QIAGEN GAITHERSBURG INC. Patent applications |
Patent application number | Title | Published |
20140199686 | COMPOSITIONS AND METHODS FOR RECOVERY OF NUCLEIC ACIDS OR PROTEINS FROM TISSUE SAMPLES FIXED IN CYTOLOGY MEDIA - The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples. | 07-17-2014 |
20140113278 | SAMPLE PROCESSING APPARATUS AND METHODS - An automated process for converting samples includes: receiving tube strips having a number of sample tubes and samples therein, transferring multiple tube strips to a tube strip holder, dispensing sample conversion buffer into each tube, shaking the tube strip holder a first time, centrifuging the tube strip holder, removing a liquid supernatant from each tube, simultaneously inspecting the contents of each tube, dispensing a specimen transport medium and a denaturation reagent into each tube, shaking the tube strip holder a second time, heating the tube strip holder for a first length of time, shaking the tube strip holder a third time, heating the tube strip holder for a second length of time, shaking the tube strip holder a fourth time, and transferring at least a portion of each sample to a respective well on an output plate. | 04-24-2014 |
20140113277 | ULTRASONIC BIOLOGICAL SAMPLE ANALYSIS APPARATUS AND METHODS - An ultrasonic sample evaluation process in which a vial containing a liquid medium is placed on a receptacle and a ultrasonic source signal is propagated upwards in the vertical direction through the liquid medium. A number of reflected ultrasonic signals is received at the bottom of the sample vial and evaluated to identify a pattern characteristic of a reflection off the meniscus, and the presence of a pattern characteristic of a collection implement located in the liquid medium. An estimate of the amount of liquid medium contained in the sample vial is generated based on a time characteristic of the pattern characteristic of a reflection off the meniscus, and a signal indicating the presence of a collection implement in the liquid medium is generated upon identifying such a pattern. | 04-24-2014 |
20140112845 | CONDENSATION-REDUCING INCUBATION COVER - A cover for covering an array of sample tubes during an incubation process. The cover has an upper panel and protrusions extending downward from the upper panel. Each protrusion has an upper seal and a lower seal. The upper seal includes a first conical section that tapers from a first diameter that is larger than the inside diameter of a corresponding sample tube to a second diameter that is smaller than the inside diameter of the corresponding sample tube. The lower seal includes a cylindrical section extending downward from the bottom of the first conical section. The cylindrical section has a diameter selected to create a capillary seal, in the presence of a liquid, between the cylindrical section and an adjacent portion of an inner wall of the corresponding sample tube. | 04-24-2014 |
20140112843 | AUTOMATED PELLETIZED SAMPLE DECANTING APPARATUS AND METHODS - An automated sample tube decanting system having one or more decanting grippers, a decant waste receptacle, a transporter, and means for rotating the decanting gripper. Each decanting gripper has a respective holder configured to selectively mate with a respective interface on a tube strip. The one or more decanting grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the one or more decanting grippers in a lateral direction from a starting location to a location above the decant waste receptacle. | 04-24-2014 |
20140112842 | AUTOMATED PELLETIZED SAMPLE BLOTTING APPARATUS AND METHODS - An automated sample tube blotting system having one or more rotating grippers, a supply of absorbent material, a transporter, and an absorbent material removal mechanism. Each rotating gripper has a respective holder configured to selectively mate with a respective interface on a tube strip, and the one or more rotating grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the rotating gripper in a lateral direction from a starting location to a location above the absorbent material, and in a vertical direction towards and away from the absorbent material. | 04-24-2014 |
20140112829 | TUBE STRIP HANDLING AND HEATING APPARATUS - A tube strip handling and heating frame having a rectangular outer frame having two spaced longitudinal walls extending in a longitudinal direction, and two spaced lateral walls extending in a lateral direction and extending between respective ends of the longitudinal walls. The outer frame forms an enclosure having an open upper side and an open lower side. The frame also has a number of tube strip wells located inside the outer frame, each tube strip well has a slot elongated in the lateral direction, and each slot is configured to receive a respective tube strip through the open upper side and support the respective tube strip in a vertical direction. The tube strip wells are arranged in a series along the longitudinal direction. | 04-24-2014 |
20140112558 | AUTOMATED PELLETIZED SAMPLE VISION INSPECTION APPARATUS AND METHODS - A method for visually inspecting pelletized samples. The method generates an inspection image of the bottom of a sample tube holder. The sample tube holder has a number of sample tube locations, and each sample tube location is configured to receive a sample tube in it. The inspection image is evaluated to determine whether a tube image exists for each sample tube location, and each sample tube image is evaluated to determine whether a pellet is located in each sample tube. | 04-24-2014 |
