstruction unit. The radiation irradiation device emits a therapeutic radiation. The detector counts light derived from gamma rays, and is provided with a gap portion through which the therapeutic radiation passes on a plane of rotation about the body axis of a subject. The control unit controls the radiation irradiation device and the detector so as to rotate in synchronization with each other in a state capable of emitting the therapeutic radiation to the gap portion. The PET image reconstruction unit reconstructs a PET image based on position information at the time of counting of the detector that nearly coincidentally counts pair annihilation gamma rays in a state where the control unit performs rotation control. | 02-27-2014 |
| 20140058186 | CHARGED-PARTICLE BEAM IRRADIATION DEVICE - A charged-particle beam irradiation device, which irradiates an irradiation target with a charged-particle beam, includes a transport line that transports the charged-particle beam and a rotating gantry that is rotatable about a rotation axis. The transport line includes an inclination portion making the charged-particle beam travel so that the charged-particle beam is inclined to be separated from the rotation axis, and is formed to turn the charged-particle beam in a rotation direction of the rotation axis and to bend the charged-particle beam, which has turned in the rotation direction, toward the rotation axis. The rotating gantry is formed of a cylindrical portion that receives the irradiation target and supports the transport line. The inclination portion is disposed in the cylindrical portion of the rotating gantry. The charged-particle beam irradiation device further includes blocking members that block radiation emitted from the transport line disposed in the cylindrical portion. | 02-27-2014 |
| 20140066687 | RADIATION THERAPY OF PROTRUDING AND/OR CONFORMABLE ORGANS - A system provided for delivering Accelerated Partial Breast Irradiation (APBI) and for delivering a boost to standard whole-breast irradiation (WBI) for the treatment of breast cancer that significantly reduces the risks of adverse cosmetic outcomes and toxicities. This is achieved by a method and device for delivering a uniform radiation dose to the target volume with significantly reduced dose to the non-target volume, skin and chest wall of the ipsilateral breast, and virtually no dose to the contralateral breast, lungs, and heart. | 03-06-2014 |
| 20140073831 | RADIATION TREATMENT PLANNING SYSTEM - Optimal irradiation conditions determined by iterative calculation are based upon an operator-defined irradiating direction, prescription dose, and other conditions. Dose matrixes A and B relating doses to calculation points from a beam delivered to irradiating positions are divided into a dose matrix A | 03-13-2014 |
| 20140073832 | ANTI-TUMOR T CELL IMMUNITY INDUCED BY HIGH DOSE RADIATION - Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual. | 03-13-2014 |
| 20140073833 | METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR DETERMINING PATIENT SPECIFIC TREATMENT PLANNING MARGINS - Methods, systems and computer-readable storage media relate to determining individualized treatment planning margins. The methods may include processing motion data of a target obtained from at least one marker for one or more periods. Each period may include a plurality of time intervals. The processing may include processing the motion data to determine an isocenter for each time interval along at least one of the axes of motion. The axes can include the x axis, the y axis, and/or the z axis. The method may include determining motion prediction data for each of the at least one of the axes; and determining treatment planning margins for each of the at least one of the axes based on the motion prediction data. The individualized treatment margins can be smaller and more optimal because the treatment margins can incorporate patient specific patterns of motion of a target (e.g., an organ). | 03-13-2014 |
| 20140073834 | SYSTEM AND METHOD FOR RADIATION BEAM MEASUREMENT NORMALIZATION - A radiotherapy system includes a radiotherapy device, such as a LINAC, operable to direct a radiation beam from a head thereof during operation, a field detector positioned to be within the radiation beam during operation of the radiotherapy device and operable to generate a beam measurement signal, a reference detector positioned to be outside of the radiation beam during operation of the radiotherapy device and operable to generate a reference signal, and at least one computer in signal communication with the field detector and the reference detector and configured with software to normalize the beam measurement signal based on the reference signal and to output a normalized beam measurement. | 03-13-2014 |
| 20140081068 | Radiation Detector and Radiotherapy Apparatus - The present invention provides a radiation detector which comprises a tube and detector elements distributed over the tube. Such an arrangement can be used to provide information on a radiation beam prior to interaction with a patient and after interaction with the patient. The detector is particularly compact and therefore suited to use with apparatus where space is restricted. By a particular arrangement of detectors and optical fibres, the detector can provide data at all angles of rotation. | 03-20-2014 |
| 20140088336 | PARTICLE BEAM THERAPY SYSTEM - An particle beam therapy system comprises a scanning electromagnet for scanning a particle beam which travels in a vacuum duct so as to irradiate an irradiation object and an irradiation unit comprising a beam outlet window, wherein the irradiation unit is configured such that the vacuum duct can be divided by a flange surface which is provided at a position closer to an irradiation object than a scanning electromagnet, in a case where a vacuum duct for a scanning irradiation method which is provided at a position closer to an irradiation object than the flange surface is moved so as not to overlap a beam line of the particle beam, a ride filter for a broad beam irradiation method can be provided at space where the vacuum duct for a scanning irradiation method was provided before it was moved. | 03-27-2014 |
| 20140094637 | FOCUSING A PARTICLE BEAM USING MAGNETIC FIELD FLUTTER - An example particle accelerator may include the following: a voltage source to sweep a radio frequency (RF) voltage in a cavity to accelerate particles from a plasma column, where the cavity has a magnetic field causing particles accelerated from the plasma column to move orbitally within the cavity, and where the magnetic field has flux that bows at edges of the cavity; a regenerator to provide a magnetic field bump within the cavity to thereby change successive orbits of the particles accelerated from the plasma column so that, eventually, particles output to an extraction point, where the regenerator is located at a radius in the cavity relative to the plasma column; and ferromagnetic arrangements located in the cavity proximate to the radius, where each ferromagnetic arrangement provides a magnetic field bump, and where ferromagnetic arrangements adjacent to the regenerator are separated from the regenerator by a space. | 04-03-2014 |
| 20140094638 | CONTROLLING INTENSITY OF A PARTICLE BEAM - In an example, a synchrocyclotron includes a particle source to provide pulses of ionized plasma to a cavity; a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column outwardly; and an extraction channel to receive a beam of particles from the cavity for output from the particle accelerator. The particle source is configured to control pulse widths of the ionized plasma in order to control an intensity of the beam of particles. This example synchrocyclotron may include one or more of the following features, either alone or in combination. | 04-03-2014 |
| 20140094639 | ADJUSTING ENERGY OF A PARTICLE BEAM - An example particle accelerator includes a coil to provide a magnetic field to a cavity; a particle source to provide a plasma column to the cavity; a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column, where the magnetic field causes particles accelerated from the plasma column to move orbitally within the cavity; an enclosure containing an extraction channel to receive the particles accelerated from the plasma column and to output the received particles from the cavity; and a structure arranged proximate to the extraction channel to change an energy level of the received particles. | 04-03-2014 |
| 20140094640 | Magnetic Field Regenerator - An example particle accelerator includes the following: a voltage source to provide a radio frequency (RF) voltage to a cavity to accelerate particles from a plasma column, where the cavity has a magnetic field causing particles accelerated from the plasma column to move orbitally within the cavity; an extraction channel to receive the particles accelerated from the plasma column and to output the received particles from the cavity; and a regenerator to provide a magnetic field bump within the cavity to thereby change successive orbits of the particles accelerated from the plasma column so that, eventually, particles output to the extraction channel. The magnetic field is at least 6 Tesla and the magnetic field bump is at most 2 Tesla. | 04-03-2014 |
| 20140094641 | Focusing a Particle Beam - An example particle accelerator includes the following: a resonant cavity in which particles are accelerated, where the resonant cavity has a background magnetic field having a first shape; and an extraction channel for receiving particles output from the resonant cavity. The extraction channel comprises a series of focusing regions to focus a beam of received particles. At least one of the focusing regions is a focusing element configured to alter a shape of the background magnetic field to a second shape that is substantially opposite to the first shape in the presence of a magnetic field gradient resulting from reduction of the background magnetic field from the resonant cavity to the extraction channel. | 04-03-2014 |
| 20140094642 | SKIN DOSE EVALUATION SUPPORT APPARATUS AND TREATMENT PLANNING APPARATUS - A skin dose evaluation support apparatus is provided with a skin region contour creation unit that creates skin region information including the boundary coordinates of a skin region, based on image data to be inputted when a treatment plan for a radiation therapy for a patient is created; and a display calculation unit that extracts a skin dose in a skin region, based on dose distribution data calculated by a dose distribution calculation unit of a treatment planning apparatus and the skin region information, and creates display data for displaying the extracted skin dose in a predetermined display format. | 04-03-2014 |
| 20140100407 | NAVIGATION DEVICE FOR BRACHYTHERAPY AND METHOD FOR OPERATING THE NAVIGATION DEVICE - A navigation device for brachytherapy is provided. The navigation device has a 3D imaging facility which can be moved relative to an operating table, and which is designed to obtain a 3D image dataset intraoperatively for a region of the body of a patient positioned on the operating table which is to be irradiated radioactively using at least one applicator. The navigation device has a control facility which is linked to the imaging facility and is designed to generate a volume model of the region of the body, in which volume model the at least one applicator is emulated in the position indicated by the position data, from the 3D image dataset and from position data for a spatial position of the at least one applicator. | 04-10-2014 |
| 20140100408 | Intensity Modulated Arc Therapy with Continuous Coach Rotation/Shift and Simultaneous Cone Beam Imaging - A system for radiotherapy includes a couch having a top lateral surface upon which a patient being treated by the system is positioned. The couch has continuous arc rotation for delivery of accelerated irradiation to the patient. The couch is movable rotationally and translationally. Delivery of the accelerated irradiation is performed during at least a portion of the movement. | 04-10-2014 |
| 20140107390 | IMPLEMENTATION AND EXPERIMENTAL RESULTS OF REAL-TIME 4D TUMOR TRACKING USING MULTI-LEAF COLLIMATOR (MLC), AND/OR MLC-CARRIAGE (MLC-BANK), AND/OR TREATMENT TABLE (COUCH) - Methods and systems of operating a support structure and beam shaping mechanism in a manner that compensates for motion patterns exhibited by a patient, promotes comfort of the patient, and optimizes accuracy of delivery of radiotherapy to a targeted location within the patient. The support structure can be a treatment table or couch and the beam shaping mechanism can be a multi-leaf collimator (MLC), and/or an MLC-bank/-carriage. The control system can utilize algorithms for predicting tumor motion and loading condition on the table/couch during radiation therapy. | 04-17-2014 |
| 20140107391 | USING HEAT SHOCK PROTEINS TO IMPROVE THE THERAPEUTIC BENEFIT OF A NON-VACCINE TREATMENT MODALITY - The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an α2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or α2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality. | 04-17-2014 |
| 20140107392 | Method of Dose Comparison for In Vivo Dosimetry - The invention relates to in vivo dosimetry techniques and can be used for comparison of dose measured in reference point and dose calculated at the same place with computerized treatment planning system. The suggested method takes into consideration dose difference and distance-to-agreement between measured and calculated points and uses a region of measurements (ROM) contoured as an organ at risk so that dose differences inside the ROM and acceptance interval are defined with the dose volume histogram of the ROM. The method can be used for evaluation of influence of ROM homogeneity and dosimeter movement on the difference between calculated and measured doses. | 04-17-2014 |
| 20140107393 | DEVICE FOR RESTRAINT OF PATIENTS ON A TABLE - The present invention is a device for the restraint of patients on a treatment table. More specifically, the invention is designed to provide lateral side pressure on a patient in the abdomen, thorax, and hip areas during a radiation treatment. The main components of the device are paddle(s) and at least one crossbar assembly. The paddles are coupled to a crossbar assembly, which is positioned on a treatment table under the body cushion in which the patient is positioned. The paddles can be moved laterally along the crossbar such that they put lateral pressure on the cushion and the patient. | 04-17-2014 |
| 20140107394 | SYSTEM AND METHODS FOR USING A DYNAMIC SCHEME FOR RADIOSURGERY - The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system. | 04-17-2014 |
| 20140107395 | HADRON TREATMENT PLANNING WITH ADEQUATE BIOLOGICAL WEIGHTING - Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region. | 04-17-2014 |
| 20140114113 | Proton Treatment Location Projection System - Treatment volume projection systems and methods for use in treating patients, including an image scanner to capture an image of a patient's treatment volume, a processor to process the image to generate a treatment volume image corresponding to at least a portion of the treatment volume, and an image projector to project the treatment volume image onto a projection surface. The treatment volume image can include an x-y scanning area of the treatment volume to assist delivery of treatment to the patient. | 04-24-2014 |
| 20140114114 | Systems and methods for the management and provision of radiotherapy - Methods and apparatus for the management and provision of radiotherapy are described in which values for dosimetric parameters are re-evaluated just prior to treatment, on the basis of the treatment plan as loaded into the radiotherapy apparatus, and during treatment, on the basis of monitored machine parameters. By displaying dosimetric parameters rather than complicated machine parameters, the technician operating the radiotherapy apparatus is able to monitor the dose provided to a patient undergoing therapy. Misadministration of radiation as a result of corrupted data or corrupted control signals are prevented. | 04-24-2014 |
| 20140121441 | Active Floor for Proton Therapy - An operator positioning apparatus for a proton treatment system includes: a proton beam nozzle to emit a proton beam to a targeted region of a patient; a gantry wheel having a front face to support the proton beam nozzle to direct the proton beam to an isocenter of the gantry wheel corresponding to a center of the targeted region, wherein the gantry wheel rotates the proton beam nozzle around the isocenter; an active floor that horizontally translates across the front face of the gantry wheel, the active floor having an opening having a width through which the proton beam nozzle protrudes when the proton beam nozzle is located below the targeted region. | 05-01-2014 |
| 20140121442 | Proton Treatment Gantry System - A gantry apparatus for a proton treatment system, including a proton beam nozzle to emit a proton beam to a targeted region of a patient, a gantry wheel to support the proton beam nozzle to direct the proton beam to an isocenter of the gantry wheel corresponding to a center of the targeted region, a plurality of adjustable bearings incrementally spaced apart along an outer diametrical surface of the gantry wheel, and a bearing surface to support a portion of the adjustable bearings such that when the wheel is rotated from a first angular position to a second angular position, at least a portion of the bearings contact the bearing surface to raise or lower the gantry wheel to realign the proton beam to the center of the targeted region. | 05-01-2014 |
| 20140128658 | ENRICHED 10-BORON COMPOSITION FOR CANCER THERAPY AND A METHOD OF SYNTHESIZING THE SAME - The embodiments herein provide a method of synthesizing a novel enriched 10-boron drug for treatment of cancer by Boron Neutron Capture Therapy (BNCT) method. In BNCT, drug containing enriched 10-Boron has the important role in final treatment efficiency. The composition is Enriched 10-Boron Calcium Fructo Borate (E | 05-08-2014 |
| 20140135561 | PROTON BEAM GENERATION APPARATUS AND TREATMENT METHOD USING THE APPARATUS - Provided is a proton beam generation apparatus. The apparatus includes a laser system providing a laser pulse, a phase shift plate polarizing the laser pulse to be spirally radial to be transduced to be a spirally radial shape polarized laser pulse, and a target for generating a proton beam, generating a proton beam due to the spirally radial shape polarized laser pulse. | 05-15-2014 |
| 20140135562 | TARGET FOR GENERATING POSITIVE IONS, METHOD OF FABRICATING THE SAME, AND TREATMENT APPARATUS USING THE TARGET - Provided is an ion beam treatment apparatus. The treatment apparatus includes a target for generating positive ions including a thin film for generating positive ions and nanowires disposed on at least one side of the thin film for generating positive ions, and a laser for emitting a laser beam incident on nanowires to project positive ions to a tumor region of a patient by generating the positive ions from the thin film for generating positive ions. Each of the nanowires may include a metal nanocore and a polymer shell surrounding the metal nanocore. The laser beam incident on the nanowires forms surface plasmon resonance, a near field having an intensity enhanced more than an intensity of the laser beam is formed by the surface plasmon resonance, and the positive ions are emitted from the thin film for generating positive ions by the near field. | 05-15-2014 |
| 20140135563 | PLURIDIRECTIONAL VERY HIGH ELECTRON ENERGY RADIATION THERAPY SYSTEMS AND PROCESSES - A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy. In addition to the unique physical advantages of extremely rapid radiation delivery, there may also be radiobiological advantages in terms of greater tumor or other target control efficacy for the same physical radiation dose. | 05-15-2014 |
| 20140155677 | Treatment of Anxiety Disorders by External Application of Ionizing Radiation - Medical systems, devices, and methods provide improved radiosurgical techniques for treatment of anxiety disorders (such as Post-Traumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD), Panic Disorder, Social Phobia, Specific Phobia, and the like). Radiation can be directed from a radiation source outside the patient toward a target tissue deep within the patient's brain using a stereotactic radiosurgical platform, typically without having to impose the surgical trauma associated with accessing deep brain tissues. The target will often include at least a portion of the amygdala, with exemplary treatments being directed to targets that are limited to a sub-region of the amygdala. Rather than applying sufficient radiation to kill the neural tissue within the target, a cellularly sub-lethal dose of the radiation may be applied. Without imposing frank cell death throughout the target, the radiation can mitigate the anxiety disorder, obesity, or the like, often by modulating the level of neural activity within the target and in associated tissues. | 06-05-2014 |
| 20140155678 | FOCUSED RADIATION FOR AUGMENTING IMMUNE-BASED THERAPIES AGAINST NEOPLASMS - An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers. | 06-05-2014 |
| 20140163300 | PATIENT ALIGNMENT SYSTEM WITH EXTERNAL MEASUREMENT AND OBJECT COORDINATION FOR RADIATION THERAPY SYSTEM - A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems. | 06-12-2014 |
| 20140163301 | Scanning Systems for Particle Cancer Therapy - A particle beam to treat malignant tissue is delivered to a patient by a gantry. The gantry includes a plurality of small magnets sequentially arranged along a beam tube to transfer the particle beam with strong focusing and a small dispersion function, whereby a beam size is very small, allowing for the small magnet size. Magnets arranged along the beam tube uses combined function magnets where the magnetic field is a combination of a bending dipole field with a focusing or defocusing quadrupole field. A triplet set of combined function magnets defines the beam size at the patient. A scanning system of magnets arranged along the beam tube after the bending system delivers the particle beam in a direction normal to the patient, to minimize healthy skin and tissue exposure to the particle beam. | 06-12-2014 |
| 20140163302 | METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR IMAGE-GUIDED TREATMENT PLANNING AND ASSESSMENT - Methods, systems and computer-readable storage media relate to image-guided treatment planning and treatment assessment. The methods, systems, and the computer-readable storage medias according to embodiments can analyze treatment response and can determine an accurate, outcome-based response assessment of treatment (e.g., radiation treatment). The methods may include a method for determining a treatment response. The method may include registering at least a first image data and a second image data of a subject, the first image data corresponding to a first time point, the second image data corresponding to a second time point, the first time point and the second time point being different with respect to a treatment session and/or treatment stage. The method may include processing the registered image to determine a treatment response. The registering may be based on deformable registration. | 06-12-2014 |
| 20140171725 | RADIATION SYSTEMS WITH MINIMAL OR NO SHIELDING REQUIREMENT ON BUILDING - A radiation system includes: a first support; a first structure rotatably coupled to the first support so that the first structure is rotatable about a first axis relative to the first support; a second structure rotatably coupled to the first structure so that the second structure is rotatable about a second axis that forms a non-zero angle relative to the first structure; and a first radiation source connected to the second structure; wherein the first structure and the second structure are parts of a capsule for accommodating at least a portion of a patient. | 06-19-2014 |
| 20140171726 | DOSE-OPTIMISED PATIENT POSITIONING FOR RADIOTHERAPY - The present invention relates to a method for positioning an arrangement of at least one beam position relative to a patient's body when the patient is placed for treatment by means of a treatment device which can emit treatment radiation, wherein the at least one beam position describes at least one position of at least one treatment beam, wherein the arrangement is referred to as the treatment arrangement and the treatment beam comprises the treatment radiation, wherein the method is executed by a computer and comprises the following steps:
| 06-19-2014 |
| 20140179978 | Neutron Source for Neutron Capture Therapy - A therapy apparatus for producing thermal neutrons at a tumor site in a patient has a plurality of fast neutron sources surrounding a moderator, a fast neutron reflecting media around the fast neutron sources, a gamma-ray and neutron shielding media surrounding the fast neutron reflecting media, and a patient chamber positioned inside the moderator. The fast neutron sources are positioned around the moderator to maximize and direct the neutron flux to said tumor site. | 06-26-2014 |
| 20140187843 | RADIOISOTOPE-PHOTODYNAMIC THERAPY FOR CANCER TREATMENT - The present invention provides compositions and methods for radioisotope-photodynamic therapy for treating cancer. Specifically, the invention relates to compositions and methods for administering a radiation emitter, a rare-earth doped down-converting nanophosphor and a photosensitizer for treating cancer. | 07-03-2014 |
