| Entries |
| Document | Title | Date |
|---|
| 20080242676 | PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS - Novel pyrrole derivatives of formula (I) | 10-02-2008 |
| 20090176799 | PHOSPHODIESTERASE 4 INHIBITORS - Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: | 07-09-2009 |
| 20090215795 | CYCLIC AMIDINE DERIVATIVES - A cyclic amidine derivative represented by the formula: | 08-27-2009 |
| 20090281116 | PYRROLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The invention relates to compounds having the formula (I): | 11-12-2009 |
| 20090312345 | PHARMACOLOGICAL CHAPERONES FOR TREATING OBESITY - The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface. | 12-17-2009 |
| 20100048586 | MULTIFUNCTIONAL BIOACTIVE COMPOUNDS - The present invention discloses multifunctional bioactive compounds of formula (I) constituted of an immunoregulatory portion linked to a stabilizer moiety and pharmaceutical compositions thereof useful in the treatment of immune disorders and hemopoietic disorders such as immune cytopema, multiple myeloma, chronic lymphoid leucosis, lymphocytic lymphomas, lymphosarcomas. | 02-25-2010 |
| 20110237601 | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists - The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: | 09-29-2011 |
| 20120190689 | PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST - The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma, and various diseases related to CCR2. | 07-26-2012 |
| 20150320741 | DRUG COMBINATIONS COMPRISING A DGAT INHIBITOR AND A PPAR-AGONIST - The present invention relates to combinations of a DGAT inhibitor and a peroxisome proliferator-activator receptor (PPAR) agonist or a prodrug thereof. The invention further relates to methods for preparing such combinations, pharmaceutical compositions comprising said combinations as well as the use as a medicament of said combinations. | 11-12-2015 |
