| Entries |
| Document | Title | Date |
|---|
| 20080214528 | ANTI-INFECTIVE AGENTS - The present invention provides HCV polymerase inhibiting compounds having the formula (I): | 09-04-2008 |
| 20080255099 | Use of Diketodithiopiperazine Antibiotics for the Preparation of Antiangiogenic Pharmaceutical Compositions - The invention relates to the use of diketodithiopiperazine antibiotics, in particular chaetocin and gliotoxin, for the preparation of pharmaceutical compositions for antitumor therapy. | 10-16-2008 |
| 20080255100 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF - The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D | 10-16-2008 |
| 20090029974 | Tumor Treatment with Gliotoxin Derivatives - The present invention describes the use of Notch2 inhibitors for producing a medicament for the treatment of tumours, which tumours are characterised by ligand-independent Notch2 fragments. | 01-29-2009 |
| 20090042868 | Indoleamine 2,3-Dioxygenase (IDO) Inhibitors - Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure. | 02-12-2009 |
| 20090163480 | Modified amino acids, pharmaceuticals containing these compounds and method for their production - The present invention relates to modified amino acids of general formula | 06-25-2009 |
| 20090215754 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS - The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na | 08-27-2009 |
| 20090253687 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands - The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like. | 10-08-2009 |
| 20090264421 | Methods and Compositions for Treating Cancer - Compositions and methods for treating cancer, including hematologic cancers such as multiple myeloma, are disclosed. In some embodiments, chaetocin, chaetomin, or gliotoxin can be used to treat or ameliorate one or more symptoms or disorders associated with multiple myeloma. | 10-22-2009 |
| 20090306057 | [1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS - The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus. | 12-10-2009 |
| 20100168087 | BENZO[1,2,3]THIADIAZINE DERIVATES - The present invention relates to new benzo[1,2,3]thiadiazine-1,1-dioxide derivatives of the general Formula (I), medicaments containing such compounds and the use thereof in the medicine. Benzo[1,2,3]thiadiazine-1,1-dioxide derivatives of the general Formula (I) are suitable for the prevention or treatment of the diseases of the central nervous system. | 07-01-2010 |
| 20100184749 | BENZOTHIADIAZINE COMPOUNDS AND THEIR USE - Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. | 07-22-2010 |
| 20100190778 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE - The present invention is related to new 3,4-dihydroberizo[1,2,3]thiadiazine-1,1-dioxide derivatives of the Formula (I), medicaments containing said new compounds, process for the preparation thereof and the use of said derivatives in the medicine. The compounds according to the present invention are suitable for the treatment or prevention of disorders of the central nervous system. | 07-29-2010 |
| 20100261714 | INHIBITORS OF HIV REPLICATION - Compounds of formula (I): | 10-14-2010 |
| 20100267703 | 4-Amino-1,2,3-benzoxathiazine-Derivatives as Pesticides - The present invention relates to novel benzoxathiazine derivatives of the formula (I) | 10-21-2010 |
| 20100305109 | POTASSIUM CHANNEL MODULATORS - Disclosed herein are KCNQ potassium channels modulators of formula (I) | 12-02-2010 |
| 20110071141 | Pesticidial Condensed-Ring Aryl Compounds - Condensed-ring aryl compounds of formula (I) and use of the same as a agrochemical for controlling noxious organisms wherein (X) | 03-24-2011 |
| 20110112079 | PHOSPHODIESTERASE INHIBITORS - The invention related to compounds for formula I useful for inhibiting phosphodiesterase-4. | 05-12-2011 |
| 20110207723 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE - A compound represented by the general formula (I): | 08-25-2011 |
| 20120035160 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE - Compounds derived from imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides, for use as a drug or pharmaceutical composition for treatment of parasitic diseases, preferably of diseases caused by parasites of the | 02-09-2012 |
| 20120094983 | ACYCLIC IKUR INHIBITORS - A compound of formula I | 04-19-2012 |
| 20120214803 | Novel Sulfonaminoquinoline Hepcidin Antagonists - The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases. | 08-23-2012 |
| 20120232068 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS - A compound of formula (I) wherein A, X, Y, Z, R | 09-13-2012 |
| 20130184266 | HETEROCYCLIC COMPOUND AND USE THEREOF - Provided is a compound represented by the formula (I): | 07-18-2013 |
| 20140031345 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS - A compound of formula I | 01-30-2014 |
| 20140080817 | HETEROCYCLIC COMPOUND AND USE THEREOF - Provided is a compound represented by the formula (I): | 03-20-2014 |
| 20140094453 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions. | 04-03-2014 |
| 20140235623 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands. | 08-21-2014 |
| 20140235624 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions. | 08-21-2014 |
| 20140364424 | Novel Sulfonaminoquinoline Hepcidin Antagonists - The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases. | 12-11-2014 |
| 20150031684 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions. | 01-29-2015 |
| 20150038496 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TH2 MEDIATED DISEASES - The present invention relates to methods and pharmaceutical composition for the treatment of T-helper type 2 (Th2)-mediated diseases. More particularly, the present invention relates to an inhibitor of the Suv39h1-HP1a silencing pathway for use in the treatment of a T-helper type 2 (Th2)-mediated disease, in particular allergic asthma. | 02-05-2015 |
| 20150344501 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE - Compounds and salts thereof which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include triazolothiadiazines, particularly 3,6,7 -substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 4-(1H-pyrrol-3-yl) thiazoles, particularly 4-(1,2,5-substituted-1H-pyrrol-3-yl)-2-substituted thiazoles, and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens including mycobacterium, for example, | 12-03-2015 |
| 20150361062 | HETEROCYCLO COMPOUNDS AS APOPTOTIC INDUCERS AND USES THEREOF - Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein X, R | 12-17-2015 |
| 20160185799 | ACC INHIBITORS AND USES THEREOF - The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same. | 06-30-2016 |