| 20140187844 | PARTICLE BEAM THERAPY SYSTEM - A particle beam therapy system is disclosed which includes: a synchrotron accelerating a charged particle beam injected from a pre-accelerator up to a predetermined energy level before applying a high-frequency voltage to an extraction device to extract the charged particle beam caused to exceed a stability limit; a beam transportation system transporting the charged particle beam extracted from the synchrotron up to a treatment room, and an irradiation device irradiating a patient in the treatment room with the charged particle beam in conformity to the patient's tumor shape. The synchrotron has functionality to accelerate or decelerate the charged particle beam successively to extract the charged particle beam at a plurality of energy levels during an extraction phase of the synchrotron, the beam transportation system further having functionality to block off an unnecessary charged particle beam extracted from the synchrotron during acceleration or deceleration. | 07-03-2014 |
| 20140187845 | RADIO-IMMUNO-MODULATION TREATMENT FOR ADVANCED CANCER AND MONITORING TOLERANCE AND CELLULAR IMMUNE RESPONSE AT THE TUMOR SITE - A combination therapy for treating advanced cancer, comprises, first, performing targeted low dose radiation therapy on a recipient tumoral site to generate an inflammation zone and an immuno-stimulant effect, including release of cytokines and chemokines. Secondly, hematopoietic cells from a suitable donor are administered intravenously in order to initiate an allogeneic reaction. These cells could be collected either as PBMC from an adult donor, or from an UCB donation. The post-radiotherapy inflammation zone will attract the newly injected donor cells to the tumor bed, triggering an immunological cancer cell rejection. The cellular response in the recipient is monitored and post-treatment evaluation for recipients' side effects is also provided. | 07-03-2014 |
| 20140187846 | METHODS AND APPARATUS FOR THE PLANNING AND DELIVERY OF RADIATION TREATMENTS - Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity. | 07-03-2014 |
| 20140187847 | PARTICLE BEAM THERAPY SYSTEM - A particle beam therapy system comprising a treatment table, a treatment table control unit and an irradiation control unit configured to output an instruction for controlling the treatment table control unit, an accelerator and a scanning electromagnet, wherein after the treatment table control unit controls the treatment table so as for a patient isocenter which is reference position of an affected area of a patient to move to a position of an irradiation isocenter which is set at a position which is closer to an irradiation nozzle than an equipment isocenter which is reference of positional relation of the irradiation nozzle and the treatment table, the irradiation control unit outputs an instruction for irradiating the patient with a particle beam. | 07-03-2014 |
| 20140194667 | Method for Three Dimensional (3D) Lattice Radiotherapy - A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed. | 07-10-2014 |
| 20140206923 | RADIATION TREATMENT PLANNING SYSTEM AND METHOD OF RADIATION TREATMENT PLANNING - There is disclosed a radiation treatment planning system for preparing treatment planning information for carrying out radiation treatment. The apparatus includes an input unit with which an operator inputs a prescription dose and an irradiation angle; an arithmetic unit which prepares the treatment planning information by determining irradiation conditions in such a manner as to bring a dose distribution calculated based on the result of the input from the input unit closer to the prescription dose, and a display unit which displays the treatment planning information. The arithmetic unit sets, per point for radiation irradiation, an index representing the degree of demand for irradiation amount suppression, the degree of demand determined by the radiation irradiation point, and the arithmetic unit further determines the irradiation conditions using the index. | 07-24-2014 |
| 20140206924 | THERMOPLASTIC SHEET, A RADIATION MASK OF THERMOPLASTIC SHEET AND METHOD FOR PROVIDING SAID SHEET AND SAID MASK - The present invention relates to a thermoplastic composition suitable for manufacturing a thermoplastic sheet for producing a medical cast, such as a radiation mask. The composition has a polymeric component comprising a mixture of a styrene acrylonitrile copolymer and polycaprolactone, optionally together with a cross-linker and/or a filler, wherein the polymeric component comprises, 20 to 40 weight % of a styrene acrylonitrile copolymer and 80 to 60 weight % of a polycaprolactone, expressed in weight % of the polymeric component, wherein the thermoplastic composition has a glass transition temperature of 35° C.-80° C. The invention further relates to a thermoplastic sheet and to a medical cast, in particular a radiation mask, obtainable from said composition. In a final aspect, the invention relates to a method for producing said sheet and said radiation mask. | 07-24-2014 |
| 20140213841 | Non-Invasive In-Situ Radiation Dosimetry - A system for measuring radiation dose comprises an excitation device adapted for directing an energy wave at a volume of a substance comprising gas-filled microparticles, a detector for detecting a response signal emitted and/or modified from the volume of the substance comprising gas-filled microparticles; and a control unit. The control unit is adapted for calculating a dose of ionizing radiation previously received by the volume of the substance based on the response signal. A method includes measuring a received dose of ionizing radiation and using a contrast agent for non-invasive in-situ dosimetry. | 07-31-2014 |
| 20140221724 | REAL-TIME IN VIVO RADIATION DOSIMETRY USING SCINTILLATION DETECTOR - Apparatus and methods for measuring radiation levels in vivo in real time. Apparatus and methods include a scintillating material coupled to a retention member. | 08-07-2014 |
| 20140235918 | LASER ION SOURCE AND HEAVY PARTICLE BEAM THERAPY EQUIPMENT - One embodiment of a particle accelerator includes: a vacuum container with its inside evacuated to produce vacuum, the vacuum container being formed with a laser beam entrance window for allowing a laser beam to enter; a target arranged in the vacuum container so as to be irradiated with a laser beam to generate ions; and a condenser lens for focusing the laser beam onto the target. The condenser lens is arranged at the laser beam entrance window of the vacuum container, and takes a role of a vacuum bulkhead. | 08-21-2014 |
| 20140235919 | MULTI-LEAF COLLIMATOR, PARTICLE BEAM THERAPY SYSTEM, AND TREATMENT PLANNING APPARATUS - There are provided a leaf row in which a plurality of leaf plates are arranged in the thickness direction of the row in such a way that the respective one end faces of the leaf plates are trued up and a leaf plate drive mechanism that drives each of the plurality of leaf plates in such a way that the one end face approaches or departs from a beam axis. In each of the leaf plates, a facing side facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane including a first axis on the beam axis; the leaf plate drive mechanism drives the leaf plate along a circumferential orbit around the second axis, on the beam axis, that is perpendicular to the beam axis and the first axis. | 08-21-2014 |
| 20140235920 | Radiosurgical Neuromodulation Devices, Systems, and Methods for Treatment of Behavioral Disorders by External Application of Ionizing Radiation - Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased. | 08-21-2014 |
| 20140235921 | SYSTEM AND METHOD FOR POSITIONING WITH NUCLEAR IMAGING - The invention relates to a system for determining the position of radioactively marked target tissue of a patient in radiation therapy by means of a radiation therapy device. The system comprises at least one detector for the imaging detection of the radiation distribution of a radioactive radiation source that is located in target tissue region, a computing unit that is designed to calculate the pose of the target tissue region from measurement data of the detector and to calculate a correction variable as the difference between the calculated pose and comparison values, and an interface by means of which the data for the calculated pose of radioactively marked target tissue region and the correction variable can be transmitted by the computing unit to a radiation therapy device or a patient positioning device. The invention further relates to a corresponding method. | 08-21-2014 |
| 20140235922 | PARTICLE BEAM TREATMENT SYSTEM AND BEAM POSITION CORRECTING METHOD THEREOF - A particle beam treatment system includes an accelerator system that accelerates a charged particle beam and a beam transport system that transports a high-energy beam emitted from the accelerator to an irradiation location, wherein the beam transport system is provided with at least one steering electromagnet and at least one beam position monitor corresponding to the at least one steering electromagnet, and wherein the at least one beam position monitor supplies an excitation current for correcting a beam position, which periodically varies, to the at least one steering electromagnet. | 08-21-2014 |
| 20140235923 | DOSE COMPUTATION FOR RADIATION THERAPY USING HETEROGENEITY COMPENSATED SUPERPOSITION - A system for radiation therapy includes a radiation planning system. The radiation planning system includes a data processor that is adapted to receive information concerning an intended radiation treatment region of a body, receive a calculated initial energy released per unit mass for a plurality of locations within the body, compute a radiation dose at a plurality of locations within the radiation treatment region based on the calculated initial energy released per unit mass and including radiation dose contributions due to scattering from other locations within the body, and determine radiation therapy parameters for providing radiation treatment to the intended radiation treatment region based on the radiation dose computed at the plurality of locations within the radiation treatment region. Including radiation dose contributions due to scattering from other locations within the body take into account density discontinuities in the body. | 08-21-2014 |
| 20140243576 | PARTICLE ACCELERATOR AND MEDICAL EQUIPMENT - One embodiment of a particle accelerator includes: a particle source from which a particle beam is extracted with a beam pulse width of not greater than 2 μsec; a linear accelerator for accelerating the particle beam extracted from the particle source; a synchrotron for receiving the particle beam transported thereto from the linear accelerator and causing the particle beam to circulate in order to accelerate it until it gets to a predetermined energy level; a bump electromagnet for shifting the circulating path of the particle beam each time it makes a full turn; and a control unit for controlling the extent of magnetic excitation of the bump electromagnet and for controlling the timing of magnetic excitation of the bump electromagnet according to the pulse timing of the particle source. | 08-28-2014 |
| 20140243577 | Combined Organ and Hematopoietic Cells For Transplantation Tolerance of HLA Mismatched Grafts - Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance. | 08-28-2014 |
| 20140243578 | RADIOWAVE TREATMENT FOR CANCER - A method of treating cancer in an adult subject comprising an electromagnetic (EM) radiation treatment step of administering to the subject an effective dose of EM radiation of a frequency in the range of 430-440 MHz (UHF) within a period of ≦45 minutes, the EM radiation being provided by a UHF emitter defining an exposure region, wherein for the duration of the period the subject is reclined upon a horizontal or substantially horizontal surface, and wherein the surface and UHF emitter are arranged for relative movement such that the exposure region passes, continually or periodically, between a first position and at least a second position on the subject. The method may further comprise an auxiliary treatment step such as X-ray therapy or treatment with certain chemical agents such as oxidised glutathione (GSSG) and/or a precursor thereof (eg glutathione (GSH)) in combination with a non-toxic oxidising agent, and S-methyl-L-cysteine sulphoxide (SMCO) | 08-28-2014 |
| 20140243579 | DUAL-ENERGY IMAGE SUPPRESSION METHOD - An imaging process capable of selectively enhancing visualization of soft tissues, for example, a tumor. The imaging process includes producing a hard tissue-enhanced image of a body containing both soft and hard tissues, wherein the hard tissue-enhanced image contains images of the hard tissues that are enhanced relative to the soft tissues. A radiographic image of the body and the soft and hard tissues thereof are then obtained, after which a weighted subtraction algorithm is performed between the radiographic image and the hard tissue-enhanced image to produce a soft tissue-enhanced image in which imaging of the soft tissues is enhanced relative to the hard tissues. The hard tissue-enhanced image may be produced by obtaining first and second initial radiographic images of the body including the soft and hard tissues, and then performing a weighted subtraction algorithm on the first and second initial radiographic images to produce the hard tissue-enhanced image. | 08-28-2014 |
| 20140243580 | ENDORECTAL BALLOON WITH GAS RELEASE LUMEN - A rectal balloon apparatus comprises a shaft having a fluid passageway extending therethrough. A rectal gas relieving lumen may be positioned with a central shaft for removal of rectal gas. The gas releasing lumen can also or in the alternative be provided along an outer surface of the balloon. A motion detecting sensor and a radiation detecting sensor may be positioned with the balloon, the shaft, and/or the rectal gas release lumen. | 08-28-2014 |
| 20140243581 | METHODS OF TREATING DNA DAMAGE - The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide. | 08-28-2014 |
| 20140243582 | Inclined Beamline Motion Mechanism - A radiotherapy particle emitter positioning device is provided. The positioning device includes first and second arcuate support frames, a mounting carriage and a drive arrangement. The first and second arcuate support frames each include a drive track arrangement defining an arcuate carriage guide path. The mounting carriage is configured for supporting the radiotherapy particle emitter. The mounting carriage is mounted to and supported by the support frames. The mounting carriage is connectable to the drive track arrangements and moveable along the carriage guide path. The mounting carriage also includes the drive arrangement. The drive arrangement engages the drive track arrangements for driving the mounting carriage along the drive track arrangements and the carriage guide path. | 08-28-2014 |
| 20140249347 | USE OF PYRIDONE DERIVATIVES IN THE PREVENTION OR TREATMENT OF TISSUE OR ORGAN TOXICITY INDUCED BY CYTOTOXIC AGENTS AND RADIATION - The present invention is directed to a novel use of pyridone derivatives such as pirfenidone for the prevention and treatment of damages to tissues or organs induced by various cytotoxic agents, such as chemotherapeutic agents, biologics, immunosuppressants and radiation. Such prophylactic and/or therapeutic effects of the pyridone derivatives make it possible to increase therapeutic dosages of the cytotoxic agent, thereby enhancing the therapeutic efficacy of the cytotoxic agent and radiation therapy. | 09-04-2014 |
| 20140249348 | METHOD AND APPARATUS FOR EMISSION GUIDED RADIATION THERAPY - An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path. | 09-04-2014 |
| 20140257011 | TREATMENT DELIVERY CONTROL SYSTEM AND METHOD OF OPERATION THEREOF - The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements. | 09-11-2014 |
| 20140257012 | Planning a Treatment Beam Aimed at One or More Target Regions - A method and an apparatus for planning a treatment beam aimed at at least one target region are provided. Planning parameters having associated predetermined parameter values are for performing a treatment that is to be applied with the treatment beam. The method includes defining a first predetermined parameter value of the planning parameters that is suitable for the irradiation of a treatment region that includes at least one target region. The method also includes ascertaining, based on the first predetermined parameter value, a first probability distribution in relation to an optimizable variable that is prespecified based on deviations to be expected when carrying out the irradiation. | 09-11-2014 |
| 20140275695 | Skin HDR Brachytherapy Multichannel Applicators and Methods of Brachytherapy Treatment - Applicators for HDR brachytherapy for topical skin treatment which employ multiple channels for radioisotope sources, oriented by the applicator generally parallel to each other and to a desired treatment area skin surface. These applicators provide good radiation exposure uniformity. Filtration of undesirable low energy radiation may be employed using an attached filter element. The applicators are particularly adapted for the treatment of squamous and basal cell skin cancers or other skin lesions. The applicators may provide two or more source guides in various sizes and shapes are described. | 09-18-2014 |
| 20140275696 | Systems And Methods For Isotopic Source External Beam Radiotherapy - The subject matter described herein provides methods for developing an IMRT treatment plan for a radiotherapy system. In one aspect, the method can include providing initial treatment parameters. These parameters can include a number of isotopic beams, a transmission angle for each beam, a prescribed dose for a target, and dose volume histogram constraints. The method can further include determining an initial fluence map including one or more beamlets. The initial fluence map can specify a fluence value for each beamlet. The method can further include determining a delivery sequence for the fluence values in the initial fluence map. The delivery sequence can include one or more apertures formed by the leaves of a collimator. These apertures can have a specified size constrained to substantially less than a maximum size associated with the collimator, when the isotopic beam is near a critical structure. Related apparatus and systems are also described. | 09-18-2014 |
| 20140275697 | TREATMENT COUCH FOR SMALL ISOCENTRIC ROTATIONS - A treatment system for a patient includes a treatment couch to position the patient. The treatment couch includes a couch top and one or more stages to pitch the couch top about a lateral axis and/or roll the couch top about a longitudinal axis, translate the couch top along lateral directions and/or longitudinal directions, rotate the couch top about a vertical axis, and translate the couch top along vertical directions. | 09-18-2014 |
| 20140275698 | INTRA-FRACTION MOTION MANAGEMENT SYSTEM AND METHOD - The present invention relates to the field of radiation therapy. In particular, the invention concerns systems and methods for monitoring intra-fraction motions of patients in connection with treatment cancer in radiation therapy system. A patient marker is attached on the nose of the patient and images of the patient marker and reference markers of a reference tool is captured at predetermined time intervals, wherein the reference tool comprises reference markers and is arranged in a defined position relative to a patient fixation arrangement for fixation of the patient during treatment. A position of the patient marker relative the reference tool is determined based on images captured by an optical tracking system, wherein changes in the position provide information if the patient or a part of the patient has moved. | 09-18-2014 |
| 20140275699 | COMPACT PROTON THERAPY SYSTEM WITH ENERGY SELECTION ONBOARD A ROTATABLE GANTRY - Systems and apparatuses for providing particle beams for radiation therapy with a compact design and suitable to a single treatment room. The radiation system comprises a stationary cyclotron coupled to a rotating gantry assembly through a beam line assembly. The system is equipped with a single set of dipole magnets that are installed on the rotating gantry assembly and undertakes the dual functions of beam energy selection and beam deflection. The energy degrader may be exposed to the air pressure. The beam line assembly comprises a rotating segment and a stationary segment that are separated from each other through an intermediate segment that is exposed to an ambient pressure. | 09-18-2014 |
| 20140275700 | Method and Apparatus for Using Patient-Experience Outcomes When Developing Radiation-Therapy Treatment Plans - A control circuit has access to information that correlates a plurality of patient-experience outcomes with corresponding delivered-radiation metrics and uses that plurality of patient-experience outcomes in conjunction with developing a radiation-therapy treatment plan for a particular patient. Those patient-experience outcomes can comprise, for example, information regarding how various patients fared post-radiation treatment as regards such things as post-radiation treatment life expectancy, tumor eradication success, and one or more other quality-of-life metrics. These teachings will accommodate using a particular one of the patient-experience outcomes as an optimization goal when optimizing candidate radiation-therapy treatment plans to develop the radiation-therapy treatment plan. In such a case these teachings will further accommodate, if desired, permitting a user to modify one or more optimization objectives while displaying intermediate optimization results. | 09-18-2014 |
| 20140275701 | Method and Apparatus for Using Preferred Angles When Irradiating Patient Target Volumes - A control circuit identifies (prior to optimizing a radiation-treatment plan) at least one angle (such as one or more gantry angles as correspond to an arc-therapy treatment platform) to provide one or more identified angles. The control circuit then optimizes a radiation-treatment plan with respect to a particular patient target volume by using the identified angle(s) as preferred angles as regards irradiating the patient target volume. Being “preferred,” the radiation-treatment plan is thereby influenced (without being required) towards changing a rate of moving the gantry when traversing the preferred angle(s). For example, the plan can be biased towards slowing down movement of the gantry at such angles to thereby deliver a relatively greater amount of radiation to the patient target volume at the preferred angle. | 09-18-2014 |
| 20140275702 | Method and Apparatus for Using a Designated Patient Structure as an Area to be Masked From Radiation - A control circuit provides a user with an opportunity to designate one or more patient structures for a particular patient that are to be protected from radiation. When optimizing a radiation-treatment plan for that patient, then, the control circuit uses the designated patient structure(s) as an area to be masked from radiation during administration of the radiation-treatment plan. By one approach the aforementioned opportunity to designate patient structures as being designated patient structures comprises providing the user with an opportunity to so designate patient structures via a display. The aforementioned masking can be accomplished as desired including by appropriate use of a multi-leaf collimator. | 09-18-2014 |
| 20140275703 | METHOD AND SYSTEM FOR DOSE DETERMINATION OF RADIATION THERAPY - Methods for performing dose determination and cost function gradients in a radiation therapy are disclosed, which include: discretizing a volume-of-interest (VOI) into a set of voxels; identifying a set of beamlets which deposit dose contributions of radiation to the VOI, and each beamlet has a weight factor; transforming the dose contributions into a first domain, and transforming the weight factors into a second domain orthogonal to the first domain; calculate the local derivatives of a cost function of dose and cost function gradients with respect to the weights of the beamlets. | 09-18-2014 |
| 20140275704 | METHODS AND SYSTEM FOR BREATHING-SYNCHRONIZED, TARGET-TRACKING RADIATION THERAPY - Preparing a plan to synchronize radiation delivery to a target in a patient with patient breathing phase and amplitude as the independent variable comprising (a) obtaining simultaneous data on patient breathing and target shape and location, (b) correlating the data and optimizing the correlation, (c) establishing optimal parameters of radiation delivery for each breathing phase/amplitude or for each target shape/location; and (d) synchronizing radiation delivery to a target in a patient with patient breathing comprising (a) positioning the patient, (b) monitoring actual breathing or the shape/location of the target, and (c) while monitoring, delivering radiation to the target according to a plan; and a system for controlling radiation delivery by a device to a target in a patient comprising (i) a processor, which receives and processes data on breathing or the shape/location of the target, and (ii) a controller, which controls radiation delivery to the target according to a plan, which synchronizes radiation delivery to the target with breathing data or the shape/location of the target. | 09-18-2014 |
| 20140275705 | PROSPECTIVE EVALUATION OF TUMOR VISIBILITY FOR IGRT USING TEMPLATES GENERATED FROM PLANNING CT AND CONTOURS - The plan CT is described to generate dual energy (DRR) that stimulates the treatment time radiographs in order to prospectively evaluate the angles in which issues for the template matching algorithm are present, and thus the visibility of the tumor. The present invention uses template matching to quantify the “trackability” of the target from different angles or directions. The peak-to-side lobe ratio is used to measure trackability. The results of this process influence treatment planning. For example, based on the outcome, either less or no dose is planned for the angles in which the location of the templates cannot be verified and thus, the tumor. | 09-18-2014 |
