| Entries |
| Document | Title | Date |
|---|
| 20080261958 | Combination of Organic Compounds - The present invention relates to a combination comprising: (a) an angiotensin II receptor blocker (ARB), or a pharmaceutically acceptable salt thereof; (b) a calcium channel blocker (CCB), or a pharmaceutically acceptable salt thereof; and (c) one of the two active agents selected from (i) a rennin inhibitor, or a pharmaceutically acceptable salt thereof; and (ii) a neutral endopeptidase (NEP) inhibitor, or a pharmaceutically acceptable salt thereof; for the prevention of, delay the onset of and/or treatment of cardiovascular disorders, which method comprises administering to a warm-blooded animal, in need thereof, a therapeutically effective amount of a combination of the present invention. | 10-23-2008 |
| 20080275031 | Inhibitors of C-FMS Kinase - The invention is directed to compounds of Formula I: | 11-06-2008 |
| 20080293701 | 1-Acylamino-2-Hydroxy-3-Amino- -Arylalkanes as Renin Inhibitors - 1-Acylamino-2-hydroxy-3-amino-ω-arylalkanes of formula I. and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients. | 11-27-2008 |
| 20080293702 | Nitric Oxide Enhancing Pyruvate Compounds, Compositions and Methods of Use - The invention provides novel compositions and kits comprising at least one nitric oxide enhancing pyruvate compound, or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension (n) treating reperfusion injury following ischemia; and/or (m) preserving tissues, organs, organ parts and/or limbs. The nitric oxide enhancing pyruvate compounds comprise at least one nitroxide group. | 11-27-2008 |
| 20080300238 | PHARMACEUTICAL COMPOSITION COMPRISING A RENIN INHIBITOR, A CALCIUM CHANNEL BLOCKER AND A DIURETIC - The invention relates to a pharmaceutical composition comprising (i) a renin inhibitor, (ii) a calcium channel blocker (CCB), and a diuretic and to a method of using such composition for the treatment of cardiovascular disease. | 12-04-2008 |
| 20080306052 | 3, 6-Dihydro-2-Oxo-6H-1,3,4,-Thiadiazine Derivatives - Compounds of the formula I, in which R1, R2, Q and B have the meanings indicated in claim | 12-11-2008 |
| 20080318936 | Substituted 5-Phenyl-3,6-Dihydro-2-Oxo-6H-1,3,4-Thiadiazines -
Compounds of the formula (I), in which R | 12-25-2008 |
| 20090023713 | HETEROCYCLIC COMPOUNDS - The invention is concerned with novel heterocyclyl compounds of formula (I) | 01-22-2009 |
| 20090042867 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE - The invention relates to substituted 1,2-ethylenediamines of general formula (I), | 02-12-2009 |
| 20090156584 | IRRADIATED COMPOSITIONS AND TREATMENT OF CANCERS WITH RADIATION IN COMBINATION WITH TAUROLIDINE AND/OR TAURULTAM - A composition formed by subjecting to ionizing radiation a combination containing a radiation-protective amount of PVP along with a solution, gel or adhesive including taurolidine, taurultam or a mixture thereof; or an aggregate including collagen-free crystals of taurolidine, taurultam or a mixture thereof. | 06-18-2009 |
| 20090163479 | USE OF TAUROLIDINE TO TREAT TUMORS - The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis. | 06-25-2009 |
| 20090247510 | Use Of Irbesartan For The Preparation Of Medicinal Products That Are Useful For Preventing or Treating Pulmonary Hypertension - The present invention relates to the use of irbesartan for the preparation of medicinal products that are useful for preventing or treating pulmonary arterial hypertension or pulmonary hypertension. | 10-01-2009 |
| 20090325940 | Substituted 1,2-ethylenediamines, Methods for Preparing Them and Uses Thereof - The present invention relates to substituted 1,2-ethylenediamines of general formula (I) | 12-31-2009 |
| 20100035865 | Sulfonamides and Pharmaceutical Compositions Thereof - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I). | 02-11-2010 |
| 20100041644 | STABILIZED SOLID PHARMACEUTICAL COMPOSITION OF CANDESARTAN CILEXETIL - The present invention relates to a solid pharmaceutical composition containing candesartan cilexetil as active ingredient and a stabilizing agent selected from the group consisting of esters of saturated fatty acids and monohydroxy alcohols, esters of hydroxycarboxylic acids and monohydroxy alcohols, ethers of C | 02-18-2010 |
| 20100048542 | METHODS AND COMPOSITIONS FOR TREATING PRIMARY AND SECONDARY TUMORS OF THE CENTRAL NERVOUS SYSTEM (CNS) - Methods and compositions for the treatment and/or prophylaxis and/or suppression of primary and/or secondary tumors of the central nervous system (brain and spinal cord, eyes) in mammalian subjects are disclosed, wherein an effective dose of a methylol transfer agent such as Taurolidine and/or Taurultam and/or a bioequivalent is administered to a mammalian subject suffering from, or at risk of growth of, tumors of the central nervous system. Furthermore, methods for local application of Taurolidine and/or Taurultam and/or a bioequivalent in solution are disclosed using microdialysis methods, irrigation methods, implantion methods and angiographic methods. | 02-25-2010 |
| 20100063033 | Methods of using substituted morpholine derivatives - The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use. | 03-11-2010 |
| 20100081649 | Treatment of cancers with methylol-containing compounds and at least one electrolyte - A method of inhibiting growth of a tumor cell in a mammal may include steps of administering to the mammal a first solution including a tumor-inhibiting methylol-containing compound, the first solution further including a first combination having a plurality of physiologically acceptable electrolytes or a second combination having at least one amino acid in combination with at least one physiologically acceptable electrolyte. Alternatively, another solution may be administered to the mammal containing a tumor-inhibiting methylol-containing compound, while concurrently administering to the mammal a further solution including the first combination with the plurality of physiologically acceptable electrolytes or the second combination with at least one said amino acid in combination with at least one physiologically acceptable electrolyte. | 04-01-2010 |
