Entries |
Document | Title | Date |
20080206440 | Bioabsorbable Polymeric Composition and Medical Device Background - A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration. | 08-28-2008 |
20080213462 | Methods For Coating An Implantable Device - A process for coating an implantable device is disclosed. In this process, at least one implantable device is tumbled. As the implantable device is being tumbled, a coating substance is introduced to coat the implantable device with the coating substance. | 09-04-2008 |
20080213463 | Implantable product with improved aqueous interface characteristics and method for making and using same - An implantable medical device including a porous membrane that is treated with a hydrophilic substance to obtain rapid optimum visualization using technology for viewing inside of a mammalian body. These technologies include ultrasound echocardiography and video imaging such as that used during laparoscopic procedures. | 09-04-2008 |
20080226812 | Stent coating apparatus and method - An apparatus and method for coating abluminal surface of a stent is described. The apparatus includes a stent support, a coating device, and an imaging system. The coating device includes a solution reservoir and transducer assembly. The transducer assembly includes a plurality of transducers and a controller. Each transducer is used to generate focused acoustic waves in the coating substance in the reservoir. A controller is communicated to an image system to enable the transducers to generate droplets on demand and at the predetermined ejection points on the surface of the coating substance to coat the stent. A method for coating a stent includes stent mounting, stent movement, and droplet excitation. | 09-18-2008 |
20080268134 | ELECTRODE WITH INCREASED STABILITY AND METHOD OF MANUFACTURING THE SAME - The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. | 10-30-2008 |
20080274266 | Selective Application Of Therapeutic Agent to a Medical Device - A method of coating an implantable medical device may include providing an implantable medical device, applying a polymer base to the medical device, and directing a first solution including therapeutic agent and solvent through the nozzle onto a target zone of the polymer base coating to penetrate the polymer base coating. The solution may be directed at the target zone until a predetermined concentration of the therapeutic agent can be integrated within the polymer base coating. | 11-06-2008 |
20080280025 | Multi-purpose holding device - This invention relates to a multi-purpose holding device to handle, support and rotate one or more hollow cylindrical objects. The holding device consists of a rigid frame and support members for precise alignment and rotation of one or more objects within the frame structure. A method is also provided to reproducibly support, rotate and inspect the hollow cylindrical objects. | 11-13-2008 |
20080286440 | Process for coating a substrate - A method to coat a substrate for the formation of coatings having a desired surface morphology is provided, wherein the roughness and the total surface area of the coating can be varied during the coating process. The method of the present invention comprises the steps of generating droplets from a coating composition, transporting the droplets to the substrate and depositing a majority of the droplets on the substrate. | 11-20-2008 |
20080292776 | Hydrophilic Coating - The invention relates to a hydrophilic coating formulation which when cured results in a hydrophilic coating, wherein the hydrophilic coating formulation comprises a polyelectrolyte and a non-ionic hydrophilic polymer. The invention further relates to a coating system, a hydrophilic coating, a lubricious coating, use of a polyelectrolyte and a non-ionic hydrophilic polymer in a lubricious coating, an article, a medical device or component and a method of forming on a substrate a hydrophilic coating. | 11-27-2008 |
20080292777 | COATING SLEEVE - The present invention provides an apparatus and a method for modifying a structure such as a medical device through the selective application of a coating. A coating sleeve may comprise an elastomeric wall that may be permeable or impermeable to a coating material and may be porous so as to allow for patterned coating of the device. The coating sleeve may contain surface protrusions that facilitate manipulation by providing sites for grasping and pulling. In operation the coating sleeve may be fitted on the device prior to application of a coating and removed subsequent to application of the coating. | 11-27-2008 |
20080311280 | METHODS AND DEVICES FOR COATING STENTS - Various embodiments of methods and devices for coating stents are described herein. | 12-18-2008 |
