| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435700250 | Erythrocyte | 57 |
| 20080248504 | Agglutination Assay - The invention relates to agglutination assays and related kits, reagents and devices. In particular methods of assaying small analytes having few epitopes are disclosed, by means of using hub moieties to which multiple analytes may be bound by a first epitope, together with a further moiety capable of binding a second analyte epitope and which is also capable of binding to a detectable particle. Stable agglutinated complexes may be so formed, which may used as the basis for various assay formats. | 10-09-2008 |
| 20080261247 | Method of detecting red cell antigen-antibody reactions - A process for the detection of antibodies in a test sample by carrying out the following steps:
| 10-23-2008 |
| 20080261248 | Method of detecting red cell antigen-antibody reactions - A process for the detection of antibodies in a test sample by carrying out the following steps:
| 10-23-2008 |
| 20090081711 | ADDRESSABLE ANTIBODY ARRAYS AND METHODS OF USE - Systems and assay methods are disclosed for detecting an autoantibody in a sample. In certain instances, the systems and methods employ a mass tag releasably connected to an antigen. The tag is thereafter released for detection. A tag can be detected by mass spectrometry or in certain instances the tag is fluorescent. Methods for diagnosing a disease or disorder in a subject are also disclosed. | 03-26-2009 |
| 20090093004 | POTENCY ASSAY - The present invention provides a method for determining the in vitro potency of antibodies, in particular anti-Rhesus D positive antibodies. Such antibodies may e.g. be used in the prophylaxis of hemolytic disease of the newborn (HDN), treatment of idiopathic thrombocytopenic purpura (ITP) and prevention of sensitization to the Rhesus D antigen after mistransfusions of RhD(+) blood to RhD(−) individuals. The invention also provides a method for monitoring the release of label from a RhD(+) red blood cell, a method for determining the ability of an antibody to induce the release of label from a RhD(+) red blood cell, and a method for determining whether a manufactured anti-RhD antibody fulfils a predefined release criterion. The invention further provides a kit for measuring the potency of an antibody. | 04-09-2009 |
| 20090203052 | NOVEL SOLUBLE CD14 ANTIGEN - There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3):
| 08-13-2009 |
| 20090208981 | Method for Analysis of Interaction Between Small Molecules and Cells and Apparatus thereof - A method and an apparatus are provided for analyzing the interaction between small molecules and cells without using density gradient and antibody but using a column packed with identical resin particles. The interactions between cell surface and resin particles resulting in the different retention time of cells treating by different small molecules in the column contributed to examining whether the small molecule could interact with cell or not. This invention can also apply small molecule screening, drug screening through examining the retention time by using the column. | 08-20-2009 |
| 20090305311 | C4D/C4B STANDARD FOR QUANTITATIVE FLOW CYTOMETRY OF HUMORAL TRANSPLANT REJECTION - The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient. | 12-10-2009 |
| 20100136585 | METHOD AND DEVICE FOR THE DETERMINATION OF MINOR CELL POPULATION IN HETEROGENEOUS CELL POPULATIONS - The invention relates to a method for determining one or more cellularly bound analytes in a liquid sample, said method being carried out using a device comprising: at least one feeding zone ( | 06-03-2010 |
| 20100143949 | BIOMARKERS FOR COLORECTAL CANCER - Low molecular weight (LMW) peptides have been discovered that are indicative of colorectal cancer. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting colorectal cancer and monitoring the progression of the disease. The LMW peptides are particularly useful in detecting colorectal cancer during its early stages. | 06-10-2010 |
| 20100184101 | Detection of Antigens Carried by Erythrocytes and of Anti-Erthrocyte Antibodies - The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies, said antigenic molecules carried by the erythrocytes consisting of antigenic molecules carried not only by the erythrocytes, but also by at least one other cell population, other than the blood group antigen molecules, said method comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes or erythrocyte membrane fragment. | 07-22-2010 |
| 20100184102 | DEVICE AND METHOD FOR IDENTIFYING AND DETERMINING BLOOD GROUPS - A device for the determination and/or the detection of erythrocyte blood groups from a whole blood sample, and a process that implements this device, as well as a kit for the determination and the detection of blood groups are disclosed. | 07-22-2010 |
