| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435125000 | Containing six-membered hetero ring (e.g., fluorescein, etc.) | 48 |
| 20080233618 | Biosynthetic gene cluster for leptomycins - Polypeptides and domains of leptomycin polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other polyketides using the nucleic acids encoding leptomycin polyketide synthase domains or modifying enzymes. | 09-25-2008 |
| 20080261280 | Manipulation of Genes of the Mevalonate and Isoprenoid Pathways to Create Novel Traits in Transgenic Organisms - Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants and microalgae, and (3) create a novel selection system and/or targeting sites for mediating the insertion of genetic material into plant and microalgae plastids. The specific polynucleotides to be used, solely or in any combination thereof, are publicly available from GeneBank and contain open reading frames having sequences that upon expression will produce active proteins with the following enzyme activities: (a) acetoacetyl CoA thiolase (EC 2.3.1.9), (b) 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase (EC 4.1.3.5), (c) HMG-CoA reductase (EC 1.1.1.34), (d) mevalonate kinase (EC 2.7.1.36), (e) phosphomevalonate kinase (EC 2.7.4.2), (f) mevalonate diphosphate decarboxylase (EC 4.1.1.33), (g) isopentenyl diphosphate (IPP) isomerase (EC 5.3.3.2), and (h) phytoene synthase (EC 2.5.1.32). | 10-23-2008 |
| 20080274519 | FLAVONOID CONCENTRATES - A method of producing a flavonoid aglycone concentrate from plant material containing a suitable flavonoid glycoside and/or conjugate thereof comprising the steps of:
| 11-06-2008 |
| 20080280335 | Manufacturing Method of Kaempferol - Disclosed is a kaempferol preparing method comprising isolating kaempferol from kaempferol glucosides using an acid, a base, an enzyme or a microbe producing the enzyme. More specifically, the method comprises obtaining a plant extract containing kaempferol glycosides from a plant using water or an organic solvent; and hydrolyzing the plant extract using an acid, a base, an enzyme or a microbe producing the enzyme to isolate kaempferol. The kaempferol glycosides comprise camelliaside A or camelliaside B. The plant extract is derived from a seed or leaf of green tea. When using the method of the invention, it is possible to mass-produce kaempferol, which is one of main physiological activating ingredients, from a plant, particularly a seed or leaf of green tea. | 11-13-2008 |
| 20080311634 | Flavonoids-rich tissue from Belamcanda chinensis and methods for culturing the same - The present invention provides an in vitro flavonoid-rich tissue of | 12-18-2008 |
| 20090130724 | Enzymatic Demethylation of Flavonoids - The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids. | 05-21-2009 |
| 20090148916 | PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR - The present invention relates to a protein derived from a microorganism belonging to the genus | 06-11-2009 |
| 20090191602 | Methods and Materials for Making Simvastatin and Related Compounds - The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. | 07-30-2009 |
| 20090197311 | METHOD FOR THE PRODUCTION OF SIMVASTATIN - The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process. | 08-06-2009 |
| 20090239272 | Production of flavonoids by recombinant microorganisms - Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids. | 09-24-2009 |
| 20090280543 | REGIOSELECTIVE GLYCOSYLATION - We describe a screening method for the identification of glycosyltransferase polypeptides that regioselectively modify aglycones and the use of said glycosyltransferase polypeptides to modify aglycones. | 11-12-2009 |
| 20100136636 | PROCESS FOR SELECTIVE PRODUCTION OF THEAFLAVIN - The present invention provides a method for selective production of theaflavin in large amounts at high yield, and in an easy and inexpensive manner. Specifically, it relates to a method for selective production of theaflavin whereby a processed plant extract containing epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate is combined with a plant cell culture having peroxidase activity for selective production of theaflavin. | 06-03-2010 |
| 20100184167 | METHOD FOR PRODUCING PURIFIED TEA EXTRACT - A purified tea extract is improved in taste by reducing a percentage of gallates in the non-polymer catechins. A process according to the present invention for the production of a purified tea extract includes subjecting a tea extract to a hydrolysis treatment, causing the tea extract to adsorb on the activated carbon, and then bringing a basic aqueous solution or an aqueous solution of an organic solvent into contact with the activated carbon to elute the non-polymer catechins. | 07-22-2010 |