| 20140275706 | SYSTEMS AND METHODS FOR DETERMINING AND DELIVERING RADIATION TREATMENT PLANS - A computer-implemented method for generating and/or delivering a radiation treatment plan is provided. The method comprises reading a modular radiation dose kernel that defines a three dimensional radiation isocenter dose formed from a sum of a plurality of radiation beams, reading serial slice data that define three dimensional closed surfaces representing a lesion, critical structure, or organ and generating a radiation treatment plan based on the radiation kernel file and the data that defines the three dimensional closed surface. The treatment plan can be translated for use by virtually any automated radiation delivery device. | 09-18-2014 |
| 20140275707 | INTRA-FRACTION MOTION MANAGEMENT SYSTEM AND METHOD - The present invention relates to the field of radiation therapy. In particular, the invention concerns systems and methods for monitoring intra-fraction motions of patients in connection with treatment cancer in radiation therapy system. A patient marker is attached on the nose of the patient and images of the patient marker and reference markers is captured at predetermined time intervals. The reference markers are arranged in defined positions relative to a patient fixation arrangement for fixation of the patient during treatment. A position of the patient marker relative the reference markers is determined based on images captured by an optical tracking system, wherein changes in the position provide information if the patient or a part of the patient has moved. | 09-18-2014 |
| 20140275708 | OPTIONALLY TRANSPORTABLE MACHINE FOR USE IN INTRAOPERATIVE ELECTRON RADIATION THERAPY - An electron therapy unit for delivering therapeutic electrons to a patient during an operation that is made up of a movable and stowable beam head that may be connected permanently or temporarily to either a base cabinet or a fixed structure using one or more optionally pivotable arms is provided. In an exemplary embodiment, the inventive electron therapy unit is a mobile unit suitable for in-hospital use or for shared use between hospitals or clinics. The unit is self-contained, small, light and easy to use. It has a very reliable, compact design, allowing for easy stowing to a small rugged configuration for transport. In another exemplary embodiment, the inventive electron therapy unit is a stationary unit. An ion chamber for use with such an optionally transportable electron therapy unit is also provided. The ion chamber employs two or more collector plates and associated bias plates, each having a centrally located hole that extends through the plate. Further provided is a method for reducing or eliminating the possibility of significantly higher current caused by electrical arcs and power excursions during operation of the inventive electron therapy unit. | 09-18-2014 |
| 20140275709 | METHODS AND SYSTEMS FOR DETERMINING THE DISTRIBUTION OF RADIATION DOSE AND RESPONSE - A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs. | 09-18-2014 |
| 20140275710 | RADIATION THERAPY TREATMENT PLAN IMPROVEMENT THROUGH USE OF KNOWLEDGE BASE - A method for determining a radiation therapy dose distribution starts with selecting and downloading a treatment type from a database. Then an organ at risk (OAR) distance to target map is determined, wherein the OAR distance to target map comprises distances to a target organ for respective portions of at least one OAR, and wherein the OAR distances are determined from at least one segmented patient organ image. Now a cohort average dose distance to target histogram is selected and downloaded from the database. After which, a dose value to the portions of the at least one OAR are assigned to form a first 3D dose distribution map, wherein the dose values are from the selected cohort average dose distance to target histogram. Now a second 3D dose distribution map is determined based on a field arrangement determined by the treatment type, and the first 3D dose distribution map. Finally, a dose distance to target histogram is calculated for the patient using the second 3D dose distribution map and the distance to target map. | 09-18-2014 |
| 20140275711 | 1-(Arylmethyl)-5,6,7,8-tetrahydroquinazolline-2,4-diones and Analogs and the Use Thereof - Disclosed are novel 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs thereof, represented by the Formula I, wherein Ar, A, B, R | 09-18-2014 |
| 20140288347 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 09-25-2014 |
| 20140288348 | RADIOTHERAPY TREATMENT DEVICE COMPRISING IMAGE ACQUISITION DEVICE AND IRRADIATION DEVICE, AND RADIOTHERAPY METHOD - A radiotherapy treatment device comprising an image acquisition device, in particular a magnetic resonance device, an irradiation device comprising in particular a linear accelerator, and a patient positioning device having a patient positioning platform, wherein a movement device is provided for jointly moving the image acquisition device and the irradiation device between an irradiation position, in which a radiotherapeutic treatment of a patient located on the patient positioning platform is possible by means of the irradiation device, and an image acquisition position, in which an image acquisition of the patient located on the patient positioning platform is possible by means of the image acquisition device is provided. A radiotherapy method for treating an irradiation target in a patient by means of such a radiotherapy treatment device is also disclosed. | 09-25-2014 |
| 20140288349 | THERAPEUTIC DEVICE FOR TREATING A PREDEFINED BODY PART OF A PATIENT WITH RAYS - A therapeutic device ( | 09-25-2014 |
| 20140296609 | Layer Structure for Epidermal Radionuclide Therapy - Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for β and γ radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (BCC) and the squamous cell carcinoma (SCC). With the aid of the layer structure, geometrically complex skin lesions caused by a tumor, as occurring e.g. on the outer edge of the auricle, may be treated easily. | 10-02-2014 |
| 20140296610 | PARTICLE BEAM IRRADIATION SYSTEM AND METHOD FOR OPERATING THE SAME - Operation control data of each of the constituent sub-units of a synchrotron is constructed by a combination of module data items (initial acceleration data item, plural energy change data items, and a deceleration control data item), corresponding to plural control intervals, respectively. A control start value, a control completion value, and a computing function for connecting the control start value with the control completion value are expressed in each of module data items. Further, the plural module data items are corrected on the basis of a correction data item of a residual field, and a power-supply control command value is sequentially outputted. By preparing correction table data of the residual field, expressed by irradiation energy and irradiation stage numbers of the irradiation energy beforehand, the correction table data items of the plural module data items are selected from the correction table data to be prepared. | 10-02-2014 |
| 20140309476 | CT ATLAS OF MUSCULOSKELETAL ANATOMY TO GUIDE TREATMENT OF SARCOMA - The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of musculoskeletal structure. The atlas contains a data set representing a 3D model of musculoskeletal structure divided into the relevant musculoskeletal anatomic terminology. The method further includes obtaining patient data. The patient data is in a patient coordinate set that corresponds to obtained atlas data in the atlas coordinate set. The atlas data is then morphed by performing a rigid registration between the at least one landmark identified in the patient coordinate set and the corresponding obtained atlas data in the atlas coordinate set and by performing a non-rigid registration of the musculoskeletal structure divided into the relevant contoured fascial compartments, skeletal structures and vascular structures while maintaining the rigid registration of the at least one landmark. The image of the patient coordinate set with the morphed atlas data is then displayed. | 10-16-2014 |
| 20140309477 | CT ATLAS OF THE BRISBANE 2000 SYSTEM OF LIVER ANATOMY FOR RADIATION ONCOLOGISTS - The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of hepatic anatomical information including three orders of division and obtaining patient data in a patient coordinate set. The method further includes morphing atlas data from the atlas coordinate set to the patient coordinate set by performing a rigid registration between the at least one landmark identified in the patient coordinate set and the corresponding obtained atlas data in the atlas coordinate set and by performing a non-rigid registration of the three orders of division of the hepatic structure while maintaining the rigid registration of the at least one landmark. | 10-16-2014 |
| 20140316183 | METHOD AND DEVICE FOR REGISTRATION AND IMMOBILIZATION - Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses. | 10-23-2014 |
| 20140316184 | TREATMENT PLANNING SYSTEM, DEVICE FOR CALCULATING A SCANNING PATH AND PARTICLE THERAPY SYSTEM - In a particle therapy treatment planning system for creating treatment plan data, the movement of a target (patient's affected area) is extracted from plural tomography images of the target, and the direction of scanning is determined by projecting the extracted movement on a scanning plane scanned by scanning magnets. Irradiation positions are arranged on straight lines parallel with the scanning direction making it possible to calculate a scanning path for causing scanning to be made mainly along the direction of movement of the target. The treatment planning system can thereby realize dose distribution with improved uniformity. | 10-23-2014 |
| 20140316185 | TUMOR TREATMENT WITH FREE RADICAL LIFETIMES ENHANCED BY PERSISTANT LOW STRENGTH MAGNETIC FIELD - In the treatment of a tumor ( | 10-23-2014 |
| 20140323793 | PARTICLE BEAM THERAPY DEVICE AND PARTICLE BEAM THERAPY DEVICE OPERATION METHOD - A control unit is provided with, a retaining section that retains a plurality of operation patterns each being a pattern of operation to be periodically repeated by an accelerator, the operation patterns having respective operation conditions adjusted for different emission times of an particle beam, to cause a deflection electromagnet in the accelerator to have an intended magnetic field intensity even under a presence of a hysteresis; a reading section for a plurality of slices of an irradiation target in a depth direction, which reads an irradiation condition for each of the slices; a selection section that selects the operation pattern suitable for each of the slices, on the basis of the read irradiation condition; and a main control section that controls, for each of the slices, the accelerator on the basis of the selected operation pattern and an irradiation device on the basis of the irradiation condition. | 10-30-2014 |
| 20140330063 | CHARGED PARTICLE CANCER THERAPY DOSE DISTRIBUTION METHOD AND APPARATUS - The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus. | 11-06-2014 |
| 20140330064 | Station parameter optimized radiation therapy (SPORT): a novel scheme for treatment planning and delivery in radiation therapy - A method of radiation therapy planning and delivery is provided that includes introducing a demand metric, using a volumetric modulation arc therapy system, to select a spatially optimized and non-uniform set of station or control points to be used for intensity modulation, where the set of station or control points are uniform or non-uniform, and selecting a set of control points at different gantry angles, using the volumetric modulated arc therapy system, and using the demand metric to prioritize which station or control point receives intensity modulation, where the volumetric modulated arc therapy system is differentially boosted at selected angles by inserting additional segments to the station, where the inserted additional apertures dosimetrically boost desired regions in a planning target volume to improve planning target volume coverage in a single arc rotation while sparing sensitive structures. | 11-06-2014 |
| 20140330065 | METHOD AND DEVICE FOR RADIATION THERAPY TREATMENT OF MULTIPLE TARGETS - The present invention is directed to a data processing method for determining a treatment plan for radiation therapy treatment of at least two spatially separate targets by means of a treatment device constituted to treat the at least two targets by means of one or more sub-beams during a treatment time, the one or more sub-beams constituting at least one treatment beam which is to pass through the at least two targets in accordance with a treatment plan during the treatment time, the treatment device being further constituted to allow for simultaneous treatment of the at least two targets by at least two of the sub-beams at least during a time interval during the treatment time, the method comprising the following steps performed by a computer:
| 11-06-2014 |
| 20140330066 | SYSTEM FOR IRRADIATING CHARGED PARTICLES AND METHOD FOR IRRADIATING CHARGED PARTICLES - A charged particle irradiation system is capable of shortening the irradiation time and the treatment time by performing efficient irradiation even when irregular variation occurs in the irradiation object during the gating irradiation. The extraction of the beam is stopped upon reception of a regular extraction permission end signal which is outputted based on a regular movement signal. An extractable state maintaining function operates upon the reception of the extraction permission end signal. When a preset standby time elapses without receiving an extraction permission start signal again during the standby time, the extractable state maintaining function finishes its operation and a charged particle beam generator decelerates the beam. Also, the extraction of the beam is stopped due to reception of an irregular extraction permission end signal during the irradiation. When the extraction permission start signal is received again during the standby time, the extraction of the beam is restarted. | 11-06-2014 |
| 20140336438 | BEAM SEGMENT-LEVEL DOSE COMPUTATION AND TEMPORAL MOTION TRACKING FOR ADAPTIVE TREATMENT PLANNING - A treatment planning system for generating patient-specific treatment. The system including one or more processors programmed to receive a radiation treatment plan (RTP) for irradiating a target over the course of one or more treatment fractions, said RTP including a planned dose distribution to be delivered to the target, receive motion data for at least one of the treatment fractions of the RTP, receive temporal delivery metric data for at least one of the treatment fractions of the RTP, calculate a motion-compensated dose distribution for the target using the motion data and the temporal delivery metric data to adjust the planned dose distribution based on the received motion data and temporal delivery metric data, and compare the motion-compensated dose distribution to the planned dose distribution. | 11-13-2014 |
| 20140336439 | PORTABLE PHANTOM DEVICE - A portable phantom device according to the present invention is a phantom device which is detachably installed in a bird cage that is coupled to an irradiator, and includes a body provided with an accommodation space having a cylindrical shape and a top of which is open so as to accommodate water, a horizontality adjustment maintaining portion which is detachably coupled to a side wall of the body; and a sensor holding portion which is installed on the side wall of the body so as not to interfere with the horizontality adjustment maintaining portion, so that a sensor for measuring the amount of radiation that is incident on the accommodation space may be inserted from the outside of the body and accommodated in the body (Representative drawing: FIG. | 11-13-2014 |
| 20140336440 | INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE - Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed. | 11-13-2014 |
| 20140336441 | ENDORECTAL BALLOON WITH GAS RELEASE LUMEN - A rectal balloon apparatus comprises a shaft having a fluid passageway extending therethrough. A rectal gas relieving lumen may be positioned with a central shaft for removal of rectal gas. The gas releasing lumen can also or in the alternative be provided along an outer surface of the balloon. A motion detecting sensor and a radiation detecting sensor may be positioned with the balloon, the shaft, and/or the rectal gas release lumen. | 11-13-2014 |
| 20140336442 | HADRON TREATMENT PLANNING WITH ADEQUATE BIOLOGICAL WEIGHTING - Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region. | 11-13-2014 |
| 20140343344 | Radiation Therapy Guided Using Gamma Imaging - Radiation therapy of a lesion within a patient is guided to take into account movement of the lesion caused by respiration and/or cardiac effects by using MRI or other imaging system suitable for locating the lesion to image the patient while on the treatment support and using a gamma imaging system responsive to a radiation source preferentially taken up by the lesion and registered with the MRI so as to monitor movement of the lesion in real time and thus guide the beam of the RT. | 11-20-2014 |
| 20140343345 | Method for Fiducial-less Real-time Tracking in Radiation Treatment of Abdominal Tumors - A method for fiducial-less real-time motion tracking of abdominal tumors based on the correlation between the patient's breathing pattern and the diaphragm/lung border during treatment delivery. This invention utilizes an edge detection technique to delineate the diaphragm/lung border on radiographic images in order to calculate or determine tumor locations in the abdomen. The position of the diaphragm/lung border is synchronized with the breathing pattern obtained from continuous optical monitoring of a patient's respiratory cycle. The real-time optical breathing pattern obtained from monitoring is used to determine or calculate the position of the diaphragm/lung border during treatment delivery. The position of the diaphragm/lung border is then used to determine the tumor location in real-time. The target tumor coordinates generated through this process are used by the treatment delivery system to adjust the radiation beam geometry of the treatment delivery system to follow the tumor in real-time and accurately deliver radiation dose. | 11-20-2014 |
| 20140343346 | CHARGED PARTICLE BEAM IRRADIATION DEVICE - A charged particle beam irradiation device configured to irradiate a subject to be irradiated with a charged particle beam, including: an accelerator configured to accelerate charged particles and emit the charged particle beam; a gantry in which an irradiation unit for irradiating the subject with the charged particle beam is disposed; an irradiation table on which the subject is positioned; and a transportation line that includes an energy selection system for adjusting energy of the charged particle beam, and transport the charged particle beam to the irradiation unit from the accelerator. The transportation line is linearly formed up to the gantry from the accelerator, and at least a part of the energy selection system is disposed in the gantry, and a shield member configured to shield a radiation beam is provided between the energy selection system, which is disposed in the gantry, and the irradiation table. | 11-20-2014 |
| 20140343347 | METHODS AND RELATED COMPOSITIONS FOR THE TREATMENT OF CANCER - A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer. The agents identified cause increased intracellular granularity in the cancer cells, and also convert adherent cancer cells to non-adherent cancer cells, leading to cancer cell death. Using the present invention, cancer cells undergo increased intracellular granularity at relatively low agent concentrations, while also inhibiting cell proliferation. Increased concentrations lead to conversion of adherent cancer cells to non-adherent cancer cells, then to cell death. While the exact mechanism of cancer cell degradation and death is not completely understood, the treated cancer cells, including refractory prostate cancer cells, give indications of cell death through an autophagic mechanism. Pharmaceutical compositions related to the presently disclosed methods are also disclosed. | 11-20-2014 |
| 20140350322 | INTENSITY-MODULATED PROTON THERAPY - The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites. | 11-27-2014 |
| 20140350323 | Particulate System For Use in Diminishing Cell Growth/Inducing Cell Killing - The Invention relates to a particulate system for use in diminishing cell growth, in particular the growth of cancer cells, comprising one or more water soluble lanthanide compounds that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof. | 11-27-2014 |
| 20140350324 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - A scanning power source that outputs the excitation current for a scanning electromagnet and an irradiation control apparatus that controls the scanning power source; the irradiation control apparatus is provided with a scanning electromagnet command value learning generator that evaluates the result of a run-through, which is a series of irradiation operations through a command value for the excitation current outputted from the scanning power source, that updates the command value for the excitation current, when the result of the evaluation does not satisfy a predetermined condition, so as to perform the run-through, and that outputs to the scanning power source the command value for the excitation current such that its evaluation result has satisfied the predetermined condition. | 11-27-2014 |
| 20140357930 | Gantry Structure For A Hadron Therapy Apparatus - A gantry structure ( | 12-04-2014 |
| 20140357931 | PROGRAMMABLE SEGMENTED VOLUMETRIC MODULATED ARC THERAPY FOR RESPIRATORY COORDINATION - The invention designs a segmented short-arc VMAT plan, modified from the original VMAT plan, to fit the breath-hold interval. The modified VMAT of the invention has the advantages of its applicability to different planning systems for variously long arcs and its preprogrammed arc segmentation for summated dose consistency. The present invention provides a method and a system for use in administering radiation therapy to patients using a radiotherapeutic apparatus with gantry rotation, and also meets the requirements for dose planning and accurate delivery, as well as coordinates patient's breath-hold level. | 12-04-2014 |
| 20140364677 | ROTATING GANTRY AND PARTICLE BEAM THERAPY SYSTEM - A rotating gantry is characterized in that a shielding material for attenuating a leakage dose of a secondary radiation generated by collision of a charged particle beam with an irradiation subject is provided at a position that is situated at the side opposed to a particle beam irradiation apparatus with respect to the irradiation subject and through which a beam axis of the charged particle beam passes, and wherein the shielding material is disposed in such a way that when the irradiation subject does not exist in the rotating gantry, a beam axis portion thereof that intersects the beam axis of the charged particle beam, is attachable and detachable, or can move in a sliding manner and in the rotation-axle direction of the rotating gantry. | 12-11-2014 |
| 20140371511 | PARTICLE ACCELERATOR THAT PRODUCES CHARGED PARTICLES HAVING VARIABLE ENERGIES - An example synchrocyclotron includes the following: a voltage source to provide a radio frequency (RF) voltage to a cavity to accelerate particles from a particle source; a coil to receive a variable electrical current and to generate a magnetic field that is at least 4 Tesla to cause the particles to move orbitally within the cavity; and an extraction channel to receive the accelerated particles and to output the received particles from the cavity. The particles that are output from the cavity have an energy that is variable based at least on the variable electrical current applied to the coil. | 12-18-2014 |
| 20140371512 | REMOTE CONTROL SYSTEM AND METHOD - A remote control system is configured to support communication between a first environment having a first neutron radiation level and a second environment having a second neutron radiation level includes a first computing device and a second computing device. The first computing device is configured to control a treatment system in the first environment. The second computing device is configured to issue commands in the second environment for the treatment system. The first computing device is further configured to determine whether to enable or disable a function supported by the treatment system, determine whether there is pending time-sensitive data to transmit, and periodically transmit a first radiation therapy data collected in the first environment and a first interrupt to the second computing device in a servo loop. | 12-18-2014 |
| 20140371513 | TREATING A TARGET'S PARTIAL MOTION RANGE - A computing system determines a full motion range of a target, wherein the full motion range of the target defines an internal target volume (ITV). The computing system identifies a partial motion range of the target, wherein the partial motion range is a subset of the full motion range of the target. The computing system generates a partial-ITV based on the identified partial motion range, wherein the partial-ITV is a volume swept by the target as the target moves through the partial motion range, the partial-ITV being smaller than the ITV. The computing system generates a treatment plan to deliver treatment to the partial-ITV. | 12-18-2014 |