| 20100216171 | Reducing Time to Result for Blood Bank Diagnostic Testing - Methods for reducing time to result in blood bank diagnostic testing with an agitation device and a low ionic strength solution are disclosed. Specifically provided are methods for reducing incubation time for antigen-antibody reactions in an immunohematologic assay by subjecting the assay reactants to incubation with agitation and optionally additionally a low ionic strength diluent. | 08-26-2010 |
| 20100221757 | PATIENT SAMPLE CLASSIFICATION BASED UPON LOW ANGLE LIGHT SCATTERING - An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at leas tone sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation. | 09-02-2010 |
| 20100227337 | Method for Evaluating Risk in Multiple Sclerosis - The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis. | 09-09-2010 |
| 20100240073 | DETECTION OF FALSE RESULTS IN ASSAYS - Methods and reagents are disclosed for detecting a false result in an assay for determining a concentration of an analyte in a whole blood sample suspected of containing the analyte. The method comprises determining by means of the assay a concentration of the analyte utilizing a hemolyzed portion of the blood sample to obtain concentration value 1 and determining by means of the assay a concentration of the analyte utilizing a non-hemolyzed portion of the blood sample and multiplying the concentration times a hematocrit factor to obtain concentration value 2. A ratio of concentration value 1 divided by concentration value 2 is determined and is compared to a predetermined ratio of known reliability. If the ratio is less than the predetermined ratio, a false result is indicated. | 09-23-2010 |
| 20100255509 | DETECTION OF INFECTIOUS DISEASE IN A HUMAN OR ANIMAL BY MEASURING SPECIFIC PHAGOCYTOSIS IN A THIN FILM SAMPLE OF THEIR ANTICOAGULATED BLOOD - A method for performing a target analyte assay of a thin film anticoagulated blood sample, wherein the target analyte is the presence or absence of specific phagocytosis and/or binding of particles coated with a particular antigen or antigens by white blood cells present in the anticoagulated blood sample, wherein the particles are coated with the particular antigen or antigens, which antigens are similar or identical to antigens expressed by a defined pathogenic infectious agent of interest. | 10-07-2010 |
| 20100255510 | RAPID AND SENSITIVE METHOD FOR QUANTITATIVE DETERMINATION OF THE LEVEL OF HEPARIN - PF4 COMPLEX INDUCED IMMUNOGLOBULIN ANTIBODIES - Disclosed herein is a lateral flow immuno-assay system capable of rapidly, cost effectively, and quantitatively detecting and assessing the level of HIT antibodies in body fluids of a patient. Also taught are methods for employing the system to assist in diagnosis of HIT, and for screening or detecting a changing titer of HIT antibodies in the body fluids of a patient to determine susceptibility toward HIT. | 10-07-2010 |
| 20100311086 | Complement-Mediated Thrombophilic Assay - A method for assessing the presence of an acquired thrombophilia disorder in a patient exhibiting hypercoagulation is disclosed. | 12-09-2010 |
| 20100311087 | CELL-BASED ANTIOXIDANT PROTECTION ASSAY - Methods are provided herein for determining antioxidant activity of a test sample in intact cells. The method includes determining the antioxidant capacity of a test sample in intact red blood cells, wherein the test sample is added to intact red blood cells and oxidative damage is measured by alteration of fluorescence intensity of an oxidation-sensitive fluorescent indicator dye. | 12-09-2010 |
| 20100330594 | Early Detection of Diabetes - The present invention is based on the discovery that hexosamine, and in particular the dynamic O-GlcNAcylation of proteins (modification of proteins by the sugar N-acetylglucosamine) both causes insulin-resistance (a hallmark of type II diabetes) and is responsible for glucose toxicity in the disease. Accordingly, the invention provides methods of diagnosing a subject as having or at risk of having pre-diabetes or diabetes. Also provided are methods of characterizing hyperglycemia in a subject, methods of identifying a protein as being associated with hyperglycemia, and kits for detecting pre-diabetes or diabetes. | 12-30-2010 |
| 20110070600 | PARTICLE AGGLUTINATION IN A TIP - An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays. | 03-24-2011 |
| 20110076697 | LATERAL-FLOW IMMUNO-CHROMATOGRAPHIC ASSAY DEVICES - Device including migration membrane, conjugate pad on migration membrane, plasma separation membrane on conjugate pad, pre-filter on plasma separation membrane. Migration membrane has test line configured for loading one or plurality of capture antibodies having specific binding affinity for assay target. Migration membrane configured for allowing lateral flow of blood plasma or serum across migration membrane to test line. Conjugate pad configured for loading one or plurality of detection antibodies having specific binding affinity for assay target. Plasma separation membrane configured for allowing passage of blood plasma or serum and trapping erythrocytes. Pre-filter configured for loading assay sample including erythrocytes and either or both blood plasma and blood serum. Pre-filter configured for allowing passage of blood plasma or serum through pre-filter and causing lateral flow of blood plasma or serum within pre-filter. Method includes providing device and carrying out diagnostic assay cycle. | 03-31-2011 |