20090029030 | POLYMER LINK HYBRID STENT - The present invention is directed to an expandable polymer link hybrid stent for implantation in a body lumen, such as a coronary artery along with a method of making the stent. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of polymeric links. The polymer links are formed by applying polymer layers between the rings and laser ablating the excess material. The polymeric material forming the polymeric links, provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness. | 01-29-2009 |
20090035448 | MEDICAL DEVICE COATING BY LASER CLADDING - Methods for making medical devices having porous coatings. Methods may comprise providing a tubing section having inner and outer surfaces and positioning a nozzle proximate to a target surface of the parent tubing section. A powder form of the porous coating may be delivered toward the tubing section, and a laser may be directed at the powder to melt the powder to form a melt pool. The melt pool can solidify to form the porous coating on the target surface. Portions of the parent tubing section may then be cut away to form the support structure of the medical device, such as a stent. | 02-05-2009 |
20090047413 | CONDUCTIVE THERAPEUTIC COATING FOR MEDICAL DEVICE - An implantable medical device includes a housing and a coating disposed on the housing. The coating includes a conductive carrier and a therapeutic agent, e.g. an anti-infective agent such as silver particles. The conductive carrier can be any suitable conductive material, such as iridium oxide, titanium nitride, diamond-like carbon, graphite, polyaniline, platinum, carbon nanotubes, carbon black, platinum black, or poly 3,4,-ethylenedioxythiophene. Coatings containing iridium oxide and metallic silver particles are effective in inhibiting bacterial growth in vitro. | 02-19-2009 |
20090053392 | Implantable medical devices for local and regional treatment - Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed. | 02-26-2009 |
20090130293 | BIOCOMPATIBLE COATINGS FOR MEDICAL DEVICES - Biocompatible coatings for implantable medical devices are disclosed. Embodiments of the invention provide plasma etch processes, surface silanization processes, and protein coating processes. Embodiments of the invention provide tropoelastin coatings and methods of creating tropoelastin coatings for implantable medical devices. Optionally, the biocompatible coating can be a drug eluting coating. | 05-21-2009 |
20090220677 | METHOD OF MANUFACTURING A COVERED STENT - A method of manufacturing a covered stent having a sufficiently thick covering to retain a therapeutically effective amount of a therapeutic agent. The covering is applied to the entire outer surface of the stent to provide sufficient volume for retention of the therapeutic agent. In certain embodiments, the stent has a plurality of openings that are covered by the covering. The invention is particularly suited for certain applications, such as for the manufacture of non-vascular stents. | 09-03-2009 |
20090232963 | DIAZONIUM SALT MODIFICATION OF SILK POLYMER - A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells. | 09-17-2009 |
20090269479 | Method For Biostable Inclusion Of A Biobeneficial Agent On An Outermost Surface Of An Implantable Medical Device - The current invention is directed to a method of protecting UV or visible light sensitive drugs from the effects of UV or visible radiation used to form covalent bonds between a biobeneficial material and the outermost surface of an implantable medical device in order to lessen the foreign body response to the device. | 10-29-2009 |
20090317537 | Method and System for Selective Coating of Endoluminal Prostheses - A system and method for coating an endoprosthesis involves an applicator capable of delivering a coating substance to the endoprosthesis without spraying. The applicator may have a tube or die through which a coating substance is moved upwards by capillary action or by means of a pump so as to form an accumulation of the coating substance at an upper portion of the applicator. The endoprosthesis can be lowered onto the accumulation, then axially translated or rotated in order to transfer the coating substance to selected portions of the endoprosthesis. The applicator is lowered and/or the endoprosthesis is raised in order to form gaps in the coating. Selective coating of abluminal or luminal surface of the endoprosthesis may also be performed by allowing the surface to skip on a liquid surface of a pool of the coating substance. | 12-24-2009 |
20090317538 | BIOLOGICALLY ACTIVE IMPLANTS - This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate. | 12-24-2009 |
20100003396 | System and Method of Loading and Detecting Beneficial Agent on a Prosthesis - An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path. | 01-07-2010 |
20100021620 | Low Temperature Drug Deposition - A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating. | 01-28-2010 |
