| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 204603000 | With detailed detection system (e.g., including a light source and a camera, etc.) | 41 |
| 20090134030 | Capillary Electrophoretic Instrument and Capillary Array Assembly - The troublesomeness during the setting of a plurality of capillaries is eliminated by composing pairs of electrodes, which are electrically connected to the common electrode, and capillaries. By bringing electrodes installed in the vicinity of each capillary disposed at the pitch of wells on the side of sample plate (within the area of the wells) into electrical contact with a common electrode, the capillaries and electrodes are made integral in construction. When a voltage is applied to the electrophoretic instrument via a common electrode portion, the voltage is applied to the electrodes for each capillary. This enables an inexpensive microtiter plate, etc. to be used and a multiple of capillaries to be simultaneously inserted, attached and detached. | 05-28-2009 |
| 20090183990 | CAPILLARY ARRAY UNIT AND CAPILLARY ELECTROPHORESIS APPARATUS - In a capillary electrophoresis apparatus, a capillary array unit has a capillary array including capillaries having a capillary head and a detection unit, a frame for supporting the capillary array, and a load header for holding cathode ends of the capillaries. The frame has separators for separating and holding the capillaries. The capillary head, the detection unit, and the separators are disposed along one linear line. With this arrangement, there is provided the capillary array unit and the capillary electrophoresis apparatus which are arranged such that a job for mounting the capillary array can be executed easily. | 07-23-2009 |
| 20090200169 | CAPILLARY ELECTROPHORESIS DEVICE - An object of the present invention is to prevent a variation in heat dissipating effect of a capillary between a holder part and an oven, to improve reproducibility of migration time, and to reduce a variation of migration time among capillaries in a single electrophoresis run. A cylindrical wall is formed in an upper part of a septa that covers a container holding a solution, and the cylindrical wall surrounds a capillary hole through which a capillary penetrates. Accordingly, the capillary is prevented from being directly affected by wind generated between the septa and the oven. | 08-13-2009 |
| 20090211911 | CAPILLARY ELECTROPHORESIS APPARATUS - The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage. | 08-27-2009 |
| 20090255814 | ELECTROPHORESIS DEVICE - The invention aims to improve the spatial resolution in a multi-focus type electrophoresis apparatus that irradiates a capillary array from both ends thereof with laser beams. The invention relates to an electrophoresis apparatus in which capillaries at both ends of a capillary array are irradiated respectively with laser beams, and each of the two laser beams traverses multiple capillaries. In the electrophoresis apparatus, the laser beams are coaxially introduced into the capillary array from the both ends thereof to travel in a direction vertical to axis of each capillary and horizontal to the aligrnent plane of the capillary array; and a λ/4 plate and a polarizer are arranged on the laser beam optical axes. According to the invention, the total width of the incident laser beams is made narrow, generation of pseudo signals is prevented, and an analysis performance is improved. | 10-15-2009 |
| 20100051464 | ANALYSIS CHIP AND ANALYSIS APPARATUS - An analysis chip that enables an apparatus to be small, analysis to be simple, analysis time to be short and analysis of both glycosylated hemoglobin and glucose to be highly accurate is provided. The electrophoresis chip includes an upper substrate | 03-04-2010 |
| 20100059379 | SYSTEM FOR DETECTING ELECTROPHORESIS - The invention describes a detection system ( | 03-11-2010 |
| 20100147692 | Automated Parallel Capillary Electrophoresis System with Hydrodynamic Sample Injection - An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples. | 06-17-2010 |
| 20100288642 | CAPILLARY ARRAY - A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus. | 11-18-2010 |
| 20110068007 | MULTI-WAVELENGTH FLUORESCENCE DETECTION SYSTEM FOR MULTIPLEXED CAPILLARY ELECTROPHORESIS - Using multiple dichroics mirrors to split and redirect different wavelength regions of light in a multi-wavelength fluorescence detection system. | 03-24-2011 |
| 20110094886 | Automated, High Band Resolution Electrophoretic System for Digital Visualization and Method of Use - A concept of high resolution electrophoretic technique, apparatus and its application thereof. The system is a functioning entity in a radial-flat setting. Unlike the conventional rectangular gel-electrophoresis setup, wherein two electrically opposite poles are placed on opposite sites of a rectangular gel, the novel system places one of the electrical poles in the middle of the gel and the outer rims of the radial gel is exposed to the other pole. The point, central pole (positive/negative) and the radial (negative/positive) pole around the outer rim of the gel will create and maintain a gradient electric field, wherein the intensity of the electric field increases towards the central pole with an inverse proportionally to the decrease in the surface area towards the center in a radial-gradient setting. When combined with the gradient gel setup, which increases towards the center of the gel in agarose, PAGE, and in any-other media as well as gradient and non-gradient and any-other means the system has a higher resolution potential. At higher voltages moderate heating of the central electrode forms a natural heat gradient, suitable for SSCP and DGGE analyses. Additionally, radial design bestows the system better data visualization and recording potential comparable to DVD writing and reading technology. | 04-28-2011 |
