Entries |
Document | Title | Date |
20080199904 | Apparatus and method for detecting and identifying microorganisms - The present invention is an apparatus for detecting the presence, quantity and identity of one or more microorganisms in a sample and a method for using the same. The apparatus is composed of one or more chambers and a sensing element for sensing microorganisms. In particular embodiments, the sensing element is an array of chemoresponsive dyes deposited on a substrate in a predetermined pattern combination, wherein the combination of the dyes have a distinct and direct spectroscopic, transmission, or reflectance response to distinct analytes produced by the microorganism which is indicative of the presence, quantity and identity of the microorganism. | 08-21-2008 |
20080220466 | In Vitro Techniques For Use With Stem Cells - A method is provided for use with extracted blood, including (a) applying blood to a first gradient suitable for selecting first-pass cells having a density less than 1.077 g/ml; (b) applying the first-pass cells to a second gradient suitable for selecting second-pass cells having a density between 1.055 and 1.074 g/ml; (c) increasing the number of cells having a density between 1.055 and 1.074 g/ml, by culturing the second-pass cells for a period lasting between 3 and 30 days; and (d) identifying endothelial progenitor cells in the cultured cells. Other embodiments are also described. | 09-11-2008 |
20080220467 | Filter Snapper - A device for applying an axial compressive force to a fluid contamination detection system comprising a cup joined by a frangible connection to a filter ring, the force being sufficient to break the frangible connection and collapse a portion of the ring into the cup without damaging the ring. The device includes a stop element and a platform and an actuating mechanism for reciprocally moving the platform relative to the stop element. In a first position, the distance between the platform and the stop element is greater than the axial length of the detection system when the cup and the filter ring of the funnel are connected to each other, and in a second position, the distance between the platform and the stop element is less than the axial length of the detection system when the cup and the filter ring of the funnel are connected to each other. | 09-11-2008 |
20080227142 | Invasive chemometry - The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest. | 09-18-2008 |
20080248518 | E.coli and salmonella test kit - A method for testing for the presence of bacteria in the field includes using a mixer and frother or a reagent to disrupt bacteria cells. A sample is collected from a source suspected to be contaminated by bacteria. A mixer and frother or similar mixer is used to mix the sample, or a reagent is added to the sample, to form an elute by disrupting bacteria cells present in the sample to expose bacteria enzymes. A reagent pad is immersed in the elute and then withdrawn from the elute, or a drop of the elute is deposited on a reagent pad. After a waiting period, the reagent pad is observed to determine if the bacteria is present in or on the source. The source may be a body of water, produce, prepared food, a food preparation area, or food processing equipment. The reagent is generally a lysis reagent. | 10-09-2008 |
20080254502 | Method and Apparatus for Detection of Bioaerosols - A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol. | 10-16-2008 |
20080261264 | Culture Medium for Detecting of Clostridium Perfringens - The invention relates to a culture medium for the detection of | 10-23-2008 |
20080268493 | Identification Method Based On Surface-Enhanced Raman Scattering - This invention is related to a reproducible identification method based on surface-enhanced Raman scattering (SERS), in which bacterial samples are used in identification of bacteria by mixing with the concentrated silver and gold nanoparticles. | 10-30-2008 |
20080286830 | Analysing Breath Samples for Volatile Organic Compound - The invention describes the use of a biomarker pentylfuran to detect bacterial and/or fungal pathogens. Pentylfuran is released from certain pathogens and detected in the headspace gas of an in vitro culture or in the breath sample of a patient. Pentylfuran is particularly useful in the detection of | 11-20-2008 |
20080286831 | SAMPLE COLLECTOR AND TESTER - Provided are devices and methods for testing solid, semi-solid, or liquid animal or environmental specimens. The multi-part device comprises a breakable seal that separates a specimen treatment chamber from a testing chamber. | 11-20-2008 |
20080293094 | Novel Enzymatic Substrates Derived from Phenoxazinone and Their Use as Developer in Detection of Microorganisms with Peptidase Activity - The invention concerns novel enzymatic substrates of the general formula below: | 11-27-2008 |
20080293095 | Polydiacetylene-Containing Solid Colorimetric and/or Fluorescent Detector, Method for Its Preparation and Uses Thereof - A colorimetric and/or fluorescent detector, which comprises a film of polydiacetylenes and lipids deposited on a substrate, wherein said film is coated with one or more layers, wherein at least one of said layers is capable of supporting the growth of microorganisms. Also provided are processes for preparing the novel colorimetric and/or fluorescent detector and uses thereof in the detection of bacteria. | 11-27-2008 |
20080299604 | METHODS AND TOOLS FOR DETECTING COLLAGEN DEGRADATION - Fluorophore-labeled collagen covalently bound to a cell culture vessel can be used to assay collagen degradation by a variety of cell types, including osteoclasts and tumor cells. Such assays provide a high throughput platform for rapid screening of large numbers of potential modulators of, for example, tumor metastasis or osteoclast differentiation and/or function. | 12-04-2008 |
20080305514 | METHOD FOR DETECTING MICROBES - The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for nucleic acid stain to form a second scan, and comparing said first scan and said second scan. | 12-11-2008 |
20080311615 | METHOD FOR CHIRAL SEPARATION OF LACTIC ACID ENANTIOMERS - A method for the separation and simultaneous determination of urinary D- and L-lactic acid enantiomers by high performance liquid chromatography tandem mass spectrometry (HPLC/MS/MS). The chiral separation was done using a chirobiotic teicoplanin aglycone column varying mobile phase parameters such as the acetic acid/triethylamine content and the aqueous/organic ratio. | 12-18-2008 |
20080311616 | Hydrophilic IR Transparent Membrane, Spectroscopic Sample Holder Comprising Same and Method of Using Same - The present invention features hydrophilic IR-transparent porous membranes, particularly hydrophilic IR-transparent porous polyethylene membranes and methods of preparing the hydrophilic membranes by treatment of hydrophobic IR-transparent porous membranes with plasma. The present invention further features spectroscopic sample holders which incorporate the hydrophilic IR-transparent porous membranes and methods of identifying bacteria and other microorganisms in samples by infrared spectroscopy. | 12-18-2008 |
20090004690 | COMPOSITION AND METHODS FOR MAKING 5, 10, 15, 20-TETRAKIS (CARBOXYPHENYL) PORPHINE - Presented is a method to detect precancerous states in mammalian cell and tissue samples comprising incubating a sample with solubilized 5, 10, 15, 20-tetrakis (carboxyphenyl)porphine (TCPP), measuring TCPP fluorescence in the sample, and categorizing the sample as non-cancerous, precancerous or cancerous based on TCPP fluorescence, as correlated with the respective states of the cells. In conjunction with the method a detection, a novel and more efficient method of solubilizing TCPP is presented, as well as a composition comprising TCPP solubilized by this method. | 01-01-2009 |
20090017490 | DNA Fragment Method for Producing Transformant for Protein Production and Utilization Thereof - An expression vector is constructed by transferring recombinant tomato mosaic virus (ToMV) cDNA, in which a coat protein gene of ToMV having a suppressor against a virus resistant reaction has been substituted by a GFP gene, into the downstream of a promoter capable of inducing steroid hormone-dependent transcription. In a transformed tobacco BY-2 cell obtained by transferring the above expression vector into a tobacco BY-2 cells, steroid hormone-dependent transcription is induced, thereby enabling the amplification of mRNA of the GFP gene and induction of the expression of GFP. | 01-15-2009 |
20090023179 | Reagent, Medium, and Method for Detection of Alicyclobacilus Acidoterrestris - To supply the reagent, medium, and method for detection of | 01-22-2009 |
20090023180 | Reduction of Shading in Microalgae - Methods provided herein are directed to increasing the efficiency of light utilization of photosynthetic microorganisms. Also provided are screening assays, genetic constructs, and photosynthetic microorganisms for increasing light utilization efficiency and production of molecules such as ATP, oxygen, hydrogen, and recombinant proteins. Methods provided herein can be performed with any photosynthetic microorganism, including prokaryotic and eukaryotic microorganisms. | 01-22-2009 |
20090029408 | Methods for Characterizing Cell Proximity - One aspect of the invention relates to a method of identifying cell adjacency in a coculture of cells. The method includes generating a first set of image data of the coculture of cells, the first set of image data comprising nuclear position data for each imaged cell; generating a second set of image data of at least a subset of the coculture of cells, the second set of image data comprising cell identifier data associated with a first cell type; generating a third set of image data of at least a subset of the coculture of cells, the third set of image data comprising cell identifier data associated with a second cell type; and identifying a group of cells in response to the nuclear position data, wherein each cell having the first cell type in the group is adjacent another cell in the group having the second cell type. | 01-29-2009 |
20090042241 | MICROFLUIDIC DEVICE - Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples. | 02-12-2009 |
20090081721 | HIGH-THROUGHPUT CELL ASSAYS - This invention provides high-through put methods and systems to identify and/or classify cells present in a sample. In one aspect, the method identifies the cell by determining the amount of thermal energy required to disrupt cell membranes. In another aspect, a method is for determining if an agent such as a drug will inhibit the growth of a cell by monitoring the amount of energy required to maintain a substantially constant temperature in a sample containing the cell grown in the presence of an agent or drug is provided. | 03-26-2009 |
20090104652 | METHOD AND APPARATUS FOR VIABLE AND NONVIABLE PROKARYOTIC AND EUKARYOTIC CELL QUANTITATION - A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as: a) quantitating bacteria in milk, yogurt, cheese, meat and other foods, b) quantitating yeast cells in brewing, fermentation and bread making, c) quantitating mammalian cells in research, food and clinical settings. The method is especially useful when both total and viable cell counts are required such as in the brewing industry. The method can also be employed to determine the metabolic activity of cells in a sample. The apparatus, device, and/or system used for cell quantitation is also disclosed. | 04-23-2009 |
20090117609 | USE OF TETRACYSTEINE TAGS IN FLUORESCENCE-ACTIVATED CELL SORTING ANALYSIS OF PROKARYOTIC CELLS PRODUCING PEPTIDES OR PROTEINS - A process of in vivo labeling and identifying recombinantly produced peptides or proteins within an unpermeabilized prokaryotic host cell. Recombinant prokaryotic cells expressing a fusion peptide comprising at least one tetracysteine tag were labeled in vivo using a biarsenical labeling reagent. A fluorescent activated cell sorter was used to identify and select subpopulations of fluorescent cells wherein the amount of fusion peptide in the cell was proportional to the amount of fluorescence detected. | 05-07-2009 |
20090123962 | Chemical Sensing Device - The present application relates to a chemical sensing device for detecting an analyte in a liquid sample containing suspended particles. The device comprises a radiation source adapted to generate electromagnetic radiation, a transducer ( | 05-14-2009 |
20090155839 | METHOD FOR DETECTING BACTERIAL SPORES - A method of detecting the presence and quantity of bacterial spores, which includes adding an electrophilic alcohol and an acid anhydride to a sample, admixing the sample with a solvent, and analyzing the sample. The sample may be analyzed by injecting the mixture into a gas chromatograph equipped with a mass spectra detector. | 06-18-2009 |
20090162891 | Effective Monitoring System or Anthrax, Smallpox, or Other Pathogens - A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and | 06-25-2009 |
20090170151 | FLOW-THROUGH CELL AND METHOD OF USE - There is disclosed a flow-through cell comprising a substrate defining a channel, having an inlet and an outlet, at least a portion of the substrate being light-permeable to allow particles within at least a portion of the channel between the inlet and the outlet to be optically detected through the substrate, wherein the flow-through cell comprises liquid-permeable particle retaining means located downstream of the at least a portion of the channel where particles can be optically detected, for allowing the flow of a liquid sample through the channel from the inlet to the outlet while retaining particles from the liquid sample whose dimensions exceed threshold dimensions within the channel, where they can be optically detected. The flow-through cell is particularly applicable to the detection of micro-organisms in drinking water. | 07-02-2009 |
20090176268 | Solid Nutrient Media Useful For Isolating And Identifying Alkaliphilic Bacteria - The present invention relates to a solid nutrient media composition having alkaline pH, useful for isolating and identifying alkaliphilic microorganisms in pure form. Te media composition consists of 5-15 g of carbon source, 2.5-10 g of peptone, 2.5-10 g of yeast extract, 0.5-1.5 g of dipotassium hydrogen phosphate; 0.1-0.5 g of magnesium sulphate heptahydrate, 30 μl-4 ml of super saturated solution of sodium hydroxide, 5-20 g of potassium chloride and 10-30 g of κ-carrageenan in one litre of distilled water. The potassium salt in combination with κ-carrageenan in specific proportion has been found to be a suitable replacement of agar in solidifying bacteriological media especially, for isolation of extreme alkaliphiles. The present invention also provides a method of using the solid nutrient media composition having alkaline pH to study biodiversity of cultivable alkaliphilic bacteria. | 07-09-2009 |
20090191585 | CELL IMAGE PROCESSING APPARATUS, CELL IMAGE DISPLAYING SYSTEM AND CELL IMAGE DISPLAYING METHOD - A cell image processing apparatus includes a large area image obtainer for obtaining a large area image which is obtained by imaging an area including a white blood cell and a red blood cell, a processing part for obtaining a portion image including the white blood cell from the large area image, and a memory for storing the portion image as an image for monitoring white blood cell and storing the large area image as an image for monitoring red blood cell. | 07-30-2009 |
20090197298 | METHOD FOR DETECTING MICROORGANISMS IN A BIOLOGICAL SAMPLE - This invention relates to a method for detecting at least one specific microorganism in a biological sample, said method comprising the following steps: a) culturing said biological sample in a culture medium, b) subjecting said culture medium to at least two radiations each presenting a specific wavelength, c) obtaining at least two different images of said culture medium using at least two reading systems, d) combining said at least two different images to produce at least one combined artificial image, and e) analyzing said combined artificial image to detect the presence of said at least one specific microorganism in the biological sample. The invention also relates to a device for application of the detection method according to this invention. | 08-06-2009 |
20090203065 | CELL CULTURE ARTICLE AND SCREENING - A method for producing a cell culture article having a synthetic polymer layer for incubating with cells includes diluting one or more (meth)acrylate monomers in a solvent and dispersing the diluted monomers on a surface of the cell culture article. Some or substantially all of the solvent is removed and the monomers are then polymerized on the surface of the article to form the synthetic polymer layer attached to the surface of the article. | 08-13-2009 |
20090215110 | WATER MONITORING SYSTEMS - The invention relates to a continuous water monitoring system, including components thereof, and a method relating thereto for continuously monitoring, in real-time, a water supply in order to detect contaminants therein. The system employs the use of a live culture of bioluminescent bacteria and suitable light detecting means. | 08-27-2009 |
20090233328 | METHOD FOR READING IMAGES, IN PARTICULAR FOR STUDYING THE DEVELOPMENT OF BIOFILM IN A CULTURE MEDIUM - A method for reading images of a base of a plate provided with at least one well containing a culture medium of micro-organisms includes: i) forming a opaquing layer covering a surface of the culture medium to form a reading base; and ii) imaging, at specific time intervals, the base of the well. using an imaging optical device. | 09-17-2009 |
20090239256 | Detection of Micro-Organisms - The present invention relates to a method of detecting the presence of a viable micro-organism of interest in a sample containing a contaminating micro-organism. | 09-24-2009 |
20090239257 | METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING - A method for analyzing a blood sample is provided that includes the steps of: a) providing a blood sample having one or more first constituents and one or more second constituents, which second constituents are different from the first constituents; b) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; c) admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce upon exposure to predetermined first wavelengths of light, and which colorant is operative to absorb light at one or more predetermined second wavelengths of light; d) illuminating at least a portion of the sample containing the first constituents and the second constituents at the first wavelengths and at the second wavelengths; e) imaging the at least a portion of the sample, including producing image signals indicative of fluorescent emissions from the first constituents and the second constituents and the optical density of the first constituents and the second constituents; f) determining a fluorescence value for each the first constituents and second constituents using the image signals; g) determining an optical density value for each of the first constituents and second constituents, which optical density is a function of the colorant absorbed by the constituents, using the image signals; and h) identifying the first constituents and the second constituents using the determined fluorescence and optical density values. | 09-24-2009 |
20090246822 | Composition for cell permeabilization comprising NOG, HMP, rubidium chloride and/or lithium chloride for detecting living cells on a membrane - The present invention relates to a composition for the permeabilization of the walls of microorganisms comprising the combination of octyl-β-D-glucopyranoside (NOG), sodium polyphosphates (HMP), and a salt chosen from lithium chloride or rubidium chloride, and a method for the enumeration and identification of cells on a membrane using said composition. | 10-01-2009 |
20090258385 | METHOD OF ANALYZING CELLS BY FLOW CYTOMETRY, USE OF AN ANTIOXIDANT AND/OR FREE RADICAL-SCAVENGING AGENT IN SUCH A METHOD AND INCUBATION BUFFER COMPRISING AN ANTIOXIDANT AND/OR FREE RADICAL-SCAVENGING AGENT - The invention relates to a method of analyzing cells by flow cytometry and the use of an antioxidant and/or free radical-scavenging agent in such a method. It also relates to an incubation buffer comprising an antioxidant and/or free radical-scavenging agent. The method of the invention comprises a step for labeling cells in a labeling solution comprising an incubation buffer and the labeling antibody or antibodies conjugated with at least one fluorochrome which is an APC tandem and an antioxidant and/or free radical-scavenging agent. The invention finds application in the field of the analysis of cells by flow cytometry, in particular. | 10-15-2009 |
20090275075 | METHODS AND SYSTEMS FOR ENSURING THE SECURITY OF FOOD COMMODITIES - Aspects include claims, systems, and methods for testing food commodities, including without limitation bulk food commodity stores to identify the presence of contaminants. Such contaminants tested for may include biological, chemical, or radio nuclear material. Another aspect is marking and/or tracking food commodity stores that have been certified as either being contaminated or safe. Still another aspect is an automated or automatic system for measuring the level of contamination in a given food commodity store, and for marking and tracking food commodity stores tested for contamination. | 11-05-2009 |
20090305336 | DEVICES AND METHODS FOR SAMPLING MICROBIAL FLORA - Methods, devices and kits for sampling for a microorganism or microbial population on the digits of the extremities of an individual are described. In embodiments of the invention, the device comprises a container, such as a cell culture plate, with a growth medium that is delineated into multiple quadrants, which can be visualized through the growth medium, to aid in the placement of a digit within a designated location on the growth medium. | 12-10-2009 |
20090311740 | COLORIMETRIC METHOD AND RELATIVE DEVICE FOR BACTERIAL LOAD DETECTION - A method for detecting a bacterial load comprising adding a sample for analysis to an analysis reagent in a sterilized reaction container, thermostatting the reaction container at a temperature of between 25 and 45° C., and verifying the change in colouring of the analysis reagent. The analysis reagent is an aqueous solution comprising amino acids chosen from the group consisting of meat peptones, vegetable peptones, casein hydrolysates, tryptose, tryptones and yeast extract; glucides chosen from monometric or oligomeric glucides metabolisable by micro-organisms; a buffer system suitable for maintaining the pH between 5.5 and 8.5; a redox indicator with potential between −250 and +250 mV and/or a pH indicator with colour change interval between pH 4.0 and pH 9.0; and a water-immiscible organic liquid compound having a lower density than water and suitable for separating the aqueous phase from a gaseous phase existing prior to the analysis or formed during the reaction. | 12-17-2009 |
20090311741 | ENVIRONMENTAL EVALUATION INSTALLATION AND ENVIRONMENTAL EVALUATION METHOD - An environmental evaluation installation including an evaluation chamber | 12-17-2009 |
20090317859 | CALORIMETRIC ASSESSMENT OF MICROORGANISMS AND USE THEREOF - Methods, integrated kits and systems for the rapid detection, identification and/or quantification of microorganisms in samples such as blood samples via calorimetry are disclosed. | 12-24-2009 |
20090317860 | STANDARD MATERIAL FOR A PARTICLE ANALYZER - A standard material that is used for judging an abnormal portion in a particle analyzer is described. The standard material comprises first standard particles to be fluorescence-stained by a fluorescence-staining treatment and second standard particles that have preliminarily contained a fluorescence dye. A method and an analyzer that can judge an abnormal portion in a particle analyzer by using such a standard material are also described. | 12-24-2009 |
20090325221 | Temporary Tattoo Decals for Detecting the Presence of an Analyte - Temporary tattoos to be applied to the skin of a wearer for the detection of an analyte are generally disclosed. The temporary tattoo can be applied to the skin via a temporary tattoo decal. The temporary tattoo can indicate the presence of an analyte by displaying a certain spectral response (e.g., color change) in the presence of a targeted analyte. This change in color can indicate to the wearer and/or caregiver the presence of the targeted analyte in real-time. | 12-31-2009 |
20100021959 | High Throughput Screening Method for Assessing Heterogeneity of Microorganisms - The invention relates to the field of microbiology. Provided is a method which is particularly powerful for High Throughput Screening (HTS) purposes. More specific a high throughput method for determining heterogeneity or interactions of microorganisms is provided. | 01-28-2010 |
20100021960 | Methods and compositions for pathogen detection using fluorescent polymer sensors - Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification. | 01-28-2010 |
20100028938 | METHOD OF SCREEING FOR PATHOGENS - Disclosed is a method of screening for the presence of MRSA in a subject, the method comprising the steps of:
| 02-04-2010 |
20100047851 | Methods and compositions for the detection of microbial contaminants - The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay. | 02-25-2010 |
20100047852 | SELECTIVE CULTURE MEDIUM - The present invention discloses a selective culture medium for detecting MRSA and selective drug or multidrug resistant microorganisms where the expression of said (multi)drug resistance is by virtue of the production by said microorganisms of β-lactamase enzymes. The medium comprises: (i) a broad spectrum antibiotic capable of selectively inhibiting growth/replication of (a) organisms that do not produce β-lactamase enzymes, (b) organisms that while producing β-lactamase do not exhibit an ESBL or AmpC phenotype and (c) Methicillin-susceptible | 02-25-2010 |
20100047853 | Ex Vivo Culture, Proliferation and Expansion of Intestinal Epithelium - Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo. | 02-25-2010 |
20100068754 | Density-based cell detection system - The invention provides a low-cost method for identifying and/or measuring a subpopulation of cells in a biological sample, such as a subpopulation of CD4-positive cells in a whole blood sample. In accordance with the invention, one or more cell surface markers are identified on a subpopulation of interest, which collectively are present in higher numbers on the cells of the subpopulation than on cells not in the subpopulation of interest. A probe comprising a binding compound and a density label are combined with the sample and the resulting mixture is centrifuged or sedimented through a density medium in a capillary. Labeled cells of interest pass through the density medium and stack at the bottom of the capillary where they may be visually detected and quantified by the height of the stack. | 03-18-2010 |
20100068755 | Method and system for detection and/or characterization of a biological particle in a sample - The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle, that may be present in the sample. | 03-18-2010 |
20100068756 | METHOD AND APPARATUS FOR DETECTING AND QUANTIFYING BACTERIAL SPORES ON A SURFACE - A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: bacterial spores are transferred from a place of origin to a test surface, the test surface comprises lanthanide ions. Aromatic molecules are released from the bacterial spores; a complex of the lanthanide ions and aromatic molecules is formed on the test surface, the complex is excited to generate a characteristic luminescence on the test surface; the luminescence on the test surface is detected and quantified. | 03-18-2010 |
20100075368 | Media for recovery of microorganism in the presence of antibiotics - The present invention provides a media and a method of using such as media for the bioburden or sterility testing of antibiotics or environmental testing of antibiotic manufacturing areas. The medium contains one or more divalent or trivalent cation constituents, preferably of magnesium, calcium, aluminum and iron that allow for microorganism growth even in the presence of residual antibiotic. | 03-25-2010 |
20100081166 | Microbial Detection Assembly - A microbial detection assembly is disClosed which includes a tubular body, a pierceable septum, and a plunger. The tubular body defines a longitudinal axis and has a first end and a second end. The pierceable septum is configured to seal the first end of the tubular body. The plunger head is configured to substantially close the second end of the tubular body. Together, the plunger head, the pierceable septum, and the tubular body define a reservoir dimensioned to receive a medium and a sample substance. Additionally, the plunger head is positioned and is movable within the tubular body in response to changes in pressure within the reservoir. | 04-01-2010 |
20100093019 | SAMPLE HANDLING DEVICE - A device for use in handling a sample, the device including a number of deformable cavities provided on a surface of a substrate, at least one of the cavities being a sample cavity for receiving a sample and a number of fluid channels connecting the cavities such that in use, selective deformation of the cavities causes the sample to be selectively combined with one or more substances. | 04-15-2010 |
20100093020 | SOLVENT TOLERANT MICROORGANISMS AND METHODS OF ISOLATION - bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant | 04-15-2010 |
20100120084 | REACTION MEDIUM FOR IDENTIFYING/DETECTING MICROORGANISMS - The present invention relates to a reaction medium for identifying/detecting microorganisms, that comprises at least one active molecule encapsulated in a cyclodextrin. | 05-13-2010 |
20100120085 | Method for separation, characterization and/or identification of microorganisms using mass spectrometry - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for interrogation of the separated microorganism sample by mass spectrometry to produce a mass spectrum of the microorganism and characterizing and/or identifying the microorganism in the sample using the mass spectrum obtained. | 05-13-2010 |
20100124763 | Method for detection, characterization and/or identification of microorganisms in a sealed container - The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample. The method may be accomplished in a sealed container by utilizing a first step time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle that may be present in the sample. The method further provides for a subsequent step for the separation, characterizion and/or identification of the microorganisms in the sealed container. | 05-20-2010 |
20100129857 | Methods for the isolation and identification of microorganisms - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides methods for separating, characterizing and/or identifying microorganisms in situ within a single system. | 05-27-2010 |
20100129858 | Method for separation, characterization and/or identification of microorganisms using spectroscopy - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements. | 05-27-2010 |
20100136607 | SENSOR DEVICE - The invention relates to a sensor device for detecting CO | 06-03-2010 |
20100136608 | Multiple Filter Array Assay - The present invention relates to a method and device for the assay and determination of the concentration of organisms or other filterable constituents of a fluid test sample. The method includes the steps of exposing, processing, and analyzing a liquefied sample in a filter tray apparatus. Each filter element (FE) filters a volume of liquid from a common fluid test sample. Excess unfiltered liquid and filtrate is removed from the filter tray apparatus. Each filter element contained in the filter tray apparatus is exposed to culture medium and/or appropriate testing reagents introduced to the apparatus to generate an indicator of the filterable constituent. Final examination is conducted on the filter tray apparatus for the indication of the presence and/or absence of filtered constituents in the multiple filter elements. The presence/absence information defines the concentration of the filterable constituent in the fluid test sample. | 06-03-2010 |
20100136609 | Method for separation, characterization and/or identification of microorganisms using raman spectroscopy - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for Raman spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said Raman spectroscopic measurements. | 06-03-2010 |
