| Entries |
| Document | Title | Date |
|---|
| 20080199947 | Blood cell analyzer, blood cell analyzing method, and computer program product - A blood cell analyzer is provided with a first detection unit for electrically detecting blood cells in blood sample; a second detection unit for optically detecting blood cells in blood sample; a volume information obtainer for obtaining volume information of red blood cells based on the electrically detected blood cells; a scattered light intensity information obtainer for obtaining a scattered light intensity of red blood cells based on the optically detected blood cells; a first histogram preparer for preparing a first histogram of the volume information of each of red blood cells; a second histogram preparer for preparing a second histogram of the scattered light intensity information of each of red blood cells; a display unit; and a data processor for preparing a screen for displaying on the display unit, the screen including the first and second histograms. | 08-21-2008 |
| 20080199948 | SYSTEM FOR DETECTING INFECTIOUS AGENTS USING COMPUTER-CONTROLLED AUTOMATED IMAGE ANALYSIS - A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object. | 08-21-2008 |
| 20080199949 | DEVICE FOR SAMPLING BLOOD DROPLETS UNDER VACUUM CONDITIONS - A blood extraction device ( | 08-21-2008 |
| 20080213875 | ASSAY DEVICES AND METHODS - A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor. | 09-04-2008 |
| 20080220512 | Tunable laser-based spectroscopy system for non-invasively measuring body water content - The present disclosure relates to a tunable laser-based spectroscopy system for accurately and non-invasively measuring body water content. The body water content is one of the important health indicators, by which one can quantitatively monitor the hydration level of body and determine if it is necessary to supplement or reduce the body water. The disclosed systems, devices, and/or methods may improve wavelength accuracy, wavelength resolution, optical spectral power density, signal-to-noise ration, and available implementation options for the spectroscopy system. | 09-11-2008 |
| 20080227187 | Cellular physiology workstations for automated data acquisition and perfusion control - Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological experiments. Methods for employing such cellular physiology workstations in physiological and electrophysiological experiments are also disclosed. The cellular physiology workstations comprise one or more recording chambers each for holding one or more cells to be measured. One or more cells are place in each recording chamber. Perfusions means, such as an automatic perfusion system is connected to the recording chamber to perfuse the cells with a plurality of solutions containing different concentration of one or more agents to be tested. Biosensors, such as patch clamps, electrodes, or microscopes are positioned to detect a response from the cell. The cellular physiology workstation may optionally comprise injecting means for introducing an injection solution into the cell before and during analysis. | 09-18-2008 |
| 20080227188 | Biosensor with Optically Matched Substrate - The matching of refractive index of a nanoporous membrane with an analyte solution used with the membrane for use in a sensor is described. Scattering of the excitation and/or emitted light is reduced by matching the refractive indices. This improves efficiency when the porous translucent membrane is used in flow-through or flow-over sensors such as biosensors. | 09-18-2008 |
| 20080254531 | APPARATUS FOR THE NON-INVASIVE MEASUREMENT OF TISSUE FUNCTION AND METABOLISM BY DETERMINATION OF STEADY-STATE FLUORESCENCE ANISOTROPY - A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control. | 10-16-2008 |
| 20080254532 | Thermal cycler with optical detector - A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls. | 10-16-2008 |
| 20080286858 | Reaction vessel with integrated optical and fluid control elements - The present invention provides disposable, semi-reusable, or single use reaction vessels with integrated optical elements for use with diffraction based assay systems. The vessel for assaying liquids for analytes includes a housing having at least one chamber or well for receiving a liquid therein and an optical element integrally formed with the housing for directing an incident light beam towards the well or chamber and directing a light beam away from the reaction chamber after the light beam has interacted with analytes present in the liquid. | 11-20-2008 |
| 20080293130 | BIOCHIP - A biochip that can make optical measurements without being affected by background fluorescence etc., originating from the outside environment, wherein the surface of the substrate of the biochip can be chemically treated by a simple procedure. The biochip has at least a nontransparent resin substrate, an immobilizing layer formed on a part of the non-transparent resin substrate, and an organic molecule immobilized on the immobilizing layer, and detects an analyte labeled with fluorescence or luminescence in a sample, from the intensity of the fluorescence or luminescence. | 11-27-2008 |
| 20080318307 | Incubation Condition Monitoring Device - An incubation condition monitoring device has at least one reader unit ( | 12-25-2008 |
| 20090004730 | Cell Obsevation Aiding Instrument and Method of Cell Observation Therewith - A cell observation support instrument having opposed first and second surface members | 01-01-2009 |
| 20090023203 | Sensor Device for Interrogation of Changes in the Contents of a Sealed Container - A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet provides information on quality of the contents of the primary container without breaking the sealed system. The integral sensor device includes a biosensor retained within a plastic construct by a gated-pore membrane. Pores in the membrane open in response to an environmental change in the primary container allowing the contents of the primary container to contact the biosensor. Status of the contents of the primary container can be determined by inspection of the biosensor, visually or via a fiberoptic probe, through the optical window of the plastic construct. | 01-22-2009 |
| 20090029453 | DEVICES FOR THE DETECTION OF MULTIPLE ANALYTES IN A SAMPLE - The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore. | 01-29-2009 |
| 20090068726 | Optical Device for Blood Analysis, Analysis Apparatus Equipped With Such a Device - Optical device ( | 03-12-2009 |
| 20090081769 | Apparatus for judging cell detachment, method of judging cell detachment, and cell culture apparatus - An apparatus for judging cell detachment that judges a state of detachment of cells that have been cultured within a cell culture container (cultured cells), includes: an image-capturing unit that captures an image of the cultured cells; and a detachment state judging unit that determines luminance information within the cell culture container based upon image capture data from the image-capturing unit, and judges that the culture cells are detached when the luminance information exceeds a predetermined luminance level. | 03-26-2009 |
| 20090093046 | Incubation apparatus - An incubation apparatus, including a temperature-controlled room adjusted to be a predetermined environment condition, and incubating a sample of an incubation container inside the temperature-controlled room, includes a carrying apparatus, an imaging section, and an image analyzing section. The carrying apparatus carries the incubation container in the temperature-controlled room. The imaging section photographs a whole of the incubation container inside the temperature-controlled room. The image analyzing section analyses an operation state of the incubation apparatus or an incubating environment state of the sample based on a total observing image of the incubation container photographed at the imaging section, and outputs an error signal notifying an abnormality of the operation state or the incubating environment state in accordance with the analysis result. | 04-09-2009 |
| 20090093047 | Kit and Device for Generating Chemiluminescence Radiation - A device for generating a chemiluminescence radiation depending on the binding of at least one ligand that is contained in a sample that is to be tested to at least one receptor that is binding-specific for the ligand has a flow cell having an internal cavity. The internal cavity has a separating wall on which the at least one receptor is immobilized. The internal cavity has at least two compartments. In a first compartment solid is deposited that contains at least one peroxidase-enzyme-possessing marker for marking the ligand in lyophilized form. A second compartment contains salt-stabilized luminol and a solid substance that releases hydrogen peroxide upon contact with water. | 04-09-2009 |
| 20090111173 | Micro-Organism Test Apparatus and Methods of Using the Same - A micro-organism testing apparatus comprising a multi-compartment resealable container provided with or adapted to receive a growth medium ( | 04-30-2009 |
| 20090111174 | Biomolecule analyzing system - A biomolecule analyzing system ( | 04-30-2009 |
| 20090137030 | Incubator, schedule management method, and program - An input section of an incubator accepts, from a user, a first input selecting a specified incubation container which registers an observing schedule, and a second input specifying an imaging condition of the specified incubation container in an observing sequence. A calculating section calculates, according to the above-mentioned imaging condition, an observing duration of the specified incubation container from a first data relating to a carrying period of an incubation container and a second data with regard to an imaging duration. A schedule management section extracts, based on a schedule data, a registrable time zone in which an observing sequence of the specified incubation container can be executed without overlapping with previously registered observing schedules, and outputs to display the registrable time zone for presentation to the user. | 05-28-2009 |
| 20090170189 | MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME - Provided are a microfluidic device that performs a biochemical reaction using a small amount of a biochemical fluid and detects the result thereof, and a method of fabricating the same. The microfluidic device includes: a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and a film welded on the bottom surface of the substrate to seal the chamber so that the chamber is not open at the bottom surface of the substrate, and formed of polymer. The method of fabricating a microfluidic device includes: preparing a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and welding a film on a bottom surface of the substrate to seal the chamber so that the chamber is not opened at the bottom surface of the substrate, the film being formed of polymer. | 07-02-2009 |
| 20090191617 | BIO CHIP AND RELATED TECHNOLOGIES INCLUDING APPARATUS FOR ANALYZING BIOLOGICAL MATERIAL - The bio chip and the apparatus for analyzing biological material are disclosed, the bio chip and the apparatus being capable of analyzing a variety of specific materials included in biological materials using a single bio chip injected with a single biological material, capable of conducting an optical measurement and an electro-chemical measurement to the enhancement of efficiency, capable of forming a sterilizer at the bio chip to enable a swift disinfection of vulnus caused by blood collection to the convenience of a user, and capable of mounting a laser beam source at the apparatus to enable a swift blood collection, wherein the apparatus is provided with a transfer unit for transferring the bio chip having a sterilizer, whereby the bio chip is transferred following the blood collection to enable automatic disinfection and analysis. | 07-30-2009 |
| 20090191618 | REACTION CHAMBER FOR REAL TIME PCR COMPRISING CAPTURE PROBES AND PERMITTING DETECTION OF THE PCR PRODUCT BY HYBRIDISATION WITHOUT OPENING THE PCR VESSEL - A reaction chamber ( | 07-30-2009 |
| 20090191619 | METHOD AND DEVICE FOR SELECTIVELY TARGETING CELLS WITHIN A THREE-DIMENSIONAL SPECIMEN - The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector including at least one camera, wherein the detector is capable of resolving a particle of interest within the specimen; (c) a means for locating the particle of interest in three dimensions; (d) a means for focusing electromagnetic radiation to a focal volume within the specimen; and (e) a means for adjusting the relative positions of the stage and electromagnetic radiation focusing means, thereby positioning the particle of interest within the focal volume. | 07-30-2009 |
| 20090203118 | OPTICAL SYSTEM INCLUDING NANOSTRUCTURES FOR BIOLOGICAL OR CHEMICAL SENSING - An analytical device is disclosed. In one embodiment, the analytical device includes a three-dimensional substrate structure comprising a three-dimensional surface. A plurality of noble metal nanoparticles are on the three-dimensional substrate structure. A plurality of capture agents are on the noble metal nanoparticles. | 08-13-2009 |
| 20090209029 | HIGH-DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS - The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips. | 08-20-2009 |
| 20090215161 | MICROORGANISM TESTING DEVICE AND CHIP FOR TESTING MICROORGANISMS - There is disclosed a microorganism testing device in which various types of microorganisms can be easily concentrated. The microorganism testing device includes a detection chip, a carrier device, a controller, and a magnet. The detection chip includes a specimen container for holding a specimen containing microorganisms, a trapping particle liquid container for holding trapping particle liquid containing magnetic particles, a microorganism trapping section for trapping the microorganisms, and a liquid flow path. In a state where a magnetic force of the magnet acts on the microorganism trapping section, the controller controls the carrier device to flow the trapping particle liquid into the microorganism trapping section to form a filtration filter by trapping plural magnetic particles in the microorganism trapping section, and in this state, to flow the microorganisms into the microorganism trapping section so that the microorganisms within the specimen are deposited on one side of the filtration filter. | 08-27-2009 |
| 20090233350 | RESPIRATORY APPARATUS WITH A BIOBURDEN INDICATOR - A respiratory apparatus includes a bioburden indicator, having an input valve for the entry of air to be analysed, an element for bioburden analysis, and a suction valve suited to be connected to a suction system to suck up the air to be analysed. | 09-17-2009 |
| 20090246862 | BIOLUMINOGENIC ASSAY SYSTEM FOR MEASURING BETA-LACTAMASE ACTIVITY - A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic substrate; co-exposing the bioluminogenic substrate to a bioluminescence indicator reaction that employs the bioluminescence initiating compound as a substrate; and detecting a light from the bioluminescence indicator reaction as a measure of the activity of the beta-lactamase enzyme. | 10-01-2009 |
| 20090291488 | MICROORGANISM TESTING DEVICE AND MICROORGANISM TESTING CHIP - A microorganism testing device includes: an analysis chip that includes a fluid specimen container, a reaction container for causing the fluid specimen to react with a reagent solution, a microorganism detection flow path, and an alignment reagent container for holding an alignment reagent to be used in an alignment work of the microorganism detection flow path; a moving stage for holding the analysis chip; and a detection device including a light source for irradiating the detection flow path with light, and an optical detector for detecting light from the detection flow path and converting the light into electric signals, in which the alignment reagent container is provided on a downstream side of the specimen container and the reaction container. | 11-26-2009 |
| 20090298162 | BIOSENSORS FOR MONITORING RECEPTOR-MEDIATED G-PROTEIN ACTIVATION - The present invention relates to novel biosensors that are based on bioluminescence resonance energy transfer (BRET). These biosensors may be used to monitor rapid interaction and conformational changes within G protein-coupled receptor/G protein complexes and, in this way, reflect the activation status of the receptor. Advantageously, the biosensors may be used as a highly sensitive and quantitative assay for the identification of ligands (agonists, antagonists, inverse agonists, partial agonists, etc.) targeting G protein-coupled receptors (GPCRs) as well as for the analysis of the activation status of these receptors. Moreover, multiplexing different biosensors within receptors/G protein complexes allows for mapping ligand textures. Additionally, the biosensors permit the direct, real-time examination of interactions between receptors and G protein in their natural environment, the living cell. | 12-03-2009 |
| 20090311774 | BIOASSAY SYSTEM INCLUDING OPTICAL DETECTION APPARATUSES, AND METHOD FOR DETECTING BIOMOLECULES - A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule. | 12-17-2009 |
| 20090325280 | CULTURE OBSERVATION SYSTEM - There is provided a culture observation system by which even a culture other than an observation target culture can be cultured and observation can be properly performed by a microscope during culturing of the culture. A culture observation system S includes a culturing cabinet | 12-31-2009 |
| 20100003743 | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor - A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used. | 01-07-2010 |
| 20100003744 | FLOW CYTOMETER FOR DIAGNOSIS OF HIV INFECTIONS - Disclosed is a a flow cytometer for diagnosis of HIV infections. A fluorescent material having a relatively lower fluorescence intensity is conjugated with one marker and another fluorescent material having a relatively higher fluorescence intensity is conjugated with the other marker. The two markers can be sorted and counted individually and simultaneously from the fluorescence intensity difference. | 01-07-2010 |