20130315800 | MAGNETIC MICROPLATE ASSEMBLY - Magnetic microplate assemblies are disclosed for assaying of biological activated magnetic particles from a supernatant. The assemblies include a magnetic microplate holder and a microplate including a plurality of wells for retaining the magnetic particles. The microplate holder includes a plurality of magnets for attracting the magnetic particles to the wells and a plurality of detents for securing the microplate in the holder. The detents allow the microplate to be tightly retained in the holder when the assembly is turned over to discard supernatant and wash buffer applied to rinse supernatant from the magnetic particles. | 11-28-2013 |
20130209990 | DETECTION OF NUCLEIC ACIDS BY TYPE-SPECIFIC HYBRID CAPTURE METHODS - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid sequences. The method produces DNA/RNA hybrids which can be detected by a variety of methods. | 08-15-2013 |
20130203632 | DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods. | 08-08-2013 |
20130115590 | MATERIALS AND METHOD FOR IMMOBILIZING, ISOLATING, AND CONCENTRATING CELLS USING CARBOXYLATED SURFACES - The present disclosure relates to immobilization of a cell using a carboxylated surface by contacting the carboxylated surface with a sample comprising the cell for a sufficient time to permit the cell to bind to the carboxylated surface. The immobilized cell may then be separated from the remainder of the sample and further manipulated to isolate, concentrate, and/or analyze the cell or a component thereof. | 05-09-2013 |
20130011830 | FAST RESULTS HYBRID CAPTURE ASSAY AND SYSTEM - The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample. | 01-10-2013 |
20120322049 | MATERIALS AND METHODS FOR DETECTION OF HPV NUCLEIC ACIDS - Provided are nucleic acids capable of hybridizing to HPV 16 and/or HPV 18 nucleic acids, in particular, mRNA encoding E2 and E6-7 gene products. Such nucleic acids are useful in methods of isolating RNA from a biological sample, methods and means for determining the presence of particular RNA splice-form variants in a biological sample, methods and means for determining the relative ratio of RNA ratios in a biological sample, methods and means for predicting the progression of precancerous cervical lesions, and methods and means for detecting disruption of genes or gene expression. | 12-20-2012 |
20120196274 | MATERIALS AND METHODS FOR GENOTYPING AND QUANTIFYING A HIGH-RISK HUMAN PAPILLOMAVIRUS - Nucleic acids, assays, and methods for the detection and quantification of high risk HPV types are disclosed. | 08-02-2012 |
20120178078 | Methods and Compositions for Nucleic Acid Detection - The present application relates to Multicomponent Nucleic Acid Enzymes (MNAzymes), which may be used for detecting, identifying and/or quantifying targets. More particularly, this application provides methods of designing and making more reliable MNAzymes, as well as compositions comprising MNAzyme components and methods of using MNAzymes. | 07-12-2012 |
20120045756 | METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC PURIFICATION AND MULTIPLEX ANALYSIS OF NUCLEIC ACIDS - Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step comprising contacting the target nucleic acid with a plurality of detectably labeled nucleic acid detection probes, wherein each (a) bears a different detectable label from the other detection probes, and/or (b) has a different melting temperature from probes bearing the same detectable label. Also disclosed are compositions and kits for use in such a method. | 02-23-2012 |
20120021460 | MATERIALS AND METHODS FOR ISOTHERMAL NUCLEIC ACID AMPLIFICATION - A method for isothermal amplification of a target nucleic acid sequence is disclosed. The target nucleic acid is amplified by an enzyme with helicase activity and an enzyme with reverse transcriptase activity and DNA-dependant DNA polymerase activity. Also disclosed is a kit for isothermal amplification of a target nucleic acid sequence, including HPV nucleic acids. The kit comprises a first enzyme with helicase activity and a second enzyme having both reverse transcriptase activity and DNA-dependant DNA polymerase activity. | 01-26-2012 |
20120012539 | WATER TREATMENT APPARATUS AND METHOD FOR USING SAME - A water treatment apparatus with a first filtration system and a second filtration system is disclosed. The first filtration system provides purified water to an automated assay device. The second filtration system receives wastewater from an outlet and removes contaminants from the wastewater which allows for direct disposal of the wastewater via environmentally responsible means. An automated assay device comprising the water treatment apparatus and a method of treating water used by the automated assay device is also disclosed. | 01-19-2012 |
20120004128 | FAST RESULTS HYBRID CAPTURE ASSAY AND ASSOCIATED STRATEGICALLY TRUNCATED PROBES - Strategically truncated probes specific for high-risk HPV nucleic acids, and methods for making and using the same, are disclosed herein. The disclosed probes, and methods of use thereof, permit fast and reliable detection of human papillomavirus in clinical samples without significant cross-reaction. | 01-05-2012 |