20100136610 | Methods And Microfluidic Devices For Single Cell Detection Of Escherichia Coli - The present invention features a microfluidic device for detecting | 06-03-2010 |
20100143964 | COMPOSITIONS AND METHODS FOR CONCENTRATING AND DEPLETING MICROORGANISMS - Methods for concentrating microorganisms in a liquid sample or depleting microorganisms therefrom, utilizing polymeric compounds having affinity to microbial cells that are composed of a plurality of positively charged amino acid residues and two or more hydrophobic moieties are disclosed. Also disclosed are devices for concentrating and methods for detection and identification microorganisms in a liquid sample. | 06-10-2010 |
20100159504 | Integrated Microbial Collector - A system for real-time sizing of fluid-borne particles is disclosed. The system further determines, in real time, whether the detected particles are biological or non-biological. As the fluid is being tested, it is exposed to a microbe collection filter which is cultured to determine the type of microbes present in the fluid being tested. | 06-24-2010 |
20100159505 | REAL-TIME MONITORING OF AGE PIGMENTS AND FACTORS RELATING TO TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES AND APPARATUS - A fluorescent spectroscopic method and apparatus for real time direct detection of transmissible spongiform encephalopathies in central nervous system tissue by monitoring the fluorescence of intrinsic markers in the tissue by illuminating the tissue with UV or visible light having an appropriate wavelength, and the resulting emission spectra is detected and examined in the region from 350 to 650 nm. A higher intensity in this region is indicative of infected tissue. The apparatus and method would not interfere with existing slaughterhouse line speeds or procedures, and could be used on live animals. | 06-24-2010 |
20100184123 | Gas Exchange Detection Method and Device - The invention relates to a gas exchange detection method and device particularly, but not exclusively, for rapid detection of the presence of micro-organisms, the effect of an additional substance upon a micro-organism and/or the rate at which oxygen is consumed, in solutions, aqueous emulsions and/or suspensions. | 07-22-2010 |
20100216183 | MICROBIAL DETECTION APPARATUS, MICROBIAL DETECTION METHOD, AND SAMPLE CONTAINER USED THEREIN - The sample container has a two-layer membrane filter comprising a first layer as an upper layer serving as a hydrophilic membrane filter and a hydrophobic membrane filter as an underlying second layer capable of filtering an aqueous solution without the use of a wetting agent and by means of a formed negative pressure. Using this sample container, a large amount of an aqueous sample solution is filtered by means of a negative pressure formed by a suction portion to capture microbes in the aqueous sample solution by the hydrophilic membrane filter. Then, the negative pressure is restored to normal pressure, and a microbial dissolution solution is then added to the membrane filter to retain the microbial dissolution solution for a given time on the hydrophobic membrane filter. Then, the microbial dissolution solution is dispensed to a reaction container containing a luminescent reagent, and luminescence is detected to detect the microbes. | 08-26-2010 |
20100221771 | Serum-Free Growth Medium for Acholeplasma laidlawii and Methods for Retention Testing Sterilizing Grade Filters - A method for retention testing sterilizing grade filters comprises: a) providing a stock of | 09-02-2010 |
20100227359 | System and method for detection of substances - A system, a method, and apparatus for determining the presence of an agent in a sample. The system includes a sampler for collecting the sample, and an attachment means for attaching the sampler to the sample. In addition, the system includes a carrier, wherein the sampler with the sample is substantially aligned with a portion of the carrier. The system also includes an analyzing device which is substantially aligned with the carrier and the sample. Finally, the system includes a chemistry for identifying an indicator of the agent in the sample as determined by the analyzing device. | 09-09-2010 |
20100227360 | SALMONELLA SELECTIVE ENRICHMENT MEDIUM CONTAINING TETRATHIONATE AND MAGNESIUM SALT - The invention relates to a salmonella selective enrichment medium containing tetrathionate or a salt thereof and at least one type of magnesium salt and to a method for detecting salmonella in a sample by using said selective enrichment medium. | 09-09-2010 |
20100233756 | Animal Feed Kibble with Protein-Based Core and Related Methods - Kibble-type animal feeds and pet foods including a vegetable protein-based core matrix and a coating of a fat and at least one additive are described. The coating may include a probiotic enriched coating. Methods of forming the kibble-type animal feeds and pet foods are also described. Probiotic coating for a kibble showing acceptable stability and bioactivity are disclosed and methods for assessing the bioactivity of a probiotic in a food composition are also described. | 09-16-2010 |
20100240091 | BIOCHEMICAL TEST FOR CONFIRMING THE PRESENCE OF L. MONOCYTOGENES - The invention relates to a biochemical test for confirming the presence of | 09-23-2010 |
20100240092 | DETECTION METHOD AND DETECTION APPARATUS - Provided is a method of adjusting detection sensitivity in detecting a sample in a channel. A detection method of optically detecting a sample includes: forming a multilayer flow, in which at least one of layers of the multilayer flow contains the sample; introducing light into at least one of layers of the multilayer flow; and detecting a signal generated from the multilayer flow in response to the introduced light, to detect the sample. The sample includes one of a chemical substance, a molecule, a cell, a particle, and a mixture thereof. At least one of fluids included in the multilayer flow has a refractive index different from a refractive index of another one of the fluids. | 09-23-2010 |
20100248297 | PARTICLES AND MANUFACTURING METHODS THEREOF - Particles and manufacturing methods thereof are provided. The manufacturing method of the particle includes providing a precursor solution containing a precursor dissolved in a solution, and irradiating the precursor solution with a high energy and high flux radiation beam to convert the precursor to nano-particles. Particles with desired dispersion, shape, and size are manufactured without adding a stabilizer or surfactant to the precursor solution. | 09-30-2010 |
20100248298 | MASS SPECTROMETRIC IDENTIFICATION OF MICROORGANISMS IN COMPLEX SAMPLES - Microorganisms are identified as present in a complex sample or mixed culture by acquiring a mass spectrum of the sample and comparing it to combination spectra, each of which is formed by combining at least two reference mass spectra of known microorganisms. Microorganisms corresponding to the reference spectra used to form the combination spectrum are identified as present in the sample if that combination spectrum exhibits a better match with the sample mass spectrum than any one of reference mass spectra used to form that combination spectrum. It is also possible to identify microorganisms by forming a difference spectrum by subtracting a reference mass spectrum from the sample mass spectrum and comparing the difference spectrum to the reference mass spectra. | 09-30-2010 |
20100248299 | Microbial Detection and Quantification - Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. | 09-30-2010 |
20100255529 | DEVICE AND METHOD FOR MICROBIOLOGICAL ANALYSIS OF BIOLOGICAL SAMPLES - The device for microbiological analyses on samples of body fluids comprising: an incubation area for containers containing said samples; an analyzer for analyzing the inner atmosphere of said containers; a sorting system to sort the containers according to the carbon dioxide content detected by said analyzer. | 10-07-2010 |
20100273207 | Methods for Diagnosis of Sepsis and Risk of Death - The present invention is directed to methods for diagnosis of sepsis and high risk of sepsis death. Such methods are directed to subjects presenting to healthcare facilities with symptoms for sepsis. Clinico-metabolomic classifiers are tested and compared in the methods of the present invention. | 10-28-2010 |
20100273208 | MICROORGANISM TESTING APPARATUS - To eliminate the necessity of a dedicated optical system and the flowing of fluorescent microparticles for aligning excitation light with a flat plate-shaped flow cell which internally includes a flow path, a microorganism testing apparatus includes: a first detector that detects fluorescence emitted from microorganisms flowing through a detection flow path when a microorganism detection unit included in a microorganism testing chip is irradiated with excitation light, and converts the fluorescence to an electrical signal; and a second detector that detects scattered light similarly emitted from the microorganisms flowing through the detection flow path, and converts the scattered light to an electrical signal. The alignment of the detection flow path is performed in the direction of the optical axis of the excitation light by controlling and moving a stage having the microorganism testing chip mounted thereon based on the intensity of fluorescence detected by the first detector. | 10-28-2010 |
20100279338 | CELL CARRIER CODING - There are provided cell carrier devices for use in cell observation systems, enabling determination of the location of the region under observation by virtue of coding information present in the field of view of the viewing device, even at high magnification. Other embodiments are also disclosed. | 11-04-2010 |
20100279339 | APPARATUS AND METHOD FOR DETECTING BACTERIAL GROWTH BENEATH A WOUND DRESSING - An apparatus and method are provided for visually monitoring, detecting, and/or determining the presence, absence, and/or growth of harmful or potentially harmful bacterial microorganisms beneath a wound dressing, in one example used to cover an indwelling central venous catheter or other catheter. A bacteria detection apparatus includes a barrier membrane, a permeable membrane for placement proximate a wound or a catheter insertion site, and an indicator between the barrier membrane and the permeable membrane for indicating the presence of bacteria proximate the permeable membrane. A method of using a bacterial growth detection apparatus is also provided. | 11-04-2010 |
20100285521 | ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE - Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module. | 11-11-2010 |
20100285522 | Versatile Multichannel Capillary Biosensor System - The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having at least two positions, with a first position being connected to a second bypass channel and a second position being connected to a detector for detecting the analyte. The device has a pump connected at one end to the second bypass channel and the detector and at a second end to a waste vessel. The device also has a control system for controlling the device. The analyte can be selected from the group of microorganisms, macromolecules, and small molecules. | 11-11-2010 |
20100291617 | RAPID DETECTION OF VOLATILE ORGANIC COMPOUNDS FOR IDENTIFICATION OF MYCOBACTERIUM TUBERCULOSIS IN A SAMPLE - In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence of the bacteria. | 11-18-2010 |
20100291618 | Methods for rapid identification and/or characterization of a microbial agent in a sample - A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically. | 11-18-2010 |
20100291619 | Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample - A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device. | 11-18-2010 |
20100297690 | Detection of salmonella lactose+ - The invention relates to a medium for the detection and/or identification of | 11-25-2010 |
20100297691 | DEVICES AND PROCESSES FOR COLLECTING AND CONCENTRATING SAMPLES FOR MICROBIOLOGICAL ANALYSIS - The present invention refers to manual devices for the collecting and concentrating liquid samples for microbiological analysis and their respective methods of use. The manual devices comprise a body which contains a sample, a removable support, a microporous membrane, and a plunger. The present invention is also directed to methods of collecting and concentrating of liquid samples onto a microporous membrane for micro-biological analysis. | 11-25-2010 |
20100304429 | METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK - Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. | 12-02-2010 |
20100311108 | System and method for agitation of multiple specimen containers - A system is disclosed for agitating multiple specimen containers each containing a sample and a growth medium. The system includes a plurality of racks. The racks have a plurality of receptacles, each of which is adapted for holding a specimen container. The racks include a first rack oriented in a first direction and a second rack oriented in a second direction different from the first direction. The system also includes a rotating turret having a frame holding the racks. The frame is rotatable about an axis, wherein the rotating turret operates to rotate the racks about the axis to an access position, e.g., where a user may access the specimen containers. The system also includes an agitation assembly coupled to the racks. The agitation assembly rocks the racks back and forth thereby agitating specimen containers held by the racks. In one configuration, the system is incorporated into an automated instrument detecting whether a microbiological agent is present in the specimen container. In another configuration, the system is incorporated into an automated instrument identifying or characterizing the microbiological agent. | 12-09-2010 |
20100317052 | PROCESS FOR DETECTING HELICOBACTER PYLORI USING ALIPHATIC AMIDES - The present invention provides a process for detecting | 12-16-2010 |
20100323391 | Method of Detecting Microorganisms with a Specimen - This invention concerns a process for preparing reagents intended for a microorganism detection test and notably an infection in humans or animals, wherein the following steps are included:
| 12-23-2010 |
20100323392 | Metering Technique for Lateral Flow Assay Devices - A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques. | 12-23-2010 |
20100330613 | METHODS FOR DETERMINING EFFICACY OF CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best treatment or agent for the particular patient. Specific method innovations such as tissue sample preparation techniques render this method practically as well as theoretically useful. By subjecting uniform samples of cells to a wide variety of active agents (and concentrations thereof), the most promising agent and concentration for treatment of a particular patient can be determined. | 12-30-2010 |
20110003328 | SYSTEM FOR DETECTING MICROBIAL CONTAMINATION - The present invention relates to a system for detecting microbial contamination of a liquid specimen comprising a device for concentrating micro-organisms from a liquid specimen, having (i) a hypobaric chamber, (ii) a filter housing comprising a liquid-permeable bed of an adsorbent material and adapted for being fluidly connected to said hypobaric chamber, and (iii) a vacuum pump adapted for being fluidly connected to said hypobaric chamber, said system further comprising a kit for detection of micro-organisms adsorbed to said adsorbent material, wherein said kit is based on enzymatic detection using chromogenic and/or fluorescent substrate analogues. | 01-06-2011 |
20110003329 | METHOD FOR NEUTRALIZATION OF ANTIBIOTICS IN A CULTURE MEDIUM - The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a culture media comprising one or more primary amine-containing compounds. | 01-06-2011 |
20110003330 | MICROFLUIDIC DEVICE - The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard data storage capabilities. In certain other embodiments, the microfluidic devices have onboard anticoagulants. In certain other embodiments, the microfluidic devices have onboard test and control channels. In certain other embodiments, the microfluidic devices have integrated collection media. In certain other embodiments, the microfluidic devices have multiple onboard test channels. In certain other embodiments, the microfluidic devices have localized temperature control. In certain other embodiments, the microfluidic devices have anatomy simulating regions. In certain other embodiments, the microfluidic devices have complete assay capabilities. In certain other embodiments, the microfluidic devices have dissociable sections. In certain other embodiments, the microfluidic devices have means for performing functional assays. | 01-06-2011 |
20110008824 | DEVICE AND METHOD OF BACTERIA DETECTION - A bacteria measurement device and method are provided, which separate bacteria from a target object and attach the bacteria to an antibody with fluorescein isothiocyanate applied thereto, generate light using a light emitting unit, and excite the fluorescein isothiocyanate, and in which the excited fluorescein isothiocyanate secondarily emits light, and a light receiving unit receives a light output signal generated through the secondary emission, converts the light output signal into an electrical signal, and converts an analog signal which is the electrical signal into a digital signal, thus measuring the amount and type of bacteria. | 01-13-2011 |
20110014645 | METHOD FOR DETERMINING A COMPLETE BLOOD COUNT ON A WHITE BLOOD CELL DIFFERENTIAL COUNT - Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device. | 01-20-2011 |
20110020859 | DEVICE COMPRISING A COLOURED AND BIODEGRADABLE POLYMER LAYER FOR ANALYZING THE AGE AND/OR QUALITY OF A NATURAL PRODUCT (INTEGRATED FRESHNESS INDICATOR) - The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their use. | 01-27-2011 |
20110020860 | FECAL EXAMINATION METHOD AND COLLECTION CONTAINER - A method for conducting a fecal examination includes providing a collection spoon and a collection container comprising a transparent body having a cap which can be removed to permit fecal matter to be received in the collection container with the spoon to be mixed with a flotation material to aid in separating the fecal matter and ova or eggs of parasites that may be contained in the fecal matter and then dispensed through a filter mounted in the cap of the collection container to a test tube and a cover slip on the test tube for examination of the filtered material for the presence of the ova of parasites. | 01-27-2011 |
20110027822 | SYSTEMIC LUPUS ERYTHEMATOSUS - This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment effectiveness are provided herein. | 02-03-2011 |
20110045525 | Method for Flagging a Sample - A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells. | 02-24-2011 |
20110045526 | SELECTION OF USEFUL FUNGAL STRAINS - The present invention provides methods for screening for a desired filamentous fungus that produces cellulase more efficiently and/or with increased specific activity. It also provides filamentous fungi that produce cellulase more efficiently. | 02-24-2011 |
20110053211 | PROCESS AND DEVICE FOR DETERMINING THE CONDITION OF BIOLOGICAL MATERIAL, IN PARTICULAR FOOD - The invention relates to a process for determining—remotely and without taking samples—the condition of biological material, in particular food, as well as a device for performing this process. Radiation emission is thus induced with coherent beams in the material to be examined and is directly measured, whereby the measured values are compared to a nominal or boundary value. To this end, the device has a radiation source for emitting coherent beams, a detector for determining the induced radiation emission, and a control device, whereby the control device contains a microcomputer unit for comparison of the determined radiation emission with the nominal and boundary values that are stored in the memory. | 03-03-2011 |
20110053212 | BLOOD ANALYZER, BLOOD ANALYSIS METHOD, HEMOLYTIC AGENT AND STAINING AGENT - This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion. | 03-03-2011 |
20110070605 | REVERSIBLE MHC MULTIMER STAINING FOR FUNCTIONAL PURIFICATION OF ANTIGEN-SPECIFIC T CELLS - The present invention relates to a new method for reversible staining and functional isolation or characterization of cells, e.g. antigen-specific T cells. With this technique, the original functional status of cells can be substantially maintained after their identification and purification. Thus, this new method is of broad benefit for basic research and clinical applications. | 03-24-2011 |
20110076714 | Method for the presence detection of microorganisms in a bioreactor, bioreactor and arrangement - The invention relates to a method for the presence detection of microorganisms in a bioreactor (B), to a bioreactor (B), and to an arrangement for performing the detection method. In order to reduce the staffing expense during the detection analysis of the presence of undesirable microorganisms in a bioreactor (B) after the bioreactor (B) has been cleaned, the detection method is carried out for microorganisms present in a bioreactor (B) such that a) a nutrient medium is selectively applied to defined areas of the bioreactor (B) in a controlled manner by a control unit (SE), b) an incubation having a defined time is performed in the bioreactor (B), c) after the incubation has been completed, the nutrient medium is removed from the defined areas in the bioreactor (B) and fed to an analysis unit (AE), in which the presence of microorganisms or decomposition products is determined, d) the analysis result determined in c) is then sent to the control unit (SE), which based on the results of the analysis selects a suitable process step from the predefined process steps for the further operation of the bioreactor (B). | 03-31-2011 |
20110076715 | METHOD OF SINGULATING EMBRYOS - A method of singulating embryos is provided. The method includes providing a plurality of embryos ( | 03-31-2011 |
20110076716 | BACTERIA ANALYSIS APPARATUS, BACTERIA ANALYSIS METHOD AND COMPUTER PROGRAM PRODUCT - A bacteria analysis apparatus comprising: a specimen preparation section for preparing a first measurement specimen from a sample by using a first enzyme; a detecting section for detecting bacteria included in the first measurement specimen; and an information processing section for outputting information for supporting determination of kind of bacteria included in the sample on the basis of the detection result of the first measurement specimen. A method and a computer program product is also disclosed. | 03-31-2011 |
20110081676 | RAPID DETECTION OF VIABLE BACTERIA SYSTEM AND METHOD - An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample. | 04-07-2011 |
20110086383 | APPARATUS AND METHODS FOR TREATING ALLOGRAFT PRODUCTS - Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts and methods for determining microbial contamination using the apparatus. | 04-14-2011 |
20110086384 | IDENTIFICATION OF BACTERIAL SPECIES AND SUBSPECIES USING LIPIDS - The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. | 04-14-2011 |
20110091931 | Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies - Described herein are methods and techniques for the determination of reactive oxygen species in resected animal and human tissues. Also described herein are methods for determining the efficacy of anti-oxidant, oxidative stress modulatory, or anti-inflammatory drug chemoprevention or chemotherapy for the prevention and/or therapy of chronically inflamed and/or progressive cancers and pathophysiologies. | 04-21-2011 |
20110091932 | Automated extraction and purification of samples using optical tweezers - An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping. | 04-21-2011 |
20110104743 | Dynamic Light Scattering for in vitro Testing of Bodily Fluids - A method of diagnosing a pathological condition by detecting microparticles in a sample of bodily fluid using dynamic light scattering (DLS) is disclosed. The detection of microparticles in the bodily fluid by DLS may be used as an indicator of existing disease, to evaluate a risk of disease, as well as to monitor the efficacy of a treatment for disease. | 05-05-2011 |
20110111451 | Gross Hematuria Evaluator and Methods for Making and Using Same - A device for evaluating the blood content in a plurality of media may include a display having a plurality of columns, each column having a plurality of color-block rows, where the colors are created by diluting blood in the respective medium to obtain a color, and then substantially matching that color with a row in the column. Additionally or alternatively, the columns may represent blood diluted in the same sample, but observed at different times. The display may include gaps between columns to accept a catheter in which the sample to be analyzed is placed and a legend identifying the medium and blood dilution for each column and row, as well as the time of aging, if any, for a column. | 05-12-2011 |
20110111452 | METHOD AND KIT FOR DIAGNOSIS OF MALE FERTILITY - A method and kit are disclosed for the diagnosis of male fertility. | 05-12-2011 |
20110117595 | Testing Unit and Method for Testing a Sterilization Packaging Unit - A testing unit and a method of testing a sterilization packaging unit for microbial contamination of sterilized objects after they have been sterilized are disclosed. The testing unit includes a dry matrix for accommodating a nutrient medium and a receptacle containing a liquid. By applying the liquid onto the matrix, the matrix is provided with a nutrient medium. In the method, the testing unit is inserted into the sterilization packaging unit which is sterilized and stored. At a desired point in time, the receptacle is opened in order to produce the nutrient medium in the matrix. After a possible multiplication of microbes on the matrix, an observation of microbes takes place. The invention also relates to a sterilization packaging unit which has a rigid outer casing and is suitable for the application of the method. | 05-19-2011 |
20110124038 | AUTOMATED TRANSFER MECHANISM FOR MICROBIAL DETECTION APPARATUS - The present invention is directed to a method and automated transfer means for transferring a container within an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system. | 05-26-2011 |
20110124039 | STAINING PROCESS AND APPARATUS USED IN BACTERIOLOGY - The present invention refers to a staining process used in bacteriology able to standardize and make Gram's staining procedure easier and faster, preventing variations in its process. | 05-26-2011 |
20110143391 | METHOD FOR TYPING AND IDENTIFICATION OF MICRO-ORGANISMS - The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples of said micro-organism, and/or between spectra of samples of different micro-organisms, are substantially eliminated as a source of signal variance in a dataset of said spectra, said bleachable components being molecules possessing vibrational spectral bands that upon exposure to light show a reduction in signal intensity. | 06-16-2011 |
20110151501 | MODULAR SYSTEM AND METHOD FOR DETECTING MICROORGANISMS - A modular automated system ( | 06-23-2011 |
20110159534 | METHOD AND CULTURE MEDIUM FOR ENHANCED DETECTION OF MYCOBACTERIUM - The present invention relates to an improved culture medium and method for the enhanced growth and detection of | 06-30-2011 |
20110159535 | PREPARATION AND USE OF NUCLEATED RED BLOOD CELL SIMULATING PARTICLES AND HEMATOLOGY CONTROL MIXTURES - The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product. The present disclosure also provides a hematology control mixture containing the nucleated red blood cell simulating particles. In addition, the present disclosure describes the use of the nucleated red blood cell simulating particles and the hematology control mixtures comprising the same, for the quality control of a blood cell analyzer. | 06-30-2011 |
20110159536 | DEVICE FOR CAPTURING OBJECT AND METHOD FOR USING THE SAME - An object of the present invention is to provide an object-capturing device which accurately detects objects such as microorganisms captured at a test site. The object-capturing device of the present invention includes a capturing dish holding a carrier, which captures objects (microorganisms), on a first side of the capturing dish. The capturing dish has a through hole extending from the first side to a second side of the capturing dish. The object-capturing device is used in a way such that, after the objects are captured with the carrier directed upward, the carrier is directed downward and reagents for detecting the objects are contacted with the objects captured on the carrier through the through hole. | 06-30-2011 |
20110177547 | Particle Sorting Using Fluid Streams - A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix. | 07-21-2011 |
20110183370 | OPTICAL IMAGING FOR IDENTIFYING CELLS LABELED WITH FLUORESCENT NANOPARTICLES - An optical detection system for identifying target bacterial cells in a food sample, comprising a first fluorescent nanoparticle dye labeling specifically the target cells. A second fluorescent dye reacts non-specifically with all bacterial cells. An imaging unit optically excites the fluorescent dyes and captures images of the sample for each of two different wavelength bands emitted as a result of the excitation of the dyes. A processing unit identifies the target cells from the sample and comprises an image processing unit for processing the images of the sample. A target cell identifier identifies the target cells in the images by detecting individual units present at a same location in both of the processed images. An output unit provides data related to the identified target cells in the sample. A method is also provided. | 07-28-2011 |
20110201049 | COMPOSITIONS FOR THE DETECTION OF MICROBIAL CONTAMINANTS - The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay. | 08-18-2011 |
20110207167 | METHOD OF ISOLATING A CELL FROM URINE - A method of isolating a cell from a urine sample includes dialyzing the urine sample with a dialysate. The dialysate is separated from the urine sample by a dialysis membrane. The dialysis membrane excludes the passage of the cell through the dialysis membrane. | 08-25-2011 |
20110207168 | Fiber-Based Biosensors for Use in Detecting the Presence of a Biologically Active Substance - Disclosed are fibers comprising one or more electrostatically attached substrates that can be used to determine the presence of a biologically active substance. Further disclosed are substrates comprising the fibers, articles of manufacture comprising the fibers and/or substrates, and methods for detecting the presence of a biologically active substance. | 08-25-2011 |
20110217729 | TARGETED CELL SEPARATION AND ENUMERATION DEVICE AND THE USE THEREOF - This disclosure describes a portable device that conveniently applies cancer patient blood sample into a test strip to determine the level of the patient's metastatic circulating tumor cells. Proper use of this device provides end users with the diagnostic and prognostic information of the cancer patient, and any effect of applied therapies. The device can also be used to screen effective drugs for any known metastatic phenotype disruption. | 09-08-2011 |
20110217730 | SYSTEMS AND METHODS FOR ANALYZING AND MANIPULATING BIOLOGICAL SAMPLES - A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell. | 09-08-2011 |
20110223631 | Detection of microorganisms with a fluorescence-based device - A device and method for detecting by fluorescence microbial growth from sample substances are disclosed. For example, a method for the detection of visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising exciting said at least one fluorescing compound with ultraviolet energy emitted from a light-emitting diode comprising wavelengths below | 09-15-2011 |
20110229929 | Arsenical Fluorescent Agents and Assays - The invention provides methods and compositions for labeling dithiol-containing analytes. | 09-22-2011 |
20110236924 | SYSTEM AND METHOD FOR PROCESSING SAMPLES - A system and method for processing samples. The system can include a loading chamber, a detection chamber positioned in fluid communication with the loading chamber, and a fluid path defined at least partially by the loading chamber and the detection chamber. The system can further include a filter positioned such that at least one of its inlet and its outlet is positioned in the fluid path. The method can include positioning a sample in the loading chamber, filtering the sample in the fluid path to form a concentrated sample and a filtrate, removing the filtrate from the fluid path at a location upstream of the detection chamber, moving at least a portion of the concentrated sample in the fluid path to the detection chamber, and analyzing at least a portion of the concentrated sample in the detection chamber for an analyte of interest. | 09-29-2011 |