| 20100015691 | Apparatus for Hemolyzing a Blood Sample and for Measuring at Least One Parameter Thereof - An apparatus for hemolyzing a blood sample and for measuring at least one parameter thereof comprises a sample chamber for accommodation of the blood sample, the sample chamber having a first sidewall and an opposite second sidewall. The apparatus also comprises ultrasonic generator for generating ultrasonic waves in the first and second sidewalls so as to cause the blood sample provided between the first and second sidewall to be hemolyzed. Further, the apparatus comprises an optical measuring device for measuring the at least one parameter in the hemolyzed blood sample when the hemolyzed blood sample is provided between the first and second sidewalls. The ultrasonic generator of the apparatus comprises a first ultrasonic generator for generating ultrasonic waves in the first sidewall and a second ultrasonic generator for generating ultrasonic waves in the second sidewall. | 01-21-2010 |
| 20100015692 | Small Volume In Vitro Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 01-21-2010 |
| 20100021994 | APPARATUS FOR DETERMINING THE TERMINATION OF FAT DIGESTION AND FAT TISSUE DIGESTION APPARATUS - To enable to yield a group of fat-derived stem cells of constant quality regardless of the individual difference in fat tissue. It is intended to provide an apparatus for determining the termination of fat digestion ( | 01-28-2010 |
| 20100028989 | MONITOR DEVICE AND BIOLOGICAL COMPONENT-MEASURING DEVICE - This invention provides a monitor device capable of detecting possible abnormalities in body fluid withdrawal by a body fluid sampler and variations in the dilution when a withdrawn body fluid is diluted, and a living organism-measuring device with this monitor device. The former device includes a first optical sensor disposed on a diluent channel through which a diluent is introduced into a body fluid sampler for withdrawing a body fluid; a second optical sensor disposed on a diluted body fluid channel through which the diluted body fluid is transferred to a living organism-measuring sensor, and close to the first optical sensor; and a controlling unit for judging whether variations in a dilution to which the body fluid is diluted are within predetermined limits, from data outputted by the first optical sensor and data outputted by the second optical sensor. The latter device has the monitor device incorporated thereto. | 02-04-2010 |
| 20100075408 | Device for microbiological analysis - The device for the microbiological analysis of a support ( | 03-25-2010 |
| 20100075409 | Device for microbiological analysis - The device for the microbiological analysis of a support adapted to contain microorganisms marked by a fluorophore agent, said agent being adapted to absorb light energy with an absorption spectrum ( | 03-25-2010 |
| 20100081190 | Histological facilitation systems and methods - Systems, methods, and other modalities are described for generating or otherwise handling images or other data indicating (a) an extraction of chemically treated tissue frozen in vivo, (b) a treatment of a tissue sample in a chamber extended into tissue of an organism, and/or (c) cells to which an optical enhancement material was applied in vivo. Several contexts in which such indications facilitate histological evaluation are likewise described. | 04-01-2010 |
| 20100093072 | MICROORGANISM TESTING DEVICE AND MICROORGANISM TESTING CHIP - Provided are a microorganism testing chip capable of suppressing self-fluorescence and enhancing mass productivity, and a microorganism testing device using the same. The microorganism testing chip includes a main body and a fungus body detection unit mounted on the main body. The main body has a detection window frame portion which is a through-hole or a pass-through groove. The fungus body detection unit is disposed to cover the detection window frame portion and has a fungus body detection flow path connected to flow paths provided in the main body. The fungus body detection unit includes a cover member and a flow path member, and is formed by attaching these two members to each other. The flow path member has a groove. By attaching the two members to each other, the groove of the flow path member serves as the fungus body detection flow path. | 04-15-2010 |
| 20100099177 | In-situ optical monitoring subsystem compatible with cell incubators - An optical monitoring subsystem includes: a differential interference contrast (DIC) optical-path apparatus having a CCD camera and enclosed in a gas-tight housing stored in an incubator and a three-dimension electric driving device operatively moving along three axes of three-dimension coordinates for conveniently observing, monitoring or photographing cells in a cell specimen placed in a concave platform as recessed in the gas-tight housing, and a control device operatively controlling the free movement of the DIC optical-path apparatus; whereby the cells may be directly observed or monitored in-situ in the incubator in a three-dimensional way. | 04-22-2010 |
| 20100099178 | Contaminant Detection Apparatus - A contaminant detection apparatus comprising a powered portable detection device for detecting the presence of at least one pathogen in a sample; a test applicator kit comprising a sample applicator and a cartridge configured to receive and retain the sample applicator; the sample applicator including a swab having a first and second swab heads for swabbing a surface to obtain a sample, the cartridge and sample applicator being configured such that when the sample applicator is retained in the cartridge, the first swab head is retained in said preserving chamber to preserve a confirmatory version of said sample, and the second swab head is positioned in the solvent chamber to dissolve the second swab head to a substantially liquid mixture including said sample, and permit the mixture to flow via flow paths to the wells. | 04-22-2010 |
| 20100099179 | CHROMATOGRAPHY QUANTITATIVE MEASURING APPARATUS - In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily. | 04-22-2010 |
| 20100112682 | TOTAL BACTERIA MONITORING SYSTEM - A system for measuring total microbiological content in an aqueous medium by adding a fluorescent dye to the aqueous medium, measuring the fluorescent signal in the aqueous medium to obtain a baseline fluorescent signal, releasing intracellular content of the microbiological matter into the aqueous medium by lysing the microbiological matter. The system then measures the fluorescent signal in the aqueous medium with the released intracellular content of the microbiological matter to obtain a second fluorescent signal. Next, the system subtracts the baseline signal from the second fluorescent signal to obtain a net fluorescent signal and equates the net fluorescent signal with a microbiological content. | 05-06-2010 |
| 20100120133 | Separation device for use in the separation, characterization and/or identification of microorganisms - The present invention is directed to a separation device or container that can be used in the separation, isolation or pelleting of microorganisms from a test samples known to contain or suspected of containing said microorganisms. Subsequently, the separated, isolated or pelleted microorganism sample can undergo one or more interrogation steps to provide measurements useful for the characterization and/or identification of microorganism. In one aspect of the present invention, the interrogation steps can occur in situ in the separation device or container described herein. | 05-13-2010 |
| 20100129899 | Flexible Bioreactor - A flexible bioreactor intended for culturing cells in a liquid medium, the bioreactor comprising a flexible wall forming a fluid impermeable bottom wall of the bioreactor when in use, wherein flexible parts of said flexible bottom wall are interrupted by at least one rigid element of said flexible bottom wall, the rigid element and the flexible parts being connected fluid tightly, and wherein the rigid element comprises measuring means allowing for non-invasive monitoring of cellular activity in said bioreactor when in use. | 05-27-2010 |
| 20100151564 | Biological Work Station - A biological work station for culturing and monitoring cells includes a laminar flow bench and an incubator disposed on the bench. The bench includes a work surface adjacent the incubator that allows experiments and other manipulations to be performed within the confines of the laminar flow bench. An imaging system, such as a stereoscope, may be mounted to the bench so that images may be captured of a culture without removal of the culture from the incubator. | 06-17-2010 |
| 20100159576 | BIOCHIP AND BIOMATERIAL DETECTION APPARATUS - Provided are a biochip and a biomaterial detection apparatus. The biochip includes a substrate, a metal layer, and a dielectric layer. The substrate includes a surface having a plurality of acute parts which are formed by first and second inclined planes. The metal layer is formed on at least one of the first and second inclined planes. The dielectric layer is formed on the metal layer, and capture molecules specifically binding to target molecules which are marked with a fluorescent substance are immobilized to a surface of the dielectric layer. | 06-24-2010 |
| 20100167387 | SYSTEM AND AUTOMATED DEVICE FOR ANALYSING A CELL SUSPENSION - A system for analyzing a cell suspension includes at least one well for decanting ( | 07-01-2010 |
| 20100173398 | Hand-held microfluidic testing device - A hand-held microfluidic testing device is provided. The testing device includes a housing having at least one cartridge receiving port and at least one cartridge for inputting to the cartridge receiving port, and an optical detection system in the housing, where the optical detection system is disposed to analyze at least one sample in the in at least one detection channel of the cartridge. The cartridge includes at least one sample inlet and sample outlet, at least one buffer inlet and buffer outlet, at least one detection material inlet and outlet, at least one calibration standard inlet and calibration standard outlet and a detection window disposed above a detection region of a channel, where the analysis cartridge is surrounded by a protective shell, that holds the analysis chip base, a chip lid, a sealing gasket, and protective film cover. | 07-08-2010 |
| 20100178692 | MODEL CELL CHIP, APPARATUS FOR EVALUATING DRUG EFFECT USING THE MODEL CELL CHIP AND METHOD OF EVALUATING DRUG EFFECT - The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo. | 07-15-2010 |
| 20100216228 | MICROARRAY WITH MICROCHANNELS - A microarray formed in a planar surface of a moldable slab, the microarray including a plurality of microwell sets comprising a plurality of microwells formed in the planar surface of the moldable slab, each microwell being sized to contain at least a single cell, and a plurality of microchannels formed in the planar surface of the moldable slab, the plurality of microchannels being configured to permit liquid from a first region of the microarray to transit to a second region of the microarray. | 08-26-2010 |
| 20100221817 | Whole-Cell Sensor - The invention relates to whole-cell sensors for monitoring bioavailable nitrogen, phosphorus and sulphur, individually or in at least one combination in a medium, and to the use thereof. The whole-cell sensors consist of genetically modified yeast cells which are immobilised in a xerogel matrix and contain at least one marker gene controlled by a promoter of a gene, the transcription of said gene being significantly increased or reduced in the absence of nitrogen, phosphorus or sulphur, and the yeast cells are at least coupled to a signal detector. | 09-02-2010 |
| 20100227386 | COMPACT OPTICAL DETECTION SYSTEM - A detection system is provided, the detection system comprising a light source that generates excitation light having a wavelength sufficient to excite a fluorophore in a sample; an excitation filter positioned along a first line along a path of the excitation light, the excitation filter transmitting the excitation light from the light source; a beam splitter positioned along the first line, the beam splitter reflecting the excitation light transmitted by the excitation filter along a second line toward a mirror positioned on one side of the beam splitter, and passing emitted light reflected along the second line; the mirror, positioned to reflect the excitation light from the beam splitter to the fluorophore in the sample along a third line, normal to both the first and second lines, wherein the mirror further reflects emitted light emitted along the third line, along the second line toward the beam splitter; an emission filter positioned along the second line, on a second side of the beam splitter; and a detector that detects the emitted light transmitted by the emission filter. | 09-09-2010 |
| 20100248351 | CHIP FOR OPTICAL ANALYSIS - The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or a health affecting substance in a liquid to be measured. The chip for optical analysis of the present invention is characterized in that (1) an adsorption region (filter region) is provided between a sample introduction section and the observation section in a passage of the chip for analysis, (2) a bypass passage is provided in the passage (main passage) of the chip for analysis, and a time lag is generated between samples passed through the main passage and passed through a bypass passage, and (3) a measurement region and a reference region are provided in the observation section of the chip for analysis. In the present invention, the aspects (1) to (3) can be achieved individually or two or more thereof can be combined. | 09-30-2010 |
| 20100248352 | SENSOR FOR BIOLOGICAL DETECTION - Provided is a sensor for biological detection. The sensor for biological detection includes: a sensing unit including a light generator, an optical coupler, and an optical detector, the optical coupler dividing light incident from the light generator to project divided lights into a bio chip and a reference unit, respectively, and coupling the lights reflected from the respective bio chip and reference unit as one output light, and the optical detector detecting the output light, and the bio chip is independently separated from the sensing unit to be disposed on paths of lights divided by the optical coupler. The sensing unit has a composition of the Michelson interferometer. | 09-30-2010 |
| 20110003373 | ANALYTE TREATMENT APPARATUS - The present invention provides an analyte treatment apparatus that makes it easy to check various information about liquid chemicals stored in liquid chemical tanks made of resin from outside the liquid chemical tanks. | 01-06-2011 |
| 20110008879 | BIO-ASSAY SUBSTRATE, BIO-ASSAY APPARATUS, AND READING APPARATUS - A bioassay substrate high in integration amount, free in grouping of substances, low in cost, and the like are provided. Specifically, a bioassay substrate includes detection surfaces S on which detection substances can be solidified, the detection surfaces S is provided on a surface of a disk form substrate capable of reading out record information optically, and the detection surfaces S is provided in groove structures (pits) provided in the surface of the substrate radially as viewed on the upper side at predetermined intervals. A bioassay system using the bioassay substrate and a readout system are also provided. | 01-13-2011 |
| 20110008880 | Portable Analyzer - A portable analyzer A | 01-13-2011 |
| 20110033917 | SENSOR WITH LONG-TERM STABILITY FOR BIOPROCESSES - A sensor for registering a measured variable of a medium, especially in a bioprocess. The sensor includes a sensor body, wherein at least one surface section of the sensor body can be supplied with the medium, and wherein a condition of this surface section affects the measured value. The sensor is characterized by the fact that the surface section contains a substance with biocidal properties. | 02-10-2011 |
| 20110059521 | DEVICE AND METHOD FOR MONITORING INHIBITION OF PLATELET FUNCTION - The invention provides a method of monitoring the response of platelets to a cyclooxygenase-1 (COX1) inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX1 inhibitor; mixing the blood with a COX1-dependent platelet agonist, such as arachidonic acid, monitoring extracellular ATP in the agonist-activated blood to generate a measurement, and comparing the measurement to a standard value. Devices, systems, and kits for carrying out the method are also provided. | 03-10-2011 |
| 20110086418 | HIGHLY SENSITIVE OXYGEN SENSOR FOR CELL CULTURE - An oxygen sensor comprising an oxygen sensing compound and configured to substantially mitigate leaching of the oxygen sensing compound from the oxygen sensor to an outer surface thereof is provided. The oxygen sensor may comprise one or more layers. A first portion of the oxygen sensor is configured to be permeable to gas and comprises an oxygen sensing material. A second portion is disposed with or on the first portion and is configured to be permeable to gas and substantially impermeable to the oxygen sensing material. | 04-14-2011 |
| 20110195492 | Optical Apparatus - An optical apparatus for illuminating particles and for detecting emissions from illuminated particles in a flow cytometer having an optical configuration aligned with a flow or particles. | 08-11-2011 |
| 20110201100 | SINGLE USE CELL CULTURE BIOREACTOR MANIFOLD SYSTEM - The invention provides a disposable cell culture bioreactor manifold system for use in coupling sensors, fluid samplers, conduits, and the like, to a cell culture bioreactor in a sterile manner. The disposable bioreactor manifold system includes an externally attachable bioreactor manifold connector body for fluidly attaching modular sensor arrangements that measure physical variables and other parameters of medium contained within a bioreactor, as well as medium sampling components, and other connections, as well as at least one conduit fluidly connecting connecting the bioreactor manifold connector body with a pump for pumping fluids between the bioreactor and the bioreactor manifold connector body. | 08-18-2011 |
| 20110201101 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - Disclosed is a microfluidic structure and a microfluidic device comprising the microfluidic device, which is suitable for detecting a target material. The microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction. | 08-18-2011 |