| 20140378736 | METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR GENERATING A RADIATION THERAPY TREATMENT PLAN - Methods, systems and computer-readable storage media relate to generating a treatment plan for a patient having a patient record. The methods, systems, and the computer-readable storage medias according to embodiments can automatically generate a treatment plan for the patient using (reference) records from previous plans. The system may include: a comparison module configured to compare anatomical information of a plurality of reference records and the patient record; a comparison quantification module configured to determine a metric corresponding to a degree of matching between each reference record and patient record; a reference record selection module configured to select a reference record from the plurality of reference records based on the metric; and a treatment plan generation module configured to generate a treatment plan for the patient based on the selected reference record. | 12-25-2014 |
| 20140378737 | MULTI-OBJECTIVE RADIATION THERAPY SELECTION SYSTEM AND METHOD - A system for facilitating creation of a patient treatment plan includes components configured to receive at least one feature associated with patient data and search a database of previously planned radiation treatments to identify one or more matching plans from the database based on the at least one feature. Parameters corresponding to the identified matching treatment plans may be used to facilitate creation of the patient treatment plan. | 12-25-2014 |
| 20150011817 | System and Method for Delivering an Ultra-High Dose of Radiation Therapy - Ultra high dose rate approach was proposed to irradiate to a moving target in radiation therapy in which the prescribed radiation dose was delivered within such a short time period that the displacement of the target could be ignored during dose delivering. The advantages of the approach were evaluated based on normal tissue sparing, flexibility of accuracy of targeting, and time saving in clinical treatment. A system and method of generating of ultra high dose rate combines and utilizes both a linear accelerator and a storage ring. | 01-08-2015 |
| 20150011818 | TUMOR VESSEL EMBOLIZING AGENT AND METHOD OF EMBOLIZING TUMOR VESSEL - The present disclosure provides a tumor vessel embolizing agent, including: unmodified gold nanoparticles; and a pharmaceutically acceptable medium. The present disclosure also provides a method of embolizing tumor vessel, including administrating gold nanoparticles as a tumor vessel embolizing agent into a subject to accumulate the gold nanoparticles at a tumor in the subject and to embolize a vessel of the tumor. | 01-08-2015 |
| 20150018595 | TREATMENT SYSTEM, CONTROL DEVICE AND TREATMENT METHOD - According to an embodiment, a treatment system includes a plurality of first radiators, a plurality of detectors, a determiner, and a controller. Each of the first radiators irradiates a radioactive beam to a subject. Each of the detectors detects a radioactive beam transmitted through the subject and generates an image based on the detected radioactive beam. The determiner determines whether an object in the subject is included in a first region using a given image that is one of the images. The controller controls the first radiators so that, when the object is not included in the first region, a smaller amount of radioactive beams is irradiated per unit time than when the object is included in the first region. | 01-15-2015 |
| 20150018596 | SYSTEM FOR PLANNING RADIATION TREATMENT THERAPY - A system for planning radiation treatment therapy is provided. An optical sensor device is implanted within or in close proximity to a risk region within the patient during a radiation delivery. The sensor device optically monitors the orientation of the risk region, and the radiation dosage received by the risk region, during the radiation delivery. That information may be used as appropriate to modify an on-going radiation delivery plan in real time while the plan is being implemented. | 01-15-2015 |
| 20150025295 | MEDICAL TREATMENT APPARATUS, CONTROL DEVICE AND CONTROL METHOD - According to an embodiment, a medical treatment apparatus includes: a first acquirer to acquire a group including five or more pairs of corresponding points on a first perspective image of a subject captured at a first timing and a second perspective image of the subject captured at a second timing; a second acquirer to acquire a first parameter including position/orientation information of an imaging device capturing the first perspective image and conversion information related to a coordinate system of the first perspective image, and acquire a second parameter including position/orientation information of an imaging device capturing the second perspective image and conversion information related to a coordinate system of the second perspective image; a calculator to calculate difference in position of the subject between the first timing and the second timing using the group and the parameters; and a controller to control a subject position using the difference. | 01-22-2015 |
| 20150031931 | PARTICLE BEAM IRRADIATION SYSTEM AND METHOD FOR OPERATING THE SAME - A control data about the devices constituting the synchrotron are formed by an initial acceleration control data item, a plural extraction control data items, a plural energy change control data items connecting the plural extraction control data items, and a plural deceleration control data items corresponding to the plural extraction control data items. An affected part position detection unit and an extraction permission determination unit are provided to determine whether the position of a marker shown in transparent image information is included within a beam irradiation permission range. If the marker position is found included, the extraction permission determination unit outputs to an interlock system an extraction permission determination signal permitting beam extraction. | 01-29-2015 |
| 20150031932 | Method to Accurately and Rapidly Locate Tumor - A method to accurately and rapidly locate tumor, comprising the steps of using a immobilization module to ensure the consistency of patient positioning, verification and the position of each treatment; using a locating and marking module comprising a locating and marking tool for locating and marking; using a data input module to obtain the data required for a calculation of Optical Positioning System in radiotherapy; and using a positioning module to calculate the deviation between the planned isocenter and the machine isocenter, and to provide prompts of patient positioning. | 01-29-2015 |
| 20150031933 | RANGE SHIFTER AND PARTICLE RADIOTHERAPY DEVICE - There is provided a range shifter which includes a transmissive plate whose thickness has been adjusted depending on a setup value of an amount of energy to be attenuated, and a holder portion that holds the transmissive plate, wherein the thickness of the transmissive plate is adjusted to be a thickness equivalent to an attenuation amount lower than the setup value by a predetermined rate thereof; and wherein, a superimposing mechanism capable of releasably superimposing an adjustment sheet over the transmissive plate, is provided to at least one of the transmissive plate and the holder portion, the adjustment sheet being adjusted to have a thickness equal to or less than a thickness equivalent to a two-fold attenuation amount of the predetermined rate. | 01-29-2015 |
| 20150031934 | GANTRY-TYPE PARTICLE BEAM IRRADIATION SYSTEM AND PARTICLE BEAM THERAPY SYSTEM COMPRISING SAME - In gantry type particle beam irradiation system comprising a gantry and being configured to irradiate a particle beam, which has small emittance in X direction and large emittance in Y direction at an extraction position of a circular accelerator, from an irradiation nozzle installed in the gantry to an irradiation target, the irradiation nozzle has a ridge filter which is installed so as for a direction in which emittance in X direction is maintained to tilt to a direction which is perpendicular to a ridge of the ridge filter by a predetermined angle in the state where the gantry is a reference angle. | 01-29-2015 |
| 20150038761 | GRAPHENE-AU NANOPLATE STRUCTURE, METHOD FOR FABRICATING THE SAME, AND METHOD FOR ACCELERATING CARBON IONS USING THE GRAPHENE-AU NANOPLATE STRUCTURE - A graphene-Au nanoplate structure, a method for fabricating the same, and a method for accelerating carbon ions using the graphene-Au nanoplate structure. The graphene-Au nanoplate structure includes: a substrate; an Au nanoplate attached on the substrate; and a graphene wrapped around the Au nanoplate. | 02-05-2015 |
| 20150038762 | METHOD FOR PREPARING AN IRRADIATION PLAN FOR A MOVING TARGET VOLUME WITHOUT A MOVEMENT COMPENSATION - A method for preparing a radiation treatment plan for irradiating a target volume region moving in regions in an object with a moving particle beam includes determining, using a mapping function dependent on a movement state (k) of the moving target volume region, a dose input in at least one target point volume (Vj). The dose input is brought about by applying the particle beam to an irradiation point (Bi). | 02-05-2015 |
| 20150038763 | RADIOTHERAPY EQUIPMENT CONTROL DEVICE, RADIOTHERAPY EQUIPMENT CONTROL METHOD, AND PROGRAM EXECUTED BY COMPUTER FOR RADIOTHERAPY EQUIPMENT - A radiotherapy equipment control device acquires reference position information for a specific location at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information. In this case, representative point reference position information and representative position information are generated on the basis of the position information and reference position information for the plurality of markers, said information having been weighted by weighting factors. | 02-05-2015 |
| 20150038764 | CHARGED PARTICLE BEAM TRANSPORT SYSTEM AND PARTICLE BEAM THERAPY SYSTEM - A charged particle beam transport system is characterized in that in a fixed transport unit, a phase of a phase space distribution of a charged particle beam at an inlet of a rotating deflection unit that rotates around an gantry rotation axle of a rotating gantry coincides with a phase determined by a calculation based on an average value of a first phase advance and a second phase advance. The first phase advance is defined as a change in a phase, of the phase space distribution, that changes when the charged particle beam travels from the inlet of the rotating deflection unit to an isocenter in the case where a gantry angle is a gantry reference angle; the second phase advance is defined as a change in a phase at a time when the gantry angle is pivoted by 90° from the gantry reference angle. | 02-05-2015 |
| 20150038765 | USING DIFFERENT INDICATORS FOR DETERMINING POSITIONAL CHANGES OF A RADIOTHERAPY TARGET - The present invention relates to a method for determining data referred to as target change data which can be used for performing radiotherapy treatment, the target change data describing information on the change of position of a target included in a body of a patient, the method being performed by a computer and comprising the following steps:
| 02-05-2015 |
| 20150038766 | PARTICLE BEAM SCANNING IRRADIATION SYSTEM - A particle beam scanning irradiation method includes the steps of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose determined from a particle-beam therapy plan; simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and irradiating the irradiation spot with the particle beam, on the basis of the converted count value. | 02-05-2015 |
| 20150038767 | ENDORECTAL BALLOON WITH GAS LUMEN AND STOPPER - A prostate immobilizing balloon having a central seating area that on full inflation cups the prostate to hold it during treatment is combined with a gas lumen, a locking member and one or more fiducial markers. Methods of using same are also provided. | 02-05-2015 |
| 20150045604 | SYSTEM AND METHOD FOR PATIENT-SPECIFIC MOTION MANAGEMENT - A medical method includes: determining a first probability density function related to a first uncertainty in hitting a target in a treatment of the target; determining a second probability density function related to a second uncertainty, wherein the first uncertainty is attributable to a first source of uncertainty, and the second uncertainty is attributable to a second source of uncertainty that is different from the first source of uncertainty; processing at least the first probability density function and the second probability density function using a processing unit; and outputting a result of the processing. | 02-12-2015 |
| 20150045605 | MEDICAL IMAGE PROCESSING APPARATUS, MEDICAL IMAGE PROCESSING METHOD, AND RADIOTHERAPY SYSTEM - A medical image processing apparatus includes: a receiver which receives target image data that is including a first perspective image and a second perspective image, photographing an object from different directions; a first acquirer which acquires positional information of a specified point on the first perspective image; a second acquirer which acquires positional information of a candidate point on the second perspective image, the candidate point corresponding to the specified point; and a generator which generates a first enlarged image obtained by enlarging a part of the first perspective image neighboring the specified point and a second enlarged image obtained by enlarging a part of the second perspective image neighboring the candidate point. | 02-12-2015 |
| 20150051434 | METHOD FOR REGULARIZING APERTURE SHAPE FOR MILLING - A therapy system ( | 02-19-2015 |
| 20150057484 | ION ACCELERATION COMPLEX FOR THE TREATMENT OF ATRIAL FIBRILLATIONS | 02-26-2015 |
| 20150057485 | POSITIONING SYSTEM FOR RADIOTHERAPY TREATMENT - An apparatus for placement of an optical marker for radiotherapy onto a surface, wherein the optical marker has a reflective element positioned on a body having an outline and shaped and configured such that the reflective element is in a predetermined position relative to the outline of the body, the apparatus comprising a sheet of material having a hole therethrough which is shaped and configured to conform to the outline of the body and which has an upper surface with markings thereon configured for aligning with an image projected onto the surface on which the optical marker is to be placed. | 02-26-2015 |
| 20150057486 | COMPOSITIONS AND METHODS FOR SENSITIZING A NEOPLASTIC CELL TO RADIATION - The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent. | 02-26-2015 |
| 20150065776 | INCREASED RADIOTHERAPY PATIENT THROUGHPUT - A system and method for radiotherapy patient throughput is described. The system includes carts for supporting and moving patients between stations. A mounting and immobilization station allows mounting and immobilizing the patients on the carts. A registration station produces imaging data related to the patients. A waiting station provides waiting space for the carts. A treatment station irradiates the patients on the carts according to a treatment plan. A dismounting station allows releasing and dismounting the patients from the carts. | 03-05-2015 |
| 20150065777 | RADIATION THERAPY MACHINE WITH REAL-TIME EBT IMAGING - The present invention provides a radiation therapy machine using electron beam tomography to provide rapid real-time measurement of radiation therapy target movement. The electron beam therapy may be mounted on a gantry to move with the radiation therapy head or both the megavoltage and kilovoltage radiation needed for radiation therapy and tomography may be implemented by a single combined electron beam tube. | 03-05-2015 |
| 20150065778 | RADIOTHERAPY PATIENT-POSITIONING SHELL - The present invention discloses a radiotherapy patient-positioning shell, which comprises a low-temperature thermoplastic board fabricated to have different positioning zones for different regions of the human body. Each positioning zone has holes. Different positioning zones respectively have different layout densities of the holes. The radiotherapy patient-positioning shell of the present invention has optimized structure and superior usability. The layout densities of different positioning zones of the radiotherapy patient-positioning shell are varied according to requirements of different regions of the human body. Thereby, different positioning zones will have different degrees of contraction and apply different intensities of fixing force to the related body regions. Thus is promoted the comfort of the user and prolonged the service life of the radiotherapy patient-positioning shell without affecting the fixing force thereof. | 03-05-2015 |
| 20150065779 | TREATMENT PLANNING DEVICE, TREATMENT PLANNING METHOD, AND PROGRAM THEREFOR - This treatment planning device calculates position information for specific locations for a plurality of times corresponding to a time course on the basis of the positions of markers positioned in the vicinity of the specific locations, and generates a three-dimensional range for the specific locations for each of the plurality of times. In addition, the treatment planning device generates representative range information, which represents a range that includes the entire three-dimensional ranges for the specific locations for each of the plurality of times, tracks the position information for the specific locations for each of the plurality of times, and calculates the amount of radiation to be emitted in the range for the specific locations represented by representative range information when radiation is emitted for a prescribed time period in the range for the specific locations represented by the representative range information. | 03-05-2015 |
| 20150065780 | Multi Orientation Cryostats - A multi-orientation cryostat | 03-05-2015 |
| 20150065781 | COMBINATION THERAPY FOR THE TREATMENT OF GLIOBLASTOMA - This invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic. | 03-05-2015 |
| 20150073199 | HIGH-FREQUENCY CONTROL DEVICE FOR ACCELERATOR AND PARTICLE BEAM THERAPY SYSTEM - A hard disk drive memory which stores pattern data of a high-frequency to be applied for each combination of energy and intensity of the generated particle beam and a local memory, which reads a plurality of pattern data of a high-frequency for each patient together with a sequential order of changing energy and intensity from the hard disk drive memory and stores data in order to perform a scanning irradiation method in which a layered particle beam irradiation region in a depth direction of an affected part of the patient is formed sequentially by changing energy and intensity of the particle beam sequentially to irradiate an affected part of a patient which is an irradiation subject with the particle beam, and which reads out data faster than the hard disk drive memory are provided. | 03-12-2015 |
| 20150073200 | HADRON TREATMENT PLANNING WITH ADEQUATE BIOLOGICAL WEIGHTING - Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region. | 03-12-2015 |
| 20150080631 | PARTICLE BEAM SCANNING IRRADIATION SYSTEM - A particle beam scanning irradiation system includes a computer establishing a scanning sequence for irradiation of a tumor portion in a patient; and a particle beam irradiation device irradiating the tumor portion in accordance with the established scanning sequence of the particle beam. The computer selects all conceivable combinations of pairs of irradiation spots among the plurality of irradiation spots arranged in the tumor portion, and determines whether each path for the particle beam to shift between two spots constituting the selected pair passes through the tumor portion; determines a penalty matrix expressing whether each path passes through the tumor portion on the basis of the determination result; evaluates a function for the shift paths on the basis of an optimizing algorithm, and establishes the scanning sequence of the particle beam by an optimized solution of the function. | 03-19-2015 |
| 20150080632 | MARINOPYRROLE DERIVATIVES AS ANTICANCER AGENTS - Marinopyrrole derivatives and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing cancer. | 03-19-2015 |
| 20150080633 | SYSTEMS AND METHODS OF CONTROLLING A PROTON BEAM OF A PROTON TREATMENT SYSTEM - Systems and methods of controlling a proton beam in a proton therapy system, the system including a proton beam delivery system including at least one achromatic beamline having a first power setting to direct a proton beam having a first predetermined range of proton beam energies to a target treatment area, and a second power setting to direct a proton beam having a second predetermined range of proton beam energies to the target treatment area, and a power changing unit configured to control an energy level of the proton beam and a power setting of the at least one achromatic beamline such that the power changing unit changes the power setting of the at least one achromatic beamline between the first power setting and the second power setting based on changes in proton beam energy that occur within the first predetermined range of proton beam energies. | 03-19-2015 |
| 20150080634 | TRACKING EXTERNAL MARKERS TO INTERNAL BODILY STRUCTURES - Systems and methods of tracking location of an internal bodily structure of a patient in a radiation treatment room, including a fiducial marker having a unique center point, an offset structure detachably connected to the fiducial marker, the offset structure having unique three dimensional offset coordinates relative to the center point, a means for detachably mounting the offset structure to the patient, an imaging unit to measure location information of the offset structure relative to a target internal bodily structure of the patient, and a detection unit to detect location information of the offset structure and to calculate an offset distance between the target internal bodily structure and the center point. | 03-19-2015 |
| 20150087879 | BENCHMARK SYSTEM FOR RADIATION THERAPY PLANNING - A system for evaluating radiation treatment planning generates a fictitious treatment dose matrix with a quality of dose placement beyond that achievable with physically realizable radiation therapy machines. Such a fictitious treatment dose matrix provides an objective measure that is readily tailored to different clinical situations, and although unattainable, thereby provides a benchmark allowing evaluation of radiation plan goals and the radiation plans between different multiple clinical situations and individuals. | 03-26-2015 |
| 20150087880 | USE OF A COMPOSITION COMPRISING A POLY-ORGANOSILOXANE - A composition based on a poly-organosiloxane which is suitable for its use as a bolus in radiotherapy treatments. Other possible uses of this composition are the production of an immobilizing mask for radio surgery or cranial stereotaxy treatments and the production of an intraoral depressor. | 03-26-2015 |
| 20150087881 | RADIOTHERAPY CONTROL APPARATUS AND RADIOTHERAPY CONTROL PROGRAM - [Problem to be Solved] | 03-26-2015 |
| 20150087882 | METHOD AND APPARATUS FOR MONITORING THE RANGE OF A PARTICLE BEAM - The invention is related to a method for monitoring a range of a particle beam in a target. The method is using gamma detectors for detecting prompt gammas produced in the target. The time differences between the time of detecting a gamma quantum and a time of emission of a particle or a bunch of particles from the radiation device are determined. A statistical distribution of those time difference is used to deduce information related to the range of the beam. The invention is also related to an apparatus for monitoring a range based on measured time profiles of detected prompt gammas. | 03-26-2015 |
| 20150087883 | TREATMENT THEATER FOR PROTON THERAPY - A theater system for a proton treatment system, including a tunnel structure configured around an isocenter of a proton treatment system, and one or more devices mounted on the tunnel structure to communicate with a patient located on a treatment bed of the proton treatment system. | 03-26-2015 |
| 20150087884 | RIGID APPARATUS TO REPLACE BEAM STEERING - A proton beam delivery system including a proton beam nozzle to emit a proton beam to a targeted region of a patient, a gantry wheel to support the proton beam nozzle, the gantry wheel being configured to rotate the proton beam nozzle about a rotation axis of the gantry wheel such that the proton beam nozzle emits the proton beam to an isocenter of the gantry wheel corresponding to the targeted region, a beamline deflector configured to be rotated by the gantry wheel to transport the proton beam along a curvilinear path from the rotation axis to the proton beam nozzle using a predetermined power setting of the beamline deflector, and a rigid support structure to support the beamline deflector when the gantry wheel is rotated such that the beam nozzle directs the proton beam to the isocenter from a plurality of radial directions using the same predetermined power setting. | 03-26-2015 |
| 20150087885 | Method and Apparatus for Measuring, Verifying, and Displaying Progress of Dose Delivery in Scanned Beam Particle Therapy - The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis. | 03-26-2015 |
| 20150087886 | NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER - This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical bifunctional inhibitors of DNA replication and repair proteins Metnase and/or Intnase (also termed Gypsy Integrase, Gypsy Integrease-1, Gypsy Retransposon Integrase 1, or GIN-1) that simultaneously damage DNA, and to a therapeutic method that utilizes the inhibitors to increase the effectiveness of cancer treatment protocols, including radiation therapy. | 03-26-2015 |
