Merial Limited Patent applications |
Patent application number | Title | Published |
20150283228 | Recombinant Feline Leukemia Virus Vaccine Containing Optimized Feline Leukemia Virus Envelope Gene - The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions. | 10-08-2015 |
20150196487 | Vaccine Formulations Comprising Saponin-containing Adjuvants - The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof. | 07-16-2015 |
20150190502 | RECOMBINANT EQUINE HERPESVIRUS-1 VACCINE CONTAINING MUTATED GLYCOPROTEIN C AND USES THEREOF - The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions. | 07-09-2015 |
20150157704 | Newcastle Disease Virus Vectored Herpesvirus Vaccines - The present invention encompasses recombinant Newcastle Disease Virus-Herpesvirus vaccines or compositions. The invention encompasses recombinant NDV vectors encoding and expressing herpesvirus pathogen, antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals against disease. | 06-11-2015 |
20150136030 | Selective Embryonic Structure Targeting and Substance Delivery Device - The present disclosure relates to a device for delivering substances to specific embryonic structures, including heart and blood vessels, within a developing avian egg. The disclosure also relates to methods of using the device to produce enhanced avian embryos. Methods include administering to chicken embryos various substances, including vaccines, nutrients, and stem cells. Chickens resulting from enhanced avian embryos have advantages, including greater growth potential and resistance to pathogen infection/infestation. | 05-21-2015 |
20150128873 | Multi-chamber, Multi-formulation Fluid Delivery System - The application discloses a multi-chamber, multi-formulation fluid delivery system, comprising a multi-chamber applicator in fluid communication with multi-chamber packaging. Applicators according to the instant disclosure have reduced squeeze-strength requirements, and are useful for dispensing fluids, including medicaments, to animals, including livestock animals. The multi-chamber packaging provides separate storage for formulations containing incompatible active ingredients, and is suitable for use with the multi-chamber applicator. The application also discloses methods for using the system to simultaneously deliver multiple active ingredients, at least some of which are not suitable for co-formulation, thus reducing the time, economic burden and animal stress involved with applying multiple, separate formulations to animals. | 05-14-2015 |
20150126523 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS - The present invention relates to novel and inventive isoxazoline of formula (I) and salts thereof: | 05-07-2015 |
20150125487 | Attenuated Pasteurella Multocida Vaccines & Methods of Making & Use Thereof - The present invention provides attenuated | 05-07-2015 |
20150098968 | HAEMOPHILUS PARASUIS VACCINE SEROVAR TYPE FOUR - The present invention is a | 04-09-2015 |
20150073153 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS - Provided are improved processes for the preparation of 1-aryl pyrazole compounds of formula (I) and (IB): | 03-12-2015 |
20150030623 | Recombinant Feline Leukemia Virus Vaccine Containing Optimized Feline Leukemia Virus Envelope Gene - The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions. | 01-29-2015 |
20150011943 | VETERINARY SYRINGE FOR MULTIPLE INJECTIONS - A trigger operated syringe ( | 01-08-2015 |
20150011601 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF - This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds in combination with substituted imidazole compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to an animal in need thereof. | 01-08-2015 |
20140350529 | Sustained Release Capsules - The invention relates to an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral. The capsule can have a dissolvable overcap moulded from plasticised starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule. A piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen. After insertion of the capsule in the animal the overcap (if present) dissolves and separates from the capsule to release the dump dose of medicament. The sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present). | 11-27-2014 |
20140341950 | RECOMBINANT AVIAN PARAMYXOVIRUS VACCINE AND METHOD FOR MAKING AND USING THEREOF - The present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods for modifying the genome of APMV to produce recombinant APMV; modified APMV prepared by such methods; DNA and protein sequences; and methods for infecting cells and host animals with such recombinant APMV. | 11-20-2014 |
20140323559 | LONG-ACTING INJECTABLE MOXIDECTIN FORMULATIONS AND NOVEL MOXIDECTIN CRYSTAL FORMS - This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals. | 10-30-2014 |
20140315794 | ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME - The present invention relates to novel dihydroazole of formula (I) and salts thereof: | 10-23-2014 |
20140314807 | Reverse genetics Schmallenberg virus vaccine compositions, and methods of use thereof - The present invention relates to compositions comprising replication defective Schmallenberg virus vaccines, methods of producing the vaccines, and the administration of such vaccines to animals, including ovines and bovines. The invention further relates to methods for providing long-term protective immunity against Schmallenberg in animals, including ovines and bovines. | 10-23-2014 |