| 20110212512 | MONITORING NETWORK BASED ON NANO-STRUCTURED SENSING DEVICES - A monitoring network system for inspecting and controlling harmful substances includes probe assemblies that each includes a sensor comprising nano structured surfaces or nano particles in a solution, configured to adsorb molecules of a sample material captured adjacent to the sensor, a laser that can emit a laser beam to illuminate the molecules adsorbed to the nano structured surfaces, a spectrometer that can produce spectral data from light scattered by the molecules adsorbed to the nano structured surfaces, and a ID reader that can retrieve identification information about the sample material. A central office can determine a spectral signature matching spectral signatures stored in a database and to identify a harmful substance in the sample material. An alert and response system can send out an alert signal about the sample material when the harmful substance is identified in the sample material. | 09-01-2011 |
| 20110223654 | NANO-MICROFLUIDIC APPARATUS FOR CONTINUOUS REAL-TIME ANALYSIS OF TARGETS IN THIN LIQUID FILMS - Nano-microfluidic devices and uses thereof are described. In particular, systems and methods are described for continuous real-time monitoring and analysis of targets in thin liquid films; such targets can include living cells and tissues. In some embodiments, nano-microfluidic devices can be utilized to observe living cells in layers of thin liquid media by IR-spectroscopy. | 09-15-2011 |
| 20110223655 | System for Measuring and Analyzing Properties of Water and Sediment Samples - A system for assessing the characteristics and toxicity of a water sample comprising: a test chamber; an optical signal generator configured to emit an optical signal into the test chamber; a first digital filter disposed between the optical signal generator and the test chamber; a first optical transducer disposed to generate a first data signal in response to detecting radiant energy in the test chamber; a second digital filter disposed between the first optical transducer and the test chamber; an aqueous suspension of dinoflagellates contained within the test chamber and mixed with the water sample; a stimulator disposed to stimulate the dinoflagellates to emit a bioluminescence signal; and a microprocessor operatively coupled to the optical signal generator, the first digital optical filter, the stimulator, the first optical transducer, and the second digital filter, wherein the microprocessor is configured to assess the spectral characteristics and toxicity of the water sample. | 09-15-2011 |
| 20110263008 | Cell Culture Real-Time Observation System - The present invention discloses a cell culture realtime observation system comprising a plate, a culture well, an image capture device, at least one container, an evaporation device, a first micro channel, a second micro channel and a transmission unit. The culture well is disposed on the plate, and the image capture device is disposed between the plate and the culture well. The container is disposed on the plate and at a side of the culture well, and the evaporation device is disposed at the other side of the culture well. The container and the culture well are connected by the first micro channel, and the culture well and the evaporation device are connected by the second micro channel. The transmission unit is electrically connected to the image capture device. | 10-27-2011 |
| 20110287530 | APPARATUS TO CHARACTERIZE BLOOD AND RED BLOOD CELLS VIA ERYTHROCYTE MEMBRANE FRAGILITY QUANTIFICATION - The present disclosure describes an apparatus for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. The apparatus for quantifying the quality degradation of individual stored (RBC) units comprises: a hemolysis unit; an optical analysis unit; and a computation unit. This apparatus is amenable to clinical implementation as well as indicative of any given unit's relative viability and thus prospective efficacy. This would provide clinicians with actual data on RBC quality when making decisions about which and how many units to use for transfusion of a given patient. Moreover, deploying this testing throughout the supply chain will improve distribution, planning, and inventory control decisions. A vital aspect of this testing system is the accumulation of copious output and other associated data and the mathematical analyses thereof to optimize algorithms by which to characterize each subsequent test output as meaningfully as possible. While the present invention is directed toward applications in blood quality control, the core technology of “quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis” could have broader application, such as in disease diagnosis. | 11-24-2011 |
| 20110318822 | ANALYTICAL STRIP - This invention discloses an analytical strip comprising a substrate. The substrate has a channel provided concavely on the upper surface thereof. The channel comprises a first area for receiving a fluid sample, a second area for delivering the fluid sample, and a third area where the fluid sample reacts. These three areas are connected sequentially. Nitrocellulose layers are formed at the bottoms of both the second area and the third area. Each of the nitrocellulose layers comprises a hollow-matrix conformation. In addition, the nitrocellulose layer of the second area has an average thickness that is not greater than that of the nitrocellulose layer of the third area. The strip also comprises a reaction material formed in the hollow-matrix conformation of each of the nitrocellulose layers. | 12-29-2011 |
| 20120003728 | Scalable Portable Sensory and Yield Expert System for BioMass Monitoring and Production - The invention relates to the field of algae biofuel production, in particular to methods and means of physical action on biological structures of photosynthesing microorganisms, phototrophic algae in particular. The invention can be used for obtaining biofuel from algae, as well as for the pharmaceutical, cosmetic and foodstuff industries. In the process of the method implementation radiation of cultivated solution of photosynthesizing microorganisms/phototrophical algae is carried out by the action of electromagnetic waves of a selected intensity. Stimulation of increasing photosynthesizing microorganisms/phototrophical algae biomass is obtained by the interaction of electromagnetic wave and biological cell. Irradiation of cultivated solution of photosynthesizing microorganisms/phototrophical algae is performed by electromagnetic waves originating from specified sensor mechanisms mounted about the acrylic or plastic-based stackable tubular bioreactor. Nutrients, carbon dioxide and other dissolved substances are monitored by this sensor system which is controlled by a supercomputer-based control mechanism. | 01-05-2012 |
| 20120003729 | CAPILLARY PERFUSED BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel. | 01-05-2012 |
| 20120003730 | PORTABLE SAMPLE ANALYZER CARTRIDGE - A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training. | 01-05-2012 |
| 20120003731 | ANALYZER AND METHOD FOR WASHING DISPENSER PROBE - The analyzer ( | 01-05-2012 |
| 20120009667 | APPARATUS AND METHOD FOR ANALYZING FLUID SAMPLE - The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample. | 01-12-2012 |
| 20120045826 | KITS AND DEVICES FOR DETECTING ANALYTES - The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests. | 02-23-2012 |
| 20120064615 | TEST ELEMENT FOR DETECTING AN ANALYTE IN A SAMPLE - The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap. | 03-15-2012 |
| 20120064616 | DEVICE FOR MEASURING AN ULTRA LOW GAS FLOW - A measuring device is disclosed for measuring an ultra low gas flow, working by the principle of liquid displacement. In at least one embodiment, the measuring device includes at least one cell including a gas inflow device, a gas compartment device with a predefined inner geometric physical volume and active volume. In at least one embodiment, the gas compartment device includes one gas accumulating end and one lifting end, the gas compartment device also defining a geometric gas collecting point inside of the gas compartment device, during a gas filling cycle, the geometric gas collecting point moving further and further from the gas accumulating end to the lifting end during the gas filling cycle. Further, in at least one embodiment the cell includes a holding device having a pivoting element enabling the gas compartment device to pivot upwards when the geometric gas collecting point is positioned at the lifting end and the lifting force is larger than the down-pressing force at the lifting end, thereby releasing all of the accumulated gas in the gas compartment device, and then pivoting back to its initial standby position for new receipt and storage of gas during another gas filling cycle until next releasing sequence. Finally, in at least one embodiment, the cell also includes a sensor provided to generate a signal and/or change the state of a signal when the gas compartment device is not in its initial standby position, wherein the gas storing capacity of the inside of the gas compartment device is larger at the gas accumulating end than at the lifting end and wherein the gas accumulating end has a higher vertical position than the lifting end at the initial standby position. | 03-15-2012 |
| 20120070885 | INTEGRATED DEVICE FOR ANALYZING AQUEOUS SAMPLES USING LIPID MULTILAYER GRATINGS - Described is a device comprising lipid multilayer gratings. | 03-22-2012 |
| 20120070886 | MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE - A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS). The microfluidic device is manufactured using a gas expansion molding (GEM) technique. | 03-22-2012 |
| 20120088295 | DEVICE FOR CONCENTRATING AND SEPARATING CELLS - Provided is a device for concentrating and separating cells, which has a function for continuously concentrating cells; a function for then continuously arranging the concentrated cells in predetermined regions of a flow path; a function for simultaneously identifying shape and fluorescent emission in one-cell units on the basis of cell concentration and purification images, which serve to continuously separate and purify cells that have different properties in that they are either attracted to or repelled by an induction electrophoresis force of a predetermined frequency; and a function for identifying cells on the basis of this shape and fluorescent emission information and thereby separating and purifying the cells. | 04-12-2012 |
| 20120094370 | BLOOD GLUCOSE TEST INSTRUMENT KIT HAVING MODULAR COMPONENT PARTS - A blood glucose test instrument kit having modular component parts capable of being assembled into a plurality of different handheld blood glucose test instruments is disclosed. The kit comprises the combination of an interconnection platform adapted to connect to a collection of interoperable modules. The collection of interoperable modules including: a plurality of different measurement engine modules, at least one user interface module, at least one power supply module. A handheld blood glucose test instrument is assembled by the interconnection to the interconnection platform of at least one measurement engine module, at least one user interface module, and at least one power supply module. The inter-module communication among the modules connected thereto to achieve enhanced glucose test instrument reliability by effecting at least one reliability protocol selected from a group of reliability protocols. | 04-19-2012 |
| 20120094371 | TEST STRIP FOR H. PYLORI DETECTION - A test device, including: a compartment defining an environment and comprising a specimen region; an indicator medium disposed in the compartment; a separation medium disposed in the compartment between the specimen region and the indicator medium; an active ingredient adjacent the specimen region; and a color indicator disposed on the indicator medium and responsive a chemical compound produced by a reaction involving the active ingredient by changing from a first color to a second color. The separation medium is configured to permit fluid communication directly between the environment and a side of the indicator medium proximate the separation medium when the separation medium and the indicator medium abut each other. | 04-19-2012 |
| 20120115215 | LIGHT SOURCE REFLECTOR - A light source reflector includes a structure having three or more internal reflective surfaces defining a first light entry aperture and a second light exit aperture having an area that is greater than the area of the entry aperture. A single light source, or a plurality of uniformly distributed light sources, such as one or more LEDs, located proximal the entry aperture provides illumination, which impinges on the reflective surfaces from the entry aperture and is reflected off the surfaces to provides a substantially uniform illumination pattern exiting the exit aperture. The reflector advantageously allows for the use of a source (e.g., LED(s)) that is smaller than the targeted area of illumination and also avoids creating hot-spots as the reflector does not focus the light, but rather reflects mirror images of the source off of the reflective surfaces. | 05-10-2012 |
| 20120115216 | CONTAINER FOR TESTING FOR MICRO-ORGANISMS - A multi-compartment resealable container for testing for the presence of micro-organisms is provided with or adapted to receive a sample in a first substantially rigid transparent compartment, a growth medium in a second compartment, and a sanitizer in a third compartment, the compartments being separated by foil seals, the second and third compartments have an associated plunger which when depressed causes serrated cutters to puncture the foil seal and allow the contents to be added to the liquid containing or comprising the sample. | 05-10-2012 |
| 20120142086 | IMAGING SYSTEM COMPRISING MICROLENSES AND ASSOCIATED DEVICE FOR DETECTING A SAMPLE - The invention relates to an imaging system and an associated device for detecting a sample ( | 06-07-2012 |
| 20120149094 | Biological Sterilization Indicator and Method of Using Same - A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions. | 06-14-2012 |
| 20120164718 | Removable/disposable apparatus for MEMS particle sorting device - A micromechanical particle sorting system uses a removable/disposable apparatus which may include a compressible device, a filter apparatus and a cell sorter chip assembly. The chip assembly may include a tubing strain relief manifold and a microfabricated cell sorting chip. The chip assembly may be detachable from the filter apparatus in order to mount the MEMS particle sorting chip adjacent to a force-generating apparatus which resides with the particle sorting system. A disturbance device installed in the particle sorting system may interact with a transducer on the removable/disposable apparatus to reduce clogging of the flow through the system. Using this removable/disposable apparatus, when the sample is changed, the entire apparatus can be thrown away with minimal expense and system down time. | 06-28-2012 |
| 20120164719 | METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING - A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values. | 06-28-2012 |
| 20120178152 | MEDICAL HAND-HELD DEVICE - A medical hand-held device is disclosed comprising a test tape unit that can be inserted into a device housing which comprises a test tape provided with a plurality of analytical test elements which can be wound by means of a spool, and a tape drive comprising an electric motor and a gear unit that can be coupled to the test tape unit for winding the test tape forwards in sections, such that the test elements can successively be provided for sample application. The axis of rotation of the electric motor is arranged in a plane extending transversely to the axis of rotation of the spool and that the gear unit has an angle drive to change the direction of the axis. | 07-12-2012 |
| 20120190104 | MEMS Particle sorting actuator and method of manufacturing - A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid. | 07-26-2012 |
| 20120190105 | Cartridge for MEMS particle sorting system - A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described. | 07-26-2012 |
| 20120196356 | COMBINED INSPECTION SYSTEM INCLUDING MID-IR VIBRATIONAL SPECTROSCOPY AND A FLUORESCENT CYTOMETRY FACILITY - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source configured to deliver light to a cell within the cells in order to induce resonant mid-infrared absorption by one or more analytes of the cell. The system includes a laser source that excites at least one fluorophore present in the cell or on the surface of the cell and a fluorescence detector that measures the fluorescence intensity of the fluorophore. A mid-infrared detection facility detects the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light and the fluorescence intensity are used to identify at least one cell characteristic. | 08-02-2012 |
| 20120202277 | MINIMALLY INVASIVE CYTOMETRY SYSTEM WITH QCL INSPECTION OF SINGLE CELLS FOR CANCER DETECTION - This disclosure concerns a minimally invasive cytometry system including a handling system that presents single cells to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The cytometry system also includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either cancerous or non-cancerous. | 08-09-2012 |
| 20120202278 | SYSTEM AND METHOD FOR REPEAT MEASUREMENT OF SINGLE CELLS USING VIBRATIONAL SPECTROSCOPY - This disclosure concerns a high-throughput cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light successively to single cells over a time period in order to make successive measurements of induced resonant mid-infrared absorption by one or more analytes of the cells. The cytometry system also includes a mid-infrared detection facility that detects the successively transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify a changing cell characteristic over the time period. | 08-09-2012 |
| 20120208264 | METHOD AND APPARATUS FOR DETECTION OF LIVIGN PHYTOPLANKTON CELLS IN WATER - The invention relates to a method and an apparatus for detecting living phytoplankton cells and/or microorganisms in or out of water, particularly ballast water, bodies of water, sewage, or water in swimming and bathing devices. Said method is characterized by the following steps: the variable fluorescence (Fv) is calculated by forming the difference between the maximum fluorescence (Fm) and the minimum fluorescence (Fo) in a measuring space or detecting part or all of the dynamic shape of a fluorescence induction curve in a measuring space, particularly measuring; and calculating the number of living phytoplankton cells and/or microorganisms of a reference species in the measuring space in accordance with the variable fluorescence (Fv). | 08-16-2012 |
| 20120214225 | CELL INCUBATOR AND INCUBATION CONDITION MONITORING SYSTEM - A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a signal that is wirelessly transmitted from the communicating apparatus. | 08-23-2012 |