| 20100196969 | METHOD FOR OBTAINING ENERGY-GENERATING COMPOUNDS BY MEANS OF ELECTROMAGNETIC ENERGY - The present invention relates to a process for obtaining energetic compounds by means of electromagnetic energy produced by sunlight or artificial light by means of using phytoplankton cultures. | 08-05-2010 |
| 20100279367 | Soybean-Based Fermentation Media, Methods of Making And Use - Fermentation media containing an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and at least one exogenous added ingredient that comprises a substrate for microbial growth are provided. Methods of making a fermentation medium comprising an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and methods for obtaining a fermentation product are also provided. The present invention is further directed to fermentation broths obtained by the media and methods. The present invention is also directed to feed additives produced from fermentation broths obtained by the methods. | 11-04-2010 |
| 20100330627 | ENZYME ASSOCIATED WITH EQUOL SYNTHESIS - An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. | 12-30-2010 |
| 20110033904 | METHOD FOR PREPARING ORTHODIHYDROXYISOFLAVONES USING A BIOTRANSFORMATION SYSTEM - Disclosed herein is a method for preparing ortho-dihydroxyisoflavones using a biotransformation system. More specifically, disclosed is a method for preparing ortho-dihydroxyisoflavones, which comprises biotransforming daidzein or genistein by actinomycete microorganisms, particularly | 02-10-2011 |
| 20110059493 | Methods for Making Simvastatin and Intermediates - The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention. | 03-10-2011 |
| 20110097766 | 1,2 - ADDITION OF CARBONYL COMPOUNDS USING THE ENZYME YERE - A method is disclosed for forming a covalent bond between two groups having carbonyl radicals in accordance with the present reaction equation: | 04-28-2011 |
| 20110111468 | VARIANT LOVD POLYPEPTIDES AND THEIR USES - The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound | 05-12-2011 |
| 20110223640 | IMPROVED STATIN PRODUCTION - The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin or simvastatin comprising culturing a host, preferably a filamentous fungus, comprising the polynucleotide of the lovE transcription regulator gene from | 09-15-2011 |
| 20120034661 | STRAINS FOR THE PRODUCTION OF FLAVONOIDS FROM GLUCOSE - The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI). | 02-09-2012 |
| 20120064583 | HIGH THROUGHPUT BIOPROCESS APPARATUS - The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means. The invention further relates to A method of operating a multiple bioreactor system comprising providing a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by each bioreactor or located between each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means and operating the system. | 03-15-2012 |
| 20120094336 | SYNTHESIS OF EQUOL - Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound. | 04-19-2012 |
| 20120129230 | Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same - Cells of the species | 05-24-2012 |
| 20120202256 | NOVEL PREPARATION METHOD OF HUMAN METABOLITES OF SIMVASTATIN OR LOVASTATIN USING BACTERIAL CYTOCHROME P450 AND COMPOSITION THEREFOR - A method of producing human metabolites of simvastatin or lovastatin, and more particularly, a method of producing human metabolites of simvastatin and lovastatin by using bacterial cytochrome P450 BM3(CYP102A1) or mutants thereof, and a composition and kit therefor. | 08-09-2012 |
| 20120244582 | LOV-D ACYLTRANSFERASE MEDIATED ACYLATION - Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented. | 09-27-2012 |
| 20120301931 | PROCESS FOR THE REDUCTION OF CINNAMALDEHYDE DERIVATIVE EMPLOYING ENOATE REDUCTASES - The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents. | 11-29-2012 |
| 20120315680 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS - The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. | 12-13-2012 |
| 20120315681 | Process For Producing A Monomer Component From A Genetically Modified Polyhydroxyalkanoate Biomass - The patent application relates to a method of producing a monomer component from a genetically modified polyhydroxyalkanoate (PHA) biomass, wherein the biomass is heated in the presence of a catalyst to release a monomer component from the PHA. | 12-13-2012 |