| 20110076698 | METHOD OF QUICKLY DETERMINING HUMAN ABO/RH/MN BLOOD TYPE AND A TEST KIT THEREOF - A method of quickly determining human ABO/Rh/MN blood type and a test kit thereof. A blood sample to be detected is applied onto a test strip pre-coated with anti-A or anti-B or anti-M or anti-N antibody, a rinse solution is dripped onto one end of the test strip, and then the blood group of the blood sample is determined by the presence of agglutinated red cells remained at the reaction sites. | 03-31-2011 |
| 20110136152 | SYSTEMS AND METHODS FOR COUNTING CELLS AND BIOMOLECULES - The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection. | 06-09-2011 |
| 20110171666 | PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - Peptide-lipid constructs of the structure L-S—F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of aggluthination of the cells. | 07-14-2011 |
| 20110207151 | Utilisation de ferrofluides pour le phenotypage sanguin et applications derivees - The invention relates to a method for phenotyping blood and/or performing an irregular agglutinin test and/or for determination of compatibility of a donor and receiver, using an aqueous solution of ferrofluid, obtained from a mixture of polyoxoanions of Fe(III) and at least one metal M(II) of oxidation state II. The invention further relates to a kit for carrying out said procedure. | 08-25-2011 |
| 20110306065 | USE OF AN ANTIBODY AND A RARE-EARTH BASED CRYSTAL - The present invention provides compositions and methods for the detection of red blood cells antigens. The methods and compositions are based on antibodies, serving as primary antibodies or secondary antibodies, that are labeled with a rare-earth based crystal. Methods utilizing antibodies labeled with a rare-earth based crystal enhance the efficiency and accuracy of blood compatability tests and red blood cells phenotyping. | 12-15-2011 |
| 20120088253 | METHOD FOR MEASURING GLYCATED HEMOGLOBIN - Provided is a method for measuring glycated hemoglobin. The method includes a hemolysis step of hemolyzing a blood sample with a hemolysate, a reaction step of reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials, a first measuring step of measuring the amount of total hemoglobin in blood, an isolation step of isolating normal hemoglobin from the glycated hemoglobin conjugated with the bead conjugates, a second measuring step of measuring the amount of glycated hemoglobin in blood, and a calculation step of calculating the concentration of glycated hemoglobin in the blood sample based on the measured amounts of total hemoglobin and glycated hemoglobin in the blood sample. | 04-12-2012 |
| 20120088254 | WHOLE BLOOD ASSAY OF AN INTRACELLULAR BIOMARKER OF A CELL SIGNALLING PATHWAY USE IN MEASURING THE ACTIVATION OF A PREDETERMINED CELL POPULATION - A method for assaying by ELISA, carried out on a whole blood sample, of the cellular activation state of a predetermined population of cells of the sample, includes determining the phosphorylation state of an intracellular protein involved in a cell signaling pathway (biomarker). A particular application of the method for assaying the phosphorylation state of an intracellular protein involves monitoring agonist agents or antagonist agents of cellular activation of cellular populations present in a whole blood sample. Such an application may in particular contribute to therapeutic monitoring of patients, or it may be useful in drug screening. In particular, the application pertains to the context of the exploration of hemostasis, in particular blood coagulation, from an observation of the activation of platelets contained in whole blood samples. | 04-12-2012 |
| 20120202225 | METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS - Methods and devices for evaluating a sample from a subject for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell preparation), thus allowing for more efficient detection and reduced test time. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed. | 08-09-2012 |
| 20120214175 | Separation, washing and determination of analytes tagged with magnetic particles - Method for detecting a material of interest, usually an antibody or an antigen on a red blood cell, in a liquid, by observing the potential antigen/antibody reaction products in a novel way. Reaction products are deposited on a magnetic substrate and will exhibit different properties depending upon whether or not the antigen/antibody reaction has taken place. An antigen/antibody reaction product adheres tenaciously to itself and the substrate while the deposit of any unreacted magnetically tagged material is weakly adhering and easily disrupted and dislodged under a disruptive force which would be insufficient to dislodge the reacted deposit. This difference in cohesive property provides the means by which a positive result is distinguished from a negative result. | 08-23-2012 |
