| Entries |
| Document | Title | Date |
|---|
| 20080260584 | Portable Apparatus For Analysis Of A Refinery Feedstock Or A Product Of A Refinery Process - The present invention provides a portable apparatus for analysis of a refinery feedstock or a product of a refinery process, said apparatus comprising: (a) a first analytical device for determination of the boiling point profile of a refinery feedstock or a product of a refinery process, and (b) at least two further analytical devices each of which contains or is associated with a database and an algorithm, at least one of said devices being adapted for determination of the density of the refinery feedstock or product of a refinery process, and at least one of said devices being adapted for determination of the total acid number of the refinery feedstock or product of a refinery process. | 10-23-2008 |
| 20090022627 | Adsorption fabric and method of fabricating the same - A color-changing adsorption fabric is provided to identify an adsorption state of a type of chemical, e.g., acid, alkali or organic matter, the color change being generated through a chemical reaction between chemical solution and pH-indicator material after wiping the chemical solution with the fabric. An adsorption fabric used in wiping the chemical solution may include a material, whose color changes when contacting an acid, alkali or organic matter, thereby identifying a type of chemical solution and thus preventing or reducing a fire occurrence. The color change of the adsorption fabric used in wiping a chemical solution may be identified with the naked eye so that separating and disposing the used-adsorption fabric corresponding to a type of chemical may be easier. | 01-22-2009 |
| 20090041629 | Method and apparatus for measuring gas sorption and desorption properties of materials - The invention relates to a method and an apparatus (herein referred to as a “gas sorption/desorption analyzer”) for measuring the gas sorption properties of substances (for example hydrogen sorption by metal alloys). Measurements include: Pressure Composition Temperature isotherm (PCT), Kinetic, Cycle-life, and density. Measurements are made by sorption of aliquots of gas to or from a sample of the substance. The amount of gas in each aliquot is determined from the gas pressure and temperature in calibrated reservoir volumes. The apparatus comprises components rated for operation up to 200 atm, a plurality of sensors covering a broad pressure range, and minimized volumes to enable accurate measurements of small samples. Aliquot pressures are controlled using a feed-back controlled pressure regulator that can also be used for constant pressure sorption measurements. The gas temperature is regulated using a temperature controlled enclosure. The apparatus also comprises a plurality of safety and failsafe mechanisms. | 02-12-2009 |
| 20090074619 | DEVICE FOR MEASURING TOTAL ORGANIC CARBON - A device for measuring total organic carbon includes an organic substance oxidative decomposition section ( | 03-19-2009 |
| 20090087346 | Method for Harvesting Nanoparticles and Sequestering Biomarkers - Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid. | 04-02-2009 |
| 20100021346 | SENSING INSTRUMENT - A sensing instrument includes: a reference sensor including a reference piezoelectric resonator not adsorbing a substance to be sensed; a reference oscillator circuit oscillating the reference piezoelectric resonator; a measuring unit receiving an oscillation output of a sensing oscillator circuit and an oscillation output of the reference oscillator circuit in a time-series manner to measure frequencies of the oscillation outputs of the oscillator circuits; and a data creator creating time-series data of a difference between a frequency in a sensing sensor and a frequency in the reference sensor, based on the frequencies of the oscillation outputs of the oscillator circuits obtained by the measuring unit. Therefore, a frequency changed due to a factor other than the adsorption of the substance to be sensed is cancelled. | 01-28-2010 |
| 20100061893 | Sensing Device - An object of the present invention is to provide a sensing device capable of easily grasping whether or not a concentration of a sensing target is equal to or less than a standard value. | 03-11-2010 |
| 20100086442 | Biosensor to Detect Infectious Agents - The present invention provides a sensor for the detection of chemical agents in real time. The sensor includes a sample region having a detector disposed about a substrate where a chemical agent binds to the detector to generate in a signal. The sensor includes a microcontroller in communication with the detector, an analog to digital converter, and a communication module to process the signal into an analytical signal. In addition, the sensor includes an antenna in communication with the microcontroller to enable a wireless communication network, wherein the analytical signal can be transmitted and a power source in operable communication with the microcontroller to supply a source of power to the sensor. | 04-08-2010 |
| 20100135856 | NANOPARTICLE FOR DETECTING BIOMATERIALS AND BIOSENSOR BY USING THE NANOPARTICLE - Provided are a nanoparticle for detecting biomaterials and a biosensor by using the nanoparticle. The nanoparticle includes a metal nanostructure around which an electric field is induced by localized surface plasmon resonance when light is irradiated onto a surface of the metal nanostructure, a spacer covering the surface of the metal nanostructure, and capture molecules specifically reacting with fluorophore-labeled target molecules, and immobilized on a surface of the spacer. | 06-03-2010 |
| 20100158756 | REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS - Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration. | 06-24-2010 |
| 20100166610 | Passive One-Way Valve and Microfluidic Device - This passive one-way valve is used in a connection portion between first and second flow channels, and includes: an inlet portion into which a fluid from the first flow channel flows; an elastic portion for blocking the inlet portion; a rigid portion for supporting the elastic portion from a side opposite to the inlet portion across the elastic portion; a gap portion formed around the rigid portion; and an outlet portion which is in communication with the gap portion for letting the fluid flow out into the second flow channel. Furthermore, the inlet portion is hermetically sealed by the elastic portion being pressed against the inlet portion side by the rigid portion. According to this passive one-way valve, it is possible to provide a simple and inexpensive passive one-way valve without requiring special equipment such as a vacuum pump and pressurized air, and to provide a microfluidic device using the same. | 07-01-2010 |
| 20100172800 | ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES - A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, a layer of antibody immobilized on the surface of at least one of said electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules are conjugated with the antibody to improve electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen. | 07-08-2010 |
| 20100172801 | METHOD FOR UNIFORM APPLICATION OF FLUID INTO A REACTIVE REAGENT AREA - Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air. | 07-08-2010 |
| 20100189601 | CAPILLARY - This invention relates to a capillary channel comprising a first pair of opposing walls defining a width and a second pair of opposing walls defining a depth, wherein the channel has an aspect ratio of 10-100 defined as the ratio of the width to the depth of the channel and wherein an internal surface of at least one of the second pair of opposing walls is roughened. The capillary channel is preferably incorporated into a sensor. | 07-29-2010 |
| 20100209299 | METHOD OF ANALYSIS OF A MIXTURE OF BIOLOGICAL AND/OR CHEMICAL COMPONENTS WITH THE USE MAGNETIC PARTICLES AND APPARATUS FOR ITS EMBODIMENT - Disclosed is an apparatus for analysis of a mixture of biological and/or chemical components that exposes a spatially arranged chosen component attached to magnetic particles to a magnetic field and records a magnetic induction signal from which the content of the biological and/or chemical components is determined. The magnetic field is alternating and has a pre-set spectrum at least at two frequencies. The apparatus records the signal at a frequency which is a linear combination of the at least two frequencies while the magnetic particles are exposed to the magnetic field. | 08-19-2010 |
| 20100233028 | SENSOR ELEMENT FOR SPR MEASUREMENT - An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a sensor element for surface plasmon resonance (SPR) measurement utilizing an SPR effect, wherein the sensor element comprises a transparent substrate, a gold thin film formed on at least a part of the transparent substrate, and a thin film with affinity for a sample provided on the transparent substrate having the gold thin film formed on at least a part thereof, and the thin film with affinity for a sample has a measurement region (region A), a sample introduction section (region B) and a sample absorption section (region C) provided with the region A therebetween, the region A is provided with a sample measurement section containing a molecule-recognizing film, an introduction port is formed on the film with affinity for a sample in the region B, an absorption pad is provided on the film with affinity for a sample in the region C so that the whole region C should be covered, and a point in the region B, a point in the region A, and a point in the region C exist in one straight line on the thin film with affinity for a sample. | 09-16-2010 |
| 20100233029 | COMPENSATED MEMBRANE CAPACITIVE BIO-CHEMICAL SENSOR - A sensor having a membrane, which is adapted to deflect in response to a change in surface stress. The membrane has a first and a second surface, which includes a first coating layer on the first surface of the membrane, and a second coating layer on the second surface of the membrane. The first coating layer is adapted to couple one or more probe molecules with the membrane. | 09-16-2010 |
| 20100233030 | Western Blot by Incorporating an Affinity Purification Zone - An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of the component of interest. In addition, post separation dilution is optionally used to improve detection of the mixture of components and the released component of interest. Microfluidic devices and systems suitable for performing such analyses are also provided. | 09-16-2010 |
| 20100233031 | Method and Apparatus for Analyzing Bioprocess Fluids - Methods and apparatus for analyzing bioprocess fluids are provided. A plurality of particles coated with a plurality of capture agents having an affinity for one or more biological markers is combined with bioprocess fluid to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to a sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface. | 09-16-2010 |
| 20100247382 | FLUORESCENT BIOCHIP DIAGNOSIS DEVICE - Disclosed is a fluorescent biochip diagnosis device including: an image sensor having a plurality of photo-detectors; and a band-pass filter unit having a plurality of band-pass filters formed on a plurality of the photo-detectors, wherein a plurality of the band-pass filters are implemented by forming a nanostructure pattern in a metal layer. Since the fluorescent biochip diagnosis device has little optical loss due to a short interval between the biochip and the photo-detector, excellent sensitivity can be provided. Also, since signals can be simultaneously measured by combining light beams having a short wavelength used as an illumination depending on a type of a fluorescent protein material, cost of the diagnosis device and a diagnosis time can be reduced. | 09-30-2010 |
| 20100254856 | SWELLABLE SOL-GELS, METHODS OF MAKING, AND USE THEREOF - The present invention relates to a method of making a swellable sol-gel composition that involves the use of a bridged silane precursor. The resulting sol-gel includes residual silanols, which are derivatized with a reagent having at least one silanol-reactive group and at least one alkyl group; and the sol-gel is then dried. Sol-gels of the invention are demonstrated to swell up to about 8-10 times their original volume in the presence of a non-polar sorbate. The sol-gel compositions can be used in a sorbate-activated actuator or in a detector for non-polar sorbates. The sol-gel compositions can further be used to take up non-polar sorbates for purposes of chemical remediation, extraction from aqueous systems or vapor, and chemical sensing. | 10-07-2010 |
| 20100266451 | Sensing device - To shorten the time required for an oscillation frequency to stabilize in a sensing device sensing a substance to be sensed by using the fact that a natural frequency of a piezoelectric resonator changes when the substance to be sensed is adsorbed by an adsorption layer formed on the piezoelectric resonator. A sensing device includes: an oscillator circuit | 10-21-2010 |
| 20100272608 | TEMPERATURE SENSOR AND BIOSENSOR USING THE SAME - Embodiments of the invention relates to a temperature sensor and an analytical device comprising the same. The temperature sensor comprises a carrier ( | 10-28-2010 |