20110294111 | METHOD OF DETERMINING AND CONFIRMING THE PRESENCE OF AN HPV IN A SAMPLE - Methods are provided for genotyping a target nucleic acid in a sample. In various aspects, the methods comprise generating nucleic acid hybrids between probes specific for the genotypes of interest and the target nucleic acid and detecting hybridization in the sample. In other aspects, the methods comprise using multi-probe mixtures to reduce the volume of sample necessary to determine the genotype of the target nucleic acid. | 12-01-2011 |
20110245089 | LABORATORY CENTRAL CONTROL UNIT METHOD AND SYSTEM - The present disclosure provides a method for coordinating data between a plurality of sample processing systems comprising: providing, using a central control unit, data to a pre-analytical sample processing system identifying a sample undergoing pre-analytical processing, receiving data, at the central control unit, indicating the transfer of the sample to an analytical system, providing, from the central control unit (CCU), data associated with the sample to the analytical system, and receiving a result associated with the sample from the analytical system | 10-06-2011 |
20110217705 | METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC PURIFICATION AND MULTIPLEX ANALYSIS OF NUCLEIC ACIDS - Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step using two separate sequence-specific polynucleotide probes. Also provided are nucleic acids comprising SEQ ID NO: 1 to SEQ ID NO: 727 and nucleic acid probes and probe sets comprising the same. | 09-08-2011 |
20110196146 | METHODS, COMPOSITIONS, AND KITS FOR RECOVERY OF NUCLEIC ACIDS OR PROTEINS FROM FIXED TISSUE SAMPLES - Methods and materials for improving nucleic acid or protein recovery from samples preserved in liquid cytological preservative solutions by utilizing scavenging agents, such as hydrazine- and hydrazide-containing compounds, are provided. Lysis solutions comprising hydrazine- and hydrazide-containing compounds and kits comprising the same are also provided. | 08-11-2011 |
20110097708 | ASSESSMENT OF HUMAN PAPILLOMA VIRUS-RELATED DISEASE - This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits for carrying out the methods of this invention. | 04-28-2011 |
20110071031 | COMPOSITIONS, METHODS, AND KITS FOR ISOLATING AND ANALYZING NUCLEIC ACIDS USING AN ANION EXCHANGE MATERIAL - The present disclosure relates to methods for isolating, amplifying, and/or analyzing nucleic acids in the presence of an anion exchange material by performing the isolation, amplification and/or analysis step in the presence of at least one anionic compound. | 03-24-2011 |
20110065906 | COMPOSITIONS AND METHODS FOR RECOVERY OF NUCLEIC ACIDS OR PROTEINS FROM TISSUE SAMPLES FIXED IN CYTOLOGY MEDIA - The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples. | 03-17-2011 |
20110059542 | DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods. | 03-10-2011 |
20110053143 | METHODS AND KITS FOR DETERMINING VIRAL LOAD IN CLINICAL SAMPLES - Methods and kits for determining load of an infectious agent in a sample are described, comprising performing at least one hybridization assay and calculating the load of the infectious agent in the sample from a detected nucleic acid. In particular, the methods and kits disclosed determine the load of human papillomavirus (HPV) in a sample. | 03-03-2011 |
20110003288 | DETECTION OF NUCLEIC ACIDS BY TYPE-SPECIFIC HYBRID CAPTURE METHOD - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but also highly specific and capable of discriminating highly homologous nucleic acid sequences. The method produces DNA/RNA hybrids which can be detected by a variety of methods. | 01-06-2011 |
20100311039 | NON-TARGET AMPLIFICATION METHOD FOR DETECTION OF RNA SPLICE-FORMS IN A SAMPLE - Provided are methods of isolating RNA from a biological sample, methods and means for determining the presence of particular RNA splice-form variants in a biological sample, methods and means for determining the relative ratio of RNA ratios in a biological sample, and methods and means for predicting the progression of precancerous cervical lesions. | 12-09-2010 |
20100216147 | SEQUENCE-SPECIFIC LARGE VOLUME SAMPLE PREPARATION METHOD AND ASSAY - Methods of selectively and rapidly identifying target nucleic acid molecules in large volumes of collection media where the target is present in a low concentration are disclosed. The methods can be used to identify, isolate, purify, or enrich a nucleic acid molecule containing a specific target sequence from a sample of nucleic acid molecules that do not contain the specific target sequence. Once isolated, the nucleic acid molecule containing a specific target sequence may be amplified or used in a variety of detection assays. | 08-26-2010 |
20100159463 | FAST RESULTS HYBRID CAPTURE ASSAY AND SYSTEM - The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample. | 06-24-2010 |
20100105060 | FAST RESULTS HYBRID CAPTURE ASSAY ON AN AUTOMATED PLATFORM - The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample. | 04-29-2010 |
20100036104 | DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods. | 02-11-2010 |
20090298187 | COMPOSITIONS, METHODS, AND KITS USING SYNTHETIC PROBES FOR DETERMINING THE PRESENCE OF A TARGET NUCLEIC ACID - Compositions, methods, and kits are provided for determining the presence of a target nucleic acid in a sample using synthetic probes. | 12-03-2009 |