20110244510 | Filtration method for detecting microbial contamination - Disclosed is a convenient sample preparation method for a medium suspected of containing contaminants, the method comprising a) passing a known volume of said medium through a filter from an influent side to an effluent side thereby concentrating the contaminants on the influent side of the filter, b) contacting the influent side of the filter with a liquid vehicle containing at least one substrate that through interaction with the contaminants each produces a detectable moiety, c) and allowing the substrate to interact with the contaminants on the influent side of the filter for a period of time, which is sufficient to allow the detectable moiety to be detected in the liquid vehicle. The method may further comprise a detection step, where the amount of detectable is determined in the liquid vehicle, preferably after the liquid vehicle has been separated from the contaminant, e.g. by passing the liquid vehicle through the filter and performing a measurement on the contaminant free liquid vehicle. Also disclosed is a kit for exercising the inventive method. | 10-06-2011 |
20110256583 | METHOD AND MEDIUM FOR ACCELERATING TARGET ANALYTE GROWTH IN A TEST SAMPLE - A reagent mixture and testing procedure for accelerating mixing of the formulation with a specimen sample being tested by effervescing when hydrolized, thereby causing an internal “stirring” of the reagent and the specimen sample. Examples of specimen samples that can be tested include nasal swabs and lesion swabs, environmental swabs, foodstuffs, and water, to mention a few. | 10-20-2011 |
20110256584 | CULTURE MEDIUM FOR CULTIVATION AND IDENTIFICATION OF BACTERIA OF GENUS PECTINATUS AND METHOD FOR TAKING SWAB SAMPLES - The present disclosure relates to a culture medium for cultivation and identification of bacteria of genus | 10-20-2011 |
20110262960 | MYCOBACTERIA CULTURE MEDIUM AND METHOD INCLUDING MYCOBACTERIA OF MYCOBACTERIUM TUBERCULOSIS COMPLEX - The present invention relates to a novel mycobacteria culture medium, particularly for mycobacteria of the | 10-27-2011 |
20110269177 | ANTIMICROBIAL AGENT AND METHOD FOR THE PRODUCTION THEREOF - Provided are antimicrobial agents produced from | 11-03-2011 |
20110269178 | FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER - Disclosed are molecules and their synthesis. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo. | 11-03-2011 |
20110269179 | COLIFORM DETECTION PROCESS AND KIT FOR USE THEREIN - A process comprises (a) providing (1) at least one sample suspected of comprising at least one coliform strain, (2) at least one culture device comprising at least one culture medium that is hydrated or hydratable, and (3) at least one particulate concentration agent that is substantially optically transparent when in contact with the culture medium in the culture device when the culture medium is hydrated; (b) placing the particulate concentration agent in contact with the sample such that at least a portion of the coliform strain is bound to the particulate concentration agent to form coliform-bound particulate concentration agent; (c) placing the coliform-bound particulate concentration agent in contact with the culture medium; (d) incubating the culture device comprising the coliform-bound particulate concentration agent in contact with the culture medium, the culture medium being hydrated; and (e) optically detecting the presence of the coliform strain without separating the coliform strain from the particulate concentration agent. | 11-03-2011 |
20110275112 | Microbial growth detector - The disclosure generally relates to a test device that detects microorganism growth by detecting a gas metabolite (e.g., carbon dioxide) produced during the growth of bacteria or other microorganism in a tested sample. The test device can contain a culture growth media separated from a detection area by a gas-permeable membrane. The gas-permeable membrane permits carbon dioxide to permeate into the detection area. The detection area includes a solidified mixture of pH indicators and a gelling agent in the form of a semi-permeable matrix. The optical properties, including the absorbance of light at various wavelengths, of the detection solution change with alterations in carbon dioxide concentration. This test device can then be placed in an incubation and optical detection instrument to monitor changes in optical properties of the detection are induced during microorganism growth in the culture medium. | 11-10-2011 |
20110275113 | MASS SPECTROPHOTOMETRIC DETECTION OF MICROBES - A method of detecting specified target microbes in different types of sample uses only one to two cultivation steps for the enrichment of the target microbes from the sample, preferably in selective culture media, combined with a mass spectrometric detection method that identifies the target microbes in mixtures with other microbes even if the target microbes account for only a small proportion of the mixture. The sample may be a food sample, a sample from bodies of water used for bathing, a soil sample, a swabbed sample, a stool sample, an impactor sample with collected aerosol particles, amongst many others. The detection method is several days faster than standard methods and less expensive. | 11-10-2011 |
20110287474 | Cultures and protocols for diagnosis of toxigenic clostridium difficile - Disclosed are culture media, protocols and kits for diagnosis of toxigenic | 11-24-2011 |
20110294158 | Rapid Detection of Bacteria Using Mass Spectrometric Analysis - Methods for the detection or diagnosis of a bacterial infection or colonisation utilising mass spectrometric analysis are provided. The methods involve short-term enrichment of samples followed by mass spectrometric analysis of biomarker profiles. Also provided are methods for preparing short-term enrichment cultures. | 12-01-2011 |
20110306085 | COMPOSITIONS AND METHODS FOR DEGRADING LIGNOCELLULOSIC BIOMASS - The present invention relates to compositions and methods of producing bioenergy products and metabolites of industrial interest from lignocellulosic biomass. More specifically, the invention describes the identification, characterization and isolation of novel bacteria having the remarkable ability to transform lignocellulosic biomass into fermentable sugars and, even more remarkably, into bioenergy products and metabolites. The invention also discloses a method to isolate such bacteria, compositions comprising such bacteria, and their uses for the modification of lignocellulosic biomass, with a view to producing bioenergy. | 12-15-2011 |
20110306086 | CELL SEPARATING METHOD - Provided is a cell separating method which suppresses physical damage to cells without using an apparatus having a complicated structure, and enables the cell separation performed by a quantitative analysis and a multi-parametric analysis and the cell separation using Hoechst staining or the like as an index. | 12-15-2011 |
20110306087 | APPARATUS TO ANALYZE A BIOLOGICAL SAMPLE - An apparatus to analyze a biological sample contained in a container, comprising an examining device able to perform an optical measurement on the biological sample, based on light-scattering technology, at least of the bacterial growth in the biological sample. The examining device is provided with emitter means able to emit a first light beam toward the container of the biological sample and sensor means able to detect at least a light beam diffused from the container of the biological sample and to transmit a relative signal, correlated to the light beam diffused, to a control unit which is able to process, directly or indirectly, the signal in order to verify at least the possible bacterial growth in the biological sample. The container is disposed along a determinate lying plane and comprises at least a containing micro-element able to contain at least a part of the biological sample and inside which a liquid culture ground is provided so as to allow bacterial growth in the biological sample. The emitter means and sensor means are able to be located on each occasion in correspondence with the containing micro-element. The sensor means comprise first sensor means disposed on the same side of the emitter means with respect to the lying plane, and second sensor means disposed on the opposite side of the emitter means with respect to the lying plane. The first sensor means are able to detect a back-scattering radiation coming from the determinate containing micro-element. The second sensor means are able to detect a forward-scattering radiation coming from the determinate containing micro-element, from which back-scattering radiation and forward-scattering radiation derive respective first and second signals transmitted to the control unit. | 12-15-2011 |
20110312021 | METHOD AND APPARATUS FOR THE NON-INVASIVE MONITORING OF GAS EXCHANGE BY BIOLOGICAL MATERIAL - The invention provides an indirect pressure sensing system for non-invasive measurement of primary pressure in a sealed container, which communicates primary pressure changes from within the container, via a flexible diaphragm, to a secondary chamber wherein there is a defined relationship between the primary and secondary pressures, which enables a pressure sensor in the secondary chamber to generate a signal representing primary pressure in the sealed container, but to remain isolated from the contents of the sealed container. The pressure sensor can provide electrical outputs representing the pressure detected, and the outputs are fed to data processing means capable of producing a measurement of primary pressure. The system can have a liquid culture of cellular material (eg. micro organisms, plant tissue cells, animal cells etc) partially filling the container, whereby the metabolism and/or growth of cellular material causes gas exchanges between liquid and headspace, which can result in primary pressure changes. | 12-22-2011 |
20110318776 | Method for identifying germs in a liquid medium - This invention relates to a method for identifying germs in a liquid medium, comprising adding a membrane detergent to the liquid medium containing components of a host infected with germs, i.e. cellular components and proteins from the extracellular environment, so as to release the germs from these components without degrading them, and in that the germs that have grown in the liquid medium are analysed by MALDI-TOF MS. | 12-29-2011 |
20120003685 | DIAGNOSTIC COMPOSITION AND ARTICLE FOR MONITORING INTRAVAGINAL INFECTIONS - The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the buffer capacities associated with vaginal secretions. The diagnostic composition provides a visible indication of vaginal infections, such as bacterial vaginosis. | 01-05-2012 |
20120003686 | CULTURE PLATE HOLDER - The present disclosure describes holder devices, testing kits that include the holder devices, and methods for using the holder devices to allow a user to dispense an aqueous test sample from a sampling device onto a culture plate device having a cover sheet, whereby the cover sheet is supported in an open position by the holder while the user dispenses the aqueous test sample onto a base member of the culture plate device. | 01-05-2012 |
20120021453 | LABEL-FREE CELL SORTING USING NEAR INFRARED EMISSION - Disclosed are methods and systems for identifying and sorting cells based on a near-infrared emission pattern of the cell in response to excitation at 630±nm. The NIR emission pattern can be used for monitoring and sorting of cells in a label-free manner, and thus provides a positive method for selecting cells, such as stem cells, for use in therapy. | 01-26-2012 |
20120021454 | RAPID FRET-BASED DIAGNOSIS OF BACTERIAL PATHOGENS - The invention comprises a substrate for detection of micro-organisms, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example X1, is a D-amino acid and the others, for example X2 and X3, may be any D- or L-amino acid. Said substrate preferably is used for the detection of | 01-26-2012 |
20120021455 | Detector Arrangement for Blood Culture Bottles With Colorimetric Sensors - A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO | 01-26-2012 |
20120021456 | METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF ANISOTROPIC CRYSTALS AND HEMOZOIN PRODUCING PARASITES IN LIQUID BLOOD - An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height riot greater than about fifteen microns (15μ); b) disposing the sample layer within the sample chamber between a polarizing filter and an analyzing filter; a) disposing the polarizing filter, sample chamber, and analyzing filter in a configuration relative to a light source such that polarized light passes through the sample, and subsequently impinges on the analyzing filter; and d) wherein polar orientations of the polarizing filter and the analyzing filter are such that the polarized light will not pass through the analyzing filter, and light passing through an anisotropic crystal disposed within the sample will pass through the analyzing filter and appear as a point of light. | 01-26-2012 |
20120028294 | HOME TEST KIT FOR DETECTING FECAL BLOOD - A home test kit for detecting fecal blood includes a scoop device for collecting a fecal sample, a luminescent for mixing with the sample, a hollow container for containing the sample, water and the luminescent, or luminol during use of the kit. A base may be provided for supporting the container during testing, and the container may include an integrally formed lid. Detection of the blood in the sample is possible because the luminescent undergoes a light-producing reaction that involves, as a reactant or catalyst, blood or blood components or products. The blood is thus visible, or glows in darkened surroundings. The kit is compact, easy to use, and formed from biodegradable material for easy disposal. | 02-02-2012 |
20120028295 | SYNERGISTIC COMPOSITION USEFUL AS MICROBIOLOGICAL GROWTH MEDIUM FOR RAPID SCREENING OF PHOSPHATE ACCUMULATING MICROORGANISMS - Screening isolates for phosphate accumulation by quantitative methods requires investment of time, labour and chemicals. There has been paucity of a medium and method for screening phosphate-accumulating microorganisms (PAOs) from the environment. Therefore, a new screening strategy is needed towards isolating effective PAOs in environments with diverse microbial populations and limited organic resources, where it is possible that PAOs are often out-competed by organisms capable of utilising available nutrients more rapidly. In view of these problems, a medium optimal for an efficient screening of P-accumulating microorganisms was developed, which is rapid and allows many PAOs to be screened. Thus, the present invention utilizes Toluidine Blue-O (TBO) a blue coloured dye, which decolorizes due drop in the concentration of phosphate in the medium, as an indicator to quickly evaluate the P-accumulating microorganisms based upon visual observations. Fast decolorization of the dye is an indicator of a superior phosphate accumulating microbe. Therefore, colorimetric reaction using PAM-TBO of the present work was further applied in a novel, extremely high-throughput manner to detect individual microbial isolates, growing on a PAM Petri plate. Adaptation of PAM-TBO assay in screening PAOs in environmental samples for microtitre plate assay enhanced the effectiveness of the assay system efficiently and effectively. | 02-02-2012 |
20120028296 | FECAL SAMPLE COLLECTION AND PROCESSING APPARATUS AND METHOD - A method for collecting and processing biological samples (e.g., fecal samples) is disclosed. The method may include obtaining a system comprising a container, a collector, and a lid. Using the collector, a user may collect a sample. The sample may be inserted within the container. The lid may be secured and the container and sample contained therewithin may be transported to a testing facility. At the testing facility, the container may be used throughout the processing of the sample. Accordingly, the risk of cross-contamination may be reduced. | 02-02-2012 |
20120034646 | DETECTION OF H. PYLORI UTILIZING UNLABELED UREA - Disclosed is a method and device for detection of | 02-09-2012 |
20120034647 | METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES - A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features. | 02-09-2012 |
20120058508 | DETECTOR FOR CHEMICAL COMPOUNDS - Systems and methods to analyze contaminants including a plurality of stages configured to detect contaminants in a sample, wherein the plurality of stages are configured to detect a plurality of contaminants at substantially the same time. | 03-08-2012 |
20120064566 | MULTIPLE PHASE FLOW SYSTEM FOR DETECTING AND ISOLATING SUBSTANCES - A multiple flow system and method for detecting substances in a fluid is provided. More specifically, a first fluid tube containing a first fluid and a second fluid tube containing a second fluid are coupled to a common fluid tube via a connector, such that alternating discrete compartments of the first fluid and the second fluid flow through the common fluid tube. The first and second fluids are immiscible. A substance detector, having a flow chamber with an internal wall, is coupled to the common fluid tube. The alternating discrete compartments of the first and second fluids flow through the flow chamber and are analyzed by the substance detector. | 03-15-2012 |
20120077221 | DETECTION DEVICE AND METHOD FOR DETECTING ANALYTE - There is provided a detection device that comprises a light source, a light sensor and an at least partially light-transmitting element that supports growth of at least one analyte selected from among fungi and bacteria. The light source, the at least partially light-transmitting element and the light sensor are positioned relative to one another and oriented relative to one another such that when the light source is illuminated, at least some of the light emitted from the light source passes through the at least partially light-transmitting element and is received by the light sensor. There is also provided a method of detecting an analyte, comprising illuminating a light source to emit light, and detecting an intensity of light that passes through an at least partially light-transmitting device that comprises an at least partially light-transmitting element that supports growth of at least one analyte selected from among fungi and bacteria. | 03-29-2012 |
20120077222 | Method and Device for Determining the Microbiological Contamination in an Environment - The method comprises providing at least one sampling plate and at least one supporting member in said environment with the supporting member being suitable for detachably receiving the sampling plate; and removing the plate from the supporting member after a period of time such that the microbiological contamination in said environment can be determined by analyzing said sampling plate. A device is provided for carrying out said method comprising the supporting member carrying one or more sampling plates, attaching means for detachably fixing the sampling plates therein and releasing means for removing of the sampling plate from the supporting member. | 03-29-2012 |
20120088265 | Mold Pathogen Detection Apparatus - The present invention is a mold pathogen detection apparatus in which an agar strip is exposed to the environment being tested for a period of time and then exposed to a non-UV light to determine the amount of light passing through the agar strip. | 04-12-2012 |
20120088266 | BIOREACTOR PROCESS FOR PRODUCTION OF HYDROGEN FROM BIOMASS - This invention relates to bioreactor processes, particularly bioreactor processes for the production of hydrogen gas from biomass, more particularly to bioreactor processes for the production of hydrogen gas employing a mixed anaerobic thermophilic bacterial consortium during the anaerobic fermentation of biomass. | 04-12-2012 |
20120094324 | SYSTEM AND METHOD FOR HIGH THROUGHPUT CELL ANALYSIS AND SORTING - A sorting methodology in which bulk analysis of samples that have a low probability of containing a rare particle is performed first. Only those samples in which the bulk analysis has detected one or more rare particles are subjected to a flow cytometry process to isolate the rare particle(s). In one embodiment, a microwell plate provides for high throughput sorting in an enclosed environment. The microwell plate comprises a plurality of wells and a microfluidic layer adapted for flow cytometry wherein particles from a given well are interrogated and sorted into other wells. The microfluidic layer advantageously includes fluid switches to permit bi-directional flow cytometry. | 04-19-2012 |
20120094325 | Microfluidic Cell Motility Assay - Certain isolated motile cells spontaneously migrate unidirectionally through a mechanically confined space, such as a microcapillary channel, in the absence of an external gradient (e.g., a chemical gradient). Assays and methods for detecting motile cells, and identifying chemical agents that inhibit cell migration, can include detecting the movement of motile cancer cells through a microcapillary channel. | 04-19-2012 |
20120094326 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 04-19-2012 |
20120107864 | MASS SPECTROMETRIC RAPID DETECTION OF SALMONELLA - The invention relates to the detection of specified, flagellated bacteria, particularly | 05-03-2012 |
20120107865 | DETECTION OF BACTERIA AND FUNGI - A method of detecting a ligase expressing micro-organism in a sample comprises steps of treating the sample under conditions that inhibit the activity of ATP-dependent ligase from mammalian cells but which do not inhibit the activity of the microbial ligases, contacting the sample or a portion of the sample with a nucleic acid molecule which acts as a substrate for ligase activity in the sample, incubating the thus contacted sample under conditions suitable for ligase activity; and specifically determining the presence and/or the amount of a ligated nucleic acid molecule resulting from the action of the ligase on the substrate nucleic acid molecule to indicate the presence of the ligase expressing micro-organism. The micro-organism may be a fungus or a bacterium or both. High pH conditions may be employed to inactivate mammalian ligases. Related kits are described. | 05-03-2012 |
20120115181 | SYSTEMS AND METHODS FOR CEREBROSPINAL FLUID COLLECTION - A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube. | 05-10-2012 |
20120115182 | MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA - The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles. The method is based on the use of relatively strong tensides to destroy the blood particles by dissolving the weak cell membranes and most of the internal structures of the blood particles; in spite of the fact that tensides are regarded as strong ionization inhibitors in MALDI and other ionization processes required for mass spectrometric measurements. This method allows unknown pathogens to be obtained in their pure form by centrifuging or filtration and to be identified on the taxonomic level of species or subspecies. Problems with DNA from high levels of leukocytes can be resolved by special measures. After sufficient cultivation, the identification in a mass spectrometric laboratory takes only half an hour. | 05-10-2012 |
20120115183 | Detector Arrangement for Blood Culture Bottles with Colorimetric Sensors - A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO | 05-10-2012 |
20120115184 | METHOD FOR THE DETECTION OF MASTITIS AND MILK QUALITY AND MASTITIS SENSOR - A mastitis sensor and a method for detection of mastitis and determination of milk quality in real time (on-line). Methods and apparatuses for the rapid non-invasive determination of the concentration of dissolved molecular oxygen in milked milk are disclosed. Mastitis sensors are disclosed that include a fiberoptic, amperometric or potentiometric device for the determination of oxygen concentration, a device for data acquisition and processing, mastitis indicator and a device that generates a signal for the automatic on-line elimination of substandard milk of infected animals to prevent the pollution of bigger quantities of milk. | 05-10-2012 |
20120122149 | Absorbent bead concentration method that eliminates the need for centrifugation - This invention is a technique that enables the concentration of cells, microorganisms, parasite eggs and cysts using absorbent beads, eliminating the need for centrifugation. | 05-17-2012 |
20120135454 | METHODS FOR SEPARATION, CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS USING SPECTROSCOPY - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The method may also be useful for the physical separation and/or enrichment of two or more different or individual microorganism species contained in a mixed test sample. The invention further provides for spectroscopic interrogation of the separated microorganism sample(s) to produce measurements of the microorganism and characterizing and/or identifying the microorganism(s) in the sample using said spectroscopic measurements. | 05-31-2012 |
20120135455 | Smart Packaging For Detecting Microorganisms - The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the growth of microorganisms in different types of products to be detected visually without having to be in direct contact with the microorganism or with the medium containing same. | 05-31-2012 |
20120135456 | METHOD AND KIT FOR DETECTION OF GUAIACOL-PRODUCING BACTERIUM - Disclosed is a method for detecting guaiacol-producing bacteria in a specimen comprising culturing the specimen or a dilution thereof on a plate of a solid medium for acidophilic bacteria comprising a compound represented by the following formula, wherein R is —H, —OH, —C(O)H, —C(O)CH | 05-31-2012 |
20120135457 | APPARATUS AND METHOD FOR THE DETECTION AND ANALYSIS OF PARTICLES IN FLUIDS - The invention relates to apparatus for the detection of particles and for particle analysis. The apparatus comprises a sample holder comprising a base and a projection extending from the base. The base includes a contact region where, in use, the surface of a fluid sample may contact the projection. The surface of at least the contact region of the projection exhibits properties that allow the surface of the contact region to be substantially wetted by a fluid sample when the apparatus is in use so that the fluid sample forms a meniscus having its apex in contact with the contact region of the projection. The invention also relates to methods for using the apparatus. | 05-31-2012 |
20120149056 | METHOD AND REAGENTS FOR DETECTING THE PRESENCE OR ABSENCE OF A TARGET SUBSTANCE IN A TEST SAMPLE - Reagent mixtures and testing procedures for detecting the presence or absence of various target substances such as aureus; vancomycin-resistant enterrococcus; Group B | 06-14-2012 |
20120149057 | METHOD FOR PROGNOSING RESPONSE TO CANCER THERAPY WITH 5, 10, 15, 20-TETRAKIS (CARBOXYPHENYL) PORPHINE - Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the cancer with a solution of TCPP to permit binding of the TCPP to components of the abnormal dysplastic or carcinomic cells, if any are present; detecting TCPP fluorescence in the sample, the presence of TCPP fluorescence being indicative that the sample contains dysplastic or carcinomic cells; at intervals during the therapy and subsequent to the therapy performing steps a-c on another sample of cells from the patient's tissue or organ being treated for the cancer; and determining if the percentage of abnormal pre-cancerous cells in the samples tested during and subsequent to the therapy are reduced as compared with the sample tested prior to the therapy, the reduction being prognostic of the patients response to the cancer therapy. | 06-14-2012 |
20120156716 | Methods For The Isolation, Accumulation, Characterization And/Or Identification Of Microorganisms Using A Filtration And Sample Transfer Device - The present invention is directed to methods, devises and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample, followed by a subsequent filtration step for isolation and/or accumulation of microorganisms. In one embodiment, a filtration and sample transfer device is used for isolation and/or accumulation of microorganisms by filtration. Once the microorganisms have been filtered for isolation and/or accumulation microorganisms, the isolated and/or accumulated microorganisms can be analyzing to acquire measurements for the characterization and/or identification of said microorganisms. | 06-21-2012 |
20120164681 | Method for Detection or Identification of Bacteria or Bacterial Spores - A method and apparatus for detecting bacteria and bacterial spores are disclosed in which a sample is assessed for the presence of bacteria and/or bacterial spores by reference to horizontally polarized fluorescent light. | 06-28-2012 |
20120164682 | METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING - A method for analyzing a blood sample residing within an analysis chamber, which sample has one or more first and second constituents, which constituents are different from one another. The method includes the steps of: a) imaging the sample containing the first and second constituents, which sample is mixed with a colorant that causes the first and second constituents to fluoresce upon exposure to light, and which colorant is also operative to absorb light, the imaging produces image signals representative of fluorescent emissions from the sample and optical density of the sample; b) determining one or more values representative of fluorescent emission from the first and second constituents; c) determining one or more values representative of optical density for the first and second constituents; and d) distinguishing the first constituents from the second constituents using the fluorescent emission representative values and the optical density representative values. | 06-28-2012 |
20120164683 | BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD - A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers. | 06-28-2012 |
20120183992 | Reagents and Methods for Classifying Leukocytes - A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent. With the reagent and method, erythrocytes are lysed rapidly and classification of leukocytes into five groups is achieved in the same channel. The reaction may be carried out at approximately between 10-40° C. and scattered light signals may be detected at two angles for measuring the classification of leukocytes into five groups. | 07-19-2012 |
20120225449 | Method and appraratus utilizing enzyme substrates producing slow diffusing fluorescent product appearances and chromogens, and use in combination with fast diffusing product appearances - A new method of rapid detection of cells, microorganisms, or other items is described using various combinations of indicator enzyme substrates which can yield fluorophoric and chromophoric appearances due to reaction with enzymes. An aspect of the invention is the use of a family of compounds producing both slow diffusing fluorophoric appearances and a family of compounds identified as dual enzyme substrates producing both fluorophoric and chromogenic appearances. | 09-06-2012 |
20120231492 | SENSOR FOR DETECTING MICROORGANISMS AND CORRESPONDING PROCESS - Microbial fuel cells generate an electrical signal when microbes enter the cells through a semipermeable membrane. By reading and analyzing the signal from one or more such fuel cells can indicate infection in people or animals, indicate pathogens growing in food or show mold growth. Insofar as different microbes have specific metabolisms, the signal may be used to determine which microbe is present. | 09-13-2012 |
20120237967 | Method for Microbiological Testing - Costly enrichment medium used for microbiological testing of nuts and other moisture-absorbing food products is conserved by saturating the product with water or other inexpensive liquid prior to contacting the product with enrichment medium. | 09-20-2012 |
20120237968 | Detector and Method for Detection of H. Pylori - An inexpensive, portable, hand held, point-of-care, non-invasive breath-analyzer for the detection of | 09-20-2012 |
