| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435201000 |
Acting on alpha-1, 4-glucosidic bond, (e.g., hyaluronidase, invertase, amylase, etc. (some 3.2.1))
| 88 |
| 435209000 |
Acting on beta-1, 4-glucosidic bond (e.g., cellulase, etc. (3.2.1.4))
| 80 |
| 435206000 |
Acting on beta-1, 4 link between N-acetylmuramic acid and 2-acetylamino 2 deoxy-D-glucose (e.g., lysozyme, etc.)
| 8 |
| 435207000 |
Acting on beta-galatose-glycoside bond (e.g., beta-galactosidase, etc.)
| 6 |
| 435210000 |
Acting on alpha-1, 6-glucosidic bond (e.g., isoamylase, pullulanase, etc.) | 4 |
| 20080227174 | Starch Debranching Enzymes - The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to the parent enzyme, to methods for producing such starch debranching enzyme variants with improved thermostability and/or altered substrate specificity, and to a method for converting starch to one or more sugars using at least one such enzyme variant. | 09-18-2008 |
| 20090075356 | Pullulanase Variants and Methods for Preparing Such Variants With Predetermined Properties - The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity, increased specific activity or altered cleavage pattern. | 03-19-2009 |
| 20110281326 | PULLULANASE VARIANTS WITH INCREASED PRODUCTIVITY - The invention relates to novel variants of the enzymatic peptide pullulanase, the gene sequences encoding said novel peptides, expression vectors comprising those gene sequences as well as organisms expressing the novel pullulanase variants. The novel pullulanase variants of the present invention were made empirically by the use of codon-optimization procedures, selective truncation of “wild-type” molecules and through the replacement of selected amino acid residues. Furthermore, the invention relates to the use of these novel pullulanase peptides in the textile, fermentation, food and other industries. | 11-17-2011 |
| 20160194620 | METHOD FOR DESIGNING MUTATED ENZYME, METHOD FOR PREPARING THE SAME, AND MUTATED ENZYME | 07-07-2016 |
| 435208000 |
Acting on alpha-galatose-glycoside bond (e.g., alpha-galactosidase, etc.) | 3 |
| 20100273235 | STABILIZED AQUEOUS ALPHA-GALACTOSIDASE COMPOSITION AND METHODS RELATING THERETO - The present invention provides an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase. The present invention further provides a method of stabilizing an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase, and a method of preparing a purified aqueous composition comprising the protein with enzymatic activity of alpha-galactosidase. | 10-28-2010 |
| 20110045569 | ENZYMATIC CONVERSION OF BLOOD GROUP A, B, AND AB RED BLOOD CELLS USING ALPHA-N- ACETYLGALACTOSAMINIDASES AND ALPHA-GALACTOSIDASES WITH UNIQUE SUBSTRATE SPECIFICITIES AND KINETIC PROPERTIES - This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique α-N-acetylgalactosaminidases and α-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant K | 02-24-2011 |
| 20160040146 | Purification of Recombinant alpha Galactosidase A - In one embodiment, the invention provides a method of purifying recombinant alpha-galactosidase A. The method includes obtaining a lysate from cells recombinantly expressing alpha-galactosidase A grown in a cell culture medium having non-precipitating phosphate; contacting said lysate with a first chromatography media that binds α-D-mannopyranosyl or α-D-glucopyranosyl; eluting alpha-galactosidase A from the first chromatography media to generate a first eluate having alpha-galactosidase A, wherein said eluting includes at least one elution pause between 4 and 16 hours; contacting the first eluate with a second chromatography media that binds galactose binding proteins; and eluting alpha-galactosidase A from said second chromatography media to generate a second eluate containing said recombinant alpha-galactosidase A. | 02-11-2016 |
| Entries |
| Document | Title | Date |
|---|
| 20080199937 | Reagent Composition and Methods of Using and Forming the Same - A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator For example, the biosensor is useful in the amperometric determination of glucose. | 08-21-2008 |
| 20080311642 | Methods of Purifying Chondroitinase and Stable Formulations Thereof - An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase. | 12-18-2008 |
