| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435379000 | Using mechanical means (e.g., trituration, etc.) | 38 |
| 20090142835 | STEM CELL SEPARATING MATERIAL AND METHOD OF SEPARATION - The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0×10 | 06-04-2009 |
| 20090148946 | SEPARATION SYSTEM FOR CELL, AND CELL CULTURE SYSTEM USING SEPARATOR FOR CELL, AND METHOD OF SEPARATION FOR CELL - A cell is separated from a culture broth with an extremely simple configuration, and production yield of a target product is improved. There are provided separating means for separating a cell from the culture broth containing the cell, a buffer tank connected to the separating means through a first pipeline, at least one or more liquid reservoir tank connected to the buffer tank through a second pipeline, a first valve disposed on the first pipeline and controlling communication between the separating means and the buffer tank, and a second valve disposed on the second pipeline and controlling communication between the buffer tank and the liquid reservoir tank. | 06-11-2009 |
| 20090221075 | System And Process For Separating A Material - Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations. | 09-03-2009 |
| 20090305412 | MECHANICALLY REVERSIBLE GEL - The present invention relates to a process for making a gel comprising combining a silanol species comprising at least two silanol groups per molecule and a hydrophilic hydroxyl species comprising at least two hydroxyl groups per molecule. The gel is capable of being converted to a liquid by application of a mechanical shear force and the liquid is capable of being converted to the gel in the absence of said mechanical shear force. | 12-10-2009 |
| 20100062529 | APPARATUS AND METHOD FOR THE DEPOSITION OF BIOLOGICAL MATERIAL IN A TARGET SUBSTRATE - Disclosed is a deposition apparatus ( | 03-11-2010 |
| 20100087003 | DEVICE AND METHOD FOR THE MECHANICAL DECOLLATION OF CELLS FROM A CELL COMPOSITE - A device for mechanically decollating cells from a cell composite, particularly a shear rotor, a cell isolation unit including such a shear rotor and a method for decollating cells from a cell composite. The aforementioned device includes a rotor having a rotor wall, which is concentrically arranged in a receptacle. A rotor seat is connected to a motor and to which the rotor can be fixed in a detachable manner. A rotational movement of the motor can be transmitted to the rotor by means of the rotor seat. The rotor tapers longitudinally towards the bottom of the receptacle so that different circumferential speeds of the rotor can be transmitted to a liquid sample in the receptacle via the rotor wall. | 04-08-2010 |
| 20100136690 | SLICING DEVICE - The invention relates to a biological microglia comprising at least two pores having a size adopted to allow cells, cell aggregates, tissue or other biological material to pass through said pores, and one or several slicing beams separating said pores from each other, wherein biological material is split/sliced/cleaved into at least two parts when passing said microgrid, a slicing device, an apparatus comprising said slicing device as well as the use of said microgrid, slicing device and apparatus. | 06-03-2010 |
| 20100248367 | Method for isolation of inner cell mass and method of preparation of embryonic stem cell lines using inner cell mass isolated by the same - A method for isolation of an inner cell mass and a method for preparation of embryonic stem cell lines using the inner cell mass isolated by the same. A blastocyst being free from a zona pellucida removed therefrom is placed on a feeder cell, and a micro cover glass is put on the blastocyst to apply pressure caused by a weight of the micro cover glass, to the blastocyst for a desired time, so that the inner cell mass may be obtained with considerably improved yield compared to conventional methods, and therefore, an embryonic stem cell line may be efficiently established and proliferated. | 09-30-2010 |
| 20100285588 | Apparatus and Methods for Cell Isolation - A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form. | 11-11-2010 |
| 20100297766 | Method of Removing Undesired Tissue from Connective Tissue - A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof. | 11-25-2010 |
| 20100323445 | METHODS, APPARATUS AND SYSTEMS FOR PRODUCTION, COLLECTION, HANDLING, AND IMAGING OF TISSUE SECTIONS - Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). This tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples. | 12-23-2010 |
| 20100323446 | Method of collecting placental cells - Provided herein are improved methods of collecting and recovering placental cells from a mammalian placenta, comprising, e.g., perfusing a mammalian placenta in a closed system such as a sterile bag and folding the placenta at least once during perfusion. Such folding, and perfusion, can be performed mechanically. | 12-23-2010 |
| 20100330673 | METHODS OF MAKING ENHANCED, AUTOLOGOUS FAT GRAFTS - Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient. | 12-30-2010 |
| 20110003388 | METHODS OF MAKING ENHANCED, AUTOLOGOUS FAT GRAFTS - Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient. | 01-06-2011 |
