Class / Patent application number | Description | Number of patent applications / Date published |
435126000 | Containing five-membered hetero ring (e.g., griseofulvin, etc.) | 63 |
20080199922 | Chemoenzymatic Process for the Synthesis of Escitalopram - A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of the formula (IV) where R represents a C | 08-21-2008 |
20080227163 | Production of L-ribose and other rare sugars - The invention provides methods and compositions for the production of | 09-18-2008 |
20080227164 | Process For Producing Mycophenolic Acid Using Penicillium Arenicola Bicc 7673 - The present invention discloses the manufacture of MPA by fermentation under optimal fermentation parameters using a new strain of | 09-18-2008 |
20080274520 | Novel Gene Sms 37 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 11-06-2008 |
20080293110 | Process for Isolation of Mycophenolic Acid - Mycophenolic acid can be isolated from fermentation broth easily with low consumption or organic solvents to produce mycophenolic acid that is surprisingly high in purity. The process can be accomplished by addition of a suitable base to the whole fermentation broth. i.e., a suspension obtained by submerged cultivation of a microorganism producing mycophenolic acid, to increase pH of the liquid phase to the value from about (9) to about (13). Mycophenolic acid is thus extracted from the mycelium to the liquid phase and the exhausted mycelium can be separated easily by filtration. | 11-27-2008 |
20090023191 | Gene RCS 23 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 01-22-2009 |
20090053780 | Enzymatic oxidation of HMF - A method of converting hydroxymethylfurfural and is derivative species into hydroxymethylfurfural oxidation products is disclosed. The method includes contacting the hydroxymethylfurfural species in a mixture with an enzyme that oxidizes the hydroxymethylfurfural species while controlling hydrogen peroxide in the mixture. In one exemplary embodiment the enzyme is chloroperoxidase and the hydrogen peroxide is metered into the mixture to predominantly and selectively make at least one of formylfuran carboxylic acid or furan dicarboxylic acid. In another embodiment the enzyme is aryl alcohol oxidase and catalase is included in the mixture to remove unwanted hydrogen peroxide by product and the reaction predominantly makes at least one of dimethylfuran or formylfuran carboxylic acid. When the predominant product is a carboxylic acid or furan dicarboxylic acid, it can be recovered in substantially pure form by acid precipitation. | 02-26-2009 |
20090104669 | Method for Preparing (S)-3-Hydroxy-Gamma-Butyrolactone Using Hydrolase - The present invention relates to a method for preparing S-HGB ((S)-3-hydroxy-γ-butyrolactone) using hydrolase, and more particularly to a method for preparing S-HGB in a high purity by hydrolyzing S-BBL ((S)-β-benzoyloxy-γ-butyrolactone) in the presence of hydrolase. According to the present invention, the S-HGB having an optical purity can be obtained in a high yield under simple process conditions without requiring reaction conditions of high pressure and high temperature or complex operating conditions by hydrolyzing S-BBL with hydrolase. | 04-23-2009 |
20090130725 | Gene Sms 14 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 05-21-2009 |
20090137012 | Process for producing lactonase and utilitzation thereof - It has been required to economically produce a large amount of optically active γ-lactone derivatives (for example, pantolactone), which are useful as intermediates in synthesizing useful substances such as pharmaceutical drugs. To achieve this object, it is advantageous to employ an enzymatic technique of asymmetric hydrolysis with a hydrolyzing enzyme lactonase. However, it remains troublesome to prepare the enzyme or utilize a microorganism capable of producing the enzyme. Also, it is difficult to obtain a sufficient and stable enzymatic activity in the case of using recombination techniques. In producing lactonase, which asymmetrically hydrolyzes a γ-lactone derivative such as racemic pantolactone selectively, by a recombination technique, both mature lactonase DNA and signal peptide region DNA are transferred into a host. Thus, a stable lactonase activity comparable to naturally-occurring one can be achieved and a transformant sustaining a high enzyme activity in a stable manner can be acquired, thereby allowing the efficient and industrially advantageous asymmetric synthesis of γ-lactone derivatives. | 05-28-2009 |