20140303220 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF - This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds in combination with substituted imidazole compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to an animal in need thereof. | 10-09-2014 |
20140294875 | Leishmania Vaccine Using Sand Fly Salivary Immunogen - The present invention provides vectors that contain and express in vivo or in vitro sand fly | 10-02-2014 |
20140271708 | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies G - The present invention relates to compositions comprising replication defective chimeric flavivirus anti-rabies vaccines, methods of producing the vaccines, and the administration of such vaccines to companion animals, including dogs. The invention further relates to methods for providing long-term protective immunity against rabies in companion animals, including dogs and cats. | 09-18-2014 |
20140271526 | ANTIMICROBIAL POLYAMIDE COMPOSITIONS AND MASTITIS TREATMENT - The present invention relates to veterinary compositions and methods of treating and/or preventing mastitis in non-human mammals. More particularly, the present invention relates to the treatment of mastitis in cows. The veterinary composition comprises a water soluble, locally-acting, antimicrobial amine functional polyamide polymer. | 09-18-2014 |
20140234358 | NEWCASTLE DISEASE VIRUS VECTORED AVIAN VACCINES - The present invention encompasses engineered Newcastle Disease Virus (NDV) vaccines or compositions. The vaccine or composition may be a recombinant vaccine. The invention also encompasses recombinant vectors encoding and expressing avian pathogen antigens, more specifically avian influenza proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals, in particular avian, against disease. | 08-21-2014 |
20140213643 | Long-acting nanoencapsulated arthropod repellent formulations and methods of use thereof - The present invention relates to novel nanoencapsulated compositions, methods for making such compositions, and methods of repelling insects and other arthropod pests away from animals, including humans. The present invention has particular, though not sole, application to repelling insects including flies and mosquitoes. The inventive compositions may be used to repel arthropods from animals, humans, plants, soil, or building structures. The formulations also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents. | 07-31-2014 |
20140213624 | METHOD FOR TREATING AND CURING LEISHMANIOSIS USING FEXINIDAZOLE - The present invention encompasses methods of using fexinidazole to treat and eliminate and/or cure | 07-31-2014 |
20140205993 | RECOMBINANT AVIAN INFLUENZA VACCINE AND USES THEREOF - The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines. | 07-24-2014 |
20140205619 | RECOMBINANT AVIAN INFLUENZA VACCINE AND USES THEREOF - The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines. | 07-24-2014 |
20140179746 | AMIDO-PYRIDYL ETHER COMPOUNDS AND COMPOSITIONS AND THEIR USE AGAINST PARASITES - The subject matter disclosed herein is directed to amido-pyridyl ether compounds of formula I: | 06-26-2014 |
20140178860 | High Resolution Melt Genotyping of IBV, CSFV and NDV - The present invention relates to methods of differentiating and characterizing IBV, CSFV and NDV strains, and identifying new strains using high resolution melt technology. The present invention also provides primers and kits for use with such methods. | 06-26-2014 |
20140170190 | Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use - The present invention provides attenuated | 06-19-2014 |
20140147465 | RECOMBINANT GALLID HERPESVIRUS 3 (MDV SEROTYPE 2) VECTORS EXPRESSING ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF - The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors. | 05-29-2014 |
20140147457 | RECOMBINANT HVT VECTORS EXPRESSING ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF - The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors, polyvalent vaccines comprising the recombinant HVT vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors. | 05-29-2014 |
20140142114 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF - The present invention relates to novel anthelmintic compounds of formula (I) below: | 05-22-2014 |
20140120133 | Vaccine Against African Horse Sickness Virus - The present invention provides vectors that contain and express in vivo the genes encoding VP2 and VP5 of African Horse Sickness Virus or an epitope thereof that elicits an immune response in a horse against African horse sickness virus, compositions comprising said vectors, methods of vaccination against African horse sickness virus, and kits for use with such methods and compositions. | 05-01-2014 |
20140080862 | ARYLOAZOL-2-YL CYANOETHYLAMINO COMPOUNDS, METHOD OF MAKING AND METHOD OF USING THEREOF - The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives of formula (I): | 03-20-2014 |
20140072594 | EXPRESSION OF CHIMERIC KSAC PROTEIN AND METHOD OF PRODUCING SOLUBLE PROTEINS BY HIGH PRESSURE - The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes. | 03-13-2014 |
20140065187 | Hyperbaric Device and Methods for Producing Inactivated Vaccines and for Refolding/Solubilizing Recombinant Proteins - The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions. | 03-06-2014 |
