| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435221000 | Bacteria is bacillus | 64 |
| 20080227175 | Protease Crystals in Broth - A method of solubilizing protease crystals and/or protease precipitate in a fermentation broth comprising | 09-18-2008 |
| 20090162917 | Subtilism Carlsberg Proteins With Reduced Immunogencity - The present invention provides methods for the identification of CD4 | 06-25-2009 |
| 20090203111 | SUBTILASES - The present invention relates to methods for producing variants of a parent JP170 subtilase and of a parent BPN′ subtilase and to JP170 and BPN′ variants having altered properties as compared to the parent JP170/BPN′ subtilase. | 08-13-2009 |
| 20100196990 | PROTEASE VARIANTS - The present invention relates to methods for producing variants of a parent RP-II protease and the variants having altered properties as compared to the parent RP-II protease. | 08-05-2010 |
| 20100261252 | METHODS OF ENHANCING YIELD OF ACTIVE IGA PROTEASE - The present disclosure relates in general to methods for recombinantly producing soluble, active IgA proteases (e.g., IgA1 proteases) in host cells (e.g., bacterial cells), and methods for using IgA proteases (e.g., IgA1 proteases) produced by the methods to treat IgA deposition disorders (e.g., IgA nephropathy). | 10-14-2010 |
| 20100279383 | Subtilases and subtilase variants having altered immunogenicity - The present invention relates to subtilase variants and subtilases with an altered immunogenicity, particularly subtilase variants and subtilases with a reduced allergenecity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products. | 11-04-2010 |
| 20110045571 | Proteases With Modified Pro Regions - The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified proteases, which have at least one mutation in the pro region; the modified serine proteases encoded by the modified polynucleotides; expression cassettes, DNA constructs, and vectors comprising the modified polynucleotides that encode the modified proteases; and the bacterial host cells transformed with the vectors of the invention. The methods include methods for enhancing the production of mature proteases in bacterial host cells e.g. | 02-24-2011 |
| 20110059511 | SUBTILASES - The present invention relates to novel subtilases from wild-type strains of | 03-10-2011 |
| 20110104786 | USE AND PRODUCTION OF NEUTRAL METALLOPROTEASES IN A SERINE PROTEASE-FREE BACKGROUND - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme in the relative absence of serine protease enzyme contaminants. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and composi-tions comprising | 05-05-2011 |
| 20110171718 | Proteases With Modified Pre-Pro Regions - The invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the modified polynucleotides comprise one or more mutations that encode modified proteases having modifications of the pre-pro region that enhance the production of the active enzyme. The present invention further relates to methods for altering the production of proteases in microorganisms, such as | 07-14-2011 |
| 20110256609 | Compositions And Methods Comprising Variant Microbial Proteases - The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications. | 10-20-2011 |
| 20110262999 | Compositions and Methods Comprising Protease Variants - The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions. | 10-27-2011 |
| 20110281328 | Compositions and Methods Comprising A Subtilisin Variant - The present invention provides a | 11-17-2011 |
| 20120003718 | Protease Comprising One Or More Combinable Mutations - The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided. | 01-05-2012 |
| 20120107907 | THERMOSTABLE NEUTRAL METALLOPROTEASES - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from | 05-03-2012 |
| 20130029402 | BACILLUS STRAIN FOR INCREASED PROTEIN PRODUCTION - The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified | 01-31-2013 |
| 20130045524 | Subtilases - The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry or an automatic dishwashing detergent. | 02-21-2013 |
| 20130157341 | Multiply-Substituted Protease Variants - Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue equivalent to positions 7, 23, 26, 28, 29, 30, 31, 47, 66, 69, 73, 82, 85, 88, 90, 92, 93, 105, 113, 139, 148, 149, 150, 151, 178, 200, 201, 231, 233, 267 and/or 273 of | 06-20-2013 |
| 20130171717 | Multiply-Substituted Protease Variants - Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of | 07-04-2013 |
| 20130196415 | MICROORGANISM BELONGING TO GENUS BACILLUS, THROMBOLYTIC ENZYME, AND METHOD FOR TREATING WASTE - A microorganism belonging to the genus | 08-01-2013 |
| 20130260438 | COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS (AS AMENDED) - The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants. | 10-03-2013 |