20090142815 | Gene SMS 05 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 06-04-2009 |
20090215135 | Novel Gene STS 22 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 08-27-2009 |
20100203598 | MICROBIAL PRODUCTION OF L-ASCORBIC ACID - The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps. | 08-12-2010 |
20100209979 | Method of Manufacturing Glycerol Carbonate - Disclosed is a method of manufacturing a glycerol carbonate (GC). The method includes a bio-catalyst reaction for generating the GC and byproducts generated by reacting a reactant solution using a lipase of a bio-catalyst. In this instance, the reactant solution is prepared by adding glycerol, a glycerol-containing composition, or a dimethyl carbonate (DMC) in a reaction solvent. | 08-19-2010 |
20100233766 | Novel Microorganism and Method for Producing Dodecahydro-3a,6,6,9a-Tetramethylnaphtho[2,1-b]Furan Intermediate Using the Novel Microorganism - This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present invention belongs to Ascomycetes and has the ability of producing a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. Such microorganism of Ascomycetes represents a new finding and it can be effective for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan and an intermediate thereof. | 09-16-2010 |
20100248315 | Fermentative vitamin C production - The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 09-30-2010 |
20100248316 | Process for the Production of Ambrafuran - A method for the cyclodehydration of a 1,4- or 1,5-diol includes the step of exposing a 1,4- or a 1,5-diol to an activated zeolite at a temperature of between about 0° C. and about 110° C. for a period of between about 1 and 24 hours. The activated zeolite is prepared from an inactive NaY or CaY type zeolite by ion exchange with an ammonium salt, to produce an ammonium zeolite and exchange of at least part of the ammonia of the ammonium zeolate with a group II A metal. | 09-30-2010 |
20100255549 | MICROBIAL PRODUCTION OF 3-HYDROXYACIDS FROM GLUCOSE AND GLYCOLATE - The invention relates to recombinant cells and their use in the production of 3-hydroxyacids such as 3,4-dihydroxybutyrate and 3-hydroxybutyrolactone. | 10-07-2010 |
20100285543 | Novel Endophytic Fungi And Methods Of Use - This invention provides a novel endophytic fungus, | 11-11-2010 |
20100317070 | COMPLETE LIQUEFICATION OF LIGNOCELLULOSIC AGROWASTE TO FORM LIQUID BIOFUELS - A process for converting lignocellulosic materials which are field residues such as cotton stalks and corn stover, process residues such as sugarcane bagasse and sweet sorghum bagasse, woody parts of energy crops such as switchgrass and miscanthus, forest residues or byproducts of the wood processing industries such as sawdust from sawmills to a liquid biofuel by a series of processing steps wherein the feed materials are hydrolysed in three stages and withdrawn as three product streams each consisting of solubilized fragments of one of the three major components of the feed materials and a set of concurrently operating processing steps wherein each of the three product streams is transformed through chemical or biochemical processes into products, such as pure lignin and ethanol, that have a high calorific value and process wherein these products with high calorific value are combined to form a liquid biofuel. | 12-16-2010 |
20100323412 | NOVEL GENE SMS 44 - The present invention relates to novel genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to modified proteins and polynucleotides encoding said modified proteins as well as to modified microorganisms, wherein the modification has a direct or indirect impact on yield, production, and/or efficiency of production of Vitamin C and/or 2-KGA in said microorganisms. Also included are processes of using the modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C and/or 2-KGA. | 12-23-2010 |