| 20100278694 | SILICON BIOSENSOR AND MANUFACTURING METHOD THEREOF - A silicon biosensor and a manufacturing method thereof is provided, the silicon biosensor includes: a light source performing self emission a light detector generating a photoelectric current corresponding to an amount of incident light an optical fiber transmitting the light from the light source to the light detector and a micro fluidic channel adjusting an optical transmission rate of the optical fiber according to an antibody-antigen reaction when the antibody-antigen reaction occurs. The silicon biosensor can be easily integrated or bonded with a silicon electronic device, so that it is possible to manufacture the biosensor with a low price, under mass production. | 11-04-2010 |
| 20100310420 | SENSORS - The invention provides sensors that are useful for detecting and measuring chemical characteristics and physical properties of compositions containing analytes. The invention further provides, among other things, methods for making the sensors and for using them, as well as modified cells having sensors of the invention therein. | 12-09-2010 |
| 20100322823 | Rapid Detection of Post-Vaccination Antibody Response - The present inventions are directed to apparatuses for rapidly measuring post-vaccination immune status. In one version, the apparatus has a support platform, with a top side, a bottom side, a first portion, and a second portion. A first void is integrally formed in the first portion. A container is configured to be removably affixed to the top side of the support platform. The container has a housing, a base, and at least one reactant. The container base can be viewed through the first void when the container is removably affixed to the first portion of the top side. An absorbent material is affixed to the second portion, where the base of the container comes into contact with the absorbent material when the container is removably affixed to the second portion of the top side. | 12-23-2010 |
| 20100322824 | BIOSENSOR CARTRIDGE - The present invention provides a cartridge comprising a sample input portion and a sensor portion, wherein said sensor portion comprises a sensor surface and a first microstructure adapted to provide a capillary force for transporting sample fluid from the sample input portion to the sensor portion, wherein said microstructure does not interfere with the sensor surface. | 12-23-2010 |
| 20100329929 | Methods and Compositions for Highly Sensitive Detection of Molecules - Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution. | 12-30-2010 |
| 20100329930 | STREPTAVIDIN MACROMOLECULAR ADAPTOR AND COMPLEXES THEREOF - A streptavidin macromolecular adaptor (SAMA) protein may be used for the controlled assembly of nanostructure building blocks and struts including streptavidin:SAMA complexes. | 12-30-2010 |
| 20100329931 | SENSING SWITCH AND DETECTING METHOD USING THE SAME - Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch. | 12-30-2010 |
| 20110008212 | CHEMICAL SENSOR HAVING SENSITIVE FILM IMITATING OLFACTORY RECEPTOR - A chemical sensor is provided which has an odor detection and discrimination system imparting selectivity and specificity inherent in living organisms for odor substances to a quartz oscillator or a SAW device and which is able to measure a sample in a vapor phase. The chemical sensor includes a sensitive film using a polypeptide prepared by selecting at least part of an amino acid sequence of an olfactory receptor and imitating the at least part thereof so as to have homology thereto. The chemical sensor preferably has a piezoelectric oscillator including the sensitive film. | 01-13-2011 |
| 20110038758 | Microchip - A microchip, which is used in a diagnostic system using a microfluid system, has a flow path capable of greatly improving the reaction efficiency and realizing a stable measurement with high reproducibility. The microchip has two substrates with at least a flow path | 02-17-2011 |
| 20110044856 | FLUID SPECIMEN COLLECTION DEVICE - A drug test device for bodily fluids, such as urine, includes a cup and a removable lid which houses one or more test strips. The lid is releasably locked onto the cup so as to align dipping ends of the test strips exposed through an underside of the lid with a position stabilizer, thereby causing the dipping ends to be located downwardly and submerged in fluid when the device is placed on its side in a reactive position. The position stabilizer may comprise a sidewall indentation that reduces the internal volume of the cup and keeps the cup from rolling when placed on its side. | 02-24-2011 |
| 20110044857 | METHOD FOR FABRICATING A BIOSENSOR CHIP AND THE BIOSENSOR CHIP MADE THEREBY - A method of fabricating a biosensor chip includes: forming at least one metallic layer on a transparent substrate to form a composite member; disposing the composite member in a vacuumed chamber, and introducing a gas into the vacuumed chamber; applying microwave energy to the gas to produce a microwave plasma of the gas within the vacuumed chamber, and causing the microwave plasma to interact with the metallic layer so that the metallic layer is melted and formed into a plurality of metallic nanoparticles that are spaced apart from each other and that expose partially the surface of the transparent substrate; and disposing a receptor at the surface of the transparent substrate that is exposed among the metallic nanoparticles. A biosensor chip is also disclosed. | 02-24-2011 |
| 20110058985 | ANALYSIS DEVICE AND AN ANALYSIS APPARATUS USING THE ANALYSIS DEVICE - An analysis device comprises a separation chamber for separating a sample solution into a solution component and a solid component, a holding channel, a mixing chamber connected to the holding channel, an overflow channel connected between the holding channel and the separation chamber, a sample overflow chamber into which the sample solution remaining in the separation chamber is discharged, and a joint channel connecting the separation chamber and the sample overflow chamber. After the separated solution component fills the overflow channel with priority, the separated solid component is transferred to the holding channel via the overflow channel, and a predetermined amount of the solid component is measured. The solid component in the holding channel is transferred to the mixing chamber by a centrifugal force, and simultaneously, the sample solution remaining in the separation chamber is discharged to the sample overflow chamber by the siphon effect of the joint channel. | 03-10-2011 |
| 20110064614 | PIEZOELECTRIC RESONATOR AND SENSING SENSOR - Provided is a piezoelectric resonator having high frequency stability and a sensing sensor using the piezoelectric resonator. A piezoelectric resonator has a first oscillation area which is provided in a piezoelectric piece and from which a first oscillation frequency is taken out. A second oscillation area which is provided in an area different from the first oscillation area via an elastic boundary area and from which a second oscillation frequency is taken out. Excitation electrodes are provided on one surface side and another surface side of the oscillation areas across the piezoelectric piece, and a frequency difference between the first oscillation frequency and the second oscillation frequency is not less than 0.2% nor greater than 2.2% of these oscillation frequencies. | 03-17-2011 |
| 20110064615 | PIEZOELECTRIC SENSOR AND SENSING INSTRUMENT - An object of the present invention is to improve detecting ability of a piezoelectric sensor. | 03-17-2011 |
| 20110070127 | Method and Assay for Detection of Residues - Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal. | 03-24-2011 |
| 20110076197 | NANO-FIBERED MEMBRANE FOR WESTERN BLOT AND MANUFACTURING METHOD OF THE SAME - The present invention relates to a membrane for Western blotting which has a three-dimensional open pore structure, an average pore diameter of 0.1-1.0 μm and a thickness of 30-200 μm, wherein the membrane for Western blotting is manufactured by subjecting nanofibers having an average fiber diameter of 50-1000 nm, obtained by electrospinning, to a hot-plate calendering process, and a method for manufacturing the same. The method comprises the steps of: dissolving a hydrophobic material in a solvent to prepare a spinning solution; subjecting the spinning solution to a spinning process to obtain a hydrophobic polymer nanofiber web; and calendering the obtained nanofiber web to obtain a membrane for Western blotting. | 03-31-2011 |
| 20110097240 | ANALYZER USING MAGNETIC PARTICLES - This invention provides an analyzer that uses magnetic particles, the analyzer being capable of removing inhibitors within a short time and reducing an analytical time. Magnetic particles | 04-28-2011 |
| 20110104010 | BINDING REAGENT SYSTEM FOR HOMOGENEOUS IMMUNOASSAYS FOR MULTIPLE ALLERGENS - A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels. | 05-05-2011 |
| 20110116972 | MICROFLUIDIC ASSAYS AND MICROFLUIDIC DEVICES - The invention is a method for determining in the amount of an analyte (An) in a sample. The method comprises competitive immunoassays and enzymatic assays in which a soluble product (immune complex and enzymatic product, respectively) is formed. The product is subsequently measured in a measuring zone of a microchannel structure of a microfluidic device. | 05-19-2011 |
| 20110123399 | DEVICE FOR MEASURING PROTEINS USING BIOSENSOR - A sensor for measuring a protein with a measurement speed improved from a conventional impedance measurement, using a biosensor is provided. The sensor is capable of efficiently and accurately measuring impedance generated by a selective binding to the protein by Fourier-transforming an electric current signal which is obtained by applying a potential signal of a delta function waveform. | 05-26-2011 |
| 20110123400 | APPARATUS FOR DETECTING METAL CONCENTRATION IN AN ATMOSPHERE - The present invention provides an apparatus for detecting metal concentration from an area including compounding a solution that includes a metal dissolved by a solvent, and a reagent combined with metal ions dissolved in the solution and referring a difference of absorption rates between a compound of the solvent and reagent and a compound of the solution and reagent. | 05-26-2011 |
| 20110123401 | Detection Apparatus for Biological Materials and Methods of Making and Using the Same - Apparatus comprising a surface site comprising a substantially inorganic surface having a chemical composition selected from the group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within a polypeptide bonding region and having a selective bonding affinity for a polypeptide; a plurality of interlayers between which the surface site is interposed; a distal site end on the surface site and distanced from the interlayers, the surface being provided on the distal site end; the surface site and the interlayers being interposed between first and second supports; first and second conductors provided on the first and second supports and having respective first and second distal conductor ends positioned within the polypeptide bonding region; the conductors being capable of applying an external voltage potential across the polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising a third conductor in electrical communication with the surface site, the third conductor positioned for electrical communication with a source of an external bias voltage. Techniques for making apparatus. | 05-26-2011 |
| 20110150704 | CONTAINER HAVING GAS SCRUBBER INSERT FOR AUTOMATED CLINICAL ANALYZER - A device and method for extending the useful life of a liquid in a container used in an automated clinical analyzer. The liquid comprises a material subject to deterioration, the subject material capable of deteriorating as the result of reaction with a contaminant in a gas present in the atmospheric air surrounding the container. Atmospheric air surrounding the container that displaces the liquid consumed from a container is routed through a gas scrubber insert in order to remove or at least reduce the quantity of at least one contaminant present in that air. The gas scrubber insert is positioned between the liquid in the container and the atmospheric air surrounding the container. The gas scrubber insert contains a reagent that is capable of reacting with a contaminant in the atmospheric air surrounding the container, whereby a required characteristic(s) of the liquid does (do) not change excessively prior to the date that the liquid is consumed. For example, if the contaminant is carbon dioxide, and the required characteristic of the liquid is the level of pH of the liquid, the reagent in the gas scrubber insert prevents the level of pH of the liquid from changing excessively prior to the date that the liquid is consumed. | 06-23-2011 |
| 20110158852 | OFFSET PATH MIXERS AND FLUID SYSTEMS INCLUDNG THE SAME - Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include one or more channels that provide a fluid path through a body, wherein fluid flowing through each channel defines a downstream direction through the channel. The channel includes two or more sets of concatenated mixing elements arranged adjacent to each other across the width of the channel, wherein two sets of the mixing elements are offset from each other along the downstream direction of the channel. | 06-30-2011 |
| 20110165024 | DEVICES AND METHODS FOR DETECTING ANALYTES IN FLUID SAMPLES - A device for detecting the presence or amount of an analyte in a fluid sample and method thereof, comprises a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample, and has a first position and a second, locked position within the receiving cup. The absorbent member is uncompressed in the first position and is compressed in the second, locked position. The sample collector or the receiving cup has at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample. | 07-07-2011 |
