| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435700370 | Escherichia coli | 11 |
| 20080293080 | ACTIVE IMMUNIZATION USING A SIDEROPHORE RECEPTOR PROTEIN - The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis. | 11-27-2008 |
| 20100105082 | RAPID DETECTION NANOSENSORS FOR BIOLOGICAL PATHOGENS - An assay test solution, a method for using, and an apparatus for the rapid detection of multiple pathogens using a FRET-based phenomenon. A volume of fluid, possibly containing pathogens, is passed through an intake and combined with an assay solution of quantum dot/antibody-antigen/quencher complexes that dissociate and recombine with the pathogens into quantum dot/antibody-pathogen complexes. The quantum dot/antibody-antigen/quencher and quantum dot/antibody-pathogen complexes are captured on a detection filter which is illuminated by a light source. The quantum dot/antibody-pathogen complexes, but not the quantum dot/antibody-antigen/quencher complexes, fluoresce when excited by the light from the light source and the fluorescence is picked up by a photodetector, indicating the presence of the pathogens. | 04-29-2010 |
| 20100297677 | CYCOCHROME C SYNTHESIS INHIBITORS - The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis. | 11-25-2010 |
| 20110097745 | Method For Detecting Microbes - The invention provides means and methods for determining the presence of infecting microbes in a liquid. The method comprises steps of introducing the liquid to the sample container of a microbial analyzer, the sample container further containing nutrients. Other steps include carrying out a first incubation of said specimen, adding bioluminescent tester microbes to the specimen, carrying out a second incubation of the specimen and measuring bioluminescence, thereby determining said presence and/or concentration of infecting microbes. | 04-28-2011 |
| 20110311993 | DEVICE FOR DETECTION OF ANTIGENS AND USES THEREOF - Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed. | 12-22-2011 |
| 20120129194 | Visible Detection of Microorganisms - Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the absence of the target. | 05-24-2012 |
| 20120164666 | Glycoprotein Vesicles and Their Methods of Use - Provided are methods of collecting, detecting and altering cells and molecular entities using glycoprotein micelles and vesicles. Glycoprotein vesicles comprising a glycoprotein micelle, at least a monolayer of lectin and/or a monolayer of biologically active glycoproteins are also provided. The invention further provides methods of detecting protein glycosylation using the vesicles of the invention. | 06-28-2012 |
| 20120219971 | TRANSCRIPTION FACTOR-BASED BIOSENSORS FOR DETECTING DICARBOXYLIC ACIDS - The invention provides methods and compositions for detecting dicarboxylic acids using a transcription factor biosensor. | 08-30-2012 |
| 20130122525 | smFRET WITH MEMBRANE PROTEINS - This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as sm-FRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation. | 05-16-2013 |
| 20130137119 | DETECTION OF BACTERIAL CONTAMINATION IN A SAMPLE - Methods for detecting one or more target bacteria in a test sample are provided. It is shown herein that photosensitizers combined with intense light exposure reduce fluorescing background due to non-bacterial particles. This permits detection of subsequently labeled target bacterial cells (e.g., using a fluorescently labeled antibody) against a largely black background. In particular examples, the methods include incubating the test sample in a growth medium that permits growth of bacteria present in the sample, contacting the sample with a photo-sensitizer; exposing the sample to light under conditions sufficient for the photo-sensitizer to photobleach contaminating non-bacterial particulates present in the sample. The bacteria can then be substantially separated from the sample, thereby generating an isolated bacterial sample. The method can also include contacting the isolated bacterial sample with a binding agent specific for the one or more target bacteria, and detecting the one or more target bacteria. | 05-30-2013 |
| 20140273020 | SYSTEM FOR RAPIDLY DETECTING INFECTIOUS AGENTS USING A HYBRIDOMA-BASED BIOSENSOR - A system for detecting infectious agents in biological samples in real time that includes a sample to be tested for at least one specific infectious agent; and at least one biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested; wherein the biosensor emits a detectable signal when it reacts with the specific infectious agent; wherein the biosensor is a hybridoma cell that naturally expresses an endogenous anti-target antigen specific IgM; and wherein the hybridoma cell has been converted to a B cell receptor biosensor by introducing a detectable reporter gene into the cell. | 09-18-2014 |