20110045552 | NOVEL GENE SMS 43 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechno logical tools in the production of Vitamin C and/or 2-KGA from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C and/or 2-KGA. | 02-24-2011 |
20110165635 | METHODS AND MATERIALS FOR PROCESSING A FEEDSTOCK - The present disclosure relates generally to methods for processing a feedstock. Specifically, methods are provided for processing a feedstock by mixing the feedstock with an additive organism that comprises one or more transgenes coding for one or more enzymes. The expressed enzymes may be capable of breaking down cellulosic and lignocellulosic materials and converting them to a biofuel. | 07-07-2011 |
20110217742 | MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE - The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL. | 09-08-2011 |
20110229942 | Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals - Microorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the FadR enzyme activity is partially or substantially eliminated and a mutation in an atoC gene that provides overexpression of the microorganism's ato operon. Methods of using the microorganisms to produce high-value chemicals are also provided. The high-value chemicals include ethanol, methyl acetate, succinate, gamma-butyrolactone, 1,4-butanediol, acetone, iso-propanol, butyrate, butanol, mevalonate, propionate, ethanolamine and 1,2-propanediol. | 09-22-2011 |
20110229943 | METHODS FOR CONVERTING GLUCOSE TO ASCORBIC ACID - Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described. | 09-22-2011 |
20110244531 | SYNTHESIS ROUTES TO 2(S),4(S),5(S),7(S)-2,7-DIALKYL-4-HYDROXY-5-AMINO-8-ARYL-OCTANOYL AMIDES - The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block. | 10-06-2011 |
20120009635 | Metabolically Engineered Bacterial Strains Having Non-Functional Endogenous Gluconate Transporters - The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes. | 01-12-2012 |
20120015411 | MANUFACTURE OF MALEIC ANHYDRIDE FROM RENEWABLE MATERIALS, MALEIC ANHYDRIDE OBTAINED, AND USES THEREOF - The present application relates to a process for manufacturing maleic anhydride that comprising the following steps: a) fermentation of renewable raw materials and optionally purification to produce a mixture comprising at least butanol; b) oxidation of the butanol to maleic anhydride at a temperature generally between 300° C. to 600° C., using a catalyst based on oxides of vanadium and/or molybdenum; c) isolation of the maleic anhydride obtained at the end of step b). It also relates to the maleic anhydride obtained from renewable raw materials, to the copolymers and compositions comprising said maleic anhydride and also uses of use of this maleic anhydride. | 01-19-2012 |
20120135477 | Biocatalytic Production of Ambroxan - The invention relates to a process for the biocatalytic production of ambroxan by means of a polypeptide with the activity of a homofarnesol-ambroxan cyclase, which are a novel class of enzymes. | 05-31-2012 |
20120171734 | EXTRACTION OF EXTRACELLULAR TERPENOIDS FROM MICROALGAE COLONIES - The invention provides methods of extracting and quantifying extracellular terpenoid hydrocarbons, e.g., botryococcenes, methylated squalenes, and carotenoids, from terpenoid-producing and secreting green microalgae. | 07-05-2012 |
20130011886 | METHOD FOR THE PRODUCTION OF A FERMENTATION PRODUCT FROM LIGNOCELLULOSIC FEEDSTOCKS - The present invention comprises pretreating a lignocellulosic feedstock with acid at a pH between about 2.0 and about 3.5 to produce a composition comprising an acid pretreated feedstock. The acid pretreated feedstock is then enzymatically hydrolyzed with cellulases and β-glucosidase. The glucose is fermented by microorganisms to produce a fermentation broth comprising the fermentation product, followed by recovery of the fermentation product. The steps of enzymatically hydrolyzing and fermenting are conducted at a pH below about 4.0. | 01-10-2013 |
20130034884 | MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine. | 02-07-2013 |