| 20110176965 | Y-CROSS MIXERS AND FLUID SYSTEMS INCLUDING THE SAME - Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include a mixing structure formed within a body, wherein fluid flowing through the mixing structure defines a downstream direction through the mixing structure. The mixing structure includes a series of Y-shaped channels that cross to provide flowpaths that result in efficient mixing. | 07-21-2011 |
| 20110194978 | MICROFLUIDIC DEVICE - It is a microfluidic device including a flowchannel in which liquid flows. The flowchannel includes a main channel and a pair of branch channels provided across the main channel from each other to be each connected to the main channel. The main channel includes a first zone, a second zone, and a coupling zone that connects the first zone and the second zone. The second zone is smaller than the first zone in a distance between a bottom surface and a ceiling surface. The coupling zone is configured such that the distance between the bottom surface and the ceiling surface thereof gradually decreases towards the second zone from the first zone. A connection zone provided in the main channel and connected to each of the pair of branch channels overlaps with the coupling zone. | 08-11-2011 |
| 20110194979 | Modulated magnetic permeability sensing assays - An analyte detection system includes a detector situated close to a well of a substrate. The well includes conjugated paramagnetic beads. The detection system also includes a magnetic field generator that provides an oscillating magnetic field in the well and the detector, an oscillator circuit coupled to the detector, and a circuit coupled to the detector that detect the conjugated paramagnetic beads. A method includes applying a magnetic field to well of a substrate with conjugated paramagnetic beads, alternating the polarity of the magnetic field, detecting a waveform associated with the alternating magnetic field, and associating the waveform with the quantity of conjugated paramagnetic beads. An analyte detection kit includes a substrate with an attached antibody that is reactive to the analyte, a conjugated paramagnetic particle, and a conjugated paramagnetic particle detector. | 08-11-2011 |
| 20110194980 | Process For Hydrophilizing Surfaces Of Fluidic Components And Systems - A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids. | 08-11-2011 |
| 20110206560 | BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE - The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites. | 08-25-2011 |
| 20110217205 | DIAGNOSTIC RADIO FREQUENCY IDENTIFICATION SENSORS AND APPLICATIONS THEREOF - An integrated passive wireless chip diagnostic sensor system is described that can be interrogated remotely with a wireless device such as a modified cell phone incorporating multi-protocol RFID reader capabilities (such as the emerging Gen-2 standard) or Bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as thin films, MEMS, electrochemical, thermal, resistive, nano or microfluidic sensor technologies. Applications of the present invention include on-the-spot medical and self-diagnostics on smart skin patches, Point-of-Care (POC) analyses, food diagnostics, pathogen detection, disease-specific wireless biomarker detection, remote structural stresses detection and sensor networks for industrial or Homeland Security using low cost wireless devices such as modified cell phones. | 09-08-2011 |
| 20110236262 | BIOLOGICAL SUBSTANCE DETECTING APPARATUS - A biological substance detecting apparatus that enables stable detection and quantitative analysis of biologically derived target substances is provided. The biological substance detecting apparatus employs a sensor chip provided with a fine flow channel through which a sample liquid is caused to flow, and a sensor surface that adsorbs a biologically derived target substance. Light is irradiated onto the sensor surface, and light emitted by the adsorbed target substance or a labeling substance bound thereto is detected. A flow speed controlling means, for controlling the flow speed of the sample liquid that flows through the fine flow channel to a value within a range such that the adsorption speed of the target substance is not controlled by dispersion. | 09-29-2011 |
| 20110256025 | IMMUNOASSAY PRODUCT AND PROCESS - The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so. | 10-20-2011 |
| 20110262306 | Detecting apparatus with photonic crystal structure - A detecting apparatus with photonic crystal structure comprises several empty spaces arranged orderly and a molecularly imprinted polymer containing an inorganic material. The molecularly imprinted polymer has several imprinted sites for specifically binding with a target compound. The empty spaces are orderly arranged in the inner of the molecularly imprinted polymer. The empty spaces and the molecularly imprinted polymer form a photonic crystal structure. | 10-27-2011 |
| 20110286887 | OPEN TYPE GROOVE CHANNEL CHIP - The present invention relates to an open-type groove channel chip. More particularly, the present invention relates to an open-type groove channel chip comprising a main body upper plate ( | 11-24-2011 |
| 20110305599 | OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER - The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer. | 12-15-2011 |
| 20110318228 | METHODS AND DEVICE FOR THE DETECTION OF OCCULT BLOOD - The present invention relates generally to detection of occult blood. In particular, the present invention provides a device and methods for the simultaneous detection of hemoglobin and transferrin in fecal samples, which permit a more sensitive diagnosis of occult blood in fecal sample and a differential diagnosis of bleeding of the upper GI tract versus the lower GI tract. | 12-29-2011 |
| 20120014836 | MANIPULATION OF MAGNETIC PARTICLES IN A BIOLOGICAL SAMPLE - The present invention relates to a microfluidic device, to be used with a processing device comprising a magnetic supplier, the microfluidic device comprising: —a chamber arranged to receive a biological sample and to comprise at least one magnetic particle, and—storing means for storing information comprising a magnetic protocol in a form readable by the processing device, wherein the magnetic supplier being able to generate magnetic forces on the magnetic particle(s) according to this magnetic protocol read from the storing means. The invention relates also the said processing device and to a system comprising said microfluidic device and said processing device, as well as a method of manipulating the magnetic particles according to said magnetic protocol. | 01-19-2012 |
| 20120020836 | PIPETTING NOZZLE FOR AUTOANALYZER, METHOD FOR PRODUCING SAME AND AUTOANALYZER USING SAME - In an autoanalyzer for analyzing samples, such as urine and blood, analytical and measured values are prevented from being affected by carry-over caused by the repeated use of a pipetting nozzle. A molecular layer for inhibiting the adsorption of biological polymers is formed by coating surfaces of the pipetting nozzle with a polyethylene glycol derivative chemisorbed thereto, thereby reducing carry-over caused by the pipetting nozzle. | 01-26-2012 |
| 20120020837 | Portable Apparatus for Improved Sample Analysis - The present invention is an improved apparatus for sample analysis. The apparatus employs an assay component containing a membrane having one or a plurality of analyte-specific binding agents attached thereto, a means for absorbing liquid, and a piston means for drawing analytes through said membrane into said means for absorbing liquid. The apparatus is configured to be portable and provide a detector for detecting binding of an analyte to an analyte-specific binding agent, a plurality of data acquisition components, and a computer for integrating, analyzing and storing the detected analyte specific binding and acquired data. | 01-26-2012 |
| 20120045368 | Chemical Coating of Microwell for Electrochemical Detection Device - The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical. | 02-23-2012 |
| 20120063955 | METAL-ENHANCED FLUORESCENCE FROM PLASTIC SUBSTRATES - The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an activated polymeric surface for deposition of metallic particles to form a fluorescence sensing device. The device can be used for metal-enhanced fluorescence of fluorophores positioned above the metallic particles that can be readily applied to diagnostic or sensing applications of metal-enhanced fluorescence. | 03-15-2012 |
| 20120076694 | Analyte Detection Using an Active Assay - Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types. | 03-29-2012 |
| 20120087831 | RAPID DIAGNOSTIC DEVICE, ASSAY AND MULTIFUNCTIONAL BUFFER - A rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit for receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The delivery unit comprises a label zone permeated with a dried indicator reagent which can be placed in transient fluid communication with the reaction zone of the test unit during the assay procedure. The rapid diagnostic assay system reduces the number of assay reagents, method steps and time required for performance compared to other conventional assays. | 04-12-2012 |
| 20120107176 | Detection Apparatus for Biological Materials and Methods of Making and Using the Same - Apparatus comprising surface site comprising substantially inorganic surface having chemical composition selected from group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within polypeptide bonding region and having selective bonding affinity for polypeptide; plurality of interlayers between which surface site is interposed; distal site end on surface site and distanced from interlayers, the surface being provided on distal site end; surface site and interlayers being interposed between first and second supports; first and second conductors provided on first and second supports and having respective first and second distal conductor ends positioned within polypeptide bonding region; conductors being capable of applying external voltage potential across polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising third conductor in electrical communication with surface site, the third conductor positioned for electrical communication with source of an external bias voltage. Techniques for making apparatus. | 05-03-2012 |
| 20120107177 | CLICK CHEMISTRY SURFACE FUNCTIONALIZATION FOR RESONANT MICRO-CAVITY SENSORS - Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element. | 05-03-2012 |
| 20120128535 | Bridged Element For Detection Of A Target Substance - Physical changes resulting from an association between a template molecule and a target molecule are detected by monitoring changes in the template molecule. Exemplary changes include a change in a physical dimension or stiffness of the template molecule, a change in electrical conductivity of the template molecule and a change in the energy required to dissociate the target molecule and the template molecule. The magnitude of the change is indicative of the specific identity of the target molecule. | 05-24-2012 |
| 20120128536 | MOLECULARLY PRINTED POLYMER FOR DETECTING THE PENTRAXIN, AND METHOD FOR PREPARING SAME - The present disclosure relates to a molecularly imprinted structure for detection of a pentraxin protein and a method for preparing the same by synthesizing a reactive group-pentraxin protein ligand complex specifically reacting with the pentraxin protein and being polymerizable with a crosslink agent to detect a pentraxin protein by using the complex. The present disclosure also provides a chip for detection of a C-reactive protein and a method for preparing the same, the chip including a molecularly imprinted layer having excellent sensitivity to a C-reactive protein and an improved binding force to a metal substrate by using click chemistry. | 05-24-2012 |
| 20120141327 | LABEL-FREE BIOSENSOR - A label-free biosensor includes a substrate, a reaction inducing part for inducing a bio antigen-antibody reaction to occur, and a reaction detecting part formed on the substrate and adapted to measure current change in accordance with change in an amount of light, which is caused by the bio antigen-antibody reaction in the reaction inducing part, to detect a bio antigen. | 06-07-2012 |
| 20120148448 | MICROFLUIDIC-CHANNEL EMBEDDABLE, LATERALLY OSCILLATING GRAVIMETRIC SENSOR DEVICE FABRICATED WITH MICRO-ELECTRO-MECHANICAL SYSTEMS (MEMS) TECHNOLOGY - Laterally oscillating gravimetric sensing device embeddable under micro-fluidic channels and fabricated with micro-electro mechanical systems (MEMS) technology, which detects biological cells and analytes by measuring the change of mass attached on its surface is composed of four main groups, namely a resonator that can be placed onto the basis of the channel, components of the resonator bio-activation, a micro fluidic channel, and the microfabrication techniques, and its main components are the proof mass ( | 06-14-2012 |
| 20120164027 | Polymer Based Lanthanide Luminescent Sensors for the Detection of Organophosphorus Compounds - A device for measuring and detecting the organophosphorus compounds, such as a pesticides or a nerve agents is provided. The devices function by selectively binding an organophosphorous compound to a luminescent functionality-imprinted copolymer. The copolymers possess a securely bound luminescent lanthanide ion, such as Eu | 06-28-2012 |
