| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 514254060 | Polycyclo ring system having the plural nitrogen containing additional five-membered hetero ring as one of the cyclos | 55 |
| 20080214567 | Benzimidazole Thiophene Compounds - The present invention provides benzimidazole thiophene compounds, pharmaceutical compositions containing the same, and their use as pharmaceutical agents. | 09-04-2008 |
| 20080227793 | Benzimidazole and Pyridylimidazole Derivatives - This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I | 09-18-2008 |
| 20080234290 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES AS CB1 INVERSE AGONISTS - Provided are compounds of the formula I: | 09-25-2008 |
| 20080242678 | Use of Flibanserin in the Treatment of Obesity - The invention relates to a method for the treatment of obesity and related diseases comprising the administration of a therapeutically effective amount of Flibanserin. | 10-02-2008 |
| 20080261997 | USE OF AMINOINDAZOLE DERIVATIVES FOR THE INHIBITION OF TAU PHOSPHORYLATION - The present invention relates to the use of novel derivatives of general formula (I) | 10-23-2008 |
| 20090005398 | Methods For The Treatment of Central Nervous System Tumors - Methods for the treatment of primary and secondary central nervous system tumors in a mammal which comprise administration of a benzimidazole thiophene compound are provided. | 01-01-2009 |
| 20090054458 | USE OF A POLYMORPH OF FLIBANSERIN FOR TREATING DISEASE - The invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments. | 02-26-2009 |
| 20090062304 | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex - This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. | 03-05-2009 |
| 20090069341 | INHIBITORS OF HSP90 - The invention relates to the use of benzoimidazolone compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising benzoimidazolone compounds, novel benzoimidazolone compounds, and a process for the preparation of the novel benzoimidazolone compounds. | 03-12-2009 |
| 20090124634 | Novel dipodazine compounds and applications - The invention relates to a novel class of dipodazine derivatives, suitable for use as surface on-growth inhibiting agents. | 05-14-2009 |
| 20090156613 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor - Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H | 06-18-2009 |
| 20090192169 | Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators - Compounds of Formula I: | 07-30-2009 |
| 20090209553 | Arylpiperazine derivatives and uses thereof - Compounds of the formula: | 08-20-2009 |
| 20090239880 | COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS - This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the invention. | 09-24-2009 |
| 20090239881 | Combinations of Flibanserin with Caffeine, Process for Their Preparation and Use Thereof as Medicaments - The invention is directed to a combination of flibanserin or a pharmaceutically acceptable derivative thereof and caffeine or a pharmaceutically acceptable derivative thereof for the treatment of Sexual Disorders in humans, particularly women. | 09-24-2009 |
| 20090247546 | Treatment of Prevention of Valvular Heart Disease with Flibanserin - The invention relates to a method for the treatment or prevention of Valvular Heart Disease comprising the administration of a therapeutically effective amount of flibanserin. | 10-01-2009 |
| 20090253711 | HETEROCYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS - The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. | 10-08-2009 |
| 20090318470 | 1-SUBSTITUTED-3-(NAPHTHALEN-1-YLSULFONYL)-5-(PIPERAZIN-1-YL)-1H-INDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS - The disclosure is directed to compounds of Formula I: | 12-24-2009 |
| 20100010008 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. | 01-14-2010 |
| 20100016331 | NOVEL COMPOUNDS - The present invention provides compounds of formula (I): | 01-21-2010 |
| 20100022557 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS - The invention relates to radioprotectors of formula (I), processes for their preparation and their use in protecting biological materials from radiation damage. In diagnostic and therapeutic radiology, particularly in cancer radiotherapy, the radioprotectors of the present invention may be used to protect certain normal tissues or structures from radiation damage. The radioprotectors of formula (I) may also have uses in decreasing the effects of irradiation in non-medical scenarios, both civil and military. | 01-28-2010 |
| 20100022558 | TREATMENT OF INSOMNIA - The invention relates to the use of Flibanserin for the preparation of medicaments useful for the treatment of Insomnia. | 01-28-2010 |
| 20100305140 | BENZIMIDAZOLE DERIVATIVES WHICH ARE TO BE USED AS ANTAGONIST FOR THE CB1-RECEPTOR - Compounds of formula I or pharmaceutically acceptable salts thereof: wherein X, A, R | 12-02-2010 |
| 20110015207 | SULFATED BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE RECEPTOR AFFINITY - The present invention pertains to compounds of general formula (I) | 01-20-2011 |
| 20110028490 | 4-PHENYL-PIPERAZIN-1-YL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE IN-HIBITORS - This invention relates to novel 4-phenyl-piperazin-1-yl-alkyl-benzoimidazol-2-one derivatives of structure (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention. | 02-03-2011 |
| 20110136825 | Treatment of Vasomotor Symptoms - The invention relates to a method for the treatment of vasomotor symptoms comprising the administration of a therapeutically effective amount of flibanserin. | 06-09-2011 |
| 20120035185 | Method of Using Flibanserin for Neuroprotection - The present invention relates to the use of 1-[2-(4-(3-trifluoromethyl-phenyl)piperazin-1-yl)ethyl]-2,3-dihydro-1H-benzimidazol-2-one, optionally in the form of its pharmaceutically acceptable acid addition salts and optionally in the form of its hydrates or solvates, for preparing a pharmaceutical composition with a neuroprotective activity. | 02-09-2012 |