20120237969 | Method of Preparing Cells Susceptible to Transmissible Spongiform Encephalopathy and the Creation of TSE Persistently Infected Cells - Disclosed is a method for preparation of transmissible spongiform encephalopathy (TSE) susceptible cells, and such cells may be efficiently used in diagnosis of TSE, etiology studies and development of novel therapeutics, etc. | 09-20-2012 |
20120244569 | QUANTUM DOT CARRIER PEPTIDE CONJUGATES SUITABLE FOR IMAGING AND DELIVERY APPLICATIONS IN PLANTS - Provided are methods for introducing a molecule of interest into a plant cell having a cell wall by using a QD-peptide conjugate having a quantum dot (QD) with one or more cell penetrating peptides (CPPs). Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall. | 09-27-2012 |
20120244570 | METHODS FOR DETERMINING MICROBIAL CONTAMINATION OF ALLOGRAFT PRODUCTS - A method for determining microbial contamination of allograft products comprises providing an extraction vessel having an outer container and a removable inner basket, place the allograft product into the inner basket, providing an abstraction fluid in the outer container of the extraction vessel, positioning the inner basket in the outer container, so that the allograft product and the inner basket is submerged in the extraction fluid and agitating the extraction fluid for a predetermined amount of time and analyzing the extraction fluid from microbial contamination. | 09-27-2012 |
20120252057 | METHOD AND DEVICE FOR DETECTING TUMOROUS LIVING CELL TISSUE - The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension D | 10-04-2012 |
20120252058 | System and Method for the Assessment of Biological Particles in Exhaled Air - A system and method for the deposition and analysis of a sample comprising exhaled particles. The sample may be deposited on a substrate and regions of interest comprising exhaled particles may be targeted using autofluorescence. Regions of interest comprising exhaled particles may then be interrogated to thereby generate a spectroscopic data set. This spectroscopic data set may be compared to a reference data set associated with at least one of the following: a known disease state, a known metabolic state, a known inflammatory state, a known immunologic state, a known infectious state, and combinations thereof. | 10-04-2012 |
20120252059 | FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS - The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumours in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: R | 10-04-2012 |
20120252060 | Self-Renewing Single Human Hematopoietic Stem Cells, an Early Lymphoid Progenitor and Methods of Enriching the Same - This invention relates to human hematopoietic stem cells. Specifically the invention relations to the identification of single human hematopoietic stem cells capable of long-term multilineage engraftment and self-renewal. The invention also relates to an early lymphoid progenitor with monocytic potential, including dendritic cell potential. | 10-04-2012 |
20120252061 | NOVEL YEAST STRAINS FOR THE PRODUCTION OF ALCOHOL - The present invention relates to novel yeast strains intended for alcohol production. | 10-04-2012 |
20120258487 | MICROFLUIDIC PLATFORM FOR SYNTHETIC BIOLOGY APPLICATIONS - This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of said biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to for a sequenced order of droplets carrying different components of said biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of said biological construct to permit said components to react with each other in one or more reactions contributing to the assembly of said biological construct. | 10-11-2012 |
20120258488 | Systems and Methods for Electrophysiological Activated Cell Sorting and Cytometry - Provided herein are methods and systems for non-genetic, label-free cell purification (i.e., cell cytometry and sorting), which classifies cells based on their spontaneous electrophysiological response or their electrophysiological response to a stimulus. For example, in one embodiment, there is provided a method of cell sorting comprising: stimulating a cell with a stimulus; sensing a response evoked by the cell based on the stimulus; identifying a phenotype of the cell based on the evoked response; and sorting the cell based on its phenotype. In one embodiment, the stimulus may be an electrical stimulus, a mechanical stimulus, an optical stimulus, a thermal stimulus, a chemical stimulus, or any combination thereof. The cell phenotype may be, for example, cardiomyocytes, neurons, smooth muscle cells, or pancreatic beta cells. | 10-11-2012 |
20120264163 | APPARATUS AND METHOD FOR DETECTING BACTERIAL GROWTH BENEATH A WOUND DRESSING - An apparatus and method are provided for visually monitoring, detecting, and/or determining the presence, absence, and/or growth of harmful or potentially harmful bacterial microorganisms beneath a wound dressing, in one example used to cover an indwelling central venous catheter or other catheter. A bacteria detection apparatus includes a barrier membrane, a permeable membrane for placement proximate a wound or a catheter insertion site, and an indicator between the barrier membrane and the permeable membrane for indicating the presence of bacteria proximate the permeable membrane. A method of using a bacterial growth detection apparatus is also provided. | 10-18-2012 |
20120264164 | LYMPH NODE SPECIMEN COLLECTION KIT AND METHOD OF PATHOLOGICAL ANALYSIS FOR LUNG CANCER DIAGNOSIS USING SUCH A KIT - A unique system for the correlation between removed lymph nodes for lung cancer diagnosis and pathological analysis thereof is provided. Such a system includes the removal of certain lymph nodes from a suspected or known lung cancer patient with subsequent categorization thereof and placement within a properly divided and labeled specimen collection kit. Through the utilization of such a separation and placement allows and facilitates understanding and non-verbal communication between a surgeon and a pathologist in order to denote the location of the removed lymph nodes in relation to a known or suspected lung cancer tumor or growth. The overall diagnostic method, including the important communicative properties accorded both the particular surgeon and pathologist, is encompassed within this invention, as well as the specific collection specimen kit that permits the surgeon proper distinction of specific removal lymph nodes in relation to their location within the patient's body. | 10-18-2012 |
20120276578 | Phasor Method to Fluorescence Lifetime Microscopy to Discriminate Metabolic State of Cells in Living Tissue - “A label-free imaging method to monitor stem cell metabolism discriminates different states of stem cell as they differentiate in a living tissues. We use intrinsic fluorescence biomarkers and the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). We identify and map intrinsic fluorophores such as collagen, retinol, retinoic acid, flavins, nicotinamide adenine dinucleotide (NADH) and porphyrin. We measure the phasor values of germ cells in | 11-01-2012 |
20120276579 | ORGANIC COMPOUNDS - The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. | 11-01-2012 |
20120276580 | MICROORGANISM CONCENTRATION PROCESS AND CONCENTRATION AGENT FOR USE THEREIN - A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing an adsorption buffer-modified inorganic concentration agent that is prepared by a process comprising (1) contacting at least one inorganic concentration agent with at least one cation-containing salt solution, so as to wet at least a portion of the inorganic concentration agent and (2) drying the resulting at least partially wet inorganic concentration agent; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the adsorption buffer-modified inorganic concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the adsorption buffer-modified inorganic concentration agent. | 11-01-2012 |
20120276581 | METHOD FOR PRESERVING CANCELLOUS BONE SAMPLES AND PRESERVED CANCELLOUS BONE TISSUE - The claimed subject matter is based on the finding that it is possible to cryopreserve cancellous bone tissue with viable cells (after reconstitution by either thawing or rehydration), the viability after reconstitution being comparable to that of a fresh sample (without freezing) and of beneficial value for use in, for example, transplantation. Thus, provided is a method for cryopreserving a cancellous bone sample. The cryopreserved cancellous bone sample can be in dry form, for example, lyophilized. Also provided is a cryopreserved, in dry form, bone sample and the use of a cryopreserved bone sample; a method for identifying such cryopreserved cancellous bone tissue and uses thereof. | 11-01-2012 |
20120282649 | FLUORESCENCE DETECTING APPARATUS, FLUORESCENCE DETECTING METHOD, AND FLUORESCENCE SIGNAL PROCESSING METHOD - Disclosed herein is a fluorescence detecting apparatus. The fluorescence detecting apparatus includes a light-receiving element that receives fluorescence emitted from an object to be measured irradiated with laser light modulated at a predetermined frequency and outputs a fluorescence signal at an adjusted output level; a signal processing unit that mixes the outputted fluorescence signal and a modulation signal with the frequency to generate fluorescence data including information about phase and intensity; and an analyzing device that calculates a first phase shift of the fluorescence emitted from the object to be measured with respect to the modulation signal, calculates a second phase shift by correcting the calculated first phase shift depending on conditions for adjusting the output level, and calculates a fluorescence relaxation time of the fluorescence emitted from the object to be measured using the calculated second phase shift. | 11-08-2012 |
20120288888 | MICROBIAL DETECTION ARTICLE - The disclosure provides an article for the detection of a microorganism in a liquid sample. The article comprises a microporous membrane and a barrier layer to selectively regulate the contact between the sample and a detection reagent. A method of use is also provided. | 11-15-2012 |
20120295299 | Method and apparatus for rapidly analyzing microorganisms using petri plates - A growth plate or Petri plate and a method for detection and identification of microorganisms by specific or non-specific staining of colonies or microcolonies is described. Analytical substances (chromogenic or fluorogenic substrates, biochemical dyes, dyes indicators of pH, antibiotics and other biological active substances) are applied to the lower surface of a nutrient agar layer. The substances diffuse in the agar, reach cells and react with them. Because colonies or microcolonies are not removed from the media, they retain their shape, color, size and other useful characteristics for analytical purposes. | 11-22-2012 |
20120301916 | Growth Medium For The Detection Of Microorganisms By Fluorescence Allying A Fluorogenic Substrate And A PH-Sensitive Fluorophore - The invention relates to a growth medium allying a fluorogenic substrate and a pH-sensitive fluorophore, in particular the combination of 4-methylumbelliferone (4-MU) and derivatives of fluorescein. This growth medium is used for the detection by fluorescence of microorganisms by coupling the fluorescence measurements relating to the pH-sensitive fluorophor and the fluorescence measurements relating to the activation of the fluorogenic substrate(s) by the microorganisms. | 11-29-2012 |
20120309047 | Color Changing Polymer Films for Detecting Chemical and Biological Targets - A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte. | 12-06-2012 |
20120309048 | DIAGNOSTIC APPARATUS - A diagnostic apparatus ( | 12-06-2012 |
20120315664 | ASSEMBLY AND METHOD FOR THE FILTRATION OF A LIQUID AND USE IN MICROSCOPY - An assembly and method are disclosed for the filtration of a liquid and the use thereof, wherein a supporting body is designed in a recess of a carrier and a filter membrane lies flat on the supporting body. The filter membrane and the supporting body are designed to be permeable to liquids and thus serve as filters, in particular for filtering tumor cells from blood. The carrier can having standard shapes of an object carrier for microscopy and the filtration residue on the filter membrane can be easily handled and examined in the microscope. As a result of the filter membrane lying level on the supporting body, the filtration residue can be particularly well examined microscopically. | 12-13-2012 |
20120315665 | METHOD FOR DETERMINING A MARKER IN SMALL VOLUME OF A SAMPLE OF A BODILY FLUID - The invention refers to a method for determining a marker in a small volume of a sample of a bodily fluid, the method comprising the steps of: providing a flow test element having a plurality of functional zones ( | 12-13-2012 |
20130004986 | Use of luminescent Ir(III) and Ru(II) complexes - The present invention relates to the use of luminescent Ir(III) and Ru(II) complexes and their application in electro-chemiluminescence and bio-labelling. The use refers to the labelling and detection of biomolecules. | 01-03-2013 |
20130004987 | APPARATUS AND METHOD FOR IMPROVED OPTICAL DETECTION OF PARTICLES IN FLUID - A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfluidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process. | 01-03-2013 |
20130004988 | DISPENSING OF A DIAGNOSTIC LIQUID ONTO A DIAGNOSTIC REAGENT - Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods. | 01-03-2013 |
20130011872 | STABLE ISOTOPIC BIOMARKER MEASUREMENT FOR THE DETECTION OF CANCER AND THE DETERMINATION OF EFFICACY OF TREATMENT IN DIAGNOSED CANCER PATIENTS - The present invention relates to a method of detecting the presence of cancer cells in an animal such as a human or other mammal, comprising administering a measured volume of air to the subject wherein | 01-10-2013 |
20130017569 | CULTURE MEDIUM, METHOD FOR CULTURING LISTERIA, AND METHOD FOR DETECTING LISTERIA - There are disclosed a culture media and culture supplements for cultivating microorganisms, including | 01-17-2013 |
20130017570 | METHOD FOR MONITORING STATE OF DIFFERENTIATION IN STEM CELL - A method for monitoring the differentiation state of a stem cell, includes a step (A-1) of culturing a stem cell into which a fusion gene of a promoter region of a differentiation state detection marker gene and a luminescent protein-coding gene is introduced, a step (A-2) of culturing the stem cell under a differentiation-inducing condition after the step (A-1), and a step (A-3) of capturing images of luminescence emitted by expression of the luminescent protein-coding gene in the stem cell, over at least a given period of the steps (A-1) to (A-2). | 01-17-2013 |
20130023007 | IDENTIFYING AND MEASURING RETICULOCYTES - Methods and systems for identifying reticulocytes in a blood sample deposited on a substrate include: illuminating the sample with incident light at two different wavelengths, obtaining a two-dimensional image of the sample corresponding to a first one of the wavelengths, and obtaining a two-dimensional image of the sample corresponding to a second one of the wavelengths; analyzing the images to identify a set of representative red blood cells; determining an area of each of the red blood cells in the set; determining a color value of each of the red blood cells in the set; and, for each one of the red blood cells in the set, identifying the red blood cell as a reticulocyte if the area of the red blood cell exceeds an area cutoff value and the color value of the red blood cell is less than a color cutoff value. | 01-24-2013 |
20130029372 | B-CELL ANTIGEN PRESENTING CELL ASSAY - Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject. | 01-31-2013 |
20130029373 | METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING - A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values. | 01-31-2013 |
20130040337 | BLOOD ANALYSIS APPARATUS AND BLOOD ANALYSIS METHOD - As a result of acquiring visible absorption spectra of red blood cells and analyses of the spectra, inventors of the present disclosure have discovered the fact that echinocytes show a characteristic spectrum pattern having an absorption peak in a wavelength region of 450 to 490 nm between Soret and Q bands. Then, the present disclosure provides a blood analysis apparatus having an analysis section for detecting the absorption peak of a visible absorption spectrum acquired for blood. In accordance with this blood analysis apparatus, on the basis of the absorption peak, it is possible to detect echinocytes contained in blood. | 02-14-2013 |
20130040338 | DEVICE FOR CAPTURING OBJECT AND METHOD FOR USING THE SAME - Provided is a device for capturing object, wherein a carrier which captures substances to be detected and is made to be dividable into plural portions, is placed with the plural dividable portions arranged in sections. The carrier includes a count analysis carrier and an identification analysis carrier respectively arranged in sections in a first dish half and a second dish half which are obtained by dividing a capturing dish. | 02-14-2013 |
20130045501 | Detection Device for Detecting Analytes in Liquid Specimen - A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided. | 02-21-2013 |
20130045502 | Method for Detection or Identification of Bacteria or Bacterial Spores - A method and apparatus for detecting bacteria and bacterial spores are disclosed in which a sample is assessed for the presence of bacteria and/or bacterial spores by reference to horizontally polarized fluorescent light. | 02-21-2013 |
20130065269 | FINE PARTICLE MEASURING APPARATUS - A fine particle measuring apparatus is provided. The fine particle measuring apparatus includes a detection unit configured to detect light emitted from a fine particle and a processing unit having a memory device storing instructions which when executed by the processing unit, cause the processing unit to calculate a corrected intensity value of the detected light and generate spectrum data based on the corrected intensity value. | 03-14-2013 |
20130071875 | METHOD AND SYSTEM FOR THE DETECTIONS OF BIOLOGICAL OBJECTS - The present invention provides a method for identifying biological objects on a substrate; the method comprises: (i) illuminating the substrate carrying the biological objects with a light beam; (ii) acquiring at least one optical image of the illuminated substrate; the light beam comprises a wavelength band, the wavelength band is selected to induce at least one optical aberration in the optical image of the illuminated substrate; the optical aberration is predetermined as characterizing the biological objects; and (iii) processing said at least one optical image to provide a value or a combination of values indicative of presence or absence of said at least one optical aberration; said value or combination of values permitting detection or identification of the biological objects on said substrate. The invention also provides a processing unit, a system and a database for use in connection with the method of the invention. | 03-21-2013 |
20130078667 | METHODS FOR DETECTING AND COLLECTING CIRCULATING TUMOR CELLS - The present invention is directed towards methods of expanding circulating tumor cell populations and methods of detecting circulating tumor cells in a sample. | 03-28-2013 |
20130078668 | METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF INTRAERYTHROCYTIC PARASITES - An apparatus and method for determining the presence of an intraerythrocytic organism within a sample of liquid whole blood is provided. The method includes the steps of a) creating an image of the sample quiescently residing within a sample chamber; b) evaluating the image for the presence of at least one red blood cell within the image containing at least one first region of decreased hemoglobin content and/or hemoglobin concentration within the red blood cell, which red blood cell has an otherwise homogenous distribution of hemoglobin; and c) determining the presence of an intraerythrocytic organism within the sample using the evaluation of the image. | 03-28-2013 |
20130078669 | Method And Devices For The Cross-Referencing Of Identification Of Tissue Slice Supports For Microtomised Analytical Samples - The invention relates to a method and device for the cross-referencing of identification ( | 03-28-2013 |
20130084597 | COMPRESSED GAS MICROBIAL TEST UNIT - Provided is a microbial test unit for detecting microbes in a compressed gas. The microbial test unit includes a decompression region and a sampling region in fluid communication with the decompression region and separated from the decompression region by a plate. The decompression region and the sampling region define a flow path. An inlet communicates with the decompression region such that compressed gas entering the decompressing region is incident on the plate for effectuating decompression of the gas prior to the gas passing into the sampling region. The microbial test unit may be used in conjunction with a growth medium substrate to form a microbial test system. The microbial test unit provides the ability to test compressed gas directly input to the unit due to positive pressure from the compressed gas pushing the microbes onto the microbial growth substrate. | 04-04-2013 |
20130084598 | Method for Detecting Clusters of Biological Particles - The invention relates to a method for detecting clusters of biological particles ( | 04-04-2013 |
20130089887 | Method for Rapid Detection and Identification of micro-colonies using impregnated porous material - This invention describes method for rapid detection and identification of colonies and micro-colonies of microorganisms growing on the surface of certain nutrient agar under certain porous material(s) impregnated by chromogenic and/or flurogenic substrates and supportive substances. Growth in the space between nutrient agar and impregnated porous material allows limiting the negative influence of unfavorable substrates and substances and allows to reveal color or fluorescence spots at early stage of micro-colony growth. | 04-11-2013 |
20130089888 | System and Method for Nonlinear Optical Devices - Systems for enhancing the sensitivity of detecting an optical signal using nonlinear optics and method of performing the same. In one embodiment, a single-photon detection system includes an optical amplifier realized in a waveguide, and a photodetector coupled to an output of the optical amplifier. A light detection and ranging system includes the optical amplifier coupled to an optical source and one photodetector. In another embodiment, a photodetection system includes a plurality of optical frequency converters, coupled to an optical source, that sequentially convert a wavelength of photons of the optical source to a final wavelength, and a single-photon photodetector coupled to the optical frequency converters to detect single photons produced by the optical source. In another embodiment, an optical sensor includes an optical pump, and a transducer including an optical ring cavity coupled to the optical pump and configured to utilize optical four-wave mixing to detect an external stimulus. | 04-11-2013 |
20130089889 | Aggregation Induced Emission Active Cytophilic Fluorescent Bioprobes for Long-Term Cell Tracking - Fluorescent bioprobes comprising fluorogen formed nanoparticles comprising fluorogens with aggregation-induced emission (ATE) properties, which can be used for long-term cell tracking. The fluorogens are nonemissive in organic solution but become highly emissive when aggregated in aqueous solution. The fluorescent molecules can readily pass through cell membranes, stain only the cell cytoplasm, and form highly emissive nanoaggregates in aqueous media without any obvious cytoxicity in the living cells. Furthermore, the molecules can be retained inside the cells without noticeable leakage to the outside. Therefore, these ATE-based compounds can be used as selective and cell-compatible fluroescent bioprobes for long-term live cell tracking and imaging. | 04-11-2013 |
20130089890 | APPARATUS AND METHOD FOR ANALYZING A CONTAMINATED SURFACE - An apparatus ( | 04-11-2013 |
20130095519 | BIOLOGICAL TISSUE ANALYSIS BY INVERSE SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY - A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μ | 04-18-2013 |
20130095520 | METHOD FOR DETECTION OF UROTHELIAL CANCER - It is to provide a method for detecting urothelial cancer simply and with high accuracy. It is a method for detecting urothelial cancer comprising administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these to a test subject, collecting urine from the test subject, and detecting the presence of fluorescence or amount of fluorescence in the collected urine. | 04-18-2013 |
20130102024 | OPTICAL FLUORESCENCE DUAL SENSORS AND METHODS OF PREPARING AND USING THEM - The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them. | 04-25-2013 |
20130102025 | METHODS AND COMPOSITIONS FOR IDENTIFYING A CELL PHENOTYPE - The present invention is directed to a method of identifying cancerous or precancerous cells suspended in a liquid carrier, such as, a biological fluid. | 04-25-2013 |
20130102026 | Culture medium and a method for detection of parasites - This invention relates to a culture medium, a kit containing the culture medium and to a method for detection of a parasite such as | 04-25-2013 |
20130109050 | MICROBEAD KIT AND METHOD FOR QUANTITATIVE CALIBRATION AND PERFORMANCE MONITORING OF A FLUORESCENCE INSTRUMENT | 05-02-2013 |
20130109051 | METHOD FOR DETECTING MICROORGANISMS, DEVICE FOR DETECTING MICROORGANISMS AND PROGRAM | 05-02-2013 |
20130109052 | STERILITY TEST METHOD AND TOTALLY ENCLOSED BACTERIAL AMPOULE INCUBATOR USED BY IT | 05-02-2013 |
20130122537 | INTEGRATED OPTICAL SENSOR - Optical sensors for use in examining and analyzing a fluid material are described. The optical sensors include a channel configured to transport a fluid material to be examined and analyzed, a first waveguide positioned adjacent to the channel and configured to guide radiation through the channel and a first tunable grating defined on the first waveguide and configured to variably define a cavity for selecting a first wavelength of the radiation. | 05-16-2013 |
20130122538 | Dynamic Light Scattering for in vitro Testing of Bodily Fluids - A method of diagnosing a pathological condition by detecting microparticles in a sample of bodily fluid using dynamic light scattering (DLS) is disclosed. The detection of microparticles in the bodily fluid by DLS may be used as an indicator of existing disease, to evaluate a risk of disease, as well, as to monitor the efficacy of a treatment for disease. | 05-16-2013 |
20130122539 | MICROSIEVE FOR CELLS AND PARTICLES FILTRATION - It is disclosed a microsieve comprising two layers, wherein the first layer is a membrane layer having a plurality of micropores contained therein and a thickness of about 10 μm to about 100 μm, and the second layer is a membrane support layer having a plurality of openings contained therein and a thickness of about 100 μm to about 500 μm, wherein the openings are larger in diameter than the micropores, and wherein at least one of the membrane layer or membrane support layer is formed of a SU-8 photoresist material. | 05-16-2013 |
20130130306 | ZN (II) BASED COLORIMETRIC SENSOR AND PROCESS FOR THE PREPARATION THEREOF - A colorimetric chemosensor molecule having a aza-macrocycle Zn (II)-complex (L.Zn) (Scheme 1, Formula 1A) which can recognize selectively and efficiently ATP (Adenosine triphosphate), a biologically significant triphosphate in aqueous medium at pH 7.4 is described. Since ATP is the source of energy in living organisms, L.Zn (Scheme 1, Formula 1A) can also be used as a staining agent in the living cells through binding to ATP, generated in situ during the metabolic process. | 05-23-2013 |
20130130307 | CELL OBSERVATION DEVICE AND CELL OBSERVATION METHOD - A cell observation device is provided with a reflection interference shutter | 05-23-2013 |
20130130308 | PROCESS FOR DIRECTLY MEASURING MULTIPLE BIODEGRADABILITIES - A method for measuring the biodegradability of organic substrates by the fluorescent and/or colorimetric detection of the microbial activity generated by the addition of organic substrates to a mixture of microorganisms. | 05-23-2013 |
20130137134 | METHOD AND SYSTEM FOR DETECTING AND MONITORING HEMATOLOGICAL CANCER - A method for diagnosis of a hematological malignancy of a subject is provided. The method comprises obtaining a second derivative of an infrared (IR) spectrum of a population of mononuclear cells by analyzing the population of mononuclear cells by infrared spectroscopy, and based on the second derivative of the infrared spectrum, generating an output indicative of the presence of a hematological malignancy. Other applications are also described. | 05-30-2013 |
20130137135 | COMPOSITIONS AND METHODS FOR LEUKOCYTE DIFFERENTIAL COUNTING - The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population. | 05-30-2013 |
20130143258 | DIAGNOSIS OF CANCER - A method is provided comprising, obtaining an infrared (IR) spectrum of a Peripheral Blood Mononuclear Cells (PBMC) sample by analyzing the sample by infrared spectroscopy; and based on the infrared spectrum, generating an output indicative of the presence of a solid tumor or a pre-malignant condition. Other embodiments are also provided. | 06-06-2013 |
20130143259 | Device For Microbiological Analysis - The device for the microbiological analysis of a support adapted to contain microorganisms marked by a fluorophore agent, said agent being adapted to absorb light energy with an absorption spectrum ( | 06-06-2013 |
20130143260 | ALGA IN WHICH PRODUCTION OF PHOTOSYNTHETIC PRODUCTS IS IMPROVED, AND USE FOR SAID ALGA - Provided are an alga in which productivity of a photosynthate is increased, and use of the alga. The alga of the present invention has an increased glutathione concentration in its chloroplast. A method of the present invention for producing biomass is a method for producing biomass with the use of the alga of the present invention or an alga produced by a method of the present invention for producing an alga. | 06-06-2013 |
20130149738 | MICROBIAL DETECTION SYSTEM AND METHODS - The disclosure provides culture devices and methods for a microorganism in a sample. The devices include a base member, a cover sheet, an adhesive layer coupled to the base member or the cover sheet, and a cold water-soluble gelling agent disposed on the base member; wherein the devices are substantially optically transmissive when the gelling agent is hydrated with a clear liquid. Methods of use include detecting or enumerating microorganisms. The methods further provide for detecting a microorganism by detecting the presence or size of an abiogenic gas bubble ( | 06-13-2013 |
20130157305 | METHOD AND SYSTEM FOR EVALUATION OF GRAFTS - A method and system for evaluating the competence for transplantation of a graft sample containing cells capable of multinucleation are provided. In one form, the method includes determining multinucleating ability as an indicator representing the capacity for multinucleation of the cells capable of multinucleation. | 06-20-2013 |
20130164776 | METHOD USED IN A HUMAN OR ANIMAL FAECES SAMPLE PROCESSING SYSTEM, AND A SAMPLE PROCESSING SYSTEM - A sample processing system, and a method in relation thereto, adapted to automatically process a sample, e.g. a faecal sample, prior to the analysis of the sample. The system comprises a sample container for collecting a sample, and a control unit comprising a stored processing recipe that includes parameters to be used to automatically perform the processing of the sample. The control unit is adapted to generate robot control signals, obtained from said processing recipe, to be applied to a robot arranged to move the sample container between different units of the system and to generate control signals to a specific unit when the sample container is about to be treated by that unit. The robot is arranged to automatically move the sample container to: a weighing unit (optional) to determine the weight of the sample; a buffer supply unit to add buffer where the buffer amount can be predefmed or depend on the weight of the sample; a homogenization and mixing unit to homogenize and mix the sample in the buffer, preferably by using sonication by ultrasound. In addition the sample container is preferably moved to: a centrifuge to centrifuge the container in order to produce a clear supernatant; a transfer unit in order to transfer a part of the supernatant to a secondary container, the transferred volume is predefined, or related to the weight of the sample and/or related to the amount of buffer previously added; and if needed, the buffer supply unit adds buffer to the secondary container in order to dilute the sample solution to the desired final concentration. | 06-27-2013 |