| 20150087887 | MULTI-LEAF COLLIMATOR, PARTICLE BEAM THERAPY SYSTEM, AND TREATMENT PLANNING APPARATUS - There are provided a leaf row in which a plurality of leaf plates are arranged in the thickness direction of the row in such a way that the respective one end faces of the leaf plates are trued up and a leaf plate drive mechanism that drives each of the plurality of leaf plates in such a way that the one end face approaches or departs from a beam axis. In each of the leaf plates, a facing side facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane including a first axis on the beam axis; the leaf plate drive mechanism drives the leaf plate along a circumferential orbit around the second axis, on the beam axis, that is perpendicular to the beam axis and the first axis. | 03-26-2015 |
| 20150094513 | Apparatus and Method for Combining Machine Limitations Information with Target Motion Boundary Information - A control circuit accesses machine limitations information and target motion boundary information. The control circuit then combines the machine limitations information with the target motion boundary information when acting with respect to a radiation treatment plan. By one approach the control circuit acts with respect to a radiation treatment plan by presenting machine limitation information in combination with target motion boundary information. As another approach, the control circuit acts by combining the foregoing information while developing the radiation treatment plan to use that information to make automatic adjustments to the radiation treatment plan to correct instances where a planned configuration reveals a conflict between the physical limitations of the treatment platform and the target motion boundary. | 04-02-2015 |
| 20150094514 | SYSTEM AND METHODS FOR PROCESSING IMAGES TO MEASURE MULTI-LEAF COLLIMATOR, COLLIMATOR JAW, AND COLLIMATOR PERFORMANCE - Systems and methods are proposed for accurate and efficient automatic measurement of jaw and leaf positioning in multi-leaf collimator imaging systems. Specifically, the method enables the automated and objective processing of images to determine characteristics of collimator jaws and MLC leaves. These novel techniques enable verification of collimator component positioning to ensure accurate beam modulation for radiation therapy procedures. | 04-02-2015 |
| 20150094515 | SYSTEM AND METHOD FOR RADIATION THERAPY TREATMENT PLANNING USING A MEMETIC OPTIMIZATION ALGORITHM - A method for the optimization of radiation therapy treatment plans is disclosed. The disclosed method is equally-applicable to robotic radiosurgery as well as other types of radiosurgical delivery, intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and three-dimensional conformal radiotherapy (3DCRT). A population-based heuristic approximation is used to perform a global search, and subsequently, a deterministic local trajectory search is employed to further refine the initial solution. | 04-02-2015 |
| 20150094516 | MEDICAL IMAGE PROCESSING DEVICE, TREATMENT SYSTEM AND MEDICAL IMAGE PROCESSING METHOD - According to an embodiment, a medical image processing device includes a processor, and a memory. The memory that stores processor-executable instructions that, when executed by the processor, cause the processor to execute acquiring a first perspective image of a subject viewed in a first direction; setting a first region and a second region on the first perspective image, the first region including a first group of pixels around a target pixel, the second region including a second group of pixels, the second group including a pixel not included in the first group; calculating a likelihood of the target pixel, wherein the likelihood increases as a difference between pixel values included in the first group decreases and a difference between pixel values of the first group and the second group increases; and detecting a position of an object in the subject based on the likelihood. | 04-02-2015 |
| 20150094517 | CHARGED HADRON BEAM DELIVERY - A charged hadron therapy system for delivering charged hadron radiation to a target is provided. The system comprises a target positioning couch for supporting the target being moveable along a translation direction and a beam delivery system comprising a beam scanning means for scanning a hadron pencil beam over said target in a first scanning direction and a second scanning direction being substantially parallel with the translation direction. The beam scanning means is limited for providing a maximum scanning amplitude AY in the second scanning direction. The system comprises an irradiation controller configured for simultaneously and synchronously performing the moving of the couch and the scanning, so as to deliver charged hadron radiation to a target over a target size being larger in the Y direction than the maximum scanning amplitude AY. | 04-02-2015 |
| 20150094518 | MODULAR POLYMER PLATFORM FOR THE TREATMENT OF CANCER - The invention provides a novel polymer platform to deliver a desired combination of therapeutic agents to a site in need thereof for the treatment of cancer. In certain embodiments the platform is a modular polymer platform that allows for customization based upon the tumor of the subject to be treated. | 04-02-2015 |
| 20150094519 | PREDICTING ACHIEVABLE DOSE DISTRIBUTION USING 3D INFORMATION AS AN INPUT - Knowledge-based radiotherapy treatment planning is expanded to include spatial information from, for example, positron emission tomography (PET). Information that is specific to a patient is accessed. A prediction of a spatial dose distribution inside a target volume in the patient is determined using the patient-specific information as an input to a prediction model. The prediction model is established using training data that includes data resulting from applying other radiation treatment plans to other patients. The training data includes spatially distributed information indicating a level of activity in target volumes in the other patients (e.g., PET image data). A dose-volume histogram and associated three-dimensional dose distribution information based on the prediction are produced. The dose-volume histogram and the three-dimensional dose distribution information can be used to develop a radiation treatment plan for the patient. | 04-02-2015 |
| 20150094520 | METHOD OF INHIBITING C-KIT KINASE - A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: | 04-02-2015 |
| 20150099916 | HEAD IMMOBILIZATION DEVICE WITH INHALER, METHOD FOR MAKING SAME AND METHOD OF USING SAME - Head and neck radiation therapy for the treatment of cancer or the like is carried out using a mask which comprises a heat-softenable, conformable and perforate plastic sheet and a frame which can be secured to the surface of a treatment table or chair to immobilize the patient's head and neck. An inhaler is placed on the patient's face prior to molding the thermoplastic sheet over the patient's face such that the resulting contoured sheet captures the inhaler and produces a unitary assembly. Inlet and outlet hoses can be attached to the inhaler for administering an anesthetic or soporific in gaseous form, such as nitrous oxide, for the purpose of calming and tranquilizing the patient for reducing feelings of claustrophobic anxiety during the treatment. A separate scavenging unit may be added. | 04-09-2015 |
| 20150099917 | SYSTEM FOR THE DELIVERY OF PROTON THERAPY BY PENCIL BEAM SCANNING OF A PREDETERMINABLE VOLUME WITHIN A PATIENT - A system and a method improve a quality of beam delivery in proton therapy by pencil beam scanning of a predeterminable volume within a patient that minimizes beam position errors. The system has a proton source generating a proton beam, a number of proton beam bending/focusing units, a beam nozzle having an outlet for the proton beam to penetrate the predetermined volume, a beam bending magnet, and a couple of sweeper magnets to sweep the proton beam in both lateral directions. A position-sensitive detector is aligned with the nozzle to control the position of the proton beam and control logic controls the position and the energy of the proton beam and has a beam steering data set. A correction logic is aligned with the control logic for correcting beam position errors by comparing an expected beam position with the actual beam position detected and generates beam position correction data. | 04-09-2015 |
| 20150099918 | RADIATION MEASURING DEVICE, PARTICLE BEAM THERAPY DEVICE PROVIDED WITH RADIATION MEASURING DEVICE, AND METHOD FOR CALCULATING DOSE PROFILE OF PARTICLE BEAM - A radiation measuring device having a plurality of sensors configured to generate charges in response to the radiation includes a signal processing device. The signal processing device uses an signal generated by a proton beam irradiation device upon changing of beam energy and causes accumulation values of charges output from the sensors to be separately stored in a main control device for each value of the energy. The main control device calculates depth dose profiles for values of the beam energy from the accumulation values stored in the main control device and representing the charges. The main control device calculates a range of the beam for each of the values of the beam energy from the depth dose profiles, corrects the depth dose profiles for the values of the beam energy using a correction coefficient that depends on the range and sums the corrected depth dose profiles. | 04-09-2015 |
| 20150105601 | RADIOACTIVE EPOXY IN OPHTHALMIC BRACHYTHERAPY - An ophthalmic radiation device using a polymeric radiation-source implemented as either a polymer molecularly bonded with a radioisotope or a polymeric encasement of a radioisotope. | 04-16-2015 |
| 20150105602 | POLYMERIC RADIATION-SOURCES - A polymeric radiation-source with customized geometries to maximize receipt of radiation into treatment areas that is formed from either radioisotopes molecularly bonded to a polymer or radioisotopes encased within a polymer. | 04-16-2015 |
| 20150105603 | MICROFABRICATED SCINTILLATION DETECTOR - The present invention discloses a microfabricated scintillation detector, comprising a channel structure ( | 04-16-2015 |
| 20150105604 | FILTER AND NEUTRON BEAM SOURCE INCLUDING THE SAME - Disclosed is a filter including a second layer disposed between a first layer and a third layer. The first layer is composed of iron. The second layer is composed of 1 part by volume of lithium fluoride, 20 to 50 parts by volume of aluminum, and 50 to 80 parts by volume of aluminum fluoride. The third layer is composed of 1 part by weight of lithium fluoride and 99 to 100 parts by weight of magnesium fluoride. | 04-16-2015 |
| 20150112116 | TYROSINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM - Provided herein are methods comprising providing a tyrosine derivative and a solid particulate material (and, optionally, melanin) and applying force to said tyrosine derivative and said solid particulate material for a time and under conditions effective to impregnate at least one of said tyrosine derivative and said solid particulate material with the other of said tyrosine derivative and said solid particulate material. The invention also provides compositions comprising at least one of a tyrosine derivative impregnated with a solid particulate material and a solid particulate material impregnated with a tyrosine derivative. | 04-23-2015 |
| 20150112117 | DIAGNOSTIC OR THERAPEUTIC PROCEDURE USING IMPLANTABLE TARGETS - An implantable device has a body that is substantially rigid and has an imageable shape. The body is further bioabsorbable and may contain permanent metallic elements to aid in its imaging. When the device is implanted in a resected cavity in soft tissue, it can cause the cavity to conform substantially to a known imageable shape. The implantable device is further imageable due to its attenuation properties being different from those of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined. | 04-23-2015 |
| 20150119624 | NANOPARTICLES WITH ATTACHED DNA REPAIR INHIBITORS AND NUCLEAR LOCALISATION SIGNAL ELEMENTS - A radio- or chemo-sensitizing compound is described herein. The compound comprises a nanoparticle and attached to the nanoparticle;
| 04-30-2015 |
| 20150119625 | USE OF ANCILLARY DEVICES/ACCESSORIES IN RADIOTHERAPY SYSTEMS - A system or use with a radiotherapy system includes a scanner for producing images of at least one object within an imaging volume, a radiotherapy apparatus including a source of therapeutic radiation adapted to deliver a beam of radiation into the at least one object, a treatment planning system for controlling the source so as to deliver radiation in accordance with a predetermined plan for treating a patient and with the images of the at least one object, and at least one device within and/or adjacent to the imaging volume. The at least one device comprises at least one first marker which is visible to the scanner and at least one MR second marker which is visible to an MR scanner. The system further comprises a database containing data including the markers associated with the at least one device and at least its geometric and density characteristics. | 04-30-2015 |
| 20150119626 | IMAGE GUIDED RADIATION THERAPY APPARATUS - An IGRT apparatus includes a medical imaging device integrated with a linear accelerator, the linear accelerator is configured for emitting a radiation beam, which is shaped by a beam shaper, and a gantry. The position of the beam shaper is adjustable between a first position and a second position; the first position is a treatment position and the second position is a non-treatment position and the first position is within the gantry and the second position is removed from the gantry. | 04-30-2015 |
| 20150119627 | RADIATION THERAPY APPARATUS WITH AN APERTURE ASSEMBLY AND ASSOCIATED METHODS - A radiation therapy apparatus includes a housing, a radiation source carried by the housing, and at least one aperture assembly carried by the housing. The aperture assembly includes a radiation aperture body having a shaped opening therein to control a radiation dosing profile, and an aperture holder with an aperture-receiving passageway therein receiving the radiation aperture body, and having a recessed end. A cover is received within the recessed end of the aperture holder and retains the radiation aperture body within the aperture holder. The cover has an opening aligned with the shaped opening in the radiation aperture body. The radiation aperture body, the aperture receiving passageway of the aperture holder and the opening of the cover have angled interfaces therebetween. A radiation filter is carried by the housing. | 04-30-2015 |
| 20150126796 | PREVENTION OF SETUP ERRORS IN RADIOTHERAPY - A patient safety system (PSS) ( | 05-07-2015 |
| 20150126797 | Method and Device for Bunching a Beam of Charged Particles - A method for packetizing a beam-charged particle, in which the particles pass through an electric field in a device is provided. The device includes an annular shaped central electrode which, in the direction of the beam, is arranged between a first outer electrode and a second outer electrode. A time-dependent electric voltage signal is applied to the central electrode, the temporal course thereof being selected such that particles inside the device undergo a position-dependent speed modification. The course of the speed modification is approximately sawtooth-shaped in the direction of the beam. An associated device is also provided. | 05-07-2015 |
| 20150126798 | CONTROL DEVICE FOR SCANNING ELECTROMAGNET AND PARTICLE BEAM THERAPY APPARATUS - A control device (control unit) to be used for controlling a scanning electromagnet that is used for scanning irradiation, which includes: a command-value processing line (a memory, an arithmetic circuit, an interface) that generates a command value for driving the scanning electromagnet on the basis of a treatment plan, and outputs the generated command value in synchronization with an accelerator; and a comparator unit that detects an error in the processing line; wherein a circuit (for example, the arithmetic circuit) that constitutes at least a part of the processing line is made redundant, and the comparator unit detects occurrence of the error in the processing line when outputs from the circuit made redundant are unmatched to each other. | 05-07-2015 |
| 20150126799 | MAGNETIC RESONANCE GUIDED THERAPY WITH INTERLEAVED SCANNING - The present invention relates to a method for controlling a medical apparatus ( | 05-07-2015 |
| 20150126800 | SYSTEM AND METHOD FOR MANAGING RADIATION TREATMENT MACHINE - A management system and method for managing a radiation treatment machine are disclosed herein. The system includes an information acquisition unit, an amount-of-use database, a treatment plan database, and a management unit. The information acquisition unit acquires information about the amount of use of the radiation treatment machine and information about a treatment plan. The amount-of-use database stores the information about the amount of use of the radiation treatment machine. The treatment plan database stores the time at which treatment is to be performed and information about the amount of use of the radiation treatment machine. The management unit checks whether the cumulative amount of use of the radiation treatment machine to exceed a predetermined reference value when the treatment is to be performed. | 05-07-2015 |
| 20150126801 | SYSTEMS AND METHODS OF ADJUSTING A ROTATING GANTRY SYSTEM - A gantry wheel adjustment system and method to adjust a gantry wheel of a proton treatment system, including an estimation unit to estimate a bearing adjustment value for each of the adjustable bearings based on a stiffness parameter of each adjustable bearing, the stiffness parameter being a function of a force applied at each adjustable bearing and a deflection of the gantry wheel associated with the force applied at each adjustable bearing, the bearing adjustment value corresponding to a nominal position value for each adjustable bearing to compensate for gantry wheel flexing when the gantry wheel is rotated from a first angular position to a second angular position, the adjustable bearings being configured to support the gantry wheel on the bearing surface and maintain the proton beam at the isocenter of the gantry wheel during gantry wheel rotation. | 05-07-2015 |
| 20150133713 | Method For Compensating The Deviation Of A Hadron Beam Produced By A Hadron-Therapy Installation - The present invention relates to a method for compensating the deviation of an energetic beam of hadrons delivered by an irradiation unit of a hadron-therapy installation, with respect to an isocentre of a rotatable gantry supporting said irradiation unit, said irradiation unit comprising a collimator comprising an opening for the passage of said beam. The present invention also relates to a program comprising an algorithm for calculation of a correction to be applied to the position of an opening of a collimator of an irradiation unit of a hadron-therapy installation. The invention finally also relates to a hadron therapy installation. | 05-14-2015 |
| 20150133714 | IRRADIATION PLANNING APPARATUS AND CHARGED PARTICLE IRRADIATION SYSTEM - A planning apparatus ( | 05-14-2015 |
| 20150133715 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - When IMRT technology for a radiation therapy system utilizing an X-ray or the like is applied to a particle beam therapy system having a conventional wobbler system, it is required to utilize two or more boluses. The present invention solves the problem of excess irradiation in IMRT by a particle beam therapy system. More specifically, the problem of excess irradiation in IMRT by a particle beam therapy system is solved by raising the irradiation flexibility in the depth direction, without utilizing a bolus. A particle beam irradiation apparatus has a scanning irradiation system that performs scanning with a charged particle beam accelerated by an accelerator and is mounted in a rotating gantry for rotating the irradiation direction of the charged particle beam. The particle beam irradiation apparatus comprises a columnar-irradiation-field generation apparatus that generates a columnar irradiation field by enlarging the Bragg peak of the charged particle beam. | 05-14-2015 |
| 20150141732 | Apparatus And Method For Hadron Beam Verification - The present invention is related to an apparatus and method for hadron beam verification. The apparatus allows to verify a number of different characteristics in a brief time span. The apparatus comprises at least one main degrader element and associated therewith a multiple thickness degrader element. The latter may comprise a number of patches of beam degrading material, the patches having constant but mutually different thicknesses. Alternatively, it may be a wedge-shaped element. By aiming a pencil beam at the various thicknesses, data points can be obtained which allow to make an estimation of the beam range. In addition to this, the apparatus comprises a zone where no degrader material is present, and where a measurement of the spot size can be obtained, without moving or replacing the apparatus. | 05-21-2015 |
| 20150141733 | AUTOMATIC PLAN OPTIMIZATION FOR CHANGING PATIENT ANATOMY IN THE PRESENCE OF MAPPED DELIVERED DOSE FROM DELIVERED FRACTIONS - A therapy planning system and method generate an optimal treatment plan accounting for changes in anatomy. Therapy is delivered to the subject according to a first auto-planned optimal treatment plan based on a first image of a subject. A second image of the subject is received after a period of time. The second image is registered with the first image to generate a deformation map accounting for physiological changes. The second image is segmented into regions of interest using the deformation map. A mapped delivered dose is computed for each region of interest using the dose delivery goals and the deformation map. The first treatment plan is merged with the segmented regions of the second image and the mapped delivered dose during optimization. | 05-21-2015 |
| 20150148584 | INNER GANTRY - A system includes a patient support and an outer gantry on which an accelerator is mounted to enable the accelerator to move through a range of positions around a patient on the patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach a target in the patient. An inner gantry includes an aperture for directing the proton or ion beam towards the target. | 05-28-2015 |
| 20150148585 | COMBINATION THERAPY FOR THE TREATMENT OF GLIOBLASTOMA - This invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic. | 05-28-2015 |
| 20150289948 | METHODS AND MATERIALS FOR ORAL STENTING - This document provides methods and materials related to oral stenting. For example, oral stenting devices (e.g., adjustable oral stenting devices) and methods for using oral stenting devices for radiation therapy are provided. | 10-15-2015 |
| 20150290472 | BLOOD-TISSUE SURFACE BASED RADIOSURGICAL RENAL TREATMENT PLANNING - Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets. | 10-15-2015 |
| 20150290473 | Radiotherapy system - A radiotherapy system comprising a source of radiation, for generating a beam of therapeutic radiation; a field light, for generating a beam of optical light that emulates the beam of therapeutic radiation; and a collimating device, for collimating the beam of therapeutic radiation and the beam of optical light. The field light comprises a single light-emitting diode (LED) having a single die, and wherein the radiotherapy system does not comprise any lenses outside the LED through which the beam of optical light passes. | 10-15-2015 |
| 20150290474 | DETERMINING AN IRRADIATION REGION FOR RADIOTHERAPY BASED ON MODEL PATIENT DATA AND PATIENT IMAGE DATA - The invention relates to a data processing method of determining a radiotherapy treatment plan for radiotherapy treatment of a treatment body part (P) of a patient's body, the method being executed by a computer and comprising the following steps: a) acquiring treatment target position data comprising treatment target position information describing the position of a treatment target (TT | 10-15-2015 |
| 20150290475 | SYSTEM FOR IRRADIATING CHARGED PARTICLES AND METHOD FOR IRRADIATING CHARGED PARTICLES - A charged particle irradiation system is capable of shortening the irradiation time and the treatment time by performing efficient irradiation even when irregular variation occurs in the irradiation object during the gating irradiation. The extraction of the beam is stopped upon reception of a regular extraction permission end signal which is outputted based on a regular movement signal. An extractable state maintaining function operates upon the reception of the extraction permission end signal. When a preset standby time elapses without receiving an extraction permission start signal again during the standby time, the extractable state maintaining function finishes its operation and a charged particle beam generator decelerates the beam. Also, the extraction of the beam is stopped due to reception of an irregular extraction permission end signal during the irradiation. When the extraction permission start signal is received again during the standby time, the extraction of the beam is restarted. | 10-15-2015 |
| 20150291604 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES - The present invention relates to compounds of formula (X) | 10-15-2015 |
| 20150297310 | METHODS FOR SELECTING A TREATMENT FOR CANCER - Biomarkers predictive of a subject's likelihood of responding to an immunotherapy including blockade of PD-1 inhibitory signaling, and method of use thereof are disclosed. The biomarkers are HIF1-alpha, KDR, CXCL13, and IL7R. Exemplary methods include identifying or selecting a subject who may benefit from treatment with an immunotherapy including blockade of PD-1 signaling, and methods of predicting responsiveness of a subject suffering from cancer to treatment with an immunotherapy including blockade of PD-1 signaling. Preferred immunotherapies and methods of treating subjects with cancer are also provided. | 10-22-2015 |