20100028526 | THIN FILM COATING METHOD - The invention relates to a thin film coating method using a thin film having minimal adhesion in relation to biological species, of the type comprising the deposition of a thin film with —COOH function. The invention is characterised in that the method includes a step involving the vapour phase chemical decomposition of a carbonaceous precursor containing neither a carboxyl group nor a carbonyl group, in the presence of water. The invention is particularly suitable for use in the field of thin films. | 02-04-2010 |
20100047436 | Method of Making a Cardiac Valve - There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function. | 02-25-2010 |
20100047437 | HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS - A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel. | 02-25-2010 |
20100136211 | IFBM's to Promote the Specific Attachment of Target Analytes to the Surface of Orthopedic Implants - The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant. | 06-03-2010 |
20100143577 | PERCUTANEOUS ACCESS DEVICE SYSTEM FACILITATING CELL GROWTH THEREON - A biocompatible implantable portal is provided that has a wall defining a communicative passage through an interior bore. The exterior of the portal has a neck region adapted to promote autologous cell growth on the neck region. A series of channels are provided on the exterior neck region to facilitate autologous cell growth while disfavoring fluid pooling and bacterial growth. Typical channel widths are from 20 to 300 microns, with adjacent channels being separated by plateaus having a width of between 0 and 600 microns. Providing the portal exterior neck region with a texture varying on a nanometer length scale facilitates autologous cell growth. Applying a coating such as a tissue scaffolding matrix to the neck region prior to implantation also facilitates cell growth. A coupling or a manifold encompassing the neck region facilitates the draw of vacuum and/or mechanical protection for the growing cells. | 06-10-2010 |
20100151113 | MANUFACTURE OF A RADIATING STRUCTURE FOR A MEDICAL IMPLANT - A method of manufacturing a radiating structure having a selected capacitance. The method includes receiving a particular lot of a dielectric material having a nominal permittivity; receiving a measured value of an actual permittivity for the particular lot, the actual permittivity being different from the nominal permittivity; using the actual permittivity, determining the number of laminas of dielectric material required to cause the radiating structure to have the selected capacitance; causing the determined number of laminas of the dielectric material to be formed on a substrate, thereby forming a dielectric layer; and causing the radiating element to form on the layer. | 06-17-2010 |
20100159118 | METHOD FOR PRODUCTION OF BIOCOMPATIBLE IMPLANT - A heat treatment is performed on a base material so that its surface is formed thereon with a titanium oxide film, and then, the titanium oxide film is irradiated with ultraviolet rays, whereby a biocompatible implant is produced. At this time, preferable methods are that for forming a titanium oxide film by heating a base material made of titanium metal or a titanium alloy in an oxidizable gas, and that for forming a titanium oxide film according to a sol-gel method by coating a liquid containing a titanium compound on the surface of the base material, followed by heating. Thereby, a method for producing a biocompatible implant having a titanium oxide film excellent in an ability of forming hydroxyapatite is provided. | 06-24-2010 |
20100166941 | METHOD FOR CONTROLLING DRUG LOADING IN A MEDICAL DEVICE - Systems and relative methods for regulating the loading capacity of a coating sleeve affixed to an outer surface of an implantable medical device to control an amount of antimicrobial agent delivered with the implantable medical device. A coating sleeve defines fibril void spaces into which therapeutic agents are loaded. A clamp is positioned on the coating sleeve to adjust the volume of the fibril void spaces so as to regulate the loading capacity of the coating sleeve. | 07-01-2010 |
20100178414 | SYSTEM AND METHOD FOR MOLDING SOFT FLUID-FILLED IMPLANT SHELLS - Systems and methods for molding shells for fluid-filled prosthetic implants, including spinning and rotating dip- or spray-mandrels during a devolatilization step to ensure an even covering. The mandrels may be spun during the dipping or spraying step, and/or afterward while a solvent evaporates until a gum state is formed. The techniques are particularly useful for forming hollow shells from silicone dispersions for soft implants, such as breast implants. | 07-15-2010 |