| 20120122883 | NEW SALTS - The present invention relates to new crystalline salt forms of flibanserine which have valuable pharmacological properties, to a process for their manufacture, to pharmaceutical formulations containing them and to their use as medicament. | 05-17-2012 |
| 20120208827 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS - This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer. | 08-16-2012 |
| 20120220604 | PIPERAZINYL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS - The present application discloses novel piperazinyl-alkyl-benzoimidazol-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention discloses the use of these compounds in a method for therapy, and pharmaceutical compositions comprising the compounds of the invention. | 08-30-2012 |
| 20120270883 | USE OF A POLYMORPH OF FLIBANSERIN FOR TREATING DISEASE - The invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments. | 10-25-2012 |
| 20120277248 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. | 11-01-2012 |
| 20120322810 | NEW SALTS - The present invention relates to new crystalline salt forms of flibanserine which have valuable pharmacological properties, to a process for their manufacture, to pharmaceutical formulations containing them and to their use as medicament. | 12-20-2012 |
| 20130158047 | NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME - Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity. | 06-20-2013 |
| 20130217700 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT | 08-22-2013 |
| 20140005203 | Treatment of Vasomotor Symptoms | 01-02-2014 |
| 20140031365 | USE OF A POLYMORPH OF FLIBANSERIN FOR TREATING DISEASE - The invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments. | 01-30-2014 |
| 20140171443 | Monohydrate Crystalline Form of 3-(5-(4-(3-Fluoropropyl)-Piperazin-1-YL)Benzimidazol-2-YL)-1-Azaazulen-2-- One, Preparation, and Pharmaceutical Composition Thereof - The disclosure is directed to a monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, possessing diffraction peaks of about 12.9°, 15.9°, 17.9°, 21.2°, 22.9°, 23.5° and 24.5°. Its preparation method and pharmaceutical composition thereof are also provided. | 06-19-2014 |
| 20150011564 | Sulfated Benzimidazolone Derivatives Having Mixed Serotonine Receptor Affinity - The present invention pertains to a compound of formula (I) | 01-08-2015 |
| 20150051222 | PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2- -(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE - The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention. | 02-19-2015 |
| 20150057290 | METHOD OF USING FLIBANSERIN FOR NEUROPROTECTION - The present invention relates to the use of 1-[2-(4-(3-trifluoromethyl-phenyl)piperazin-1-yl)ethyl]-2,3-dihydro-1H-benzimidazol-2-one, optionally in the form of its pharmaceutically acceptable acid addition salts and optionally in the form of its hydrates or solvates, for preparing a pharmaceutical composition with a neuroprotective activity. | 02-26-2015 |
| 20150057291 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer. | 02-26-2015 |
| 20150057292 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer. | 02-26-2015 |
| 20150065520 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer. | 03-05-2015 |
| 20150072994 | Use of Flibanserin in the Treatment of Obesity - The invention relates to a method for the treatment of obesity and related diseases comprising the administration of a therapeutically effective amount of Flibanserin. | 03-12-2015 |
| 20150080410 | Cancer Specific Mitotic Network - Developed here is a mitotic network comprising a signature of up to 54 genes, and including also sub-sets of genes within the signature, which can identify members by requiring higher correlation values for a signature gene. The present mitotic network provides for methods for prognosis and diagnosis of various cancers. The mitotic network is conserved across cancers exhibiting aberrant mitotic activity and several genes in the network act as therapeutic targets. Development of other inhibitors of mitosis can apply expression values of the genes in the mitotic network from patient tissue to select patients during clinical validation of the new drugs. | 03-19-2015 |
| 20150126524 | Salts - The present invention relates to new crystalline salt forms of flibanserine which have valuable pharmacological properties, to a process for their manufacture, to pharmaceutical formulations containing them and to their use as medicament. | 05-07-2015 |
| 20150368204 | Sulfated Benzimidazolone Derivatives Having Mixed Serotonine Receptor Affinity - The present invention pertains to a compound of formula (I) | 12-24-2015 |
| 20160024085 | ALKYL-HETEROARYL SUBSTITUTED QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS - Disclosed herein are alkyl-heteroaryl substituted quinone derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. | 01-28-2016 |
| 20160075660 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT | 03-17-2016 |
| 20160095855 | USE OF A POLYMORPH OF FLIBANSERIN FOR TREATING DISEASE - The invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments. | 04-07-2016 |
| 20160095856 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer. | 04-07-2016 |
| 20160108003 | SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMID- AZOL-2-AMINE, PREPARATION THEREOF AND USE OF THE SAME - The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases. | 04-21-2016 |
| 20160108019 | INHIBITORS OF KRAS G12C MUTANT PROTEINS - Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): | 04-21-2016 |
| 20160136161 | Use of Flibanserin in the Treatment of Obesity - The invention relates to compositions for the treatment of obesity and related diseases comprising a) an active substance being not flibanserin, selected from the group consisting of active substances for the treatment of obesity and obesity related diseases and b) flibanserin, optionally in the form of pharmacologically acceptable acid addition salts thereof. | 05-19-2016 |
