| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 552553000 | Carbon bonded directly at the 17 beta-position of the cyclopentanohydrophenanthrene ring system is a member of an acyclic chain of three or four uninterruped carbons, (e.g., diketobisnorcholenic acids, etc.) | 15 |
| 20090270642 | Preparation of bile acids and intermediates thereof - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 10-29-2009 |
| 20100179337 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 07-15-2010 |
| 20110152552 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 06-23-2011 |
| 20110224448 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 09-15-2011 |
| 20130137884 | METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID - Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxy-steroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone. | 05-30-2013 |
| 20150112089 | DEUTERATED BILE ACIDS - This disclosure relates to deuterated bile acid compositions. A deuterated compound is selected from the disclosed groups of bile acids and their derivatives, analogs and salts. At least one of the hydrogen atoms in the compound is replaced with deuterium. | 04-23-2015 |
| 20150291651 | PROCESS FOR PREPARING HIGH PURITY URSODEOXYCHOLIC ACID - The present invention describes a process for the synthesis of ursodeoxycholic acid wherein the purification of the crude ursodeoxycholic acid (containing approximately 13-15% of chenodeoxycholic acid impurity) takes place first passing through a salification with imidazole and a subsequent purification via “methyl ester”, which allows a finished product with an extremely low content of known “cheno and “litho” impurities to be obtained. The present invention also describes the recovery steps of cholic acid and 3α-hydroxy-7-ketocholanic acid from the mother liquors of process intermediates. | 10-15-2015 |
| 20150291653 | PROCESS FOR PREPARING BILE ACID DERIVATIVES - The present invention relates to processes for preparing compounds of formula I: or a pharmaceutically acceptable salt or solvate thereof. | 10-15-2015 |
| 20150299245 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 10-22-2015 |
| 20160096862 | TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula A: | 04-07-2016 |
| 20160108082 | Preparation and Uses of Obeticholic Acid - The present invention relates to obeticholic acid: | 04-21-2016 |
| 20160176913 | Preparation and Uses of Obeticholic Acid | 06-23-2016 |
| 552554000 | Halogen or nitrogen containing (e.g., 20-cyano-pregnanes, 21-cyano pregnenes, etc.) | 1 |
| 20110295025 | PROCESS FOR THE PREPARATION OF CHOLYL-L-LYSINE - A process for the preparation of cholyl-L-lysine comprising the steps of: —(a) reacting N-ε-CBZ-cholyl-L-lysine with a hydrogen source in the presence of a catalyst in a solvent comprising one or more alkanols; (b) removing the catalyst; (c) optionally diluting the resulting reaction mixture with water and optionally adjusting the pH of the resultant reaction mixture to a pH less than or equal to about 4; (d) removing the bulk of the alkanol whilst ensuring that the alkanol content of the resultant mixture is maintained above about 3% w/w of the remaining mixture; (e) extracting the resultant mixture from step (d) with an organic solvent; (f) adjusting the pH of the aqueous layer to a pH of about 4.5 or greater to precipitate cholyl-L-lysine; (g) isolate the precipitate. | 12-01-2011 |
| 552555000 | Exactly one oxygen bonded directly to the cyclopentanohydrophenanthrene ring system (e.g., 3-keto-bisnorcholenic acids, 3-keto-bisnor-cholene-22 als, etc.) | 2 |
| 20100145083 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 06-10-2010 |
| 20130190517 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 07-25-2013 |