| 20110220508 | Automated Parallel Capillary Electrophoresis System with Hydrodynamic Sample Injection - An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples. | 09-15-2011 |
| 20110247938 | FIELD-PROGRAMMABLE LAB-ON-A-CHIP BASED ON MICROELECTRODE ARRAY ARCHITECTURE - The system relates to filed-programmable lab-on-chip (FPLOC) microfluidic operations, fabrications, and programming based on Microelectrode Array Architecture are disclosed herein. The FPLOC device by employing the microelectrode array architecture may include the following: (a) a bottom plate comprising an array of multiple microelectrodes disposed on a top surface of a substrate covered by a dielectric layer; wherein each of the microelectrode is coupled to at least one grounding elements of a grounding mechanism, wherein a hydrophobic layer is disposed on the top of the dielectric layer and the grounding elements to make hydrophobic surfaces with the droplets; (b) a field programmability mechanism for programming a group of configured-electrodes to generate microfluidic components and layouts with selected shapes and sizes; and, (c) a FPLOC functional block, comprising: (i) I/O ports; (ii) a sample preparation unit; (iii) a droplet manipulation unit; (iv) a detection unit; and (iv) a system control unit. | 10-13-2011 |
| 20110253540 | BIO-ANALYSIS USING BALL-ENDED INCIDENT AND OUTPUT OPTICAL FIBERS - A detection optics configuration for bio-analysis, in which the direction of incident radiation, the axis of the separation channel, and the direction of collection of the output radiation are coplanar at the detection zone. The detection configuration incorporates ball-end optical fibers to direct incident radiation at and collection of output radiation from the detection zone. The detection optics configuration may be implemented in an improved bio-separation instrument, in particular a capillary electrophoresis instrument. | 10-20-2011 |
| 20110284378 | APPARATUS AND MICROCHIP FOR SORTING MICRO PARTICLES - In one example embodiment, a micro-particle sorting apparatus includes: (a) a microchip in which a flow path through which liquid containing a micro particle flows and an orifice through which the liquid flowing through the flow path is discharged into a space outside the chip; (b) an oscillating element for transforming the liquid into a liquid drop and discharging the liquid drop at the orifice; (c) a charge means for adding an electric charge to the discharged liquid drop; (d) an optical detection means that detects an optical property of the micro particle flowing through the flow path, upstream of a liquid-delivering direction with respect to the orifice; (e) paired electrodes opposed to each other while sandwiching the moving liquid drop along a movement direction of the liquid drop discharged into the space outside the chip; and two containers that collect the liquid drop passing between the paired electrodes. | 11-24-2011 |
| 20110284379 | DIRECT DETERMINATION OF CARBOHYDRATES, AMINO ACIDS AND ANTIBIOTICS BY MICROCHIP ELECTROPHORESIS WITH PULSED AMPEROMETRIC DETECTION - The present invention provides a microchip for performing electrophoresis with pulsed amperometric detection (PAD) for the separation and detection of underivatized carbohydrates, amino acids, sulfur-containing antibiotics, etc. PAD allows for the direct detection of amines, thiols, alcohols and carbohydrates and therefore is a useful technique for the development of electrochemical detection for microchip electrophoresis. | 11-24-2011 |
| 20120024707 | CAPILLARY ELECTROPHORESIS APPARATUS - The solution reservoir apparatus of the capillary electrophoresis apparatus securely affixes an evaporation-preventing membrane to a container when a capillary is inserted or withdrawn, without extending the cathode end of the capillary. The solution reservoir apparatus comprises a container for reserving a sample or solution, a cover having a bore through which the capillary is passed and covering the container, an evaporation-preventing membrane having a capillary hole through which the capillary is passed, and a container holder for holding the container. The evaporation-preventing membrane has a projection provided at the periphery of the capillary hole, the projection of the evaporation-preventing membrane is engaged with the bore on the cover when the evaporation-preventing membrane is positioned on the cover, and the evaporation-preventing membrane is supported by the cover. | 02-02-2012 |
| 20120031762 | ELECTROPHORESIS DEVICE AND PUMP - Bubbles can be removed regardless of an individual difference of a pump to fill an electrophoresis medium into a capillary. Of flow passages formed between an inner side surface of a container for accommodating the electrophoresis medium and a side surface of a plunger, one of the flow passages causing an electrophoresis medium to be easily stagnant is formed to have the cross-sectional area larger than the cross-sectional area of the other flow passage on the opposite side. In other words, the flow passage portion causing the electrophoresis medium to be easily stagnant is formed in such a manner as to increase a flow amount of the electrophoresis medium. This can eliminate a region having an extremely small amount of electrophoresis medium flow in the pump. | 02-09-2012 |