| 20080318297 | Inhibition of Infiltration, and Cell Killing Agent - As suppressor of binding between selectin binding sugar chain and selectin or cell killing agent, (1) siRNA suppressing expression of genes which relates to cell surface antigen CD43 and selectin ligand sugar chain by RNA interference; (2) an inhibitor of sugar chain synthesis such as analogue of substrates in sugar chain synthesis; (3) an enzyme severing cell surface antigen CD43 and selectin ligand sugar chain; and (4) antibodies of cell surface antigen CD43 and selectin ligand sugar chain are used to selectin ligand sugar chain expressed in cell surface antigen CD43 to provide a suppressor of infiltration which is able to suppression of infiltration to tissues by leukocytes and a method of suppression thereof, and a cell killing agent of CD43 expressing cell and a cell killing method thereof. | 12-25-2008 |
| 20090148923 | MODIFICATION OF XYLANASES TO INCREASE THERMOPHILICITY, THERMOSTABILITY AND ALKALOPHILICITY - A modified Family 11 xylanase enzyme comprising cysteine residues at positions 99 and 118 to form an intramolecular disulfide bond is provided. The modified xylanase is produced by substitution of an amino acid at position 99, 118 or both positions 99 and 118 with a cysteine to produce the intramolecular disulfide bond. Xylanases of the invention display improved thermophilicity, alkalophilicity or thermostability relative to wild-type xylanases. Such xylanases find use in a variety of applications in industry that require enzyme activities at temperatures and/or pH values above that of the native enzyme. | 06-11-2009 |
| 20090176291 | LAUNDRY DETERGENT COMPOSITION COMPRISING A GLYCOSYL HYDROLASE AND A BENEFIT AGENT CONTAINING DELIVERY PARTICLE - The present invention relates to a laundry detergent composition comprising a glycosyl hydrolase and a benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. | 07-09-2009 |
| 20090181444 | MODIFIED CARBOHYDRATE PROCESSING ENZYME - A modified polypeptide having carbohydrate processing enzymatic activity is provided, said polypeptide comprising an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO:2 comprising a mutation in at least one of W433, E432 and M439; (b) the amino acid sequence of an enzyme of glycosyl hydrolase family 1, comprising at least one mutation at an amino acid residue equivalent to W433, E432 or M439 of SEQ ID NO:2; and (c) a variant of (a) or (b) having carbohydrate processing enzymatic activity and comprising at least one amino acid mutation at a position equivalent to W433, E432 or M439 of SEQ ID NO:2. | 07-16-2009 |
| 20090203106 | GALACTANASE VARIANTS - The present invention relates to variants of Glycoside Hydrolase family 53 galactanases, e.g., variants of the galactanases from strains of | 08-13-2009 |
| 20090275104 | Bacillus licheniformis chromosone - The present invention relates to an isolated polynucleotide of the complete chromosome of | 11-05-2009 |
| 20090325267 | Modified xylanases exhibiting increased thermophilicity and alkalophilicity - The present invention pertains to modified xylanase enzymes that exhibit increased thermostability and alkalophilicity, when compared with their native counterparts. Several modified xylanases exhibiting these properties are disclosed including xylanases with at least one modification at amino acid position 10, 27, 29, 75, 104, 105, 125, 129, 132, 135, 144, 157, 161, 162 or 165, or a combination thereof. Also included within the present invention is a modified xylanase that comprises at least one substituted amino acid residue and that may be characterized as having a maximum effective temperature (MET) between about 69° C. and about 78° C., wherein the modified xylanase is a Family 11 xylanase obtained from a | 12-31-2009 |
| 20100009425 | Glycoprotein synthesis - Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars. | 01-14-2010 |
| 20100159562 | FUNGUS-INDUCED INFLAMMATION AND EOSINOPHIL DEGRANULATION - This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation, methods for assessing eosinophil degranulation, and methods for identifying inhibitors of fungus-induced inflammation and/or eosinophil degranulation are provided. | 06-24-2010 |
| 20100173385 | METHODS FOR INTRODUCING MANNOSE 6-PHOSPHATE AND OTHER OLIGOSACCHARIDES ONTO GLYCOPROTEINS AND ITS APPLICATION THEREOF - Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase uptake by cell surface receptor-mediated mechanisms, thus improving their therapeutic efficacy in a variety of applications. | 07-08-2010 |
| 20100221810 | NOVEL DIGLYCOSIDASE AND GENE ENCODING THE SAME - A novel diglycosidase produced by a microorganism belonging to the genus | 09-02-2010 |
| 20100267114 | Glucoamylase Variants with Altered Properties - The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. | 10-21-2010 |
| 20100279382 | COMPOSITIONS AND METHODS FOR QUANTIFICATION OF SERUM GLYCOPROTEINS - The invention provides compositions and methods for identifying and/or quantifying glycopolypeptides from human serum or plasma. The compositions and methods include a plurality of standard peptides containing glycosylation sites determined for human serum/plasma proteins. | 11-04-2010 |