| 20140099698 | THERMOLYSIN VARIANTS AND DETERGENT COMPOSITIONS THEREWITH - The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. | 04-10-2014 |
| 20140154782 | Compositions and Methods Comprising Serine Protease Variants - The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants. | 06-05-2014 |
| 20140186922 | PROTEASES PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME - The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins. | 07-03-2014 |
| 20140295526 | MODIFIED PROTEASES - This invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the present invention relates to methods for altering the expression of proteases in microorganisms, such as | 10-02-2014 |
| 20150056681 | Method for Improving Solubility of Alkaline Protease - Providing an alkaline protease exhibiting an improved solubility in a liquid detergent. A mutant alkaline protease consisting of the amino acid sequence represented by SEQ ID No: 2 or an amino acid sequence having 80% or more sequence identity therewith, in which at least one amino acid residue selected from the group consisting of the amino acid residues at predetermined positions of the amino acid sequence represented by SEQ ID No: 2 or corresponding positions thereto are substituted. | 02-26-2015 |
| 20150056682 | Compositions and Methods Comprising Variant Microbial Proteases - The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant proteases suitable for laundry cleaning applications. | 02-26-2015 |
| 20150064767 | COMPOSITIONS AND METHODS COMPRISING VARIANT MICROBIAL PROTEASES - The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications. | 03-05-2015 |
| 20160032266 | PRODUCTION OF THERMOLYSIN AND VARIANTS THEREOF AND USE IN LIQUID DETERGENTS - The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. | 02-04-2016 |
| 20160039874 | REGULATING BACILLUS ANTHRACIS LETHAL FACTOR ACTIVITY VIA AN ACTIVATING EPITOPE REGION - Provided are peptides capable of reducing the ability of antibodies to stimulate the activity of | 02-11-2016 |
| 20160040147 | Proteases With Modified Pro Regions - The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified proteases, which have at least one mutation in the pro region; the modified serine proteases encoded by the modified polynucleotides; expression cassettes, DNA constructs, and vectors comprising the modified polynucleotides that encode the modified proteases; and the bacterial host cells transformed with the vectors of the invention. The methods include methods for enhancing the production of mature proteases in bacterial host cells e.g. | 02-11-2016 |
| 20160083710 | COMPOSITIONS AND METHODS COMPRISING PROTEASE VARIANTS - The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions. | 03-24-2016 |
| 20160108387 | NOVEL METALLOPROTEASES - Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof. | 04-21-2016 |
| 20160108388 | NOVEL METALLOPROTEASES - Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof. | 04-21-2016 |
| 20160152963 | Protease Variants and Polynucleotides Encoding Same | 06-02-2016 |
| 20170233710 | SERINE PROTEASES OF BACILLUS SPECIES | 08-17-2017 |
| 20180023069 | PROTEASE VARIANTS HAVING AN IMPROVED WASHING PERFORMANCE | 01-25-2018 |
| 435222000 | Bacillus subtilus or bacillus lichenoformis | 27 |
| 20090011489 | MULTIPLY-SUBSTITUTED PROTEASE VARIANTS - Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease, Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of | 01-08-2009 |
| 20100196991 | NOVEL PROTEIN VARIANTS BY CIRCULAR PERMUTATION - The present invention relates to a method for obtaining novel protein variants by circular permutation, and to the novel protein variants obtained by said method. | 08-05-2010 |
| 20110003364 | SUBTILASES - The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase. | 01-06-2011 |
| 20110045572 | PROTEIN VARIANTS HAVING MODIFIED IMMUNOGENICITY - The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 Å from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant. | 02-24-2011 |
| 20110097783 | Proteases from gram-positive organisms - The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for | 04-28-2011 |
| 20110097784 | THERMOSTABLE ORGANIC SOLVENT TOLERANT PROTEASE FROM GRAM-POSITIVE BACTERIA - The present invention relates to a thermostable protease useful as an enzyme for industrial use, a gene encoding the same and a method of producing the enzyme by genetic engineering technique. More particularly, the present invention discloses a thermostable organic solvent tolerant protease and its code gene and application. The invention also discloses a method for preparing protease by isolating from | 04-28-2011 |
| 20110256610 | Compositions And Methods Comprising Variant Microbial Proteases - The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant proteases suitable for laundry cleaning applications. | 10-20-2011 |