20130040348 | GENE ENCODING LIGNAN METHYLTRANSFERASE AND USE THEREOF - The present invention provides an enzyme having an activity of transferring a methyl group to lignans (a lignan methylation activity) (e.g., a protein comprising the amino acid sequence of SEQ ID NO:2 or variants thereof); a gene encoding the enzyme (e.g., a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 or variants thereof); a method for producing methylated lignans using the gene; and so on. | 02-14-2013 |
20130071886 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO. | 03-21-2013 |
20130143280 | FERMENTATIVE VITAMIN C PRODUCTION - The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 06-06-2013 |
20130217080 | MICROBIAL PRODUCTION OF L-ASCORBIC ACID - The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps. | 08-22-2013 |
20130252290 | DNA ENCODING PROTEIN AND METHODS OF USING SAME - The present invention relates to novel tools for improving MPA production. In particular, the present invention relates to fungal enzymes that are specific for MPA synthesis. | 09-26-2013 |
20130273618 | PREPARATION OF (3aS,7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYZED BIOLOGICAL RESOLUTION OF DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE - Processes for the synthesis of (3aS,7aR)-hexahydroisobenzofuran-1-(3H)-one, comprising comprising enzymatic hydrolysis of dimethyl cyclohexane-1,2-dicarboxylate to form (1S,2R)-2-(methoxycarbonyl) cyclohexanecarboxylic acid. The enzyme can be from a non-mammalian source. | 10-17-2013 |
20130273619 | Process for the Preparation of (3E, 7E)-Homofarnesol - The present invention relates to new types of processes for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations with an increased content of (3E,7E)-homofarnesol (also referred to as all E-homofarnesol). | 10-17-2013 |
20130330788 | BIOMASS LIQUEFACTION PROCESSES, AND USES OF SAME - Described are processes for the liquefaction of lignocellulosic biomass under the digestive action of dicarboxylic acid(s). Such digests can exhibit enhanced flowability, reduced volume, and significant biomass conversion to dissolved components, and can in some embodiments be further liquefied by contact with an enzyme. Products resultant of these steps can be used for their sugar content to manufacture biofuels or other products. | 12-12-2013 |
20140073019 | GENETICALLY MODIFIED CELL AND PROCESS FOR USE OF SAID CELL - The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention. | 03-13-2014 |
20140106414 | COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF - The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention. | 04-17-2014 |
20140162327 | MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE - The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL. | 06-12-2014 |
20140170714 | POST PROCESS PURIFICATION FOR GAMMA-BUTYROLACTONE PRODUCTION - Post purification processes and methods for making pure biobased gamma-butyrolactone from renewable carbon resources comprising filtration and/or distillation and/or peroxide treatment are described herein. | 06-19-2014 |
20140186903 | PROCESSES AND APPARATUS FOR PRODUCING FURFURAL, LEVULINIC ACID, AND OTHER SUGAR-DERIVED PRODUCTS FROM BIOMASS - In some variations, the invention provides a process for producing furfural, 5-hydroxymethylfurfural, and/or levulinic acid from cellulosic biomass, comprising: fractionating the feedstock in the presence of a solvent for lignin, sulfur dioxide, and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose contained in the liquor, to produce hemicellulosic monomers; dehydrating the hemicellulose to convert at least a portion of C | 07-03-2014 |
20140206047 | COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF - The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention. | 07-24-2014 |
20140308717 | OXIDATION AND AMINATION OF SECONDARY ALCOHOLS - The present invention relates to a method comprising the steps a) providing a secondary alcohol, b) oxidizing the secondary alcohol by contacting it with an NAD(P) | 10-16-2014 |
20140308718 | FERMENTATION PROCESS FOR PRODUCING CHEMICALS - The invention refers to a method of biotransforming a carbohydrate of a raw material into a chemical, by cultivating | 10-16-2014 |