| 20150297872 | APPARATUS AND METHOD FOR AIDING ORGAN TREATMENT - A medical apparatus includes a catheter having an inflatable balloon at its distal end. The balloon defines at least two spaced larger diameter areas defining a valley therebetween and is adapted to be inserted in a non-inflated condition into a cavity of the human body such as the rectum, and when inflated, is adapted to cradle an organ such as the prostate located in a different body cavity. The balloon is symmetric about an axis defined by the catheter so that positioning issues are limited to axial positioning rather than rotational positioning. Because of the valley in the balloon, when the balloon is inflated, only a limited portion of the rectum is necessarily pushed into contact with the prostate, and thus, the radiation toxicity to the rectum is limited. Methods utilizing the medical apparatus are disclosed. | 10-22-2015 |
| 20150297916 | System and Method for the Validation and Quality Assurance of Computerized Contours of Human Anatomy - A system and method for validating the accuracy of delineated contours in computerized imaging using statistical data for generating assessment criterion that define acceptable tolerances for delineated contours, with the statistical data being conditionally updated and/or refined between individual processes for validating delineated contours to thereby adjust the tolerances defined by the assessment criterion in the stored statistical data, such that the stored statistical data is more closely representative of a target population. In an alternative embodiment, a system and method for validating the accuracy of delineated contours in computerized imaging using machine learning for assessing delineated contours, with the machine learning training data being used to generate geometric attributes, and the geometric attributes used to construct intra- and interstructural geometric attribute distribution models to automatically detect contouring errors. The present invention may be used to facilitate, as one example, radiation therapy. | 10-22-2015 |
| 20150297917 | HADRON RADIATION INSTALLATION AND VERIFICATION METHOD - A hadron radiation installation adapted to subject a target to irradiation by a hadron radiation beam includes a target support configured to support, preferably immobilize, a target; a hadron radiation apparatus adapted to emit a hadron radiation beam along a beam axis to irradiate the target supported by the target support, the radiation beam penetrating into the target. The radiation apparatus has a control system at least comprising a beam penetration depth control allowing at least to control and vary the penetration depth of the radiation beam into the target. The installation has a radiation beam range sensor device adapted to determine the penetration depth of said radiation beam into the target, where the range sensor device includes a gamma camera responsive to prompt gamma rays that are emitted while the hadron radiation beam penetrates into the target. | 10-22-2015 |
| 20150297918 | PARTICLE BEAM ROTATIONAL IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - A particle beam rotational irradiation apparatus includes: a frame that supports an irradiation nozzle and rotates; an irradiation-nozzle support member that is provided on an inner-circumference side of the frame and supports the irradiation nozzle; a movable floor that has a roller movable in a circumferential direction centering on a rotation axis of the frame; and a movable-floor rail that is provided in the circumferential direction on the inner-circumference side of the frame and supports the roller; wherein the irradiation-nozzle support member and the movable floor have respective coupling portions that are attachable/detachable to/from each other in the circumferential direction centering on the rotation axis of the frame. | 10-22-2015 |
| 20150299809 | Biomarkers for Clinical Cancer Management - A method is provided for determining breast cancer, a predisposition to breast cancer, or the prognosis of a breast cancer in a subject, said method comprising in a sample from said subject determining the methylation status of at least one gene locus including regulatory sequences of said gene locus, wherein said genelocusis selected from the group consisting of PHOX2B, FLJ3247, GHSR, HOXB13, HTR1B, ONECUT, POU4F, WT1, LHX1, BC008699, BX161496, CA10, NR2E1, SIX6, SLC38A4, TITF, TMTM132D, CRH, NKX2-3 and HMX. | 10-22-2015 |
| 20150306424 | Planning the Irradiation of a Particle Beam While Taking into Consideration a Movement of a Target Volume - A method is disclosed for irradiation planning for the irradiation of a moving target volume located in a body with a particle beam irradiation facility by means of rescanning, which method has the steps of defining the target volume in a reference condition of the motion, dividing the target volume among a plurality of target points that can be individually approached with a particle beam, calculating a nominal dose to be deposited in each of the target points of the target volume, defining a number of rescanning passes in which each of the target points of the target volume are approached, calculating a mean motion to be expected of the target points of the target volume based on a motion model, taking into account the mean motion to be expected of the target points of the target volume in the irradiation planning in such a manner that the deviation of the expected dose deposition from the nominal dose for each target point is determined, and the nominal dose for each target point is corrected on the basis of the deviation, and generation of control parameters for the irradiation facility, wherein the control parameters comprise a particle count per target point and rescanning pass to be applied. | 10-29-2015 |
| 20150309184 | COMMUNICATING RADIOISOTOPE DOSAGE - A method for measuring nuclear radiation in a material includes converting radiation from a material that has been inserted into a chamber into an electrical signal corresponding to an extent of nuclear radiation in the material. An electronic circuit provides to the chamber, and receives an electrical signal from the chamber in response to the presence of radiation in the material. A processor receives the electronic signal from the chamber, and uses software to process the digital data, store it, and communicate it over an electronic network. The processor hosts a web server interface which is operative to generate and host pages for access through the network, where the pages corresponding to the processed digital data. | 10-29-2015 |
| 20150314139 | RADIOTHERAPY APPARATUS - A method for dealing with the effects of inertia in a radiotherapy apparatus is disclosed. The method may include catering for inertia in advance by incorporating inertia factors into an output from a delivery control system which adapts the treatment plan by incorporating the inertia factors, or by including the inertia factors as a constraint in the treatment planning process. The instructions delivered to the geometry items may reflect their inertia behavior and can therefore be followed very closely. This may indicate that a departure from that plan will be correspondingly more likely to indicate an error by the geometry item. When a geometry item needs to accelerate or decelerate, less error may arise and thus the error-checking regime may not necessarily make allowances for such departures from the intended path, thereby tightening the error tolerances. Error-checking may be safely carried out locally for each component. | 11-05-2015 |
| 20150315131 | COMBINATION USES OF DICHLOROACETATE AND OXAMATE, AND THEIR PRODRUGS, FOR CANCER TREATMENT - The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation thereapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways. | 11-05-2015 |
| 20150315656 | Methods and Kits for Monitoring Response to Radiation Therapies in Cancer - A method of evaluating a cancer cell sample, the method comprising: a. obtaining a cancer cell sample, optionally a breast cancer cell sample or an ovarian cancer cell sample, after the cancer cells have been exposed to a radiation dose; b. assaying the cancer cell sample to obtain a RNA integrity value and/or a RNA concentration of the cancer cell sample. | 11-05-2015 |
| 20150320835 | MANIPULATION OF HAIRY AND ENHANCER OF SPLIT 3 (HES3) AND ITS REGULATORS/MEDIATORS AS A NEW ANTI-CANCER STRATEGY - The present invention relates to an inhibitor of Hairy and Enhancer of Split 3 (Hes3) or for use in treating a tumour. The invention further relates to an in-vitro method for diagnosing a tumour, comprising determining the amount of Hes3 protein in a cerebrospinal fluid (CSF)-derived sample obtained from a subject, wherein an increased amount of Hes3 protein is indicative of the presence of a tumour. | 11-12-2015 |
| 20150321025 | APPARATUS FOR PARTICLE THERAPY VERIFICATION COMPRISING A COLLIMATOR WITH MULTIPLE OPENINGS - The disclosure is related to an apparatus and method for charged hadron therapy verification. The apparatus comprises a collimator comprising a plurality of collimator slabs of a given thickness, spaced apart so as to form an array of mutually slit-shaped openings, configured to be placed at a right angle to the beam line, so as to allow the passage of prompt gammas from the target, the collimator being defined at least by three geometrical parameters being the width and depth of the slit-shaped openings and a fill factor. The disclosure is also related to a method for charged hadron therapy verification with a multi-slit camera. | 11-12-2015 |
| 20150328483 | PARTICLE THERAPY APPARATUS - A particle therapy apparatus has a rotating gantry configured in such a way that an irradiation device is rotated around a rotation axis and a particle beam is irradiated onto an irradiation subject; the rotating gantry is provided with an entrance-side deflection electromagnet having a deflection path for radially deflecting the particle beam supplied along the rotation axis so as to guide the particle beam to the irradiation device and a straight path that is switchable with the deflection path and is for making the supplied particle beam travel in a straight manner; there are provided trajectory correcting devices having two position sensors that are arranged along the rotation axis so as to flank the entrance-side deflection electromagnet. | 11-19-2015 |
| 20150335912 | SPLENIC IRRADIATION FOR THE TREATMENT OF NEUROLOGICAL DISORDERS - Irradiation treatment can be used before, during, or after a surgical treatment or other injury to the brain to decrease or prevent subsequent injury. Injury to the brain during surgery can induce the infiltration of peripheral immune cells, including splenic immune cells, into the brain. The infiltration of immune cells can create acute elevations in brain edema and blood-brain barrier disruption thereby decreasing neurological recover and patient outcomes. Irradiation of peripheral immune cells, or the region of the body in which the cells are derived, can allow for inactivation of the cells and prevent infiltration into the surgical site, for example, the brain. | 11-26-2015 |
| 20150335914 | METHODS AND APPARATUS FOR THE PLANNING AND DELIVERY OF RADIATION TREATMENTS - Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity. | 11-26-2015 |
| 20150335915 | CBCT and X-Ray Combined Setup with X-Ray Verification of Patient Positioning - The invention is directed to a data processing method for determining the consistency of registration of the position of a treatment body part to be treated by radiotherapy with a treatment beam arrangement of at least one position of a treatment beam issued by a treatment device, the treatment body part being a soft tissue part of an anatomical structure of a patient's body nad the data processing method being constituted to be executed by a computer and comprising the following steps: g) acquiring CT data comprising predetermined CT information about a position of the treatment body part relative to a bony structure of the patient's body and about a first position of the bony structure relative to the treatment beam arrangement; h) acquiring x-ray data comprising x-ray information about a second position of the bony structure relative to the treatment beam arrangement; i) determining, based on the x-ray data and the CT data, bony structure position first transformation data comprising bony structure position first transformation information about a first transformation between the first position and the second position of the bony structure; j) acquiring CBCT data comprising CBCT information about the position of the treatment body part relative to the treatment beam arrangement or relative to the bony structure; k) determining, based on the CBCT data and the CT data, bony structure position second transformation data comprising bony structure position second transformation information about a second transformation between the first position and a third position of the bony structure relative to the treatment beam arrangement; determining, based on the bony structure position first transformation data and the bony structure position second transformation data, transformation difference data comprising transformation difference information about a difference between the first and second transformations. | 11-26-2015 |
| 20150343238 | CHARGED PARTICLE CANCER THERAPY PATIENT CONSTRAINT APPARATUS AND METHOD OF USE THEREOF - A patient positioning/constraint apparatus and method of use thereof is described in combination with a charged particle cancer therapy system. In one embodiment, a patient is tilted about a longitudinal axis, such as rotation about a head-to-foot axis of the patient where the head-to-foot axis of the patient is horizontal. Optional side support constraints are optionally used to constrain radial movement of the patient on the tilted patient support. The side support constraints are optionally pre-formed to or coupled to a radially outer shape of an individual patient, such as the dexter or sinister side of the individual's head, arm, torso, hip, and/or leg. Patient tilt is optionally combined with rotation of the patient about a vertical axis, rotation of the entire patient about an axis not overlapped by the patient, and/or dynamic control of angles of incident charged particles directed by beamline magnets of the charged particle therapy system. | 12-03-2015 |
| 20150352113 | TREATMENT OF ASTROCYTES-TUMOR CELLS INHIBITORS OF ENDOTHELIN RECEPTORS - The disclosure relates to an endothelin receptor antagonist for use in the prevention or treatment of brain metastases in combination with a cytotoxic chemotherapy agent, radiotherapy or both. The endothelin receptor antagonist may for example be bosentan, macitentan or a mixture of bosentan and macitentan. | 12-10-2015 |
| 20150352372 | PARTICLE THERAPY SYSTEM - The present invention provides a particle therapy system including an irradiation compensating device made up of an energy absorber, a first collimator, and a second collimator for use in a short-range region. The irradiation compensating device is characterized by a mechanism for attaching and detaching the first energy absorber, first collimator, and second collimator. The first collimator is located upstream where the beam diameter is small with a view to suppressing the width of the compensating device, thereby contributing to making the compensating device small and lightweight. The second collimator is located downstream to improve penumbrae. | 12-10-2015 |
| 20150352373 | AN APPARATUS TO DELIVER CONFORMAL RADIOTHERAPY USING EXTERNAL BEAM COBALT 60 - An apparatus to deliver conformal radiotherapy using external beam Cobalt 60 source is disclosed. The apparatus comprises an enclosed circular gantry placed above the bearings along with an integrated in house X-ray unit with the X-ray detector, source head and beam stopper. The X-ray unit along with the X-ray detector of the enclosed circular gantry are aligned to the radiation beam plane such that 3-D image of the tumour can be constructed using a cone beam computed tomography (CBCT) and radiation treatment is delivered by beam limiting device, without moving the patient from one patients treatment couch to other thus reducing the inconvenience to the patient achieving high tumour positioning accuracy and for alignment of X-ray and radiation beams. | 12-10-2015 |
| 20150352374 | FAST AND ACCURATE PROTON THERAPY DOSE CALCULATIONS - Simulating particle beam interactions includes identifying a set of n functions F | 12-10-2015 |
| 20150352375 | RADIOTHERAPY APPARATUS - A radiotherapy apparatus includes a source of radiation, a patient support for locating a patient in the field of the source of radiation, a position detector for determining a position of a patient relative to the radiotherapy apparatus, a comparator for comparing the output of the position detector with a predetermined position, and a feedback system for informing the patient of the output of the comparator. | 12-10-2015 |
| 20150352377 | PARTICLE BEAM THERAPY SYSTEM - Plural equipment control devices of a particle beam therapy system comprise an equipment operation parameter calculation unit calculating equipment operation parameters based on data given by equipment data servers individually and an equipment operation verification data generation unit generating equipment operation parameter verification data for verifying soundness of the equipment operation parameters, an equipment data server comprises an equipment operation parameter integrating calculation unit calculating so as to obtain equipment operation parameters of each equipment, an equipment operation parameter verification data integrating generation unit generating an equipment operation parameter verification data of each equipment for verifying soundness of equipment operation parameters of each equipment, and a verification data comparison unit comparing equipment operation parameter verification data of each equipment which is received from plural equipment control devices with equipment operation parameter verification data of each equipment which is generated by the operation parameter verification data integrating calculation unit. | 12-10-2015 |
| 20150352378 | METHOD FOR TREATING SKIN CANCER USING RADIATION THERAPY - The described invention provides methods for irradiating skin cancer cells, such as melanoma cells, at a high radiation rate (e.g., of 2,400 mu/min) and a modest total dose (e.g., of 0.5 Gy) to treat skin cancer or induce apoptosis in skin cancer cells. The radiation may be administered in a plurality of treatments and used in conjunction with chemotherapy. | 12-10-2015 |
| 20150359754 | METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL - The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection. | 12-17-2015 |
| 20150360053 | PARTICLE BEAM IRRADIATION SYSTEM AND PARTICLE BEAM THERAPY SYSTEM PROVIDED THEREWITH - A particle beam irradiation system comprising a scanning electromagnet for a particle beam to scan an irradiation objective, a scanning information storage section for storing scanning position information regarding a plurality of scanning positions in a case where a particle beam scans an irradiation objective and scanning order information which is order for scanning a plurality of scanning positions, and a scanning electromagnet control section for controlling a scanning electromagnet based on scanning position information and scanning order information which is stored in the scanning information storage section, wherein the scanning position information which is stored in the scanning information storage section includes a part whose scanning position information is same as the scanning position information of adjacent order. | 12-17-2015 |
| 20150360054 | METHOD AND APPARATUS FOR CONTROLLING AND MONITORING POSITION OF RADIATION TREATMENT SYSTEM - Disclosed are a method and apparatus for controlling and monitoring a position of a radiation treatment system, the method of controlling the position of the radiation treatment system, including: capturing a first image of a patient on a first axis and a second axis using a first camera and capturing a second image of the patient on the second axis and a third axis using a second camera; acquiring a third image of the patient captured using the first camera and a fourth image of the patient captured using the second camera during previous radiation treatment; and controlling a position of the patient to compensate for the calculated first position change based on the first image and the third image and the calculated second position change based on the second image and the fourth image. | 12-17-2015 |
| 20150360055 | CONTROLLING A PROCESS OF MONITORING THE POSITION OF A PATIENT DURING RADIATION TREATMENT - The invention is directed to a method for controlling a process of monitoring the position of at least a part of a patient's body ( | 12-17-2015 |
| 20150360056 | Visualizing Radiation Therapy Beam in Real-Time in the context of Patient's Anatomy - A method of real-time radiotherapy beam visualization is provided that includes disposing a free-form flexible scintillating sheet on a subject of interest, irradiating the subject of interest with a source of ionizing radiation, where the free-forming flexible scintillating sheet emits light when irradiated by the therapeutic photon beam, collecting the emitted light and collecting ambient light reflected from the subject of interest and surrounding objects using a camera, where the collected light is converted to image data by the camera, where the image data is communicated to an appropriately programmed computer, and processing the image data to determine beam characteristics and the characteristics of the subject of interest, using the appropriately programmed computer, where the beam characteristics and the characteristics of the subject of interest are displayed in real-time to a machine operator enabling real-time verification of treatment delivery. | 12-17-2015 |
| 20150360057 | MULTI-FIELD CANCER THERAPY APPARATUS AND METHOD OF USE THEREOF - A multi-field cancer therapy apparatus and method of use thereof is described increasing dimensionality of incident tumor treatment angles while minimizing distance between a final beamline focusing magnet and the patient. Increased dimensionality of incident tumor treatment angles is achieved through coordinated use of one or more of: a rotatable targeting magnet; a first patient rotation platform rotating the patient around, without intersecting, a vertical axis; a second patient rotation platform rotating a body part through a movable vertical axis; and patient tilt. The increased charged particle incident angle dimensionality distributes Bragg peak tail energy about the tumor. Dynamic energy and/or intensity control of the charged particle beam as a function of efficiency of beam delivery based on tumor shape further reduces Bragg peak tail energy delivered to healthy tissue about the tumor. | 12-17-2015 |
| 20150366964 | ANTI-TUMOR T CELL IMMUNITY INDUCED BY HIGH DOSE RADIATION - Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual. | 12-24-2015 |
| 20150367143 | THERAPY PLANNING DEVICE, SYSTEM FOR PLANNED THERAPY, METHOD FOR MAKING THERAPY PLAN, AND PROGRAM - A therapy planning device includes: a condition acquiring unit configured to acquire therapy conditions including a position of an affected area, a necessary dose for the affected area, and a threshold dose for an area other than the affected area; a first planning unit configured to plan a first irradiation of irradiating a first irradiation field including the entire affected area to radiation; and a second planning unit configured to make a therapy plan satisfying the therapy conditions in combination of the first irradiation planned by the first planning unit and irradiation of an irradiation field including only part of the affected area. | 12-24-2015 |
| 20150367145 | SYSTEM AND METHOD FOR AUTOMATIC TREATMENT PLANNING - The present disclosure relates to systems, methods, and computer-readable storage media for radiotherapy. Embodiments of the present disclosure may receive a plurality of training data and determine one or more predictive models based on the training data. The one or more predictive models may be determined based on at least one of a conditional probability density associated with a selected output characteristic given one or more selected input variables or a joint probability density. Embodiments of the present disclosure may also receive patient specific testing data. In addition, embodiments of the present disclosure may predict a probability density associated with a characteristic output based on the one or more predictive models and the patient specific testing data. Moreover, embodiments of the present disclosure may generate a new treatment plan based on the prediction and may use the new treatment plan to validate a previous treatment plan. | 12-24-2015 |
| 20150367146 | Determining Soft-Tissue Shift Taking Into Account Bony Shift - A medical data processing method for determining a change in the position of a soft tissue body part of a patient's body, the data processing method being constituted to be executed by a computer and comprising the following steps: a) acquiring (S | 12-24-2015 |
| 20150374324 | PARTICLE THERAPY SYSTEM - There is provided a particle therapy system including: a particle beam generator for generating a particle beam; an irradiation nozzle arranged in a treatment room and irradiating a target with the particle beam; a particle beam transport system | 12-31-2015 |