20130164777 | Magnetic Flow Cytometry for Individual Cell Detection - The disclosure relates to flow cytometry. A method for precise individual cell detection and cell measurement of cells in the flow is disclosed. A pair of magnetoresistive components are used to produce a characteristic measuring signal profile from which the following information can be obtained: number of measurement deviations, measurement deviation distances, measurement deviation amplitudes, measurement deviation direction and measurement deviation direction sequence. The flow speed and the cell diameter can also be determined. Also, the signal noise ratio can be determined using the measurement deviation amplitude | 06-27-2013 |
20130171685 | METHOD AND APPARATUS FOR CHARACTERIZING BIOLOGICAL OBJECTS - In order to quantitatively characterize biological objects, for example individual cells, a stimulus is applied to a biological object in a contactless fashion. A measurement and a further measurement are performed on the biological object in order to ascertain a response of the biological object to the stimulus, wherein the measurement and the further measurement comprise detecting Raman scattering on and/or in the biological object and/or capturing data using digital holographic microinterferometry (DHMI). The biological object is characterized according to a result of the measurement and is sorted if needed. The stimulus can be applied by means of a laser beam that creates optical tweezers or an optical trap, by means of ultrasonic waves or an electric or magnetic radio frequency field. | 07-04-2013 |
20130171686 | METHOD OF TREATING MINE-INFLUENCED WATER AND SOIL - The present invention is directed to a method of trans-seasonal bioremedial treating of mine-influenced water and soil (MIWAS) in situ with microorganisms for removal of contaminants containing heavy metals compounds. The method comprises the steps of: a) sampling indigenous microorganisms from the MIWAS site being treated; b) identifying and/or isolating indigenous microorganisms that consume selected compounds to be treated in the MIWAS; c) propagating at least one of the indigenous microorganisms identified or isolated in step b); and d) reintroducing propagated microorganisms either on the soil surface or subsurface at the MIWAS site together with a source of nutrients and a carbon source for the microorganisms; wherein when the microorganisms, nutrients, and carbon source are reintroduced on the soil surface, they are subsequently buried. | 07-04-2013 |
20130171687 | DEVELOPMENT OF A DETECTION MICROSYSTEM - This invention relates to a device for detecting fungal contamination in an interior environment, including:
| 07-04-2013 |
20130171688 | STERILISATION INDICATOR - A sterilization indicator having a compound that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye, in thermal contact with the compound. | 07-04-2013 |
20130171689 | CAPTURE OF MICRO-ORGANISMS - Micro-organisms, including fungi, viruses and bacteria such as | 07-04-2013 |
20130177936 | METHOD OF CANCER DIAGNOSIS USING THE ANALYSIS OF ISOPOPES - Disclosed is a method of diagnosing cancer on the basis of the quantitative analysis of blood or tissue isotopes. The method can accurately diagnose cancer even when it is too small for current conventional technology to diagnose. | 07-11-2013 |
20130177937 | CONTAINER, A CLOSURE FOR A CONTAINER, AND A BASE FOR A CONTAINER - A container, comprising: a body; and, a closure; wherein the closure has a lid hinged to a ring mounted on the body, the lid moveable from an open position to a closed position; wherein the lid has a tab hinged thereto for: inserting into and engaging a slot formed in the ring as the lid is moved to the closed position from the open position to thereby lock the lid in the closed position; or, receiving and engaging a pin head of a pin mounted on the ring in a hole formed in the tab to thereby hold the lid in the closed position, the pin configured to detach from the ring when the tab and lid are returned to the opened position. | 07-11-2013 |
20130177938 | COLLECTION BROTHS FOR MICROORGANISMS - A collection broth used for recovering microorganisms on a surface is provided. The collection broth includes a buffering system and a neutralization system. All components of the collection broth are both food-grade and hypoallergenic. | 07-11-2013 |
20130177939 | OPTICAL SENSOR AND METHOD FOR INDICATING THE AGE OR QUALITY OF A NATURAL PRODUCT - The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their use. | 07-11-2013 |
20130183711 | LIQUID CRYSTALS WITH SWITCHABLE WETTABILITY FOR CELL SORTING - Disclosed are methods and apparatuses for identifying and sorting cells based on the cells' response to an external stimulus. Cellular adherence to liquid crystals with tunable wettability is measured before and after an induced change in the liquid crystal wettability. The cell-based liquid crystal reorientation can be measured and used for monitoring and sorting of cells in a label-free manner, and thus provides a positive method for selecting cells, such as stem cells, for use in tissue engineering applications. | 07-18-2013 |
20130189728 | Identification of pathogens in body fluids - Identification of infectious pathogens, particularly viruses, bacteria and other microorganisms is effected with a method whereby pathogens of acute infections can be identified, without first culturing them in external nutrient media, by mass spectrometric measurement of their protein profiles obtained from pathogens directly precipitated from body fluid into pellets by centrifuging. With this method, pathogens which cause acute infections can be identified in less than one hour. | 07-25-2013 |
20130196366 | Method and Culture Medium for Enhanced Detection of Mycobacterium - The present invention relates to an improved culture medium and method for the enhanced growth and detection of | 08-01-2013 |
20130196367 | MODULATORS OF CANDIDA HYPHAL MORPHOGENESIS AND USES THEREOF - The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof. | 08-01-2013 |
20130196368 | Electrophysiological Recording System and Methods of Using Same - Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment. | 08-01-2013 |
20130203107 | METHOD FOR MEASURING THE AREA OF A SAMPLE DISPOSED WITHIN AN ANALYSIS CHAMBER - A method for determining the area of an analysis chamber covered by a biologic fluid sample quiescently residing within the chamber is provided. The chamber has a first panel with an interior surface, and a second panel with an interior surface, both of which panels are transparent. The method includes the steps of: a) illuminating the sample residing within the analysis chamber at one or more wavelengths operable to highlight interfaces between the sample and air, and to highlight a constituent within the sample; b) imaging the sample along the one or more wavelengths, and producing image signals representative of the interaction of the one or more wavelengths with the sample; c) determining a location of at least one interface between the sample and air, using the image signals; d) determining a location of one or more constituents within the sample relative to the at least one sample-air interface using the image signals; and e) determining an area of the chamber containing the sample, using the location of the one or more constituents and the at least one sample-air interface. | 08-08-2013 |
20130210064 | MAGNETOTACTIC ALGAE AND METHODS OF USE - Disclosed herein are magnetotactic algae, such as algae cells that include magnetic nanoparticles. In some examples the magnetotactic algae express a nucleic acid molecule encoding a bacterial MagA ferrous transporter, a nucleic acid molecule encoding a bacterial Mms6 magnetite binding protein, or both. Also disclosed herein are methods for producing magnetotactic algae and methods of producing biofuel or magnetic nanoparticles utilizing magnetotactic algae. Further disclosed herein are methods of enriching a population of magnetotactic algae cells (for example, increasing the number of magnetotactic algae cells in a population of algae cells). In further embodiments, disclosed herein are methods of selecting a transformed algae cell. | 08-15-2013 |
20130210065 | TETRAZOLIUM COMPOUND FOR DETECTING MICROORGANISMS, REAGENT FOR DETECTING MICROORGANISMS AND METHOD FOR DETECTING MICROORGANISMS - The object of the present invention is to provide a compound used in a reagent for detecting microorganisms, by which microorganisms can be rapidly and reliably detected without requiring any special instrument, the reagent for detecting microorganisms, and a method for detecting microorganisms. The object can be achieved by a tetrazolium compound represented by general formula (I) below: | 08-15-2013 |
20130210066 | APPARATUS AND METHOD FOR EARLY DIAGNOSIS OF CELL DEATH - An apparatus for measuring through optical means temporally resolved, optical properties, and/or phenotypes, linked to cellular homeostasis. Those temporal measurements enable the detection of cell regulation through various channels linked to homeostasis, in order to assess cell viability or early cell death through rapid diagnostic. | 08-15-2013 |
20130210067 | METHOD OF DETECTING A BIOLOGICAL ACTIVITY - The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative. | 08-15-2013 |
20130210068 | SUBSTRATE USED FOR CELL MIGRATION ASSAYS AND METHOD FOR CELL MIGRATION ASSAYS - This invention provides a means for cell migration assays by regulating the cells adhered to a substrate so that they migrate to a given region, which is a substrate used for cell culture comprising: a base material comprising a conductive region and an insulating region provided thereon and cell-adhesive regions and non-cell-adhesive regions provided in the conductive region and the insulating region, respectively, wherein a cell-adhesive region is positioned adjacent to a non-cell-adhesive region in the conductive region, and a cell-adhesive region is positioned adjacent to a non-cell-adhesive region in the insulating region. | 08-15-2013 |
20130210069 | BIOLOGICAL STERILIZATION INDICATOR SYSTEM AND METHOD - A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The BI can further include a frangible container containing a liquid and dimensioned to be positioned in the housing. The reading apparatus can be configured to detect activation of the biological sterilization indicator, for example, by detecting that the second portion is in the second position, and/or by detecting that the liquid from the frangible container is present in a specific chamber of the biological sterilization indicator. The method can include positioning the BI in the well of the reading apparatus and detecting activation, for example, by detecting one or more of the above conditions. | 08-15-2013 |
20130217064 | Integrated cultivation and measurement device for label-free detection and classification of cellular alterations, in particular for generation and characterisation of cell-spheroids, components and uses thereof - The invention relates to an integrated cultivation and measurement device for label-free detection and classification of cellular alterations, in particular for generation and characterisation of cell-spheroids and monitoring the condition of the cell-spheroids in real time, comprising a) a mounting device for a cultivation chamber plate, b) an amplifier board linked with the contacts for the microelectrodes in the mounting device, c) a rotary shaker, on which the amplifier board and the mounting device for the cultivation chamber plate are placed, and d) a control unit, that is linked with the amplifier board and the rotary shaker, wherein the control unit allows recording, analyzing of data and controlling of the movement of the rotary shaker. The cultivation chamber plate has several culture reservoirs, wherein the bottom of each culture reservoir forms a microcavity and each microcavity features microelectrodes on the microcavity walls. The mounting device has contacts for the microelectrodes. The invention advantageously allows the automated generation, cultivation and characterisation of spheroids, as well as the cultivation and characterisation of tissue probes. | 08-22-2013 |
20130224785 | METHOD AND DEVICE FOR DESORPTION IONIZATION - The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method. | 08-29-2013 |
20130224786 | FLOW CYTOMETER APPARATUS AND METHOD - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 08-29-2013 |
20130224787 | FLOW CYTOMETER METHOD AND APPARATUS - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 08-29-2013 |
20130224788 | METHOD FOR DETECTING MICROORGANISMS WITH A SPECIMEN - A process for preparing reagents for a microorganism detection test comprising: a) centrifuging medium containing a microorganism; b) filtrating the supernatant from (a); c) preparing diluted samples of the filtrate from (b); d) treating the diluted samples from (c) with an E/M field; e) detecting signals emitted from (d) using a solenoid; f) selecting samples from (e) whose signal amplitude is ≧1.5 times greater than background noise emitted by water or that present a frequency displacement towards higher values; g) placing the diluted samples from (f) into an enclosures protecting against external electromagnetic fields; h) splitting a diluted sample from (g), volume by volume, into two tubes, T | 08-29-2013 |
20130224789 | METHODS OF MONITORING AND ANALYZING METABOLIC ACTIVITY PROFILES DIAGNOSTIC AND THERAPEUTIC USES OF SAME - A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: | 08-29-2013 |
20130224790 | Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe - The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells. | 08-29-2013 |
20130230882 | CULTURE METHOD RELATED TO DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO BLOOD CELLS - It is an object of the present invention to provide a method for efficient differentiation into blood cells. Specifically, in the present invention, when blood cells are produced from pluripotent stem cells such as ES cells or iPS cells in vitro, the cells are cultured under a low oxygen partial pressure to increase the efficiency of differentiating the pluripotent stem cells into hematopoietic progenitor cells, erythroid progenitor cells, and the like, so as to increase the number of finally obtained, desired blood cells. | 09-05-2013 |
20130230883 | METHODS FOR DETECTION AND CHARACTERIZATION OF ABNORMAL TISSUE AND CELLS USING AN ELECTRICAL SYSTEM - An apparatus for the diagnosis of a biological sample is disclosed. An embodiments of the apparatus includes a probe, a probe head distally connectable to the probe, the probe head further comprising a plurality of electrode elements thereby forming an electrode array where each electrode element is variably actuatable to apply an electrical signal to the biological sample; an RF signal source for applying the electrical signal to the electrode array; an electrode selector adapted and configured to switch the electrical signal from the RF signal source between the plurality of electrode elements; and a detection circuit for analyzing a dielectric property received from the biological sample. Methods and kits for diagnosing a biological sample are also disclosed. | 09-05-2013 |
20130236925 | DETECTION OF RATE CHANGES IN SYSTEMATIC OSCILLATIONS OF METABOLIC PATHWAYS BY MONITORING ISOTOPE RATIOS - The methods described herein are based on the observation that oscillations in breath isotope ratio data can be used for the purpose of identifying an “unhealthy” state in an organism such as a human. Described herein are methods of determining the state of health of an individual, such as the transition from healthy to infected, by identifying changes in oscillation modes in breath isotope ratio data. Changes in the frequency and/or amplitude of the oscillation modes are correlated with the heath of the individual. The methods can advantageously be used to provide information about the health of an individual in shorter periods of time than previous methods. | 09-12-2013 |
20130236926 | Device For Spraying A Reagent For Fast Microbiological Analysis - The device for spraying a reagent onto a support ( | 09-12-2013 |
20130244272 | PROCESS FOR DETERMINING MYCOTOXIN PRODUCTION FROM A SPECIFIC CHEMICAL FINGERPRINT - The present invention relates to a process for determining mycotoxin production in an interior environment which includes a search for a chemical fingerprint comprising at least one target molecule that is a VOC, optionally cyclic, associated with mycotoxin production, preferably selected from the group comprising cububene, cadiene, copaene, ylangene, D germacrene, muurolane, 1,1-dimethylbutylbenzene, 1,1,2-trimethyl-propyl-benzene, 1-hexyltetradecylbenzene, tetratetracontane, 1-ethyldecylbenzene, hydroxytoluene butylate, 1-butyloctylbenzene, 1-propylnonylbenzene, 2-methylisoborneol and at least one sesquiterpene. | 09-19-2013 |
20130244273 | Determination of Decreased Metabolism of Tryptophan in Diagnosis of Autism Spectrum Disorders - Methods for diagnosis of autism spectrum disorders are described. Methods include culturing a cell sample of a test subject with a tryptophan-containing energy source and examining the culture to determine the ability of the cells of the test subject to properly metabolize tryptophan. A determination that a subject does not properly metabolize tryptophan is an indication that the subject may be afflicted with autism. Methods can be utilized as a quick and reliable diagnostic tool for autism spectrum disorders and may provide a unifying model for the genetic heterogeneity of autism spectrum disorders. | 09-19-2013 |
20130252276 | SAMPLE ANALYZER AND COMPUTER PROGRAM PRODUCT - A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed. | 09-26-2013 |
20130260411 | Modular compositing screening protocols - Multiple samples are taken from multiple units of food product to be tested for pathogen or other microbes, with the samples being pooled for composite testing, individual testing being required only in the event that the pool indicates positive. | 10-03-2013 |
20130260412 | SAMPLE PROCESSING APPARATUS, SAMPLE ANALYZER, SAMPLE ANALYZING SYSTEM, SAMPLE PROCESSING SYSTEM AND SAMPLE PROCESSING METHOD - The present invention is a sample processing apparatus. The sample processing apparatus includes: a reader configured to read, from a storage medium attached to a sample container containing a sample or a sample rack supporting the sample container, an analysis value which has been generated by a sample analyzer analyzing the sample for a predetermined analysis item; a sample processing section which comprises an operating mechanism configured to perform an operation for processing the sample, and a controller configured to control the operating mechanism of the sample processing section so as to perform processing on the sample based on the analysis value read by the reader. | 10-03-2013 |
20130260413 | ANALYSIS RESULT PROVIDING SYSTEM, SAMPLE ANALYZING SYSTEM, ANALYSIS RESULT PROVIDING APPARATUS, SAMPLE ANALYSIS RESULT PROVIDING METHOD, AND STORAGE MEDIUM - An analysis result providing system comprising, a sample analyzing section which analyzes a sample collected from a subject, a validation section which validates an analysis result obtained by the sample analyzing section, an e-mail sending section which sends, when an analysis result of the sample collected from the subject has been validated by the validation section, an e-mail for providing the analysis result; and a handheld device which is carried by the subject and which is capable of receiving the e-mail sent by the e-mail sending section and displaying a content of the e-mail. | 10-03-2013 |
20130260414 | SAMPLE ANALYZING SYSTEM, SAMPLE ANALYZER, AND MANAGEMENT METHOD OF SAMPLE ANALYZING SYSTEM - A sample analyzing system comprising: a first sample analyzer including a first measurement unit for measuring a sample and a first control unit for controlling the first measurement unit; and a second sample analyzer including a second measurement unit for measuring the sample and a second control unit for controlling the second measurement unit; wherein the first control unit is configured to transmit an activation signal for activating the second sample analyzer when a predetermined condition is met for the first sample analyzer; and the second control unit is configured to activate the second sample analyzer when the activation signal is received. | 10-03-2013 |
20130260415 | SAMPLE ANALYZER AND METHOD FOR CONTROLLING A SAMPLE ANALYZER - Disclosed is a sample analyzer comprising: a sample measuring section including a detecting section for detecting a component contained in a sample and a flow path for feeding the sample to the detecting section; and a control section. The control section is programmed to automatically control the sample measuring section to flow a sample blank free of particles to the detecting section and detect a component contained in the sample blank to check a background of the detection after the sample measuring section performs washing of the flow path. | 10-03-2013 |
20130260416 | METHOD AND SYSTEM FOR DETECTING MICROCYSTIN FROM REFLECTED LIGHT - The present invention relates to a method of detecting microcystin in water from reflected light, and also includes devices for the measurement, calculation and transmission of data relating to that method. | 10-03-2013 |
20130266980 | SYSTEM, DEVICE, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR IMAGING LARGE AREAS WITH MICROSCOPIC RESOLUTION - Exemplary systems, method and non-transitory computer-accessible medium can be provided for generating an image of at least one tissue that can be subdivided into a plurality of strips. Using such exemplary systems, method and computer-accessible medium, it is possible to scan, using an optical arrangement to generate first information, a first portion of the tissue(s) along a first one of the strips while the tissue(s) can be mechanically moved in a first direction. Move the one tissue(s), by a distance equal to or less than a width of the first portion, in a second direction approximately perpendicular to the first direction. Use the optical arrangement to generate second information, a second portion of the tissue(s) along a second one of the strips while the tissue(s) can be mechanically moved in a third direction, which can be approximately opposite to the first direction. Then the image can be generated based on the first information and the second information. | 10-10-2013 |
20130273595 | METHOD FOR DETERMINING AGE OF GINSENG ROOTS USING CHROMATOGRAMPHY-MASS SPECTROSCOPY - Disclosed is a method for determining the age of ginseng roots using chromatography-mass spectroscopy. It comprises: extracting a metabolome from a ginseng sample; subjecting the metabolome to liquid chromatography-mass spectroscopy (LC/MS) or gas chromatography-mass spectroscopy (GC/MS) to afford an analysis result; converting the LC/MS or GC/MS analysis result to statistically accessible data; and performing a statistical analysis of the data to determine the age of ginseng sample. Based on the metabolite fingerprinting of metabolomics, the method can determine the exact age of ginseng roots from a very small amount of roots within a short time in a non-destructive manner with minimal damage to the roots. | 10-17-2013 |
20130273596 | NEURAL CREST ENHANCERS AND METHODS FOR USE - DNA enhancer sequences are provided for use in constructs to identify early stage embryonic cells. The enhancer sequences can be used in parallel with short-hairpin RNA in a vector construct for endogenously regulated gene knockdowns. The disclosed enhancer sequences can be used to isolate a selected population of early stage embryonic cells. | 10-17-2013 |
20130273597 | PROCUREMENT EXTRACTION BAG - There is disclosed a method of procuring allograft tissue. In an embodiment, the method includes inserting an allograft through an opening into a procurement extraction container, sealing the opening, adding extraction fluid through a second opening, agitating the fluid, collecting the fluid for detection of contamination, and sealing the second opening. There is disclosed a procurement extraction container. In one embodiment, the container includes a wall defining an interior to receive the allograft, an opening into the interior, sized to receive the allograft, a closure device for the opening, the closure device providing a hermetic seal, a second opening providing a second passageway into the interior, the second opening having a connector interface and a second closure device providing a hermetic seal so as to provide, with the first closure and the at least one wall, a sterile barrier. Other embodiments are also disclosed. | 10-17-2013 |
20130280756 | CULTURE MEDIUM FOR MICROORGANISMS INCLUDING PARA-AMINOBENZOIC ACID AS A SELECTIVE AGENT - The field of the invention is the analysis of target microorganisms in a complex sample. The present invention more particularly relates to a culture medium for the detection of at least one target microorganism including: at least one natural or synthetic fermentation or enzymatic activity substrate, and at least one selective agent, which inhibits non-target microorganisms, constituted by para-amino benzoic acid, one of its derivatives or one of their salts, at a concentration of between 0.05 and 1 g/L. | 10-24-2013 |
20130288294 | DETECTION OF MICROORGANISMS INVOLVED IN METABOLISM OF ORGANIC ENVIRONMENTAL POLLUTANTS - A method and point of use kit to determine under field conditions the presence and/or amount of a selected | 10-31-2013 |
20130295602 | METHODS, SYSTEMS AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICROFLUIDICS - Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing. Reaction products may be harvested and/or further analyzed in some cases. | 11-07-2013 |
20130302850 | METHOD AND EQUIPMENT FOR THE AUTOMATED TESTING OF MICROBIOLOGICAL SAMPLES - By using the method and equipment according to this invention it is possible to analyse rapidly a large number of microbiological culture samples, or alternatively of liquid phase samples, based on the gases or gaseous compounds released by them. This invention exploits generally a sample line, along which the samples move, and it can be used for the microbial control tasks in hospitals, industry, hygiene and environmental fields. In this system gas is led into the culture vessels during the growth of the microbe, and gases released by the culture or liquids derived from them are collected into the chambers, capsules or equivalents. | 11-14-2013 |
20130309712 | MASS SPECTROMETRIC IDENTIFICATION OF HYPHAL FUNGI - A method is provided for identifying a hyphal fungus in a sample by similarity comparisons between a mass spectrum of the fungus and reference spectra. The method includes growing fresh hyphae without any adhering contact to surfaces as to form a mycelium with undifferentiated hyphae cells. A sample is prepared from the hyphae cells, and a mass spectrum is acquired of the hyphae cell sample. The mass spectrum is matched with at least one reference spectrum. | 11-21-2013 |
20130309713 | PATHOGEN DETECTION SYSTEMS AND METHODS - Pathogen and chemical detection systems for use with a patient support apparatus and related methods are disclosed. A fluid or biologic sample from the vicinity of a person supported by a person support apparatus is acquired and transmitted to a pathogen detection sensor. A graphical caregiver interface is supplied output from the pathogen detection sensor and detects the presence of a chemical. The graphical caregiver interface communicates with an electronic medical records database, and alarm and a nurse call system. | 11-21-2013 |
20130309714 | Methods for Inactiviation And Extraction of Acid-Fast Bacteria for Characterization And/Or Identification Using Mass Spectrometry - The present invention is directed to a method for inactivation and/or extraction of acid-fast bacteria (e.g., | 11-21-2013 |
20130316393 | MICROBIAL DETECTION ARTICLE HAVING A WATER-ABSORBENT FILTER ASSEMBLY - A microbial detection article and methods of using the same, the article comprising: a base member comprising a self-supporting water impervious substrate with first and second generally opposed major surfaces; a filter assembly defining a filter assembly aperture therein, and having a composite filter body mounted across the filter assembly aperture; wherein the composite filter body comprises: a microporous membrane, and a water-absorbent layer in fluid communication with the microporous membrane; and a cover sheet. | 11-28-2013 |
20130316394 | VIABILITY STAINING METHOD - The invention relates to a method of detecting viable cells in a cell sample, using a membrane permeable fluorescent label that permeates both viable and non-viable cells and a membrane impermeant quencher that selectively permeates non-viable cells. | 11-28-2013 |
20130316395 | OPTICAL PARTICLE DETECTING DEVICE AND PARTICLE DETECTING METHOD - An optical particle detecting device includes a light source that emits light, an optical fiber that carries the emitted light, an emission-side condensing lens that condenses the light emitted from an end portion of the optical fiber, and a jet mechanism that causes an airstream including a particle to cut across the beam condensed by the emission-side condensing lens. | 11-28-2013 |
20130323780 | PROMOTERS AND TERMINATORS FOR USE IN EUKARYOTIC CELLS - The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the heterologous gene; and methods for identifying promoters. | 12-05-2013 |
20130323781 | DEVICE FOR DETECTING A FUNGAL CONTAMINATION - The present invention relates to a device for detecting a fungal contamination in an internal environment, to the use thereof and also to a method for detecting a fungal contamination in an internal environment using such a device. | 12-05-2013 |
20130323782 | METHOD OF GENERATING INDUCED PLURIPOTENT STEM CELLS AND DIFFERENTIATED CELLS - Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells. | 12-05-2013 |
20130337492 | METHOD AND SYSTEM FOR REAL-TIME, NON-INVASIVE MONITORING OF A BIOLOGICAL MATERIAL IN A SEALED CONTAINER - A biological material such as platelets is sealed inside a container with a dead space to accommodate a metabolic gas. The concentration of the gas in the dead space is monitored while the container remains sealed. In some embodiments, the container is permeable to the gas. In other embodiments, the biological material is the only growth medium in the container. The disposal of the biological material is in accordance with the monitored gas concentration. Preferably, the gas concentration is measured spectroscopically. A container for a biological material includes a main body that retains the biological material but that is permeable to a gas and a reservoir in fluid communication with the main body that is transparent to an optical wavelength that is absorbed by the gas. | 12-19-2013 |
20130337493 | QUALITY CONTRL DEVICES AND METHODS FOR RADIOPHARMACEUTICALS - A quality control (“QC”) system for PET or SPECT radiopharmaceuticals is disclosed that contains a disposable, no-leakage, self-contained QC cassette, which interfaces with the QC system. The QC system may include a shield that substantially surrounds the cassette such that the area and the cassette are both shielded. The QC cassette may contain shielding also. The QC cassette contains components for conducting one or more QC tests. These components include sensor and devices for performing various QC tests on radiopharmaceuticals. The QC system may contain a number of sub-systems and devices for supporting the QC tests. The QC system may produce a QC report containing the test results. | 12-19-2013 |
20130337494 | FLUORESCENT CYTOTOXIC COMPOUNDS SPECIFIC FOR THE CELLULAR POLYAMINE TRANSPORT SYSTEM - Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these compounds (3 and 4) had improved fluorescence properties over previously known anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy and fluorescence methods. These cytotoxic fluorescent agents may find use as molecular probes which traffic into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: λ405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are considered non-toxic to human cells (versus ultraviolet mediated excitations, λ<400 nm) and visible light lasers are less costly to purchase and operate than UV laser sources. | 12-19-2013 |