| 20100317083 | METHODS AND KITS FOR DISSOCIATING FCGAMMA-RECEPTOR-IGG COMPLEXES AND FOR IGG PURIFICATION AND DETECTION - The inventions provides methods and kits for the dissociation of Fcγ-receptor-IgG complexes, and methods and kits for the isolation of IgG and Fc and Fab fragments of IgG. | 12-16-2010 |
| 20110039325 | FAMILY 8 ENZYMES WITH XYLANOLYTIC ACTIVITY - The present invention describes a method to improve the properties of a dough and/or a baked product by adding a bread or dough-improving agent containing a enzyme with xylanolytic activity belonging to glycoside hydrolases family 8. Preferred enzymes are the psychrophilic xylanase from | 02-17-2011 |
| 20110059509 | Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 03-10-2011 |
| 20110183401 | Kappa-Carrageenase And Kappa-Carrageenase-Containing Compositions - The present invention provides cleaning compositions comprising at least one carrageenase enzyme, methods for producing carrageenase enzymes in host cells, host cells comprising recombinant polynucleotides encoding at least one carrageenase, and recombinant polynucleotides encoding carrageenase. | 07-28-2011 |
| 20110207200 | Pseudomonas sp. strain and method of producing chitinase, chitosanase and nattokinase using the same | 08-25-2011 |
| 20110236954 | CELLULASE PRODUCTION METHOD BASED ON THE REGULATION OF THE DISSOLVED OXYGEN PRESSURE OSCILLATION IN THE CULTURE MEDIUM - The present invention relates to a method of producing cellulolytic and/or hemicellulolytic enzymes by a cellulolytic microorganism in a stirred and aerated bioreactor, comprising a growth stage in the presence of a carbon source and a production stage in the presence of a carbon-containing inductive substrate, wherein the supply of carbon-containing inductive substrate during the production stage is regulated by an oscillation of the dissolved oxygen partial pressure in the medium. | 09-29-2011 |
| 20110287515 | PROTEIN AND DNA SEQUENCE ENCODING A COLD ADAPTED XYLANASE - A method of preparing a cold adapted xylanase by use of recombinant DNA techniques. A nucleic acid and corresponding amino acid sequences of a cold adapted xylanase, isolated from antarctic marine origin, preferably from an Antarctic bacteria ( | 11-24-2011 |
| 20110312058 | POLYPEPTIDES WITH XYLANASE ACTIVITY, - Polypeptides with xylanase activity modified to increase bran solubilisation and/or xylanase activity. The modification comprises at least an amino acid modification i position 110 and may have further modifications of one or more amino acids in position 11, 12, 13, 34, 54, 77, 81, 99, 104, 113, 114, 118, 122, 141, 154, 159, 162, 164, 166 or 175 wherein the positions are determined as the position corresponding the position of | 12-22-2011 |
| 20120028334 | Polypeptides having arabinofuranosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having alpha-L-arabinofuranosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 02-02-2012 |
| 20120258519 | Protein Harvesting - Methods of harvesting proteins directly from bioreactors to avoid at several steps in the purification of recombinant drugs are disclosed. | 10-11-2012 |
| 20120288915 | MODIFIED NUCLEOTIDE MOLECULES OF XYLANASE AND APPLICATION THEREOF - Modified nucleotide molecules of xylanase and the application of the nucleotide molecules in constructing recombinant vectors, host cells or producing xylanase are disclosed, wherein the nucleotide molecules contain nucleotide sequences having greater than 80% identity with nucleotide sequence shown by SEQ ID NO: 1. | 11-15-2012 |
| 20120309074 | NOVEL XYLANASE PRODUCED FROM CELLULOSIMICROBIUM FUNKEI HY-13 - There are provided a novel xylanase and a use of the same. In detail, there are provided a xylanase separated from a | 12-06-2012 |
| 20130196412 | MAGI POLYNUCLEOTIDES, POLYPETIDES, AND ANTIBODIES - MAGI polypeptides, polynucleotides, antibodies, and methods for producing the same by recombinant techniques are disclosed. Also disclosed are methods for utilizing MAGI polypeptides and polynucleotides in diagnostic assays. | 08-01-2013 |
| 20130210118 | POLYPEPTIDES HAVING COLANIC ACID-DEGRADING ACTIVITY - The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying plasmid DNA. | 08-15-2013 |
| 20130288335 | METHOD TO IMPROVE THE STABILITY AND BROADEN THE PH RANGE OF FAMILY G/11 XYLANASES - The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns | 10-31-2013 |
| 20130309752 | Polypeptides Having Colanic Acid-Degrading Activity - The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying plasmid DNA. | 11-21-2013 |