| 20150374443 | CRANIAL ALIGNMENT DEVICE FOR USE IN INTRACRANIAL STEREOTACTIC SURGERY - A cranial alignment device for use in intracranial stereotactic radiotherapy includes a nosepiece that is custom shaped to mate with the dorsum and alae of the patient's nose. | 12-31-2015 |
| 20150374818 | INORGANIC NANOPARTICLES COMPOSITIONS IN COMBINATION WITH IONIZING RADIATIONS FOR TREATING CANCER - The present application relates to activable inorganic nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cancerous cells, tissues or organs. It more particularly relates to nanoparticles which can generate a surprisingly efficient therapeutic effect, when concentrated inside the tumor and exposed to ionizing radiations. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses. | 12-31-2015 |
| 20150375009 | Treating and preventing virus infections in animals - A method for preventing disease in an animal by exposing the animal to one or more doses of geothermal energy wherein the total dose of geothermal energy is in the range of from 10 to 2000 mJ/kg. In addition, a method for treating disease in an animal by exposing the animal to one or more doses of geothermal energy wherein the total dose of geothermal energy is in the range of from 10 to 2000 mJ/kg. | 12-31-2015 |
| 20150376272 | INHIBITION OF ANGIOGENESIS IN REFRACTORY TUMORS - The present invention relates generally to the inhibition of tumor angiogenesis. In particular, the invention concerns the prevention or treatment of tumor angiogenesis and the suppression of tumor growth in tumors refractory to an anti-vascular endothelial growth factor (VEGF) treatment, using IL-17 antagonists, such as anti-IL-17 antibodies and other antagonists. | 12-31-2015 |
| 20160000744 | Methods of Inhibiting IGF-1R Activation or Downtream Signalling Thereof to Reduce Radiation-Induced Cellular Senescence - Accelerated senescence has been shown to occur as a primary response to cellular stresses including DNA damaging agents (e.g., ionizing radiation) and is widely believed to be caused by continuous proliferative signaling in the presence of cell cycle arrest. The present disclosure provides a method of reducing cellular senescence in non-cancerous cells following exposure to ionizing radiation. The method comprises administering to a subject before, after, or concurrently with exposure to ionizing radiation an effective amount of a compound that inhibits activation of an insulin-like growth factor receptor (IGF-1R) or a compound that inhibits a protein involved in an IGF-1R induced signaling cascade. Also provided is a composition for use in reducing cellular senescence in non-cancerous cells following exposure to ionizing radiation, the composition comprising a compound that inhibits activation of an insulin-like growth factor receptor (IGF-1R) or a compound that inhibits a protein involved in an IGF-1R induced signaling cascade. | 01-07-2016 |
| 20160000772 | Methods of Using C-Met Modulators - Methods of treating cancer by administering a compound of Formula I, | 01-07-2016 |
| 20160001094 | SKIN PATCH DOSIMETER - A skin patch sensor having a groove therein to receive a sensor without leaving any air pockets is described. The skin patch sensor also has a water or tissue equivalent material and/or, in some embodiments, a moldable water equivalent material. | 01-07-2016 |
| 20160008497 | Method for Treating Lung Carcinoma | 01-14-2016 |
| 20160008630 | APPARATUS FOR DETERMINING A NUMBER OF BEAMS IN IMRT | 01-14-2016 |
| 20160008631 | PARTICLE THERAPY DEVICE AND METHOD FOR SETTING DOSE CALIBRATION FACTOR | 01-14-2016 |
| 20160016007 | METHOD FOR IMPROVED SURFACE TRACKING-BASED MOTION MANAGEMENT AND DYNAMIC PLANNING IN ADAPTIVE EXTERNAL BEAM RADIATION THERAPY - A therapy system and method treats an internal target of a patient ( | 01-21-2016 |
| 20160016008 | Radiosurgical Planning and Treatment - Multiple tumors are grouped into multiple treatment groups. Tumors in different treatment groups are treated by a radiosurgery in different treatment sessions than the tumors in the same treatment groups. The tumors can be grouped so as to decrease the biologically effective dose received by normal tissue in the treatment area. The radiosurgical planning system can divide the tumors into groups based on their location relative to each other and the radiation the tumors will be treated with and create a plan for treating the tumors according to the treatment groups. | 01-21-2016 |
| 20160016010 | PROTON SCATTERING ANALYSIS SYSTEM - Disclosed are systems and methods for characterizing interactions or proton beams in tissues. In certain embodiments, charged particles emitted during passage of protons, such as those used for therapeutic and/or imaging purposes, can be detected at relatively large angles. In situations where beam intensity is relatively low, such as in certain imaging applications, characterization of the proton beam with charged particles can provide sufficient statistics for meaningful results while avoiding the beam itself. In situations where beam intensity is relatively high, such as in certain therapeutic applications, characterization of the proton beam with scattered primary protons and secondary protons can provide information such as differences in densities encountered by the beam as it traverses the tissue and dose deposited along the beam path. In certain situations, such beam characterizations can facilitate more accurate planning and monitoring of proton-based therapy. | 01-21-2016 |
| 20160016011 | PARTICLE BEAM IRRADIATION CHAMBER - A particle beam irradiation chamber in which a passage having a first opening part at a side of an inner wall and a second opening part at a side of an outer wall is provided and which has an isocenter inside the chamber, wherein a first line segment which connects the center of the first opening part and the center of the second opening part passes inside the passage, an angle, which is formed by a second segment, which connects the center of the first opening part and the isocenter and the first line segment, is smaller than 180 degrees, and a width of the passage is narrower than a width of opening of the first opening part. | 01-21-2016 |
| 20160022881 | BIORESORBABLE DRUG DELIVERY MATRICES BASED ON CROSS-LINKED POLYSACCHARIDES, DOSAGE FORMS DESIGNED FOR DELAYED/CONTROLLED RELEASE - Bioactive agents are embedded in a cross-linked dextran and coated with a bioresorbable polymer. When implanted in a mammal, the coated cross-linked dextran composition produces controlled release of the embedded bioactive agent. | 01-28-2016 |
| 20160023018 | SYSTEM AND METHOD FOR IRRADIATION THERAPY USING VOXEL BASED FUNCTIONAL MEASUREMENTS OF ORGANS AT RISK - A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure fj at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure fj for that voxel summed over all voxels. | 01-28-2016 |
| 20160023019 | IMAGING BASED CALIBRATION SYSTEMS, DEVICES, AND METHODS - Systems, devices, and methods for imaging-based calibration of radiation treatment couch position compensations. | 01-28-2016 |
| 20160024594 | BIOMARKERS FOR RADIATION TREATMENT - The methods described herein allow for the classification of patients into groups for receiving optimized radiation treatment based on patient specific biomarker signature. The biomarker signature includes markers that have been shown to correlate with TGF-β expression and to be associated with tumor aggressiveness, radioresistance and poor prognosis. The markers play a key role in the epithelial-mesenchymal transition. The methods described herein provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining TGF-β inhibitors with ionizing radiation to treat cancer patients. | 01-28-2016 |
| 20160030767 | AUDIO-VISUAL SUMMARIZATION SYSTEM FOR RT PLAN EVALUATION - A method for reviewing a treatment plan ( | 02-04-2016 |
| 20160030769 | METHOD AND DEVICE FOR FAST RASTER BEAM SCANNING IN INTENSITY-MODULATED ION BEAM THERAPY - A method and device are designed to deliver intensity-modulated ion beam therapy radiation doses closely conforming to tumors of arbitrary shape, via a series of two-dimensional (2-D) continuous raster scans of a pencil beam, wherein each scan takes no more than about 100 milliseconds to complete. The device includes a fast scanning nozzle for the exit of an ion beam delivery gantry. The fast scanning nozzle has a fast combined-function X-Y steering magnet, and is coupled to a rastering control system capable of adjusting the length of each scan line, continuously varying the beam intensity along each scan line, and executing multiple rescans of a tumor depth layer within a single patient breathing cycle. An in-beam absolute dose and dose profile monitoring system is capable of millimeter-scale position resolution and millisecond-scale feedback to the control system to ensure the safety and efficacy of the treatment implementation. | 02-04-2016 |
| 20160030770 | RETROSPECTIVE CALCULATION OF RADIATION DOSE AND IMPROVED THERAPY PLANNING - A combined magnetic resonance (MR) and radiation therapy system includes a bore-type magnet with a magnet radiation translucent region which allows radiation beams to travel radially through the magnet and a split-type gradient coil includes a gradient coil radiation translucent region aligned to the magnet radiation translucent region. A radiation source, disposed laterally to the magnet, administers a radiation dose through the magnet and gradient coil radiation translucent regions to an examination region. A dosage unit determines the actual radiation dose delivered to each voxel of a target volume and at least one non-target volume based on a pre-treatment, intra-treatment, and/or post-treatment image representation of the target volume and the at least one non-target volume. A planning processor updates at least one remaining radiation dose of a radiation therapy plan based on the determined actual radiation dose. | 02-04-2016 |
| 20160031909 | PORPHYRAZINE OPTICAL AND DUAL OPTICAL/ MR CONTRAST AND THERAPEUTIC AGENTS - Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation. | 02-04-2016 |
| 20160038766 | SHIELDED STRUCTURE FOR RADIATION TREATMENT EQUIPMENT AND METHOD OF ASEMBLY - A modularized approach for rapidly and cost effectively assembling a structure suitable for housing radiation emitting equipment is disclosed. The modules include reinforced walls to contain radiation shielding fill material. The modules are transported empty and then filled on site with the fill material to form a radiation shielding barrier around radiation emitting equipment. | 02-11-2016 |
| 20160045509 | Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation - This invention is in the area of improved compounds and methods for transiently protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC), from the damage associated with ionizing radiation (IR) exposure using selective radioprotectants. | 02-18-2016 |
| 20160045768 | Real-time, on-line and offline treatment dose tracking and feedback process for volumetric image guided adaptive radiotherapy - A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan. | 02-18-2016 |
| 20160045769 | ACCESSORY HOLDER FOR PARTICLE BEAM APPARATUS - The present disclosure relates to an accessory holder attachable to or integrated in the nozzle of an apparatus for particle beam irradiation treatment. The accessory may be an aperture piece, a range shifter or any other element that can be placed in the beam path between the outer end of the nozzle and the irradiated target. The accessory holder may be equipped with first displacement means for moving the accessory away from or towards the nozzle, thereby moving the accessory forwards and backwards in the direction of the beam and second displacement means for moving the accessory into or out of the beam path. Measurements or treatment steps may be performed with and without the accessory in the beam path, without interrupting the treatment. | 02-18-2016 |
| 20160051672 | METHODS OF TREATMENT WITH ANTAGONISTS AGAINST PD-1 AND PD-L1 IN COMBINATION WITH RADIATION THERAPY - This application provides a method of treating cancer in a patient comprising administering at least one dose of radiation therapy and at least one PD-1 and/or PD-L1 antagonist, wherein at least one PD-1 and/or PD-L1 antagonist is administered on the same day as a dose of radiation therapy or up to and including 4 days later. | 02-25-2016 |
| 20160051840 | METHOD AND SYSTEM FOR ROBUST RADIOTHERAPY TREATMENT PLANNING - A method for generating a robust radiotherapy treatment plan for a treatment volume of a subject. An adjusted voxel-specific dose objective is determined by “smearing” an initial voxel-specific dose objective a specified distance in at least one direction. A treatment plan based on such adjusted dose objective will be more robust with respect to setup uncertainties and organ movements. Smearing of the dose objective corresponds to adjusting the dose objective dose value of a voxel in accordance with dose objective dose values of voxels within the specified distance. | 02-25-2016 |
| 20160051841 | Image-Guided Radiotherapy For Internal Tumor Boost - A method of image-guided radiotherapy for treatment of a radio-resistant or radio-sensitive tumor. A three-dimensional visualized tumor image is obtained and the boundary of the tumor is identified. A boosted radiation dose of treatment is designated and applied to a boost region within the tumor boundary. A predetermined prescribed radiation dose is simultaneously applied with the boosted radiation dose within the tumor boundary and in a planning target volume region, which is outside of the tumor boundary. The boosted radiation dose outside of the boost region decreases at a boost dose decreasing rate such that the boosted radiation dose is equal to the predetermined prescribed radiation dose at the tumor boundary. | 02-25-2016 |
| 20160051842 | METHOD AND APPARATUS FOR PLANNING OR CONTROLLING A RADIATION TREATMENT - A method for generating planning data or control data for a radiation treatment, comprising the following steps: acquiring segmented data of an object which contains a treatment volume and a non-treatment volume; modelling at least some or all of the volume or surface of the treatment volume as a source of light or rays exhibiting a predefined or constant initial intensity; modelling the non-treatment volume as comprising volumetric elements or voxels which each exhibit an individually assigned feature or attenuation or transparency value (t | 02-25-2016 |
| 20160051843 | HEART TISSUE SURFACE CONTOUR-BASED RADIOSURGICAL TREATMENT PLANNING - A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan. | 02-25-2016 |
| 20160051844 | PARTICLE BEAM IRRADIATION ROOM AND PARTICLE BEAM THERAPY SYSTEM - The particle beam irradiation room of the invention includes: an irradiation execution room in which a patient table having a detachable-attachable top board and an actuation device for actuating the top board is mounted, and that is surrounded by a shielding wall; a passage formed in the shielding wall on its side where a pre-room for positioning the patient relative to the top board is located, in a form that allows the patient positioned relative to the top board to pass straight to the irradiation execution room by a transport apparatus; and a shielding door at the irradiation-room entrance located on a side of the passage toward the pre-room, for shielding against a leakage radiation at the radiation of the particle beam so that the leakage radiation is kept at a management value or less. | 02-25-2016 |
| 20160053323 | GENOSPECIFIC RADIOSENSITIZATION - A method of treating a subject who has been diagnosed with cancer is described. The method includes characterizing the radiation-susceptibility of the subject by detecting a mutation in an NRF2 pathway protein in suitable sample obtained from the subject and treating the subject with radiation therapy if the subject is characterized as being radiation-susceptible, or treating the subject with radiation therapy and a radiosensitizing agent if the subject is characterized as being radioresistant. A method of determining if a subject has a history of tobacco smoking is also described that includes analyzing an NRF2 pathway protein to determine if a mutation is present in suitable sample obtained from the subject and characterizing the subject as having a history of tobacco smoking if a genetic fingerprint consistent with tobacco exposure is identified. | 02-25-2016 |
| 20160058733 | CDC7 KINASE INHIBITORS AND USES THEREOF - The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): | 03-03-2016 |
| 20160058993 | Methods for Cancer Treatment - Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc. | 03-03-2016 |
| 20160059037 | SYSTEM AND METHOD FOR AUTOMATED RADIATION TREATMENT PLANNING USING PHYSICAL OBJECTIVES - Systems and methods for generating a radiation treatment plan using inverse planning objectives that are automatically determined based on patient data and the physical capabilities of the radiation treatment system are provided. In particular, the planned target volumes and organ-at-risk (OAR) volumes are used to automatically partition the OAR volumes into one or more avoidance volumes, for which particular inverse planning objectives are established based on the physical capabilities of the treatment system. As an example, an inverse planning objective may include establishing a particular dose gradient over one or more avoidance volumes. Because such inverse planning objectives are based on conditions and constraints of the treatment system physics, rather than a desired percentage of the prescribed dose, they may be referred to as “physical objectives.” | 03-03-2016 |
| 20160059038 | DOSE RATE MODULATED STEREOTACTIC RADIO SURGERY - The present disclosure relates to methods and systems for radiotherapy. Embodiments of the present disclosure may receive a medical image including images of a target and an organ at risk (OAR). Some embodiments may also receive a target dose and a constraint on an OAR dose. Some embodiments may also generate a dose application plan based on the target dose and the constraint. Generation of the dose application plan may include determining a placement of an arc along which radiation is to be applied based on the target dose and a location of the target; dividing the arc into a plurality of segments; determining a dose rate associated with each segment; calculating a predicted OAR dose based on the determined dose rate; and comparing the predicted OAR dose with the constraint on the OAR dose to determine whether the predicted OAR dose satisfies the constraint on the OAR dose. | 03-03-2016 |
| 20160059039 | SYSTEM AND METHOD FOR ROBUST INTENSITY-MODULATED PROTON THERAPY PLANNING - The present invention provides a system and method for generating intensity modulated proton therapy plans. The method includes receiving a representation of a subject that includes information related to target and non-target volumes of interest, and computing, using the representation and a proton beam configuration that describes a number of beamlets and their respective arrangement, a dose distribution for each one of a plurality of uncertainty scenarios. The method also includes computing a robustness index for respective locations in the target volumes of interest using the dose distributions, and optimizing an objective function to determine a set of intensity weights for each beamlet in the proton beam configuration, wherein the objective function is based at least in part on deviations of the robustness indices from a prescribed robustness index. The method further includes generating a treatment plan using the determined intensity weights. | 03-03-2016 |
| 20160059042 | METHOD AND DEVICE FOR COMPUTING IN A VOLUME PHYSICAL AND/OR RADIOBIOLOGICAL QUANTITIES INDUCED BY AN ION BEAM - The method of the invention comprises the steps of: providing a reference ion beamlet; determining in a phantom ( | 03-03-2016 |
| 20160067260 | Compositions and Methods for Treating Proliferation Disorders - The present invention relates to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-(3-morpholinophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or N-(1-(3-(3-(4-(1-aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)piperidin-4-yl)-N-methylacetamide. The methods of the present invention can also relate to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing the above compounds in combination with ((R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine). | 03-10-2016 |
| 20160067322 | METHOD OF TREATING LUNG CANCER BY VACCINATION WITH MUC-1 LIPOPEPTIDE - The invention is directed to the treatment of lung cancer, preferably non-small cell lung cancer (NSCLC) by means of a combination therapy comprising concurrent chemo-radiotherapy followed by vaccination with a muc-1 lipopetide. The therapy elicits prolonged survival rates compared to a respective therapy including sequential chemo-radiotherapy. | 03-10-2016 |
| 20160067522 | METHOD FOR SKIN IMPROVEMENT USING LOW-DOSE RADIATION - The present disclosure relates to a method for skin improvement using low-dose radiation, and the low-dose radiation can exhibit excellent effects of improving skin wrinkles, improving skin barriers, improving skin thickness, improving skin elasticity, and improving skin moisture through the mechanisms of promoting the growth of normal human dermal fibroblasts, increasing the collagen synthesis within the normal human dermal fibroblast, or reducing the metalloproteinase synthesis within the normal human dermal fibroblasts, thus being effectively used for skin improvement. Additionally, the low-dose radiation of the present disclosure can exhibit excellent hair growth-promoting effect through the mechanisms of promoting the growth of human dermal papilla cells or activating hair follicle cells, thus being useful for the improvement of promoting hair growth. | 03-10-2016 |
| 20160067524 | SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE - A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent. | 03-10-2016 |
| 20160067525 | PATIENT POSITIONING SYSTEM - An example treatment system includes: a treatment couch for holding a patient; fiducials associated with the patient; an imaging system to capture an image of the fiducials and of an irradiation target while the patient is on the treatment couch, where the image is captured in a treatment room where treatment is to be performed; a mechanism to move the treatment couch; and a computer system programmed to align locations of the fiducials to the fiducials in the image, and to determine a location of the irradiation target relative to a treatment system based on locations of the fiducials and based on the image. The movement of the treatment couch into a treatment position in the treatment room may be based on the location of the irradiation target. | 03-10-2016 |
| 20160074512 | PROTON INDUCED BORON CAPTURE THERAPY - The present disclosure recites a method of treating biological tissues. The method includes using a proton beam includes irradiating a proton beam to a biological tissue containing a reactant. The reactant includes a first composite and a second composite. The first composite reacts with at least one proton from the proton beam and then releases at least one neutron inside the biological tissue. The second composite reacts with the at least one said neutron to release at least one α particle or γ rays, and said α particle or said γ rays to react with the biological tissue. | 03-17-2016 |
| 20160074673 | PORTAL IMAGING DURING RADIOTHERAPY - A radiotherapy apparatus comprises a source for producing a beam of ionising radiation along an axis, the beam covering a maximum aperture of the source, a collimator for collimating the beam to produce a collimated beam covering a sub-part of the maximum aperture, a patient support positioned in the path of the beam, a rotatable gantry, on which the source is mounted, for rotating the source around the patient support thereby to deliver the beam from a range of directions, an imaging device located opposite the source and with the patient support between the source and the imaging device, and mounted on the gantry via a drive member allowing translational motion of the imaging device in at least one direction perpendicular to the axis, and a control unit adapted to control the drive member to move the imaging device within the maximum aperture and maintain coincidence between the imaging device and the sub-part of the maximum aperture. Accordingly, the EPID can be moved during the treatment in order to maintain the collimated field of the radiation beam within the bounds of the EPID. This ensures that the image is valid and prevents damage to the EPID as a result of exposure of more sensitive (or less shielded) parts to the beam. | 03-17-2016 |
| 20160074675 | SYSTEM DESIGN AND METHOD FOR VERIFYING 3D DOSIMETRIC IMAGING OF CHARGED PARTICLES IN MEDIA - A method of verifying therapeutic proton beam delivery accuracy by ultrasound tomographic imaging to map three dimensional (3D) proton dose through the detection of ionizing radiation induced thermo-acoustic signal from the proton beam. | 03-17-2016 |
| 20160074676 | ACCELERATED PARTICLE IRRADIATION EQUIPMENT - Accelerated particle irradiation equipment is installed in a building having a multi-story structure. The accelerated particle irradiation equipment includes a particle accelerator and an irradiation device. The particle accelerator generates accelerated particles. The irradiation device performs irradiation of the accelerated particles generated by the particle accelerator, and is installed on at least one of the floor above and the floor below the floor on which the particle accelerator is installed. | 03-17-2016 |