20100189879 | Method For Providing An Implantable Electrical Lead Wire - Implantable electrical lead wires, such as cobalt-chromium-molybdenum alloy wires, are coated with a metal, ceramic, or carbon to a thickness of about 100 nm or less to provide a non-reactive interface to polyurethane sheathing materials. Preferred is sputter coating an amorphous carbon intermediate the alloy wire and the polyurethane sheath. | 07-29-2010 |
20100227043 | Oriented collagen gel - Techniques for the production of flow-oriented collagen gels using hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to shear and extensional flow as they are drawn onto a substrate to induce fibrillogenesis under a high Ph buffer. The produced gel captures the flow induced ordering of molecular collagen upon fibril formation. The depositing or the induction of fibrillogenosis occurs without the application of a magnetic field to the concentration of collagen. These highly oriented 3D scaffolds are capable inducing contact guidance and guiding mammalian cell growth. The collagen fibers mimic the construction of in vivo fibers with the characteristic D-periodicity and the integrin receptors on the fibroblasts respond to this organization. The industrial applications of three-dimensional collagen gels as a biomaterial are widespread from drug delivery to burn repair or tissue engineering system. | 09-09-2010 |
20100310756 | Implantable Medical Device Having a Conformal Coating and Method for Manufacture - An implantable electrical medical device and method for manufacturing the same are provided. The method includes forming a conductive substrate, placing the conductive substrate in a deposition chamber; and forming a conformal coating over the conductive substrate using atomic layer deposition. In various embodiments, the conformal coating is a conductive coating and in other embodiments the conformal coating is a dielectric coating. | 12-09-2010 |
20100316787 | Biomimetic Coating Method - A modified method of preparing and applying a biomimetic coating to a medical device substrate surface is described. The modified biomimetic coating method utilizes a solvent mixture of water and an organic water miscible solvent that results in a more efficient coating process, reducing the time required to apply a sufficiently adherent biomimetic coating. | 12-16-2010 |
20100323092 | Stent Coating Device - The present invention is a method and device, which is suitable for use in an operating theater just prior to implantation, for selectively applying a medical coating to an implantable medical device, for example a stent. Disclosed is a device for use with a stent deployed on a catheter balloon. The device is configured to apply a medical coating of a desired thickness to the surface of a stent only. This is done by use of a drop-on-demand ink-jet printing system in association with an optical scanning device. The device is further configured so as to, if necessary, apply a plurality of layered coats, each layered coat being of a different coating material, and if appropriate, different thickness. The section of the housing in which the stent is held during the coating procedure is detachable from the housing base. The detachable housing section may be easily cleaned and re-sterilized or simply disposed of. | 12-23-2010 |
20100330259 | BIOBENEFICIAL COATING COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided. | 12-30-2010 |
20110008528 | METHOD OF COATING A STENT HAVING VARIABLE DRUG RELEASE RATE - A method of coating a stent may comprise applying a composition including a drug and a polymer to the stent to form a coating. The release rate of the drug from the coating gradually increases along a length of the stent which extends axially from opposite ends of the stent. The variable drug release rate can be accomplished by varying the coating thickness, by applying a barrier region over the drug-containing composition, and/or by having different polymers in the coating, the polymers having different drug permeabilities. | 01-13-2011 |
20110020531 | Method for coating medical devices - An apparatus for coating medical devices at the point of care with a polymer and/or therapeutic agent comprising an environmentally controlled device coating chamber in which the device may be delivered by the manufacturer as the device packaging, or the device may be placed into the chamber at the point of care. The environmentally controlled chamber can provide a sterile enclosure in which the polymer and/or a therapeutic agent can be applied to an uncoated or previously coated device and converted to another form (such as a liquid to a film or gel) if desired, under controlled and reproducible conditions. The environmentally controlled chamber can accommodate and provide for coating the device by immersion, spray and other methods of covering the device surface with a liquid or powder. The chamber can provide for energy sources, both internally, such as heat produced by film heaters, and externally, such as UV light or microwave passing through the enclosure. The chamber may allow for changes in atmosphere to affect the coating, such as the introduction of certain gases and introducing pressure or vacuum. | 01-27-2011 |