20130337495 | HIGH SPEED SPOILAGE DETECTION USING AN ELECTROMAGNETIC SIGNAL - The present disclosure provides a system for inspecting cases of packages having a substance subject to spoilage. An electromagnetic signal (e.g., a terahertz frequency signal) is directed to each package in a case, and an attenuated signal is received and sampled to generate a set of data points corresponding to each package. A peak within each set of data points is detected, and the data points are shifted with respect to time to align the detected peaks with a predetermined time. The sets of shifted data points are compared to a mathematical model to determine whether the substance in the package is spoiled, and a labeling system marks cases containing spoiled substance. | 12-19-2013 |
20130337496 | Method for Detecting a Plasmodium Infection - The invention relates to a method for detecting a | 12-19-2013 |
20130337497 | MAGNETIC FLOW CYTOMETRY FOR HIGH SAMPLE THROUGHPUT - In a measuring device, a production thereof, and a use thereof for magnetic flow cytometry, a microfluidic channel is disposed along an enrichment route such that a magnetically marked cell sample flowing through the microfluidic channel is aligned to magnetic guide strips, enriched by the magnetic field of a magnet at the floor of the channel, and guided past a sensor. The enrichment route is thereby implemented with the microfluidic channel on the packaging of the semiconductor chip carrying the sensor. This construction ensures a long enrichment route for high throughput of large sample volumes. | 12-19-2013 |
20130337498 | MICROORGANISM DETECTION SENSOR AND METHOD OF MANUFACTURING THE SAME - The present invention provides a sensor including a detection unit having a detection electrode and a polymer layer that is disposed on the detection electrode and includes a mold having a three-dimensional structure complementary to a steric structure of a microorganism to be detected. The sensor detects the microorganism based on a state of capturing the microorganism in the mold. The polymer layer is formed by a manufacturing method including: a polymerization step of polymerizing a monomer in the presence of the microorganism to be detected, to form the polymer layer having captured the microorganism on the detection electrode; a destruction step of partially destroying the microorganism captured in the polymer layer; and a peroxidation step of peroxidizing the polymer layer to release the microorganism from the polymer layer. | 12-19-2013 |
20130344532 | Method For Observing A Sample - A method for observing a sample is provided. The method includes the steps of: a) providing a volume (G, V) of a substantially transparent medium having a first refractive index (n | 12-26-2013 |
20130344533 | METHODS AND DEVICES FOR HANDLING BIOFOULING - Provided is a biosensor including a scaffold and a dye complex, the dye complex including a clay material associated with a dye material, where the dye complex is at least partially embedded in the scaffold. Also provided is a process for preparing the biosensor, an apparatus including the biosensor and methods for detecting viable microorganisms in an aqueous fluid test sample making use of the biosensor, for predicting biofouling in a fluid flowing system and for determining a concentration of disinfectant required to disinfect an aqueous fluid. | 12-26-2013 |
20140004559 | SYSTEMS AND METHODS FOR INDIVIDUALLY TRAPPING PARTICLES FROM AIR AND MEASURING THE OPTICAL SPECTRA OR OTHER PROPERTIES OF INDIVIDUAL TRAPPED PARTICLES | 01-02-2014 |
20140004560 | RHIZOPUS ORYZAE STRAIN, MUTAGENESIS AND SCREENING METHODS THEREOF, AND METHODS OF FERMENTING TO PRODUCE FUMARIC ACID | 01-02-2014 |
20140017722 | HEMATOPOIETIC STEM CELL IDENTIFICATION PROBE - The present invention provides a hematopoietic stem cell identification probe. A hematopoietic stem cell analysis probe containing, as an active ingredient, one or more compounds represented by the general formula (1) has been developed: | 01-16-2014 |
20140017723 | APPARATUS FOR MEASURING FLOATING MICROORGANISMS IN A GAS PHASE IN REAL TIME USING A SYSTEM FOR DISSOLVING MICROORGANISMS AND ATP ILLUMINATION, AND METHOD FOR DETECTING SAME - The present invention relates to an apparatus for measuring floating microorganisms in a gas phase in real time using a system for dissolving microorganisms and adenosine triphosphate (ATP) illumination, and to a method for detecting same. The measuring apparatus includes a particle classifying apparatus for collecting floating microorganisms and being coated by an ATP reaction illuminating agent; a system for dissolving microorganisms for dissolving the microorganisms and extracting ATP; and a light receiving device for detecting light generated from the reaction of the extracted ATP by the system and the ATP reaction illuminating agent coated on the particle classifying apparatus. According to the detection method using ATP organism illumination, the floating microorganisms in the gas phase can be readily detected and the detection can be automatically conducted in real time without manual labor. | 01-16-2014 |
20140024072 | SAMPLE ANALYZER, SAMPLE INFORMATION PROCESSING APPARATUS, AND SAMPLE ANALYSIS METHOD - A sample analyzer includes: a first measurement part which performs measurement on a sample for a first measurement item; a second measurement part which performs a measurement on the sample for a second measurement item; an output section; and a controller configured to control the output section to output, when a time difference between a measurement on a sample performed by the first measurement part and a measurement on the sample performed by the second measurement part exceeds a predetermined time period, information based on an excess of the time difference. | 01-23-2014 |
20140038229 | SELECTION OF IMPROVED MICROBIAL STRAINS FOR PRODUCTION OF SUCCINIC ACID FROM GLYCEROL - Provided are methods for generating a microorganism with improved ability to convert glycerol to succinic acid. These methods comprise combining a microorganism with ability to convert glycerol to succinic acid and a medium containing glycerol to produce a fermentation mixture; allowing fermentation to occur such that succinic acid is produced; and assaying for an indication of glycerol metabolism. These latter two steps may be repeated as necessary. Also provided are microorganisms generated in this manner, particularly bacteria deposited at the NCIMB on 13 | 02-06-2014 |
20140045209 | Structures for Enhancement of Local Electric Field, Light Absorption, Light Radiation, Material Detection and Methods for Making and Using of the Same - Microstructures and nanostructures ( | 02-13-2014 |
20140045210 | MICROPLATE READER WITH LID LIFTER FOR MICROPLATES - Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing. | 02-13-2014 |
20140051113 | APPARATUS AND METHODS FOR MICROBIOLOGICAL ANALYSIS - Methods and systems for identification of microorganisms either after isolation from a culture or directly from a sample. The methods and systems are configured to identify microorganisms based on the characterization of proteins of the microorganisms via high-resolution/mass accuracy single-stage (MS) or multi-stage (MS | 02-20-2014 |
20140051114 | CELL ANALYZER AND CELL ANALYZING METHOD - Provided are a cell analyzer, and a cell analysis method. A cell analyzer | 02-20-2014 |
20140051115 | METHOD AND APPARATUS FOR COLLECTING REPRESENTATIVE MICROBIOLOGICAL WATER AND LIQUID SAMPLES - With a method and equipment according to this invention the best possible growth start of hygiene indicators and other bacteria and other microbes in water samples is ensured in microbe cultivations for example on Colilert™ media using both static cultivations and bubbled cultures such as in a PMEU (Portable Microbe Enrichment Unit) type cultivation. The objective is the best possible microbiological detection value of a water sample or process sample regardless of whether the said cultivation is implemented without bubbling or other mixing or with it. The equipment and method according to the invention applies to and can be connected with automatic or manual sampling. | 02-20-2014 |
20140051116 | METHOD FOR CHARACTERISING THE ORIGIN AND/OR CONDITION OF DISEASED OR HEALTHY CELLS AND USES THEREOF IN BIOLOGY - The invention relates to a method for characterising the origin and/or condition of diseased or healthy cells, characterised in that it includes the measurement of isotopic variations in a natural abundance of elements of cells, the contents of which are modified in a situation of disease, using an isotope-ratio mass spectrometer (abbreviated as IRMS), advantageously using an elemental analyser coupled with an isotope-ratio mass spectrometer (abbreviated as EA-IRMS). | 02-20-2014 |
20140051117 | MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA - The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from bloodstream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles. The method is based on the use of relatively strong tensides to destroy the blood particles by dissolving the weak cell membranes and most of the internal structures of the blood particles; in spite of the fact that tensides are regarded as strong ionization inhibitors in MALDI and other ionization processes required for mass spectrometric measurements. This method allows unknown pathogens to be obtained in their pure form by centrifuging or filtration and to be identified on the taxonomic level of species or subspecies. Problems with DNA from high levels of leukocytes can be resolved by special measures. After sufficient cultivation, the identification in a mass spectrometric laboratory takes only half an hour. | 02-20-2014 |
20140057315 | ANTIGEN PRESENTING CELL ASSAY - Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells. | 02-27-2014 |
20140073000 | METHODS AND MEANS FOR MANIPULATING PARTICLES - The present invention is concerned with a system for sorting target particles from a flow of particles. The system has a microscope, a light source, a CCD camera, microfluidic chip device with microfluidic channels, a detection apparatus for detecting the target particles with predefined specific features, a response generating apparatus for generating a signal in response to the detection of the target particles, and an optical tweezing system for controlling movement of optical traps, the optical tweezing system is operably linked to the response signal. | 03-13-2014 |
20140073001 | Method for Detection or Identification of Bacteria or Bacterial Spores - A method and apparatus for detecting bacteria and bacterial spores are disclosed in which a sample is assessed for the presence of bacteria and/or bacterial spores by reference to horizontally polarized fluorescent light. | 03-13-2014 |
20140073002 | METHOD FOR DETERMINING DIFFERENTIATION LEVEL OF PLURIPOTENT STEM CELLS - The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication. | 03-13-2014 |
20140080172 | Systems and Methods for Monitoring Chemical Processes - Disclosed are systems and methods for monitoring chemical reaction processes in or near real-time. One method may include containing a fluid within a flow path, the fluid having a chemical reaction occurring therein, optically interacting at least one integrated computational element with the fluid, thereby generating optically interacted light, and producing an output signal based on the optically interacted light that corresponds to a characteristic of the chemical reaction. | 03-20-2014 |
20140080173 | PRODUCTION OF AN ASPERGILLUS CONTAMINATION IMPRINT BASED ON DETECTION OF MVOC - This invention proposes a method comprising the steps of: | 03-20-2014 |
20140087417 | Personal Care Products with Visual Indicator of Vaginitis - There is provided a personal care product having a body side liner, a baffle and an indicator strip with two ends. The indicator has an amine sensitive dye near at least one end. The indicator extends from the target area just below the liner to just above the baffle such that the dye deposit is visible to an unaided eye. The dye changes color in the presence of amines which are characteristic of infection, thus alerting the user to the possibility of infection. Such an indicator placed in a feminine hygiene pad, for example, may be useful in the diagnosis of vaginitis. | 03-27-2014 |
20140087418 | ORGANIC-INORGANIC NANOFLOWERS, THEIR SYNTHESIS AND USE - Organic-inorganic nanoflowers, methods of synthesis, and uses of the nanoflowers are described. It has been found that organic-inorganic nanoflowers can be grown in the presence of a solid substrate containing copper without the requirement for added copper ion. The method includes exposing bacteria to a solid substrate containing copper in the presence of an aqueous solution that contains phosphate ions. The aqueous solution can additionally contain chloride ions, similar to that of a phosphate-buffered saline composition. The solid substrate can be an alloy of copper and tin, and the substrate can have phosphorus incorporated into it. | 03-27-2014 |
20140099663 | GMR SENSOR - A system includes a first sensor, a field source, and a processor. The first sensor includes a surface and has an electrical resistance determined by a magnetic field at the surface. The field source is configured to provide a biasing magnetic field to the surface. The biasing magnetic field is aligned parallel to the surface and aligned perpendicular relative to the surface. The magnetic field has a frequency. The processor is coupled to the sensor and is configured to determine a parameter based on a measure of a change in the resistance. The change in the resistance corresponds to the resistance at a time before onset of a magnetic field perturbance at the surface and a time after the onset of the magnetic field perturbance at the surface. | 04-10-2014 |
20140106397 | SYSTEMS AND METHODS FOR DETECTING AN ANALYTE OF INTEREST IN A SAMPLE USING FILTERS AND MICROSTRUCTURED SURFACES - Systems and methods for detecting an analyte of interest in a sample. The system can include a first container comprising a filter portion. The filter portion can include a filter comprising a filtrand of the sample on a first side of the filter. The system can further include a second container comprising the filter portion coupled to a detection portion comprising a microstructured surface. The method can include providing the first container, coupling the filter portion to the detection portion to form the second container where the first side of the filter faces the microstructured surface, and centrifuging the second container toward the microstructured surface. The method can further include inverting the second container after centrifuging to decant the supernatant from the detection portion, such that a concentrate comprising a sediment of the sample is retained in the microstructured surface, which can be interrogated for an analyte of interest. | 04-17-2014 |
20140113325 | USE OF FLUORESCENT SACCHARIDE-BASED DERIVATIVE - The disclosure provides a use of a fluorescent saccharide-based derivative in cell detection. The fluorescent saccharide-based derivative is obtained from a reactive material through an imine formation reaction, and the reactive material is selected from a composition (A) or a composition (B). The composition (A) includes a reducing sugar compound and an amino group-containing compound having at least one primary amino group. The composition (B) includes an amino sugar compound and a carbonyl group-containing compound, and the amino sugar compound contains at least one primary amino group. | 04-24-2014 |
20140113326 | KIT FOR DETECTING BIOFILMS - The invention relates to a kit for detecting biofilms, which is in particular compatible with the agri-food industry and comprises a biofilm staining solution containing a stain in solution in a dilution phase compatible with the agri-food industry, wherein said stain is Coomassie blue, and a cleaning solution comprising said dilution phase. | 04-24-2014 |
20140120574 | FLUORESCENT NITRIC OXIDE PROBES AND ASSOCIATED METHODS - Nitric oxide probes comprising a compound represented by Formula I are provided. Methods of using this nitric oxide probes to detect nitric oxide are also provided. | 05-01-2014 |
20140127742 | METHODS AND SYSTEMS FOR MONITORING LIQUIDS - Technologies are generally disclosed for systems and methods for monitoring a liquid. An illustrative method may include disposing one or more sensors in the liquid, sensing one or more properties exhibited by the liquid using the one or more sensors, producing sensed data from the properties by the one or more sensors, encoding the sensed data into an acoustic signal by the one or more sensors, transmitting the acoustic signal through the liquid by the one or more sensors and receiving the acoustic signal by one or more sound receiving devices. | 05-08-2014 |
20140127743 | METHODS FOR PRODUCING RECOMBINANT PROTEINS - Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins. | 05-08-2014 |
20140134670 | IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT USING TAXONOMIC HIERARCHICAL CLASSIFICATION - A method for identification and/or characterization of a microbial agent present in a sample includes a step of analytical test data (e.g., obtaining intrinsic fluorescence values over a range of emission wavelengths) from the microbial agent. The analytical test data is transformed thereby minimizing strain to strain variations within an organism group. With the aid of a programmed computer, a multi-level classification algorithm coded as a set of processing instructions operates on the transformed analytic test data. The multiple levels correspond to different levels in a taxonomic hierarchy for microbial agents suspected of being in the sample | 05-15-2014 |
20140141466 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 05-22-2014 |
20140147881 | MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR IDENTIFICATION - The present invention provides a method and apparatus to identify at least one component from a plurality of components in a fluid mixture, the apparatus including a first input channel into which a first flow containing a plurality of components is introduced; a plurality of buffer input channels, into which additional flows of buffer solution are introduced, disposed on either side of the first input channel; wherein the first flow and the additional flows have a flow direction along a length of the apparatus; a detector apparatus which detects and identifies selected components of the plurality of components; a laser which emits a laser beam which damages or kills selected components of the plurality of components; and at least one channel disposed at the another end of the apparatus which is adapted to receive the first flow and the additional flows after operation of the laser on the selected components. | 05-29-2014 |
20140147882 | METHOD AND DEVICE FOR DETECTION AND QUANTIFICATION OF THERMODURIC MICROORGANISMS IN A PRODUCT - Method of detecting the presence of thermoduric microorganisms in a product that includes the steps of (i) placing an aliquot A of a product into a vessel 10 equipped with a probe 30 sensitive to a thermoduric microorganism metabolite, (ii) pasteurizing the aliquot A within the vessel 10, (iii) incubating the pasteurized aliquot A within the vessel 10 for an incubation period, and (iv) periodically interrogating the probe 30 during the incubation period. | 05-29-2014 |
20140162309 | Arsenical Fluorescent Agents and Assays - The invention provides methods and compositions for labeling dithiol-containing analytes, including a substituted, optionally hydro-, optionally hetero-, monoarsenical anthracene compound comprising a 4′ rotation blocking group and a 5′ arsenic, and that exhibits a detectable increase or shift in fluorescence when the arsenic reacts with two thiols of a rotation-blocking binding target molecule. | 06-12-2014 |
20140170698 | Microbead Kit and Method for Quantitative Calibration and Performance Monitoring of a Fluorescence Instrument - Fluorescently labeled microsphere calibration and quality control particles for use in establishing standardized fluorescence detector setup, monitoring daily QC of flow cytometers and quantitative calibration of the fluorescence detectors in traceable units of measure (molecules equivalent soluble fluorescence; MESF). | 06-19-2014 |
20140170699 | TEST FOR DETECTING SPOILAGE IN A FLEXIBLE PACKET - An apparatus for detecting spoilage of the contents of a packet is disclosed. The apparatus includes a pair of holding panels ( | 06-19-2014 |
20140178923 | TRICLOSAN DERIVATIVES AND USES THEREOF - A selective agent comprising a triclosan derivative for use in selective inhibition of non-target cells in a mixed population of target and non-target cells. Preferably the triclosan derivative is a glycoside derivative, more preferably a pyranoside derivative. Suitably a selective medium comprising said selective agent and methods of culturing cells using the selective agent are provided. | 06-26-2014 |
20140178924 | IDENTIFICATION OF MYCOPLASM CONTAMINATION IN BIOTECHNOLOGY PRODUCTION USING RAMAN SPECTROSCOPY - contamination of a known cell line is detected by collecting a Raman spectrum of a targeted volume within a sample, the targeted volume containing a known cell line of interest, obtaining a reference spectrum uniquely associated with the known cell line where the obtained reference spectrum is known to be free of mycoplasma and comparing, using a processing device, the reference spectrum to the collected spectrum. | 06-26-2014 |
20140186878 | FLUOROGENIC OR FLUOROPHORIC COMPOUNDS AND USES THEREOF - Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions. | 07-03-2014 |
20140186879 | Methods for Separation, Characterization and/or Identification of Microorganisms using Spectroscopy - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements. | 07-03-2014 |
20140193852 | ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE - Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module. | 07-10-2014 |
20140199724 | Method and Culture Medium for Enhanced Detection of Mycobacterium - The present invention relates to an improved culture medium and method for the enhanced growth and detection of | 07-17-2014 |
20140212916 | RAPID TEST FOR DETECTION OF INFECTION AND THERAPEUTIC RESPONSE - The present invention is directed to the use of isotopically labeled citrulline for gnosing the presence or absence of a bacterial infection in the lungs of a patient. | 07-31-2014 |
20140212917 | COMPENSATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MICRO-ENTITIES - Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities. | 07-31-2014 |
20140220617 | DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE - A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics. | 08-07-2014 |
20140220618 | MEASURING EMBRYO DEVELOPMENT AND IMPLANTATION POTENTIAL WITH TIMING AND FIRST CYTOKINESIS PHENOTYPE PARAMETERS - Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans. | 08-07-2014 |
20140220619 | ABNORMAL SYNGAMY PHENOTYPES OBSERVED WITH TIME LAPSE IMAGING FOR EARLY IDENTIFICATION OF EMBRYOS WITH LOWER DEVELOPMENT POTENTIAL - Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans. | 08-07-2014 |
20140220620 | MULTI-CHANNEL SYSTEM AND METHODS FOR SORTING PARTICLES - A multi-channel system and methods for sorting particles according to one or more characteristics of the particles. The system includes multiple flow cytometry units, each unit can have a nozzle for producing a fluid stream containing a desired population of particles in a mixture of particles. Each of the units may be operable to sort said desired population of particles by interrogating the fluid stream with a beam of electromagnetic radiation and classifying particles based on one or more characteristics of the particles. The system also includes a common fluid delivery system for delivering sheath fluid to each flow cytometer unit for producing respective fluid streams. | 08-07-2014 |
20140220621 | CHARACTERIZATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MICRO-ENTITIES - Apparatus and methods for detecting and characterizing motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter related to a system clock. The motion-related error may be characterized by correlating measurements of micro-entities moving within a fluid stream. | 08-07-2014 |
20140234893 | HETEROLOGOUS INTRON WITHIN AN IMMUNOGLOBULIN DOMAIN - The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel intron sequences as heterologous introns. | 08-21-2014 |
20140255980 | MICROORGANISM DETECTING APPARATUS AND MICROORGANISM DETECTING METHOD - A microorganism detecting device includes a light source that illuminates a particle with an excitation beam, a fluorescence detector that detects fluorescence produced by the particle, an evaluating portion that evaluates that the particle is a microorganism if there is a plurality of peaks in the fluorescence spectrum, and evaluates that the particle is a non-microorganism if there is a single peak in the fluorescence spectrum. | 09-11-2014 |
20140255981 | METHOD OF CANCER DIAGNOSIS USING THE ANALYSIS OF ISOTOPES - Disclosed is a method of diagnosing cancer on the basis of the quantitative analysis of blood or tissue isotopes, for example, such as | 09-11-2014 |
20140255982 | METHOD OF CANCER DIAGNOSIS USING THE ANALYSIS OF ISOTOPES - Disclosed is a method of diagnosing cancer on the basis of the quantitative analysis of blood or tissue isotopes, for example, such as | 09-11-2014 |
20140255983 | METHOD OF CANCER DIAGNOSIS USING THE ANALYSIS OF ISOTOPES - Disclosed is a method of diagnosing cancer on the basis of the quantitative analysis of blood or tissue isotopes, for example, such as | 09-11-2014 |
20140295484 | MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION AND DISEASE ACTIVITY - The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides the necessary information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through one or more metabolic pathways of interest. By this method, a comparison between subjects and control subjects reveals the effects of the chemical entity or entities on the biomarkers. This, in turn, allows for the identification of potential therapeutic uses or toxicities of the compound. Combinations of compounds can also be systematically evaluated for complementary, synergistic, or antagonistic actions on the metabolic pathways of interest, using the methods of the present invention as a strategy for identifying and confirming novel therapeutic or toxic combinations of compounds. | 10-02-2014 |
20140295485 | MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION AND DISEASE ACTIVITY - The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides the necessary information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through one or more metabolic pathways of interest. By this method, a comparison between subjects and control subjects reveals the effects of the chemical entity or entities on the biomarkers. This, in turn, allows for the identification of potential therapeutic uses or toxicities of the compound. Combinations of compounds can also be systematically evaluated for complementary, synergistic, or antagonistic actions on the metabolic pathways of interest, using the methods of the present invention as a strategy for identifying and confirming novel therapeutic or toxic combinations of compounds. | 10-02-2014 |
20140295486 | BIOLOGICAL DETECTOR AND METHOD - A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid. | 10-02-2014 |
20140295487 | BLOOD CELL ANALYZER AND BLOOD CELL ANALYZING METHOD - A blood cell analyzer comprises a flow cell configured to flow a measurement specimen containing blood cells, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, a first light receiving portion configured to receive first scattered light obtained by irradiating the blood cells passing through the flow cell with light from the first light source, a second light receiving portion configured to receive second scattered light obtained by irradiating the blood cells passing through the flow cell with light from the second light source, and a control section configured to discriminate at least red blood cells from the blood cells contained in the measurement specimen based on detection signals output from the first light receiving portion and the second light receiving portion, respectively. | 10-02-2014 |
20140295488 | BLOOD CELL ANALYZER AND BLOOD CELL ANALYZING METHOD - A blood cell analyzer comprising a flow cell configured to flow a measurement specimen containing blood cells, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, a first light receiving portion configured to receive first scattered light generated by irradiating the blood cells in the measurement specimen with light from the first light source, a second light receiving portion configured to receive second scattered light generated by irradiating the blood cells in the measurement specimen with light from the second light source, and a control section configured to classify at least white blood cells from the blood cells contained in the measurement specimen, based on a detection signal output from the first light receiving portion and a detection signal output from the second light receiving portion. | 10-02-2014 |
20140295489 | ORGANIC COMPOUNDS - The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. | 10-02-2014 |
20140302550 | CULTURE MEDIUM KIT AND METHOD FOR DETECTION OF MICROORGANISMS - The present invention discloses culture medium unit doses for cultivating microorganisms comprising at least two compositions, each composition packaged in a composition unit dose of a predetermined amount, the composition unit doses being used for combining one of each composition unit dose forming the culture medium unit dose. The composition unit doses being packaged separately and individually until a time the culture medium unit dose is to be prepared for use for cultivation of microorganisms, wherein the time one of each composition unit dose are combined thereby forming the culture medium unit dose. The invention also discloses a method of manufacturing the composition unit doses, and a kit for cultivating microorganisms, the kit comprising a combination of the composition unit doses. | 10-09-2014 |
20140308697 | METHODS AND APPARATUSES FOR IDENTIFYING RED BLOOD CELLS INFECTED BY PLASMODIUM - The present disclosure relates to the field of medical technology, which provides methods and apparatuses for identifying red blood cells infected by plasmodium. The methods may include: obtaining a forward-scattered light signal, a side-scattered light signal and an optional fluorescence signal from cells in a blood sample; obtaining a first two-dimensional scattergram according to the forward-scattered light signal and the side-scattered light signal, or obtaining a three-dimensional scattergram according to the forward-scattered light signal, the side-scattered light signal and the fluorescence signal; and identifying cells located in a predetermined area of the first two-dimensional scattergram or the three-dimensional scattergram as the red blood cells infected by plasmodium. The apparatuses perform the methods. The methods and apparatuses can have better identification accuracy. | 10-16-2014 |
20140315241 | MICROSENSOR - The present invention relates to a miniature device for detecting, identifying and/or quantifying microorganisms in a sample. The device comprises a surface for contact with a sample to be analysed, said surface defining a pore and said pore comprising means for reporting the presence of a microorganism. The reporting means may comprise a solid or semi-solid substrate, a metabolic indicator; and a media and/or nutrients that support or encourage microbial growth. | 10-23-2014 |
20140322746 | Multi-Way Sorter System and Method - Provided herein are improved multi-way cell sorter systems and methods. For example, provided are systems and methods for the collection of cells that are sorted in multiple directions. The systems and methods allow for the construction of a multi-way sorter (e.g., a ten-way sorter in the space that currently only allows four-way sorting). In addition the device may actively sense the arrival of drops (with cells of interest) at a sample tube, and trigger an alarm when the drops' arrivals deviate from an expected pattern. | 10-30-2014 |