| 20120164028 | LATERAL FLOW ASSAY TEST STRIP AND METHOD OF MAKING THE SAME - The invention relates to a lateral flow assay test strip and a method for making the same. The strip comprises, in the flow direction, a selectively activated membrane for a test reaction and an absorption pad, which are both made of paper and may comprise an integral paper strip. The absorption pad has the paper strip embossed and/or folded to increase the strip's absorption capacity. The folded pad may have an accordion-like configuration, the strip running to-and-fro, or it may have the strip rolled and then flattened to a stack of layers. | 06-28-2012 |
| 20120177537 | APPARATUS AND METHOD FOR SEPARATING PLASMA - An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer. | 07-12-2012 |
| 20120183439 | CHEMICAL ANALYZER - A chemical analyzer has a reaction vessel magazine | 07-19-2012 |
| 20120183440 | FRET MEASUREMENT METHOD AND DEVICE - Among donor molecules labeling protein in living cells to be measured, the rate of donor molecules binding to an acceptor molecule and occurring FRET is determined. In a plurality of previous measurement samples having different ratios of first molecule concentration to second molecule concentration, a fluorescence lifetime of the first molecule are calculated and the fluorescence lifetime minimum value of the first molecule is calculated. The samples are irradiated with a laser beam having time-modulated intensity and the fluorescence emitted by the laser-irradiated measurement samples are measured. By using the fluorescent signals thus measured, the fluorescence lifetime of the first molecule is calculated. By using the fluorescence lifetime minimum value of the first molecule and the fluorescence lifetime of the first molecule that is calculated above, the rate of the first molecules occurring FRET in the first molecules in the measurement samples is calculated. | 07-19-2012 |
| 20120195797 | MEMS Sensors with Closed Nodal Anchors for Operation in an In-Plane Contour Mode - A MEMS sensor includes at least one closed nodal anchor along a predetermined closed nodal path on at least one surface of a resonant mass. The resonant mass may be configured to resonate substantially in an in-plane contour mode. Drive and/or sense electrodes may be disposed within a cavity formed at least in part by the resonant mass, the closed nodal anchor, and a substrate. | 08-02-2012 |
| 20120195798 | PIPETTE TIP SUPPLYING APPARATUS, SAMPLE ANALYZER AND PIPETTE TIP SUPPLYING METHOD - The present invention is a pipette tip supplying apparatus which comprises: a storing section configured to store a plurality of pipette tips; a supplying section configured to supply at least one of the plurality of pipette tips stored in the storing section outside the storing section; a detector configured to detect a pipette tip assembly in which one pipette tip and another pipette tip are piled up with a distal end of the one pipette tip inserted into the another pipette tip; and a discharging section configured to discharge the pipette tip assembly from the storing section, when the detector has detected the pipette tip assembly in the storing section. | 08-02-2012 |
| 20120201716 | SURFACE PLASMON-ENHANCED FLUORESCENCE MEASURING APPARATUS - Provided is an apparatus having a beam geometry changing device that changes the beam geometry of excitation light, and a control device that controls the beam geometry changing device, with favorable precision, which the apparatus performs a resonance angle scan and to detect a target material. | 08-09-2012 |
| 20120213669 | OPTICAL-WAVEGUIDE SENSOR CHIP, METHOD OF MANUFACTURING THE SAME, METHOD OF MEASURING SUBSTANCE, SUBSTANCE-MEASURING KIT AND OPTICAL-WAVEGUIDE SENSOR - An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance. | 08-23-2012 |
| 20120213670 | DEVICE TO DETECT ANALYTES IN A BIOLOGICAL SAMPLE - Device to detect at least an analyte, comprising a transparent substrate ( | 08-23-2012 |
| 20120219458 | SENSING DEVICE - A sensing device is configured that a first piezoelectric vibrator and a second piezoelectric vibrator, changing over a connection to an oscillation circuit, have the oscillation circuit in common, that an impedance of a conductive path including a first one-surface-side electrode constituting the first piezoelectric vibrator from the oscillation circuit and an impedance of a conductive path including a second one-surface-side electrode constituting the second piezoelectric vibrator from the oscillation circuit are uniform with each other, and that an impedance of a conductive path including a first other-surface-side electrode constituting the first piezoelectric vibrator from the oscillation circuit and an impedance of a conductive path including a second other-surface-side electrode constituting the second piezoelectric vibrator from the oscillation circuit are uniform with each other. | 08-30-2012 |
| 20120244037 | SENSING DEVICE AND BIOSENSOR - Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor | 09-27-2012 |
| 20120251392 | Biosensor Using Magnetic Microparticles - Provided is a biosensor using magnetic microparticles whereby a biomaterial can be detected at a high sensitivity. The biosensor using magnetic microparticles is provided with a light source ( | 10-04-2012 |
| 20120251393 | DISPENSING NOZZLE FOR AUTOMATIC ANALYZER, AND AUTOMATIC ANALYZER INCLUDING SAME - An automatic analyzer for analyzing samples, such as urine and blood, is adapted so that analysis measured values are not affected by carry over by a repeatedly used dispensing nozzle. Coating the surface of the dispensing nozzle with a chemisorbed polyethylene glycol derivative forms a molecular layer that inhibits the adsorption of biopolymers, to reduce carry over by the dispensing nozzle. | 10-04-2012 |
| 20120288408 | SAMPLE ANALYSIS DISC AND METHOD OF PRODUCING SAMPLE ANALYSIS DISC - A sample analysis disc has concave sections and convex sections formed alternately in a track area of a disc surface. Labeled beads are immobilized to the track area. Each labeled bead has a biopolymer bound thereto. Only one of the labeled beads is allowed to be filled in each concave section. | 11-15-2012 |
| 20120315189 | Immunoassay Product And Process - The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so. | 12-13-2012 |
| 20120321517 | Sensor Apparatus and Method using Optical Interferometry - A sensor includes a sensor head with at least two surfaces separated by a gap. One surface is mechanically fixed, a second surface is free to move and deflections of the second surface relative to the first surface are monitored by optical interferometry. An optical fiber could be used to direct light from a light source to the sensor and collect light reflected by the sensor. Interaction of molecules or other objects in the sample with the second surface is detected as a change in amplitude and/or phase of deflection the second surface in response to an applied driving signal. A layer of binding molecules may be immobilized on the second surface and this surface exposed to a sample. | 12-20-2012 |
| 20120321518 | Assay Devices and Methods for the Detection of Analytes - The present invention relates to devices and methods for performing assays, especially for determining the presence and/or amount of one or more analytes. In particular, the invention relates to a device for the detection of analytes, comprising a reversibly compressible matrix located between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and wherein the distance between the first surface and the second surface is variable. The invention also relates to a corresponding method using such a device for the detection of one or more species of analytes. | 12-20-2012 |
| 20130004370 | QUANTITATIVE SENSOR AND MANUFACTURING METHOD THEREOF - A quantitative sensor and manufacture method thereof are disclosed. This quantitative sensor has a dual-mode film bulk acoustic resonator structure to achieve desirable performances in sensitivity, accuracy and efficiency. Furthermore, this quantitative sensor serves as a fluid sensor when a fluid detection metal layer is formed in a sample-receiving chamber; and this quantitative sensor may also serve as a bio sensor when biocompatible metal layer and a bio-sensing layer are formed in the sample-receiving chamber instead of the fluid detection metal layer. | 01-03-2013 |
| 20130004371 | Analytical Cartridge with Fluid Flow Control - Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample. | 01-03-2013 |
| 20130052081 | DETECTION SYSTEM FOR HIGH SENSITIVITY FLUORESCENT ASSAYS - This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels. | 02-28-2013 |
| 20130052082 | ANALYSIS SYSTEM FOR ANALYZING A SAMPLE ON A TEST ELEMENT - The invention relates to an analysis system for analyzing a sample on a test element. The system has an analysis unit for generating a signal as a function of an analyte contained in a sample, and a detection unit for detecting the signal. The analysis system further includes a test element holder into which the test element can be reversibly introduced and in which it can be positioned relative to the analysis unit and the detection unit. The test element contains at least one guide element, which is suitable for laterally guiding the test element, so that the test element in the test element holder is held and guided only on an outer region of the test element, and an inner region of the test element introduced into the test element holder remains free. The test element contains a sample application site in the inner region. | 02-28-2013 |
| 20130058829 | CELLS FOR BIOCHEMICAL ANALYSIS, KIT FOR BIOCHEMICAL ANALYSIS, AND BIOCHEMICAL ANALYZER - The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum. | 03-07-2013 |
| 20130064713 | BONDING AGENT AND DEVICE FOR USE IN MICROFLUIDICS - Disclosed embodiments concern a microfluidic device comprising a bonding agent and two or more components. In particular disclosed embodiments, the microfluidic device is made out of the disclosed bonding agent. Also disclosed are embodiments of a method for making a microfluidic device, wherein the method includes using the disclosed bonding agent to couple two or more components together. | 03-14-2013 |
| 20130064714 | CHIP FOR FLUID ANALYSIS - Disclosed herein is a chip for analyzing fluids which restricts the flow of a fluid and the flow velocity of the fluid at a reaction unit, where an antigen-antibody reaction occurs, to increase reactivity and sensitivity. | 03-14-2013 |
| 20130071289 | Biosensor on Thin-Film Transistors - The present invention relates to sensors, in particular, biosensors based on organic thin-film transistors. | 03-21-2013 |
| 20130078145 | SEMICONDUCTOR-BASED DETECTION AND DECONTAMINATION SYSTEM - A system for identifying and making quantitative determinations with respect to deposits on a portion of the system, determining that the deposit is a contaminant, and decontaminating at least the portion of the system is described. The system uses an embedded controller. It further includes an embedded sensing portion monitoring an atmosphere above the sensing portion. The sensing portion communicates with at least said controller and detects a quantity of the deposits. The sensing portion can be a film layer on a surface. The system also includes an embedded self-decontaminating portion. | 03-28-2013 |
| 20130078146 | SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS DEVICE AND SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS METHOD - A surface plasmon resonance fluorescence analysis device emits a light beam to a prism in which a metal film is formed on a prescribed surface while changing an angle of incidence relative to the metal film in a state in which the light beam is totally reflected, measures light generated on a surface of the metal film, determines an angle at which the light beam enters the metal film based on a change in intensity of the measured light, adjusts the emitting direction of the light beam so that the light beam enters the metal film at the determined angle of incidence, and measures fluorescence generated on the surface of the metal film in a state in which the light beam is emitted the adjusted direction. | 03-28-2013 |
| 20130078147 | LIQUID-TRANSPORT AND ANALYTICAL TEST DEVICE - A liquid-transport device has a liquid-tight support ( | 03-28-2013 |
| 20130078148 | NEAR FIELD-ENHANCED FLUORESCENCE SENSOR CHIP - A surface plasmon-field enhanced fluorescence spectroscopy [SPFS] sensor chip may include a transparent support, a metal thin film formed on one surface of the transparent support, a self-assembled monolayer [SAM] formed on a surface of the metal thin film, said surface not being in contact with the transparent support, a solid phase layer formed on a surface of the SAM and having a three-dimensional structure, said surface not being in contact with the metal thin film, and a ligand immobilized in the solid phase layer. A fluctuation ratio represented by the following formula is not less than 0% but not more than 30%: | 03-28-2013 |