20110045163 | METHOD FOR PERFUSING A BIOCOMPATIBLE MATERIAL GRAFT WITH A LIQUID AND PERFUSION KIT - A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft ( | 02-24-2011 |
20110064868 | LIQUID AND LOW MELTING COATINGS FOR STENTS - Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms. | 03-17-2011 |
20110070356 | Texturizing Surfaces - Methods for applying surface texture to the exterior of bodily implants, as well as implants made by the methods described. | 03-24-2011 |
20110117267 | Soft Prosthesis Shell Texturing Method - A method of texturing a soft prosthetic implant shell, such as a silicone breast implant shell. A soft prosthetic implant with a textured external surface layer of silicone elastomer and having an open-cell structure is made by adhering and then dissolving round salt crystals. The resulting roughened surface has enhanced physical properties relative to surfaces formed with angular salt crystals. An implant having such a textured external surface layer is expected to help prevent capsular contraction, to help prevent scar formation, and to help in anchoring the implant within the body. | 05-19-2011 |
20110206828 | Devices and Methods for Tissue Engineering - A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue. | 08-25-2011 |
20110217449 | CONTROLLED VAPOR DEPOSITION OF BIOCOMPATIBLE COATINGS FOR MEDICAL DEVICES - An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition. | 09-08-2011 |
20110281022 | Methods For Controlling The Release Rate And Improving The Mechanical Properties Of A Stent Coating - Methods for controlling the release rate and improving the mechanical properties of a stent coating are disclosed. | 11-17-2011 |
20120135130 | METHOD OF MAKING IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES - An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent. | 05-31-2012 |
20120164309 | COATING METHOD AND COATING DEVICE - A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant. | 06-28-2012 |
20120164310 | COATING DEVICE AND COATING METHOD - A device for coating a medical implant includes a container that contains a liquid having at least one pharmaceutically active substance. An elastic head for application of the liquid onto a surface to be coated is connected to an inside of the container through at least one channel. | 06-28-2012 |
20120276279 | PIEZOELECTRIC FILM - A method for producing a biocompatible material of the formula Na | 11-01-2012 |
20120282390 | METHODS OF MODIFYING STENT COATING THICKNESSES - A method of manufacturing a stent includes applying a coating to the stent and changing an amount of the coating being applied to the stent by modifying the diameter of the stent. | 11-08-2012 |
20120321777 | IIMPLANTS AND METHODS FOR MANUFACTURING SAME - A implantable prosthesis having an external surface at least a portion of which is an open-cell structure is made by providing an implantable member having a surface applying a first layer of elastomer to the surface, applying a first layer of particles to the first layer of elastomer, applying a second layer of elastomer to the first layer of particles, applying a second layer of particles to the second layer of elastomer, curing the layers of elastomer, and removing the particles to form an external surface at least a portion of which is an open-cell structure. | 12-20-2012 |
20130040042 | Surgical Mesh Spray and Delivery System - A device for spraying a biological substance onto a biocompatible implant. The device includes a housing that defines a sterile chamber. A spray head is within the chamber and proximate to a first end. A first conduit is configured to direct the biological substance into the chamber through a first spray tip of the spray head. A second conduit is configured to direct an activator into the chamber through a second spray tip of the spray head. A third conduit is configured to direct compressed air to the chamber through a third spray tip of the spay head. The spray head is configured to direct a coating of the biological substance as activated by the activator to the implant seated within the chamber at a second end that is opposite to the first end. | 02-14-2013 |
20130040043 | METHOD OF COATING MEDICAL DEVICES INCLUDING APPLICATION OF PEPTIDE LINKER COATING - Process of manufacturing a medical implant device comprising applying a peptide linker pre-coating to the medical implant device for subsequent coating of a therapeutic agent, wherein the peptide linker contains no therapeutic or other active agents. The method further comprises delivering the pre-coated device to a point of care and applying a therapeutic coating on the pre-coated medical implant device at the point of care. | 02-14-2013 |
