| Entries |
| Document | Title | Date |
|---|
| 20080255089 | Triphenylethylene Compounds Useful as Selective Estrogen Receptor Modulators - Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation. | 10-16-2008 |
| 20080261952 | Aryl Urea Derivatives for Treating Obesity - A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment. | 10-23-2008 |
| 20090054401 | Substituted bicyclic derivatives and use thereof - [Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action.
| 02-26-2009 |
| 20090075975 | ARYLSULFONAMIDES AND USES RELATED THERETO - Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: | 03-19-2009 |
| 20090105218 | CRTH2 Receptor Ligands For Therapeutic Use - Compounds of formula (I) are useful in the treatment of disease responsive to modulation of CRTH2 receptor activity, wherein: A represents a carboxyl group —COOH, or a carboxyl bioisostere; L1 is a bond, —CH | 04-23-2009 |
| 20090118257 | 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES - Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 4-(p-quinolyl)-2-hydroxybutanamide derivatives. Methods and compounds useful in treating other disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease, and pervasive developmental disorders such as autism are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed. | 05-07-2009 |
| 20090209514 | Tetrahydro-Naphthalene Derivatives as Vanilloid Receptor Antagonists - This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydronaphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD. | 08-20-2009 |
| 20100029613 | TREATMENT AND PREVENTION OF EPILEPSY - The present invention is directed to a method of treating or preventing epileptic seizures in a subject and a method of inhibiting hypersynchronous burst activity of neurons by administering an agent which interferes with glutamate, aspartate, and/or ATP release from astrocytes. Also presented is a method of identifying agents suitable for treating or preventing epileptic seizures. | 02-04-2010 |
| 20100249101 | MALONAMIDE DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY - The present invention relates to compounds of formula I, | 09-30-2010 |
| 20110136787 | DIPHENYL AZEPANE, DIAZEPANE AND OXAZEPANE DERIVATIVES AND USES THEREOF - Compounds of the formula I: | 06-09-2011 |
| 20110281844 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS - Use of a compound of formula (A), wherein: | 11-17-2011 |
| 20120094977 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION - Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression. | 04-19-2012 |
| 20120165315 | MEPTAZINOL CARBAMATE PRODRUG SALTS - The present invention relates to salts of meptazinol carbamate prodrugs, and to their synthesis and use. | 06-28-2012 |
| 20120258954 | ArylSulfonamide Based Matrix Metalloprotease Inhibitors - The present invention provides a compound of formula (I): | 10-11-2012 |
| 20130096105 | ArylSulfonamide Based Matrix Metalloprotease Inhibitors - The present invention provides a compound of formula (I): | 04-18-2013 |
| 20130203733 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES - The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another. | 08-08-2013 |
| 20140179681 | METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT - Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR. | 06-26-2014 |
| 20140336178 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES - The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another. | 11-13-2014 |
| 20140357619 | Apparatus for applying health treatment. - An apparatus to apply antiseptic treatment while providing the benefits of a moisturizer. A method for using the apparatus whereby the antiseptic treatment is applied to a body orifice via a squeeze tube, a twist up stick tube or by using a finger to retrieve the antiseptic treatment from a small jar with a twist-off top to help provide a protectant that reduces a body's intake of harmful microbes. | 12-04-2014 |
| 20150072971 | Methods for Treating Depressive Symptoms - The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A. | 03-12-2015 |
| 20160016892 | BICYCLIC ANALGESIC COMPOUNDS - Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein. | 01-21-2016 |
| 20160374968 | BICYCLIC ANALGESIC COMPOUNDS - Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein. | 12-29-2016 |