| 20130023018 | METHOD FOR PRODUCING ACYLOXYPYRANONE COMPOUND, METHOD FOR PRODUCING ALKYNE COMPOUND, AND METHOD FOR PRODUCING DIHYDROFURAN COMPOUND - An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R | 01-24-2013 |
| 20130252289 | Method of Producing Volatile Organic Compounds from Microorganisms - A method for producing at least one compound selected from the group consisting of 1,8-cineole, and 1-methyl-1,4-cyclohexadiene is also described. The method includes culturing a microorganism on or within a culturing media in a container under conditions sufficient for producing the at least one compound. | 09-26-2013 |
| 20130316408 | MARINE STREPTOMYCES, PYRANOSESQUITERPENE COMPOUND, AS WELL AS PREPARATION METHOD AND APPLICATIONS THEREOF - The invention discloses marine | 11-28-2013 |
| 20140051135 | PLANT CELL CULTURE FOR PRODUCTION OF NATURAL PRODUCTS WITH REDUCED GLUCOSINOLATE CONTAMINATION - Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described. | 02-20-2014 |
| 20140141475 | Separation Process - A process for treating a mixture of R,R- and S,S-lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme in the presence of a ketone solvent to produce a mixture comprising aliphatic ester of lactic acid corresponding to one lactide enantiomer, and the aliphatic ester of lactyllactic acid corresponding to the other lactide enantiomer. Also provided are processes for the production of S-lactic acid, S,S-lactide, poly-S-lactic acid, R-lactic acid, R,R-lactide, poly-R-lactic acid and stereocomplex polylactic acid. | 05-22-2014 |
| 20140141476 | GENES AND PROTEINS FOR ALKANOYL-COA SYNTHESIS - Polypeptides having alkanoyl-CoA activity have been identified and characterized, as have nucleic acids encoding these polypeptides. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds. | 05-22-2014 |
| 20140315264 | ENZYME ASSOCIATED WITH EQUOL SYNTHESIS - An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. | 10-23-2014 |
| 20140329286 | EQUOL CONCENTRATION INCREASING AGENT CONTAINING PSICOSE AS ACTIVE INGREDIENT - The present invention relates to a processed food composition containing, as an active ingredient, psicose, which is a saccharide having the function of stimulating a daidzein conversion into equol by an intestinal microorganism in the human body. | 11-06-2014 |
| 20140363858 | METHODS FOR HYDROXYLATING PHENYLPROPANOIDS - Provided herein are methods for producing an ortho-hydroxylated phenylpropanoid. In one embodiment the method includes culturing a microbe that includes HpaBC activity in the presence of a phenylpropanoid substrate. Also provided are genetically engineered microbes engineered to have greater levels of HpaB and/or HpaC than a control microbe. | 12-11-2014 |
| 20140370557 | GENETICALLY ENGINEERED MICROBES AND METHODS FOR PRODUCING 4-HYDROXYCOUMARIN - Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for the synthesis of other compounds. | 12-18-2014 |
| 20150010964 | METHOD FOR INCREASING YIELD OF TOTAL FLAVONOIDS IN GANODERMA LUCIDUM MYCELIUM - A method for increasing the yield of total flavonoids in | 01-08-2015 |
| 20150037851 | VARIANT LOVD POLYPEPTIDES AND THEIR USES - The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound | 02-05-2015 |
| 20150087033 | METHODS FOR MAKING TOCOFLEXOLS AND ANALOGUES THEREOF - Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material. | 03-26-2015 |
| 20150307908 | Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Bicyclic Compound And Uses Thereof - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a bicyclic compound. The present invention also relates to methods of using the compositions. | 10-29-2015 |
| 20150315621 | ONE-POT FERMENTATION PROCESS FOR SIMVASTATIN PRODUCTION - Simvastatin is a drug used in treatment of hypercholesterolemia because of its inhibitory activities towards cholesterol biosynthesis. The technology described herein is a novel method of biosynthesizing Simvastatin directly from an engineered microbial host (such as | 11-05-2015 |
| 20150361469 | CHEMICAL ENGINEERING PROCESSES AND APPARATUS FOR THE SYNTHESIS OF COMPOUNDS - The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. | 12-17-2015 |
| 20160010126 | PRODUCTION OF CANNABINOIDS IN YEAST | 01-14-2016 |
| 20170233780 | METHOD FOR BIOCATALYTICALLY CYCLIZING GERANYLLINALOOL AND CYCLIZATION PRODUCTS THEREBY OBTAINED | 08-17-2017 |