| 20120225474 | SYSTEM AND METHOD FOR PATHOGEN DETECTION AND IDENTIFICATION - This disclosure concerns a pathogen inspection system that includes a handling system that presents single cells from a sample to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The system includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either a pathogen or not a pathogen. | 09-06-2012 |
| 20120225475 | CYTOMETRY SYSTEM WITH QUANTUM CASCADE LASER SOURCE, ACOUSTIC DETECTOR, AND MICRO-FLUIDIC CELL HANDLING SYSTEM CONFIGURED FOR INSPECTION OF INDIVIDUAL CELLS - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce resonant mid-IR vibrational absorption by one or more analytes, leading to local heating that results in thermal expansion and an associated shockwave. An acoustic detection facility that detects the shockwave emitted by the single cell. | 09-06-2012 |
| 20120231534 | Spectrometric device - The present invention provides improved spectrometric devices useful for measuring optical quantities of a component, including a solid state LED emitter, having at least one wavelength that is matched to the wavelength that is useful for the spectral analysis of the component of interest, a photodetection cell and an optimizing configuration and permits control of the LED emitter and the detector sensitivity to provide a range of detection for the signals corresponding to the optical density of a sample being analyzed and that affords sensitivity for a desired component of a sample by minimizing the error associated with electronic components and signals. Preferred embodiments also include configurations for determining an anticoagulant therapy value that may be used to determine treatment for a patient. | 09-13-2012 |
| 20120238008 | Rapid Detection of Pathogens Using Paper Devices - A kit for the rapid detection of pathogens in food supplies. The kit includes a microspot device and one or more indicator reagents to be applied to a well of the microspot device. The employed indicator reagent produces a detectable change upon contact with a pathogen of interest. The microspot device is fabricated from a porous membrane, such as filter paper. A substantially continuous boundary composed of a low melting temperature solid is deposited within the porous membrane extending from the top of the membrane to the bottom of the membrane and defines the peripheral sides of the well. Additionally, a barrier is applied to the bottom of the membrane, thus defining the bottom of the well. The kit can further include growth media for enriching the pathogenic bacteria and instructions for use of the kit employing the microspot device and the one or more indicator reagents. | 09-20-2012 |
| 20120238009 | BIOSENSOR METHOD AND SYSTEM BASED ON FEATURE VECTOR EXTRACTION - A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal. | 09-20-2012 |
| 20120244608 | Composite sensor assemblies for single use bioreactors - A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:
| 09-27-2012 |
| 20120244609 | Composite sensor assemblies for single use bioreactors - A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:
| 09-27-2012 |
| 20120244610 | PHOTO-DAMAGE APPARATUS FOR SORTING PARTICLES - A system and apparatus for sorting a mixture of stained particles in a fluid flow path, including stained particles. The system can include a pulsed electromagnetic radiation source for exciting fluorescence emissions from the stained particles, a photodetector for detecting the fluorescence emissions from the stained particles, a processor for classifying the stained particles; and a photo-damaging laser for damaging selected particles in the flow path. | 09-27-2012 |
| 20120252111 | MEASURING SYSTEM USING OPTICAL WAVEGUIDE, MEASURING DEVICE, MEASURING METHOD, OPTICAL WAVEGUIDE TYPE SENSOR CHIP, AND MAGNETIC FINE PARTICLE - According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide. | 10-04-2012 |
| 20120264204 | Method and apparatus using optical techniques to measure analyte levels - A device is provided for use with a tissue penetrating system and/or a metering device for measuring analyte levels. The device comprises a cartridge and a plurality of analyte detecting members mounted on the cartridge. The cartridge may have a radial disc shape. The cartridge may also be sized to fit within the metering device. The analyte detecting members may be optical system using fluorescence lifetime to determine analyte levels. In one embodiment, the device may also include a fluid spreader positioned over at least a portion of the analyte detecting member to urge fluid toward one of the detecting members. A plurality of analyte detecting members may be used. Each analyte detecting member may be a low volume device. | 10-18-2012 |
| 20120288926 | Blood Cell Trajectory Displaying Device - Disclosed is a blood cell trajectory display device ( | 11-15-2012 |
| 20120309080 | Surface Enhanced Raman Spectroscopy Nanodome Biosensors and Methods of Manufacturing the Same - Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring. | 12-06-2012 |
| 20120309081 | SYSTEM AND PLANT FOR CULTIVATION OF AQUATIC ORGANISMS - Provided are a cultivating system for cultivating aquatic organisms including a load-bearing structure having a top portion with at least two top rims transverse to each other and defining a top portion, a bottom portion, and flexible tank adapted for receiving therein a growing medium and for cultivating therein aquatic organisms. Further, the tank can include at least two sidewalls extending such that at least in one cross-section taken along a plane perpendicular to said top portion, at least two of the sidewalls form a general V-shape converging towards the bottom portion. The system can also include a gas emitting arrangement linkable to a source of pressurized gas and comprising gas emitting nozzles disposed within the flexible tank at the bottom portion. | 12-06-2012 |
| 20130023042 | METAL BUFFER LAYER ASSISTED GUIDED MODE RESONANCE BIOSENSOR - A metal buffer layer assisted guided mode resonance (GMR) biosensor is disclosed. The GMR biosensor includes a substrate, a metal buffer layer and a waveguide layer. The metal buffer layer is disposed on the substrate and the waveguide layer is disposed on the metal buffer layer. The metal buffer layer, which is disposed adjacent to the waveguide layer, can carry out the total reflection and provide extra phase compensation of the total reflection at the same time. Accordingly, the propagation constant of the resonance wave would be much closer to the sensitivity of the phase, and the resonance electric field of the GMR biosensor would be much closer to the sensitive area. Consequently, the sensitivity of the GMR biosensor could be improved. | 01-24-2013 |
| 20130045529 | Method, System, and Compositions for Cell Counting and Analysis - The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label. | 02-21-2013 |
| 20130102065 | Small Volume and Fast Acting Optical Analyte Sensor - A fast acting sensor designed to accommodate an aqueous analyte-containing sample having a volume of less than one microliter and that can be used to quantify the amount and concentration of such analyte in the sample through light reflectance or fiber-optic light reflectance. The sensor includes a storage chamber, a capillary passage, and a reaction membrane. The storage chamber acts to collect the sample and to secure such sample while it undergoes detection. The capillary passage acts to direct the sample over the reaction membrane and controls the diffusion of the sample in the storage chamber. The reaction membrane contains all of the chemicals and enzymes needed to cause a color-change reaction when contacted with the sample. The amount of analyte can be determined by light reflectance intensity with an optical measurement instrument. | 04-25-2013 |
| 20130102066 | CHALCOGENIDE-FIBRE, INFRARED EVANESCENT WAVE SENSOR AND PROCESS FOR PRODUCING SAME - The invention relates to a fibre sensor that enables the propagation of infrared light at at least one wavelength of 0.8 to 25 micrometres, the fibre successively comprising along its length a first infrared waveguide section ( | 04-25-2013 |
| 20130102067 | CELL MONITORING BY MEANS OF SCATTERED LIGHT MEASUREMENT - A device for monitoring test cells has at least one receiving unit for the test cells and a first measuring unit for cell measurement. With a second measuring unit, which has a light source and a scattered light detector, cell monitoring can be carried out during the cell measurement. For this purpose the receiving unit has an at least partially light-permeable substrate and is arranged between the light source and scattered light detector such that at least a part of the light generated by the light source shines on the receiving unit, is scattered on the test cells and, after leaving the receiving unit through the substrate, impinges on the scattered light detector. | 04-25-2013 |
| 20130109083 | DEVICE AND SYSTEM FOR COUNTING AND ANALYSING PARTICLES AND USE OF SAID SYSTEM | 05-02-2013 |
| 20130122578 | Fungus Diagnostic Detention Device - A fungus diagnostic device for detecting the presence of a fungus includes a testing container having an open top and defining an interior area configured to receive a protein formulated to promote fungus growth. The diagnostic device includes an invertible cap removably coupled to the container open top. A plunger is mounted to a top side of the cap. | 05-16-2013 |
| 20130130368 | INTEGRATED MICROBIAL COLLECTOR - A system for real-time sizing of fluid-borne particles is disclosed. The system further determines, in real time, whether the detected particles are biological or non-biological. As the fluid is being tested, it is exposed to a microbe collection filter which is cultured to determine the type of microbes present in the fluid being tested. | 05-23-2013 |
| 20130137167 | MICROWAVE TRIGGER METAL-ENHANCED CHEMILUMINESCENCE (MT MEC) AND SPATIAL AND TEMPORAL CONTROL OF SAME - The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave energy and further enhanced by using metallic geometric structures for spatially and temporally controlling the biological and chemical reactions. | 05-30-2013 |
| 20130143312 | DROPLET-BASED CELL CULTURE AND CELL ASSAYS USING DIGITAL MICROFLUIDICS - We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is suitable for assaying and culturing both cells in suspension and cells grown on surface (adherent cells). This method is advantageous for cell culture and assays due to the automated manipulation of multiple reagents in addition to reduced reagent use and analysis time. No adverse effects of actuation by DMF were observed in assays for cell viability, proliferation, and biochemistry. These results suggest that DMF has great potential as a simple yet versatile analytical tool for implementing cell-based assays and cell culture on the microscale. | 06-06-2013 |
| 20130149776 | Assay Devices and Methods - A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor. | 06-13-2013 |
| 20130157350 | APPARATUS AND METHOD FOR DETECTING GLYCOL - A method and apparatus are provided for detecting contaminants, such as ethylene glycol and diethylene glycol, in various materials, including household products, and medicines. The contaminants can be detected using enzyme assays that produce measurable changes in light absorption and/or light fluorescence. | 06-20-2013 |
| 20130157351 | COMPACT WIDE-FIELD FLUORESCENT IMAGING ON A MOBILE DEVICE - Wide-field fluorescent imaging on a mobile device having a camera is accomplished with a compact, light-weight and inexpensive optical components that are mechanically secured to the mobile device in a removable housing. Battery powered light-emitting diodes (LEDs) contained in the housing pump the sample of interest from the side using butt-coupling, where the pump light is guided within the sample holder to uniformly excite the specimen. The fluorescent emission from the sample is then imaged using an additional lens that is positioned adjacent to the existing lens of the mobile device. A color filter is sufficient to create the dark-field background required for fluorescent imaging, without the need for expensive thin-film interference filters. | 06-20-2013 |
| 20130164830 | Combination Assay Device and Method for Detecting Compounds in Vaginal Fluid - A combination assay device and method for simultaneously detecting the presence of hydrogen peroxide and D-lactic acid in vaginal fluid. The methods for detecting the hydrogen peroxide and the D-lactic acid are colorimetric-based. The device includes a pair of laminar flow substrates each having a solid-state compound for the detection of hydrogen peroxide and D-lactic acid disposed thereon. The solid-state format provides ease of use and storage. | 06-27-2013 |
| 20130177972 | BIOREACTORS, SYSTEMS, AND METHODS FOR PRODUCING AND/OR ANALYZING ORGANS - Articles and methods for growing or analyzing tissues and organs using bioreactors or other devices and components are provided. In some embodiments, a bioreactor is configured to provide a growth chamber having one or more inlets, outlets, sensors, organ attachment sites, and/or organ identifiers. | 07-11-2013 |
| 20130177973 | Flow Cytometer - A flow cytometer for a microanalysis and a fast detection is provided. In the flow cytometer, the downstream portion of a flow cell is fitted with an optical detection system including a laser emitter and a light detector, an imaging system including a high-speed camera and a stroboscopic lamp, and a cell sorter. The high-speed camera and the stroboscopic lamp illuminates and photographs candidate particles based on a photographing trigger signal provided by a trigger generator. The trigger signal is provided by the trigger generator when a predetermined time has elapsed from the moment when an examination particle determined to be a candidate particle has been measured by the optical detection system. The high-speed camera photographs multiple images for a given period of time from the moment when the trigger signal is provided, and sends the image data to a target particle detection unit of a data processor. | 07-11-2013 |
| 20130177974 | Accelerated Wright-Giemsa and May-Grunwald Staining Methods - The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grúnwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grúnwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures. | 07-11-2013 |
| 20130210130 | AUTOMATED CELL CULTURE SYSTEM - The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module. | 08-15-2013 |
| 20130217108 | ENHANCED SCHEDULING SAMPLE PROCESSING SYSTEM AND METHODS OF BIOLOGICAL SLIDE PROCESSING - A sample processing system | 08-22-2013 |
| 20130217109 | Apparatus for Embedding Tissue Samples - A histology tissue embedding apparatus including a reservoir for an embedding medium and an outlet valve connected to the reservoir through which the embedding medium is dispensable, and including trigger means which control the operation of the outlet valve, the trigger means having a rest position in which the outlet valve is closed, wherein the rest position of the trigger means in relation to the outlet valve is adjustable. | 08-22-2013 |
| 20130217110 | CELL ANALYZER, CELL PROCESSING APPARATUS, SPECIMEN PREPARING APPARATUS - The present invention provides a cell analyzer which comprises: a cell dispersion unit which causes aggregated cells in a biological specimen to be dispersed, through a shearing force applying process of applying a shearing force to the aggregated cells and an ultrasonic dispersion process of dispersing the aggregated cells, by using ultrasonic waves; a detection unit which detects characteristics information reflecting properties of the cells in the biological specimen on which the shearing force applying process and the ultrasonic dispersion process have been performed; and an analysis unit which analyzes the cells in the biological specimen, based on a detection result from the detection unit. | 08-22-2013 |
| 20130224850 | Device and method for detecting bacterial endospores that are suspended in the atmosphere - A device that detects bacterial endospores suspended in the atmosphere is provided. The device having an aerosol concentrator, a collection vessel containing a lanthanide salt solution, an excitation energy source and an optical set-up that directs the excitation energy source to the lanthanide salt solution and collects photoluminescence generated by the lanthanide salt solution upon receipt of the excitation energy source. A system and method for detecting bacterial endospores is also disclosed. | 08-29-2013 |
| 20130224851 | SYSTEM, APPARATUSES AND DEVICES FOR PRETREATING CELLS - The present invention provides a system and apparatuses/devices capable of automatically performing the processes of cell treatment preparatory to flow cytometry and similar cytological studies in a fully automated and streamlined manner. The system and apparatuses/devices are being adapted for preparation and (pre)processing of cell samples, e.g. blood and/or bone marrow samples. | 08-29-2013 |
| 20130230911 | POROUS STRUCTURE WITH INDEPENDENTLY CONTROLLED SURFACE PATTERNS - Disclosed herein are systems and methods for manufacturing and using a cell culture support device. The device includes a plurality of polymer layers, each with at least one flow chamber defined therethrough. The device also includes a cross channel interface between the channels of different polymer layers. The cross channel interface includes a plurality of pores and a topographical pattern that is selected independent of the plurality of pores. Furthermore, the formation of the topographical pattern preservers the pores. | 09-05-2013 |
| 20130230912 | BASE BODY AND METHOD FOR MANUFACTURING BASE BODY - A base body includes: a base member; a channel provided in the base member, the channel having an inner wall surface and flowing a fluid; a fine vacuum hole provided in the inner wall, the fine vacuum hole causing the channel to communicate the outside of the base member other and having an opening; and a slow flow portion disposed at a position close to the opening of the fine vacuum hole in the inner wall surface, the slow flow portion slows a flow of the fluid, wherein at least a portion that configures the fine vacuum hole in the base member is formed of a single member. | 09-05-2013 |