20130040044 | METHOD OF COATING MEDICAL DEVICES INCLUDING APPLICATION OF HYDROXYAPATITE COATING - Process of manufacturing a medical implant device comprising applying a hydroxyapatite pre-coating to the medical implant device, delivering the pre-coated device to a point of care and applying a therapeutic coating on the pre-coated medical implant device at the point of care. | 02-14-2013 |
20130045327 | Making a Soft Tissue Prosthesis for Repairing a Defect of an Abdominal Wall or a Pelvic Cavity Wall - Surgical prostheses and methods of using and making surgical prostheses are disclosed. | 02-21-2013 |
20130122184 | COATING METHOD AND COATING DEVICE FOR MEDICAL IMPLANTS - Methods and devices coat, at least regions of, a medical implant, preferably of an artificial joint or a fixation for a joint. The method provides a medical implant, fills a device with a liquid having at least one pharmaceutically active substance, wherein the device has a compressed, at least over regions thereof, elastic, porous transfer means increases a volume of the transfer means, whereby the liquid is taken up at least partly into the pores of the transfer means, and transfers the liquid from the transfer means to a medical implant surface to be coated. The device coats, at least regions of, a medical implant, by means of the method, whereby the device has a compressed, at least over regions thereof, elastic, porous transfer means. | 05-16-2013 |
20130122185 | SURFACE MODIFICATION TO IMPROVE LUBRICITY, ABRASION RESISTANCE AND TEMPERATURE RESILIENCE OF LEADS - A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance. | 05-16-2013 |
20130209661 | PROCESSES FOR MAKING POROUS IMPLANTABLE MATERIALS - Described herein are methods of making open celled foams including a matrix of interconnected spheres. The open celled foams are silicone based materials and can be used to coat implants, such as breast implants, and function to encourage tissue ingrowth and reduce capsular formation. | 08-15-2013 |
20130230636 | MEDICAL MATERIAL FOR IN VIVO IMPLANTATION CONTAINING SOFTENING AGENT AND OR MOISTURIZING AGENT, METHOD FOR CONTROLLING CONTENT OF SOFTENING AGENT AND OR MOISTURIZING AGENT IN THE MEDICAL MATERIAL, AND METHOD FOR PRODUCING THE MEDICAL MATERIAL FOR IN VIVO IMPLANTATION - A medical material for in vivo implantation contains a bioabsorbable material containing a softening agent and/or a moisturizing agent and a non-bioabsorbable porous base material, in which the content of a softening agent and/or a moisturizing agent is controlled less than 20 wt %; a method for controlling this content; and a method for producing a medical material for in vivo implantation are provided. | 09-05-2013 |
20130302509 | ANTIBACTERIAL BIOMEDICAL IMPLANTS AND ASSOCIATED MATERIALS, APPARATUS, AND METHODS - Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process. | 11-14-2013 |
20130302510 | ARTIFICIAL BREAST IMPLANT PROVIDED ON THE SURFACE THREOF WITH SILICON OPEN CELL FOAM LAYER AND METHOD FOR PRODUCING THE SAME - Disclosed are an artificial breast implant in which the surface thereof is formed or modified with a silicone open cell (open pore) foam layer, and a method for producing the same. More specifically, disclosed are an artificial breast implant that has a surface including an open cell foam layer made of silicone and thus minimizes side effects such as in vivo rejection, which may occur after implantation of the implant into the body, in particular, the occurrence of capsular contracture to achieve superior biocompatibility and safety, and a method for producing the same. | 11-14-2013 |
20130302511 | IMPLANTS AND METHODS FOR MANUFACTURING SAME - Implantable prosthesis, components of prosthesis, and methods of making same are provided. The methods generally include the steps of providing an implant shell, applying a curable fluid composition to the shell to form a coating thereon and applying a particulate component to the composition. The composition is a mixture, for example, an emulsion, containing a silicone-based elastomer dispersion and droplets of a suspended leachable agent. After the elastomer is stabilized and cured, the particulate component and leachable agent are removed, resulting in an implantable member having a porous, open-cell surface texture designed to be effective in reducing incidence of capsular formation or contraction. | 11-14-2013 |
20130323403 | ELECTROSPRAY COATING OF OBJECTS - Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g., open matrix coating and closed film coating). | 12-05-2013 |