| 20130089465 | MICROMECHANICAL SENSOR SYSTEM HAVING SUPER HYDROPHOBIC SURFACES - A sensor system is provided to detect the mass of a compound in a liquid solution, the system including a sensor including a plurality of pillars extending from a substrate and having a given height, the pillars having a free end opposite to the substrate, and including a lateral surface connecting said free end to the substrate. The free end defining a surface and the surface is functionalized in order to bind with the compound to be detected, and the lateral surface is hydrophobic. The distance between any two nearest neighbors pillars of the plurality satisfies the following equation | 04-11-2013 |
| 20130089466 | Chemical Coating of Microwell for Electrochemical Detection Device - The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical. | 04-11-2013 |
| 20130089467 | GENERATION DEVICE, GENERATION METHOD, ANTIBODY CHIP, COMPUTER PROGRAM AND NON-TRANSITORY COMPUTER-READABLE MEDIUM - A generation device and the like for generating long-life antibody chips which can be produced and held in stock is a generation device and the like for generating an antibody chip by binding antibody to a cup, including an antibody solution holder that holds antibody solution having antibody, a buffer solution holder that holds buffer solution, and an injector that injects solution into the cup. The injector has an inlet out of which solution is injected. The injector injects the buffer solution held by the buffer solution holder. The injector injects the antibody solution held by the antibody solution holder with the inlet in the buffer solution in the cup. | 04-11-2013 |
| 20130115135 | CENTRIFUGAL-BASED MICROFLUIDIC APPARATUS, METHOD OF FABRICATING THE SAME, AND METHOD OF TESTING SAMPLES USING THE MICROFLUIDIC APPARATUS - Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test. | 05-09-2013 |
| 20130121879 | Magnetic-Field Measurement Device - The disclosed magnetic immunoassay device, which performs magnetic immunoassays using antigen-antibody reactions, can perform speedy immunoassays without bound/free separation in the test samples. The device is also practical, being capable of stable magnetism measurement without magnetic shielding. The disclosed magnetic immunoassay device is provided with: an excitation coil that uses an AC magnetic field to magnetize a test sample containing a magnetic marker; a magnetism sensor that measures magnetism in the test sample and outputs a magnetism signal; and a displacement sensor for detecting changes in the distance between the test sample and the magnetism sensor. By optimally setting the bandwidth of a lock-in amplifier, which detects changes in the phase of the magnetism signal outputted by the magnetism sensor, and the rotational speed produced by a drive system, which moves the test sample at low speeds, the impact of environment magnetic noise is reduced, and correcting the magnetism signal using distance information obtained from the displacement sensor allows stable magnetism measurement. | 05-16-2013 |
| 20130149196 | Method for Functionalising Fluid Lines Contained in a Micromechanical Device, Micromechanical Device Including Functionalised Lines, and Method for Manufacturing Same - The present invention relates to a method for functionalising fluid lines ( | 06-13-2013 |
| 20130156643 | DEVICE AND METHOD FOR MANIPULATING OR ANALYSING A LIQUID SAMPLE - A device and a method for manipulating or analysing a liquid sample in a microfluidic channel are proposed. In order to implement an immunoassay, a movable substrate having a binding region is inserted in the channel. The substrate is embodied as a plate-like plastic part and is microstructured in the binding region. It is magnetically movable in the channel and for optical detection can be moved into a gas space. | 06-20-2013 |
| 20130156644 | INTEGRATED MICROFLUIDIC CARTRIDGE - Embodiments of the disclosure describe a structure for mounting a biosensor in a microfluidic cartridge including a biosensor holder, a gasket seal, a strut, and a leaf spring using a method for maintaining constant pressure and a microfluidic cartridge including the same. The structure allows pressure to be evenly distributed to the biosensor in order to secure reproducibility and reliability of the detection signal, and enables integrated configuration of the cartridge by using a minimum amount of space. | 06-20-2013 |
| 20130156645 | C-REACTIVE PROTEIN IMPRINTED POLYMER FILM AND MICROCHIP SYSTEM UTILIZING THE SAME - The present invention is a C-reactive protein imprinted polymer film. The C-reactive protein antibody imprinted polymer film comprises a plurality of imprinted nanocavities with unified orientation and distribution formed by removing a plurality of C-reactive proteins from a polymer film. Its ability to capture the target proteins can achieve 99% compared with the natural antibodies. The present invention further provides a C-reactive protein microchip system formed by the dynamic capacitance sensing method with the above imprinted polymer film. The C-reactive protein microchip system comprises a body having a first chamber and a second chamber, and a detector. | 06-20-2013 |
| 20130171026 | POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE - A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A) | 07-04-2013 |
| 20130171027 | OXYGEN SENSORS BASED ON HARD-SOFT ACID-BASE RELATIONSHIPS - A fluorescence quenching oxygen sensor ( | 07-04-2013 |
| 20130177479 | COMPONENT MEASUREMENT DEVICE - A component measurement device, namely a blood-glucose measurement device, that has a measurement unit that focuses measurement light on a test paper through an illumination lens and receives reflected light from the test paper. The blood-glucose measurement device measures blood components on the basis of results from detecting the reflected light. The illumination lens is provided in the measurement unit such that the focal point of the measurement light is beyond the test paper. | 07-11-2013 |
| 20130195721 | METALLIC-NANOFINGER DEVICE FOR CHEMICAL SENSING - A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided. | 08-01-2013 |
| 20130202488 | OPTICAL EVANESCENT FIELD SENSOR - The invention relates to an optical sensor device ( | 08-08-2013 |
| 20130224073 | Device for detection of magnetic nanoparticle aggregation or disaggregation - A device that uses radiofrequency detection of the aggregation or disaggregation of magnetic nanoparticles without using nuclear magnetic resonance methods is described. The signals from one or more magnetic nanoparticle species in separate sample wells are compared to ascertain that aggregation or disaggregation has occurred. Depending on the specific reagents used, the detected aggregation or disaggregation event can be interpreted as an indicator of the presence of a molecule or microorganism of interest in a liquid sample. | 08-29-2013 |
| 20130224074 | CHROMATOGRAPHIC MEASUREMENT APPARATUS - Higher economic efficiency is ensured in a chromatographic measurement even when a chromatographic measurement apparatus is used at a place with risk of contamination of testing equipment. A chromatographic measurement apparatus includes an apparatus main body and a measurement unit, wherein the apparatus main body and the measurement unit are configured to be capable of wireless communication of a signal representing measurement information obtained by the measurement unit and capable of mutual pairing setting. The apparatus main body includes a storage section for storing the measurement information, an extracting section for extracting, from a signal obtained via wireless communication, a signal from the measurement unit paired with the apparatus main body based on the pairing setting, and a display section for displaying the measurement information. | 08-29-2013 |
| 20130230427 | METHOD FOR FABRICATING A BIOSENSOR CHIP AND THE BIOSENSOR CHIP MADE THEREBY - A method of fabricating a biosensor chip includes: forming at least one metallic layer on a transparent substrate to form a composite member; disposing the composite member in a vacuumed chamber, and introducing a gas into the vacuumed chamber; applying microwave energy to the gas to produce a microwave plasma of the gas within the vacuumed chamber, and causing the microwave plasma to interact with the metallic layer so that the metallic layer is melted and formed into a plurality of metallic nanoparticles that are spaced apart from each other and that expose partially the surface of the transparent substrate; and disposing a receptor at the surface of the transparent substrate that is exposed among the metallic nanoparticles. A biosensor chip is also disclosed. | 09-05-2013 |
| 20130259747 | Optical Biosensor - An optical biosensor includes a sensing block that receives a first optical signal and outputs a second optical signal through at least one channel of a plurality of channels that correspond to a sensed concentration of a biomaterial; and a detecting block that detects the second optical signal, converts the second optical signal into an electrical signal, and outputs the electrical signal. | 10-03-2013 |
| 20130266479 | Microfluidic Separation Device - A microfluidic separation device is provided that includes a first sample channel region and a second sample channel region, where the first sample channel region has an array of channels that are smaller than the second channel region, a first detection region and a second detection region located at the interface of the first sample channel region, a detection channel, an illuminating electric field, Raman-scattering nanoparticles having surface plasmon resonances for detection when illuminated by the electric field, where the resonances create an enhanced local electric field along specific directions resulting in an enhanced Raman response, and a nanoparticle input channel disposed to input the nanoparticles into the second sample channel region, where the nanoparticles are larger than the cross-section of the first sample channel region and the cross-section of the second detection region, where the nanoparticles collect in the first detection region to form region of densely packed nanoparticles. | 10-10-2013 |
| 20130266480 | ASSAY CHIP - An assay chip includes fluidic-channel member composed of a light-transmissive lower member and an upper member, forming a fluidic-channel therebetween, and a cover member fitted with the fluidic-channel member from the upper-member-side thereof. An inlet for injecting a sample solution into the fluidic-channel and a suction opening for sucking, from the downstream side, the injected sample solution, both communicating with the fluidic-channel, are formed on the upper surface of the upper member. A pot for carrying out predetermined pre-processing on the sample solution, a pot for first-reaction processing to bind a photoresponsive labeling substance to an analyte in the sample solution, an inlet insertion-hole for inserting the inlet, and a suction-opening insertion-hole for inserting the suction opening are linearly arranged on the upper surface of the cover member. | 10-10-2013 |
| 20130287631 | MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION - Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods. | 10-31-2013 |
| 20130294972 | ZERO-MODE WAVEGUIDE FOR SINGLE BIOMOLECULE FLUORESCENCE IMAGING - The disclosed subject matter provides a zero-mode waveguide (ZMW) including a substrate and at least one nano-well thereon and having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nano-well can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the ZMW are also provided. | 11-07-2013 |
| 20130309134 | PORTABLE DETECTION SYSTEM FOR ALLERGIC DISEASES - A portable detection system for allergic diseases includes a filtration-based inspection module and a reader module. The filtration-based inspection module includes an FPW sensor and a liquid sample filtration apparatus, wherein the liquid sample filtration apparatus includes an injection opening, a passage module, a filtering membrane and a gathering aperture. The injection opening is in communication with the gathering aperture. The FPW sensor comprises a frame body, a carrier and a sensing chip having an accommodating slot in communication with the gathering aperture. The carrier comprises a plurality of conductive terminals, and the conductive terminals are electrically connected with the sensing chip. The reader module comprises a connection slot capable of being inserted by the conductive terminals of the carrier. | 11-21-2013 |
| 20130309135 | OPTICAL BIOSENSOR, BIO-SENSING SYSTEM INCLUDING THE SAME, AND METHOD OF FABRICATING THE OPTICAL BIOSENSOR - An optical biosensor including a bio-sensing unit configured to receive an optical signal and generating a sensed optical signal, the wavelength of which varies according to a result of sensing a biomaterial; and a spectrometer including a plurality of ring resonators for dividing the sensed optical signal according to a wavelength and generating a plurality of output optical signals, respectively. | 11-21-2013 |
| 20130315782 | Biochip and fabrication thereof - A biochip comprising a plastic substrate, an IC chip, and a sealing cover is disclosed in this invention. The plastic substrate combines the function of sample inlet area, separating structure, micro-fluidic channel, flow resistor, detection area, and capillary pump or suction area. Sealing the plastic substrate with porous cover could make the structure of micro-fluidic to form the capillary effect or degas-driven effect, and drive the sample naturally without extra pump. The detection area is constituted by the IC chip which is embedded into the plastic substrate, and the IC chip includes the amplifier circuit and detection structure. In the detection area, there uses the biological specific conjugates to catch the bio-particles, nano-particles, or macromolecule sensitively. And finally, transfer the detected electric signal to a mobile communication device. | 11-28-2013 |