| 20130230913 | MAGNETIC PARTICLE BASED BIOSENSOR - A biosensor system and method of its use for detecting particles on the surface of an integrated circuit is disclosed. The system can include a light source and a plurality of optical sensors formed on an integrate circuit. The particles can be positioned the surface of the integrated circuit whereby the particles can cast a shadow or shadows that reduces the amount of light transmitted from the light source to the optical sensors. The surface of the integrated circuit can include one or more optical sensing areas whereby the presence of one or more particles may significantly or measurably reduce the amount of light incident on one or more optical sensor. | 09-05-2013 |
| 20130244317 | Flow Cytometer Sorter - Disclosed are computer-implemented methods of sorting particles from a particle stream in a flow cytometer. The methods include: calculating sort decision making parameters using the raw event data values from a flow cytometer and a sort logic; performing sort logic computations using the sort logic definition and the sort decision making parameters to generate sort decisions; converting the sort decisions into sort commands; and sending the one or more sort commands to the flow cytometer. Sort logic computations may include algorithmically using conditional branching logic, and may include sort logic equations having mathematical functions characterizing one or more regions of interest in multidimensional data space. Such mathematical functions may be determined based on one or more parameters provided by a user. Also disclosed are corresponding systems having a flow cytometer and a computer. | 09-19-2013 |
| 20130244318 | Automated Transient Image Cytometry - A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity. | 09-19-2013 |
| 20130252322 | DRY CHEMISTRY, LATERAL FLOW-RECONSTITUTED CHROMATOGRAPHIC ENZYME-DRIVEN ASSAYS - A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desired reaction, are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final “read zone” wherein the color developed is read against predetermined color standards for the desired reaction. Pretreatment pads for the sample, as needed, are placed in front of the sample pad in the flow path as appropriate. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays. | 09-26-2013 |
| 20130260448 | SYSTEMS AND METHODS FOR DETECTING FALLEN CONTAINERS SUITABLE FOR APPARATUS FOR AUTOMATED EVALUATION OF MICROORGANISM GROWTH IN TEST SAMPLES - Methods, systems, computer program products, apparatus and circuits are configured to detect fallen containers upstream or proximate an intake zone suitable for automated evaluation apparatus using different sensors, including at least one lower sensor and at least one upper sensor which is positioned to project an optical signal at a height corresponding to a top portion of an upright container to thereby allow an increased reliability in detection of different orientations and positions of fallen containers. An optional second lower sensor may be used which is longitudinally spaced apart from the first lower sensor and the lower sensors can transmit optical signals across the container travel path that do not intersect. | 10-03-2013 |
| 20130267017 | Portable Coagulation Monitoring Device for Assessing Coagulation Response - A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs between the two parallel planar surfaces. Detection of the coagulation response can be achieved through optical probing or by measurement of physical effects of the blood sample binding to the planar surfaces, and restricting movement thereof. | 10-10-2013 |
| 20130280797 | MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING - A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein. | 10-24-2013 |
| 20130280798 | DISTANCE MEASUREMENT SYSTEM AND OPTICAL RESOLUTION IMPROVEMENT APPARATUS - A distance measurement system includes: an irradiating means for irradiating two coherent electromagnetic waves having frequencies different from each other to an object under measurement in a partially displacing manner while having a same area; an electromagnetic wave detecting means for detecting electromagnetic waves from at least two or more areas on the object under measurement with a boundary line being interposed therebetween to extend in a direction substantially perpendicular to the displacement direction; a signal generating means for generating a difference signal or a summation signal of respective outputs of the electromagnetic waves detected in the electromagnetic wave detecting means at symmetrical positions with respect to the boundary line; and a measuring means for obtaining a phase difference or intensity difference of the difference signal or summation signal to obtain measurement values. | 10-24-2013 |
| 20130280799 | METHOD FOR THE EFFECTIVE DELIVERY OF PHOTONIC ENERGY TO CULTURES IN A FLUID MEDIUM - A method of preventing bio-filming during the delivery of photonic energy to a culture or set of organisms in a fluid culture medium, the method including introducing a fluid energy-transfer medium into the fluid culture medium through an interface; and distributing light into the fluid energy-transfer medium as it is introduced into the fluid culture medium. | 10-24-2013 |
| 20130288357 | WAVEGUIDE GRATING STRUCTURE AND OPTICAL MEASUREMENT ARRANGEMENT - The present invention describes (bio)chemo-functional waveguide grating structures consisting of at least one (bio)chemo-functional waveguide grating structure unit or at least one (bio)chemo-functional sensor location with beam guidance permitting light beam separation, as well as detection methods for parallel analysis which are marking-free or based on marking. | 10-31-2013 |
| 20130316443 | SYSTEM FOR DETECTING MICROORGANISMS - A system for detecting microorganisms in a test sample is provided that includes a fluorescently detectable product having both acidic and basic species, wherein the fluorescently detectable product is the reaction product of (a) an enzyme substrate that comprises an enzymatically hydrolysable group and a fluorescent group and (b) a test sample comprising a microorganism having an enzyme that hydrolyzes the hydrolysable group from the fluorescent group of the enzyme substrate. The fluorescently detectable product has an excitation isosbestic point Exλiso where the absorbance of the acid species is the same as the absorbance of the basic species. The system also includes a first light source having a wavelength of Exλiso for irradiating the fluorescently detectable product, The fluorescently detectable product emits light at a wavelength of Emλ1, and the quantity of light emitted at the wavelength Emλ1 is substantially constant across a pH range of 2.5 to 8.0. | 11-28-2013 |
| 20130316444 | APPARATUS FOR ANALYZING PARTICLES IN URINE AND METHOD THEREOF - An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed. | 11-28-2013 |
| 20130330816 | Apparatus and Methods for Controlling Cellular Development - According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | 12-12-2013 |
| 20130330817 | SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS - Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses. | 12-12-2013 |
| 20130337552 | FERMENTATION APPARATUS THAT USES BIOMASS AS FEEDSTOCK - There is provided an apparatus for treating a biomass feedstock at a high temperature, including: a cooling means for cooling a biomass liquid treated at a high temperature; an enzymatic saccharification tank for subjecting a cooled treated liquid to saccharification with an enzyme; a solid-liquid separation apparatus for removing water-slightly soluble fermentation inhibitory substances contained in the saccharide solution taken out from the enzymatic saccharification tank and a foreign substance removing unit provided with a microfiltlation (MF) membrane | 12-19-2013 |
| 20130344580 | ASSISTANT DEVICE FOR PIPETTING - An assistant device for pipetting is disclosed. The assistant device for pipetting comprises: a multi-well plate, a first light emitting element array, a first photo detector array, a second light emitting element array, a second photo detector array, a control circuit, and a display. The multi-well plate comprises a plurality of wells for containing a solution, and the plurality of wells are disposed as an array. The first and second light emitting element arrays are disposed at adjacent sides of the multi-well plate. The first and second photo detector arrays are disposed at the side opposite to the first and second light emitting element arrays respectively. The control circuit is connected to the light emitting element arrays, the photo detector arrays, and the display to determine the amount of pipetting times of each of the wells and display on the display. | 12-26-2013 |
| 20130344581 | ASSAY DEVICE AND METHODS - The present invention relates to the use of amphipathic polymers to enhance lateral flow and reagent mixing on assay devices. More specifically, the invention relates to use of an amphipathic polymer in assay methods including a device for determining the concentration of lipids in blood serum or plasma. | 12-26-2013 |
| 20130344582 | METHOD FOR ASSAYING CELL MOVEMENT - The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific binding of an analyte to a substrate by using a liquid crystal assay format. | 12-26-2013 |
| 20130344583 | BIOSENSOR COMPRISING AN OXIDASE ENZYME AND A HYDROGEN PEROXIDE INDICATOR MEANS - A biosensor for detecting the concentration of an analyte in wound fluid, the biosensor being at least substantially free of catalase and comprising a sensing means comprising an oxidase enzyme and a hydrogen peroxide indicator means, the arrangement being such that, when a sample of wound fluid comprising the analyte is brought into contact with the sensing means, the oxidase enzyme reacts with the analyte to produce hydrogen peroxide which triggers the indicator means to indicate the presence of the analyte in the wound fluid. | 12-26-2013 |
| 20130344584 | NON-INVASIVE BIOREACTOR MONITORING - A pair or receptacles capable of housing an emitter probe and a detector probe installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media. | 12-26-2013 |
| 20140017775 | ANALYTICAL INSTRUMENT FOR EVALUATING MICROBIAL CONTAMINATION OF AN OBJECT - An instrument for ascertaining a viable aerobic microbe count at t | 01-16-2014 |
| 20140024107 | COMPACT AUTOMATED CELL COUNTER - Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm | 01-23-2014 |
| 20140030800 | Methods and compositions for a multipurpose, lab-on-chip device - Methods and compositions for developing a series of microfluidic, USB-enabled, wireless-enabled, lab-on-chip devices, designed to reduce the chain-of-custody handling of samples between sample acquisition and final reporting of data, to a single individual. These devices provide on-the-spot testing for micro- and nanoscale (molecular) analysis of blood, urine, infectious agents, toxins, measurement of therapeutic drug levels, purity-of-sample testing and presence of contaminants (toxic and non-toxic, volatile and non-volatile); and for the identification of individual components and formal compounds—elemental, biological, organic and inorganic—inclusive of foodstuffs, air, water, soil, oil and gas samples. These devices may be relatively inexpensive, ruggedly designed, lightweight and capable of being employed—depending upon the specific application—by individuals with limited training, in remote and extreme environments and settings: including combat zones, disaster areas, rural communities, tropical/arctic/desert and other inhospitable climates and challenging terrains. The device may be comprised of materials that are reclaimed, are re-usable and are recyclable. | 01-30-2014 |
| 20140038276 | REACTION VESSEL - We provide a miniature, disposable reactor vessel for bioprocessing. Embodiments include a sealed vessel surrounding a filter through which spent media may be preferentially removed relative to culture cells. Preferred embodiments include an impeller shaft that is contained within the vessel and passes through the filter assembly. The impeller shaft may be engaged magnetically with a drive shaft. Combinations of these reactor vessels and methods of their use are also described. | 02-06-2014 |
| 20140038277 | INTEGRATED MICROBIAL COLLECTOR - A system for real-time sizing of fluid-borne particles is disclosed. The system further determines, in real time, whether the detected particles are biological or non-biological. As the fluid is being tested, it is exposed to a microbe collection filter which is cultured to determine the type of microbes present in the fluid being tested. | 02-06-2014 |
| 20140045251 | SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES - Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided. | 02-13-2014 |
| 20140045252 | CELL CULTIVATION CONTAINER AND CELL CULTURING APPARATUS - Provided is a cell cultivation container equipped with electrodes, which enables automatic culturing, observation of automatically cultured cells, and measurement of electrical resistances. A circular electrode ( | 02-13-2014 |
| 20140051156 | IMAGING APPARATUS - An imaging apparatus, comprising a holder that holds a specimen container carrying a biological specimen, an imager that images the specimen in the specimen container, a sterilizer that supplies a drug or electromagnetic waves having a sterilization effect to the holder, and a controller that performs a sterilization process of supplying the drug or the electromagnetic waves to the holder by controlling the sterilizer at least either before or after imaging the specimen by the imager. | 02-20-2014 |
| 20140051157 | APPARATUS AND METHOD FOR INCREASING COLLECTION EFFICIENCY IN CAPILLARY BASED FLOWCYTOMETRY - In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths. | 02-20-2014 |
| 20140051158 | SLICED SPECIMEN PREPARING APPARATUS - A sliced specimen preparing apparatus prepares a sliced specimen by slicing a surface of a specimen block in which a specimen is embedded in an embedding-substance. The apparatus includes: a cutter configured to slice the surface of the specimen block; a surface exposure determination unit configured to determine whether or not the area of a specimen portion on the surface of the specimen block is sufficient for the preparation of the sliced specimen; a specimen block transporting unit configured to transport the specimen block between the surface exposure determination unit and the cutter. The surface exposure determination unit includes a humidifying unit configured to humidify the surface of the specimen block; an irradiating unit configured to irradiate the surface of the specimen block with light; an imaging unit configured to receive reflected light from the humidified surface of the specimen block which is irradiated from the irradiating unit to acquire image data; an image data processing unit configured to discriminate the specimen portion on the surface of the specimen block from the embedding-substance portion based on the image data acquired by the imaging unit; and a controller configured to control the imaging unit, the irradiating unit, and the image data processing unit, and to determine whether or not the area of the specimen portion on the surface of the specimen block, the specimen portion being acquired by the image data processing unit, is sufficient for the preparation of the sliced specimen. | 02-20-2014 |
| 20140057342 | CULTURE APPARATUS, CULTURE APPARATUS SYSTEM, CULTURE OPERATION MANAGEMENT METHOD, AND NON-TRANSITORY STORAGE MEDIUM STORING PROGRAM - A culture apparatus includes a culture unit which cultures cells under a predetermined culture environment, and an imaging unit which captures an inspection image showing a state of a culture container which holds the cells or a state of the cells, further includes a carrying unit and a determining unit. The carrying unit delivers the culture container between at least one peripheral device to be used in a culture operation of the cells and the culture apparatus. The determining unit detects completion of the culture operation of the peripheral device, controls the imaging unit to capture the inspection image, and analyzes the inspection image to determine whether or not the culture operation by the peripheral device is appropriate. | 02-27-2014 |
| 20140065704 | CELL COLLECTION SYSTEM - The present invention provides a simple and highly reliable cell collection system with high throughput and improved in cell collection efficiency. In the present invention, one or more pores are formed in a cell collection plate. One surface of the plate can be directly introduced in e.g., a petri dish, so as to be in contact with a solution containing cells. In this case, means for obtaining an optical image of collected cells from its rear surface is provided to improve reliability and convenience during a cell collection process. Alternatively, the vicinities of the pores in the cell collection plate are only hydrophilized and the other region is made water repellent to improve the efficiency of cell collection. | 03-06-2014 |
| 20140080206 | MICROFLUIDIC SYSTEM FOR CONTROLLING A CONCENTRATION PROFILE OF MOLECULES CAPABLE OF STIMULATING A TARGET - The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: -a microfluidic device ( | 03-20-2014 |
| 20140087453 | MICROPARTICLE ANALYSIS APPARATUS AND MICROPARTICLE ANALYSIS METHOD - There is provided a microparticle analysis apparatus including a light detection unit configured to detect forward-scattered light generated from a microparticle that is an analysis target. The light detection unit includes a circuit having a high-pass filter that removes low frequency noise included in light entering the light detection unit and switches to the high-pass filter according to a predetermined frequency of the forward-scattered light. | 03-27-2014 |
| 20140093948 | Light source module and analytical instrument for analyzing a sample - A light source module for use in an analytical instrument for analyzing at least one sample is disclosed. The light source module includes at least one light-emitting diode and at least one light guiding rod adapted to guide and shape light emitted by the light-emitting diode. The light source module further includes at least one memory device. The memory device has stored therein at least one driving parameter set, for driving the light-emitting diode in such a way that desired emission properties of light provided by the light source module are generated. | 04-03-2014 |