| 20120080316 | System and Method For The Separation of Analytes - A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”). | 04-05-2012 |
| 20120145549 | NANOSENSOR AND METHOD OF MANUFACTURING THE SAME - A nanosensor includes a substrate including a hole which extends through the substrate, a thin layer on the substrate and including a nanopore which is connected to the hole, and a first graphene layer and a second graphene layer which are on the thin layer and spaced apart from each other centering the nanopore therebetween. A method of manufacturing the nanosensor includes forming a nanopore in a thin layer on a substrate, and forming a first graphene layer and a second graphene layer on the thin layer. The first graphene layer and the second graphene layer are spaced apart from each other centering the nanopore therebetween. | 06-14-2012 |
| 20120160691 | CONTACTLESS CONDUCTIVITY DETECTOR - A portable electrophoretic contactless conductivity detection (C | 06-28-2012 |
| 20120168312 | DISPOSIBLE BIO-ANALYSIS CARTRIDGE AND INSTRUMENT FOR CONDUCTING BIO-ANALYSIS USING SAME - A cartridge-based bio-separation system configured to utilize a pen shaped bio-separation cartridge that is easy to assemble and use with no moving parts and that has an integrated reagent (separation buffer) reservoir. The cartridge includes a body, defining an opening as a detection window for receiving external detection optics, at least one capillary column supported in the body, having a first end extending beyond a first end of the body, wherein the detection window exposes a section along the capillary column, to which the external optics are aligned through the detection window, and a reservoir attached to a second end of the body in fluid flow communication with a second end of the capillary column. The reservoir is structured to be coupled to an air pressure pump that pressurizes the gel reservoir to purge and fill the capillaries with buffer as the separation support medium. | 07-05-2012 |
| 20120193236 | ELECTRON BEAM SCULPTING OF TUNNELING JUNCTION FOR NANOPORE DNA SEQUENCING - A nanodevice is provided that includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an electrode layer having a tunneling junction formed therein. A nanopore is formed through the membrane, and the nanopore is formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base. | 08-02-2012 |
| 20120285832 | INTEGRATED MODULAR UNIT INCLUDING AN ANALYTE CONCENTRATOR-MICROREACTOR DEVICE CONNECTED TO A CARTRIDGE-CASSETTE - The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette. | 11-15-2012 |
| 20130032483 | Plastic Microfluidic Separation and Detection Platforms - Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described. | 02-07-2013 |
| 20130175175 | MEMBRANE CONFINED ELECTROPHORESIS - A membrane confined electrophoresis cuvette assembly is used to measure the effective charge and electrophoretic mobility of macromolecules in solution. The cuvette assembly features a sample including macro-ions or macromolecules of undetermined type and quantity that is held in suspension in a quartz cuvette sealed at either end by membranes. An electrical current is passed through the cuvette which establishes an electric field along the length of the cuvette assembly. The electric field forces charged macroions to move through the cuvette. The cuvette is bathed in collimated UV light while an absorbance profile measures the ion concentration distribution along the cuvette. The membrane confined electrophoresis provides two complimentary modes of sample analysis: steady state electrophoresis and real-time electrophoretic mobility. The cuvette assembly can be used with a software program that features experiment design control, and complete data analysis of the experiment(s). | 07-11-2013 |
| 20130248369 | Microfluidic Interface For a Microchip - A capillary electrophoresis system which provides a microfluidic chip for capillary electrophoresis and a microfluidic interface module which fluidicly couples the microfluidic chip to external fluid sources and or external repositories. | 09-26-2013 |
| 20130292251 | ELECTROPHORESIS APPARATUS, CAPILLARY ARRAY, AND CAPILLARY UNIT - In an apparatus for analyzing small number of samples, wasteful consumption of a polymer as a separation Medium is suppressed. | 11-07-2013 |
| 20130334049 | MULTI-COLOR DETECTION SYSTEM FOR MULTIPLEXED CAPILLARY ELECTROPHORESIS - A multi-wavelength detector for a multiplex capillary electrophoresis system comprising a linear filter placed in between the capillary detection windows and a 2-dimensional detector. The linear filter is oriented such that the change in wavelength of the filter is in the direction of flow of the fluid within the capillary detection windows. And a method for time shift correction and to merge all peaks into a single overlapped peak. | 12-19-2013 |
| 20140021053 | Method and apparatus for precise seletion and extraction of a focused component in isoelectric focusing performed in micro-channels - An apparatus and method are disclosed for the precise selection and extraction of a selected analyte in a focused zone produced by isoelectric focusing performed in micro-channels. A cross-channel microfluidic device comprises a sample mixture introduction and separation channel and an extraction channel, which are in fluid communication with each other at a point of intersection. Means are provided for selectively moving the pattern of separated zones following cIEF to the intersection point, and means are provided for applying an extraction pressure to direct a single zone containing a selected analyte into and then out of the extraction channel for collection. | 01-23-2014 |