| 20130315783 | SENSOR - A device for detecting an analyte in a sample, which includes a radiation source adapted to generate electromagnetic radiation; a transducer capable of transducing a change in energy to an electrical signal; at least one tethered reagent on or proximal to the transducer, the tethered reagent having a binding site which is capable of binding the analyte; a chamber for holding the sample in fluid contact with transducer, wherein the chamber is adapted to contain the sample on inversion, partial inversion or agitation of the device; and a detector which is capable of detecting the electrical signal generated by the transducer. | 11-28-2013 |
| 20130315784 | CELLS FOR BIOCHEMICAL ANALYSIS, KIT FOR BIOCHEMICAL ANALYSIS, AND BIOCHEMICAL ANALYZER - The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum. | 11-28-2013 |
| 20130330230 | OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES - A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries. | 12-12-2013 |
| 20140004000 | LEAD-FREE PIEZOELECTRIC CERAMIC FILMS AND A METHOD FOR MAKING THEREOF | 01-02-2014 |
| 20140010712 | APPARATUS FOR DETECTING A SELECTED LIQUID CONTAMINANT - An apparatus for detecting a selected liquid contaminant includes a material holder and a reactive material held by the material holder. The reactive material absorbs a selected liquid contaminant with a measurable change reaction occurring as a result of such absorption. A signal generator is provided for generating a signal upon the measurable change reaction exceeding a preset threshold. | 01-09-2014 |
| 20140017124 | FLUID ANALYSIS CARTRIDGE - A fluid analysis cartridge and a method for manufacturing the same are provided. The fluid analysis cartridge includes an inspection unit configured to receive and inspect the fluid sample, a housing comprising at least one supply hole that is configured to supply the fluid sample to the inspection unit, and a filtering unit disposed between the supply hole of the housing and the inspection unit and configured to filter a specific substance present in the fluid sample. | 01-16-2014 |
| 20140017125 | SPR SENSOR CELL AND SPR SENSOR - Provided are an SPR sensor cell having very excellent detection sensitivity and an SPR sensor. The SPR sensor cell includes: a detection unit; and a sample mounting portion adjacent to the detection unit. The detection unit includes an under clad layer, a core layer provided so that at least a part thereof is adjacent to the under clad layer, and a metal layer covering the core layer. The core layer contains 35 wt % or more of a halogen. | 01-16-2014 |
| 20140017126 | SPR SENSOR CELL AND SPR SENSOR - Provided are an SPR sensor cell having very excellent detection sensitivity and an SPR sensor. The SPR sensor cell includes a detection unit and a sample mounting portion adjacent to the detection unit. The detection unit includes an under clad layer, a core layer provided so that at least a part thereof is adjacent to the under clad layer, and a metal layer covering the core layer. The core layer has a refractive index of 1.43 or less and an absorption coefficient of 9.5×10 | 01-16-2014 |
| 20140030150 | FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS - A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker. Particular devices include multiple waveguides in multiple microfluidic channels. Particular devices include microfluidic channels with serpentine bump structures that aid molecular transport. | 01-30-2014 |
| 20140030151 | ANALYSIS DEVICE - An analysis device for performing analysis about a substance by using an analysis chip having therein a reaction area that reacts with the substance is provided. The analysis device includes: a control section in contact with the analysis chip; a first sensor for measuring an ambient temperature of the analysis chip; a second sensor for measuring the temperature at a contact area of the control section in contact with the analysis chip, and a control circuit for performing feedback control of the control section by finding a temperature of the contact area for achieving a desired temperature of the reaction area based on the ambient temperature measured by the first sensor and a temperature gradient between a position at which the ambient temperature is measured and the reaction area, setting the found temperature as a target value and setting the temperature detected by the second sensor as an output value. | 01-30-2014 |
| 20140050621 | BIOSENSOR AND BIOMATERIAL DETECTION APPARATUS INCLUDING THE SAME - Provided are a biosensor and a biomaterial detection apparatus including the same. The biomaterial detection apparatus comprises a light source to provide quantized photons; a substrate spaced apart from the light source; a single photonic sensor layer disposed on the substrate to sense the photons; and an adsorption layer disposed to cover the single photonic sensor layer, allow the photons to pass therethrough, and adsorb a biomaterial between the light source and the substrate. | 02-20-2014 |
| 20140079592 | BIO-NANOWIRE DEVICE AND METHOD OF FABRICATING THE SAME - A bio-nanowire device includes a substrate having a first surface, a first conductor, a second conductor, and a bio-nanowire. The first and second conductors are disposed on the first surface of the substrate, and are spaced apart from each other. The bio-nanowire has two ends respectively connected to the first and second conductors, and includes a nucleic acid molecule having two nucleotide segments, and a plurality of metal ions bonded between the two nucleotide segments of the nucleic acid molecule. The two nucleotide segments form a double helix structure via base pairs. When a voltage or a current is applied to the bio-nanowire, the oxidation state of the metal ions can be changed such that the non-linear electroconductive characteristic of the bio-nanowire can be controlled. | 03-20-2014 |
| 20140093427 | ASSAY DEVICE FOR LIQUID SAMPLE - Disclosed is an assay device comprising liquid transport means adapted to take up a liquid sample and conduct the liquid to an analyte detection region operable to provide a test signal indicative of the presence and/or amount of an analyte in the liquid sample; the assay device further comprising a sample presence signal generation means, which is not generated by means of immunoreaction. This sample presence signal generation means can comprise a coloured portion, which is overlaid by a material (e.g. nitrocellulose) that is opaque, when dry, and translucent or transparent, when wet, to allow the coloured portion to become visible to the user. In another embodiment the signal generation means comprises a colour changing material which under-goes a change in its visible properties upon wetting (eg. pH indication). A third embodiment uses a mobilisable detectable which, when wetted by the sample, is carried along resulting in a streaked line parallel with the flow direction. | 04-03-2014 |
| 20140093428 | DEVICE AND METHOD FOR IMMUNOASSAYS - The present invention relates to a device for performing an immunoassay, the device including a) a support, b) a porous matrix, fixed on the support, the matrix including (i) a liquid sample application area, (ii) a labeling area and (iii) at least one reaction area which includes a test results display area and a verification area, said liquid sample application area labeling area and reaction area being in fluid communication; the device including, at the verification area, at least a part of the porous matrix has pores with dimensions smaller than those of the labeled particles, such that at least a proportion of the labeled particles from the labeling area is stopped at said verification area forming a symbol which is visible or displayable for a user; and a method for manufacturing the device. | 04-03-2014 |
| 20140099236 | MICROCHIP SOLUTION SENDING SYSTEM - A microchip solution sending system may include a flow passage assembly that is at least provided with a fine flow passage that is provided with a detection region including a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and a micro pump that is connected to the flow passage assembly and that is configured to send a specimen material solution that includes the specific antigen in a reciprocating manner. The specimen material solution that has been sent may pass through the detection region in a repetitive manner in the case in which the micro pump sends the specimen material solution in a reciprocating manner, | 04-10-2014 |
| 20140119995 | DEVICE FOR DETECTING AN ANALYTE - This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte. | 05-01-2014 |
| 20140134049 | Lateral Flow Assay Device for Measuring Low Quantity Sample - This invention describes a design of a lateral flow assay device that detects dried chemicals or trice volume aqueous sample solutions, applicable for detecting body fluids and dried or liquid chemicals. The dried or aqueous samples on the sample loading area will contact with a secondary aqueous solution in described manner and flow to the reaction area. This invention enables a complete lateral flow assay while the sample volume itself is too small to accomplish a complete lateral flow test. | 05-15-2014 |
| 20140147336 | IMPEDANCE BIOSENSOR FOR ELECTRICAL IMPEDANCE BIOLOGICAL SENSING AND MANUFACTURING METHOD THEREOF - An impedance biosensor for sensing concentration of a target analyte in a solution includes an insulator substrate, electrically coupled conductive trace units on the substrate, biological sensing films, and an insulator cover. Each trace unit has a first trace and a second trace, each having a sensing end portion and a connecting end portion. The biological sensing films are disposed on the sensing end portions, and have a capture layer for capturing the target analyte. The insulator cover covers the trace units and is formed with window openings that expose the sensing end portions and that cooperate with the insulator substrate to define a space for receiving the solution therein. | 05-29-2014 |
| 20140147337 | Miniaturized Integrated Micro Electro-Mechanical Systems (MEMS) Optical Sensor Array - This invention describes a method and apparatus for actuation and multiplexed sensing using an array of sensing elements. The invention can be used for label-free detection of biological and chemical agents in a robust, miniaturized package. The invention integrates photonics, CMOS electronics, and Micro/Nano system technologies and allows multi-analyte sensing in the same package. The preferred actuation method is using magnetic thin films and preferred sensing method is optical using interference means. | 05-29-2014 |
| 20140170024 | TARGET SUBSTANCE DETECTION CHIP, TARGET SUBSTANCE DETECTION PLATE, TARGET SUBSTANCE DETECTION DEVICE AND TARGET SUBSTANCE DETECTION METHOD - [Problem] To provide a target substance detection chip, a target substance detection device, and a target substance detection method, that can be manufactured easily in a small size at low costs with reduction of the number of parts involved in the detection chip constituted by an optical prism and a detection plate used for a SPR sensor and an optical waveguide mode sensor, that can detect a target substance quickly with high sensitivity, and in which an analyte liquid is easily delivered. | 06-19-2014 |
| 20140178252 | MICROFLUIDIC DEVICES AND METHODS INCLUDING POROUS POLYMER MONOLITHS - Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores. | 06-26-2014 |
| 20140186215 | SENSOR ELEMENT, DEW CONDENSATION SENSOR, HUMIDITY SENSOR, METHOD FOR DETECTING DEW CONDENSATION, AND DEW-POINT MEASUREMENT DEVICE - A dew condensation sensor is described, including a nano-composite for generating local surface plasmon resonance, a light reflecting member disposed on one side of the nano-composite, a protection layer laminated on the light reflecting member, a light source/light receiver disposed facing the nano-composite, a spectroscope (or photo-detector) for detecting the light reflected by the light source/light receiver, a controller connected to the light source/light receiver and the spectroscope (or photo-detector) and used for overall control thereof, and a display unit connected to the controller. The dew condensation sensor detects occurrence of dew condensation based on the variation in the absorption spectrum, the absorption intensity or the reflected-light intensity of the local surface plasmon resonance of the nano-composite. | 07-03-2014 |
| 20140186216 | APPARATUS AND METHOD FOR IDENTIFYING A HOOK EFFECT AND EXPANDING THE DYNAMIC RANGE IN POINT OF CARE IMMUNOASSAYS - The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample. The system may further include a processor configured to determine a presence of a hook effect in the immunoassay based on relative values of the first and second signals and optionally determine the target analyte concentration of the sample. | 07-03-2014 |
