| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 536250340 | Trivalent phosphorus compound utilized | 17 |
| 20090005550 | POLYNUCLEOTIDE CONTAINING A PHOSPHATE MIMETIC - The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is any organic substituent. | 01-01-2009 |
| 20090203897 | Method of Using Polymer Embedded Solid Supports for Small Scale Oligonucleotide Synthesis - A method of synthesizing oligonucleotides is claimed. The method utilizes a synthesis column incorporating a filter-like porous polymer cartridge which contains derivatized Controlled Pore Glass (CPG) or cross-linked Polystyrene (PS) directly embedded into the polymer cartridge. Small-scale synthesis of oligonucleotides of a predetermined sequence may be accomplished by introducing reagents of the phosphoramidite method into the synthesis column. These reagents flow through the cartridge allowing the reaction sequence to take place on the derivatized CPG or PS incorporated within the polymer cartridge. | 08-13-2009 |
| 20090306358 | SULFUR TRANSFER REAGENTS FOR OLIGONUCLEOTIDE SYNTHESIS - The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones as novel, efficient sulfur-transfer reagents is disclosed. The sulfur transfer from these reagents to compounds containing P(III) atom, triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite, was studied in solution by | 12-10-2009 |
| 20090312534 | METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP - A method is provided for efficiently removing the silicon substituent which protects the 3′-hydroxyl group and the 5′-hydroxyl group of a ribose of a ribonucleic acid derivative in which the 2′-hydroxyl group of the ribose is protected with the following substituent (I) | 12-17-2009 |
| 20100174058 | FLUORESCENT QUENCHING DETECTING REAGENTS AND METHODS - Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group. | 07-08-2010 |
| 20100273999 | Preparation of Nucleotide Oligomer - The present invention provides a method for preparing nucleotide oligomers, including (a) coupling a nucleotide dimer or nucleotide trimer to a nucleoside attached to solid supports or to universal solid supports as a starting material; (b) sequentially coupling nucleotide monomers to the resulting structures of Step (a) to prepare a nucleotide oligomer; and (c) removing the nucleotide oligomers from the solid supports. | 10-28-2010 |
| 20110065909 | SYNTHESIS OF OLIGONUCLEOTIDES - A method for preparing an oligonucleotide comprising the steps of | 03-17-2011 |
| 20110092693 | NOVEL COMPOUNDS - The present invention relates to a process for the preparation of an oligomeric compound made up of two or more individual oligomers, in which said oligomeric compound the individual oligomers are separated by a photocleavable linker, comprising the step of photoactively cleaving said linker. | 04-21-2011 |
| 20110137022 | METHOD FOR THE ANALYSIS OF OLIGONUCLEOTIDES - A method for the analysis of oligonucleotides is provided. The method comprises: desalting a mixture of oligonucleotides under conditions such that there is substantially no separation of the mixture of oligonucleotides, and/or by on-line desalting, introducing the desalted mixture of oligonucleotides into a mass spectrometer; and quantifying one or more oligonucleotides comprised in the mixture by mass spectrometry. | 06-09-2011 |
| 20110201799 | Synthesis of oligonucleotides - A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having formula (1), wherein B is a heterocyclic base, and radicals R | 08-18-2011 |
| 20120322994 | SYNTHESIS OF OLIGONUCLEOTIDES - A method for preparing an oligonucleotide comprising the steps of
| 12-20-2012 |
| 20130303745 | Synthesis of oligonucleotides - A method for preparing an oligonucleotide comprising the steps of synthesizing a phosphoramidite by reacting a hydroxyl-containing compound of formula (A) with a phosphitylating agent in the presence of an activator compound of formula (I), to prepare a phosphitylated compound, then coupling the phosphitylated compound without isolation with a second compound having the formula (A), wherein R | 11-14-2013 |
| 20140100362 | Process for Preparing Phosphate Compound Bearing Isotope - The present invention provides a process for preparing an isotope-containing phosphate compound easily. The process for preparing an isotope-containing phosphate compound according to the present invention includes the step of oxidizing a trivalent phosphorus compound with an oxidizing agent containing an isotope to synthesize a pentavalent phosphate compound to which the isotope has been introduced. The present invention preferably is applied to the synthesis of nucleic acids such as DNA and RNA, for example. The isotope preferably is a stable isotope. The oxidizing agent preferably is H | 04-10-2014 |
| 20140350234 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools - The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools. | 11-27-2014 |
| 20140350235 | IN SITU OLIGONUCLEOTIDE SYNTHESIS ON A PARAMAGNETIC SUPPORT - A novel method for attaching oligonucleotides to a paramagnetic solid support is disclosed. Conventional methods of attachment require that oligonucleotides be pre-synthesized with specific end modifications, which is laborious and expensive. Instead, we attached oligonucleotides to paramagnetic beads by direct synthesis of the oligonucleotides on the surface of the beads. An external magnet was used to hold the paramagnetic beads in place during solid-phase synthesis. A magnetic force was applied directly to the beads to prevent their loss, in particular, during reagent purge-to-waste steps that involved high-pressure drain or vacuum. This method can be adapted for use in any laboratory working with conventional synthesis automation, and can be employed, for example, with single columns and multi-well titer plates. | 11-27-2014 |
| 20150112053 | OLIGONUCLEOTIDE SYNTHESIS METHOD USING HIGHLY DISPERSIBLE LIQUID-PHASE SUPPORT - A nucleic acid synthesis method enabling a reaction in a fluid (flow) with a highly dispersible liquid-phase support to improve coupling efficiency is provided. | 04-23-2015 |
| 20150141637 | TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM - The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. | 05-21-2015 |