20140322747 | OBJECT SELECTING DEVICE AND OBJECT SELECTING METHOD - An object selecting device includes a container configured to store liquid, a plate configured to support a selection object by being immersed into the liquid stored in the container, and a holder configured to hold the plate in a state where a bottom surface of the plate and an inner bottom part of the container are separated. The plate includes a through hole at a support position. The through hole includes a tapered portion configured to allow the selection object to precipitate along a direction of gravity and support the selection object in contact with the inner wall surface of the through hole. An opening area at the upper end of the tapered portion is larger than that at the lower end of the tapered portion. Only the selection object can be supported out of the collection of objects having different shapes. | 10-30-2014 |
20140322748 | System and Method to Improve Yield of Sorted Particles - Provided herein are systems and methods for improving yield of sorted particles. In one embodiment, for example, there is provided a system including: (a) a flow cytometer to analyze a sample, wherein the flow cytometer provides a parameter plot based on the analysis of the sample; (b) a user-interface, wherein a user can define a coincidence acceptance gate in the parameter plot, and wherein the coincidence acceptance gate identities a non-target particle population in the sample that may be accepted with a target particle in a subsequent sort analysis; and (c) a sort analysis system to sort particles within the sample, while accepting particles defined by coincidence acceptance gate. | 10-30-2014 |
20140329271 | SCREENING FOR NITROGEN FIXATION - An essentially glutamine-free medium comprising a whole-cell glutamine biosensor, comprising a glutamine auxotrophic | 11-06-2014 |
20140329272 | Metal-Based Covalent Viability Reagent for Single Cell Analysis - The present invention provides a robust viability stain for methods utilizing elemental analysis. A population of cells is contacted with an effective dose of a non-chelated biomacromolecule-reactive metal derivative, which selectively crosses the plasma membrane of non-viable cells, and which covalently modifies a biological macromolecule within the cell, for a period of time sufficient to permit entry into non-viable cells. The population of cells is then washed free of unbound viability reagent; and the presence of the metal within the cells is detected, wherein non-viable cells are selectively labeled with the viability reagent. | 11-06-2014 |
20140329273 | APPARATUS FOR COLLECTING DONATED STOOL - Disclosed are an apparatus for the collection of donated stool, a collection chamber for depositing (or collecting), processing and harvesting stool from a donor and a process for the preparation of a composition comprising donated stool and a pharmaceutically acceptable carrier. | 11-06-2014 |
20140329274 | METABOLIC FLUX MEASUREMENT, IMAGING AND MICROSCOPY - Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample. | 11-06-2014 |
20140335556 | MASS SPECTROMETRIC DETERMINATION OF MICROBIAL RESISTANCES - The invention relates to a mass spectrometric method for determining microbial resistances to antibiotics. The invention provides specific methods comprising cultivation in synthetic media, in which several amino acids, preferably only a single amino acid, are isotopically labeled by incorporating | 11-13-2014 |
20140335557 | APPARATUS FOR COUNTING VIABLE PARTICLES IN LIQUID IN REAL TIME, DIALYSIS FLUID MONITORING SYSTEM AND PURIFIED WATER MONITORING SYSTEM USING THE APPARATUS, AND METHOD OF COUNTING VIABLE PARTICLES IN LIQUID IN REAL TIME - A viable particle counting apparatus | 11-13-2014 |
20140335558 | Method for the Characterization of Microorganisms on Solid or Semi-Solid Media - The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms. | 11-13-2014 |
20140342396 | FERMENTATIVE PRODUCTION OF LIPIDS ON AN INDUSTRIAL SCALE USING CHEMICALLY DEFINED MEDIA - We describe the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemically defined medium include fungal, yeast and bacterial strains. Suitable strains can be obtained as wild type strains or by screening and selection after mutagenic treatment or DNA transformation. | 11-20-2014 |
20140342397 | Particle Detection Device and Method - The invention relates to a device and a method for detecting particles, in particular parasites, in drinking water adapted to on-line application. In particular, the invention b) relates to a method for detecting parasites in water, said method comprising: Passing at least a part of the water through a filter; Applying indirect sonication with ultrasound to said filter to release parasites which have been collected in said filter without disrupting said parasites; Collecting parasites for detection; and Detecting the collected parasites. This serves to collect parasites in the filter and/or increase the concentration of parasites before the filter and/or disrupt aggregates without disrupting the parasites per se. The invention further relates to a concentration device for filter filtration concentration of particles from a volume of a fluid. The concentration device comprises an ultrasonic transducer that is configured to clean the filter. | 11-20-2014 |
20140349334 | NON-INVASIVE IMAGING TO THE BLASTOCYST STAGE FOR THE DETECTION OF HUMAN EMBRYONIC ANEUPLOIDY - Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid. | 11-27-2014 |
20140349335 | METHOD OF DETECTING A BIOLOGICAL ACTIVITY - The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative. | 11-27-2014 |
20140356901 | Method and Device for Detecting Device Colonization - Technologies are generally described for a method and a device for detecting device colonization. Disclosed herein is an indwelling medical device configured to detect a biofilm. The device comprises a substrate configured to contact blood and a detecting material, disposed with the substrate, configured to detect the presence of a biofilm thereon. The detecting material is soluble in blood, removable by kidneys from the blood, and passable to urine by the kidneys for detection in the urine. A method for detecting the growth of a biofilm on an indwelling medical and a method for making an indwelling medical device are also disclosed herein. | 12-04-2014 |
20140356902 | Method for Discovering Algal Strains with Reduced Pigment to Attain Higher Photosynthetic Efficiency - A method for determining and/or engineering photosynthetic mutant algal strains comprising: (A) pre-screening wild-type or parent strains to select for photosynthetic efficiency; (B) cause genetic mutations in the group of wild-type and/or parent strains from pre-screening (A) to form genetic mutant strains; (C) screening the genetic mutant strains for photosynthetic efficiency in mass cultures; and (D) further screening the genetic mutants resulting from screening (C) by measuring biomass productivity to select strains having relatively high biomass/lipid/starch productivity. | 12-04-2014 |
20140370541 | CELL CULTURE LIQUID/GAS-PHASE CHAMBER DEVICES AND RELATED METHODS, AND EXEMPLARY USE FOR MEASURING ACCUMULATION OF GAS-PHASE NITRIC OXIDE IN DIFFERENTIATED CULTURES OF NORMAL AND CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS - Embodiments disclosed herein include cell culture liquid/gas-phase chamber devices and related methods that allow measurement of gas-phase components and their production rate as well as substances/mediators released into media by cultured cells in response to various stimuli. In embodiments disclosed herein, these chamber devices are cell culture liquid/gas-phase chamber devices. The gas and liquid phase compartments are separated by the cell culture liquid/gas-phase chamber devices so that there is no, or minimal, physico-chemical interaction between the liquid and gas phase compartments. As an example, these cell culture liquid/gas-phase chamber devices can be used to study the effects of various pharmacologic agents or other interventions on healthy or diseased cell metabolism by assessing a release of metabolic products in liquid (culture media) and the headspace under standardized conditions. The reusable cell culture chamber devices allow for studying cultured cell responses under a short or prolonged incubation time. | 12-18-2014 |
20140377795 | SPECTROSCOPIC MEANS AND METHODS FOR IDENTIFYING MICROORGANISMS IN CULTURE - A spectroscopic method for spectroscopic detection and identification of bacteria in culture is disclosed. The method incorporates construction of at least one data set, which may be a spectrum, interference pattern, or scattering pattern, from a cultured sample suspected of containing said bacteria. The data set is corrected for the presence of water in the sample, spectral features are extracted using a principal components analysis, and the features are classified using a learning algorithm. In some embodiments of the invention, for example, to differentiate MRSA from MSSA, a multimodal analysis is performed in which identification of the bacteria is made based on a spectrum of the sample, an interference pattern used to determine cell wall thickness, and a scattering pattern used to determine cell wall roughness. An apparatus for performing the method is also disclosed, one embodiment of which incorporates a multiple sample analyzer. | 12-25-2014 |
20140377796 | COMPOSITION OF DETECTION AGENTS FOR EPITHELIAL TUMOUR CELLS AND PREPARATION METHOD THEREFOR - Provided is a composition of detection agents for living cells, especially epithelial tumor cells; the composition contains 0-5% folic acid, 0-10% folic acid complex, 0.01-5% methylene blue, 0.1-10% carbohydrate reducing agent, 2-6% acetic acid, and 3-95% water. Also provided is a preparation method for the composition of detection agents and kits containing the composition of detection agents. | 12-25-2014 |
20150010941 | DETECTION OF ACID-PRODUCING BACTERIA - The disclosure provides culture devices and methods useful for detecting acid-producing bacteria in a sample. The devices include a nutrient medium and a pH indicator to detect and differentiate acid-producing microorganisms, such as lactic acid bacteria. Methods of use include detecting or enumerating acid-producing microorganisms. The methods further provide for the detection of gas-producing acid-producing bacteria. | 01-08-2015 |
20150017681 | DEVICE AND METHOD FOR BIOLOGICAL SAMPLE COLLECTION AND INSPECTION - A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume. | 01-15-2015 |
20150017682 | ANASTOMOTIC LEAKAGE DETECTION THROUGH DUAL ACTION CATHETER - Technologies are generally described for detecting the presence of anastomotic leakage in the abdominal cavity through a dual action catheter placed in the vicinity of a surgery site. A portion of the dual action catheter may be affixed around the surgery site, for example, coiled around the surgery site on the intestine. Through openings on the catheter near the surgery site, a neutral fluid such as saline solution may be injected and extracted through the same openings resulting in retrieval of fluids in the same are. By testing the extracted fluids, chemical and biochemical activity within the abdominal cavity may be determined in order to gauge the start of any anastomotic leakage. | 01-15-2015 |
20150024428 | METHOD OF IDENTIFICATION OF SPORE-FORMING Bacillus spp. BY DIRECT In-situ ANALYSIS OF MALDI-TOF MASS SPECTROMETRY, AND ANALYSIS SYSTEM - A method of the identification of | 01-22-2015 |
20150031074 | COMBINED DETECTION INSTRUMENT FOR CULTURE SPECIMEN CONTAINERS AND INSTRUMENT FOR IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE - A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device. | 01-29-2015 |
20150037834 | FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE - A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: | 02-05-2015 |
20150050688 | SORTING FLOW CYTOMETER - A sorting flow cytometer identifies an undesirable drop charge sequence that is preassigned to adjacent drops before the drops have separated from a fluid stream. An example of an undesirable drop charge sequence is a sequence of adjacent drops that are charged with sufficiently high opposing charges that, after the drops are formed, would result in merging of the adjacent drops. The sorting flow cytometer adjusts the assignment of drop charges to avoid the undesired drop charge sequence. | 02-19-2015 |
20150064741 | METAL WORKING FLUID COMPOSITION AND METHOD OF DETECTING FLUID DETERIORATION - A wear-indicating metalworking fluid is provided that includes a lubricant base; and a wear-indicating agent. A method of determining wear in a metalworking fluid includes providing wear-indicating metalworking fluid that contains a lubricant base and a wear indicating agent; and observing the visual appearance of the metalworking fluid. A change in visual appearance of the metalworking fluid when compared to an unused metalworking fluid indicates wear of the metalworking fluid. | 03-05-2015 |
20150064742 | SAMPLE ANALYZING METHOD AND SAMPLE ANALYZER - Disclosed is a sample analyzing method comprising: flowing a measurement specimen prepared by mixing a sample and reagent through a flow cell; irradiating particles in the measurement specimen flowing through the flow cell with linearly polarized light and thereby producing scattered light; detecting a change of polarization condition of the scattered light produced by the particles; and discriminating erythrocytes from crystals in the measurement specimen based on the change of polarization condition. | 03-05-2015 |
20150072374 | PASSIVE MICROFLUIDIC DEVICE AND A METHOD OF FORMING THE SAME - According to embodiments of the present invention, a passive counter flow free microfluidic device for sorting a sample of flagellated cells is provided. The passive counter flow free microfluidic device includes an input reservoir configured to receive the sample of flagellated cells, an output reservoir positioned downstream of the input reservoir, the output reservoir configured to collect the flagellated cells that are sorted, and a plurality of microchannel sections arranged sequentially and in fluid communication with each other between the input reservoir and the output reservoir, and designed to define a closed microchannel system between the input reservoir and the output reservoir, wherein each microchannel section comprises at least one microchannel, wherein an inlet of the microchannel of a first microchannel section of the plurality of microchannel sections is connected to the input reservoir, wherein an outlet of the microchannel of a last microchannel section of the plurality of microchannel sections is connected to the output reservoir, and wherein, for each microchannel section, the total volume of the microchannels of one microchannel section of the plurality of microchannel sections is larger than that of the respective in said downstream direction subsequent microchannel section of the plurality of microchannel sections for sorting the flagellated cells when the flagellated cells move from the input reservoir to the output reservoir. | 03-12-2015 |
20150072375 | GENETICALLY ENCODED PROBE FOR QUANTIFICATION OF LACTATE AND METHODS FOR QUANTIFYING METABOLIC RATES AND LACTATE TRANSPORT - A nanosensor for detecting and quantifying lactate in different types of samples, such as tissues, intra-cellular and subcellular compartments, with high spatial and temporal resolution is disclosed. Methods comprising use of the nanosensor for quantifying the activity of lactate transporters, rates of cellular lactate production and cellular lactate consumption, and rate of mitochondrial pyruvate consumption are also disclosed. Methods for quantifying the transformation in energy metabolism that characterizes cancer cells with single-cell resolution and for detecting interference of candidate drugs with mitochondrial energetics are additionally disclosed. | 03-12-2015 |
20150072376 | TRYPTOPHAN AS THE FINGERPRINT FOR DISTINGUISHING AGRESSIVENESS AMONG CANCER CELL LINES USING NATIVE FLUORESCENCE SPECTROSCOPY - Tryptophan is used as the key native marker in cells to determine the level of aggressiveness of cancer cell lines using the native fluorescence spectroscopy. A ratio R of the fluorescence from tryptophan at 340 nm to that from the NADH at 440-460 nm is demonstrated to be associated with aggressiveness of the cancer cells. The higher the ratio R, the more aggressive the tumor towards metastasis. | 03-12-2015 |
20150087014 | METHODS OF SELECTING ALGAE STRAINS FOR PRODUCTIVITY AND ROBUSTNESS - Systems and methods are provided to select strains of algal cells for biomass accumulation. Based on synthetic algae sample trajectories, an illumination profile is developed. Strains of algal cells co-cultured in a vessel can then be exposed to the illumination profile under controlled conditions. Properties of algae can be measured and superior strains selected for further cultivation and/or study. | 03-26-2015 |
20150087015 | Closing Element for Closing a Container for Samples for Analysis - The application relates to a closing element for closing a container for samples for analysis, particularly biological samples. The application also relates to an assembly of a container and a closing element connected to the container. The application also relates to a device and method for analysing samples. The closure comprises a vent channel ( | 03-26-2015 |
20150087016 | Method For Processing Blood Sample - A method for processing a blood sample is provided that can improve the recovery rate of deformable rare cells that would easily pass through a filter and small rare cells while reducing the filtration area of the filter, and that can recover the rare cells alive. | 03-26-2015 |
20150087017 | DEVICE FOR BACTERIA CLASSIFICATION AND PRETREATMENT DEVICE FOR BACTERIA TEST - When automatically classified results are different from judgment of a laboratory technician, the laboratory technician has to reselect the bacterial colonies one-by-one to be a pickup colony through watching the displayed image. To get rid of the inconvenience, provided is a pretreatment device for a bacteria test comprising: a specification unit by which an operator instructs to specify the number of bacterial colonies and the increased/decreased number of the bacterial colonies to be displayed; and a display unit for displaying classification results obtained following the operator's instruction. The pretreatment device for a bacteria test facilitates the automatically classified results to be brought close to the judgment of the laboratory technician, resulting in the saving of the time required for checking the appropriate bacterial colonies for the pickup colony. | 03-26-2015 |
20150093775 | SYSTEM AND METHOD FOR ANALYTE SENSING AND MONITORING - An analyte sensing and monitoring system and method is provided that is particularly applicable to monitoring of analytes in cell cultures. The system and method relies on the initial diffusion rates of the analytes from the medium that contains the analytes being measured (e.g., cell culture) into a diffusion chamber that is inserted into the medium, and remote sensing of the analytes using an analyte sensing system that is coupled to the diffusion chamber. | 04-02-2015 |
20150093776 | POLYPHENOL, TERPENOID, GLYCOSIDE, AND ALKALOID PRODUCTION BY CROCUS SATIVUS CELL CULTURES - A method for producing metabolites of | 04-02-2015 |
20150093777 | METHODS FOR DETERMINING AND/OR MONITORING CONDITIONS OF A THREE DIMENSIONAL CELL CULTURE SYSTEM AND OPTICAL SENSOR DEVICE FOR CONDUCTING SAID METHODS - A method for at least one of determining and monitoring at least one condition of/in a three dimensional cell culture system comprising at least one growth section, the at least one condition being selected from the group consisting of a physiological condition, a vitality, and a metabolism status, the method includes determining the physiological condition using erythrocytes as detectors, determining and/or monitoring the vitality by measuring living cell fluorescent dyes, and determining and/or monitoring the metabolism status by at least one of measuring an autofluorescence of NADH and/or FAD, by determining a NADH/NAD | 04-02-2015 |
20150093778 | VIBRIO ASSAY METHODS AND KITS - Methods and kits for detection of bacteria, especially | 04-02-2015 |
20150093779 | SYSTEM AND DEVICE FOR CHARACTERIZING CELLS - A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis. | 04-02-2015 |
20150099272 | APPARATUS FOR MEASURING FLOATING MICROORGANISMS IN A GAS PHASE IN REAL TIME USING A SYSTEM FOR DISSOLVING MICROORGANISMS AND ATP ILLUMINATION, AND METHOD FOR DETECTING SAME - The present invention relates to a method for measuring airborne microorganisms in real time using a microorganism lysis system and ATP bioluminescence, the method including sampling the airborne microorganisms in a particle classification device to which an ATP-reactive luminescent agent is applied and, at the same time, lysing the microorganisms in a microorganism lysis system under continuous operation to extract adenosine triphosphate (ATP) of the microorganisms sampled in the particle classification device, thus inducing a luminescent reaction between the ATP-reactive luminescent agent and the ATP of the particle classification device in real time; and measuring the concentration of microorganisms using a light receiving device. According to the detection method using ATP organism illumination, the floating microorganisms in the gas phase can be readily detected and the detection can be automatically conducted in real time without manual labor. | 04-09-2015 |
20150118705 | APPARATUS AND METHOD FOR PROCESSING A SAMPLE - An apparatus and an assembly for processing a sample are provided. The apparatus comprises a plurality of spaced-apart reservoirs, a plurality of channels, and a plurality of outlets, each outlet comprising an effluent discharge opening. The apparatus forms a plurality of flow paths, each flow path comprising a reservoir, a channel, and an outlet. An analyte capture element can be slideably engaged in a channel in a position where it is in fluid communication with the flow path. The apparatus with the analyte capture element disposed in the flow path can be used to process a liquid sample. A method of detecting an analyte in the liquid sample is also provided. | 04-30-2015 |
20150118706 | URINE SAMPLE ANALYZER AND URINE SAMPLE ANALYZING METHOD - Disclosed is a urine sample analyzer for analyzing particles contained in a urine sample and outputting analytical results. The analyzer includes a flow cell that accepts a measurement specimen, the measurement specimen comprising a urine sample mixed with a reagent, a light irradiation unit positioned to irradiate the flowing measurement specimen with light, a light detector that detects light from individual particles in the flowing measurement specimen, and a data processor that receives signal from the light detector, processes the signal to obtain parameter information corresponding to a length of a cell cluster, and classifies fungi in the measurement specimen into groups by using the parameter information. | 04-30-2015 |
20150118707 | METHOD AND DEVICE FOR DETECTING METABOLLICALLY ACTIVE CELLS - A method for the detection of metabolically active cells using microwells is provided. A sample containing one or more cells is segmented into a plurality of microwells each containing a metabolic indicator. The microwells are then monitored for a change in the level or activity of a metabolic indicator, thereby indicating the presence or absence of metabolically active cells in each microwell. Also provided are methods for the detection of cells such as bacteria that are resistant to antibiotics or for the detection of particular cell types such as mycobacteria. Also provided are screening methods for identifying compounds with an effect on cell growth or metabolism. | 04-30-2015 |
20150125897 | FAST THERMO-OPTICAL PARTICLE CHARACTERISATION - The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) ofindividual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius). | 05-07-2015 |
20150125898 | COMPOSITIONS AND KITS FOR DIAGNOSING INFECTIONS - The present invention is directed to the use of isotopically labeled citrulline for diagnosing the presence or absence of a bacterial infection in the lungs of a patient. | 05-07-2015 |
20150132794 | METHOD OF MANUFACTURING SAMPLE CONTAINERS - A method of manufacturing a batch of sample containers optimized for culturing particular animal cells or binding particular proteins under particular growth conditions. When a customer requires a batch of sample containers, an appropriate surface is first selected by a testing process. A test container is provided which has a surface subdivided into a plurality of test areas, for example in a two-dimensional square array. Each test area has a pre-defined combination of surface properties including a micro- or nano-structure and these properties are varied from test area to test area. The animal cells or protein of interest are then tested under the particular conditions to be used. The test area that provides the ‘best’ conditions is then selected. The manufacture of a production batch of containers is then carried out, wherein the test areas in the production batch all copy the ‘best’ surface structure selected in the test. | 05-14-2015 |
20150132795 | SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES - Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity. | 05-14-2015 |
20150132796 | KIT FOR DETECTING BIOFILMS - The invention relates to a kit for detecting biofilms, which is in particular compatible with the agri-food industry and comprises a biofilm staining solution containing a stain in solution in a dilution phase compatible with the agri-food industry, wherein said stain is Coomassie blue, and a cleaning solution comprising said dilution phase. | 05-14-2015 |
20150147776 | MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 05-28-2015 |
20150291950 | PHOTOCLEAVABLE LINKER - There are provided, inter alia, photolabile compounds and methods useful for the formation of dimers of biological molecules and subsequent dissociation of the dimers. | 10-15-2015 |
20150293010 | Microfluidic Device And Method For Detecting Rare Cells - A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (F | 10-15-2015 |
20150301029 | DIAGNOSTIC METHODS FOR NEURAL DISORDERS - The invention generally relates to optical methods for the diagnosis of neuronal condition by converting a cell from a patient into a neuron and optically evaluating action potentials of that cell in vitro. The cell is transformed with an optical reporter and exhibits an optical signature in response to neural stimulation. Using genome-editing, a control cell can be made that is isogenic but-for a known mutation and a control signature obtained from the control cell. Thus, methods of the invention reveal potential neurodegenerative effects of a mutation as manifested in a patient's genetic context. The optical signature of the cell, or the difference between the signature and the control signature, is correlated to a diagnosis of the neurodegenerative disease | 10-22-2015 |
20150307913 | SPORE DETECTOR - A system and method of detecting spores includes a light source configured to emit a light pulse within a first wavelength range, and a light sensor configured to detect a resulting phosphorescence emitted from one or more desiccated spores phosphorescing within a second wavelength range in a vicinity of the light pulse. The spore detector also includes circuitry configured to trigger emission of the light pulse and record the emitted phosphorescence at a pre-determined time after the light pulse. | 10-29-2015 |
20150308941 | SYSTEMS AND METHODS FOR PARTICLE CLASSIFICATION AND SORTING - A particle analysis system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a proximal end of the microchannel; a plurality of outlets connected to the microchannel at the downstream expanding region; a plurality of fluidic resistors, where each fluidic resistor is connected to a respective outlet; and a particle analyzer configured to measure a size and a position of particles in the microchannel. A particle sorting system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a proximal end of the microchannel; a plurality of outlets connected to the microchannel at the downstream expanding region; and a plurality of fluidic resistors, where each fluidic resistor is connected to a respective outlet. | 10-29-2015 |
20150308953 | INDIVIDUALLY AND FLEXIBLY DEPLOYABLE TARGET-ANALYTE SENSITIVE PARTICULATE PROBES AND METHOD OF MAKING AND USING - Flexibly deployable, discrete, target-analyte sensitive particulate probes and methods of manufacturing and using. The probes each comprise a porous scaffold particle coated with an optically-active, target-analyte sensitive material. The scaffold particle has at least one of (i) a volume of 0.5 to 500 mm | 10-29-2015 |
20150309040 | Megastokes Amino-Triazolyl-Bodipy Compounds And Applications To Live Neuron Staining And Human Serum Albumin FA1 Drug Site Probing - A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes Human Serum Albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described. | 10-29-2015 |
20150322439 | REPLICATIVE MINICIRCLE VECTORS WITH IMPROVED EXPRESSION - The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of said DNA molecules. | 11-12-2015 |
20150322476 | METHODS, DEVICES, AND SYSTEMS OF DETECTING MICROORGANISMS - A rapid, sensitive method of separating and detecting microorganisms from a sample potentially containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample potentially containing microorganisms. The sample may be a chemical (e.g., household cleaners), cosmetic, personal care, pharmaceutical, or consumable (e.g., food or beverage) good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer. | 11-12-2015 |
20150322477 | INFECTION MEDIATED FOAM DISSOLUTION RATE MEASUREMENT - The subject invention concerns methods and materials for determining the presence or absence of bacterial or fungal infection in a blood sample. In one embodiment, a method of the invention comprises exposing an anticoagulant treated blood sample to freezing the sample to a solid, followed by thawing of the sample and then agitation of the sample to develop foam and then observing the rate that foam dissolves. | 11-12-2015 |
20150330898 | Real Time Optical Detection of Bacteria - A system and method for the detection of bacteria on a sample, utilises spectroscopic analysis of the sample and the fluorescent properties of bacteria or other substance(s) or matter associated with the bacteria to identify the presence of bacteria on the sample. A detector analyses light emitted from the sample in response to illumination. The detector | 11-19-2015 |
20150330969 | Short term isotope pulse labeling method for analysing metabolic products in biological samples - The present invention relates to a method for preparation of labeled metabolic products, comprising the steps (a) providing a biological sample in vitro, (b) contacting the biological sample with a labeling buffer comprising a labeled substrate, wherein the substrate comprises at least one carbon atom and represents an educt or intermediate of a metabolic process of the biological sample and wherein the label is a stable isotope, (c) washing the biological sample using a wash-buffer, wherein said wash-buffer comprises a carbon resource such that the biological sample is precluded from carbon deficiency during said washing, wherein said carbon resource comprises the substrate according to step b), wherein said substrate in the wash-buffer may be labeled or unlabeled, (d) quenching the biological sample such that metabolic processes within the biological sample are slowed down or stopped and (e) extracting the labeled metabolic product from the biological sample. The present invention further refers to methods for quantification of labeled metabolic products from biological sample. | 11-19-2015 |
20150337331 | NOVEL EXPRESSION VECTOR - Disclosed are a novel expression vector for efficient expression of recombinant proteins in mammalian cells, a mammalian cell transformed with the vector, and a method for production of the mammalian cell. The expression vector is an expression vector for expression of a mammalian protein and includes a gene expression regulatory site, and a gene encoding the protein downstream thereof, and an internal ribosome entry site further downstream thereof, and a gene encoding a glutamine synthetase further downstream thereof, and a dihydrofolate reductase gene downstream of either the same gene expression regulatory site or another gene expression regulatory site in addition to the former. | 11-26-2015 |