| 20110014705 | METHOD AND APPARATUS FOR SEPARATING BIOLOGICAL MATERIALS - According to various embodiments, a system can be provided to separate undifferentiated cells and/or stromal cells from a whole tissue sample. The whole tissue sample can be any appropriate tissue sample obtained directly from a patient. The tissue sample can be obtained during a selected operating procedure for immediate or quick application or re-application to the patient. Accordingly, autologous cells can be obtained intraoperatively for application to a patient substantially soon after obtaining a whole tissue sample. | 01-20-2011 |
| 20110086426 | METHODS AND APPARATUS FOR COLLECTING AND SEPARATING REGENERATIVE CELLS FROM ADIPOSE TISSUE - Methods and apparatus for: collecting adipose tissue in a syringe; subjecting the collected adipose tissue to heat, vibration, and or centrifugation whilst remaining within the syringe; and filtering the adipose tissue during centrifugation such that the regenerative cells are permitted to pass into a reservoir of a collection sleeve. | 04-14-2011 |
| 20110111503 | Method for excising biological samples on a solid support - The present invention provides a method for excising a biological sample on a solid support while minimizing risk of carry over contamination. Furthermore, analytical kits and systems as well as an excising device for excising a biological sample on a solid support are provided. | 05-12-2011 |
| 20110124106 | SEPARATION DEVICE - A separation device for separating a wanted end product from a liquid sample comprises a container ( | 05-26-2011 |
| 20110189772 | BIOREACTOR WITH DUAL COMPARTMENT - The invention relates to a method for using a dual-compartment bioreactor that comprises a flexible pouch ( | 08-04-2011 |
| 20110195502 | CENTRIFUGAL ROTOR AND METHOD FOR USING THE SAME FOR DELIVERING BIOLOGICAL SAMPLE - Disclosed herein is a centrifugal rotor for delivering and analyzing biological sample. Chambers within the centrifugal rotor is used to split a biological sample, which comprises biological cellular components and biological fluids, into separate parts under centrifugal force after the biological sample being diluted, metered and distributed by the centrifugal rotor. | 08-11-2011 |
| 20110201115 | METHOD AND APPARATUS FOR PRODUCTION OF A SKIN GRAFT AND THE GRAFT PRODUCED THEREBY - A micro-organ structure comprising at least two micro-organ portions formed from a tissue, in which said at lest two micro-organs are linked one to the other by means of a junction formed from said tissue of which the micro-organs were formed therefrom. | 08-18-2011 |
| 20110256627 | Cutting device for culturing the next generation of cells - The present invention is related to a device for subculturing embryonic stem cells, which mainly contains a cutting brush having a handle and a brush stem. The brush stem has a stem and a plurality of discrete upright wires disposed on the stem. The brush stem is mounted onto a front end of the handle, and an angle between the brush stem and the handle ranges from 70 to 90 degrees. The distance between two adjacent wires is smaller than the diameter of a block of the embryonic stem cells to be cut for next generation culturing, so that the cutting brush can evenly cut the block into a plurality of smaller blocks of embryonic stem cells. | 10-20-2011 |
| 20120264213 | Device and method for delivering mechanically released cells from liposcuction aspirates - A lipoaspirate collection device to aid in the collection and processing of human tissue and fluid obtained during liposuction for use in point-of-care cell therapy. The collection device includes a collection body and a collection cap. The collection cap may have a fluid port, a lipoaspirate port, a vacuum port, and a relief valve. Within the central cavity of the collection device, a cone shaped may be positioned such that the apex of the cone is positioned underneath the lipoaspirate inlet through which the lipoaspirate fluid and tissue are introduced. | 10-18-2012 |
| 20120315702 | CELL CULTURE PROCESSING DEVICES AND METHODS - Embodiments are directed to devices and methods for processing, cultivating or otherwise manipulating cell cultures which may be disposed on a flat or substantially flat surface such as cell culture substrate material. Devices and methods are disclosed for dividing a cell culture layer into divided portions, including isolated divided portions, that may then be transferred from the cell culture to a new location. For some embodiments, the divided portions may be transferred to a new cell culture support substrate in order to continue to grow and cultivate the cell line. | 12-13-2012 |
| 20130115697 | METHODS AND APPARATUS FOR ENHANCED RECOVERY OF CELLS FROM TISSUE SAMPLES - This document describes methods and an apparatus for recovery of cells from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed. | 05-09-2013 |
| 20130295673 | SYSTEMS AND METHODS FOR PROCESSING CELLS - The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user. | 11-07-2013 |
| 20140162362 | Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus - Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies. | 06-12-2014 |