| 20140193301 | METHOD OF GENERATING A METAMATERIAL, AND A METAMATERIAL GENERATED THEREOF - A method of generating a metamater-operable in the visible-infrared range is provided. The method comprises a) depositing a layer of a conductive material on a substrate; b) forming a layer of electron beam resist on the layer of conductive material; c) patterning the layer of electron beam resist using electron beam lithography to form a patterned substrate; d) depositing a layer of a noble metal on the patterned substrate; and e) removing the resist. A metamaterial operable in the visible-infrared range comprising split-ring resonators having a least line width of about 20 nm to about 40 nm on a substrate is provided. A transparent photonic device or a sensor for chemical or biological sensing comprising the metamaterial is also provided. | 07-10-2014 |
| 20140193302 | BASE MATERIAL COMPRISING HYDROPHILIC LAYER - This invention provides a base material comprising a plastic-containing support and, on its surface, a hydrophilic layer comprising an ethylene glycol chain (an EG chain) composed of one or more ethylene glycol units, as well as a method for producing such base material. A polysiloxane-containing primer layer is provided on the support comprising a plastic material on its surface, and the EG chain is covalently bound to a polysiloxane side chain of the primer layer. Thus, a hydrophilic layer comprising the EG chain can be provided on the surface of the plastic-containing support. | 07-10-2014 |
| 20140205503 | FRAZIL ICE CONJUGATE ASSAY DEVICE AND METHOD - An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device. | 07-24-2014 |
| 20140219869 | SUPPORT FOR CAPTURING GLYCATED PROTEIN IN A SAMPLE AND DEVICE AND METHOD FOR MEASURING THE GLYCATED PROTEIN USING THE SUPPORT - Provided is a support for effectively capturing glycated protein in a sample, and a device and method for measuring the glycated protein by using the support. | 08-07-2014 |
| 20140219870 | Optical Device For Performing An Assay - There is provided a device, such as a microfluidic device, for performing an assay including: a substrate comprising a channel, such as a microfluidic channel; at least one optical element having an input port arranged to be optically coupled to a light source; an output port optically coupled to at least a portion of the channel; and a light guide portion optically connecting the input port and output port; and a detection port optically coupled to said at least a portion of the channel. The device provides an improved geometry which addresses problems related to traditional orthogonal detection arrangements and in-line detection systems. | 08-07-2014 |
| 20140219871 | MULTI-CHANNEL FLOWCELL - A flow cell unit to be docked against a flat lid surface to form a closed flow cell arrangement, the flow cell unit comprising a top surface with protruding walls of elastic material defining three or more adjacent elongated flow channels, each flow channel comprises a first fluid port and a second fluid port, wherein the walls separating adjacent flow channels comprises a valve section of reduced height, thereby allowing selective opening and closing of a flow path transverse to the elongated flow channels by controlling the docking force between flow cell and the lid surface to an open docking state and a closed docking state respectively. | 08-07-2014 |
| 20140234171 | RESONANT MASS SENSOR - A separate excitation and high sensitive resonant type mass sensor is provided. The resonant type mass sensor | 08-21-2014 |
| 20140271362 | RECOGNITION TEST STRIPS - Test strips for the detection of at least one analyte in a sample are shown and described. In one embodiment, the test strip includes a test zone, a control zone and a surface reflectance profile to monitor the test strip continuously until the presence or absence of an analyte is detected. In other embodiments, a lateral flow assay includes a surface reflectance profile to monitor the test strip prior to the detection. The surface reflectance profile may include at least one flow reference area and/or at least one test result reference area. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample. | 09-18-2014 |
| 20140271363 | DIFFRACTION BASED BIOSENSOR CONTAINING TWO DIFFRACTIVE GRATINGS - The present disclosure provides a diffraction based biosensor containing at least two diffraction gratings. The first grating is referred to as an in-coupling diffraction grating and the coherent light source (laser) is directed to illuminate the in-coupling grating, and the biosensor is configured such that a selected order of the light beam diffracted from the in-coupling diffraction grating illuminates a second biosensor grating coated with analyte-specific receptors which are selected to preferentially bind with analytes being tested for that may or may not be located in a sample being tested. | 09-18-2014 |
| 20140271364 | ELECTRO-IMMUNO SENSING DEVICE - An electro-immuno sensor includes a signal generator, a sensing chip and a sensing circuit. The signal generator is arranged for generating an electronic signal having a predetermined frequency and a waveform. The sensing chip is disposed in an electrical field that generates the electronic signal, and arranged for capturing target biomolecules in a solution using antibodies. The sensing circuit has a first electrode and a second electrode in contact with the solution, and arranged for measuring an electrical characteristic of a first state and the electrical characteristic of a second state between the first and second electrodes, due to the capture of the target biomolecules, and determining the concentration of the target biomolecules according to the variation of the electrical characteristic. | 09-18-2014 |
| 20140271365 | DNA/NANOPARTICLE COMPLEX ENHANCED RADIO FREQUENCY TRANSPONDER: STRUCTURE OF MARK FOR DETECTING HYBRIDIZATION STATE AND AUTHENTICATING AND TRACKING ARTICLES, METHOD OF PREPARING THE SAME, AND METHOD OF AUTHENTICATING THE SAME - An apparatus consisting of a ‘DNA/Nanoparticle Complex Enhanced Radio Frequency Transponder’ with unique features, said apparatus including an antenna pattern precursor, wherein the antenna pattern precursor includes a plurality of sensitive regions; and electromagnetically functionalized DNA/nanoparticle complex(es) that individualize the ability to transition between the precursor antenna electrical and resonant frequency characteristics, and activated antenna electrical and resonant frequency characteristics through DNA hybridization of the specific sequences contained in the electromagnetically functionalized DNA/nanoparticle complex(es). | 09-18-2014 |
| 20140271366 | Method and Apparatus for Chemical Detection - Provided herein is a sensing apparatus comprising, at least one LSPR light source, at least one detector, and at least one sensor for LSPR detection of a target chemical. The sensor comprises a substantially transparent, porous membrane having nanoparticles immobilized on the surface of its pores, the nanoparticles being functionalized with one or more capture molecules. | 09-18-2014 |
| 20140271367 | FLUID SPECIMEN COLLECTION DEVICE - A drug test device for bodily fluids, such as urine, includes a cup and a removable lid which houses one or more test strips. The lid is releasably locked onto the cup so as to align dipping ends of the test strips exposed through an underside of the lid with a position stabilizer, thereby causing the dipping ends to be located downwardly and submerged in fluid when the device is placed on its side in a reactive position. The position stabilizer may comprise a sidewall indentation that reduces the internal volume of the cup and keeps the cup from rolling when placed on its side. | 09-18-2014 |
| 20140294674 | BIOCHIP - A biochip includes a flat carrier and an array of spots containing catcher molecules which are arranged on the carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the catcher molecules and the target molecules applied via an analyte solution. In order to increase the sensitivity or the binding-specific measuring effects of the bio-chip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing catcher molecules and which is permeable to target molecules. | 10-02-2014 |
| 20140308168 | STRUCTURES FOR CONTROLLING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES - Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems. | 10-16-2014 |
| 20140334980 | DETECTION SENSOR SYSTEMS AND METHODS - Analyte detection systems and devices are provided. In one embodiment, a sensor initially reviews an assay, for instance a test strip, to designate a particular testing sequence. The sensor may calibrate the unit and then identify the particular testing sequence by identifying a color indicator on the test strip. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample. | 11-13-2014 |
| 20140348705 | MAGNETIC BEAD ACTUATION USING FEEDBACK FOR FTIR BIOSENSOR - The invention provides a method for controlling actuation of label particles in a biosensor device, in particular a biosensor device using frustrated total internal reflection. By applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device, a feedback control of the actuation force is applied. Furthermore, a biosensor device is provided which is adapted for forming the method according to the invention. | 11-27-2014 |
| 20140363336 | SPR SENSOR CELL AND SPR SENSOR - Provided are an SPR sensor cell having very excellent detection sensitivity and an SPR sensor. The SPR sensor cell includes a detection unit; and a sample mounting portion adjacent to the detection unit, wherein the detection unit includes an under clad layer, a core layer formed so that at least apart thereof is adjacent to the under clad layer, a metal layer covering the core layer, and a coat layer covering the metal layer; the coat layer is formed of a material having a band gap (Eg) of more than 1.0 eV and less than 7.0 eV; and a refractive index of the coat layer is higher than a refractive index of the core layer. | 12-11-2014 |
| 20140363337 | CHIP FOR OPTICAL ANALYSIS - The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or a health affecting substance in a liquid to be measured. The chip for optical analysis of the present invention is characterized in that (1) an adsorption region (filter region) is provided between a sample introduction section and the observation section in a passage of the chip for analysis, (2) a bypass passage is provided in the passage (main passage) of the chip for analysis, and a time lag is generated between samples passed through the main passage and passed through a bypass passage, and (3) a measurement region and a reference region are provided in the observation section of the chip for analysis. In the present invention, the aspects (1) to (3) can be achieved individually or two or more thereof can be combined | 12-11-2014 |
| 20150017065 | SYSTEM FOR DETERMINING BIOFUEL CONCENTRATION - A measurement device or system configured to measure the content of biofuels within a fuel blend. By measuring a state of a responsive material within a fuel blend, a biofuel content of the fuel blend may be measured. For example, the solubility of a responsive material to biofuel content within a fuel blend, may affect a property of the responsive material, such as shape, dimensional size, or electrical impedance, which may be measured and used as a basis for determining biofuel content. | 01-15-2015 |
| 20150017066 | LINE IMMUNOASSAY TESTING DEVICE - A testing device has a base and multiple strips connected to the base. Multiple antigens are placed on each strip. The testing device or strips may be affixed to a sheet under a shield. Fluid can be applied to the testing device or the strips. The testing device can be used for biochemical testing, such as line immunoassay (LIA) testing. | 01-15-2015 |
| 20150044097 | FILTRATION DEVICE FOR ASSAYS - A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and the result can be displayed. | 02-12-2015 |
| 20150056097 | IMAGING DEVICES FOR MOLECULE DETECTION - An imager may include an array of pixels formed on a substrate. A chemisorption layer such as a planar chemisorption layer may be deposited over the array of pixels. The chemisorption layer may include active sites that bond with anchoring molecules. The anchoring molecules may be bonded to the planar chemisorption layer in only localized regions each covering a respective pixel of the array of pixels. The image sensor may include a photoresist layer that covers the chemisorption layer. Openings in the photoresist layer may define the boundaries of the localized regions. The anchoring molecules may be bonded only with the chemisorption layer without bonding to the photoresist layer. The anchoring molecules may serve to bond with analyte molecules. By forming the anchoring molecules within only localized regions centered over respective pixels, spatial resolution of the imager when imaging the analyte molecules may be improved. | 02-26-2015 |
| 20150056098 | SAMPLE ANALYSIS DEVICE AND SAMPLE ANALYSIS METHOD - A problem of a sample analysis device that uses magnetic particles is the difficulty in uniformly capturing magnetic particles, specifically the poor uniformity in the vicinity of channel side walls. This causes poor analysis accuracy and reproducibility. The present invention is intended to provide a means to uniformly capture magnetic particles in the vicinity of channel side walls. Specifically, the present invention provides an analysis device that includes a detection channel with an inlet and an outlet through which a sample liquid containing a specific substance and magnetic particles is flowed in and out of the channel, and magnetic field generating means capable of varying the magnitude of the magnetic field in a predetermined region of the detection channel. The width of the magnet in the detector is greater than the channel width. The detector can improve the analysis accuracy and reproducibility of the analysis device. | 02-26-2015 |