| 20100190777 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds of formula I active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. Formula (I) wherein Ar is optionally substituted heteroaryl; R | 07-29-2010 |
| 20100286129 | NOVEL BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME - The present invention relates to novel benzimidazole-dihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, to processes for the preparation thereof and to the use thereof in therapy, especially for the treatment of diabetes. | 11-11-2010 |
| 20100311733 | THIADIAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 12-09-2010 |
| 20110015188 | Treatment of Seasonal Conditions - Multi-dose active agent packages and methods for using the same for treating a subject for a condition are provided. Aspects of the invention include a multi-dose active agent package containing a plurality of unit dosage forms of an active agent configured to modulate at least a portion of a subject's autonomic nervous system during at least one season of the year. The active agent is present in an amount sufficient to alter the parasympathetic activity/sympathetic activity ratio of the subject in a manner effective to treat the subject for the condition. The subject active agent packages and methods find use in the treatment of a variety of different conditions, including disease conditions that increase in severity and/or occurrence during one or more seasons of the year. Also provided are kits for use in practicing the subject methods. | 01-20-2011 |
| 20110130391 | UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE - The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions. | 06-02-2011 |
| 20110172213 | ENHANCEMENT OF EFFECTIVENESS OF 5-FLUOROURACIL IN TREATMENT OF TUMOR METASTASES AND CANCER - Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof. | 07-14-2011 |
| 20110195960 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 08-11-2011 |
| 20120142676 | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules - Novel derivatives of dihydro-1,4,2-oxathiazine and dihydro-1,4-dithiine oxides, more particularly, novel derivatives of dihydro-1,4,2-oxathiazine and dihydro-1,4-dithiine oxides that target cysteine residues of biomolecules of pharmacological importance are provided as pharmaceutically useful compounds, for example, as anticancer, antiinfectious, antigastric acid secretion, antiosteoporosic, and antiinflammatory agents. | 06-07-2012 |
| 20130102594 | Pharmaceutical Formulation of Valsartan - The present invention relates to a pharmaceutical composition in a form of suspension for oral administration comprising valsartan or its pharmaceutically acceptable salts and at least one or two or more of the components selected from glycerol or syrup or the mixture thereof, a preservative, a buffer system and a suspending/stabilizing agent. The present invention further relates to the therapeutic uses of the pharmaceutical composition. | 04-25-2013 |
| 20130237531 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. | 09-12-2013 |
| 20130303524 | Carbazole-Containing Sulfonamides as Cryptochrome Modulators - The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R | 11-14-2013 |
| 20130331380 | DIHYDROINDOLONE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Compounds of formula (I): | 12-12-2013 |
| 20130338150 | DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF - The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia. | 12-19-2013 |
| 20130345207 | BENZYL-OXATHIAZINE DERIVATIVES SUBSTITUTED WITH ADAMANTANE AND NORADAMANTANE, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF - The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia. | 12-26-2013 |
| 20140038948 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. | 02-06-2014 |
| 20140066437 | OXATHIAZINE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL OR HETEROMETHYLENE GROUPS, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF - The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia. | 03-06-2014 |
| 20140155390 | NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS - The present invention relates to a compound of Formula 1, 2 or 3: | 06-05-2014 |
| 20140194412 | THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT - The present invention provides an anticancer drug having a Ras function inhibitory action. | 07-10-2014 |
| 20140206675 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R | 07-24-2014 |
| 20140296221 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): | 10-02-2014 |
| 20140296222 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): | 10-02-2014 |
| 20140296223 | METHOD FOR REGULATING SKIN PIGMENTATION - This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation. | 10-02-2014 |
| 20150051196 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 02-19-2015 |
| 20150307465 | Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): | 10-29-2015 |
| 20150353516 | IMINOTHIADIAZINE DIOXIDES CONTAINING A THIOAMIDE, AMIDINE, OR AMIDE OXIME GROUP AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain C2-ring-substituted iminothiadiazine compounds, or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers. The novel compounds of the invention are as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed. | 12-10-2015 |
| 20160016923 | S-IMINO-S-OXO-IMINOTHIADIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain S-imino-S-oxo iminothiadiazine compounds, including compounds Formula (I): or a tautomers and/or stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein R | 01-21-2016 |
| 20160159759 | OXATHIAZINE DERIVATIVES AS ANTIBACTERIAL AND ANTICANCER AGENTS - New oxathiazin-like compounds and their derivatives are useful as antineoplastic and antimicrobial agents. Compositions and methods of using oxathiazin-like compounds and their derivatives are disclosed. | 06-09-2016 |
| 20160168146 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | 06-16-2016 |
| 20160200732 | CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS | 07-14-2016 |
| 20170233383 | NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE | 08-17-2017 |