| 20140093949 | ABSORBANCE SPECTRUM SCANNING FLOW CYTOMETRY - The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream. A particle that passes through the detection region traverses the full dispersed spectrum of excitation light, and the fluorescence emissions from the particle are continuously measured as it passes through the detection region. The measured fluorescence emissions at each wavelength of excitation light, which changes through full spectrum of the excitation light as the particle passes through the detection region, provides the excitation spectrum of the particle. | 04-03-2014 |
| 20140113358 | Systems and Methods for Focusing Particles - Provided is a method of focusing particles. The method includes: providing a suspension of the particles in a suspending medium; and flowing the suspension along a channel, such that the flowing suspension occupies a certain volume that has at least one cross-sectional dimension smaller than 100 μm. The suspending medium has such viscoelastic properties, that flowing the suspension in the channel directs at least some of the particles towards a focus region, enclosed in said certain volume. | 04-24-2014 |
| 20140113359 | HIGH SENSITIVITY SENSOR DEVICE AND MANUFACTURING THEREOF - A sensing device able to do concurrent real time detection of different kinds of chemical, biomolecule agents, or biological cells and their respective concentrations using optical principles. The sensing system can be produced at a low cost (below $1.00) and in a small size (˜1 cm | 04-24-2014 |
| 20140127794 | BACTERIA MEASURING APPARATUSES - An apparatus for measuring bacteria includes a sampling device for processing fluorescently stained bacteria, a detector for detecting size information from the bacteria in the sample, and a detector for detecting fluorescence information expressing intensity of fluorescent light emitted by the bacteria. The apparatus further includes a processor and memory that includes programs for creating a scattergram representing a distribution of the bacteria based on the size information and the fluorescence information detected, analyzing the distribution of the bacteria in the scattergram, and determining whether the bacteria in the sample is | 05-08-2014 |
| 20140134711 | MICROSTRUCTURED MEASURING CHIP FOR OPTICALLY MEASURING PROPERTIES OF ARTIFICIAL OR BIOLOGICAL MEMBRANES, AND METHOD FOR ITS PRODUCTION THEREOF - A microstructured measurement chip ( | 05-15-2014 |
| 20140134712 | OPTICAL BIOSENSOR AND MANUFACTURING METHOD THEREOF - An optical biosensor, and a method of manufacturing the same, includes a first layer, a second layer stacked on the first layer, a first grating coupler within the first layer and the second layer, and a second grating coupler within the first layer. The first grating coupler is configured to couple a light pattern provided to a front side of the optical biosensor. The second grating coupler is configured to output the light pattern coupled by the first grating coupler to a photoelectric conversion element on a rear side of the optical biosensor. | 05-15-2014 |
| 20140134713 | SPECTRAL IMAGING OF BIOLOGICAL SAMPLES - The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components. | 05-15-2014 |
| 20140134714 | SPR SENSOR DEVICE WITH NANOSTRUCTURE - A sensor device comprises a dielectric substrate ( | 05-15-2014 |
| 20140154793 | CELL ANALYZER - A cell analyzer includes a flow cell through which a sample containing a cell flows; an imaging unit that captures the cell contained in the sample flowing through the flow cell; a cell image storage unit that stores a cell image captured by the imaging unit; a light source that irradiates the sample flowing through the flow cell with light; a light receiving unit that receives light from the cell irradiated with the light from the light source and outputs a signal corresponding to a light receiving amount; a waveform data storage unit that stores data indicating change in the light receiving amount obtained based on the output signal; a display unit; and a control unit that controls the display unit to display the cell image and a graph representing a waveform of data for the cell in the cell image and/or a marker corresponding to the data. | 06-05-2014 |
| 20140162349 | QUANTITATIVE PHASE MEASUREMENT APPARATUS - Provided is a small-sized quantitative phase measurement apparatus. The quantitative phase measurement apparatus | 06-12-2014 |
| 20140170739 | INLINE SAMPLE FILTER FOR A FLOW CYTOMETER - An inline sample filter for a flow cytometer. | 06-19-2014 |
| 20140170740 | Optics Cup With Curved Bottom - The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch. | 06-19-2014 |
| 20140170741 | HEPATIC FIBROSIS DETECTION APPARATUS AND SYSTEM - A hepatic fibrosis detection apparatus and system include an input device, for receiving age and serum biochemical variables, the serum biochemical variables at least including blood platelet, hyaluronic acid, serum direct bilirubin, pro-thrombin time, serum glutamic pyruvic transaminase and serum glutamic oxaloacetic transaminase; a classifier, for performing hepatic fibrosis staging according to the age and serum biochemical variables received by the input device and transient elastography imaging data; and an output device, for outputting a result of the hepatic fibrosis staging of the classifier. The system provides various benefits such as non-invasiveness, high practicability, simple method, low cost and high safety. | 06-19-2014 |
| 20140186937 | AUTOMATED TISSUE ENGINEERING SYSTEM - The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings. | 07-03-2014 |
| 20140186938 | SERIAL-LINE-SCAN-ENCODED MULTI-COLOR FLUORESCENCE MICROSCOPY AND IMAGING FLOW CYTOMETRY - A system for performing high-speed, high-resolution imaging cytometry includes a scanning region that is illuminated by light including at least first and second wavelength bands. The system also includes a cell transport mechanism that transports a cell through the scanning region such that the cell is illuminated. The system further includes a set of at least one linear light sensor, and an optical system that selectively directs light emitted from the cell to two portions of the linear light sensor set such that emitted light in a third wavelength band is primarily directed to a first portion of the linear light sensor set, and emitted light in a fourth wavelength band is primarily directed to a second portion of the linear light sensor set. The system repeatedly takes readings of light falling on the linear light sensor set while the cell is transported through the scanning region. | 07-03-2014 |
| 20140186939 | PORTABLE WATER QUALITY INSTRUMENT - A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge. | 07-03-2014 |
| 20140193895 | AUTOMATED TISSUE ENGINEERING SYSTEM - The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings. | 07-10-2014 |
| 20140199758 | BILIRUBIN HEMATOLFLUOROMETER AND REAGENT KIT - A reagent kit for detecting bilirubin in a fluid sample. The reagent kit includes a body defining at least one fluid receiving well and an optical window positioned over each at least one fluid receiving well. Each window is formed of a material having a fluorescence intensity that is of a lower magnitude than the fluorescence to be detected from the bilirubin. A hematofluorometer configured to utilize the reagent kit is also disclosed. | 07-17-2014 |
| 20140212960 | LEUKOCYTE MEASUREMENT DEVICE AND REAGENT KIT - A leukocyte measurement device is provided with a spread inspection window at a position separated from an opening part along a spreading direction of a blood-derived sample in a carrier, for making the carrier visible from outside. When the blood-derived sample is dropped from the opening part, leukocytes contained in the blood-derived sample are captured by the carrier in the vicinity of a dropping position, while erythrocytes and/or hemoglobin and the like spread through the carrier from the dropping position into a predetermined direction. Therefore, in the leukocyte measurement device, seeing through the spread inspection window the color of the erythrocytes and/or hemoglobin spread from the dropping position can determine whether it has already been used or not, whereby a simple structure can prevent measurers from erroneously reusing it. | 07-31-2014 |
| 20140220671 | SYSTEM AND METHOD FOR DIAGNOSING LYMPHOMA IN CATS - The invention provides a method and a system for diagnosing lymphoma in cats. The system allows a care giver to measure the enzymatic activity of thymidine kinase in a blood sample. The invention teaches that when the enzymatic activity of thymidine kinase in the blood stream of a cat is above 15.5 Units per liter, the cat has a high probability of having lymphoma. The invention allows for initial diagnosis, follow up after treatment for lymphoma and/or monitoring for example in breeds that prone to have lymphoma. | 08-07-2014 |
| 20140234951 | Mixing Bag with Integral Sparger and Sensor Receiver - A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed. | 08-21-2014 |
| 20140234952 | DIAGNOSTIC APPARATUS - There is described a diagnostic apparatus ( | 08-21-2014 |
| 20140256033 | DEVICES FOR DETERMINING CELL FORCE PROPERTIES AND METHODS OF MANUFACTURING THE DEVICES - A device may be configured to allow individual measuring of at least one property of at least one cell, such as measuring a contraction force of a platelet. The device may include a plurality of wells. Each well may include a hydrogel layer, the hydrogel layer including a hydrogel having a top surface that includes a pattern of cell interaction regions. The wells may differ in stiffness properties of the hydrogel and/or biochemical conditions. Each cell interaction region may include a group of at least two cell interaction sites. The spacing between each cell interaction region may be greater than a spacing between the at least two cell interaction sites of each cell interaction region. In this way, cell-cell interactions may be reduced and thereby increasing number of individual cells capable of being measured. | 09-11-2014 |
| 20140273193 | Electrokinetic Microfluidic Flow Cytometer Apparatuses with Differential Resistive Particle Counting and Optical Sorting - The present invention provides electrokinetic microfluidic cytometers useful for detecting and/or sorting fluid-borne particles. In some embodiments, the electrokinetic microfluidic flow cytometer apparatus comprises a substrate having a microchannel formed therein, a particle-sensing gate that reduces the cross-sectional area of a portion of the microchannel, a pair of signal- and noise-detection electrodes, and a particle-detection circuit that is electrically connected to the signal- and noise-detection electrodes and is configured to generate a particle-detection signal responsive to differences in resistivity across the particle-sensing gate. | 09-18-2014 |
| 20140273194 | SYSTEM FOR IMAGING CAPTURED CELLS - A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module. | 09-18-2014 |
| 20140273195 | FINE PARTICLE MEASURING APPARATUS - A fine particle measuring apparatus is provided. The fine particle measuring apparatus includes a detection unit configured to detect light emitted from a fine particle and a processing unit having a memory device storing instructions which when executed by the processing unit, cause the processing unit to calculate a corrected intensity value of the detected light and generate spectrum data based on the corrected intensity value. | 09-18-2014 |
| 20140295535 | MEASUREMENT APPARATUS - A measurement apparatus includes: a holding unit that holds at least a specimen to be observed; an illumination unit that emits illumination light to be irradiated to the specimen; a detection unit that is arrangeably provided in the holding unit and detects an intensity of the illumination light on a light irradiation surface of the specimen; a field stop that is formed with an aperture and stops down a field on the light irradiation surface by an image of the aperture that is provided on an optical path of the illumination unit, the aperture through which the illumination light passes and through which an image of the illumination light is projected on the light illumination surface; and a computation unit that computes, based on an area of the aperture and the detected intensity, an intensity of the illumination light per unit area of the light irradiation surface. | 10-02-2014 |
| 20140295536 | PARTICLE MEASURING APPARATUS - A particle measuring apparatus comprising a flow cell configured to flow a specimen, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, an irradiation optical system configured to irradiate the flow cell with light emitted from the first light source and the second light source, a first light receiving portion configured to receive scattered light obtained by irradiating a measurement particle passing through the flow cell with light from the first light source, and a second light receiving portion configured to receive scattered light obtained by irradiating a measurement particle passing through the flow cell with light from the second light source. | 10-02-2014 |
| 20140295537 | SANITIZING FLOOR MAT - The present invention is comprised of an antibacterial door mat system for cleaning, disinfecting and detection of bacteria and other organisms on footwear to control spread of biological infections and contamination. The present invention is further comprised of an antibacterial door mat that cleans footwear, detects the presence of bacteria and a bio detection clearance door entry system that controls the entry into sterile areas. | 10-02-2014 |
| 20140295538 | DEVICE AND SYSTEM FOR MECHANICAL MEASUREMENT OF BIOMATERIAL - A test device applies a defined mechanical load to a soft biomaterial such as a cell culture and a microscope forms a volume image data set showing the strain field or displacement field occurring in the medium. The data set is processed to determine fundamental mechanical properties of the cell, its interaction with the surrounding medium, or its responses loading or deformation of its surrounding medium. The device may also be used to calibrate or determine fundamental mechanical properties of the medium. The device includes a linear actuator that bears against the specimen, and adapted for a volume imaging device such as a scanning laser confocal microscope that forms a volume image data set of the specimen. The specimen may be supported in a Petri dish and is preferably imaged from below by an inverted microscope. Preferably the actuator device attaches to or forms the specimen stage of microscope. Digital correlation of volumes in the data set allow computation of modulus, stress distribution and other mechanical characteristics of cell-matrix interactions, as well as mechanical properties of the cell and the matrix in response to changing loads, evolving chemical or ionic environment and growth phases. The test device may be operated to measure local mechanical parameters, to evaluate or design tissue-engineered implants, and to explore the mechanical properties of tissues, cells and cellular processes a micrometer scale with high accuracy. | 10-02-2014 |
| 20140302596 | MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR IDENTIFICATION - An apparatus and method to identify at least one component from a plurality of components in a fluid mixture, includes a first input channel containing the fluid mixture of components; at least one buffer input channel, into which at least one additional flow of buffer solution is introduced; a plurality of regions disposed at the other end of the apparatus, which are adapted to receive outputs of at least one selected component of the plurality of components, the selected component which is selectively removed from the first flow to one of the regions; a waste channel through which unselected components are removed from the first flow; a plurality of pumps connected to at least one reservoir, to control flow rates of the first flow and the additional flow(s); and a computer which controls a selection of one of the plurality of components from the fluid mixture. | 10-09-2014 |
| 20140315286 | Electro Medical Tool Optimization System - Methods and apparatus are disclosed herein to improve on and expand the range of electrical and electromagnetic frequencies used in therapeutic electro medical devices. The present invention uses electrical and electromagnetic frequency generators and detectors integrated with a live cell imaging system that provides feedback to the frequency generators using data derived from said imaging system. | 10-23-2014 |
| 20140315287 | SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES - A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet. The fluidic pathway includes a delivery region configured to receive the plurality of particles from the inlet and focus the plurality of particles from a random distribution to a focused state, a deformation region defining an intersection located downstream of the delivery region and coupled to the outlet, and wherein the deformation region is configured to receive the plurality of particles from the delivery region and to transmit each particle in the plurality of particles into the intersection from a single direction, a first branch fluidly coupled to the deformation region and configured to transmit a first flow into the intersection, and a second branch fluidly coupled to the deformation region and configured to transmit a second flow, substantially opposing the first flow, into the intersection, wherein the first flow and the second flow are configured to induce extension of one or more particles in the plurality of particles. | 10-23-2014 |
| 20140315288 | PARTICLE ANALYSIS APPARATUS AND PRODUCTION METHOD THEREOF - An apparatus including a flow cell part having a flow channel where a sample solution containing the particles to be analyzed flows; a light irradiation device for irradiating an irradiation light as a beam light to a light irradiation point in the flow channel; and a light receiving device for detecting the light resulting from the irradiation of the beam light to the light irradiation point. The light irradiation device has a light source device and a beam-light-forming-film composed of an opaque film and a light transmitting hole formed in the film. Using the light transmitting hole, the cross sectional shape of the irradiation light is changed to that of the beam light, whereby optical apparatuses such as lens and the like on the irradiation side are omitted. | 10-23-2014 |