20140349351 | Production of 5-Hydroxymethylfurfural From Fructose - The present invention relates to a process for producing 5-hydroxymethylfurfural (HMF) from fructose in a single-phase aqueous solution comprising an organic solvent. | 11-27-2014 |
20150010965 | PROCESS FOR THE PRODUCTION OF FURAN DERIVATIVES FROM GLUCOSE - A process for the production of furan derivatives from D-glucose, wherein
| 01-08-2015 |
20150056670 | MICROORGANISM PRODUCING 4-HYDROXYBUTYRATE AND A METHOD FOR PRODUCING 4-HYDROXYBUTYRATE IN ANAEROBIC CONDITION USING THE SAME - A genetically modified microorganism comprising a polynucleotide encoding α-ketoglutarate synthase or a mutant thereof, and a polynucleotide encoding pyruvate carboxylase or a mutant thereof; wherein the genetically modified microorganism has decreased malate quinone oxidoreductase activity and/or decreased phosphoenolpyruvate carboxykinase activity compared to an unmodified microorganism of the same type, and wherein the genetically modified microorganism produces 4-hydroxybutyrate. | 02-26-2015 |
20150140616 | PROCESS FOR MAKING FURFURAL - Processes are described for producing furfural from a mixture of pentoses and hexoses, by dehydrating and cyclizing pentoses to provide furfural using a water-soluble acid at elevated temperatures in the presence of a low-boiling, water-immiscible organic solvent, such as toluene, which is effective for extracting the furfural into an organic phase portion. In certain embodiments, a fermentation step occurs prior to the dehydration step to convert hexoses in the mixed pentoses and hexoses to ethanol while conserving pentoses therein for making furfural. | 05-21-2015 |
20150315166 | Esterification of 2,5-Furan-Dicarboxylic Acid - A method of making a furan dicarboxylate by means of reacting 2,5-furan dicarboxylic acid (FDCA) with an alcohol or mixture of alcohols in a CO | 11-05-2015 |
20150376659 | ENZYMES FOR PRODUCING NON-STRAIGHT-CHAIN FATTY ACIDS - Enzymes for producing non-straight-chain fatty acids, microorganisms comprising the enzymes, and in vivo and in vitro uses of the enzymes. Provided are enzymes capable of producing various non-straight-chain fatty acids, including branched-chain fatty acids, cyclic fatty acids, and furan-containing fatty acids. The enzymes include RSP2144, RSP1091, and RSP1090 from | 12-31-2015 |
20160002685 | PRIMER FOR AMPLIFYING ENONE OXIDOREDUCTASE FROM MANGO - The present invention disclosed herein the primers for amplifying enone oxidoreductase, having sequence selected from the group consisting of Seq. ID No. 1 to 13, from mango. Also disclosed herein is a novel nucleotide sequence of Sequence ID No. 14 encoding said amplified enone oxidoreductase, for enzyme production in an artificial system thus generating the desired flavor in food products. | 01-07-2016 |
20160024540 | Process and Intermediates for the Preparation of Pregabalin - The invention provides processes for the manufacture of a compound of formula (I | 01-28-2016 |
20160053287 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO. | 02-25-2016 |
20160053288 | METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL - The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO | 02-25-2016 |
20160145662 | PROCESS FOR THE PREPARATION OF 2,5-FURANDICARBOXYLIC ACID - The invention is directed to a process for the preparation of 2,5-furandicarboxylic acid (FDCA) by fermentation comprising fermenting a suitable starting compound to produce an aqueous solution of a salt of FDCA having a pH of at least 7, optionally removing solids from said solution, e.g. by filtration, subsequently freeze crystallizing the said salt of FDCA from said solution at said pH, isolating the said FDCA salt in the form of solid crystals, preparing an aqueous solution of said salt and crystallizing FDCA as the free acid from said solution at an acidic pH. | 05-26-2016 |
20160176838 | HMF PRODUCTION FROM GLUCOSE IN IONIC LIQUID MEDIA | 06-23-2016 |
20160251298 | PREPARATION OF HOMOALLYLIC COMPOUNDS BY REACTION OF CYCLOPROPYLVINYL PRECURSORS WITH BRONSTEDT ACIDS | 09-01-2016 |
20180023105 | Genetically Modified Cell and Process for Use of Said Cell | 01-25-2018 |