| 20140273221 | SUBSTRATES FOR GENERATION OF CONTROLLED HUMAN PLURIPOTENT STEM CELL COLONY SIZE AND SHAPE - Methods of cell culture using patterned SAM arrays are disclosed. Advantageously, the disclosed methods use SAM arrays presenting adhesion peptides to grow confluent monolayers that can invaginate to form an embryoid body. | 09-18-2014 |
| 20140377866 | MICROFLUIDIC TUMOR TISSUE DISSOCIATION DEVICE - A tissue dissociation device includes an inlet coupled to a first stage having a single channel having an upstream end and a downstream end; a plurality of serially arranged intermediate stages, wherein a first intermediate stage of the plurality is fluidically coupled to the downstream end of the first stage, and wherein each subsequent intermediate stage of the plurality has an increasing number of channels (with channels of smaller dimensions); and an outlet coupled to a last stage of the intermediate stages. | 12-25-2014 |
| 20150079679 | SYSTEMS AND METHODS FOR PROCESSING CELLS - The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user. | 03-19-2015 |
| 20150118752 | TISSUE PROCESSING APPARATUS AND METHOD FOR PROCESSING ADIPOSE TISSUE - A portable apparatus useful for collection and processing of human biological material containing adipose, such as extracted during a lipoplasty procedure to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material or fat graft material, which access may be via a lumen through a rotatable mixer shaft. Access ports may be configured for access only from above the container. The apparatus may include a tissue collector disposed in the disuse retention volume to engage and collect collagen or other stringy tissue. A method of processing adipose tissue to concentrate leuko stromal vascular cells includes multi-step processing using a portable container. | 04-30-2015 |
| 20150132851 | SYSTEMS AND METHODS FOR PROCESSING CELLS - The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user. | 05-14-2015 |
| 20150322399 | SYSTEM AND METHOD FOR DETACHMENT OF CELLS IN FIXED BED REACTORS - An apparatus for processing cells is disclosed. In one embodiment, a fixed bed reactor is provided for the cells, the fixed bed reactor including a portion movable from a first position corresponding to a packed condition of the fixed bed to a second position corresponding to a depacked condition of the fixed bed. Movement of the partition facilitates harvesting of the cells there from. Related apparatus, kits, methods, and systems are also disclosed. | 11-12-2015 |
| 20150353892 | METHOD OF COLLECTING CELLS - Disclosed is a method of collecting cells including the steps of: preparing a processed-bone comprising a bone extracted from a living body, a covering agent and first and second holes, wherein an outer surface of the bone is covered with the covering agent attached to the outer surface of the bone, and the first and second holes penetrate through the covering agent and the outer surface of the bone into the interior of the bone; introducing a liquid into the processed-bone from the first hole; and collecting a cell-containing liquid from the second hole. | 12-10-2015 |
| 20150368619 | SYSTEMS AND METHODS OF DISSOCIATING AGGREGATE SPHERES OF CELLS - Various implementations include systems and methods for automatically and continuously dissociating spheres of cells. In particular, one such system includes a peristaltic pump in fluid communication via tubing with a bioreactor in which cells are cultivated. A plurality of concentrically-arranged conduits are disposed within a portion of the tubing such that fluid flowing between the bioreactor and the pump passes through the conduits. The conduits have an inner diameter that is sized to provide a shear stress to the fluid of between about 5 to about 60 dynes/cm | 12-24-2015 |
| 20160024450 | Systems and Methods for Tissue Processing and Preparation of Cell Suspension Therefrom - The present invention provides for methods and at least partially automated devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. Tissue regeneration in humans is extremely limited and constitutes a major challenge to the repair of damaged organ function. Wound treatment is a typical area where tissue regeneration is required. Wounds (lacerations or openings) in mammalian tissue can result in tissue disruption and coagulation of the microvasculature at the wound face. | 01-28-2016 |
| 20160083691 | SYSTEMS AND METHODS FOR PROCESSING CELLS - The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user. | 03-24-2016 |
| 20160160172 | TISSUE PROCESSING APPARATUS AND METHOD FOR PROCESSING ADIPOSE TISSUE - A method for processing biological material containing stringy tissue in a container having a tissue collector disposed in a tissue retention volume on one side of an internal filter includes washing biological material contained in the tissue retention volume with wash liquid to the tissue retention volume and allowing the wash liquid and rotating the tissue collector disposed in the tissue retention volume relative to the container in a first direction of rotation about an axis of rotation to sweep the teeth positioned on the tissue collector through the biological material and to collect stringy material on the tissue collector. | 06-09-2016 |