| 20140315289 | DISPOSABLE CARTRIDGE FOR ERYTHROCYTE MECHANICAL FRAGILITY TEST - A disposable cartridge for use in red blood cell mechanical fragility profiling, comprising a stressing section with a lysing chamber in which the sample can receive multiple increments of mechanical stress to cause lysis, and a detection section with a transparent region that at least sometimes can have a thickness suitable to take optical readings that can directly or indirectly reflect a fraction/proportion of cells lysed after each increment of the stress, whereby said region can capture at least a representative portion of the sample that received each increment of stress. In some embodiments, the stressing section and the detection section are the same, and/or the transparent region is flexible or otherwise compressible, and/or the stress is ultrasonic. In some embodiments, the sections are separate, and/or the region is rigid or has a fixed thickness, and/or the stress may comprise cell-to-wall interaction and associated fluidic or viscous shear stress induced via concentric/coaxial objects. | 10-23-2014 |
| 20140315290 | LOW-COST PHOTOBIOREACTOR - The present invention provides a photobioreactor comprising at least one translucent flexible sheet shapable by a support assembly forming thereby an elongated channel adapted for biomass production therewithin. Kits for making a photobioreactor and a floatable photobioreactor are also provided. | 10-23-2014 |
| 20140322802 | APPARATUS FOR MEASURING BLOOD CELLS AND IMMUNITY FROM WHOLE BLOOD - In conventional apparatuses for measuring blood cells and immunity from whole blood, the CRP cell is used for the final cleaning of a nozzle, and CRP measurement—cleaning of the CRP cell—final cleaning of nozzle are performed in this order in the CRP cell. In contrast, in the present invention, an exclusive cleaning chamber A for immunity measurement is further provided for the cleaning nozzle after completion of dispensing the specimen and the reagent(s) for CRP measurement to the CRP cell. Thus, a configuration is adapted wherein the outer surface and inner surface of the nozzle are cleaned in the cleaning chamber A for immunity measurement while the immunity measurement is performed in CRP cell. Since the final cleaning of the nozzle is performed in parallel with the CRP measurement, the time conventionally necessary for the final cleaning of the nozzle can be shortened. | 10-30-2014 |
| 20140349383 | FLUORESCENT SENSOR AND SENSOR SYSTEM - A fluorescent sensor includes a detecting substrate, an indicator, a filter layer, a light blocking layer, and an LED chip. In the detecting substrate, a PD element for converting fluorescence into electric signals is positioned on wall surfaces of a through-hole which penetrates a first main surface and a second main surface. The indicator is arranged inside the through-hole and generates fluorescence of intensity corresponding to analyte density when the indicator receives excitation light. The filter layer covers the PD element, transmits fluorescence and blocks excitation light. The light blocking layer, through which an analyte can pass, covers an opening of the first main surface of the through-hole. The LED chip covers a region just below an opening of the second main surface of the through-hole, and generates excitation light. | 11-27-2014 |
| 20140356937 | Patterned Capillary Device and Process for Fabricating Thereof - A patterned capillary device comprising a pattern on an inner surface is described herein. More specifically, the patterned capillary device comprises a wall having an outer surface and an inner surface, the wall defining a fluidic channel. A substantially opaque film covers the inner surface of the wall, the opaque film comprising a plurality of substantially transparent segments defining a pattern. A process for fabricating a pattern formed of opaque and transparent portions on an inner surface of a capillary device is also described herein. | 12-04-2014 |
| 20140356938 | Method for Performing a Blood Count and Determining the Morphology of a Blood Smear - A method for counting blood cells in a sample of whole blood. The method comprises the steps of:
| 12-04-2014 |
| 20140363883 | Device for cell culture and direct imaging - A cell culture device for the study of barrier function and differentiation are provided by this invention. | 12-11-2014 |
| 20140370586 | MICROCHIP AND MICROCHIP-TYPE FINE-PARTICLE MEASURING DEVICE - A microchip is provided. The microchip includes an incident surface configured to receive light transmitted from a light source, the light being received from an incident direction and a back surface that is opposite the incident surface, the back surface including a portion that is configured to reflect light transmitted from the light source away from the incident direction. | 12-18-2014 |
| 20140377853 | AUTOMATIC ANALYZER - To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error. | 12-25-2014 |
| 20150010995 | MICROCHIP-BASED APPARATUS FOR EXAMINING PLATELET COMPOSITE FUNCTIONS - There is provided a microchip-based platelet multi-function test apparatus. The apparatus includes a sample container configured to accommodate a blood sample therein, a stirrer that is installed inside the sample container and induces a shear flow in the blood sample, a parallel channel configured to divide and flow the blood stirred by the stirrer into a plurality of paths, a vacuum device that is connected to an end of each parallel channel, maintains constant pressure, allows the stirred blood to flow along the parallel channel, a light source that is installed in a rear side of the parallel channel and radiates light to the parallel channel, and an image sensor that receives light transmitted through the blood in the parallel channel, converts the light into an electrical signal, and measures a flowing distance of a blood flow. | 01-08-2015 |
| 20150024476 | CELL SORTING SYSTEM AND METHODS - Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., | 01-22-2015 |
| 20150024477 | BIOSENSOR CHIP, AND BIOSENSOR DEVICE EQUIPPED WITH SAME - This biosensor chip is placed in a biosensor device and is rotated while a specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which a biochemical analysis specimen is poured. The holding chamber holds the poured specimen inside the main body. The dispensing chamber is connected to the holding chamber via a first channel and dispenses the specimen. The plurality of quantification chambers are connected to the dispensing chamber, hold a specific amount of dispensed specimen, and are disposed at positions located away from the rotational center of the rotary motion according to the distance from the first channel. The plurality of measurement chambers are connected to the quantification chambers via a second channel and react the specimen with a biochemical analysis reagent. | 01-22-2015 |
| 20150031120 | MEMS PARTICLE SORTING ACTUATOR AND METHOD OF MANUFACTURE - A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid. | 01-29-2015 |
| 20150031121 | SAMPLE HOLDING CARRIER AND FLUORESCENCE DETECTION DEVICE USING SAME - Disclosed is a sample holding carrier allowing samples to be measured accurately, and a fluorescence detection device for use with the sample holding carrier. A biosensor substrate includes a base substrate, a plurality of wells formed on a first surface side of the base substrate; and grooves formed on the first surface side of the base substrate separately from the wells and generating fluorescence under exposure to excitation light. The fluorescence detection device applies excitation light to the grooves, thereby figuring out the level of the fluorescence to be detected from the biosensor substrate. As a result, the fluorescence detection device can amplify the detection signals of the fluorescence generated when the excitation light is applied to the wells to an appropriate level, thereby accurately detecting the fluorescence generated in the samples. | 01-29-2015 |
| 20150037877 | Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths - A fast fluorescence lifetime microscopic system images FRET between multiple labels in live cells and deep tissue, using a quantitative analysis method to reconstruct the molecular machinery behind the multiplexed FRET phenomenon. The system measures fluorescence lifetime, intensity and anisotropy as images of excitation-emission matrices (EEM) in real time and high speed within a single image scan, performs high-resolution deep-penetrating 3D FRET imaging in live samples, and fully analyzes all possible photon pathways of multiplexed FRET. The system provides a way for systematic and dynamic imaging of biochemical networks in cells, tissue and live animals, which will help to understand mechanisms of genetic disorders, cancers, and more. | 02-05-2015 |
| 20150044763 | FRET MEASUREMENT DEVICE AND FRET MEASUREMENT METHOD - FRET measurement uses a FRET probe that includes a probe element X labeled with a donor fluorescent substance and a probe element Y labeled with an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. A test sample as a measuring object in FRET measurement contains a test object about which it is unknown whether or not it has an approaching/binding property of allowing the probe element X and the probe element Y to approach to each other or bind together or a separating property of separating from each other the probe element X and the probe element Y that are in a state where they adjoin each other or bind together. A plurality of sets of a fluorescence lifetime τ | 02-12-2015 |
| 20150044764 | BIOCHEMICAL ASSAY CARTRIDGE - The present invention relates to a biochemical assay cartridge. More particularly, the present invention provides a biochemical assay cartridge including an insertion-type solution cartridge and a reaction cartridge receiving the insertion-type solution cartridge, in which the solution cartridge is inserted into the reaction cartridge to catch a protruding protection film inducement unit by a latch in the reaction cartridge and thus break the protection film inducement unit and a protection film for sealing a reaction solution storage unit attached to the solution cartridge is automatically detached to discharge the reaction solution from the solution cartridge to the reaction cartridge. The biochemical assay cartridge according to the present invention is automatically injected into the reaction cartridge while a sample to be subjected to assay is inserted, through the insertion-type solution cartridge, into the reaction cartridge, and thus user convenience and operability of the assay cartridge are improved. | 02-12-2015 |
| 20150050723 | Optoelectronic Detection System - The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples. | 02-19-2015 |
| 20150056690 | SPECTRAL IMAGING OF BIOLOGICAL SAMPLES - The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components. | 02-26-2015 |
| 20150064777 | APPARATUS FOR DETECTING MICROORGANISMS - Provided is an apparatus for detecting microorganisms, including: a sample accommodation container having an accommodation space in which a measurement sample in which a number of living microorganisms is to be counted is accommodated; an electrode portion installed at the sample accommodation container so as to apply electrical stimulation to the microorganisms of the sample accommodated in the accommodation space; a current applying control portion that is capable of controlling a current applied by the electrode portion; and an image processor that captures an image of the sample accommodated in the sample accommodation container and counts the number of living microorganisms. Accordingly, the number of living microorganisms can be easily identified by electrically stimulating the living microorganisms, and by comparing an image of the living microorganisms generated before electrical stimulation is applied to the living microorganisms with an image of the living microorganisms generated after electrical stimulation is applied to the living microorganisms, the number of living microorganisms can be easily measured. | 03-05-2015 |
| 20150064778 | RAMAN SPECTROSCOPIC APPARATUS, RAMAN SPECTROSCOPIC METHOD, AND ELECTRONIC APPARATUS - A Raman spectroscopic apparatus analyzes a substance under analysis and includes a light source that emits light of a first wavelength, an optical device that adsorbs the substance under analysis and is irradiated with the light of the first wavelength, and an optical detector that receives light radiated from the optical device. The optical device includes a first structural member that generates charge transfer resonance in response to the light of the first wavelength and a second structural member that is less than or equal to 5 nm from the first structural member and generates surface plasmon resonance in response to the light of the first wavelength. The first structural member is made of a metal or a semiconductor, and the second structural member is made of a metal different from the material of the first structural member. | 03-05-2015 |
| 20150072406 | PORTABLE DIAGNOSTIC TEST APPARATUS - Provided is a portable diagnostic test apparatus including: an accommodation portion including an outer side, an inner side, and an accommodation space provided on the inner side; a hinge; and a main body coupled to the accommodation portion by the hinge, where the portable diagnostic test apparatus is configured to be opened and closed by rotating one of the accommodation portion and the main body about the hinge, and where the main body is configured to obtain a result of a measurement based on data collected from drawn blood. The main body and/or the accommodation portion includes at least one strip keeping portion configured to store at least one strip. The at least one strip keeping portion may include: a housing; a discharge portion; and a first movement portion configured to move one of the strips to the discharge portion. | 03-12-2015 |
| 20150087050 | FUNCTIONALIZED POROUS SILICON NANOPARTICLES AND USE THEREOF IN PHOTODYNAMIC THERAPY - Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle. | 03-26-2015 |
| 20150087051 | SYSTEM AND METHOD FOR GENERATING INVASIVELY HYPERPOLARIZED IMAGES - The present invention includes a system and method for generating images of at least one Unhyperpolarized portion of a specimen by indirectly hyperpolarizing the at least one portion by irradiating the unhyperpolarized portion by radiation emitted from the de-excitation of excited nuclei of a hyperpolarized substance. The hyperpolarized substance is located in proximity to the specimen. Typically, the images are generated by an MRI/NMR device. | 03-26-2015 |
| 20150093817 | Particle manipulation system with out-of plane channel - A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stem cell, zygote, a cancer cell, a T-cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel. | 04-02-2015 |
| 20150099292 | SPECTROMETER - A spectroscopic system is provided. In one embodiment, the spectroscopic system comprises a light source adapted to provide a beam of illumination; an optical system adapted to provide the beam of illumination to a sample and receive a spectroscopy signal from the sample and direct the spectroscopy signal to at least one single channel detector, wherein the optical system comprises an adjustable dispersing element for directing one or more spectral features of the spectroscopy signal to the at least one single channel detector; a calibration detector adapted to determine a set point of the adjustable dispersing element; and a source synchronization component adapted to synchronize an operation of the light source and the at least one single channel detector. A method of calibrating a dispersing element of a spectrometer is also provided. | 04-09-2015 |
| 20150111291 | CELL DIVISION TRACKING APPARATUS AND METHOD OF THE SAME, AND NON-TRANSITORY COMPUTER READABLE STORAGE MEDIUM TO STORE A CELL DIVISION TRACKING PROGRAM - A cell division tracking apparatus includes a control unit, a search range setting unit, a daughter cell judgment unit. The control unit tracks division processes of the cells based on a cell image group composed of the cell images. The search range setting unit sets a search range to search for daughter cell regions corresponding to daughter cells resulting from a division of a mother cell based on the mother cell region detected by the mother cell detection unit. The daughter cell judgment unit judges whether the cell regions are the daughter cell regions based on a region in which regions of the cell overlap the search range regarding the cell images collected at and after a detection of the mother cell region. | 04-23-2015 |
| 20150125943 | LIGHT FIELD IMAGE SENSOR, METHOD AND APPLICATIONS - An angle-sensitive pixel (ASP) device that uses the Talbot effect to detect the local intensity and incident angle of light includes a phase grating disposed above a photodiode assembly or a phase grating disposed above an analyzer grating that is disposed above a photodiode assembly. When illuminated by a plane wave, the upper grating generates a self-image at a selected Talbot depth. Several such structures, tuned to different incident angles, are sufficient to extract local incident angle and intensity. Arrays of such structures are sufficient to localize light sources in three dimensions without any additional optics. | 05-07-2015 |
| 20150125944 | SUBMERSIBLE FLOW IMAGER - Submersible technology capable of sampling and evaluating suspended particulate materials, including living and dead organisms, is disclosed herein. In addition to fluorescent imaging and analysis, the invention provides automated cell staining, cell sorting, particulate concentration, and organism recovery and preservation. These new technologies may be incorporated into a traditional “fully vertical flow path” cytometer configuration most suitable for anchored or suspended stationary embodiments, or in a novel modularized “low relief” configuration, suitable for integration into or on a submersible aquatic vehicle or in other low clearance installations, where it is important to limit the vertical height of the device. | 05-07-2015 |
| 20150125945 | CENTRIFUGE CONFIGURATIONS - Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample. | 05-07-2015 |
| 20150140648 | DISPOSABLE CHIP-TYPE FLOW CELL AND FLOW CYTOMETER USING SAME - The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside. | 05-21-2015 |
| 20150147804 | BIOCHEMICAL ANALYSIS CARTRIDGE HAVING IMPROVED OPERABILITY - The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which,as the sample cartridge is inserted into the reaction cartridge,a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability. | 05-28-2015 |