| 20140166487 | High-Resolution Molecular Sensor - A solid state molecular sensor having an aperture extending through a thickness of a sensing material is configured with a continuous electrically-conducting path extending in the sensing material around the aperture. A supply reservoir is connected to provide a molecular species, having a molecular length, from the supply reservoir to an input port of the aperture. A collection reservoir is connected to collect the molecular species from an output port of the aperture after translocation of the molecular species from the supply reservoir through the sensing aperture. The sensing aperture has a length between the input and output ports, in the sensing material, that is substantially no greater than the molecular length of the molecular species from the supply reservoir. An electrical connection to the sensing material measures a change in an electrical characteristic of the sensing material during the molecular species translocation through the aperture. | 06-19-2014 |
| 20140318971 | NANOPORE SENSOR FOR DETECTING MOLECULAR INTERACTIONS - A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule. | 10-30-2014 |
| 20140339090 | Electric Controlled Micro-Fluidic Device - An example micro-fluidic device includes a micro-fluidic channel having an inner surface and a plurality of pillars positioned along the inner surface. The device further includes a plurality of power supplies connected to the pillars. Another example micro-fluidic device includes a micro-fluidic channel having an inner surface and a plurality of pillars positioned along the inner surface. The device further includes a power supply. The pillars are grouped into at least two groups of pillars, each group of pillars including at least two pillars, and all pillars of at least one group of pillars are connected to the power supply. In another example, a sensing system for detecting bioparticles includes a micro-fluidic device, wherein a surface of each pillar comprises functionalized plasmonic nanoparticles or functionalized SERS nanoparticles, a radiation source for radiating the micro-fluidic device, and a detector for detecting SERS signals or surface plasmon resonance. | 11-20-2014 |
| 20140346047 | APPARATUS AND MICROCHIP FOR SORTING MICRO PARTICLES - A micro-particle sorting apparatus is provided including a microchip in which a flow path through which liquid containing a micro particle flows and an orifice; an oscillating element configured to transform the liquid into a liquid drop; a charge means for adding an electric charge to the discharged liquid drop; an optical detection means; paired electrodes sandwiching the moving liquid drop; and at least a container that collects the liquid drop, and wherein the flow path is configured to gradually decrease, from upstream of the orifice, in cross-section area perpendicular to the liquid-delivering direction between the location at which the optical property is detected and the location of the orifice. | 11-27-2014 |
| 20150008130 | System and Method For the Separation of Analytes - A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”). | 01-08-2015 |
| 20150027893 | MICRO-CHANNEL CHIP - A convenient technique allows detecting fluorescence emitted in the channel with a uniformly high detection sensitivity and a good reproducibility. | 01-29-2015 |
| 20150083597 | Perforated MOS Structure for Single Biomolecule Detection - A perforated metal oxide semiconductor (MOS) structure for single biomolecule, virus, or single cell detection is disclosed. The structure includes a nanochannel formed through a sensing region configured to allow a solution containing particles to pass through the perforated MOS sensor. First and second terminals are configured to measure electrical parameters representative of change of electrical characteristics of the solution as the particle passes through the perforated MOS structure. | 03-26-2015 |
| 20150107999 | Apparatus for Pathogen Detection - An apparatus for separating an analyte from a test sample, such as bacteria from blood components, based on their dielectric properties, localizing or condensing the analyte, flushing substantially all remaining waste products from the test sample, and detecting low concentrations of the analyte. The module array includes a plurality of microfluidic channels with connecting microfluidic waste channels for directing undesired material away from the analyte. An electric field is applied causing a positive dielectrophoretic force to the analyte to capture the analyte. The electric field is applied to at least one electrode having a plurality of concentric rings or concentric arcs extending radially outwards from a center point, electrically connected to a voltage source such that when voltage is applied to the at least one electrode, the concentric rings or concentric arcs alternate in voltage potential. | 04-23-2015 |
| 20150355148 | Interfacing Capillary Electrophoresis to a Mass Spectrometer via an Impactor Spray Ionization Source - A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebuliser and a target. Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target so as to ionise the analyte to form a plurality of analyte ions. | 12-10-2015 |
| 20160025677 | PARTICLE CONCENTRATION SYSTEM - Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface. | 01-28-2016 |
| 20160153936 | Capillary Electrophoresis Device | 06-02-2016 |