| 20130337540 | Novel Class of Therapeutic Protein Based Molecules - The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy. | 12-19-2013 |
| 20130337541 | THERMOSTABLE CHITOSANASE - The present application concerns a thermostable chitosanase, originally identified in | 12-19-2013 |
| 20140212948 | XYLANASE COMPOSITION WITH INCREASED STABILITY - A xylanase composition and a method for manufacturing the xylanase composition are provided, wherein the xylanase composition comprises a xylanase and a stabilizer, and the xylanase is from an anaerobic fungus, the stabilizer comprises a polyol, and the content of the polyol is at least 40 wt %, based on the total weight of the xylanase composition. | 07-31-2014 |
| 20140256018 | BETA-GLUCOSIDASE VARIANTS - The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue. | 09-11-2014 |
| 20140315273 | BETA-MANNANASE HAVING IMPROVED ENZYMATIC ACTIVITY - A β-mannanase having increased enzymaic activity is disclosed. The β-mannanase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Tyrosine at position 216 with Tryptophan. | 10-23-2014 |
| 20140377841 | Detergent Compositions Containing Bacillus Agaradhaerens Mannanase and Methods of Use Thereof - The present compositions and methods relate to an endo-β-mannanase cloned from | 12-25-2014 |
| 20150024466 | POLYPEPTIDES WITH XYLANASE ACTIVITY - The present invention relates to polypeptides with xylanase activity and uses thereof. The present invention also relates to method of modifying polypeptides with xylanase activity to affect, preferably to increase, xylanase activity and/or bran solubility. | 01-22-2015 |
| 20150031112 | Crystal structure of human alpha-n-acetylglucosaminidase - The present invention provides the three-dimensional structure of human α-N-acetylglucosaminidase (NAGLU) protein. This crystallographic information is useful in the identification and development of novel binding compounds of NAGLU, NAGLU mutants, for example, those associated with Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)), and other NAGLU family members (family 89 α-N-acetylglucosaminidase) which may modulate the activity and/or stability of mutated NAGLU. Such compounds may be useful for the treatment of Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)). | 01-29-2015 |
| 20150132822 | Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 05-14-2015 |
| 20160032301 | GUARD CELL EXPRESSION CASSETTES COMPOSITIONS AND METHODS OF USE THEREOF - The invention is directed to artificial transcription regulating polynucleotides that confer guard cell regulated expression and methods of use thereof. The present invention further provides methods of using the transcription regulating polynucleotides and plants and plant parts thereof comprising the transcription regulating polynucleotides. In agricultural biotechnology, plants can be modified according to one's needs. One way to accomplish this is by using modern genetic engineering techniques. For example, by introducing a gene of interest into a plant, the plant can be specifically modified to express a desirable phenotypic trait. | 02-04-2016 |
| 20160122726 | INFLUENZA VIRUS REASSORTMENT - The invention provides reassortant influenza strains. | 05-05-2016 |
| 20160130626 | Expression of Natively Secreted Polypeptides Without Signal Peptide - The present invention relates to methods of recombinantly producing a natively secreted polypeptide, the method comprising the steps of providing a microorganism host cell comprising an exogenous polynucleotide encoding a natively secreted polypeptide without a translationally fused signal peptide; cultivating the microorganism host cell under conditions conducive to the expression of the polypeptide and, optionally, recovering the polypeptide, as well as microorganisms, certain polynucleotides, expression constructs and protease substitution variants. | 05-12-2016 |
| 20160137997 | APPARATUS AND METHOD FOR DEHYDRATING BIOLOGICAL MATERIALS - An apparatus and method for microwave vacuum-drying of temperature-sensitive biological materials on a continuous flow-through basis, in which the materials are frozen, ground to frozen particles, dehydrated to a powder, and the powder collected. The apparatus has a microwave generator and waveguide, a freezing chamber with a grinder, a rotatable dehydration chamber in or adjacent to the waveguide, and a powder collector to receive the powdered biological material. The apparatus operates under reduced pressure provided by a vacuum system coupled to the powder collector. | 05-19-2016 |
| 20160168555 | MUTANT XYLANASE, MANUFACTURING METHOD AND USE THEREFOR, AND METHOD FOR MANUFACTURING SACCHARIFIED LIGNOCELLULOSE | 06-16-2016 |