| 20150056099 | DIAGNOSTIC RADIO FREQUENCY IDENTIFICATION SENSORS AND APPLICATIONS THEREOF - An integrated passive wireless chip diagnostic sensor system is described that can be interrogated remotely with a wireless device such as a modified cell phone incorporating multi-protocol RFID reader capabilities (such as the emerging Gen-2 standard) or Bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as thin films, MEMS, electrochemical, thermal, resistive, nano or microfluidic sensor technologies. Applications of the present invention include on-the-spot medical and self-diagnostics on smart skin patches, Point-of-Care (POC) analyses, food diagnostics, pathogen detection, disease-specific wireless biomarker detection, remote structural stresses detection and sensor networks for industrial or Homeland Security using low cost wireless devices such as modified cell phones. | 02-26-2015 |
| 20150086424 | Micro-Tube Particles for Microfluidic Assays and Methods of Manufacture - A microfluidic assay device that defines a micro-fluidic flow channel ( | 03-26-2015 |
| 20150086425 | CELLS FOR BIOCHEMICAL ANALYSIS, KIT FOR BIOCHEMICAL ANALYSIS, AND BIOCHEMICAL ANALYZER - The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum. | 03-26-2015 |
| 20150093291 | COMPETITIVE BINDING DENDRIMER-BASED SYSTEM FOR ANALYTE DETECTION - A sensitive, precise detector system for physiological analytes uses a novel system. The system comprises an immobilized polyol on a surface. Reversibly coupled to the polyol or analyte is a dendrimer structure. In the system, a signal is triggered by the dendrimer structure when in a competitive environment with an analyte at the surface. In one embodiment, the system is an implantable sensor for use by diabetic patients. The sensing system can produce a consistent, measurable response while functioning under biologically relevant conditions. The sensing system requires the interaction of two components: 1) a competitive agent/signaling component, a dendrimer-boronic acid construct (DBA) and 2) a binding environment for a glucose-competitive DBA competition, which is an immobilized monosaccharide mimic (iDIOL). | 04-02-2015 |
| 20150098864 | MICROFLUIDIC CHIP WITH FLOW-GUIDING BODY AND APPLICATIONS THEREOF - A microfluidic chip ( | 04-09-2015 |
| 20150104352 | USE OF DISULFIDE BONDS TO FORM A REVERSIBLE AND REUSABLE COATING FOR NANOFLUIDIC DEVICES - A reusable coating for a nanopore structure is disclosed herein. A nanopore structure includes a substrate comprising a nanochannel and a monolayer of a chemical compound disposed onto at least a portion of a surface of the nanochannel. The chemical compound forms a reversible bond with at least one analyte binding compound introduced into the nanochannel. Methods for making and using the reusable coating are also disclosed. | 04-16-2015 |
| 20150104353 | DIRECTED SURFACE FUNCTIONALIZATION ON SELECTED SURFACE AREAS OF TOPOGRAPHICAL FEATURES WITH NANOMETER RESOLUTION - A method for making a single molecule receptor in a nanopore structure includes depositing a material by a physical vapor deposition (PVD) technique onto a selected interior surface of a nanochannel and functionalizing a surface of the material with a chemical compound having at least two functional groups. The material forms a patch having a diameter of about 3 to about 10,000 nanometers (nm). Also disclosed are embodiments of a nanopore structure including a single molecule receptor. | 04-16-2015 |
| 20150104354 | NANOFLUIDIC SENSOR COMPRISING SPATIALLY SEPARATED FUNCTIONAL SENSING COMPONENTS - A method for making multiple single molecule receptors in a nanopore structure includes depositing a first material and a second material by a physical vapor deposition (PVD) technique onto different selected interior surfaces of a nanochannel and functionalizing a surface of the first material, the second material, or both the first and second materials with a chemical compound having at least two functional groups. The first and second materials can be the same or different and form patches having diameters of about 1 to about 100 nanometers (nm). Also disclosed are embodiments of a nanopore structure including multiple single molecule receptors. | 04-16-2015 |
| 20150125346 | Devices, Systems, and Methods for Conducting Assays with Improved Sensitivity Using Sedimentation - Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area. | 05-07-2015 |
| 20150132186 | MICROANALYSIS METHODS AND SYSTEMS USING FIELD EFFECT TRANSISTOR - Provided is a microanalysis method and system using a Field Effect Transistor (FET). The microanalysis method includes a channel region having a receptor molecule fixed; forming a nano-particle conjugate in the channel region by supplying a sample for test and the nano-particle conjugate to the FET; growing a probe material on the channel region; and measuring a current flowing through the channel region, wherein the receptor molecule is a material that is selectively bonded to a target molecule in the sample for test. | 05-14-2015 |
| 20150139856 | OPTICAL DEVICE AND DETECTION DEVICE - The optical device has a substrate having a dielectric body on a surface, a metal fine structure formed of a plurality of metal nanostructures formed on the dielectric body, and an organic molecular film formed on the dielectric body between the plurality of metal nanostructures, and adapted to capture target molecule. The plurality of metal nanostructures each has a diameter in a planar view of 1 through 500 nm, and has a distance between the metal nanostructures adjacent to each other of no smaller than 0.1 nm and smaller than 10 nm. The plurality of metal nanostructures has the distance between the metal nanostructures adjacent to each other at a second height position H2 from the surface of the dielectric body larger than a first distance between the metal nanostructures adjacent to each other at a first height position H1 (H2>H1) from the surface of the dielectric body. | 05-21-2015 |
| 20150139857 | BIOCHIP WITH BIOSENSORS AND FLUIDIC DEVICES - A biochip includes a substrate, where the substrate includes at least one hole extending from a first surface of the substrate to a second surface of the substrate opposite the first surface, and where the substrate comprises a microfluidic channel pattern. The biochip further includes a surface modification layer over the substrate. Additionally, the biochip includes a sensing wafer bonded to the substrate, where the sensing wafer has one or more modified surface patterns having different surface properties from each other. | 05-21-2015 |
| 20150290647 | SEMI-DYNAMIC LEACH TEST DEVICE AND METHODS OF MAKING AND USING - Disclosed herein is an insert device for semi-dynamic leach testing, the insert device including a support and an absorptive polymer disposed on the support, the insert device characterized by a sheet-like form having a first and second major side. The device is useful in testing of both radial and unidirectional leaching of organic compounds into water from solid samples. | 10-15-2015 |
| 20150323466 | CAVITY OPTO-MECHANICAL SENSOR SYSTEM - A mass sensor system including multiple Fabry-Perot microcavities connected in parallel by multiple waveguides. Each of the mass sensors includes a microbridge having a fundamental resonance frequency, and a movable reflective mirror etched into the microbridge; a fixed reflective mirror etched in a substrate, the fixed reflective mirror being fixed to the substrate in a region spaced apart from the movable reflective mirror; and an optical waveguide etched in the substrate that connects the movable mirror and the fixed mirror forming the Fabry-Perot microcavity interferometer. The system includes a tunable continuous-wave laser operative to optically interrogate the Fabry-Perot microcavity of each of the plurality of mass sensors, and a receiver operative to receive sensor signals from each of the plurality of mass sensors, the sensor signals comprising reflective signals and transmitted signals. A continuous-wave laser may generate optical forces that modify the motion, dynamics, or mechanical Q-factor of the microbridge. | 11-12-2015 |
| 20150377762 | AIRBORNE-SUBSTANCE DETECTION DEVICE AND CARTRIDGE USED IN SAME - An airborne-substance detection device includes a cartridge and an optical detector. The cartridge includes: an inflow plate having formed therein a micropore that allows inflow of a microparticle-containing gas; a trapping plate disposed opposite the micropore and having the ability to capture the microparticles on a surface facing the micropore; and a main body in which the inflow plate and the trapping plate are installed, and in which a channel is formed that channels the gas to the micropore. The optical detector optically detects the microparticles captured on the trapping plate. The trapping plate is disposed on the outermost side of the cartridge, and is configured from a light transmissive member. The optical detector detects the captured microparticles on the trapping plate from the back side of the trapping plate. | 12-31-2015 |
| 20150377872 | MEDICAL DIAGNOSTIC TEST SYSTEMS, AND A MATRIX THEREFOR - The invention discloses a reduced thickness membrane matrix for carrying liquids consisting of a cellulosic material with a thickness of between 10 and 50 μm and a pore size between 0.1 μm and 20 μm for use with diagnostic tests such as lateral flow tests, thereby reducing the amount of test reagents required. | 12-31-2015 |
| 20160025636 | SUBSTRATES, DEVICES, AND METHODS FOR QUANTITATIVE LIQUID CRYSTAL ASSAYS - The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific binding of an analyte to a substrate by using a liquid crystal assay format. | 01-28-2016 |
| 20160033403 | METHODS FOR FABRICATING MORPHOLOGICALLY TRANSFORMED NANO-STRUCTURES (MTNS) AND TUNABLE NANOCOMPOSITE POLYMER MATERIALS, AND DEVICES USING SUCH MATERIALS - In order to implement a microfluidics sensor having higher efficiency, Applicants have developed a method of formation of nano-structures having various shapes and sizes onto materials such as polymers, glass and silicon, which are compatible with the microfabrication processes. The adhesion of the nano-structures and feasibility to tune their properties (optical, electrical and mechanical) are two prime concerns when they are adopted for microfluidics devices. | 02-04-2016 |
| 20160033498 | NANOSENSORS AND RELATED TECHNOLOGIES - The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like. | 02-04-2016 |
| 20160069875 | Labelled Silica Nanoparticles for Immunochromatographic Reagent, Immunochromatographic Test Strip Using the Same, and Immunochromomatographic Fluorescence-Detecting System or Radiation-Detecting System - Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance. | 03-10-2016 |
| 20160116444 | SENSORS, METHODS OF MAKING AND DEVICES - Disclosed sensors can include at least one resonator (in some embodiments, at least two resonators) and various other structures that may be formed in association with the resonators. The at least one resonator in embodiments can include a bottom electrode, a piezoelectric layer, and a top electrode, wherein the piezoelectric layer is positioned between the bottom electrode and the top electrode. | 04-28-2016 |
| 20160116465 | Fluorescence excitation device and portable fluorescence analysis system with the same - A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing. | 04-28-2016 |
| 20160153979 | HETEROGENOUS SURFACE FUNCTIONALIZATION | 06-02-2016 |
| 20160154015 | MICROFLUIDIC DEVICE TO DETECT CANNABIS IN BODY FLUIDS | 06-02-2016 |
| 20160155948 | CARBON NANOTUBE COMPOSITE, SEMICONDUCTOR DEVICE, AND SENSOR USING SAME | 06-02-2016 |
| 20160169874 | SENSOR | 06-16-2016 |
| 20160178523 | DETECTION PLATE | 06-23-2016 |
| 20160178640 | LATERAL FLOW MEMBRANE ARRANGEMENT AND LATERAL FLOW IMMUNOASSAY DEVICE COMPRISING THE SAME | 06-23-2016 |
| 20160195488 | AN ENCASED POLYMER NANOFIBER-BASED ELECTRONIC NOSE | 07-07-2016 |
| 20160202190 | DEVICE FOR DIGITAL READING OF QUICK TESTS | 07-14-2016 |
| 20160202250 | Chemiresistive Biosensor for the Quantitative Detection of Human Cardiac Biomarker and a Process Thereof | 07-14-2016 |
| 20160202275 | SPECIMEN CONTAINING UNIT, SPECIMEN MEASUREMENT CASSETTE, SPECIMEN MEASUREMENT UNIT, AND SPECIMEN MEASUREMENT DEVICE | 07-14-2016 |
| 20160377611 | CHEMICAL SENSOR USING MOLECULARLY-IMPRINTED SINGLE LAYER GRAPHENE - Sensing methods are sought to overcome the disadvantages—poor sensitivity and selectivity, poor long-term stability, and undeployable. Sensor of these teachings for detecting and recognizing target molecules includes a layer of molecularly imprinted polymer disposed on a single layer graphene sheet. In some instances, the sensor of these teachings also includes a sensing circuit configured to detect and report impedance changes in a layer of molecularly imprinted polymer disposed on a single layer grapheme sheet, the impedance changes caused by the binding of the target molecules to the molecularly imprinted polymer. | 12-29-2016 |
| 20180024060 | APPARATUS FOR OPTICAL DETECTION OF BIO-CONTAMINANTS BY COMPARING INTENSITIES OF FILTERED LIGHT AT TWO PREDETERMINED WAVELENGTHS | 01-25-2018 |
| 20180024092 | FIELD-EFFECT APPARATUS, ASSOCIATED APPARATUS AND METHODS | 01-25-2018 |
| 20180024127 | OPTOCHEMICAL DETECTOR AND A METHOD FOR FABRICATING AN OPTOCHEMICAL DETECTOR | 01-25-2018 |