20130337149 | METHOD FOR MAKING SELF-ASSEMBLING, COLLAGEN-BASED MATERIAL FOR CORNEAL REPLACEMENT - A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting structure is a transparent film of arbitrary thickness very similar in structure to mammalian corneal tissue. | 12-19-2013 |
20140004252 | FUNCTIONALIZED COPOLYMERS OF ISOOLEFINS AND DIOLEFINS AND THEIR USE AS COMPATIBILIZERS | 01-02-2014 |
20140004253 | POST-PROCESSING OF A MEDICAL DEVICE TO CONTROL MORPHOLOGY AND MECHANICAL PROPERTIES | 01-02-2014 |
20140044861 | MULTI-LAYERED SURGICAL PROSTHESIS - The present invention generally relates to the field of prostheses for surgical applications, to methods of their manufacturing and to methods of treating a patient by implanting them into a patient. More particularly, the present invention relates to prostheses having a multi-layered sheet structure and their use in hernia repair, the repair of anatomical defects of the abdominal wall, diaphragm, and chest wall, correction of defects in the genitourinary system, and repair of traumatically damaged organs such as the spleen, liver or kidney. | 02-13-2014 |
20140099427 | METHOD FOR THE MANUFACTURE OF NERVE REGENERATION-INDUCING TUBE - A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution. | 04-10-2014 |
20140113060 | AIR DISENGAGEMENT ASSEMBLY AND METHOD FOR MANUFACTURING DIP-MOLDED ARTICLES OUT OF RTV SILICONE BY FULLY AUTOMATED PROCESS - An automated mandrel dip coating process assembly for RTV silicone dispersions is described, including an enclosure adapted to hold a moisture-cure ambient temperature curable medium for mandrel dip molding and at least one mandrel having a surface for contacting the moisture-cure ambient temperature curable medium. An automated motive drive assembly is arranged to removably translate one or more of the mandrel(s) into contact with the moisture-cure ambient temperature curable medium in the enclosure, and to subsequently translate at least one mandrel contacted with the moisture-cure ambient temperature curable medium into at least one of (A) contact with a bubble crusher in the enclosure, and (B) disengagement from the moisture-cure ambient temperature curable medium in the enclosure and rotation of the mandrel at a vertical displacement angle of from 70° to 110°. By such arrangement, air bubble entrapment on the dip molded film on the mandrel is avoided, and controlled film thickness is achieved at desired location(s) so that the product molded film article is free of pinholes and air bubble inclusions in the film, and complies with desired thickness specifications. | 04-24-2014 |
20140120240 | SILVER NANOPARTICLE ANTIMICROBIAL COATING FOR LONG-TERM AND SHORT-TERM INFECTION RESISTANCE - Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited. | 05-01-2014 |
20140134321 | NITRIC OXIDE-RELEASING COATINGS - Provided according to embodiments of the invention are NO-releasing sol-gel coating formed from a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane. Further provided are methods of producing NO-releasing sol-gel coatings. Such methods may include (a) co-condensing a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; and (c) drying the sol to form the NO-releasing sol-gel coating. | 05-15-2014 |
20140134322 | Nanoparticle Implantation In Medical Devices - Nanoparticles can be embedded into a medical device by accelerating them to a speed of between 100 m/s and 1,000 m/s and embedding the particles into a polymer surface of a medical device or a precursor thereof. In some cases, the nanoparticles can be embedded until the nanoparticles accumulate in sufficient number to adhere together to form a coating over the polymer surface. The nanoparticles can provide a conductive pathway, an abrasion resistant surface, a pro-healing surface, and/or an anti-bacterial surface. | 05-15-2014 |
20140141152 | METHODS AND COMPOSITIONS FOR PROMOTING THE STRUCTURAL INTEGRITY OF SCAFFOLDS FOR TISSUE ENGINEERING - Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers. | 05-22-2014 |
20140242257 | FIBER REINFORCED COMPOSITE STENTS - Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed. | 08-28-2014 |
20140242258 | IMPLANTABLE MATERIALS - A textured breast implant is provided which generally includes a fluid fillable elastomeric shell having a texture defined by struts, for example, hollow struts, defining interconnected open cells. Methods of making the texture include applying a silicone dispersion to a base material and removing the base material from the coating to form a silicone-based structure comprising struts defining interconnected open cells, said struts including internal surfaces defining cavities within the struts. The method may further include the step of contacting the silicone based structure having cavities with a silicone dispersion to cause the silicone to enter and fill the cavities. | 08-28-2014 |