| 20160082179 | SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION - Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed. | 03-24-2016 |
| 20160082180 | SYSTEMS AND METHODS FOR REGULATING ORGAN AND/OR TUMOR GROWTH RATES, FUNCTION, AND/OR DEVELOPMENT - A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and/or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and/or reverse the growth of a prostate gland or a prostate tumor. | 03-24-2016 |
| 20160082283 | METHOD FOR PRODUCING DATA REPRESENTING RADIOTHERAPY TREATMENT CONSTRAINTS, DEVICES AND CORRESPONDING PROGRAM - A method is provided for producing data representing radiotherapy treatment constraints associated with a patient to be treated. The method includes: a phase of mapping at least one current atlas of a set of atlases according to at least one datum representing a patient to be treated, providing a map of probability regions at risk; and a phase of generating at least one datum representing a constraint to be applied to a treatment for the patient according to the probability of regions at risk. | 03-24-2016 |
| 20160082284 | PARTICLE BEAM TREATMENT SYSTEM, PARTICLE BEAM TREATMENT METHOD, AND COMPUTER PROGRAM PRODUCT - According to an embodiment, a particle beam treatment system includes a storage, an estimator, a target value generator, and a particle beam treatment device. The storage stores therein a respiratory movement model obtained by synchronizing amount of displacement of an affected area of a subject with a signal related to respiration of the subject and performing modeling. The estimator estimates, based on the measured signal related to respiration and the respiratory movement model, amount of displacement of the affected area corresponding to the measured signal. The target value generator generates a target value, which is used for performing movement control on a platform on which the subject is lying down, corresponding to the estimated amount of displacement of the affected area. The particle beam treatment device irradiates, with particle beams, the affected area of the subject on the platform subjected to movement control according to the target value. | 03-24-2016 |
| 20160082286 | DIAGNOSTIC OR THERAPEUTIC PROCEDURE USING IMPLANTABLE TARGETS - An implantable device has a body that is substantially rigid and has an imageable shape. The body is further bioabsorbable and may contain permanent metallic elements to aid in its imaging. When the device is implanted in a resected cavity in soft tissue, it can cause the cavity to conform substantially to a known imageable shape. The implantable device is further imageable due to its attenuation properties being different from those of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined. | 03-24-2016 |
| 20160082287 | DEVICE FOR DETERMINING ILLUMINATION DISTRIBUTIONS FOR IMRT - The invention relates to a device for determining illumination distributions ( | 03-24-2016 |
| 20160082289 | NEW TISSUE COMPENSATOR THICKNESS VISUALIZATION AND MODIFICATION TOOL FOR USE IN RADIATION TREATMENT PLANNING | 03-24-2016 |
| 20160089549 | AN INTERACTIVE DOSE GRADIENT BASED OPTIMIZATION TECHNIQUE TO CONTROL IMRT DELIVERY COMPLEXITY - A method for dose-gradient based optimization of an intensity modulated radiation therapy plan. First, an optimizer ( | 03-31-2016 |
| 20160101296 | RADIATION TREATMENT COLLIMATOR HAVING MULTILAYERED LINKAGE STRUCTURE - The present invention relates to a radiation treatment collimator having a multilayered linkage structure, the collimator providing various shapes of spaces and configuring a radiation area, which transmits radioactive rays, the collimator including: a fixed frame disposed on a plate; multiple pixel board layers fixedly stacked at predetermined intervals on top of each other inside the fixed frame, each pixel board layer being configured in a lattice form and having pixel covers disposed correspondingly to the respective lattices in such a manner as to be open and closed individually; control units disposed on both sides of the fixed frame to individually control the operations of the pixel covers of the pixel board layers; and power source units disposed on the front and rear sides of the fixed frame to supply the pixel board layers with operating power. The collimator is inexpensive and exhibits good treatment results; each pixel can be open/closed separately to form a radioactive ray radiation area; and the collimator is capable of, in real time, converting the shape of the radiation area and adjusting the intensity of the radioactive rays. | 04-14-2016 |
| 20160101297 | PARTICLE BEAM TREATMENT DEVICE AND OPERATION METHOD THEREFOR - When an energy of a particle beam to be emitted from an accelerator is set for every slice group including two or more adjacent slices and an attenuation amount is set for each slice in the slice group, the energy to be emitted from the accelerator is set, for every slice group, higher than an energy corresponding to the slice at a deepest location in that slice group so that a transmissive plate has a predetermined thickness for the slice at the deepest location; and, with respect to a thickness of the transmissive plate to be set for every slice group, the thickness set for the slice group at a deep location is larger than or equal to the thickness set for the slice group at a shallow location, and the thickness set for the slice group at a deepest location is thicker than the thickness set for the slice group at a shallowest location. | 04-14-2016 |
| 20160101298 | PARTICLE BEAM THERAPY SYSTEM - A particle beam transport section comprises a horizontal deflection electromagnet which deflects a particle beam to a direction which is parallel to an accelerator median plane of a circular accelerator, a first perpendicular electromagnet which deflects a particle beam whose travelling direction is deflected by the horizontal deflection electromagnet to a direction which is different from a direction which is parallel to the accelerator median and a second perpendicular electromagnet which deflects the particle beam whose travelling direction is deflected by the first perpendicular deflection to a direction which is parallel to the accelerator median plane, wherein the horizontal deflection electromagnet is provided on a floor which is different from a floor where a particle beam irradiation unit is provided. | 04-14-2016 |
| 20160107001 | PARTICLE BEAM TREATMENT APPARATUS - A particle beam treatment apparatus including a rotating gantry that revolves and displaces an irradiation port for irradiating a radiation treatment room provided inside of the rotating gantry with a charged particle beam comprises: a gantry body portion forming the rotating gantry; a mounted magnet; a displacement meter or an acceleration meter; and a control mechanism. The mounted magnet is connected to the gantry body portion with an intermediation of a magnet support, and guides the charged particle beam to the irradiation port. The displacement meter or the acceleration meter is provided to the mounted magnet, and measures a displacement or an acceleration of the mounted magnet. The control mechanism controls a position of the mounted magnet in a direction so as to reduce the displacement or the acceleration with at least a single degree of freedom measured by the displacement meter or the acceleration meter. | 04-21-2016 |
| 20160114189 | SYSTEM AND METHOD FOR DOSE VERIFICATION AND GAMMA RAY IMAGING IN ION BEAM THERAPY - This disclosure provides systems, methods, and apparatus related to ion beam therapy. In one aspect, a system includes a position sensitive detector and a collimator. The position sensitive detector configured to detect gamma rays generated by an ion beam interacting with a target. The collimator is positioned between the target and the position sensitive detector. The collimator includes a plurality of knife-edge slits, with a first knife-edge slit intersecting with a second knife-edge slit. | 04-28-2016 |
| 20160114192 | IMAGE GUIDANCE FOR RADIATION THERAPY - An adaptive therapy delivery system can receive imaging information including a volumetric image comprising a target such as a tumor or one or more other structures, and can receive imaging information corresponding to one or more imaging slices comprising different portions of the target, such as imaging slices acquired at different times after acquisition of the volumetric image. The system can spatially register information from an earlier-acquired image with a portion of the target included in a later-acquired one of the imaging slices. The system can then determine an updated location of the target indicated by the spatially-registered information. Using the updated location, the system can generate an updated therapy protocol to control delivery of a therapy beam. | 04-28-2016 |
| 20160121137 | RADIOTHERAPY SYSTEM PROVIDED WITH A PROGRAM FOR THE CALCULATION OF THE INTENSITY OF AN ELECTRONS BEAM - A system for radiotherapy is described. The system includes an accelerator of an electron beam, an imaging apparatus, a control unit and a radiation dose sensor connected to the control unit equipped with a program configured to execute the steps: (i) setting a first intensity of the electron beam, according to a predefined image of a target zone, the intensity to be emitted in a first radiation; (ii) operating said accelerator to emit the first radiation being a fraction of the first intensity; (iii) detecting a real intensity during the first radiation by the radiation dose sensor; (iv) acquiring an image of the zone; (v) calculating an intermediate intensity according to the image acquired in the step (iv) and according to the real intensity; and (vi) comparing the first intensity with the intermediate intensity to calculate a final beam intensity for a subsequent second radiation | 05-05-2016 |
| 20160121138 | PHYSICIAN DIRECTED RADIATION TREATMENT PLANNING - The treatment planning engine empowers radiation treatment decision makers, such as a physician, to efficiently identify effective radiation treatment outcomes for a given patient during the contouring stage. Specifically, using the treatment planning engine, the physician may iteratively and in real-time evaluate different treatment outcomes for a patient before selecting an optimal outcome that will guide the delivery of radiation treatment to the patient. By providing real-time information as to potential toxicity and treatment efficacy during the contouring stage, the physician is empowered to make informed decisions at the preliminary contouring stage. | 05-05-2016 |
| 20160121139 | DETECTOR FOR RADIOTHERAPY TREATMENT GUIDANCE AND VERIFICATION - The present invention relates a detector ( | 05-05-2016 |
| 20160129282 | SYSTEMS AND METHODS FOR SPECIFYING TREATMENT CRITERIA AND TREATMENT PARAMETERS FOR PATIENT SPECIFIC RADIATION THERAPY PLANNING - Disclosed herein are systems and methods for specifying treatment criteria and treatment planning parameters for patient specific radiation therapy planning. According to an aspect, a method includes receiving data about a patient, computing geometric characterization of one or more organs at risk proximate to a target volume of a patient or vice versa, and selecting relevant treatment knowledge and experience. The method also includes generating, based on the received data, computed geometric characterization, and available knowledge and experience, a first set of radiation treatment planning parameters that will lead to a high quality plan for the patient. Further, the method includes model-based prediction, based on the data, a second set or more of radiation treatment planning parameters that will lead to alternative achievable plans with different organ sparing objectives for treating the patient. The multiple sets for parameters can be used separately or in conjunction to generate treatment plans. | 05-12-2016 |
| 20160136455 | REAL-TIME QUANTIFICATION OF SKIN BURNS IN EXTERNAL BEAM RADIATION THERAPY - A system for radiation therapy include an imaging device ( | 05-19-2016 |
| 20160136461 | PARTICLE BEAM THERAPY SYSTEM - In the particle beam therapy system, a beam transport system includes a beam-path changer for changing a beam path so as to transport a charged particle beam to any one of the plurality of particle beam irradiation apparatuses; and a treatment management device includes a beam-path controller that generates an emitter control signal for controlling an emitter of an accelerator and a beam-path changer control signal for controlling the beam-path changer so that, with respect to the plurality of particle beam irradiation apparatuses in which treatment is performed at the same treatment period of time, the charged particle beam is transported to each one of the plurality of particle beam irradiation apparatuses for each time period allocated thereto. | 05-19-2016 |
| 20160144198 | SELECTION OF RADIOTHERAPY TREATMENT PLANS - A method for automatic selection of a treatment plan for a patient is provided, where the automatic selection is at least partly based on the plan quality and required resources for each treatment plan in relation to the availability of resources. | 05-26-2016 |
| 20160144201 | INTENSITY-MODULATED PROTON THERAPY - The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites. | 05-26-2016 |
| 20160144202 | BEAM TRANSPORT SYSTEM AND PARTICLE BEAM THERAPY SYSTEM - In a beam transport system, based on a beam temporal-variation related amount that has been calculated by a beam analyzer and that is a beam-position temporal variation amount or a beam diameter at a beam profile monitor, an optical parameter calculator calculates a start-point momentum dispersion function that is a momentum dispersion function (η, η′) of a charged particle beam at a start point in design of the beam transport system that is set on a beam trajectory of the accelerator; and calculates optical parameters using, as an initial condition, the start-point momentum dispersion function and a beginning condition at an irradiation position at the time of detecting profile data. | 05-26-2016 |
| 20160150630 | CHARGED PARTICLE BEAM GENERATOR, CHARGED PARTICLE IRRADIATION SYSTEM, METHOD FOR OPERATING CHARGED PARTICLE BEAM GENERATOR AND METHOD FOR OPERATING CHARGED PARTICLE IRRADIATION SYSTEM - Provided are a charged particle beam generation apparatus, a charged particle beam irradiation apparatus, a particle beam therapy system, and a charged particle beam generation apparatus operating method capable of implementing injection of a charged particle beam into a circular accelerator at an arbitrary timing by setting a normal operation period of a linear accelerator to be larger than a shortest period and securing a stability of the beam. In timing control of controlling injecting, accelerating, emitting, and decelerating processes of a synchrotron | 05-26-2016 |
| 20160151643 | DESIGN FOR SIMPLIFIED REMOVAL OF A BALLOON APPLICATOR | 06-02-2016 |
| 20160151644 | PATH PLANNING AND COLLISION AVOIDANCE FOR MOVEMENT OF INSTRUMENTS IN A RADIATION THERAPY ENVIRONMENT | 06-02-2016 |
| 20160158577 | MEDICAL DEVICE FOR RADIOTHERAPY TREATMENT - The invention relies on a medical device for an intracorporeal location, wherein: it comprises a deformable armature, at least partially made of a shape memory material and having an Ea end and an Eb end, said Ea end being larger than said Eb end, it has an essentially triangular, trapezoidal, ovally or diamond-shaped, the sides of which extending between said Eb end and the corners of said Ea end, said deformable armature includes a middle rip extending from said Ea end to said Eb end and multiple cross elements extending between the middle rip and said sides, wherein said sides are formed by sides braces, it comprises at least one x-ray visible marker fixed at the deformable armature selected from the group consisting of gold, silver, platinum, tantalum, tungsten, niobium, palladium, iridium, it comprises a guide suited for the intracorporeal introduction of said medical device, and an extraction holder of the medical device. The invention also relies on a device for the introduction, by an endoscopic or percutaneous way, of the medical device, and on a method for accurately targeting a target area during radiation treatment through image guidance comprising determining the location of the medical device in real time using at least one method of targeting selected from the group consisting of lasers, visual, infrared, MRUMRS, RF and radiation; and modifying the radiation treatment beam path to adaptively compensate for a change in position of the target area. | 06-09-2016 |
| 20160158578 | BEAM SHAPING ASSEMBLY FOR NEUTRON CAPTURE THERAPY - A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. The reflector leads the neutrons deviated from the main axis back, and a gap channel is arranged between the moderator and the reflector. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation. | 06-09-2016 |
| 20160158579 | BEAM SHAPING ASSEMBLY FOR NEUTRON CAPTURE THERAPY - A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. An outer surface of the moderator includes at least a first tapered section. The reflector leads the neutrons deviated from the main axis back. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation. | 06-09-2016 |
| 20160166854 | THERAPY PLANNING | 06-16-2016 |
| 20160166855 | AUTOMATION OF THERAPY PLANNING | 06-16-2016 |
| 20160166856 | PREDICTIVE COLLISION AVOIDANCE FOR RADIOTHERAPY | 06-16-2016 |
| 20160166857 | Systems and Methods for Composite Dose Quality Assurance with Three-Dimensional Arrays | 06-16-2016 |
| 20160166858 | DEVICE FOR CONTROLLING RADIATION THERAPY DEVICE, RADIATION THERAPY SYSTEM, METHOD FOR CONTROLLING RADIATION THERAPY DEVICE, AND PROGRAM | 06-16-2016 |
| 20160172066 | ENERGY DEGRADER | 06-16-2016 |
| 20160172067 | ROTATING ENERGY DEGRADER | 06-16-2016 |
| 20160175613 | Radiation Therapy Dose Calculation | 06-23-2016 |
| 20160175617 | DYNAMIC BEAM'S EYE VIEW OF PROTON THERAPY IRRADIATION SHOWN IN ANATOMICAL CONTEXT | 06-23-2016 |
| 20160184356 | ARSENIC-BASED TREATMENT OF CANCERS AND INFLAMMATORY DISORDERS - In one embodiment, the invention provides a method of treating a subject who suffers from a cancer (particularly a chemotherapeutic or radiotherapeutic-resistant cancer) or from an inflammatory disorder, the method comprising co-administering to the subject a pharmaceutically-effective amount of: (a) one or more elements or compounds selected from the group consisting of arsenic, an arsenite and arsenic trioxide (ATO); and optionally (b) at least one anticancer agent (preferably a DNA damaging agent); and/or (c) at least one or more Poly(ADP-ribose) polymerase (PARP) inhibitors other than arsenic, an arsenite and arsenic trioxide (ATO). In preferred embodiments, the arsenic for the treatment of cancer, arsenite and ATO serve as radio sensitizers for concomitant radiotherapy as well as PARP inhibitors. Methods for treating inflammatory disease are also disclosed. Related pharmaceutical formulations are also provided. | 06-30-2016 |
| 20160184430 | ANTICANCER PRODRUGS ACTIVATED BY RADIATION OR ULTRAVIOLET TREATMENT AND USE THEREOF - The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid and base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy. | 06-30-2016 |
| 20160184559 | RECTAL BALLOON WITH LOCKING STOPPER - A prostate immobilizing balloon that on full inflation cups the prostate to hold it during treatment is combined with a locking member so that the balloon does not shift during use. Methods of using same are also provided. | 06-30-2016 |
| 20160184607 | LEADING-EDGE CANCER TREATMENT - Kits and methods for the treatment of certain types of cancers, specifically various primary brain cancers. In some embodiments, treatment is directed toward the known areas of cancer cell infiltration and along pathways of likely migration ahead of established areas of cancer cell infiltration. In some embodiments, cancer cells are targeted where they have likely spread, but yet remain undetected. Some embodiments relate to a means of automatically directing radiological analysis along likely pathways of cancer cell migration to precisely determine the extent of detectable cancer spread. In some embodiments, treatments are directed to a predetermined distance along such pathways. | 06-30-2016 |
| 20160184608 | SYSTEMS AND METHODS FOR REAL-TIME TARGET VALIDATION FOR IMAGE-GUIDED RADIATION THERAPY - Systems and methods for real-time target validation during radiation treatment therapy based on real-time target displacement and radiation dosimetry measurements. | 06-30-2016 |
| 20160184609 | System For Delivering Conformal Radiation Therapy While Simultaneously Imaging Soft Tissue - Devices and processes for performing magnetic resonance imaging of the anatomy of a patient during radiation therapy to measure and control the radiation dose delivered to the patient. | 06-30-2016 |
| 20160184610 | Tumor Tracking System and Method for Radiotherapy - A system and method for tracking a tumor includes a regression module for selecting, using a motion signal and a regression function, a feature signal from a set of feature signals, each feature signal in the set of feature signals represents a medical image of the body of the patient, wherein the motion signal represents a motion of a surface of a skin of the patient caused by the respiration, and wherein the regression function is trained based on a set of observations of the motion signal synchronized with the set of feature signals; and a registration module for determining the location of the target object using the feature signal and a registration function, wherein the registration function registers each feature signal to a breath-hold location of the target object identified. | 06-30-2016 |
| 20160193481 | METHODS AND SYSTEMS FOR RF POWER GENERATION AND DISTRIBUTION TO FACILITATE RAPID RADIATION THERAPIES | 07-07-2016 |
| 20160193482 | ARRAYS OF ACCELERATING STRUCTURES AND RAPID IMAGING FOR FACILITATING RAPID RADIATION THERAPIES | 07-07-2016 |
| 20160193483 | SYSTEMS AND METHODS FOR USE IN EMISSION GUIDED RADIATION THERAPY | 07-07-2016 |
| 20160199490 | TRANS CAROTENOIDS, THEIR SYNTHESIS, FORMULATION AND USES | 07-14-2016 |
| 20160199667 | METHOD AND SYSTEM FOR DYNAMICALLY-TRIMMED SPOT SCANNING FOR ION THERAPY | 07-14-2016 |
| 20160199669 | TARGETING IMPLANT FOR EXTERNAL BEAM RADIATION | 07-14-2016 |
| 20160199670 | CHARGED PARTICLE TRANSLATION SLIDE CONTROL APPARATUS AND METHOD OF USE THEREOF | 07-14-2016 |
| 20160199671 | GANTRY COMPRISING BEAM ANALYSER FOR USE IN PARTICLE THERAPY | 07-14-2016 |
| 20160250018 | METHOD FOR UTILIZING AN IMPLANT IN A BODY OF A PATIENT | 09-01-2016 |
| 20160250330 | SCINTILLATOR NANOCRYSTAL-CONTAINING COMPOSITIONS AND METHODS FOR THEIR USE | 09-01-2016 |
| 20160250501 | CHARGED PARTICLE TREATMENT, RAPID PATIENT POSITIONING APPARATUS AND METHOD OF USE THEREOF | 09-01-2016 |
| 20160250503 | TREATMENT DELIVERY CONTROL SYSTEM AND METHOD OF OPERATION THEREOF | 09-01-2016 |
| 20160375268 | PROSPECTIVE ADAPTIVE RADIATION THERAPY PLANNING - A therapy planner ( | 12-29-2016 |
| 20160375269 | DUAL ROTATION CHARGED PARTICLE IMAGING / TREATMENT APPARATUS AND METHOD OF USE THEREOF - The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as: (1) using a rotatable gantry support to support and rotate a section of a positively charged particle beam transport line about a rotation axis and a tumor of a patient; (2) using a rotatable and optionally extendable secondary support to support, circumferentially position, and laterally position a primary and optional secondary imaging system about the tumor; (3) image the tumor using the primary and optional secondary imaging system as a function of rotation and/or translation of the secondary support; and (4) treat, optionally concurrently with imaging, the tumor using the positively charged particles as a function of circumferential position of the section of the charged particle beam about the tumor. | 12-29-2016 |
| 20170232274 | SUPERVISED 4-D DOSE MAP DEFORMATION FOR ADAPTIVE RADIOTHERAPY PLANNING | 08-17-2017 |
| 20170236631 | PARTICLE BEAM IRRADIATION EQUIPMENT | 08-17-2017 |
| 20180021594 | VOLUMETRIC MODULATED ARC THERAPY (VMAT) WITH NON-COPLANAR TRAJECTORIES | 01-25-2018 |
| 20180021595 | SYSTEMS AND METHODS FOR GENERATING BEAM-SPECIFIC PLANNING TARGET VOLUME DESIGN OUTPUTS | 01-25-2018 |
| 20180021596 | MULTILEAF COLLIMATOR AND RADIATION TREATMENT DEVICE | 01-25-2018 |
| 20180021597 | X-Ray Patient Position Monitoring | 01-25-2018 |
| 20190143085 | ENDORECTAL BALLOON WITH GAS LUMEN AND STOPPER | 05-16-2019 |
| 20190143141 | MEDICAL IMAGE-BASED RADIATION SHIELDING DEVICE AND METHOD THEREOF | 05-16-2019 |
| 20190143144 | INCREASED BEAM OUTPUT AND DYNAMIC FIELD SHAPING FOR RADIOTHERAPY SYSTEM | 05-16-2019 |
| 20190143145 | SYSTEMS AND METHODS FOR PATIENT MONITORING FOR RADIOTHERAPY | 05-16-2019 |
| 20190143146 | RADIATION IRRADIATING SYSTEM AND MOVING OBJECT TRACKING SYSTEM | 05-16-2019 |
| 20220137030 | IN VITRO METHOD FOR ASSESSING THE RISK OF PROSTATE SIDE EFFECT AFTER TREATMENT BY IONIZING RADIATION - The present invention relates to an in vitro method for assessing the risk of developing side effects after ionizing radiation treatment in a prostate cancer subject, comprising the steps of a) measuring radiation induced T-lymphocytes apoptosis in a sample of the subject; b) determining the presence of urinary toxicity in the patient prior to application of ionizing radiation, and optionally of at least one other clinical parameter, disease parameter or ionizing radiation treatment parameter from the patient, and c) combining the value of the at least one biochemical marker measured in step (a) and a value associated with the at least one clinical parameter, disease parameter or ionizing radiation treatment parameter determined in step (b) in a mathematical function to obtain an end-value. | 05-05-2022 |