| 20150292995 | METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES - Kits and systems for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the kit including concentration agent; and a system for isolating microorganisms from a sample. | 10-15-2015 |
| 20150293012 | RECEPTACLE AND SYSTEM FOR OPTICALLY ANALYZING A SAMPLE WITHOUT OPTICAL LENSES - The invention relates to a receptacle ( | 10-15-2015 |
| 20150293024 | Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength - An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers. | 10-15-2015 |
| 20150316564 | Blood Analyzing Device for Malaria Analysis - A blood analyzing device ( | 11-05-2015 |
| 20150323460 | Bilirubin Hematofluorometer and Reagent Kit - A hematofluorometer an excitation source configured to generate an excitation beam, a fluorescence detector configured to a fluorescence beam, and a housing configured to receive a reagent kit for detecting bilirubin in a fluid sample. The reagent kit includes a body defining at least one fluid receiving well and an optical window positioned over each at least one fluid receiving well and a light passage window opposite each optical window. Each window is formed of a material having a fluorescence intensity that is of a lower magnitude than the fluorescence to be detected from the bilirubin. A light sensor within the housing is configured to detect light passing through the reagent kit. | 11-12-2015 |
| 20150330903 | Near-Infrared Optical Interfaces for Disposable Bioprocessing Vessels - An optical sampling apparatus for disposable flexible bioprocessing vessels includes features for optical interrogation of the vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the vessels during bioprocesses. | 11-19-2015 |
| 20150337352 | RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING SYSTEM BASED ON BACTERIAL IMMOBILIZATION USING GELLING AGENT, ANTIBIOTIC DIFFUSION AND TRACKING OF SINGLE BACTERIAL CELLS - A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results. | 11-26-2015 |
| 20150338338 | Method and Apparatus for Determining Markers of Health by Analysis of Blood - Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time. | 11-26-2015 |
| 20150360225 | MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR QUANTIFYING PARTICLES USING CENTRIFUGAL FORCE - Embodiments of the present invention are directed toward microfluidic systems, apparatus, and methods for measuring a quantity of cells in a fluid. Examples include a differential white blood cell measurement using a centrifugal microfluidic system. A method may include introducing a fluid sample containing a quantity of cells into a microfluidic channel defined in part by a substrate. The quantity of cells may be transported toward a detection region defined in part by the substrate, wherein the detection region contains a density media, and wherein the density media has a density lower than a density of the cells and higher than a density of the fluid sample. The substrate may be spun such that at least a portion of the quantity of cells are transported through the density media. Signals may be detected from label moieties affixed to the cells. | 12-17-2015 |
| 20150362716 | CELL SUCTION SUPPORT SYSTEM - A cell suction support system includes: an image acquisition unit that acquires a microscopic image of a group of cells in a cell container; an image processor that uses the microscopic image to calculate a characteristic amount of each cell, and detects a cell having a characteristic amount that satisfies a predetermined condition; a display that displays information concerning the group of cells so that the detected cell is distinguishable; and a movement controller that moves the cell container so that a designated specific cell is placed at a predetermined suction position, while moving a suction tip to the suction position. | 12-17-2015 |
| 20150367346 | CELL SORTING SYSTEM USING MICROFABRICATED COMPONENTS - A MEMS-based cell sorter is disclosed, which uses a novel combination of features to accomplish the cell sorting using a microfabricated cell sorting valve housed in a disposable cartridge. The features include an interposer that provides fluid communication between the microfluidic passages in the silicon substrate and a plurality of fluid reservoirs in the cartridge, including a sample, sort and waste reservoir The disposable cartridge may include other features that assist in the handling of small volumes of fluids, such as a siphon region in the sort reservoir and funnel-shaped regions in the sample and waste reservoirs. A mixing mechanism may be provided for stirring the contents of the sample reservoir. | 12-24-2015 |
| 20150369725 | OPTICAL SYSTEM FOR PARAMETER CHARACTERIZATION OF AN ELEMENT OF BODY FLUID OR TISSUE - Biophotonic device for the point-of-care, real-time, non-invasive determination of parameters with diagnostic relevance, in particular an optical system for parameter characterization of an element of body fluid or tissue comprising an optical device which comprises: a light source for emitting light onto the element; and a spectrometer for recording the spectrum of light from the element, said light from the element being of transmittance, reflectance or Raman scattering of the emitted light by said element; the optical system further comprising a data processing module configured to: convert the recorded spectrum by a conversion matrix into a standardized spectrum, wherein said conversion matrix has been obtained by calibrating the optical system spectrum response against a spectrum reference; pre-process the converted spectrum; correlate, for parameter quantification, the converted pre-processed spectrum with pre-obtained spectral bands for each parameter; said spectrum being contained within uv-vis-nir wavelengths. Also methods of operating said system. | 12-24-2015 |
| 20150376564 | SYSTEMS AND METHODS FOR AUTOLOGOUS BIOLOGICAL THERAPEUTICS - An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component. The concentration and flow logic and control component is configured to: determine a first volume of a target cell-poor fraction in the first vessel to mix with a target cell-rich fraction in the second vessel in order to form a target cell-rich concentrate having a concentration of target cells that is within a target concentration range; and control the second valve to transfer the first volume of the target cell-rich fraction from the first vessel to the second vessel to form the target cell-rich concentrate. The target concentration range is between 1.0 and 1.5×106 target cells/μL. | 12-31-2015 |
| 20150377866 | PREPARATION ELEMENT SET, PREPARATION, MANUFACTURING METHOD OF PREPARATION, IMAGING APPARATUS, AND IMAGING METHOD - A preparation element set including an image sensor including a sensor surface, a sensor back surface, and a board; a package including a front surface, a back surface, and terminals on the back surface, the front surface touching or facing the sensor back surface; and a transparent plate facing the sensor surface with a subject placed therebetween, wherein the board includes a board surface and a board back surface, a distance between the board surface and the sensor surface is less than a distance between the board back surface and the sensor surface, a distance between the board surface and the sensor back surface is more than a distance between the board back surface and the sensor back surface, conductive holes pierce the board from the board surface to the board back surface, and conductors on the board surface are electrically connected to terminals by using the conductive holes. | 12-31-2015 |
| 20160003729 | FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING - Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements. | 01-07-2016 |
| 20160018314 | PARTICLE ANALYSIS APPARATUS - A particle analysis apparatus for flow cytometry, which contains a flow cell having a flow channel for flowing a sample solution containing particles to be analyzed, a light source device for emitting an irradiation light, an optical system for irradiating the irradiation light on an irradiation segment in the flow channel, and a light receiving device for detecting the light obtained thereby. A light source of the light source device is LED, and an electrode formed on a light extraction surface thereof mainly contains a plurality of electric conductor lines arranged in parallel to each other. | 01-21-2016 |
| 20160024454 | DEVICES TO EXPOSE CELLS TO FLUID SHEAR FORCES AND ASSOCIATED SYSTEMS AND METHODS - The present technology relates generally to devices to expose cells to fluid shear forces and associated systems and methods. In particular, several embodiments are directed toward devices to expose cells to fluid shear forces in order to measure changes in internal cell forces. In some embodiments, a fluidic device includes a flow unit configured to induce fluid flow through the device. The device further includes a fluid channel configured to accept a biological sample dispersed on an array of flexible structures. The flow unit can be configured to induce disturbed and/or laminar flow in the fluid channel. The device can further include optical or magnetic detection means configured to measure a degree of deflection of one or more flexible structures in the array. | 01-28-2016 |
| 20160033413 | METHODS AND DEVICES FOR XEROGEL BASED SENSORS - Chemical sensors today are deployed in massive volumes across multiple industries and yet at the same time they are subject to substantial research and development effort to establish new, faster, lower cost, more accurate, more sensitive chemical sensors. Such sensors and sensor arrays are being exploited across chemistry, biology, clinical biology, environmental science in civilian and military markets. Amongst the many sensor methodologies are xerogel substrates with two moieties, a receptor for molecular recognition of the analyte and a luminophore for signaling the recognition event. In order to fulfill the requirements for low cost there is a requirement for electronic excitation/read circuits that can support architectures with optical source—N sensors—X filters—M detectors, where M≧N and X=N|M. According to embodiments of the invention electronic excitation/read circuits for phase based luminophore sensors are presented that are compatible with single CMOS chip implementation and monolithic integration of the optical excitation/detection elements. | 02-04-2016 |
| 20160061732 | BLOOD ANALYZER, DIAGNOSTIC SUPPORT METHOD, AND NON-TRANSITORY STORAGE MEDIUM - A blood analyzer comprises a light source unit configured to irradiate light on a measurement sample prepared from blood, a fluorescent light detecting unit configured to detect auto-fluorescence produced by red blood cells in the measurement sample which is irradiated by light, an information processing unit configured to obtain auto-fluorescence information related to red blood cells which produce auto-fluorescence detected by the fluorescent light detecting unit. The information processing unit is configured to make a determination regarding anemia based on the auto-fluorescence information. | 03-03-2016 |
| 20160077083 | CELL ANALYSIS APPARATUS AND METHOD - Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds. | 03-17-2016 |
| 20160084814 | SUBMERSIBLE FLOW IMAGER - Submersible technology capable of sampling and evaluating suspended particulate materials, including living and dead organisms, is disclosed herein. In addition to fluorescent imaging and analysis, the invention provides automated cell staining, cell sorting, particulate concentration, and organism recovery and preservation. These new technologies may be incorporated into a traditional “fully vertical flow path” cytometer configuration most suitable for anchored or suspended stationary embodiments, or in a novel modularized “low relief” configuration, suitable for integration into or on a submersible aquatic vehicle or in other low clearance installations, where it is important to limit the vertical height of the device. | 03-24-2016 |
| 20160108350 | LIQUID DELIVERY DEVICE AND CELL CULTURE DEVICE USING SAME - The liquid feeder includes a liquid feeding pipe having a liquid introduce port and a liquid discharge port, a housing container which holds liquid to be introduced from the liquid introduce port, a liquid feed mechanism which feeds the liquid in the liquid feeding pipe to the liquid discharge port, a gas introduce unit which introduces gas into the liquid feeding pipe, and a liquid level detection unit which detects an advancing liquid level of the liquid to be fed in the liquid feeding pipe. The gas introduce unit is connected to a branch part provided in the liquid feeding pipe on the upstream side of the liquid feed mechanism. The liquid level detection unit is provided on the downstream side of the branch part. | 04-21-2016 |
| 20160108353 | CULTURE OBSERVATION APPARATUS AND CULTURE OBSERVATION SYSTEM - An object is to lessen a troublesome checking task during cell culturing. A culture observation apparatus of the present invention includes: a light source unit that radiates illumination light onto the inside of a transparent culture vessel from a side surface of the culture vessel; an image acquisition unit that images, of the illumination light radiated from the light source unit, scattered light emitted from the inside of the culture vessel to acquire images; and a transmission unit that sends the images acquired by the image acquisition unit to the outside. The image acquisition unit includes a sensor array that has a plurality of sensors arranged in at least one line over approximately the entire length in one direction of a bottom surface of the culture vessel and a movement mechanism that relatively moves the sensor array and the culture vessel in a direction intersecting the array direction of the sensors and extending along the bottom surface. | 04-21-2016 |
| 20160109353 | ANALYZING SYSTEM AND ANALYZING APPARATUS - An analyzing system includes an imaging cytometer having a first imaging section configured to perform an imaging of particles contained in an analyte sample to generate images, the imaging cytometer being configured to analyze the images generated by the first imaging section, and a blood cell analyzing apparatus configured to analyze particles contained in the analyte sample by at least one of an electrical resistance method and an optical analyzing method. One of the imaging cytometer and the blood cell analyzing apparatus has an analyzing section configured to produce a report of an analysis of the analyte sample based on particle information acquired by the imaging cytometer and particle information acquired by the blood cell analyzing apparatus. | 04-21-2016 |
| 20160109354 | DEVICE FOR COUNTING - A counting device counts the number of counting objects in liquid in a flexible container. The counting device includes a mounting table on which the container is mounted and a pressing table arranged opposite to a container-arranged side of the mounting table. The mounting table and the pressing table move relatively in a direction of sandwiching the container, and a light-passing hole facing a surface of the container is provided in at least one of the mounting table and the pressing table. The pressing table includes one or more thickness-setting members that sandwich the container between the pressing table and the mounting table in a periphery of the light-passing hole and on the side opposite to the container in a protruding manner. | 04-21-2016 |
| 20160121280 | DROPLET COLLISION SUBSTANCE MIXING APPARATUS AND DROPLET COLLISION SUBSTANCE MIXING METHOD - To provide a substance mixing apparatus that is capable of uniformly mixing a certain amount of trace substances and also mixing minute particles. | 05-05-2016 |
| 20160123868 | OBSERVATION APPARATUS - With the object of preventing deterioration of or damage to a photodetector caused by excessive light by more reliably preventing the excessive light from entering the photodetector, a microscope of the present invention is provided with a high-sensitivity detector, such as an HPD, a GaAsP, an EM-CCD or the like, that detects observation light coming from a specimen, a box-shaped casing that has an opening that allows contained items to be placed therein and removed therefrom and that covers the high-sensitivity detector, a door that can close off the opening of the casing, a switch that restricts light detection by the high-sensitivity detector by turning on and off a drive voltage to be applied to the high-sensitivity detector, and an opening restricting mechanism that allows the opening of the casing in the closed state imposed by the door to be opened only when the light detection by the high-sensitivity detector is restricted by the switch. | 05-05-2016 |
| 20160139049 | OPTICAL SENSOR AND MEASURING APPARATUS FOR QUANTITATIVELY DETECTING AN ANALYTE IN A SAMPLE - A sensor for quantitatively detecting an analyte in a sample, wherein an optical behavior of at least one dye depending on the analyte is used for the quantitative detection is provided. The at least one dye is contained in a medium. A restrictor is provided in order to mechanically limit volume changes of the medium. Furthermore, an osmolality in the medium is set in such a way that the osmolality is higher than the highest sample osmolality for which the sensor is to be used. The cooperation of the restrictor with the specified high osmolality results in a greatly reduced osmolality cross-sensitivity of the sensor. The restrictor can be embedded into the medium as a membrane, mat, braided material, woven fabric, or mesh. Alternatively, the restrictor can also include a carrier plate having a plurality of recesses, in which the medium is arranged. A corresponding measuring apparatus is also provided. | 05-19-2016 |
| 20160153888 | WAVEGUIDE STRUCTURE | 06-02-2016 |
| 20160169809 | SELF-TRIGGERED FLOW CYTOMETER | 06-16-2016 |
| 20160178619 | TOXIN ACTIVITY ASSAYS, DEVICES, METHODS AND SYSTEMS THEREFOR | 06-23-2016 |
| 20160202040 | METHOD FOR CALIBRATING A LASER DEFLECTION APPARATUS OF A LASER MICRODISSECTION SYSTEM AND LASER MICRODISSECTION SYSTEM | 07-14-2016 |
| 20160202173 | METHOD AND APPARATUS FOR THE IDENTIFICATION AND HANDLING OF PARTICLES | 07-14-2016 |
| 20160252447 | SYSTEM AND METHOD FOR INERTIAL FOCUSING CYTOMETER WITH INTEGRATED OPTICS FOR PARTICLE CHARACTERIZATION | 09-01-2016 |
| 20180024040 | COMPACT DETECTION MODULE FOR FLOW CYTOMETERS | 01-25-2018 |
| 20180024110 | FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITIY OF LIVING TISSUE LAYERS | 01-25-2018 |
| 20190143329 | MICROFABRICATED DROPLET DISPENSING DEVICE | 05-16-2019 |