| 20120214176 | Detection of specific antigens in a population of antigens - Methods for detecting the presence or absence of, and for quantifying, one set of cells in a mixed cell population of at least two sets of cells especially Rh positive cells in a mixed population with Rh negative cells, as is found in a fetal maternal hemorrhage (FMH). | 08-23-2012 |
| 20120282634 | BLOOD SEPARATION SYSTEM AND METHOD FOR A DRY TEST STRIP - A dry test strip layer for filtering red blood cells includes a Borosilicate Glass Fiber layer and lectin, impregnated in the borosilicate layer, such that the dry test strip is configured to filter red blood cells from a blood sample. | 11-08-2012 |
| 20120295285 | Ordered Assembly of Membrane Proteins During Differentiation of Erythroblasts - Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors. | 11-22-2012 |
| 20120315654 | COMPOSITIONS AND METHODS FOR DETECTING CARDIOTOXICITY - The present disclosure provides methods and compositions for detecting the presence and activity of creatine transporter proteins (CrT) in biological samples comprising screening the samples for CrT using antibodies that bind to the CrT. The methods are useful to detect the onset of cardiotoxicity in subjects undergoing treatment with anthrocyclines or those susceptible to heart-related conditions. The methods and compositions described herein in can be practiced with diagnostic kits. | 12-13-2012 |
| 20120322086 | TESTING DEVICE FOR IDENTIFYING ANTIGENS AND ANTIBODIES IN BIOFLUIDS - A testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one detection zone extending therefrom; wherein the biofluid sample can be mixed with a specific antigen or antibody, and deposited on the collection zone and transferred by capillary action to the detection zone; the antigen or antibody in the biofluid sample reacting with an appropriate said antibody or antigen thereby resulting in a visual indication within the detection zone. | 12-20-2012 |
| 20130130280 | MAGNETIC IMMUNODIAGNOSTIC METHODS AND KIT FOR THE DEMONSTRATION OF ANTIBODY/ANTIGEN COMPLEXES IN ERYTHROCYTE BLOOD GROUPING AND PHENOTYPING - The current invention relates to a magnetic immunodiagnostic method for the demonstration of antibody/antigen complexes of blood group and phenotype. Such a method involves the research and/or identification of antibodies or antigens, preferably anti-antigen antibodies or antigens of a blood group. This method implements a suspension of magnetic particles coated with an antibody anti-glycophorin A that can recognize and specifically magnetize erythrocytes. The invention also includes a device and kit for carrying out one such method. | 05-23-2013 |
| 20130164763 | ANALYSIS DEVICE AND METHOD USING THE SAME - An analysis device includes: a separation cavity | 06-27-2013 |
| 20130260396 | HOLOGRAPHIC FLUCTUATION MICROSCOPY APPARATUS AND METHOD FOR DETERMINING MOBILITY OF PARTICLE AND/OR CELL DISPERSIONS - The present invention relates to an instrument and a measurement apparatus and methodology that yields a measurement and test methodology that characterizes a population of cells/particles or detects a sub-population of cells/particles based on their detected mobility in a quick and efficient manner. | 10-03-2013 |
| 20130273571 | METHOD OF FUNCTIONALIZING HUMAN RED BLOOD CELLS WITH ANTIBODY - The present invention relates to producing more densely functionalized indicator cells which along, with other components, can be used to detect the presence or absence of antibodies or antigens, by using the A, B, AB and MNS antigens which have a greater degree of expression than the conventionally used D antigen to label the indicator cells with IgG. The present antigen systems have levels of expression that approach one million antigens per cell, which is in great contrast to the conventional D antigen sites of about | 10-17-2013 |
| 20130323757 | Method and System for Characterizing the Movement Speed of Particles Contained in a Liquid, such as Blood Particles - The method according to the invention is capable of characterizing a variation in the speed of particles or agglomeration of particles, the particles, such as blood particles, being contained in a liquid ( | 12-05-2013 |