| 20120009651 | Production of Thermolysin and Variants Thereof and Use In Liquid Detergents - The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. | 01-12-2012 |
| 20120142076 | BACILLUS STRAIN FOR INCREASED PROTEIN PRODUCTION - The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified | 06-07-2012 |
| 20120295331 | Savinase Variants Having An Improved Wash Performance on Egg Stains - Subtilase variants having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. | 11-22-2012 |
| 20130017592 | CRYSTAL METABOLITE RECOVERYAANM Pind; Peter FrodeAACI HerlevAACO DKAAGP Pind; Peter Frode Herlev DKAANM Glanville; SimonAACI KalundborgAACO DKAAGP Glanville; Simon Kalundborg DKAANM Jakobsen; SuneAACI VaerloeseAACO DKAAGP Jakobsen; Sune Vaerloese DKAANM Kaasgaard; SvendAACI SkovlundeAACO DKAAGP Kaasgaard; Svend Skovlunde DK - A method for producing a crystalline and/or amorphous metabolite suspension from a cell fermentation broth in a continuous centrifuge process comprising (a) adding at a separate inlet to the centrifuge the fermentation broth comprising the cells and the metabolite of interest, wherein the metabolite is partly or wholly on crystalline and/or amorphous form; (b) adding at another inlet to the centrifuge an aqueous liquid comprising a salt and/or a carbohydrate having a higher density than the cells and a lower density than the metabolite of interest in its precipitated form; (c) removing the cells at a separate outlet to the centrifuge; and (d) removing the suspension comprising the crystalline and/or amorphous metabolite of interest at another outlet to the centrifuge. | 01-17-2013 |
| 20130102052 | MODIFIED SECRETION SYSTEM TO INCREASE EXPRESSION OF POLYPEPTIDES IN BACTERIA - The present invention provides methods of altering the production of desired polypeptides in a host cell. In particular, the present invention provides polynucleotides encoding truncated SecG proteins capable of facilitating the secretion of desired proteases by a bacterial host cell, such as | 04-25-2013 |
| 20130122571 | Subtilases - The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase. | 05-16-2013 |
| 20130323816 | Protease Variants Active over a Broad Temperature Range - The present invention provides protease compositions particularly suited for dishwashing applications. | 12-05-2013 |
| 20130344568 | Subtilases - The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase. | 12-26-2013 |
| 20140295527 | COMPOSITIONS AND METHODS COMPRISING A SUBTILISIN VARIANT - The present invention provides a | 10-02-2014 |
| 20140302590 | Protease Variants Active over a Broad Temperature Range - The present invention provides protease compositions particularly suited for dishwashing applications. | 10-09-2014 |
| 20140335596 | Subtilase Variants and Polynucleotides Encoding Same - The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 11-13-2014 |
| 20140342433 | Subtilase Variants and Polynucleotides Encoding Same - The present invention relates to subtilase variants and methods for obtaining subtilase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 11-20-2014 |
| 20150291949 | DETERGENT COMPOSITIONS COMPRISING SUBTILASE VARIANTS - detergent compositions comprising subtilase variants and methods for obtaining such detergent compositions are provided herein. The detergent compositions further may be used, especially in laundry or in hard surface cleaning applications. | 10-15-2015 |
| 20150337283 | Subtilase Variants - The present invention relates to novel subtilase variants exhibiting improvements relative to the parent subtilase in one or more properties including: wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. | 11-26-2015 |
| 20160010073 | Subtilases | 01-14-2016 |
| 20160053248 | SYSTEMS AND METHODS FOR EVOLVING ENZYMES WITH DESIRED ACTIVITIES - The present invention provides a new method for engineering or evolving enzymes to have desirable characteristics. Among the desirable characteristics is the ability to control catalytic activity through the use of a trigger molecule that rescues a catalytic site defect introduced during the engineering process. The method includes co-evolving enzyme and substrate to retain or improve substrate binding activity in the absence of catalytic activity. | 02-25-2016 |
| 20160145594 | Protease Variants and Polynucleotides Encoding Same - The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 05-26-2016 |
| 20160145595 | Subtilase Variants and Polynucleotides Encoding Same - The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention. | 05-26-2016 |
| 20160145596 | Subtilase Variants and Polynucleotides Encoding Same - The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention. | 05-26-2016 |
| 20170233709 | Subtilases | 08-17-2017 |