20150344895 | METHODS OF MODIFYING ALGAL CELL GENOMES - A method of introducing a target gene sequence into a primed algal cell, comprising a step of providing a primed algal cell comprising providing an algal cell; introducing into the algal cell an integration cassette comprising at least two site-specific recombination sites and at least one selectable marker gene wherein the at least two site-specific recombination sites are positioned to flank the at least one selectable marker gene; and selecting cells which have incorporated the integration cassette by cultivating the cells in a selective media and selecting growing cells, wherein an ability of the cells to be cultured on the selective media is dependent on a presence of the at least one selectable marker in a genome of the algal cell. The site-specific recombination sites may be compatible. The method includes a further step of effecting targeted site-specific recombinase mediated deletion of the target cassette can be carried out. The site-specific recombination sites maybe heterospecific to permit introduction of target gene(s). The method further comprises a step of providing a target cassette comprising at least one target gene sequence flanked by a type I site-specific recombination site and a type II site-specific recombination site, these sites being capable of recombining with those in the primed algal cell. Moreover, the method includes a further step of effecting targeted site-specific recombinase mediated insertion of the target cassette into the algal genome by effecting recombination between corresponding type I and type II site-specific recombination sites flanking the target gene sequence and located in the algal genome, such that the target gene sequence is introduced into the algal genome replacing the at least one selectable marker. The invention also concerns integration cassettes for use in the method above, as well as an algal cell for use with and modified algal cell produced by the above method. | 12-03-2015 |
20150344978 | NICOTINE RESISTANT MICROORGANISMS - Compositions and methods are provided for enhanced production of ethanol from fermentation of tobacco biomass. Nicotine resistant microorganisms are provided, as well as methods for making these nicotine resistant microorganisms. A biologically pure culture is provided of a nicotine resistant | 12-03-2015 |
20150346100 | METABOLIC IMAGING METHODS FOR ASSESSMENT OF OOCYTES AND EMBRYOS - The invention provides novel non-invasive in vitro to methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies. | 12-03-2015 |
20150346189 | POINT OF CARE SEPSIS ASSAY DEVICE AND METHOD - Disclosed is a point of care sepsis assay comprising a disposable assay cartridge with a sample inlet for a blood sample, a filter to isolate blood plasma, a source of multivalent cations to cause a turbidity change in the plasma sample and a transparent window to measure the change in turbidity and the use of said assay in the diagnosis of sepsis. | 12-03-2015 |
20150351340 | METHOD FOR REMOVING GENETIC LINKAGE IN A PLANT - The current disclosure relates to the field of plants, in particular to the fields of plant breeding and plant genetics. More particular, the disclosure concerns inventive methodology that may be useful in improving plant properties. In particular the invention may be useful in removing linkage drag. Also provided are plant and plant parts obtained with the method disclosed herein. | 12-10-2015 |
20150353982 | MICRO-EVOLUTION OF MICROBES - An enclosed bioremediation system utilizing resistant micro-evolved microbes for treatment of wastewater and recovery of chemicals and metals and which also results in biomass and biochemical production and carbon capture. | 12-10-2015 |
20150355073 | SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES - A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet. The fluidic pathway includes a delivery region configured to receive the plurality of particles from the inlet and focus the plurality of particles from a random distribution to a focused state, a deformation region defining an intersection located downstream of the delivery region and coupled to the outlet, and wherein the deformation region is configured to receive the plurality of particles from the delivery region and to transmit each particle in the plurality of particles into the intersection from a single direction, a first branch fluidly coupled to the deformation region and configured to transmit a first flow into the intersection, and a second branch fluidly coupled to the deformation region and configured to transmit a second flow, substantially opposing the first flow, into the intersection, wherein the first flow and the second flow are configured to induce extension of one or more particles in the plurality of particles. | 12-10-2015 |
20150355168 | FLUORESCENT CELL CYCLE PROBE HAVING M-PHASE SPECIFICITY - The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells. | 12-10-2015 |
20150361513 | BACTERIAL CULTURES OF ACIDITHIOBACILLUS THIOOXIDANS AND THEIR USE IN THE TREATMENT OF MATERIALS CONTAINING SULFUR-COMPOUNDS - Bacterial cultures of | 12-17-2015 |
20150362481 | METHOD FOR THE IDENTIFICATION OF BITTER TASTING COMPOUNDS AND BITTER TASTE MODULATING COMPOUNDS - The present invention is directed to a method for the identification of bitter tasting compounds and bitter taste modulating compounds, in particular bitter taste masking compounds (bitter antagonists) and bitter taste enhancing compounds (bitter agonists) by monitoring the change in the intracellular pH value and/or proton secretion. | 12-17-2015 |
20150368606 | AUTOMATED TRANSFER MECHANISM FOR MICROBIAL DETECTION APPARATUS - The present invention is directed to a method and automated transfer means for transferring a container within an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system. | 12-24-2015 |
20150368689 | VIABILITY STAINING METHOD - The invention relates to a method of detecting viable cells in a cell sample, using a membrane permeable fluorescent label that permeates both viable and non-viable cells and a membrane impermeant quencher that selectively permeates non-viable cells. | 12-24-2015 |
20150369738 | RED FLUORESCENT ALDEHYDE DEHYDROGENASE (ALDH) SUBSTRATE - A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein. | 12-24-2015 |
20150369790 | AGGREGATED CELL EVALUATION METHOD AND AGGREGATED CELL EVALUATION DEVICE - An aggregated cell evaluation apparatus includes a laser light source, a speckle image acquisition unit, an SC calculation unit, an evaluation unit, and a memory unit. The speckle image acquisition unit acquires a two-dimensional speckle image by forward scattered light generated in aggregated cells by irradiation of the aggregated cells with laser light output from the laser light source. The SC calculation unit calculates a speckle contrast value K | 12-24-2015 |
20150376650 | METHODS AND COMPOSITIONS FOR MODIFYING A TARGETED LOCUS - Methods and compositions are provided for modifying one or more target loci in a cell. Such methods comprise providing a cell comprising a first polynucleotide encoding a first selection marker operably linked to a first promoter active in the cell, wherein the first polynucleotide further comprises a first recognition site for a first nuclease agent. A first nuclease agent is introduced into a cell, wherein the first nuclease agent induces a nick or double-strand break at the first recognition site. Further introduced into the cell is a first targeting vector comprising a first insert polynucleotide flanked by a first and a second homology arm that correspond to a first and a second target site located in sufficient proximity to the first recognition site. At least one cell is then identified comprising in its genome the first insert polynucleotide integrated at the target locus. | 12-31-2015 |
20150377785 | PARTICLE DETECTING DEVICE AND PARTICLE DETECTING METHOD - A particle detecting device includes: a storing device that stores first boundary information wherein the third light intensity is recorded in a first range at a discriminating boundary for particles of first and second classifications, second boundary information wherein the third light intensity is recorded in a second range at a discriminating boundary for particles of first and second classifications, and discriminating information wherein identifiers for particles of the first and second classifications are recorded in cells bounded and not bounded by the discriminating boundary, respectively; and a particle identifying portion that evaluates a particle being measured as a particle of the first classification when the identifier for a particle of the first classification is acquired based on the measured values for the first and second light intensities and the measured value for the third light intensity falls between the first and second boundary values. | 12-31-2015 |
20160002306 | FUSION PROTEINS AND METHODS FOR IDENTIFYING BROMODOMAIN INHIBITING COMPOUNDS - The present invention relates to fusion proteins comprising at least one chromatin binding module and at least one reporter module, wherein a plurality of fusion proteins are capable of forming foci, and associated methods for identifying bromodomain inhibiting compounds. | 01-07-2016 |
20160010136 | Methods And Materials For Detection Of Biologicals | 01-14-2016 |
20160017400 | Method for improved detection of microorganisms and the like - A method is provided of applying a test sample to a fibrous pad containing growth media which uses unaccelerated dispersion and deposition of the microorganism. | 01-21-2016 |
20160017402 | Method and apparatus utilizing enzyme substrates producing slow diffusing fluorescent product appearances and chromogens, and use in combination with fast diffusing product appearances - A new method of rapid detection of cells, microorganisms, or other items is described using various combinations of indicator enzyme substrates which can be used to yield fluorophoric and chromophoric appearances due to enzymatic activity. One aspect of the invention is the use of a family of compounds that can be used to produce slow diffusing fluorophoric appearances. Another aspect is a family of compounds identified as dual enzyme substrates that can be used to produce both fluorophoric and chromogenic appearances. | 01-21-2016 |
20160018337 | Color Changing Polymer Films for Detecting Chemical and Biological Targets - A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte. | 01-21-2016 |
20160018389 | MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT - An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided. | 01-21-2016 |
20160024549 | BACTERIAL DETECTION CARTRIDGE - Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection. | 01-28-2016 |
20160025607 | SAMPLE CONCENTRATOR AND METHOD OF USE - The present disclosure provides an assembly for preparing a sample for analysis. The assembly comprises a hollow body comprising first opening, an outlet with a second opening, and a fluid pathway extending therebetween; a filter element operatively interposed in the fluid pathway; and a closure comprising a third opening and a chamber, the closure being slideably engaged with the outlet. The chamber and the outlet are dimensioned so that the outlet is sealingly engaged with the chamber. A method of using the assembly to detect a microorganism is also provided. | 01-28-2016 |
20160025633 | USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM - In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution. | 01-28-2016 |
20160032231 | METHOD AND CULTURE DEVICE FOR DETECTING YEASTS AND MOLDS - A thin film culture device for detecting yeast and mold microorganisms in a sample is provided. The culture device comprises a body comprising a self-supporting substrate having a first major surface and a second major surface; a first adhesive composition disposed on a portion of the first major surface of the substrate; a substantially dry, cold-water-soluble first hydrogel-forming composition adhered to the first adhesive composition; and a plurality of indicator agents. The plurality of indicator agents comprises three indicator agents for detecting distinct glycosidase enzyme activities, an indicator agent for detecting an alkyl esterase enzyme activity, and an indicator agent for detecting a phosphatase enzyme activity, wherein each of the plurality of indicator agents comprises a detectable reporter group. A method of using the culture device is also provided. | 02-04-2016 |
20160033377 | METHODS FOR PROCESSING WHOLE BLOOD SAMPLES, AND COMPOSITIONS FOR USE IN PRACTICING THE SAME - Methods for processing whole blood samples are provided. Aspects of the methods include depleting leukocytes from a whole blood sample to produce a leukocyte depleted sample, and then lysing red blood cells (RBCs) in the resultant leukocyte depleted sample to produce a leukocyte/RBC depleted sample. Also provided are compositions and kits for practicing embodiments of the invention. The methods and compositions find use in a variety of different applications, including the detection of circulating tumor cells (CTCs). | 02-04-2016 |
20160033415 | DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS - Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity. | 02-04-2016 |
20160040211 | CULTURE MEDIUM METHOD AND DEVICE - Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly. | 02-11-2016 |
20160041082 | CELL SORTER SYSTEM AND METHOD - Provided herein are improved cell sorter systems and methods. Such systems and methods provide a self-stabilizing sorter jet to automate calibration, and address the issue of drift in cell sorting systems. The systems and methods presented make it possible to determine and set the charge delay interval automatically with circuitry in the cell sorter. These circuits can set, monitor, and adjust the time delay continuously, allowing for a completely automatic, autonomous, turn-key, self-stabilizing sorter jet. | 02-11-2016 |
20160041097 | BLOOD ANALYZING METHOD AND BLOOD ANALYZER - A blood analyzing method comprises irradiating light on a measurement sample prepared using fluorescent dye so as to produce a difference in fluorescence intensity between reticulocytes and mature red blood cells in a blood sample, detecting scattered light and fluorescent light given off from blood cells in the measurement sample, and obtaining fluorescence data related to the fluorescent light and scattered light data related to the scattered light for each blood cell, determining the possibility of the presence of | 02-11-2016 |
20160044882 | HYDROPONIC COMPOSITIONS AND APPLICATIONS THEREOF - In one aspect, hydroponic compositions are described herein comprising an aqueous medium in contact with a plant, the aqueous medium comprising a functional additive for imparting desired architecture and/or properties to the plant structure. In some embodiments, the functional additive comprises one or more of nanoparticles, spectral additives, and pH indicators. | 02-18-2016 |
20160053293 | MULTI-WELL SAMPLE TESTING APPARATUS AND METHODS OF SAMPLE TESTING USING THE SAME - A sample testing apparatus includes a sample tray defining a planar surface and a plurality of wells recessed relative to the planar surface, and a lid member configured to be sealed about the planar surface of the sample tray. The lid member includes an adhesive layer configured to be sealed to the planar surface of the sample tray, a breathable film layer disposed about the adhesive layer, and a backing layer disposed about the breathable film layer. Methods of using the sample testing apparatus for testing a sample and kits to facilitate such testing are also provided. | 02-25-2016 |
20160054222 | METHOD FOR ANALYZING ATYPICAL CELLS IN URINE, URINE ANALYZER, AND METHOD FOR ANALYZING ATYPICAL CELLS IN BODY FLUID - Disclosed is a method for analyzing atypical cells in urine including: mixing urine, a diluent containing a surfactant, and a nucleic acid staining reagent to prepare a measurement specimen; irradiating the measurement specimen with light to detect scattered light and fluorescence light emitted from cells whose nucleic acids are stained; and detecting atypical cells contained in the measurement specimen distinguishably from white blood cells depending on a first characteristic parameter based on the scattered light and a second characteristic parameter based on the fluorescence light. | 02-25-2016 |
20160060615 | DEVICE FOR THE IDENTIFICATION, SEPARATION AND / OR CELL TYPE-SPECIFIC MANIPULATION OF AT LEAST ONE CELL OF A CELLULAR SYSTEM - The invention, in part, relates to devices for the identification, separation, and/or cell type-specific manipulation of at least one cell of a cellular system. | 03-03-2016 |
20160060678 | SELECTIVE CHROMOGENIC MEDIUM - The invention deals with chromogenic media which are suitable for the selective growth and identification of one or more species of yeast. | 03-03-2016 |
20160061710 | APPARATUS FOR CELL OBSERVATION AND METHOD FOR CELL COLLECTION USING THE SAME - An apparatus for cell observation and a method for cell collection using the same are disclosed. The apparatus for cell selection comprises a first substrate having an opening; and a second substrate having a photoresist unit disposed on a surface thereof, wherein the photoresist unit comprises at least one notch and defines a space which is interconnected with the notch and corresponds to the opening of the first substrate. | 03-03-2016 |
20160067354 | PREPARATIONS OF GOLD/MESOPOROUS SILICA HYBRID NANOPARITCLE AND APPLICATIONS - Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring. | 03-10-2016 |
20160068831 | PHOSPHOKETOLASES FOR IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOIDS - This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids. | 03-10-2016 |
20160069916 | DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION - Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens. | 03-10-2016 |
20160083344 | COMPOUND BASED ON CYANINE SCAFFOLD FOR DIAGNOSIS SEPSIS BY SELECTIVELY DETECT GLUTATHIONE - The present invention relates to a compound based on cyanine scaffold for diagnosing sepsis by selectively detecting glutathione. The compound based on cyanine scaffold according to the present invention has the advantages of maintaining its structure in intracellular environment and of reacting selectively to glutathione only among many amino acids containing thiol group (R—SH) such as cysteine, homocysteine, and glutathione, to produce changes in absorption or fluorescence spectrum, making the compound useful for the detection of in vivo glutathione in biosamples and also for the diagnosis of sepsis characteristically displaying the changes of glutathione concentration. | 03-24-2016 |
20160091401 | GRAM STAINING METHOD WITH IMPROVED DECOLORIZATION OF THE CRYSTAL VIOLET-IODINE COMPLEX FROM GRAM NEGATIVE BACTERIA - Provided herein are methods of staining biological material for the purpose of detecting, and in some examples also identifying, microorganisms. Methods of Gram staining bacteria using a slow-acting decolorizing formulation, such as one that includes 1,2-propandiol or ethylene glycol, can be used to extend the time of the decolorizing step, and thus permit automation of the Gram staining method. Also provided are compositions and kits for performing automated Gram staining on microscope slides. | 03-31-2016 |
20160115470 | CELL FUSION DEVICE AND CELL FUSION METHOD - A cell fusion device includes a chamber including a first input/output portion and a second input/output portion and providing a space through a fluid containing cells flows, at least one cell fusion structure provided in the chamber to form a fluidic channel through which the fluid flows and having a capturing portion adapted to capture the cell in the fluid and a fusion portion connected to the capturing portion and provide a space for fusing at least two cells trapped by the capturing portion and moved into the fusion portion in orders, a deformable membrane structure provided in the capturing portion of the cell fusion structure and configured to actuate to change a cross-sectional area of the fluidic channel of the capturing portion and to selectively capture the cell, and a membrane control portion configured to apply a pressure to the deformable membrane structure. | 04-28-2016 |
20160115517 | GAS TESTING UNIT AND METHOD - Apparatuses and associated methods are described for the efficient evaluation of Cl-containing substrates, and especially for such evaluation conducted locally, or on-site, at a prospective facility for implementation of a biological conversion process for desired end product using a Cl carbon source. The exact composition of a given, industrial Cl-containing substrate, as well as the range in composition fluctuations, are generally difficult to reproduce at a remote facility (e.g., a laboratory or a pilot-scale or demonstration-scale process), as required for the accurate prediction/modeling of com′mercial performance to justify large capital expenditures for commercial scale-up. | 04-28-2016 |
20160116457 | TRANSMEMBRANE PROTEINS AS BIOSENSORS - The invention relates to engineered transporter proteins comprising at least one fluorescent reporter covalently bound to the transporter protein, wherein the transporter proteins of the present invention comprise a structural inverted repeat motif, with the motif comprising a first and second subunit that are structural inverted repeats of one another and that are joined to one another by a polypeptide loop. | 04-28-2016 |
20160122698 | APPARATUS AND METHOD FOR DETECTING AND IDENTIFYING MICROORGANISMS - The present invention is an apparatus for detecting the presence, quantity and identity of one or more microorganisms in a sample and a method for using the same. The apparatus is composed of one or more chambers and a sensing element for sensing microorganisms. In particular embodiments, the sensing element is an array of chemoresponsive dyes deposited on a substrate in a predetermined pattern combination, wherein the combination of the dyes have a distinct and direct spectroscopic, transmission, or reflectance response to distinct analytes produced by the microorganism which is indicative of the presence, quantity and identity of the microorganism. | 05-05-2016 |
20160122794 | SYSTEM, METHOD AND APPARATUS FOR PATHOGEN DETECTION - Systems and methods for pathogen detection are described. A method for pathogen detection comprises collecting a sample from a subject, combining the sample with amplification substances, performing detection operations on the combined sample, analyzing the detection signals, and disposing of the combined sample. Embodiments of an apparatus for pathogen detection comprise a microfluidic disk having a plurality of reaction chambers for combining a sample and amplification substances. Further described apparatuses for pathogen detection comprise a storage unit, a sensor unit and a disposal unit. | 05-05-2016 |
20160122795 | MICROORGANISM CULTURING MATERIAL AND METHOD FOR DETECTING MICROORGANISMS - A sheet-form microorganism culturing material including a water-soluble polymer compound layer and a porous matrix layer in which both high moisture retention capability and colony color formation capability are satisfied. | 05-05-2016 |
20160122797 | MAGNETIC SEPARATION PROCESS USING CARBOXYL-FUNCTIONALIZED SUPERPARAMAGNETIC NANOCLUSTERS - A process including: contacting a plurality of carboxyl-functionalized superparamagnetic nanoclusters with a liquid sample potentially comprising at least one microorganism strain; magnetically separating at least some of the carboxyl-functionalized superparamagnetic nanoclusters from at least a portion of the liquid sample; and, assaying the magnetically-separated superparamagnetic nanoclusters for evidence of the at least one microorganism strain having been non-specifically bound thereto. | 05-05-2016 |
20160123800 | CELL PEELING IDENTIFICATION DEVICE AND CELL PEELING IDENTIFICATION METHOD - The present invention relates to a cell peeling recognizing device and a cell peeling recognizing method. | 05-05-2016 |
20160130630 | METHOD FOR DETECTING CAMPYLOBACTER - A selective isolation medium that is not influenced by existence of ESBL-producing bacteria and can clearly detect | 05-12-2016 |
20160131670 | INCUBATOR, SCHEDULE MANAGEMENT METHOD, AND PROGRAM - An input section of an incubator accepts, from a user, a first input selecting a specified incubation container which registers an observing schedule, and a second input specifying an imaging condition of the specified incubation container in an observing sequence. A calculating section calculates, according to the above-mentioned imaging condition, an observing duration of the specified incubation container from a first data relating to a carrying period of an incubation container and a second data with regard to an imaging duration. A schedule management section extracts, based on a schedule data, a registrable time zone in which an observing sequence of the specified incubation container can be executed without overlapping with previously registered observing schedules, and outputs to display the registrable time zone for presentation to the user. | 05-12-2016 |
20160138069 | Method for Detection of Pseudomonas Aeruginosa (PA) Using Volatile Biomarkers - A method of determining the presence of | 05-19-2016 |
20160145577 | HUMAN MULTIPOTENT EMBRYONIC STEM CELL-LIKE PROGENITOR CELLS - The invention provides a plurality of embryonic stem cell-like progenitor cells, which are isolated from a human tissue by a systemic screening of human mesenchymal stromal stem/progenitor cells and a cell sorting by a cell antigen selected from the group consisting of CD34, CD117, CD133, CD201, GloboH and combination thereof, and cultured in a medium supplemented with at least one or more steroids and one or more growth factors. The cells of the invention express CD34 and exhibit sphere-like clonogenicity in early passages and express multipotent embryonic stem cells (ESCs) like characteristics. | 05-26-2016 |
20160152940 | DETECTION DEVICE, SYSTEM AND METHOD MAKING IT POSSIBLE TO DETECT THE PRESENCE OF A MICRO-ORGANISM IN A SAMPLE OR INSIDE A CONTAINER | 06-02-2016 |
20160153959 | METHOD OF DETECTING OBJECTS | 06-02-2016 |
20160160166 | DEVICE AND METHOD FOR IDENTIFICATION OF MICROORGANISMS - The present invention relates to a device for the identification of microorganisms, comprising:
| 06-09-2016 |
20160160174 | CELL-SORTING METHOD AND ASSOCIATED DEVICE - A method of discriminating a living cell from a dead cell, and a device for implementing the method, the method including: using a lens-free imaging device to acquire a diffraction figure corresponding to a cell; and determining a light intensity on a central area of an elementary diffraction figure associated with the cell. It can thus be determined if the studied cell is a living cell or a dead cell. | 06-09-2016 |
20160161404 | System Using Laser-Scatter Measurement Instrument For Organism Identification And Related Network - An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information. | 06-09-2016 |
20160161464 | STEM CELL DIFFERENTIATION DETERMINATION DEVICE, METHOD, AND PROGRAM - A stem cell differentiation determination device includes an observation image acquisition unit that captures an image of an observation region including a stem cell in time series to acquire at least two observation images, a feature amount acquisition unit that acquires at least one feature amount of the stem cell for each observation image, a determination unit that determines whether or not the stem cell has been differentiated, on the basis of the feature amount, a change information acquisition unit that acquires information about a change in the feature amount between the observation images captured in time series or information about a change in a determination result from undifferentiation to differentiation between the observation images, and an output unit that outputs the information about a change in the feature amount or the information about a change in the determination result. | 06-09-2016 |
20160161488 | SYSTEM FOR IMMUNOTHERAPY TARGETING TUMOR PROPAGATION AND PROGRESSION - Finding biologically relevant cancer markers is key to developing an effective treatment. Once specific antigens have been identified that are present on the cell population responsible for propagating tumors, T cells can be genetically altered to target these antigens and then used for personalized T cell therapy. A method to identify and select peptide antigens that effectively associate with and are presented by host HLA surface molecules originating from tumor cells responsible for the persistence and propagation of a cancer has been developed. The system of using these data to produce T cells engineered to express T cell receptors recognizing the peptide antigens is used in the production of a personalized adoptive T cell therapy for cancer that eliminates the cells capable of tumor propagation and cancer progression. The system is especially useful in the production of cancer treatments to achieve complete durable remission of cancers of epithelial origin. | 06-09-2016 |
20160177318 | NOVEL SELECTION VECTORS AND METHODS OF SELECTING EUKARYOTIC HOST CELLS | 06-23-2016 |
20160202170 | BLOOD ANALYZER, BLOOD ANALYSIS METHOD, AND COMPUTER PROGRAM PRODUCT | 07-14-2016 |
20160202172 | APPARATUS AND METHOD FOR DETERMINING THE MECHANICAL PROPERTIES OF CELLS | 07-14-2016 |
20160202246 | BLOOD ANALYSIS METHOD, CONTROL DEVICE, AND BLOOD CELL ANALYZER | 07-14-2016 |
20160251694 | MASS SPECTROMETRIC DIAGNOSIS OF SEPSIS WITHOUT BLOOD CULTURE | 09-01-2016 |
20160252446 | MICROFLUIDIC DEVICES AND SYSTEMS | 09-01-2016 |
20160252498 | USE OF A REAGENT FOR THE LYSIS OF ERYTHROCYTES AS WELL AS METHODS AND KITS RELATING THERETO | 09-01-2016 |
20160377525 | PARTICLE MANIPULATION SYSTEM WITH CAMERA CONFIRMATION - A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. | 12-29-2016 |
20160377603 | 3D DETERMINATION OF CELL CHIRALITY AND DIAGNOSIS OF DISEASE THEREFROM - Described herein is a method for determining chirality of a cell. The method includes culturing a cell on a base layer having a cell growth material. The method includes forming a top layer on the base layer after the cell has attached to the base layer, the top layer having a cell growth material. The base layer and the top layer form a graded 3D substrate. The intrinsic bias of the cell is determined from the directionality of spontaneous cell rotation. | 12-29-2016 |
20160377637 | METHOD AND APPARATUS FOR DIAGNOSING BONE TISSUE CONDITIONS - Example methods and apparatus are disclosed for diagnosing or assisting a diagnosis of a bone tissue condition. A specimen associated with bone tissue suspected of being infected is irradiated using a monochromatic light source. The specimen may be irradiated in vivo or ex vivo, and/or within a growth medium. Light scattered during the irradiation is gathered and its Raman spectral content is determined to detect one or more pathological calcium phosphate minerals, such as brushite and uncarbonated apatite, resulting from a conversion of carbonated-apatite in the presence of bacteria. | 12-29-2016 |
20170232436 | FERROMAGNET INFUSED MICROSTRUCTURE ARRAY | 08-17-2017 |
20170233691 | SELF-CONTAINED ANAEROBIC CULTURE DEVICE FOR SULFATE-REDUCING MICROORGANISMS | 08-17-2017 |
20170233784 | METHOD FOR DETECTING DRY ROT FUNGUS CONTAMINATION | 08-17-2017 |
20170234878 | COMPOSITIONS FOR DETECTING CANCER CELLS ON A CELLULAR SURFACE | 08-17-2017 |
20180023111 | APPARATUS FOR CHARACTERIZING BIOLOGICAL OBJECTS | 01-25-2018 |
20180024067 | DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS | 01-25-2018 |
20180024136 | Development of ABCG2-Sensitive Fluorescent Probe For Isolation of ABCG2low Neural Stem/Progenitor Cells | 01-25-2018 |
20190145881 | MULTI-SPECTRAL FILTER PROFILING AND QUALITY CONTROL FOR FLOW CYTOMETRY | 05-16-2019 |
20190145955 | SYSTEM AND METHOD FOR DETERMINING FILL VOLUME IN A CONTAINER | 05-16-2019 |
20220136031 | RECEPTACLE FOR DETECTION OF TARGETED PATHOGENS - A receptacle for detecting a targeted pathogen is provided. The receptacle includes a main body configured to accommodate reagent containing ampoules and a specimen collector, a reservoir provided at a distal end side of the main body, and a support extending through the main body in an extending direction of the receptacle. The support includes an inlet that permits passage of the specimen collector into the main body and an outlet that restrictively permits passage of the specimen collector into and out of the reservoir. | 05-05-2022 |
20220136032 | SELECTION MEDIUM FOR BACTERIA BELONGING TO GENUS PSEUDOMONAS AND USE THEREOF - A bacterium belonging to the genus | 05-05-2022 |