| 20130337475 | DETECTION TARGET SUBSTANCE DETECTING METHOD, DETECTION TARGET SUBSTANCE DETECTING CHIP USED IN THE METHOD, AND DETECTION TARGET SUBSTANCE DETECTING APPARATUS - Expedient and sensitive detection of a detection target substance is enabled in target substance detection that detects the detection target substance at a sensor portion provided within a flow channel. A detection target substance detecting method for a detecting detection target substance which may be contained in a liquid sample emits ultrasonic waves that propagate in a direction transverse to a flow channel when the liquid sample flows within a ultrasonic wave emission region at which ultrasonic waves can be emitted, to concentrate the detection target substance at a wall surface of the flow channel toward the side of the sensor portion and to detect the detection target substance. | 12-19-2013 |
| 20140134648 | METHODS OF DETERMINING THE HEALTH STATUS OF AN INDIVIDUAL - Methods of determining health status based on analysis of single cells in a sample or set of samples from an individual are described. | 05-15-2014 |
| 20140154704 | Monoclonal Antibodies with Specficity for Fetal Erythroid Cells - The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell. | 06-05-2014 |
| 20140206019 | FC-FUNCTION ASSAY - The present invention discloses a method of assaying Fc-function in an immunoglobulin containing sample by contacting the sample, in the presence of a complement, with red blood cells modified to incorporate a F-S-L peptide-lipid construct. The F-S-L peptide construct comprises a functional group (F) that is a target antigen for a complement activating immunoglobulin, a spacer group (S) covalently linking F to L and a lipid group (L). The present invention further discloses a specific construct, DOPE-Ad-CMG(2)-hCMV2 where the F group is an antigen of cytomegalovirus, that is used in assaying the Fc function of an intravenous immunoglobulin (IVIG) product. | 07-24-2014 |
| 20140363827 | APPARATUS FOR IDENTIFYING CHARACTERISTIC OF LIQUID AND THE METHOD THEREOF - An apparatus and a method for identifying the characteristics of a liquid sample due to capillary force are disclosed. The apparatus and the method spread the blood sample (which is obtained from the blood of a subject, or a mixture containing the blood of two different subjects) having an agglutination portion in a distribution space due to the capillary force. | 12-11-2014 |
| 20140363828 | METHOD AND DEVICE FOR ASSAYING AN ANTIGEN PRESENT ON ERYTHROCYTES OR AN ANTIBODY BINDING TO AN ANTIGEN PRESENT ON ERYTHROCYTES - An assaying kit is for pre-transfusion blood group matching between two blood samples. The kit includes at least two assemblies ( | 12-11-2014 |
| 20140370525 | ALPHA-HEMOGLOBIN STABILIZING PROTEIN ANTIBODIES AND METHODS OF USE THEREOF - Methods for detecting and/or imaging erythrocyte precursor cells are provided. | 12-18-2014 |
| 20150024413 | BIOMARKERS OF OXIDATIVE STRESS - The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the β1-subunit of the human erythrocyte ATP-dependent Na | 01-22-2015 |
| 20150140578 | METHODS AND DEVICES FOR SAMPLE TESTING AND EVALUATION - Methods and devices for evaluating a sample from a subject for the presence of a mixed population of cells, e.g., a sample having more than one distinct populations of cells, e.g., red blood cells (RBCs). Also included are methods and devices for Coombs crossmatch and DAT testing. | 05-21-2015 |
| 20150140579 | In Vitro Diagnosis Device and Uses Thereof - The invention relates to an in vitro diagnosis device ( | 05-21-2015 |
| 20160069877 | Detection of Specific Antigens in a Population of Antigens - Methods for detecting the presence or absence of, and for quantifying, one set of cells in a mixed cell population of at least two sets of cells especially Rh positive cells in a mixed population with Rh negative cells, as is found in a fetal maternal hemorrhage (FMH). | 03-10-2016 |
| 20160084837 | MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR FETAL ERYTHROID CELLS - The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell. | 03-24-2016 |
| 20160109467 | MICROFLUIDIC DEVICES AND METHODS FOR PERFORMING SERUM SEPARATION AND BLOOD CROSS-MATCHING - Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction. | 04-21-2016 |
| 20160139124 | METHOD TO BIOENGINEER DESIGNER PLATELETS USING GENE EDITING AND STEM CELL METHODOLOGIES - A method of creating cells expressing specific platelet alloantigens is disclosed. In one embodiment, the method comprises the steps of (a) combining one or more guide RNAs targeting within a platelet alloantigen target locus; (b) adding a repair template comprising a mutation in the target locus flanked by a homology arm on each side, wherein the template may additionally include a diagnostic restriction enzyme site at the target locus; (c) ligating the guide sequence of step (b) into a plasmid which also expresses a nuclease and, optionally, a selectable marker or a reporter gene; (d) transfecting pluripotent cells with the plasmid of step (c) in the presence of an HDR repair oligo; (e) cloning and testing the resulting reporter positive clones for expression of the alloantigen target of interest; and (f) culturing the resulting cells to expand their numbers or to create a differentiated cell type of interest. | 05-19-2016 |
| 20160169913 | METHODS FOR DETECTING A OLIGOMERS | 06-16-2016 |