20140248417 | Coatings for the Manufacture and Application of Polyhydroxyalkanoate Medical Devices - Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures. | 09-04-2014 |
20140302227 | Methods of coating a construct with methylated collagen - A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment. | 10-09-2014 |
20140322430 | Surgical Mesh Spray And Delivery System - A device for spraying a biological substance onto a biocompatible implant. The device includes a housing that defines a sterile chamber. A spray head is within the chamber and proximate to a first end. A first conduit is configured to direct the biological substance into the chamber through a first spray tip of the spray head. A second conduit is configured to direct an activator into the chamber through a second spray tip of the spray head. A third conduit is configured to direct compressed air to the chamber through a third spray tip of the spay head. The spray head is configured to direct a coating of the biological substance as activated by the activator to the implant seated within the chamber at a second end that is opposite to the first end. | 10-30-2014 |
20150132469 | IMPLANTS AND METHODS FOR MANUFACTURING SAME - Implantable prosthesis, components of prosthesis, and methods of making same are provided. The methods generally include the steps of providing an implant shell, applying a curable fluid composition to the shell to form a coating thereon and applying a particulate component to the composition. The composition is a mixture, for example, an emulsion, containing a silicone-based elastomer dispersion and droplets of a suspended leachable agent. After the elastomer is stabilized and cured, the particulate component and leachable agent are removed, resulting in an implantable member having a porous, open-cell surface texture designed to be effective in reducing incidence of capsular formation or contraction. | 05-14-2015 |
20150291848 | DIAZONIUM SALT MODIFICATION OF SILK POLYMER - A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells. | 10-15-2015 |
20150327986 | TEXTURED BREAST IMPLANT AND METHODS OF MAKING SAME - Methods for texturing surgical implants, for example, breast implants, are provided. The methods include the use of computer controlled 3D printing of a sacrificial material to create a textured surface on an unfinished surface of the implant. | 11-19-2015 |
20150351929 | PROCESS FOR PRODUCING ROUGHENED SURFACE PATTERNS ON SURFACE OF INTERBODY DEVICES - Processes for producing interbody spinal implants having a body with a top surface, a bottom surface, opposing lateral sides, opposing anterior and posterior portions, a substantially hollow center, and a single vertical aperture; and optionally, one or two integration plates affixed to the body. The processes include applying an additive process, a subtractive process, or both processes to at least one surface of the interbody spinal implant to form a roughened surface topography having a regular repeating pattern. The roughened surface topography is specifically designed to provide certain frictional characteristics, load dispersion, and to influence the biological responses that occur during bone healing and fusion. | 12-10-2015 |
20150359930 | COATED INTRAOCULAR LENS AND ITS MANUFACTURE - An intraocular lens has a hydrophobic lens body ( | 12-17-2015 |
20160022866 | POROUS MATERIALS, METHODS OF MAKING AND USES - The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices. | 01-28-2016 |
20160030975 | ENHANCED LOW FRICTION COATING FOR MEDICAL LEADS AND METHODS OF MAKING - An implantable or insertable medical device can include a silicone substrate and a plasma-enhanced chemical vapor deposition coating on the silicone substrate. The coating may include a silicon-containing compound. A method of forming the coating is also provided. | 02-04-2016 |
20160038652 | METHODS OF APPLYING A HYDROPHILIC COATING TO A SUBSTRATE, AND SUBSTRATES HAVING A HYDROPHILIC COATING - This invention relates to methods of applying to a substrate a hydrophilic coating that becomes lubricious when activated with water or water vapor, and to substrates having such a hydrophilic coating. | 02-11-2016 |
20160151546 | BIODEGRADABLE SUPPORTING DEVICE | 06-02-2016 |
20160158063 | INTRAOCULAR SHUNT MANUFACTURE - An intraocular shunt can be manufactured using a system that includes a liquid bath and a wire, which is moved through the bath. When moved through the bath, the wire is coated with a material, such as gelatin. For example, the liquid bath can have a top layer, including water, and a bottom layer, including gelatin. The coated wire passes through an aperture formed in a plate component of the system. The gelatin can be dried on the wire in a humidity-controlled space, thereby forming the shunt. | 06-09-2016 |
20160175490 | MEDICAL DEVICES WITH AN ACTIVATED COATING | 06-23-2016 |
20160194746 | Surgical Implant | 07-07-2016 |