20140023681 | Attenuated Swine Influenza Vaccines and Methods of Making and Use Thereof - This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses. Advantageously, the attenuated influenza strains may be administered | 01-23-2014 |
20140023678 | Method of Providing Protective Immunity against Heterologous Leptospira Strains - The present invention provides compositions and methods for eliciting protective immunity in animals against | 01-23-2014 |
20140004144 | Attenuated Streptococcus suis Vaccines and Methods of Making and Use Thereof | 01-02-2014 |
20130337010 | REASSORTANT BTV AND AHSV VACCINES - The present invention encompasses BTV and ASHV vaccines or compositions and methods of producing recombinant reassortant BTV and ASHV vectors and methods of vaccination against BTV and ASHV. | 12-19-2013 |
20130324457 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF - Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): | 12-05-2013 |
20130281710 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS - Provided are improved processes for the preparation of 1-aryl pyrazole compounds of formula (I) and (IB): | 10-24-2013 |
20130281392 | PARASITICIDAL COMPOSITIONS COMPRISING BENZIMIDAZOLE DERIVATIVES, METHODS AND USES THEREOF - The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof. | 10-24-2013 |
20130256170 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND/OR A FORMAMIDINE, METHODS AND USES THEREOF - This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds alone or in combination with formamidine compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to the animal in need thereof. | 10-03-2013 |
20130251747 | RECOMBINANT EQUINE HERPESVIRUS-1 VACCINE CONTAINING MUTATED GLYCOPROTEIN C AND USES THEREOF - The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions. | 09-26-2013 |
20130251737 | Modified Mareks Disease Virus, and Vaccines Made Therefrom - The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent. | 09-26-2013 |
20130225516 | TOPICAL COMPOSITIONS COMPRISING FIPRONIL AND PERMETHRIN AND METHODS OF USE - The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methylpyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methylpyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight:weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methylpyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal. | 08-29-2013 |
20130219530 | Leishmania Challenge Model - The present invention provides a method for effectively and reproducibly infecting canines with | 08-22-2013 |
20130209511 | Recombinant Poxviral Vectors Expressing both Rabies and OX40 Proteins, and Vaccines Made Therefrom - The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus | 08-15-2013 |
20130209507 | Rotavirus Subunit Vaccines and Methods of Making and Use Thereof - The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides. | 08-15-2013 |
20130203692 | PARASITICIDAL ORAL VETERINARY COMPOSITIONS COMPRISING SYSTEMICALLY-ACTING ACTIVE AGENTS, METHODS AND USES THEREOF - This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. | 08-08-2013 |
20130178538 | Long-Acting Injectable Analgesic Formulations for Animals - Long acting injectable analgesic formulations and methods for providing long lasting pain relief in animals are disclosed. | 07-11-2013 |
20130177591 | Lipid Based Adjuvants for DNA Plasmids - The present invention provides for a novel vaccine formulation comprising plasmid DNA and a lipid adjuvant. The invention also provides for prime-boost vaccination methods wherein two sequential administration of the same plasmid-based DNA vaccine provide companion animals with protection against rabies for at least one year. | 07-11-2013 |
20130143956 | LONG-ACTING INJECTABLE MOXIDECTIN FORMULATIONS AND NOVEL MOXIDECTIN CRYSTAL FORMS - This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals. | 06-06-2013 |
20130079394 | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods - This invention relates to novel coumarin derivatives, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents. This invention also relates to novel methods for modeling and/or predicting the repellency of unknown compounds. | 03-28-2013 |
20120009218 | Attenuated Gram Negative Bacteria - Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed. | 01-12-2012 |
20110212129 | Method for Producing the Flu Virus - The invention relates to a method for producing flu virus according to which:
| 09-01-2011 |
20100196381 | P. ARIASI POLYPEPTIDES, P. PERNICIOSUS POLYPEPTIDES AND METHODS OF USE - Substantially purified salivary | 08-05-2010 |
20090163575 | SOLVENT SYSTEMS FOR POUR-ON FORMULATIONS FOR COMBATING PARASITES - This invention relates to pharmaceutical and veterinary formulations providing enhanced solvency and stability for pharmaceutical and veterinary agents for administration to animals, especially ruminants. In addition, the invention relates to pour-on formulations for combating parasites in animals, such as cattle and sheep. In some embodiments, this invention provides glycol-ether-based pour-on formulations comprising a composition comprising a flukicide, such as, for example, clorsulon (4-amino-6-trichloroethenyl-1,3-benzene disulfonamide) and/or a macrolide anthelmintic or antiparasitic agent. In other embodiments, the invention provides pour-on formulations comprising at least one active agent, a glycol ether, and a stability enhancer. This invention also provides for methods for eradicating, controlling, and/or preventing parasite infestation in animals, such as cattle and sheep. | 06-25-2009 |